BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  33 LVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNT-PCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQC 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 384875329 112 LNIQG 116
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  33 LVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNT-PCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQC 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 384875329 112 LNIQG 116
Cdd:cd18315   81 LQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329   27 LRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPV--VMLAGVNANDLEALLEFVYRGEVsVDHAQLPS 104
Cdd:pfam00651   4 LREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKL-ISEENVDD 82

                          90
                  ....*....|...
gi 384875329  105 LLQAAQCLNIQGL 117
Cdd:pfam00651  83 LLAAADKLQIPSL 95

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  33 LVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNT-PCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQC 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 384875329 112 LNIQG 116
Cdd:cd18315   81 LQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329   27 LRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPV--VMLAGVNANDLEALLEFVYRGEVsVDHAQLPS 104
Cdd:pfam00651   4 LREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKL-ISEENVDD 82

                          90
                  ....*....|...
gi 384875329  105 LLQAAQCLNIQGL 117
Cdd:pfam00651  83 LLAAADKLQIPSL 95

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329    35 DCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC--KHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCL 112
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*.
gi 384875329   113 NIQGLA 118
Cdd:smart00225  81 QIPGLV 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  27 LRCHGDLVDCTLAAGGRSFPAHKIVLCAASP-----FLLDLLKntpCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQ 101
Cdd:cd18247   13 IRRQGKLCDVTLKVGDQKFSAHRIVLAATIPyfhamFTHDMVE---SKQDEITMQGIEPSALEALINFAYSGRIAIDTSN 89

                         90
                 ....*....|....
gi 384875329 102 LPSLLQAAQCLNIQ 115
Cdd:cd18247   90 VQSLLVGASFLQLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  19 SLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNT--PCKHPVVMLAGVNANDLEALLEFVYRGEVS 96
Cdd:cd18250    7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGElrESRADRVVLHGVSAEILGLLLDFSYTGRVT 86

                         90
                 ....*....|...
gi 384875329  97 VDHAQLPSLLQAA 109
Cdd:cd18250   87 VTQDNVEALLRAA 99

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  25 QLLRC--HGDLVdcTLAAGGRSFPAHKIVLCAASPFLLDLLkntpCKHPVVML-AGVNANDLEALLEFVYRGEVSVDHAQ 101
Cdd:cd18299    5 NLLHSpsCADVV--FILQGGVRIFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                         90
                 ....*....|....*.
gi 384875329 102 LPSLLQAAQCLNIQGL 117
Cdd:cd18299   79 LKELKDAAELLELFDL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKN--TPCKHPVVMLAGVNANDLEALLEFVYRG 93
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmRESSQDEIELKGVSAKGLKHILDFAYTS 80

                         90
                 ....*....|....*.
gi 384875329  94 EVSVDHAQLPSLLQAA 109
Cdd:cd18255   81 ELTLDLDCIQDVLGAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  16 YGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCK--HPVVMLAGVNANDLEALLEFVYRG 93
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYTG 82

                         90
                 ....*....|....*....
gi 384875329  94 EVSVDHAQLPSLLQAAQCL 112
Cdd:cd18256   83 VVEVTVSNVQELLVAADML 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  24 IQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASP-----FLLDLlknTPCKHPVVMLAGVNANDLEALLEFVYRGEVSVD 98
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPyframFTSEM---AESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                         90       100
                 ....*....|....*....|
gi 384875329  99 HAQLPSLLQAAQCLNIQGLA 118
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVA 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  27 LRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNtPCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLL 106
Cdd:cd18218   12 LRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN-PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRPLL 90

                         90
                 ....*....|....
gi 384875329 107 QAAQCLNIQGLAPQ 120
Cdd:cd18218   91 EAARALEVESLEEA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  18 TSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKN--TPCKHPVVMLAGVNANDLEALLEFVYRGEV 95
Cdd:cd18253    3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNdhRESREMLVEINGILAEAMDCFLQYVYTGKV 82

                         90       100
                 ....*....|....*....|..
gi 384875329  96 SVDHAQLPSLLQAAQCLNIQGL 117
Cdd:cd18253   83 KITTENVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  35 DCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTP---CKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQC 111
Cdd:cd18293   17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPppaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARR 96

                 ....*.
gi 384875329 112 LNIQGL 117
Cdd:cd18293   97 LQISEL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  25 QLLRC------HGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAG--VNANDLEALLEFVYRGEVS 96
Cdd:cd18194    9 QLLQClreqrsQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSdiVTAPAFGLLLDFMYEGRLA 88

                         90
                 ....*....|....*...
gi 384875329  97 VDHAQLPSLLQAAQCLNI 114
Cdd:cd18194   89 LRDLPVEDVLAAASYLHM 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  20 LVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC-KHPVVMLAGVNANDLEALLEFVYRGEVSVD 98
Cdd:cd18233    5 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSqKNDVFHLDIKNVGGIGQILDFMYTSHLDLN 84

