BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 165 PAIKDPRHLLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMG 244
Cdd:cd18344   1 PAIKDPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 34766462 245 FIYTGKAPHLQSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18344  81 FIYTGKAPHLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 34766462 287 LSVENAAQTLILADLHKREQLKTQALYFIALHASVVSETSEWKSMMETHPHLV 339
Cdd:cd18521   1 LSVKNAAHTLILADLHSTEKLKTQALDFIAVHASEVSETSEWKSMVESHPHLV 53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 165 PAIKDPRHLLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMG 244
Cdd:cd18344   1 PAIKDPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 34766462 245 FIYTGKAPHLQSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18344  81 FIYTGKAPHLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462   178 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAPhlqSH 257
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI---SE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 34766462   258 SMATDVLTAADKYGLEGLKVLCEDALCRNL 287
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462    189 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAPHlqSHSMATDVLTAAD 268
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDL--PEENVEELLELAD 78

                           90
                   ....*....|....*....
gi 34766462    269 KYGLEGLKVLCEDALCRNL 287
Cdd:smart00225  79 YLQIPGLVELCEEFLLKLL 97

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462  200 RAHKAILAARSPVFRAMF-----EHEMeerlgnpTEIHDLDpkVFKEMMGFIYTGKApHLQSHSmATDVLTAADKYGLEG 274
Cdd:PHA03098  24 KVHKIILSSSSEYFKKMFknnfkENEI-------NLNIDYD--SFNEVIKYIYTGKI-NITSNN-VKDILSIANYLIIDF 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 34766462  275 LKVLCEDALCRNLSVENAAQTLILADLHKREQLKTQALYFI 315
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYI 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 165 PAIKDPRHLLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMG 244
Cdd:cd18344   1 PAIKDPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 34766462 245 FIYTGKAPHLQSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18344  81 FIYTGKAPHLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 167 IKDPRHLLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFI 246
Cdd:cd18343   1 LKVPECRLAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 34766462 247 YTGKAPHLQshSMATDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18343  81 YTGKAPNLD--KMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 170 PRHLLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTG 249
Cdd:cd18345   1 PECRLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 34766462 250 KAPHLQshSMATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18345  81 KAPNLD--KMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 174 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAPH 253
Cdd:cd18280   1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 34766462 254 LQSHS----------MATDVLTAADKYGLEGLKVLCEDALC 284
Cdd:cd18280  81 DVEPAgsdsssldttMAQHLLAAADRYALERLRLLCESRLC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 187 FTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAPhlQSHSMATDVLTA 266
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELE--LSEENVEELLAA 78

                ....
gi 34766462 267 ADKY 270
Cdd:cd18186  79 ADKL 82

BACK (BTB and C-terminal Kelch) domain found in TD and POZ domain-containing proteins, Tdpoz1-4; TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", and are not inlcuded in this subfamily.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 34766462 287 LSVENAAQTLILADLHKREQLKTQALYFIALHASVVSETSEWKSMMETHPHLV 339
Cdd:cd18521   1 LSVKNAAHTLILADLHSTEKLKTQALDFIAVHASEVSETSEWKSMVESHPHLV 53

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 34766462 287 LSVENAAQTLILADLHKREQLKTQALYFIALHASVVSETSEWKSMMETHPHLV 339
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLV 53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 176 DDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAP-HL 254
Cdd:cd18297   1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsLD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 34766462 255 QSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18297  81 VAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 34766462 287 LSVENAAQTLILADLHKREQLKTQALYFIALHASVVSETSEWKSMMETHPHLV 339
Cdd:cd18520   1 LSVETAAEVLILADLHSADQLKAQAIDFINTHATDVMETAGWKSMIRTHPHLL 53

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP); SPOP, also termed HIB homolog 1, or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 34766462 287 LSVENAAQTLILADLHKREQLKTQALYFIALHASVVSETSEWKSMMETHPHLVG 340
Cdd:cd18518   1 LSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSGWKSMVVSHPHLVA 54

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 173 LLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAP 252
Cdd:cd18256   6 LILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVE 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 34766462 253 HLQSHsmATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18256  86 VTVSN--VQELLVAADMLQLTEVVEICCEFLKGQLHPSNC 123

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 174 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAPH 253
Cdd:cd18286   4 LGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 34766462 254 LQSHSMaTDVLTAADKYGLEGLKVLCEDALCRNL 287
Cdd:cd18286  84 PDDVNL-GELLSLADMYGLDGLKDVVAYTLRRDY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 169 DPRHL--LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFI 246
Cdd:cd18250   1 DPAHAlhLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 34766462 247 YTGKAPHLQSHsmATDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18250  81 YTGRVTVTQDN--VEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 178 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKApHLQSH 257
Cdd:cd18306   9 LNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRL-EVPAD 87

                        90       100       110
                ....*....|....*....|....*....|....*
gi 34766462 258 SMAtDVLTAADKYGLEGLKVLCEDALCRNLSVENA 292
Cdd:cd18306  88 LVK-SVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 34766462 176 DDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGK 250
Cdd:cd18259  21 DGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGK 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 173 LLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAP 252
Cdd:cd18340  13 LLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIE 92

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 34766462 253 HLQSHsmATDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18340  93 ITEQN--VQDIFAAANMFQIPSIFTVCVSFLQKRLCLSN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 180 ELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKApHLQSHSM 259
Cdd:cd18237  14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARI-SVNSNNV 92

                        90       100       110
                ....*....|....*....|....*....|..
gi 34766462 260 ATdVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18237  93 QS-LLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 169 DPRHL--LTDDLGELWENSLFTDCCLL-VAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGF 245
Cdd:cd18252   1 DSSHPadFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 34766462 246 IYTGK----APHLQShsmatdVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18252  81 VYTSQicitERNVQS------LLEAADLLQFISVKKACEQFLVRHLDIDN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 167 IKDPRH--LLTDDLGELWENSLFTDCCLLVAGHE--------FRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDP 236
Cdd:cd18273   4 LEDAAHarALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 237 KVFKEMMGFIYTGKAphLQSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVENAAQTL 296
Cdd:cd18273  84 ESMALIIDYCYTGRV--TLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 178 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGK-APHLQS 256
Cdd:cd18255   9 LNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSElTLDLDC 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 34766462 257 hsmATDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18255  89 ---IQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34766462 178 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGK 250
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGR 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 173 LLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTgkAP 252
Cdd:cd18341  13 LLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYS--AE 90

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 34766462 253 HLQSHSMATDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18341  91 IDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPAN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34766462 181 LWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLGNPTEIHDLDPKVFKEMMGFIYTGKAphLQSHSMA 260
Cdd:cd18242  15 LRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETV--HVTVENV 92

                        90       100       110
                ....*....|....*....|....*....|.
gi 34766462 261 TDVLTAADKYGLEGLKVLCEDALCRNLSVEN 291
Cdd:cd18242  93 QELLPAACLLQLKGVKQACCEFLESQLDPSN 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 34766462 187 FTDCCLLVAGHEFRAHKAILAARSPVFRAMFEhemEERLGNPTEI--HDLDPKVFKEMMGFIYTGK 250
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK---ETPPDEHPVIilPDVPYSELKALLDFIYTGE 63