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Conserved domains on  [gi|350295459|gb|EGZ76436|]
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hypothetical protein NEUTE2DRAFT_153353 [Neurospora tetrasperma FGSC 2509]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 super family cl48003
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 769-841 1.01e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


The actual alignment was detected with superfamily member pfam08241:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.52  E-value: 1.01e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350295459   769 QLSNSNIRGPPNHRQVAVERLGKLPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYLEF 841
Cdd:pfam08241   30 MLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEvLHHV---------EDPERALREIARVLKPGGILII 94
COG4627 super family cl44094
Predicted SAM-depedendent methyltransferase [General function prediction only];
791-896 8.49e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


The actual alignment was detected with superfamily member COG4627:

Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.86  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459  791 KLPFSDNQFDLISARelHaVLKLFGENGADEWdacLKECMRVLKPGGYLEFSVLDADIMNAGPLGNAKAVEFGFALqtlg 870
Cdd:COG4627    39 PLPFPDNSVDAIYSS--H-VLEHLDYEEAPLA---LKECYRVLKPGGILRIVVPDLEHVARLYLAEYDAALDVAEL---- 108

                          90       100
                  ....*....|....*....|....*.
gi 350295459  871 YDPNPTRSFMARLRRAGFDDIRRAWM 896
Cdd:COG4627   109 RLAGPIDPLGIILGERLAGLAARHSV 134
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 769-841 1.01e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.52  E-value: 1.01e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350295459   769 QLSNSNIRGPPNHRQVAVERLGKLPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYLEF 841
Cdd:pfam08241   30 MLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEvLHHV---------EDPERALREIARVLKPGGILII 94
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
791-896 8.49e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.86  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459  791 KLPFSDNQFDLISARelHaVLKLFGENGADEWdacLKECMRVLKPGGYLEFSVLDADIMNAGPLGNAKAVEFGFALqtlg 870
Cdd:COG4627    39 PLPFPDNSVDAIYSS--H-VLEHLDYEEAPLA---LKECYRVLKPGGILRIVVPDLEHVARLYLAEYDAALDVAEL---- 108

                          90       100
                  ....*....|....*....|....*.
gi 350295459  871 YDPNPTRSFMARLRRAGFDDIRRAWM 896
Cdd:COG4627   109 RLAGPIDPLGIILGERLAGLAARHSV 134
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 791-839 4.03e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 4.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 350295459  791 KLPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYL 839
Cdd:COG2226    80 DLPFPDGSFDLVISSFvLHHL---------PDPERALAEIARVLKPGGRL 120
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 734-843 8.93e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 48.03  E-value: 8.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459   734 RILDLAGqGACDWAWHCALQYPNTKIYTVTTKTLRQLSNSNIR-GPPNHRQVAVERLGKLPFSDNQFDLISARelhavlk 812
Cdd:TIGR01934   42 KVLDVAC-GTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKKsELPLNIEFIQADAEALPFEDNSFDAVTIA------- 113

                           90       100       110
                   ....*....|....*....|....*....|....
gi 350295459   813 lFGENGADEWDACLKECMRVLKPGGY---LEFSV 843
Cdd:TIGR01934  114 -FGLRNVTDIQKALREMYRVLKPGGRlviLEFSK 146
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 791-842 3.87e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 3.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 350295459  791 KLPFSDNQFDLISARelhavlklFG-ENGADEwDACLKECMRVLKPGGY---LEFS 842
Cdd:PRK00216  114 ALPFPDNSFDAVTIA--------FGlRNVPDI-DKALREMYRVLKPGGRlviLEFS 160
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 769-841 1.01e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.52  E-value: 1.01e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350295459   769 QLSNSNIRGPPNHRQVAVERLGKLPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYLEF 841
Cdd:pfam08241   30 MLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEvLHHV---------EDPERALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 791-837 2.64e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 2.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 350295459   791 KLPFSDNQFDLISARE-LHAVlklfgenGADEWDACLKECMRVLKPGG 837
Cdd:pfam13649   56 DLPFPDGSFDLVVSSGvLHHL-------PDPDLEAALREIARVLKPGG 96
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
791-896 8.49e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.86  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459  791 KLPFSDNQFDLISARelHaVLKLFGENGADEWdacLKECMRVLKPGGYLEFSVLDADIMNAGPLGNAKAVEFGFALqtlg 870
Cdd:COG4627    39 PLPFPDNSVDAIYSS--H-VLEHLDYEEAPLA---LKECYRVLKPGGILRIVVPDLEHVARLYLAEYDAALDVAEL---- 108