                         90
                 ....*....|....*..
gi 384875329  99 HAQLPSLLQAAQCLNIQ 115
Cdd:cd18233   85 QDNVQVMLDIAQCLQVQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC--KHPVVMLAGVNANDLEALLEFVYR 92
Cdd:cd18326    7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDFVSAEALTALLDFAYT 86

                         90       100
                 ....*....|....*....|...
gi 384875329  93 GEVSVDHAQLPSLLQAAQCLNIQ 115
Cdd:cd18326   87 ATLTVSTSNVGDILSAARLLEIP 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVVMLAG--VNANDLEALLEFVYR 92
Cdd:cd18323    5 DHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNeiVTAPAFSLLLEFMYE 84

                         90       100
                 ....*....|....*....|..
gi 384875329  93 GEVSVDHAQLPSLLQAAQCLNI 114
Cdd:cd18323   85 GRLSFNDTPVEDVLAAASYLHM 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  23 AIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNT----PCKHPVVMLAGvnandLEALLEFVYRGEVSVD 98
Cdd:cd18262    8 EAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSngplPPLSLEVTPVG-----WEAVLTFAYTGVLGRN 82

                         90
                 ....*....|....
gi 384875329  99 HAQLPSLLQAAQCL 112
Cdd:cd18262   83 PATVGDILVAAEAL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLD--LLKNTpckHPVVMLAGVNANDLEALLEFVYR 92
Cdd:cd18227    7 DFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvLLKNS---RRIVLPDVMNPRVFENILLSCYT 83

                         90       100
                 ....*....|....*....|..
gi 384875329  93 GEVSVDHAQLPSLLQAAQCLNI 114
Cdd:cd18227   84 GRLVLPAPEIVSYLTAASFLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  33 LVDCTLAAGGRSFPAHKIVLCAASP-FLLDLLKNTPCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQC 111
Cdd:cd18212   23 LCDITLIVENVQFRAHKALLAASSEyFSMMFADEGEVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQF 102

                 ....*.
gi 384875329 112 LNIQGL 117
Cdd:cd18212  103 LKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  30 HGDLVDCTLAAGGRSFPAHKIVLCAASP-----FLLDLlknTPCKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPS 104
Cdd:cd18340   24 HNKFVDCVLKIKEKEFPCHRLVLAACSPyframFLSDL---EESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQD 100

                         90
                 ....*....|
gi 384875329 105 LLQAAQCLNI 114
Cdd:cd18340  101 IFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  33 LVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPC--KHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAq 110
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReaTEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATA- 79

                 ..
gi 384875329 111 CL 112
Cdd:cd18234   80 CL 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  32 DLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTP-----CKHPVVMLAGVNANDLEALLEFVYRGEVSVDHAQLPSLL 106
Cdd:cd18258   16 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSrdsggGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLL 95

                 ...
gi 384875329 107 QAA 109
Cdd:cd18258   96 EAA 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384875329  27 LRCHGDLVDCTLAAGGR----SFPAHKIVLCAASPFLLDLLKN--TPCKHPVVMLAGVNANDLEALLEFVYRGEVSV 97
Cdd:cd18248   15 LRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSglRECGMEVVPIEGVHPCVMSRLIEFAYTASISV 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKhPVVMLAGVNANDLEALLEFVYRGE 94
Cdd:cd18290    9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA-VVELPAAVQPQSFQQILSFCYTGR 87

                         90       100
                 ....*....|....*....|.
gi 384875329  95 VSVDHAQLPSLLQAAQCLNIQ 115
Cdd:cd18290   88 LSMNVGDQFLLMYTAGFLQIQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  31 GDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKN---TPCKHPVVMLagvNANDL-----EALLEFVYRGEVSVDHAQL 102
Cdd:cd18292   15 EELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdwwSESKQSEIEL---VEDPEcaavfEKFLRYLYTGQISVNLETA 91

                         90
                 ....*....|....*
gi 384875329 103 PSLLQAAQCLNIQGL 117
Cdd:cd18292   92 LPLLMLADKYNVTDL 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  19 SLVSAIQLLRCHGDLVDCTLAA---GGRS-FPAHKIVLCAASPFLLDLLKN---TPCKHPVVMLAGVNANDLEALLEFVY 91
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVehqGSKEeFSAHKAVLAASSKYFKEVFLNekiSDGKNTNVMLNEIYTADFASFLEFVY 90

                         90       100
                 ....*....|....*....|....*..
gi 384875329  92 RGEVSVDHAQLPSLLQAAQCLNIQGLA 118
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDLS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384875329  15 DYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHpvVMLAGVNANDLEALLEFVYRGE 94
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTIS--IDASVVSPEEFALLLEMVYTGK 82

                         90       100
                 ....*....|....*....|
gi 384875329  95 VSVDHAQLPSLLQAAQCLNI 114
Cdd:cd18225   83 LPPGKHNFTKIISVADSLQM 102