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Conserved domains on  [gi|354682633|gb|AER30239|]
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mating pheromone receptor a2 [Sporobolomyces johnsonii]

Protein Classification

7tmD_STE3 domain-containing protein( domain architecture ID 11606510)

7tmD_STE3 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmD_STE3 cd14966
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G ...
6-292 1.09e-93

fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors; This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.


:

Pssm-ID: 320097  Cd Length: 259  Bit Score: 280.16  E-value: 1.09e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633   6 VLMICSGVLVVLNAAPLYWQFAQGNSGPTAMGVWVMVANLNDLINVAVWYSDAVDRAP--IWCDISVKVILGGQVGRLAA 83
Cdd:cd14966    2 AFPIFSFLAFILVIPPLPWHLRARNVGACLLIFWLFLLNLINFVNAIIWPGDDINRAPdkVWCDISTKLIIGASVGIPAA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633  84 VACIARFLADVVSPRATAITYQDRRRRAIFDYSMSFGVPIVVMACHILYQPNRYAIFHGGGCEVTQTMTWPTLVLRMIWG 163
Cdd:cd14966   82 SLCINRRLYRIASTRRVTLTRADKRRRIIIDLLICLGLPILVMALHYIVQGHRYDIFEDVGCYPAIYNSWPALVLVYIWP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633 164 PVFAVTGVLYSAYTVYRLIRHRRDFRRVVSGSHSALTTTRFVRLAALSTSYLLVGLPLSLYSTFVAIVstgrytDYNWdy 243
Cdd:cd14966  162 LIISLIAAVYAVLTLRRFFRRRKQFRDLLSSSNSGLTTSRFLRLMALALVEILITLPLSIYVLVLGSL------ELDR-- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 354682633 244 vhsawklqpvvlydtlqpvdpntWSDVIVGVIFFAAFGFGTDTIVVFKK 292
Cdd:cd14966  234 -----------------------WIPVASAFLFFAFFGFGSEARKMYRR 259
 
Name Accession Description Interval E-value
7tmD_STE3 cd14966
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G ...
6-292 1.09e-93

fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors; This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.


Pssm-ID: 320097  Cd Length: 259  Bit Score: 280.16  E-value: 1.09e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633   6 VLMICSGVLVVLNAAPLYWQFAQGNSGPTAMGVWVMVANLNDLINVAVWYSDAVDRAP--IWCDISVKVILGGQVGRLAA 83
Cdd:cd14966    2 AFPIFSFLAFILVIPPLPWHLRARNVGACLLIFWLFLLNLINFVNAIIWPGDDINRAPdkVWCDISTKLIIGASVGIPAA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633  84 VACIARFLADVVSPRATAITYQDRRRRAIFDYSMSFGVPIVVMACHILYQPNRYAIFHGGGCEVTQTMTWPTLVLRMIWG 163
Cdd:cd14966   82 SLCINRRLYRIASTRRVTLTRADKRRRIIIDLLICLGLPILVMALHYIVQGHRYDIFEDVGCYPAIYNSWPALVLVYIWP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633 164 PVFAVTGVLYSAYTVYRLIRHRRDFRRVVSGSHSALTTTRFVRLAALSTSYLLVGLPLSLYSTFVAIVstgrytDYNWdy 243
Cdd:cd14966  162 LIISLIAAVYAVLTLRRFFRRRKQFRDLLSSSNSGLTTSRFLRLMALALVEILITLPLSIYVLVLGSL------ELDR-- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 354682633 244 vhsawklqpvvlydtlqpvdpntWSDVIVGVIFFAAFGFGTDTIVVFKK 292
Cdd:cd14966  234 -----------------------WIPVASAFLFFAFFGFGSEARKMYRR 259
STE3 pfam02076
Pheromone A receptor;
9-287 6.03e-90

Pheromone A receptor;


