NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|440462820|gb|AGC08282|]
View 

LRR-7061, partial [Anopheles gambiae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
13-157 5.74e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  13 NKQWFKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDrDVFSHVVGLEVLDLSSMKLRTLPMGIfDNL 92
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEEL-GNL 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 440462820  93 YDLELLDLGENELANglTNGVFRNLYSLKTLSLDNNHLKTLDTVLfDDLKNLRTIDLSGNELSSL 157
Cdd:COG4886  182 TNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL 243
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-157 5.74e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  13 NKQWFKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDrDVFSHVVGLEVLDLSSMKLRTLPMGIfDNL 92
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEEL-GNL 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 440462820  93 YDLELLDLGENELANglTNGVFRNLYSLKTLSLDNNHLKTLDTVLfDDLKNLRTIDLSGNELSSL 157
Cdd:COG4886  182 TNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL 243
LRR_8 pfam13855
Leucine rich repeat;
95-154 3.84e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.84e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820   95 LELLDLGENELaNGLTNGVFRNLYSLKTLSLDNNHLKTLDTVLFDDLKNLRTIDLSGNEL 154
Cdd:pfam13855   3 LRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-161 2.89e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  21 SNLQTLVLTRNGLTQFEKGIFDALDGLDalyLSGNPVGELDRDVFShvvGLEVLDLSSMKLRTLPmgifDNLYD-LELLD 99
Cdd:PRK15370 220 GNIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPS---ALQSLDLFHNKISCLP----ENLPEeLRYLS 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 440462820 100 LGEN-------ELANGLTN-GVFRNLYS---------LKTLSLDNNHLKTLDTVLFDDLKNLrtiDLSGNELSSLDPQL 161
Cdd:PRK15370 290 VYDNsirtlpaHLPSGITHlNVQSNSLTalpetlppgLKTLEAGENALTSLPASLPPELQVL---DVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-158 1.90e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  22 NLQTLVLTRNGLTQFEKgiFDALDGLDALYLSGNPVGELDRdvFSHVVGLEVLDLSSMKLRTLpmGIFDNLYDLELLDLG 101
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 440462820 102 ENELANGLT-----NGVFRNLYSLKTLSLDNNHLKTLDTvlFDDLKNLRTIDLSGNELSSLD 158
Cdd:cd21340   99 NQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE 158
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-157 5.74e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  13 NKQWFKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDrDVFSHVVGLEVLDLSSMKLRTLPMGIfDNL 92
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEEL-GNL 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 440462820  93 YDLELLDLGENELANglTNGVFRNLYSLKTLSLDNNHLKTLDTVLfDDLKNLRTIDLSGNELSSL 157
Cdd:COG4886  182 TNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-157 6.50e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 6.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  17 FKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDrDVFSHVVGLEVLDLSSMKLRTLPMGIfDNLYDLE 96
Cdd:COG4886  155 LGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLE 231

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 440462820  97 LLDLGENELAnglTNGVFRNLYSLKTLSLDNNHLKTLDTVLfdDLKNLRTIDLSGNELSSL 157
Cdd:COG4886  232 TLDLSNNQLT---DLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-159 2.02e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  16 WFKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDrDVFSHVVGLEVLDLSSMKLRTLPMGIFdNLYDL 95
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLG-NLTNL 207

