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Conserved domains on  [gi|41053776|ref|NP_956547|]
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fizzy/cell division cycle 20 related 1a [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
202-474 5.85e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.87  E-value: 5.85e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 202 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAW 281
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 282 NAD--QLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAA 359
Cdd:COG2319 171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 360 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQV 438
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 41053776 439 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
202-474 5.85e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.87  E-value: 5.85e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 202 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAW 281
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 282 NAD--QLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAA 359
Cdd:COG2319 171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 360 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQV 438
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 41053776 439 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-473 2.29e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 2.29e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 195 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGH 272
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 273 TARVGALAWNADQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPM 350
Cdd:cd00200  93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 351 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILV 429
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 41053776 430 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 473
Cdd:cd00200 246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-343 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053776    304 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 343
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
306-343 1.43e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41053776   306 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 343
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 298-484 4.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776  298 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASg 376
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776  377 gGTADRCIRFWNTLTAQPLQCIDTGSQVCNLAWSKHTNELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 454
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 41053776  455 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 484
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
202-474 5.85e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.87  E-value: 5.85e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 202 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAW 281
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 282 NAD--QLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAA 359
Cdd:COG2319 171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 360 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQV 438
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 41053776 439 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
211-474 2.26e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 2.26e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 211 VYLWSACTSQVTRlcDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWNAD--QLSS 288
Cdd:COG2319 144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 289 GSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPH 368
Cdd:COG2319 222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 369 QHgLLASGGgtADRCIRFWNTLTAQPLQCID-TGSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 447
Cdd:COG2319 300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*..
gi 41053776 448 VLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
227-474 8.30e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 8.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 227 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWNAD--QLSSGSRDRMILQRDIRTPP 304
Cdd:COG2319  74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGK 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 305 LQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCI 384
Cdd:COG2319 154 LL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGS--ADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 385 RFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 463
Cdd:COG2319 229 RLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       250
                ....*....|.
gi 41053776 464 AGDETLRFWNV 474
Cdd:COG2319 307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-473 2.29e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 2.29e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 195 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGH 272
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 273 TARVGALAWNADQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPM 350
Cdd:cd00200  93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 351 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSKHTNELVSthGYSQNQILV 429
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 41053776 430 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 473
Cdd:cd00200 246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-474 7.10e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 7.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 232 DSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWNAD--QLSSGSRDRMILQRDIRTPplQSER 309
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLWDLETG--ECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 310 RLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNT 389
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSS--QDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 390 LTAQPLQCIdTG--SQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE 467
Cdd:cd00200 165 RTGKCVATL-TGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                ....*..
gi 41053776 468 TLRFWNV 474
Cdd:cd00200 242 TIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
213-474 3.91e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 3.91e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 213 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWNAD--QLSSGS 290
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 291 RDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQH 370
Cdd:COG2319  98 ADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 371 gLLASGGgtADRCIRFWNTLTAQPLQCID-TGSQVCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVL 449
Cdd:COG2319 176 -LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       250       260
                ....*....|....*....|....*
gi 41053776 450 YLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 266-474 2.37e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.37e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 266 LFALEGHTARVGALAWNADQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 343
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 344 HSSVLPMQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTAQPLQCIDT-GSQVCNLAWSkHTNELVSThGY 422
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 41053776 423 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
202-389 6.55e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 6.55e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 202 VLSVGLGTCVYLWSActSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAW 281
Cdd:COG2319 219 LASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 282 NAD--QLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAA 359
Cdd:COG2319 297 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                       170       180       190
                ....*....|....*....|....*....|
gi 41053776 360 VKAIAWSPHQHgLLASGGgtADRCIRFWNT 389
Cdd:COG2319 375 VTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
238-474 2.14e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 2.14e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 238 GWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 317
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 318 VCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTAQPLQC 397
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGS--ADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41053776 398 IDTGSQ-VCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 474
Cdd:COG2319 158 LTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 307-474 1.14e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 1.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 307 SERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRF 386
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS---DKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 387 WNTLTAQPLQCIdTG--SQVCNLAWSKHtNELVSThGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 464
Cdd:cd00200  78 WDLETGECVRTL-TGhtSYVSSVAFSPD-GRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                       170
                ....*....|
gi 41053776 465 GDETLRFWNV 474
Cdd:cd00200 155 QDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
324-476 8.74e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 8.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776 324 STDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRciRFWNTLTAQPLQCIDTGSQ 403
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL--LLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053776 404 VCNLAWSKHTNELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 476
Cdd:COG2319  81 VLSVAFSPDGRLLAS--ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-343 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053776    304 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 343
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
306-343 1.43e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41053776   306 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 343
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 434-473 3.29e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053776    434 SLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 473
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 298-484 4.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776  298 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASg 376
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053776  377 gGTADRCIRFWNTLTAQPLQCIDTGSQVCNLAWSKHTNELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 454
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 41053776  455 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 484
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
WD40 pfam00400
WD domain, G-beta repeat;
436-473 9.64e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41053776   436 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 473
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 230-282 4.42e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 4.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 41053776   230 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDATAGKKLFALEGHTARVGALAWN 282
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 349-388 1.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053776    349 PMQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWN 388
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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