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Conserved domains on  [gi|40745217|gb|EAA64373|]
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hypothetical protein AN9041.2 [Aspergillus nidulans FGSC A4]

Protein Classification

MaoC family dehydratase( domain architecture ID 11973509)

MaoC family dehydratase similar to Arabidopsis thaliana peroxisomal enoyl-CoA hydratase 2, which catalyzes a hydration step in peroxisomal beta-oxidation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 164-286 8.78e-60

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


:

Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 186.66  E-value: 8.78e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 164 PSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRL 243
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRL-SGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADGDPARFKAIKVRF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 40745217 244 SKPVFPGEVVTTKMWRFNETKIVYQQVAGDGRVVISNAEIKLK 286
Cdd:cd03448  80 SSPVFPGETLRTEMWKEGNRVIFQTKVVERDVVVLSNGAALLA 122
PLN02864 super family cl28571
enoyl-CoA hydratase
 13-279 3.42e-43

enoyl-CoA hydratase


The actual alignment was detected with superfamily member PLN02864:

Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 150.32  E-value: 3.42e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   13 TSITYDASNIITYNLSVGSKGQD------LRHCWEE--HPEFQALPTFSSLAVIDIMGKVTVDMPKLLplYKPSQHphVH 84
Cdd:PLN02864  21 VTYSYTERDVALYALGVGACGRDavdedeLKYVYHRdgQQFIKVLPTFASLFNLGSLDGFGLDLPGLN--YDPSLL--LH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   85 AEHSLEIRGPLPRSGTLTSEARILDVVDRrtGVALIVGISIR--NEDTGEWICYSEWTSFLM--------KMPGDGASKA 154
Cdd:PLN02864  97 GQQYIEIYKPIPSSASVRNKVSIAGLHDK--GKAAILELETLsyEKDSGELLCMNRSTIFLRgaggfsnsSQPFSYSNYP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217  155 SSSMQSTLLPSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSA 234
Cdd:PLN02864 175 TNQVSAVKIPKSQPDAVFEDQTQPSQALLYRL-SGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFCNGDPT 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 40745217  235 RFQRLKLRLSKPVFPGEVVTTKMWrFNETKIVYQ-QVAGDGRVVIS 279
Cdd:PLN02864 254 AVKTISGRFLLHVYPGETLVTEMW-LEGLRVIYQtKVKERNKAVLS 298
 
Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 164-286 8.78e-60

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 186.66  E-value: 8.78e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 164 PSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRL 243
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRL-SGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADGDPARFKAIKVRF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 40745217 244 SKPVFPGEVVTTKMWRFNETKIVYQQVAGDGRVVISNAEIKLK 286
Cdd:cd03448  80 SSPVFPGETLRTEMWKEGNRVIFQTKVVERDVVVLSNGAALLA 122
PLN02864 PLN02864
enoyl-CoA hydratase
 13-279 3.42e-43

enoyl-CoA hydratase


Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 150.32  E-value: 3.42e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   13 TSITYDASNIITYNLSVGSKGQD------LRHCWEE--HPEFQALPTFSSLAVIDIMGKVTVDMPKLLplYKPSQHphVH 84
Cdd:PLN02864  21 VTYSYTERDVALYALGVGACGRDavdedeLKYVYHRdgQQFIKVLPTFASLFNLGSLDGFGLDLPGLN--YDPSLL--LH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   85 AEHSLEIRGPLPRSGTLTSEARILDVVDRrtGVALIVGISIR--NEDTGEWICYSEWTSFLM--------KMPGDGASKA 154
Cdd:PLN02864  97 GQQYIEIYKPIPSSASVRNKVSIAGLHDK--GKAAILELETLsyEKDSGELLCMNRSTIFLRgaggfsnsSQPFSYSNYP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217  155 SSSMQSTLLPSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSA 234
Cdd:PLN02864 175 TNQVSAVKIPKSQPDAVFEDQTQPSQALLYRL-SGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFCNGDPT 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 40745217  235 RFQRLKLRLSKPVFPGEVVTTKMWrFNETKIVYQ-QVAGDGRVVIS 279
Cdd:PLN02864 254 AVKTISGRFLLHVYPGETLVTEMW-LEGLRVIYQtKVKERNKAVLS 298
MaoC_dehydratas pfam01575
MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the ...
 164-281 4.84e-30

MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.