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 440462820  96 ELLDLGENELANglTNGVFRNLYSLKTLSLDNNHLKTLDTvlFDDLKNLRTIDLSGNELSSLDP 159
Cdd:COG4886  208 EELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-161 2.62e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  17 FKDLSNLQTLVLTRNGLtqfekgiFDALDGLDALYLSGNPVGELDRDvFSHVVGLEVLDLSSMKLRTLPMGIFdNLYDLE 96
Cdd:COG4886   92 LGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLK 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 440462820  97 LLDLGENELANglTNGVFRNLYSLKTLSLDNNHLKTLDTVLFDdLKNLRTIDLSGNELSSLDPQL 161
Cdd:COG4886  163 SLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPL 224
LRR_8 pfam13855
Leucine rich repeat;
95-154 3.84e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.84e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820   95 LELLDLGENELaNGLTNGVFRNLYSLKTLSLDNNHLKTLDTVLFDDLKNLRTIDLSGNEL 154
Cdd:pfam13855   3 LRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-161 1.68e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  16 WFKDLSNLQTLVLTRNGLTQFEKGIFDaLDGLDALYLSGNPVGELDRDvFSHVVGLEVLDLSSMKLRTLPmgIFDNLYDL 95
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 440462820  96 ELLDLGENELANGLTNGvfrNLYSLKTLSLDNNHLKTLDTVLFDDLKNLRTIDLSGNELSSLDPQL 161
Cdd:COG4886  253 EELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR_8 pfam13855
Leucine rich repeat;
119-163 2.35e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 440462820  119 SLKTLSLDNNHLKTLDTVLFDDLKNLRTIDLSGNELSSLDPQLFH 163
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
LRR_8 pfam13855
Leucine rich repeat;
1-57 1.69e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 440462820    1 LAIVNNaKLGGLNKQWFKDLSNLQTLVLTRNGLTQFEKGIFDALDGLDALYLSGNPV 57
Cdd:pfam13855   6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-161 2.89e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  21 SNLQTLVLTRNGLTQFEKGIFDALDGLDalyLSGNPVGELDRDVFShvvGLEVLDLSSMKLRTLPmgifDNLYD-LELLD 99
Cdd:PRK15370 220 GNIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPS---ALQSLDLFHNKISCLP----ENLPEeLRYLS 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 440462820 100 LGEN-------ELANGLTN-GVFRNLYS---------LKTLSLDNNHLKTLDTVLFDDLKNLrtiDLSGNELSSLDPQL 161
Cdd:PRK15370 290 VYDNsirtlpaHLPSGITHlNVQSNSLTalpetlppgLKTLEAGENALTSLPASLPPELQVL---DVSKNQITVLPETL 365
LRR_8 pfam13855
Leucine rich repeat;
21-78 7.77e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 7.77e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 440462820   21 SNLQTLVLTRNGLTQFEKGIFDALDGLDALYLSGNPVGELDRDVFSHVVGLEVLDLSS 78
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
46-105 3.93e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 3.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820   46 GLDALYLSGNPVGELDRDVFSHVVGLEVLDLSSMKLRTLPMGIFDNLYDLELLDLGENEL 105
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-158 1.90e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  22 NLQTLVLTRNGLTQFEKgiFDALDGLDALYLSGNPVGELDRdvFSHVVGLEVLDLSSMKLRTLpmGIFDNLYDLELLDLG 101
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 440462820 102 ENELANGLT-----NGVFRNLYSLKTLSLDNNHLKTLDTvlFDDLKNLRTIDLSGNELSSLD 158
Cdd:cd21340   99 NQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE 158
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 21-161 2.03e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  21 SNLQTLVLTRNGLTQFE----KGIFDALDGLDALYLSGNPVGE-----LDRDvFSHVVGLEVLDLSSMKLRTLPM----G 87
Cdd:cd00116  137 PALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVLDLNNNGLTDEGAsalaE 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  88 IFDNLYDLELLDLGENELANG----LTNGVFRNLYSLKTLSLDNNHL-----KTLDTVLfDDLKNLRTIDLSGNELSSLD 158
Cdd:cd00116  216 TLASLKSLEVLNLGDNNLTDAgaaaLASALLSPNISLLTLSLSCNDItddgaKDLAEVL-AEKESLLELDLRGNKFGEEG 294


                 ...
gi 440462820 159 PQL 161
Cdd:cd00116  295 AQL 297
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-160 3.97e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440462820  65 FSHVVGLevlDLSSMKLRTLPMGIFDNLYDLELLDLGENELANGLTNGVFRNLYSLKTLSLDNNHLKtlDTVLFDDLKNL 144
Cdd:PLN00113  68 SSRVVSI---DLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGSIPNL 142

                         90
                 ....*....|....*.
gi 440462820 145 RTIDLSGNELSSLDPQ 160
Cdd:PLN00113 143 ETLDLSNNMLSGEIPN 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH