|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
295-807 |
1.65e-145 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 444.67 E-value: 1.65e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 295 REQPSLLNqsLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREV 374
Cdd:COG0553 232 ESLPAGLK--ATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQREL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 375 NLWCPSLNVLCYYGSQEERKQIrfnihNKYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 454
Cdd:COG0553 310 AKFAPGLRVLVLDGTRERAKGA-----NPFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAV 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 455 MTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKPADEqsiyekERIAHAKQIIKPFILRRVK 534
Cdd:COG0553 382 RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSL-KAFRERFARPIEKGDE------EALERLRRLLRPFLLRRTK 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 535 EEVLKLLPPKKDRIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNV---MMQLRKMANHPllhrqyytpeklkems 611
Cdd:COG0553 455 EDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGLIlaaLTRLRQICSHP---------------- 518
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 612 QLMLKEPThceanpdlifedmevmtdfelhvlckqyqhinsyqldmDLILDSGKFRALGCILSELKQKGDRVVLFSQFTM 691
Cdd:COG0553 519 ALLLEEGA--------------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTD 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 692 MLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAED 771
Cdd:COG0553 561 TLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAID 640
|
490 500 510
....*....|....*....|....*....|....*.
gi 358438428 772 RCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKL 807
Cdd:COG0553 641 RAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
307-489 |
3.48e-125 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 373.64 E-value: 3.48e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCY 386
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLT 466
Cdd:cd17998 81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|...
gi 358438428 467 GTPVQNNLLELMSLLNFVMPHMF 489
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
286-808 |
3.09e-114 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 372.21 E-value: 3.09e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 286 LTGNGGGWNREQPSLLNQSLslKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQ-EGNKGPHLIVVPA 364
Cdd:PLN03142 151 LGGSGGTRLLVQPSCIKGKM--RDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPK 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 365 STIDNWLREVNLWCPSLNVLCYYGSQEERKQIRFNIHNKyEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLK 444
Cdd:PLN03142 229 STLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVA-GKFDVCVTSFEMAIK---EKTALKRFSWRYIIIDEAHRIK 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 445 NMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKpADEQsiyekERIAHAKQI 524
Cdd:PLN03142 305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGE-NDQQ-----EVVQQLHKV 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 525 IKPFILRRVKEEVLKLLPPKKDRIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQyytp 604
Cdd:PLN03142 378 LRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFQG---- 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 605 eklkemsqlmlkepthCEANPdlifedmevmtdfelhvlckqyqhinSYQLDMDLILDSGKFRALGCILSELKQKGDRVV 684
Cdd:PLN03142 454 ----------------AEPGP--------------------------PYTTGEHLVENSGKMVLLDKLLPKLKERDSRVL 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 685 LFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTD-MDIFVFLLSTKAGGLGINLTSANVVILHDIDCNP 763
Cdd:PLN03142 492 IFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAGGLGINLATADIVILYDSDWNP 571
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 358438428 764 YNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE 808
Cdd:PLN03142 572 QVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
307-489 |
1.67e-81 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 259.42 E-value: 1.67e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNK-GPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKErGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRfnIHNKYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd17919 81 YHGSQRERAQIR--AKEKLDKFDVVLTTYETL---RRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLL 155
|
170 180
....*....|....*....|....
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMF 489
Cdd:cd17919 156 TGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
307-532 |
5.94e-79 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 254.20 E-value: 5.94e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-FQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIHNKYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNS-FHVCITSYQLVVQ---DHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSS-KTKPADEQSIYEKERIAHAKQIIKPFILRR 532
Cdd:cd18003 157 TGTPLQNSLMELWSLMHFLMPHIFQSHQ-EFKEWFSNpLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
310-595 |
1.80e-77 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 252.60 E-value: 1.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 310 YQKVGLNWL-ALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNK--GPHLIVVPASTIDNWLREVNLWC--PSLNVL 384
Cdd:pfam00176 1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 385 CYYGSQEERKQIrFNIHNKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLL 464
Cdd:pfam00176 81 VLHGNKRPQERW-KNDPNFLADFDVVITTYETLRK---HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 465 LTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSktkpaDEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPK 544
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSL-STFRNWFDR-----PIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPK 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 358438428 545 KDRIELCAMSEKQEQLY-----SGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHP 595
Cdd:pfam00176 231 VEYILFCRLSKLQRKLYqtfllKKDLNAIKTGEGGREIKASLLNILMRLRKICNHP 286
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
307-534 |
3.69e-75 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 244.60 E-value: 3.69e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCY 386
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRFNIHNK---YEDYNVIVTTYNCAIsssDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRL 463
Cdd:cd18009 84 HGTKEERERLRKKIMKRegtLQDFPVVVTSYEIAM---RDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358438428 464 LLTGTPVQNNLLELMSLLNFVMPHMFSS-STSEIRRMFSSKTKPADEQSIYEKERIAHA----KQIIKPFILRRVK 534