Pssm-ID: 396243 [Multi-domain]  Cd Length: 123  Bit Score: 110.12  E-value: 4.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   164 PSREPDAVLSHQTTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRL 243
Cdd:pfam01575   6 PGEPPDTEKPRTVTEADIALFALVSGDHNPIHVDPEFAKKAGFGGPIAHGMLTLAIVAGLVEEWGGDNVIARFGEIKVRF 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 40745217   244 SKPVFPGEVVTTKMWRFNEtKIVYQQVAGDGRVVISNA 281
Cdd:pfam01575  86 TKPVFPGDTLRTEAEVVGK-RDGRQTKVVEVTVEVTEV 122
MaoC COG2030
Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];
177-258 2.36e-14

Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];


Pssm-ID: 441633 [Multi-domain]  Cd Length: 140  Bit Score: 68.76  E-value: 2.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 177 TPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRLSKPVFPGEVVTTK 256
Cdd:COG2030  19 TEEDIVLFAGATGDPNPIHLDEEAAAATGFGGRIAHGMLTLSLASGLLVDDLPGTAVANLGLQEVRFLRPVRVGDTLRAR 98


                ..
gi 40745217 257 MW 258
Cdd:COG2030  99 VE 100
PRK13693 PRK13693
(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional
 184-247 3.07e-04

(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional


Pssm-ID: 184249 [Multi-domain]  Cd Length: 142  Bit Score: 40.20  E-value: 3.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40745217  184 YRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFagGDSARFQRLKLRLSKPV 247
Cdd:PRK13693  30 YAGVSGDLNPIHWDDEIAKVVGLDTAIAHGMLTMGLGGGYVTSWV--GDPGAVTEYNVRFTAVV 91
 
Name Accession Description Interval E-value
HDE_HSD cd03448
HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), ...
 164-286 8.78e-60

HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.


Pssm-ID: 239532 [Multi-domain]  Cd Length: 122  Bit Score: 186.66  E-value: 8.78e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 164 PSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRL 243
Cdd:cd03448   1 PDRAPDAVVEIPTSPDQALLYRL-SGDYNPLHIDPAFAKAAGFPRPILHGLCTYGFAARAVLEAFADGDPARFKAIKVRF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 40745217 244 SKPVFPGEVVTTKMWRFNETKIVYQQVAGDGRVVISNAEIKLK 286
Cdd:cd03448  80 SSPVFPGETLRTEMWKEGNRVIFQTKVVERDVVVLSNGAALLA 122
PLN02864 PLN02864
enoyl-CoA hydratase
 13-279 3.42e-43

enoyl-CoA hydratase


Pssm-ID: 178455 [Multi-domain]  Cd Length: 310  Bit Score: 150.32  E-value: 3.42e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   13 TSITYDASNIITYNLSVGSKGQD------LRHCWEE--HPEFQALPTFSSLAVIDIMGKVTVDMPKLLplYKPSQHphVH 84
Cdd:PLN02864  21 VTYSYTERDVALYALGVGACGRDavdedeLKYVYHRdgQQFIKVLPTFASLFNLGSLDGFGLDLPGLN--YDPSLL--LH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   85 AEHSLEIRGPLPRSGTLTSEARILDVVDRrtGVALIVGISIR--NEDTGEWICYSEWTSFLM--------KMPGDGASKA 154
Cdd:PLN02864  97 GQQYIEIYKPIPSSASVRNKVSIAGLHDK--GKAAILELETLsyEKDSGELLCMNRSTIFLRgaggfsnsSQPFSYSNYP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217  155 SSSMQSTLLPSREPDAVLSHQTTPEQGALYRAaTGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSA 234
Cdd:PLN02864 175 TNQVSAVKIPKSQPDAVFEDQTQPSQALLYRL-SGDYNPLHSDPMFAKVAGFTRPILHGLCTLGFAVRAVIKCFCNGDPT 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 40745217  235 RFQRLKLRLSKPVFPGEVVTTKMWrFNETKIVYQ-QVAGDGRVVIS 279
Cdd:PLN02864 254 AVKTISGRFLLHVYPGETLVTEMW-LEGLRVIYQtKVKERNKAVLS 298
MaoC_dehydratas pfam01575
MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the ...
 164-281 4.84e-30

MaoC like domain; The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.


