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Conserved domains on  [gi|4033763|sp|O00410|]
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RecName: Full=Importin-5; Short=Imp5; AltName: Full=Importin subunit beta-3; AltName: Full=Karyopherin beta-3; AltName: Full=Ran-binding protein 5; Short=RanBP5

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
765-874 1.23e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


:

Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.23e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 4033763     845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
268-357 1.44e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


:

Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 4033763     348 CGLGGKLVLP 357
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
13-634 2.00e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215    9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215   89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215  164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215  230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215  309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215  379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215  459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215  535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 4033763   595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215  615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
Importin_rep_5 super family cl40106
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1005-1051 3.04e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


The actual alignment was detected with superfamily member pfam18816:

Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4033763    1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
919-966 6.48e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 4033763     919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
765-874 1.23e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.23e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 4033763     845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
268-357 1.44e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 4033763     348 CGLGGKLVLP 357
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
13-634 2.00e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215    9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215   89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215  164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215  230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215  309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215  379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215  459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215  535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 4033763   595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215  615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
372-426 4.34e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 4.34e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4033763     372 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 426
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1005-1051 3.04e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4033763    1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
919-966 6.48e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 4033763     919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
765-874 1.23e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.23e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 4033763     845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
268-357 1.44e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 4033763     348 CGLGGKLVLP 357
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
13-634 2.00e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215    9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763    83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215   89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215  164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215  230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215  309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215  379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215  459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215  535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 4033763   595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215  615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
372-426 4.34e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 4.34e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4033763     372 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 426
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
352-466 9.57e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.02  E-value: 9.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   352 GKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfa 431
Cdd:COG1413   41 GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGD--- 107
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 4033763   432 pgfqkkfhEKVIAALLQTMEDQgNQRVQAHAAAAL 466
Cdd:COG1413  108 --------PAAVPALLEALKDP-DWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
361-484 5.64e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.71  E-value: 5.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   361 EHIMQMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhE 440
Cdd:COG1413   19 PALIAALADEDPDVRAAAARALGRLGDP----------RAVPALLEALKDPDPEVRAAAAEALGRIGD-----------P 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 4033763   441 KVIAALLQTMEDQgNQRVQAHAAAALINFTEDCPKSLLIPYLDN 484
Cdd:COG1413   78 EAVPALIAALKDE-DPEVRRAAAEALGRLGDPAAVPALLEALKD 120
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
365-466 1.37e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 50.03  E-value: 1.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763     365 QMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIA 444
Cdd:pfam13646    7 ALLRDPDPEVRAAAIRALGRIGDP----------EAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65
                           90       100
                   ....*....|....*....|..
gi 4033763     445 ALLQTMEDQGNQRVQAHAAAAL 466
Cdd:pfam13646   66 ALLELLRDDDDDVVRAAAAEAL 87
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1005-1051 3.04e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4033763    1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
Vac14_Fab1_bd pfam12755
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ...
374-422 1.46e-05

Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 403838  Cd Length: 97  Bit Score: 44.51  E-value: 1.46e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4033763     374 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNA 422
Cdd:pfam12755    2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
HEAT COG1413
HEAT repeat [General function prediction only];
375-484 9.11e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 9.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4033763   375 RHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMAtdfapgfqkkfHEKVIAALLQTMEDQg 454
Cdd:COG1413    2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDP- 59
                         90       100       110
                 ....*....|....*....|....*....|
gi 4033763   455 NQRVQAHAAAALINFTEDCPKSLLIPYLDN 484
Cdd:COG1413   60 DPEVRAAAAEALGRIGDPEAVPALIAALKD 89
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
400-427 5.74e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 38.28  E-value: 5.74e-04
                           10        20
                   ....*....|....*....|....*...
gi 4033763     400 IVNFVLLFLQDPHPRVRYAACNAVGQMA 427
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
919-966 6.48e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 4033763     919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
413-469 1.20e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 4033763     413 PRVRYAACNAVGQMAtDFAPGFQKKFHEKVIAALLQTMEDqGNQRVQAHAAAALINF 469
Cdd:pfam13513    1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
361-427 1.46e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4033763   361 EHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMA 427
Cdd:COG1413   81 PALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
IBN_N pfam03810
Importin-beta N-terminal domain;
44-94 2.64e-03

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 37.60  E-value: 2.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 4033763      44 FLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELL 94
Cdd:pfam03810   17 KLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKNSLPPEEKEQIKNNLL 67
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
906-935 5.73e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 5.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 4033763     906 FLRPMLQYVCDNSPEVRQAAAYGLGVMAQY 935
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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