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDlSSFESWFDFSSLSDNAADISNLSEEREQNIvhmlHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
307-534 |
2.17e-72 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 236.45 E-value: 2.17e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNK-GPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNInGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIHnKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd17997 84 LIGDKEERADIIRDVL-LPGKFDVCITSYEMVIK---EKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKPADEQsiyekERIAHAKQIIKPFILRRVK 534
Cdd:cd17997 160 TGTPLQNNLHELWALLNFLLPDVFTSS-EDFDEWFNVNNCDDDNQ-----EVVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
307-534 |
2.60e-70 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 230.92 E-value: 2.60e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCY 386
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRfnihnKYEDYNVIVTTYNcaisssddrsLFRRL-------KLNYAIFDEGHMLKNMGSIRYQHLMTINA 459
Cdd:cd18012 85 HGTKRKREKLR-----ALEDYDLVITSYG----------LLRRDiellkevKFHYLVLDEAQNIKNPQTKTAKAVKALKA 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 358438428 460 RNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSsktKPADEQSiyEKERIAHAKQIIKPFILRRVK 534
Cdd:cd18012 150 DHRLALTGTPIENHLGELWSIFDFLNPGLLGSY-KRFKKRFA---KPIEKDG--DEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
307-534 |
1.55e-65 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 218.39 E-value: 1.55e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQ-EGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKIV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIhnKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT-INARNRLL 464
Cdd:cd17996 84 YKGTPDVRKKLQSQI--RAGKFNVLLTTYEYIIK---DKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358438428 465 LTGTPVQNNLLELMSLLNFVMPHMFSSSTSeIRRMFS---SKTKPADEQSIYEKER---IAHAKQIIKPFILRRVK 534
Cdd:cd17996 159 LTGTPLQNNLPELWALLNFLLPKIFKSCKT-FEQWFNtpfANTGEQVKIELNEEETlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
307-532 |
2.46e-63 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 211.83 E-value: 2.46e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNK-GPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQyGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIR----FNIHNKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARN 461
Cdd:cd17993 82 YLGDIKSRDTIReyefYFSQTKKLKFNVLLTTYEIILK---DKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 358438428 462 RLLLTGTPVQNNLLELMSLLNFVMPHMFssstsEIRRMFSsktkpaDEQSIYEKERIAHAKQIIKPFILRR 532
Cdd:cd17993 159 RLLITGTPLQNSLKELWALLHFLMPGKF-----DIWEEFE------EEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
307-532 |
2.49e-63 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 212.36 E-value: 2.49e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNK-GPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIHNK---YED--YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINAR 460
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKnlyTRDapFHVVITSYQLVVQ---DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 358438428 461 NRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKP-ADEQSIYEKERIAHAKQIIKPFILRR 532
Cdd:cd18002 158 NRLLLTGTPIQNSMAELWALLHFIMPTLFDSH-DEFNEWFSKDIEShAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
307-532 |
9.83e-60 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 202.48 E-value: 9.83e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREVNLWCPsLNVLC 385
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGiRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRfnihnKYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIR 450
Cdd:cd17995 80 YHGSGESRQIIQ-----QYEMYfkdaqgrkkkgvykfDVLITTYEMVIA---DAEELRKIPWRVVVVDEAHRLKNRNSKL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 451 YQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSsktkpadeqSIYEKERIAHAKQIIKPFIL 530
Cdd:cd17995 152 LQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSE-EFLEEFG---------DLKTAEQVEKLQALLKPYML 221
|
..
gi 358438428 531 RR 532
Cdd:cd17995 222 RR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
663-788 |
1.19e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 190.38 E-value: 1.19e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 663 SGKFRALGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAG 742
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 358438428 743 GLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLI 788
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
307-532 |
4.60e-54 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 186.49 E-value: 4.60e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-FQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLaGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIHNkYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd18006 81 YMGDKEKRLDLQQDIKS-TNRFHVLLTTYEICLK---DASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMFSSSTSEirRMFSSKTKPADEQSIYEKeriahAKQIIKPFILRR 532
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFPKDKLD--DFIKAYSETDDESETVEE-----LHLLLQPFLLRR 216
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
307-532 |
7.73e-54 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 186.42 E-value: 7.73e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCY 386
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YG-SQEERKQIRFNIHNKyedYNVIVTTYNCAISSSDDRSLFRR--LKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRL 463
Cdd:cd18001 81 HGtSKKERERNLERIQRG---GGVLLTTYGMVLSNTEQLSADDHdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRI 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 358438428 464 LLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERI------AHAKQIIKPFILRR 532
Cdd:cd18001 158 ILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFENPITRGRDKDATQGEKAlgsevaENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
295-532 |
4.00e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 179.05 E-value: 4.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 295 REQPSLL-NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLF-QEGNKGPHLIVVPASTIDNWLR 372
Cdd:cd18054 8 KKQPSYIgGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 373 EVNLWCPSLNVLCYYGSQEERKQIR----FNIHNKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGS 448
Cdd:cd18054 88 EFEIWAPEINVVVYIGDLMSRNTIReyewIHSQTKRLKFNALITTYEILLK---DKTVLGSINWAFLGVDEAHRLKNDDS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 449 IRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKPADEQSIYekeriahakQIIKPF 528
Cdd:cd18054 165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEF--WEDFEEDHGKGRENGYQSLH---------KVLEPF 233
|
....