Pssm-ID: 396243 [Multi-domain]  Cd Length: 123  Bit Score: 110.12  E-value: 4.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217   164 PSREPDAVLSHQTTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRL 243
Cdd:pfam01575   6 PGEPPDTEKPRTVTEADIALFALVSGDHNPIHVDPEFAKKAGFGGPIAHGMLTLAIVAGLVEEWGGDNVIARFGEIKVRF 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 40745217   244 SKPVFPGEVVTTKMWRFNEtKIVYQQVAGDGRVVISNA 281
Cdd:pfam01575  86 TKPVFPGDTLRTEAEVVGK-RDGRQTKVVEVTVEVTEV 122
R_hydratase_like cd03441
(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl ...
 170-279 4.13e-23

(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel beta-sheet wrapped around a central alpha helix, referred to as a hot dog fold. The active site lies within a substrate-binding tunnel formed by the homodimer. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit.


Pssm-ID: 239525 [Multi-domain]  Cd Length: 127  Bit Score: 91.94  E-value: 4.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 170 AVLSHQTTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRLSKPVFP 249
Cdd:cd03441   4 DSSGRTVTEADIALFARLSGDPNPIHVDPEYAKAAGFGGRIAHGMLTLSLASGLLVQWLPGTDGANLGSQSVRFLAPVFP 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 40745217 250 GEVVTTKMW--------RFNETKIVYQQVAGDGRVVIS 279
Cdd:cd03441  84 GDTLRVEVEvlgkrpskGRGVVTVRTEARNQGGEVVLS 121
MaoC COG2030
Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];
177-258 2.36e-14

Acyl-CoA dehydratase PaaZ [Lipid transport and metabolism];


Pssm-ID: 441633 [Multi-domain]  Cd Length: 140  Bit Score: 68.76  E-value: 2.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 177 TPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFAGGDSARFQRLKLRLSKPVFPGEVVTTK 256
Cdd:COG2030  19 TEEDIVLFAGATGDPNPIHLDEEAAAATGFGGRIAHGMLTLSLASGLLVDDLPGTAVANLGLQEVRFLRPVRVGDTLRAR 98


                ..
gi 40745217 257 MW 258
Cdd:COG2030  99 VE 100
SAV4209_like cd03453
SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot ...
 163-256 2.13e-11

SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.


Pssm-ID: 239537 [Multi-domain]  Cd Length: 127  Bit Score: 60.41  E-value: 2.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 163 LPSREPdaVLSHQTTpeqgALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFagGDSARFQRLKLR 242
Cdd:cd03453   5 LPPLTP--PVSRADL----VRYAGASGDFNPIHYDEDFAKKVGLPGVIAHGMLTMGLLGRLVTDWV--GDPGRVVSFGVR 76

                        90
                ....*....|....
gi 40745217 243 LSKPVFPGEVVTTK 256
Cdd:cd03453  77 FTKPVPVPDTLTCT 90
FAS_MaoC cd03447
FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes ...
 176-257 5.51e-10

FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).


Pssm-ID: 239531 [Multi-domain]  Cd Length: 126  Bit Score: 56.13  E-value: 5.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 176 TTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIgVNHVIEA-FAGGDSARFQRLKLRLSKPVFPGEVVT 254
Cdd:cd03447  10 TAPASNEPYARVSGDFNPIHVSRVFASYAGLPGTITHGMYTSAA-VRALVETwAADNDRSRVRSFTASFVGMVLPNDELE 88


                ...
gi 40745217 255 TKM 257
Cdd:cd03447  89 VRL 91
SAV4209 cd03455
SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of ...
 184-255 2.61e-07

SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and gamma-proteobacterial members of this CD have, in addition to a hot dog fold, an N-terminal extension.


Pssm-ID: 239539 [Multi-domain]  Cd Length: 123  Bit Score: 48.47  E-value: 2.61e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40745217 184 YRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFagGDSARFQRLKLRLSKPVFPGEVVTT 255
Cdd:cd03455  19 YSAATRDFHRIHHDRDYARAVGYPDLYVNGPTLAGLVIRYVTDWA--GPDARVKSFAFRLGAPLYAGDTLRF 88
R_hydratase cd03449
(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA ...
 172-254 1.86e-06

(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase II, and beta-hydroxydecanoyl-ACP dehydratase, MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit. The active site lies within a substrate-binding tunnel formed by the (R)-hydratase homodimer. A subset of the bacterial (R)-hydratases contain a C-terminal phosphotransacetylase (PTA) domain.


