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Conserved domains on  [gi|356991192|ref|NP_001239323|]
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mitochondrial thiamine pyrophosphate carrier isoform 2 [Mus musculus]

Protein Classification

solute carrier family 25 protein( domain architecture ID 13621020)

solute carrier family 25 (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020
PubMed:  23266187
TCDB:  2.A.29

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
16-108 4.22e-23

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192   16 LEVAVAGSVSGFVTRALISPLDVIKIRFQLQierlcPSDPNAKYHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYGAV 95
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 356991192   96 QFLAFEELTELLY 108
Cdd:pfam00153  81 YFGTYETLKRLLL 93
Mito_carr super family cl37969
Mitochondrial carrier protein;
118-166 1.45e-07

Mitochondrial carrier protein;


The actual alignment was detected with superfamily member pfam00153:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 48.04  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 356991192  118 FSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKGTLKT----CFVAVVRE 166
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRgildCFKKIYKE 57
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
16-108 4.22e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192   16 LEVAVAGSVSGFVTRALISPLDVIKIRFQLQierlcPSDPNAKYHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYGAV 95
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 356991192   96 QFLAFEELTELLY 108
Cdd:pfam00153  81 YFGTYETLKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
20-148 4.51e-09

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 55.16  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192  20 VAGSVSGFVTRALISPLDVIKIRFQLQierlcPSDPNAK------YHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYG 93
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTQ-----DSIPEIKsgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 356991192  94 AVQFlAFEELTELL---YQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAA 148
Cdd:PTZ00169  87 AFNF-AFKDYFKNMfpkYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLAS 143
Mito_carr pfam00153
Mitochondrial carrier protein;
118-166 1.45e-07

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 48.04  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 356991192  118 FSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKGTLKT----CFVAVVRE 166
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRgildCFKKIYKE 57
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
16-108 4.22e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 4.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192   16 LEVAVAGSVSGFVTRALISPLDVIKIRFQLQierlcPSDPNAKYHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYGAV 95
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 356991192   96 QFLAFEELTELLY 108
Cdd:pfam00153  81 YFGTYETLKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
20-148 4.51e-09

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 55.16  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192  20 VAGSVSGFVTRALISPLDVIKIRFQLQierlcPSDPNAK------YHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYG 93
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTQ-----DSIPEIKsgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 356991192  94 AVQFlAFEELTELL---YQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAA 148
Cdd:PTZ00169  87 AFNF-AFKDYFKNMfpkYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLAS 143
Mito_carr pfam00153
Mitochondrial carrier protein;
118-166 1.45e-07

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 48.04  E-value: 1.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 356991192  118 FSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKGTLKT----CFVAVVRE 166
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRgildCFKKIYKE 57
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
4-107 1.55e-03

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 38.98  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192   4 YD-AKADVRSNSK-----LEVAVAGSVSgfVTRALIS-PLDVIKIRFQLQIERLCPSDpnAKYHGIFQAAKQILQEEGPR 76
Cdd:PTZ00169 194 YDsAKALLFGNDKntnilYKWAVAQTVT--ILAGLISyPFDTVRRRMMMMSGRKAKSE--IQYTGTLDCWKKILKNEGLG 269
                         90       100       110
                 ....*....|....*....|....*....|.
gi 356991192  77 AFWKGHVpAQILSIGYGAVQFLAFEELTELL 107
Cdd:PTZ00169 270 GFFKGAW-ANVLRGAGGALVLVFYDELQKLL 299
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
20-167 1.72e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 38.37  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192  20 VAGSVSGFVTRALISPLDVIKIRFQLQiERLCPSDPNAKYHGIFQAAkqilqeegprafwKGHVPAQILsigygavqFLA 99
Cdd:PTZ00168   8 VTGALSGVIVDAVLYPIDSIKTNIQAK-KSFSFSDIKKLYSGILPTL-------------VGTVPASAF--------FYC 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356991192 100 FEELTELLYQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGE----------------PKGTLKTCFVAV 163
Cdd:PTZ00168  66 FYELSKKLLTEYRENISKTNLYLISTSIAEITACIVRLPFEIVKQNMQVSGNisvlktiyeitqreglPSFLGKSYFVMI 145

                 ....
gi 356991192 164 VREL 167
Cdd:PTZ00168 146 VREI 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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