gi 358438428 529 ILRR 532
Cdd:cd18054 234 LLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
307-545 |
4.41e-51 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 179.09 E-value: 4.41e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNIHNKYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd18064 96 LIGDKDQRAAFVRDVLLPGE-WDVCVTSYEMLIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKPADEQSIyekERIahaKQIIKPFILRRVKEEVLKLLPPKK 545
Cdd:cd18064 172 TGTPLQNNLHELWALLNFLLPDVFNSA-EDFDSWFDTNNCLGDQKLV---ERL---HMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
296-534 |
6.87e-48 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 169.81 E-value: 6.87e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 296 EQPSLLNQSlSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREV 374
Cdd:cd18065 6 ESPSYVKGG-TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNiPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 375 NLWCPSLNVLCYYGSQEERKQIRFNIHNKYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 454
Cdd:cd18065 85 KRWVPSLRAVCLIGDKDARAAFIRDVMMPGE-WDVCVTSYEMVIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 455 MTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKPADEQSIyekERIaHAkqIIKPFILRRVK 534
Cdd:cd18065 161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWFDTKNCLGDQKLV---ERL-HA--VLKPFLLRRIK 233
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
307-532 |
3.90e-47 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 167.53 E-value: 3.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA---YLFQEGNKG---PHLIVVPASTIDNWLREVNLWCP- 379
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 380 -SLNVLCYYGSQEERKQIRFNIHNKyedyNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTIN 458
Cdd:cd17999 81 aFLKPLAYVGPPQERRRLREQGEKH----NVIVASYDVLRNDIE---VLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 459 ARNRLLLTGTPVQNNLLELMSLLNFVMPHmFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQI------IKPFILRR 532
Cdd:cd17999 154 ANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALealhkqVLPFLLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
307-486 |
4.44e-46 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 163.26 E-value: 4.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-FQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVL- 384
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 385 ----CYYGSQEERKQIRFN----IHNKYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMG---SIRYQH 453
Cdd:cd18000 81 lhssGSGTGSEEKLGSIERksqlIRKVVGDGGILITTYEGFRKHKD---LLLNHNWQYVILDEGHKIRNPDaeiTLACKQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 358438428 454 LMTInarNRLLLTGTPVQNNLLELMSLLNFVMP 486
Cdd:cd18000 158 LRTP---HRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
295-532 |
5.07e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 159.06 E-value: 5.07e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 295 REQPSLL--NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWL 371
Cdd:cd18053 7 KKQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQlYGPFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 372 REVNLWCPSLNVLCYYGSQEERKQIR----FNIHNKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMG 447
Cdd:cd18053 87 REIQTWAPQMNAVVYLGDINSRNMIRthewMHPQTKRLKFNILLTTYEILLK---DKSFLGGLNWAFIGVDEAHRLKNDD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 448 SIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKPADEQSIYEKeriahakqiIKP 527
Cdd:cd18053 164 SLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSS--WEDFEEEHGKGREYGYASLHKE---------LEP 232
|
....*
gi 358438428 528 FILRR 532
Cdd:cd18053 233 FLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
307-532 |
6.79e-43 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 154.52 E-value: 6.79e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHsKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSqeerkqirfnihnkyedyNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLL 465
Cdd:cd17994 81 YVGD------------------HVLLTSYELI---SIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLL 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358438428 466 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSsktkpADEQSIYEKERIAHAKQIIKPFILRR 532
Cdd:cd17994 140 TGTPLQNNLEELFHLLNFLTPERFNNLQG-----FL-----EEFADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
296-534 |
1.69e-42 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 155.20 E-value: 1.69e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 296 EQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREV 374
Cdd:cd18062 13 EKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRiNGPFLIIVPLSTLSNWVYEF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 375 NLWCPSLNVLCYYGSQEERKQirFNIHNKYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 454