Pssm-ID: 239533 [Multi-domain]  Cd Length: 128  Bit Score: 46.38  E-value: 1.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 172 LSHQTTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIgVNHVIEAFAGGDSARFQRLKLRLSKPVFPGE 251
Cdd:cd03449   9 LTRTITEEDVELFAELSGDFNPIHLDEEYAKKTRFGGRIAHGMLTASL-ISAVLGTLLPGPGTIYLSQSLRFLRPVFIGD 87


                ...
gi 40745217 252 VVT 254
Cdd:cd03449  88 TVT 90
PRK13693 PRK13693
(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional
 184-247 3.07e-04

(3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional


Pssm-ID: 184249 [Multi-domain]  Cd Length: 142  Bit Score: 40.20  E-value: 3.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40745217  184 YRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFagGDSARFQRLKLRLSKPV 247
Cdd:PRK13693  30 YAGVSGDLNPIHWDDEIAKVVGLDTAIAHGMLTMGLGGGYVTSWV--GDPGAVTEYNVRFTAVV 91
PRK08190 PRK08190
bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
 170-283 5.40e-04

bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated


Pssm-ID: 236180 [Multi-domain]  Cd Length: 466  Bit Score: 41.40  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217  170 AVLSHQTTPEQGALYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIgvnhvIEAFAG----GDSARFQRLKLRLSK 245
Cdd:PRK08190  20 ASLVRTLTPDDIELFAAMSGDVNPAHLDAAYAASDGFHHVVAHGMWGGAL-----ISAVLGtrlpGPGTIYLGQSLRFRR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 40745217  246 PVFPGEVVTTKMW---RFNETKIVY---QQVAGDGRVVIS-NAEI 283
Cdd:PRK08190  95 PVRIGDTLTVTVTvreKDPEKRIVVldcRCTNQDGEVVITgTAEV 139
MaoC_dehydrat_N pfam13452
N-terminal half of MaoC dehydratase; It is clear from the structures of bacterial members of ...
 183-256 1.42e-03

N-terminal half of MaoC dehydratase; It is clear from the structures of bacterial members of MaoC dehydratase, pfam01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerize to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.


Pssm-ID: 433220 [Multi-domain]  Cd Length: 132  Bit Score: 38.06  E-value: 1.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40745217   183 LYRAATGEWNPMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAFA-GGDSARF----QRLKLRlsKPVFPGEVVTTK 256
Cdd:pfam13452  21 EFARAIGETNPAYWDEAAARAAGYGDLPAPPTFLFVLGWDAPGFMEQlGIDLSRLlhgeQRFTYH--RPLRAGDELTCR 97
YdeM cd03454
YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown ...
 193-257 2.01e-03

YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.


Pssm-ID: 239538 [Multi-domain]  Cd Length: 140  Bit Score: 37.93  E-value: 2.01e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40745217 193 PMHIDPATAQRAGFPGPILSGTCTIGIGVNHVIEAF----AGGDSARFQrlKLRLSKPVFPGEVVTTKM 257
Cdd:cd03454  33 PFHLDEEAAKESLFGGLAASGWHTAAITMRLLVDAGlsgsASGGSPGID--ELRWPRPVRPGDTLSVEV 99
MaoC_like cd03446
MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but ...
 188-295 4.17e-03

MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.


Pssm-ID: 239530 [Multi-domain]  Cd Length: 140  Bit Score: 36.90  E-value: 4.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40745217 188 TGEWNPMHIDPATAQRAGFPGPILSGTCTI---------GIGVNHVIEAFAGGDsarfqrlKLRLSKPVFPGEVVTTkmw 258
Cdd:cd03446  30 SGDWNPIHTDAEYAKKTRFGERIAHGLLTLsiatgllqrLGVFERTVVAFYGID-------NLRFLNPVFIGDTIRA--- 99

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 40745217 259 rfnETKIVYQQVAGDGRVVISNAEIKLKaggKQRSQL 295
Cdd:cd03446 100 ---EAEVVEKEEKDGEDAGVVTRRIEVV---NQRGEV 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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