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Conserved domains on  [gi|40949903|gb|AAR97575|]
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brain specific protein 4 [Mus musculus]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 13671257)

protein containing domains DENN, dDENN, and PPR_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 39-223 3.88e-78

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 254.81  E-value: 3.88e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903     39 RSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLP 118
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903    119 LSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFI 198
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 40949903    199 VGIHSSYFDL-HDPPADVICVDLDTN 223
Cdd:pfam02141  161 IGVHSRYFDLlEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 288-361 3.92e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 91.20  E-value: 3.92e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40949903     288 EREVQGAFLRFMACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 361
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
PPR_2 super family cl38385
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 536-576 9.88e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


The actual alignment was detected with superfamily member pfam13041:

Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 9.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 40949903    536 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 576
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 39-223 3.88e-78

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 254.81  E-value: 3.88e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903     39 RSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLP 118
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903    119 LSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFI 198
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 40949903    199 VGIHSSYFDL-HDPPADVICVDLDTN 223
Cdd:pfam02141  161 IGVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 40-223 1.15e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 208.20  E-value: 1.15e-61
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903      40 SRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHrLPLEAHISHFIHnvPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPL 119
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN-LPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903     120 SGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIV 199
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 40949903     200 GIHSSYFDLHDPP--ADVICVDLDTN 223
Cdd:smart00799  158 GVHSSYFEEVKELpdEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 288-361 3.92e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 91.20  E-value: 3.92e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40949903     288 EREVQGAFLRFMACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 361
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 328-377 3.08e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 3.08e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 40949903    328 FYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 377
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 536-576 9.88e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 9.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 40949903    536 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 576
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 39-223 3.88e-78

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 254.81  E-value: 3.88e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903     39 RSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLP 118
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903    119 LSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFI 198
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 40949903    199 VGIHSSYFDL-HDPPADVICVDLDTN 223
Cdd:pfam02141  161 IGVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 40-223 1.15e-61

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 208.20  E-value: 1.15e-61
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903      40 SRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHrLPLEAHISHFIHnvPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPL 119
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN-LPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903     120 SGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIV 199
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 40949903     200 GIHSSYFDLHDPP--ADVICVDLDTN 223
Cdd:smart00799  158 GVHSSYFEEVKELpdEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 288-361 3.92e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 91.20  E-value: 3.92e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40949903     288 EREVQGAFLRFMACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 361
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 328-377 3.08e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 3.08e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 40949903    328 FYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 377
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 122-226 4.48e-06

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 46.90  E-value: 4.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40949903    122 ASFLQLLQNLGPELaITLLLAVLTEHKLLVHSlRPDLLTSVCE------ALVSMIFPLH-WQCPYIPLCPLVLADVLSAP 194
Cdd:pfam08616    2 HSLLKLLGPFTPPI-ILLINALLTSKRIIFLS-YQRSAGEVSEfvlalcNLISGGFVLRgFTNNSFPYVDLSKLDALRKV 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 40949903    195 VPFIVGIHSSYFDLHDPPADVICvDLDTNTLF 226
Cdd:pfam08616   80 PGYIAGVTNPIFENQDQWWDVLC-DLDSGSVK 110
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 536-576 9.88e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 9.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 40949903    536 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 576
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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