Cdd:cd18062 93 DKWAPSVVKVSYKGSPAARRA--FVPQLRSGKFNVLLTTYEYIIK---DKQILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 455 MT-INARNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMFSSKTKPADEQSIYEKER----IAHAKQIIKPFI 529
Cdd:cd18062 168 NThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTGEKVDLNEEEtiliIRRLHKVLRPFL 246
|
....*
gi 358438428 530 LRRVK 534
Cdd:cd18062 247 LRRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
296-534 |
1.89e-42 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 155.22 E-value: 1.89e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 296 EQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREV 374
Cdd:cd18063 13 EKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRlNGPYLIIVPLSTLSNWTYEF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 375 NLWCPSLNVLCYYGSQEERKQIRFNIHNKyeDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 454
Cdd:cd18063 93 DKWAPSVVKISYKGTPAMRRSLVPQLRSG--KFNVLLTTYEYIIK---DKHILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 455 MT-INARNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMFSSKTKPADEQSIYEKER----IAHAKQIIKPFI 529
Cdd:cd18063 168 NThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTGERVDLNEEEtiliIRRLHKVLRPFL 246
|
....*
gi 358438428 530 LRRVK 534
Cdd:cd18063 247 LRRLK 251
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
307-532 |
4.06e-42 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 153.98 E-value: 4.06e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLaLVHkhGlnGILADEMGLGKTIQAIA----------FLAYLFQEGNKGPH--------LIVVPASTID 368
Cdd:cd18008 1 LLPYQKQGLAWM-LPR--G--GILADEMGLGKTIQALAlilatrpqdpKIPEELEENSSDPKklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 369 NWLREVN--LWCPSLNVLCYYGSQeerkqirfNIHNKYE--DYNVIVTTYN-CAISSSDDRSLFRRLKLNYA-------- 435
Cdd:cd18008 76 QWKDEIEkhTKPGSLKVYVYHGSK--------RIKSIEElsDYDIVITTYGtLASEFPKNKKGGGRDSKEKEasplhrir 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 436 ----IFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNF--VMP-HMFSSSTSEIRRMFSSktkpad 508
Cdd:cd18008 148 wyrvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFlrVEPfGDYPWFNSDISKPFSK------ 221
|
250 260
....*....|....*....|....
gi 358438428 509 eqsiYEKERIAHAKQIIKPFILRR 532
Cdd:cd18008 222 ----NDRKALERLQALLKPILLRR 241
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
307-532 |
5.68e-40 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 147.82 E-value: 5.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWL--ALVHKHGLNG---ILADEMGLGKTIQAIAFLAYLFQEG-NKGPH----LIVVPASTIDNWLREVNL 376
Cdd:cd18004 1 LRPHQREGVQFLydCLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGpYGKPTakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 377 WCPS--LNVLCYYGSQEERKQIRFNIhNKYEDYNVIVTTYNCAISSSddRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 454
Cdd:cd18004 81 WLGLrrIKVVTADGNAKDVKASLDFF-SSASTYPVLIISYETLRRHA--EKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 455 MTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMF------SSKTKPADEQSIYEKERIAHAKQIIKPF 528
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSL-ASFRKVFeepilrSRDPDASEEDKELGAERSQELSELTSRF 236
|
....
gi 358438428 529 ILRR 532
Cdd:cd18004 237 ILRR 240
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
307-532 |
8.86e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 146.73 E-value: 8.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCpSLNVLCY 386
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQI-RFNIHNKYED---------YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 456
Cdd:cd18058 80 HGSQISRQMIqQYEMYYRDEQgnplsgifkFQVVITTFEMILA---DCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358438428 457 INARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTkpadeqsiyeKERIAHAKQIIKPFILRR 532
Cdd:cd18058 157 MALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
307-532 |
2.91e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 139.40 E-value: 2.91e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCpSLNVLCY 386
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRFN-----------IHNKYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 455
Cdd:cd18059 80 HGSQASRRTIQLYemyfkdpqgrvIKGSYK-FHAIITTFEMILT---DCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358438428 456 TINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTkpadeqsiyeKERIAHAKQIIKPFILRR 532
Cdd:cd18059 156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
307-532 |
3.12e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 139.42 E-value: 3.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCpSLNVLCY 386
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRfnihnKYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRY 451
Cdd:cd18060 80 HGSLASRQMIQ-----QYEMYckdsrgrlipgaykfDALITTFEMILS---DCPELREIEWRCVIIDEAHRLKNRNCKLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 452 QHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTkpadeqsiyeKERIAHAKQIIKPFILR 531
Cdd:cd18060 152 DSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLR 221
|
.
