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Conserved domains on  [gi|3913771|sp|O46675|]
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RecName: Full=Growth-regulated protein homolog gamma; Short=GRO-gamma; Flags: Precursor

Protein Classification

CXC family chemokine (domain architecture ID 10084510)

CXC family chemokine such as interleukin-8, also called C-X-C motif chemokine 8, that is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes, and is involved in neutrophil activation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
36-98 1.05e-24

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


:

Pssm-ID: 238171  Cd Length: 64  Bit Score: 87.70  E-value: 1.05e-24
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3913771  36 ELRCQCLQTLQG-IHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKMLN 98
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
36-98 1.05e-24

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 87.70  E-value: 1.05e-24
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3913771  36 ELRCQCLQTLQG-IHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKMLN 98
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
36-96 1.33e-14

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 62.26  E-value: 1.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3913771     36 ELRCqCLQ-TLQGIHLKNIQSVKVTtpGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKM 96
Cdd:smart00199  1 PLRC-CLSyTSKKIPLKRIKSYYPT--SSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
37-96 1.37e-13

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 395003  Cd Length: 60  Bit Score: 59.58  E-value: 1.37e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3913771    37 LRCqCLQTLQG-IHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKM 96
Cdd:pfam00048  1 SDC-CLRYSSKpIPLKRVKSYEIQPPSSSCPKPAVIFLTKKGRQVCADPKQKWVQRLIKKL 60
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
36-98 1.05e-24

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 87.70  E-value: 1.05e-24
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3913771  36 ELRCQCLQTLQG-IHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKMLN 98
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
40-97 2.84e-17

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 68.90  E-value: 2.84e-17
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*....
gi 3913771  40 QCLQTL-QGIHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKML 97
Cdd:cd00169  1 CCLKYTsKPIPPKNIKSYRVQEAGGHCSIPAVIFTTKKGRKVCADPKEPWVKDLIQKLD 59
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
36-96 1.33e-14

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 62.26  E-value: 1.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3913771     36 ELRCqCLQ-TLQGIHLKNIQSVKVTtpGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKM 96
Cdd:smart00199  1 PLRC-CLSyTSKKIPLKRIKSYYPT--SSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
37-96 1.37e-13

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 395003  Cd Length: 60  Bit Score: 59.58  E-value: 1.37e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3913771    37 LRCqCLQTLQG-IHLKNIQSVKVTTPGPHCDQTEVIATLKTGQEVCLNPAAPMVKKIIDKM 96
Cdd:pfam00048  1 SDC-CLRYSSKpIPLKRVKSYEIQPPSSSCPKPAVIFLTKKGRQVCADPKQKWVQRLIKKL 60
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
41-98 1.30e-03

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 34.14  E-value: 1.30e-03
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*....
gi 3913771  41 CLQTLQG-IHLKNIQSVKVTTPGphCDQTEVIATLKTGQEVCLNPAAPMVKKIIdKMLN 98
Cdd:cd00272  2 CLSYSKKrIPLRVLKSYRRTSSS--CSKPAVIFKTKRGREVCADPKQKWVQRYM-KLLD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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