Pssm-ID: 460437  Cd Length: 292  Bit Score: 271.74  E-value: 6.03e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633    9 ICSGVLVVLNAAPLYWQFAQGNSGPTAMGVWVMVANLNDLINVAVWYSDAVDRAPI---WCDISVKVILGGQVGRLAAVA 85
Cdd:pfam02076   1 VFSFLAFILLLPPLPWHLRARNIGACSLIFWLLLLNLIYFVNAIIWSGDDIDWAPVgygWCDISTKLIIGASVGIPAALL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633   86 CIARFLADVVSPRATAITYQDRRRRAIFDYSMSFGVPIVVMACHILYQPNRYAIFHGGGCEVTQTMTWPTLVLRMIWGPV 165
Cdd:pfam02076  81 CIARNLYRILSTRAVLLSRKEKRRRIIIDLLICLGIPILQMALHYIVQGHRYDIFEDVGCYPAYYNTWPALVLYIIWPPI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633  166 FAVTGVLYSAYTVYRLIRHRRDFRRVVSGSHSALTTTRFVRLAALSTSYLLVGLPLSLYSTFVAIVSTGRYTDYNWDYVH 245
Cdd:pfam02076 161 ISLIAAVYAGLTLYRFYRRRKQFRDLLSSSNSGLNKSRFLRLLALALLIILITLPLSIYLLVLNITGSPLHPWYSWADVH 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 354682633  246 SAWK-------LQPVVLYDTLQPVDPNTWSDVIVGVIFFAAFGFGTDTI 287
Cdd:pfam02076 241 SDWSrilqipaGEWQYPPSEASALELDRWIPVASAFLFFAFFGFGKEAR 289
 
Name Accession Description Interval E-value
7tmD_STE3 cd14966
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G ...
6-292 1.09e-93

fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors; This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.


Pssm-ID: 320097  Cd Length: 259  Bit Score: 280.16  E-value: 1.09e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633   6 VLMICSGVLVVLNAAPLYWQFAQGNSGPTAMGVWVMVANLNDLINVAVWYSDAVDRAP--IWCDISVKVILGGQVGRLAA 83
Cdd:cd14966    2 AFPIFSFLAFILVIPPLPWHLRARNVGACLLIFWLFLLNLINFVNAIIWPGDDINRAPdkVWCDISTKLIIGASVGIPAA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633  84 VACIARFLADVVSPRATAITYQDRRRRAIFDYSMSFGVPIVVMACHILYQPNRYAIFHGGGCEVTQTMTWPTLVLRMIWG 163
Cdd:cd14966   82 SLCINRRLYRIASTRRVTLTRADKRRRIIIDLLICLGLPILVMALHYIVQGHRYDIFEDVGCYPAIYNSWPALVLVYIWP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633 164 PVFAVTGVLYSAYTVYRLIRHRRDFRRVVSGSHSALTTTRFVRLAALSTSYLLVGLPLSLYSTFVAIVstgrytDYNWdy 243
Cdd:cd14966  162 LIISLIAAVYAVLTLRRFFRRRKQFRDLLSSSNSGLTTSRFLRLMALALVEILITLPLSIYVLVLGSL------ELDR-- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 354682633 244 vhsawklqpvvlydtlqpvdpntWSDVIVGVIFFAAFGFGTDTIVVFKK 292
Cdd:cd14966  234 -----------------------WIPVASAFLFFAFFGFGSEARKMYRR 259
STE3 pfam02076
Pheromone A receptor;
9-287 6.03e-90

Pheromone A receptor;


Pssm-ID: 460437  Cd Length: 292  Bit Score: 271.74  E-value: 6.03e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633    9 ICSGVLVVLNAAPLYWQFAQGNSGPTAMGVWVMVANLNDLINVAVWYSDAVDRAPI---WCDISVKVILGGQVGRLAAVA 85
Cdd:pfam02076   1 VFSFLAFILLLPPLPWHLRARNIGACSLIFWLLLLNLIYFVNAIIWSGDDIDWAPVgygWCDISTKLIIGASVGIPAALL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633   86 CIARFLADVVSPRATAITYQDRRRRAIFDYSMSFGVPIVVMACHILYQPNRYAIFHGGGCEVTQTMTWPTLVLRMIWGPV 165
Cdd:pfam02076  81 CIARNLYRILSTRAVLLSRKEKRRRIIIDLLICLGIPILQMALHYIVQGHRYDIFEDVGCYPAYYNTWPALVLYIIWPPI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354682633  166 FAVTGVLYSAYTVYRLIRHRRDFRRVVSGSHSALTTTRFVRLAALSTSYLLVGLPLSLYSTFVAIVSTGRYTDYNWDYVH 245
Cdd:pfam02076 161 ISLIAAVYAGLTLYRFYRRRKQFRDLLSSSNSGLNKSRFLRLLALALLIILITLPLSIYLLVLNITGSPLHPWYSWADVH 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 354682633  246 SAWK-------LQPVVLYDTLQPVDPNTWSDVIVGVIFFAAFGFGTDTI 287
Cdd:pfam02076 241 SDWSrilqipaGEWQYPPSEASALELDRWIPVASAFLFFAFFGFGKEAR 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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