gi 358438428 532 R 532
Cdd:cd18060 222 R 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
307-532 |
4.17e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 139.43 E-value: 4.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEG-NKGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGhSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNiHNKYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 446
Cdd:cd18057 81 YTGDKESRSVIREN-EFSFEDnairsgkkvfrmkkeaqikFHVLLTSYELI---TIDQAILGSIEWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 447 GSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktkpADeqsIYEKERIAHAKQIIK 526
Cdd:cd18057 157 QSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226
|
....*.
gi 358438428 527 PFILRR 532
Cdd:cd18057 227 PHMLRR 232
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
307-502 |
3.56e-36 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 136.65 E-value: 3.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLN--WLALVHKHGLNG-----ILADEMGLGKTIQAIAFLAYLFQEGNKGPH-LIVVPASTIDNWLREVNLWC 378
Cdd:cd18007 1 LKPHQVEGVRflWSNLVGTDVGSDegggcILAHTMGLGKTLQVITFLHTYLAAAPRRSRpLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 379 PS----LNVLCYYGSQEERKQIRFNIHNKYED-------YNVIVTTYNCAISSSDDRSLFRRLKL----NYAIFDEGHML 443
Cdd:cd18007 81 PPdlrpLLVLVSLSASKRADARLRKINKWHKEggvlligYELFRNLASNATTDPRLKQEFIAALLdpgpDLLVLDEGHRL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 358438428 444 KNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSS 502
Cdd:cd18007 161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLK-EFKKKFVK 218
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
307-532 |
7.30e-36 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 135.97 E-value: 7.30e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQ---------------------EGNKGPHLIVVPAS 365
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrennrprfkkkppaSSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 366 TIDNWLREVNLWcPSLNVLCYYGSQEERKQIRFNIHNKYEdynVIVTTYncaisssddrSLFRR-------LKLNYAIFD 438
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDELEGRLKAGRLE---VVVTTY----------DTLRRcidslnsINWSAVIAD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 439 EGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFS-------SKTKPADEQS 511
Cdd:cd18005 147 EAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSepikrgqRHTATARELR 225
|
250 260
....*....|....*....|.
gi 358438428 512 IYEKeRIAHAKQIIKPFILRR 532
Cdd:cd18005 226 LGRK-RKQELAVKLSKFFLRR 245
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
307-532 |
9.51e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 135.52 E-value: 9.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHtKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNiHNKYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 446
Cdd:cd18055 81 YTGDKDSRAIIREN-EFSFDDnavkggkkafkmkreaqvkFHVLLTSYELV---TIDQAALGSIRWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 447 GSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktkpADeqsIYEKERIAHAKQIIK 526
Cdd:cd18055 157 QSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226
|
....*.
gi 358438428 527 PFILRR 532
Cdd:cd18055 227 PHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
307-532 |
1.20e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 135.19 E-value: 1.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEG-NKGPHLIVVPASTIDNWLREVNLWCPSLNVLC 385
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGhSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGSQEERKQIRFNiHNKYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 446
Cdd:cd18056 81 YVGDKDSRAIIREN-EFSFEDnairggkkasrmkkeasvkFHVLLTSYELI---TIDMAILGSIDWACLIVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 447 GSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktkpADeqsIYEKERIAHAKQIIK 526
Cdd:cd18056 157 QSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEF-------AD---IAKEDQIKKLHDMLG 226
|
....*.
gi 358438428 527 PFILRR 532
Cdd:cd18056 227 PHMLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
307-532 |
3.01e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 127.81 E-value: 3.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCpSLNVLCY 386
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 YGSQEERKQIRfnihnKYEDY---------------NVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRY 451
Cdd:cd18061 80 HGSLISRQMIQ-----QYEMYfrdsqgriirgayrfQAIITTFEMILGGCPE---LNAIDWRCVIIDEAHRLKNKNCKLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 452 QHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTkpadeqsiyeKERIAHAKQIIKPFILR 531
Cdd:cd18061 152 EGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLR 221
|
.
gi 358438428 532 R 532
Cdd:cd18061 222 R 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
307-486 |
6.12e-32 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 123.37 E-value: 6.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLalvHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVP-ASTIDNWLREVNLWCPSLN--V 383
Cdd:smart00487 9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPSLGlkV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 384 LCYYGSQEERKQIRFNIHNKyedYNVIVTTYNCAISSSDDRSLFRRlKLNYAIFDEGHMLKNMGsiRYQHLMTI-----N 458
Cdd:smart00487 86 VGLYGGDSKREQLRKLESGK---TDILVTTPGRLLDLLENDKLSLS-NVDLVILDEAHRLLDGG--FGDQLEKLlkllpK 159
|
170 180 190
....*....|....*....|....*....|.
