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Conserved domains on  [gi|401557298|gb|AFP94513|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Anopheles gambiae]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-124 2.24e-43

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00163:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 445  Bit Score: 146.84  E-value: 2.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00163 322 YERLGSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSY 401

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCMLW 124
Cdd:MTH00163 402 SQHGKYYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFMLW 445
 
Name Accession Description Interval E-value
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-124 2.24e-43

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 146.84  E-value: 2.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00163 322 YERLGSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSY 401

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCMLW 124
Cdd:MTH00163 402 SQHGKYYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFMLW 445
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-67 2.46e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 56.17  E-value: 2.46e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 401557298    1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLS 67
Cdd:pfam00361 224 YRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVG 290
 
Name Accession Description Interval E-value
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-124 2.24e-43

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 146.84  E-value: 2.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00163 322 YERLGSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSY 401

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCMLW 124
Cdd:MTH00163 402 SQHGKYYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFMLW 445
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 1-125 8.24e-28

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 104.92  E-value: 8.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00150 293 YEKVHSRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTS 372

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCMLWI 125
Cdd:MTH00150 373 IQHGGSSSFLKPFNELKSSEMLLLLLHWVPLLLLILKSDLLFMWI 417
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 1-122 5.25e-27

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 103.14  E-value: 5.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00205 326 YERTNSRSMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQ 405

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCM 122
Cdd:MTH00205 406 SQHGKVSSQISSFLAISEREYYILILHWFPLNILILKLKIFI 447
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-125 9.22e-24

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 94.42  E-value: 9.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00014 328 YETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYTS 407

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCMLWI 125
Cdd:MTH00014 408 TQHGSPPSFMNPLNLFTPRNHTLMTLHLVPLFILILKPDLITNWL 452
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-117 4.74e-20

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 84.09  E-value: 4.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00124 334 YERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLS 413

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILK 117
Cdd:MTH00124 414 TQRGTLPTHITTIQPTHTREHLLMTLHIIPLLLLILK 450
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-121 5.30e-19

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 81.14  E-value: 5.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00206 330 YERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYMFVM 409

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFC 121
Cdd:MTH00206 410 TQHGKTPNHLLSLSPSSTREHLLLFLHLFPVILLILNPNLI 450
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-123 2.01e-16

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 73.86  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00044 336 YERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIYQL 415

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILKSNFCML 123
Cdd:MTH00044 416 TNSGSFPSWISNVSPISSREHLLIFLHLLPLILIIINPNIILI 458
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-117 1.31e-15

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 71.49  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00068 334 YERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAAYTLYMFLM 413

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILK 117
Cdd:MTH00068 414 TQRGPLPNHLKTLFPTYTREHLLLALHILPMLLLILK 450
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-85 2.44e-15

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 70.69  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00110 334 YERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLIT 413


                 ....*
gi 401557298  81 SQHGK 85
Cdd:MTH00110 414 TQRGK 418
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-117 6.52e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 66.52  E-value: 6.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLFAY 80
Cdd:MTH00127 335 YERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAGYSLYMFLM 414

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 401557298  81 SQHGKIYSGVYFFSVGTTREFLLLMLHWLPLNLLILK 117
Cdd:MTH00127 415 TQRGPLPDHIIALNPSHTREHLLMALHLLPLLLLILK 451
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-67 2.46e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 56.17  E-value: 2.46e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 401557298    1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLS 67
Cdd:pfam00361 224 YRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVG 290
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-78 8.34e-06

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 43.51  E-value: 8.34e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLF 78
Cdd:MTH00204 351 YERHHTRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLY 428
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 1-78 4.32e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 38.49  E-value: 4.32e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401557298   1 YERMGSRSLLINKGLLNFMPTLSLWWFLLCSGNMAAPPTLNLLGEISLLNSIVSWSWITMIMLSFLSFFSAAYSLYLF 78
Cdd:MTH00217 348 YERHHTRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYLY 425
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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