                          90       100
                  ....*....|....*....|....*.
gi 350295459  871 YDPNPTRSFMARLRRAGFDDIRRAWM 896
Cdd:COG4627   109 RLAGPIDPLGIILGERLAGLAARHSV 134
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 791-839 4.03e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 4.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 350295459  791 KLPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYL 839
Cdd:COG2226    80 DLPFPDGSFDLVISSFvLHHL---------PDPERALAEIARVLKPGGRL 120
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 734-843 8.93e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 48.03  E-value: 8.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459   734 RILDLAGqGACDWAWHCALQYPNTKIYTVTTKTLRQLSNSNIR-GPPNHRQVAVERLGKLPFSDNQFDLISARelhavlk 812
Cdd:TIGR01934   42 KVLDVAC-GTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKKsELPLNIEFIQADAEALPFEDNSFDAVTIA------- 113

                           90       100       110
                   ....*....|....*....|....*....|....
gi 350295459   813 lFGENGADEWDACLKECMRVLKPGGY---LEFSV 843
Cdd:TIGR01934  114 -FGLRNVTDIQKALREMYRVLKPGGRlviLEFSK 146
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 791-842 3.87e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 3.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 350295459  791 KLPFSDNQFDLISARelhavlklFG-ENGADEwDACLKECMRVLKPGGY---LEFS 842
Cdd:PRK00216  114 ALPFPDNSFDAVTIA--------FGlRNVPDI-DKALREMYRVLKPGGRlviLEFS 160
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
781-847 1.11e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 44.22  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 350295459  781 HRQVAVERLGKLPFSDNQFDLISArelHAVLKLFGEngadeWDACLKECMRVLKPGGYLEFSVLDAD 847
Cdd:COG4976    90 YDRLLVADLADLAEPDGRFDLIVA---ADVLTYLGD-----LAAVFAGVARALKPGGLFIFSVEDAD 148
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 792-845 1.54e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 42.70  E-value: 1.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 350295459  792 LPFSDNQFDLISARE-LHAVlklfgengaDEWDACLKECMRVLKPGGYLEFSVLD 845
Cdd:COG2227    81 LPLEDGSFDLVICSEvLEHL---------PDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 736-839 2.82e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.12  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459   736 LDLAGqGACDWAWHCALQYPNTKIYTVTT-----KTLRQLSNSNIRGPPNHRQVAVERLGKLPFsdNQFDLISARE-LHA 809
Cdd:pfam08242    1 LEIGC-GTGTLLRALLEALPGLEYTGLDIspaalEAARERLAALGLLNAVRVELFQLDLGELDP--GSFDVVVASNvLHH 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 350295459   810 VlklfgengaDEWDACLKECMRVLKPGGYL 839
Cdd:pfam08242   78 L---------ADPRAVLRNIRRLLKPGGVL 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 709-839 6.14e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.76  E-value: 6.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459  709 APVAK--RLARQSRFAPGAdgvsrdraRILDLAgqgaCDWAW---HCALQYpNTKIYTVT-----TKTLRQLSNSniRGP 778
Cdd:COG2230    35 AQEAKldLILRKLGLKPGM--------RVLDIG----CGWGGlalYLARRY-GVRVTGVTlspeqLEYARERAAE--AGL 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 350295459  779 PNHRQVAVERLGKLPFsDNQFDLISARE-LHAVlklfgenGADEWDACLKECMRVLKPGGYL 839
Cdd:COG2230   100 ADRVEVRLADYRDLPA-DGQFDAIVSIGmFEHV-------GPENYPAYFAKVARLLKPGGRL 153
arsM PRK11873
arsenite methyltransferase;
786-892 8.08e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.55  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350295459  786 VE-RLG---KLPFSDNQFDLISArelHAVLKLFGENgadewDACLKECMRVLKPGGYLEFSvldaDIMNAGPLGNA--KA 859
Cdd:PRK11873  130 VEfRLGeieALPVADNSVDVIIS---NCVINLSPDK-----ERVFKEAFRVLKPGGRFAIS----DVVLRGELPEEirND 197

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 350295459  860 VEF------GFALQTlgydpnptrSFMARLRRAGFDDIR 892
Cdd:PRK11873  198 AELyagcvaGALQEE---------EYLAMLAEAGFVDIT 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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