gi 358438428 459 ARNRLLLTGTP---VQNNLLELMSLLNFVMP 486
Cdd:smart00487 160 NVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
307-498 |
3.66e-30 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 118.46 E-value: 3.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWlALvhKHGLNGILADEMGLGKTIQAIAFLAYLFQEgnkGPHLIVVPASTIDNWLREVNLWCPSLNVlcy 386
Cdd:cd18010 1 LLPFQREGVCF-AL--RRGGRVLIADEMGLGKTVQAIAIAAYYREE---WPLLIVCPSSLRLTWADEIERWLPSLPP--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 387 ygsqeerkqirfnihnkyEDYNVIVTTyNCAISSSDDR------SLFRRL-------KLNYAIFDEGHMLKNMGSIRYQH 453
Cdd:cd18010 72 ------------------DDIQVIVKS-KDGLRDGDAKvvivsyDLLRRLekqllarKFKVVICDESHYLKNSKAKRTKA 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 358438428 454 LMTI--NARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRR 498
Cdd:cd18010 133 ALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
307-532 |
5.72e-29 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 115.71 E-value: 5.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWL-----ALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPH------LIVVPASTIDNWLREVN 375
Cdd:cd18066 1 LRPHQREGIEFLyecvmGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 376 LWCPSLNVLCYYGSQEerKQIRFNIHNKYedYNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 455
Cdd:cd18066 81 KWLGSERIKVFTVDQD--HKVEEFIASPL--YSVLIISYEMLLRSLDQ---ISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 456 TINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMFSSKTKPADEQSIYEKE------RIAHAKQIIKPFI 529
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGIL-GSLSTYRKVYEEPIVRSREPTATPEEkklgeaRAAELTRLTGLFI 232
|
...
gi 358438428 530 LRR 532
Cdd:cd18066 233 LRR 235
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
307-532 |
1.36e-26 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 109.10 E-value: 1.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWL----ALVHKHGLNG-ILADEMGLGKTIQAIAFLAYLFQEGNKGPHLI-----VVPASTIDNWLREVNL 376
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 377 WC-PSLNVLCYYGSQEE---RKQIRF-NIHNKYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRY 451
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKeidRKLVQWaSQQGRRVSTPVLIISYETFRLHVE---VLQKGEVGLVICDEGHRLKNSDNQTY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 452 QHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSS---KTKPAD--EQSIYE-KERIAHAKQII 525
Cdd:cd18067 158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTA-AEFKKNFELpilKGRDADasEKERQLgEEKLQELISIV 236
|
....*..
gi 358438428 526 KPFILRR 532
Cdd:cd18067 237 NRCIIRR 243
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
664-777 |
1.84e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 101.52 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 664 GKFRALGCILSelKQKGDRVVLFSQFTMMLDIlEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDmDIFVfLLSTKAGG 743
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 358438428 744 LGINLTSANVVILHDIDCNPYNDKQAEDRCHRVG 777
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
325-500 |
2.65e-25 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 104.90 E-value: 2.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 325 GLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCYY----------GSQEERK 394
Cdd:cd18069 28 GFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPPPEALPNVrprpfkvfilNDEHKTT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 395 QIRFNIHNKY-EDYNVIVTTYncaisssddrSLFR-RLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQN 472
Cdd:cd18069 108 AARAKVIEDWvKDGGVLLMGY----------EMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQN 177
|
170 180
....*....|....*....|....*...
gi 358438428 473 NLLELMSLLNFVMPHMFSSSTsEIRRMF 500
Cdd:cd18069 178 NLIEYWCMVDFVRPDFLGTRQ-EFSNMF 204
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
307-531 |
5.27e-24 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 102.04 E-value: 5.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLaLVHKhglnGILADEMGLGKTIQAIAFL------------AYLFQEGNK--------------GPHLI 360
Cdd:cd18070 1 LLPYQRRAVNWM-LVPG----GILADEMGLGKTVEVLALIllhprpdndldaADDDSDEMVccpdclvaetpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 361 VVPASTIDNWLREVNLWCP-SLNVLCYYGsQEERKQIRFNIHNKYEDYNVIVTTYN-------CAISSSDDRSLfRRLKL 432
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQG-VKKDGALASPAPEILAEYDIVVTTYDvlrtelhYAEANRSNRRR-RRQKR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 433 NYAI-------------FDEGHMLKnmGSIRYQHLMT--INARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIR 497
Cdd:cd18070 154 YEAPpsplvlvewwrvcLDEAQMVE--SSTSKAAEMArrLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWAR 231
|
250 260 270
....*....|....*....|....*....|....
gi 358438428 498 RMFssktkpadeQSIYEKERIAHAKQIIKPFILR 531
Cdd:cd18070 232 VLI---------RPQGRNKAREPLAALLKELLWR 256
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
325-484 |
1.75e-22 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 97.15 E-value: 1.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 325 GLNGILADEMGLGKTIQAIAFLayLFQegnkgPHLIVVPASTIDNWLREV--NLWCPSLNVLCYYGSQEERKQirfnihN 402
Cdd:cd18071 48 VRGGILADDMGLGKTLTTISLI--LAN-----FTLIVCPLSVLSNWETQFeeHVKPGQLKVYTYHGGERNRDP------K 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 403 KYEDYNVIVTTYNCAIS--SSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSL 480
Cdd:cd18071 115 LLSKYDIVLTTYNTLASdfGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194
|
....
gi 358438428 481 LNFV 484
Cdd:cd18071 195 LSFL 198
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
307-482 |
4.31e-22 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 95.05 E-value: 4.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNwLALVHKHgLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREvnLW-CPSLNVLC 385
Cdd:cd18011 1 PLPHQIDAVL-RALRKPP-VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDE--LQdKFGLPFLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 386 YYGsqEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTI------NA 459
Cdd:cd18011 77 LDR--ETAAQLRRLIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrllakRA 154
|
170 180
....*....|....*....|....*.
gi 358438428 460 RNRLLLTGTPVQNN---LLELMSLLN 482
Cdd:cd18011 155 RHVLLLTATPHNGKeedFRALLSLLD 180
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
307-500 |
1.42e-21 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 94.95 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWL---------ALVHKHGLNGILADEMGLGKTIQAIAFLAYLF---QEGNKGPHLIVVPASTIDNWLREV 374
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 375 NLWCPSLN--------VLCYYGSQEERkqiRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKL-------------N 433
Cdd:cd18068 81 EKWQEGLKdeekievnELATYKRPQER---SYKLQRWQEEGGVMIIGYDMYRILAQERNVKSREKLkeifnkalvdpgpD 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358438428 434 YAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMF 500
Cdd:cd18068 158 FVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIK-EFRNRF 223
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
307-532 |
2.54e-21 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 94.08 E-value: 2.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLALVHKHGLNG-ILADEMGLGKTIQAIAFLayLFQEGNK-------------------------GPHLI 360
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTQnrkeeekekalteweskkdstlvpsAGTLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 361 VVPASTIDNWLREVNLWCPS--LNVLCYYGSQEERKQIRFnihnkyEDYNVIVTTYNCAIS------SSDDRSLFRRLKL 432
Cdd:cd18072 79 VCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVL------RDYDIVITTYSLVAKeiptykEESRSSPLFRIAW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 433 NYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstseirrmFSSKTKPADEQSI 512
Cdd:cd18072 153 ARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDD--------LKVWKKQVDNKSR 224
|
250 260
....*....|....*....|
gi 358438428 513 YEKERIAhakQIIKPFILRR 532
Cdd:cd18072 225 KGGERLN---ILTKSLLLRR 241
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
694-777 |
1.34e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 83.80 E-value: 1.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 694 DILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMdiFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRC 773
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 358438428 774 HRVG 777
Cdd:smart00490 79 GRAG 82
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
305-469 |
7.20e-11 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 61.53 E-value: 7.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 305 LSLKPYQKVGL-NWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDN-WLREVNLWCPSLN 382
Cdd:pfam04851 2 LELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEqALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 383 VLCYYGSQEERKQIrfnihnkYEDYNVIVTTYNCAISSSDDRSL-FRRLKLNYAIFDEGHMLknmGSIRYQHLMTINARN 461
Cdd:pfam04851 82 EIGEIISGDKKDES-------VDDNKIVVTTIQSLYKALELASLeLLPDFFDVIIIDEAHRS---GASSYRNILEYFKPA 151
|
....*....
gi 358438428 462 RLL-LTGTP 469
Cdd:pfam04851 152 FLLgLTATP 160
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
307-477 |
1.20e-10 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 61.98 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGLNWLAlvhKHGLNGILADeMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTI-DNWLREVNLW--CPSLNV 383
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVArSTWPDEVEKWnhLRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 384 LCYYGSQEERkqirfnihNKYEDYNVIVTTYN-----CAISSSDDRSLFRRLklnyaIFDEGHMLKNMGSIRYQHLMTIN 458
Cdd:cd18013 77 SVAVGTERQR--------SKAANTPADLYVINrenlkWLVNKSGDPWPFDMV-----VIDELSSFKSPRSKRFKALRKVR 143
|
170 180
....*....|....*....|.
gi 358438428 459 AR-NRLL-LTGTPVQNNLLEL 477
Cdd:cd18013 144 PViKRLIgLTGTPSPNGLMDL 164
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
304-470 |
1.50e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 61.58 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 304 SLSLKPYQKVGLN-WLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFqegNKGPHLIVVPASTI-DNWLREVnlwcpsl 381
Cdd:COG1061 78 SFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTVLALALAAELL---RGKRVLVLVPRRELlEQWAEEL------- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 382 nvlcyygsQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLnyAIFDEGHmlkNMGSIRYQHLMT-INAR 460
Cdd:COG1061 148 --------RRFLGDPLAGGGKKDSDAPITVATYQSLARRAHLDELGDRFGL--VIIDEAH---HAGAPSYRRILEaFPAA 214
|
170
....*....|
gi 358438428 461 NRLLLTGTPV 470
Cdd:COG1061 215 YRLGLTATPF 224
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
307-469 |
2.05e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 56.93 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 307 LKPYQKVGL-NWLAlvHKHGLNGILADEMGLGKTIQAIAFLAYLFQEgnkgPHLIVVP-ASTIDNWLREvnlwcpslnvL 384
Cdd:cd17926 1 LRPYQEEALeAWLA--HKNNRRGILVLPTGSGKTLTALALIAYLKEL----RTLIVVPtDALLDQWKER----------F 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 385 CYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLnYAIFDEGHmlkNMGSIRYQHLMTI-NARNRL 463
Cdd:cd17926 65 EDFLGDSSIGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQFG-LLIVDEAH---HLPAKTFSEILKElNAKYRL 140
|
....*.
gi 358438428 464 LLTGTP 469
Cdd:cd17926 141 GLTATP 146
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
327-468 |
6.61e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 49.71 E-value: 6.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 327 NGILADEMGLGKTIQAIAFLAYLFqEGNKGPHLIVVPASTIDN----WLREvnLWCPSLNVLCYYG--SQEERKQIRFNi 400
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAALLLL-LKKGKKVLVLVPTKALALqtaeRLRE--LFGPGIRVAVLVGgsSAEEREKNKLG- 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 358438428 401 hnkyeDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHML------KNMGSIRYQHLMTINARnRLLLTGT 468
Cdd:cd00046 79 -----DADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlidsrgALILDLAVRKAGLKNAQ-VILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
335-472 |
2.78e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 45.31 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 335 GLGKTiqAIAFLAYL--FQEGNKGPH-LIVVP--------ASTIDNWLREVNLwcpslNVLCYYGSQEERKQIRfnihnK 403
Cdd:pfam00270 24 GSGKT--LAFLLPALeaLDKLDNGPQaLVLAPtrelaeqiYEELKKLGKGLGL-----KVASLLGGDSRKEQLE-----K 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 358438428 404 YEDYNVIVTTYNCAISSSDDRSLFRRLKlnYAIFDEGHMLKNMGsiRYQHLMTI-----NARNRLLLTGTPVQN 472
Cdd:pfam00270 92 LKGPDILVGTPGRLLDLLQERKLLKNLK--LLVLDEAHRLLDMG--FGPDLEEIlrrlpKKRQILLLSATLPRN 161
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
664-755 |
2.11e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 39.54 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 664 GKFRALGCILSELKQkGDRVVLFSQFTMMLD-ILEVLLKhhqhrYLrLDGKTQISERIHLIDEF-----NTdmdIFVfll 737
Cdd:cd18789 34 NKLRALEELLKRHEQ-GDKIIVFTDNVEALYrYAKRLLK-----PF-ITGETPQSEREEILQNFregeyNT---LVV--- 100
|
90
....*....|....*...
gi 358438428 738 sTKAGGLGINLTSANVVI 755
Cdd:cd18789 101 -SKVGDEGIDLPEANVAI 117
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
330-471 |
4.96e-03 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 40.59 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 330 LADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWL----REVNLWcPSLnvlcyygSQEERkqirfNIHNKYE 405
Cdd:PRK04914 174 LADEVGLGKTIEAGMIIHQQLLTGRAERVLILVPETLQHQWLvemlRRFNLR-FSL-------FDEER-----YAEAQHD 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358438428 406 DYNVIVTTyNCAISSSDdrsLFRRLKLNY----------AIFDEGHML---KNMGSIRYQHLMTINARNR--LLLTGTPV 470
Cdd:PRK04914 241 ADNPFETE-QLVICSLD---FLRRNKQRLeqalaaewdlLVVDEAHHLvwsEEAPSREYQVVEQLAEVIPgvLLLTATPE 316
|
.
gi 358438428 471 Q 471
Cdd:PRK04914 317 Q 317
|
|
| |
