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Conserved domains on  [gi|441071207|gb|AGC28619|]
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LRR-7060, partial [Anopheles gambiae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13598162)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
100-153 1.39e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 441071207  100 TNLRRINFGGNRIDVVEEYTFEGLANLSVIRLSRNKIPVLPRKLFAGLSSLTSL 153
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR_8 super family cl38440
Leucine rich repeat;
52-112 6.86e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 33.27  E-value: 6.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 441071207   52 QKVDTLVMRRVDVQRVDADTFTKAVALKSLQMHRNRIPKLFNGMFRNATNLRRINFGGNRI 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
100-153 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 441071207  100 TNLRRINFGGNRIDVVEEYTFEGLANLSVIRLSRNKIPVLPRKLFAGLSSLTSL 153
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-153 1.07e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441071207  70 DTFTKAVALKSLQMHRNRIPKLFNGmFRNATNLRRINFGGNRIDVVEEyTFEGLANLSVIRLSRNKIPVLPRKLfAGLSS 149
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTN 183


                 ....
gi 441071207 150 LTSL 153
Cdd:COG4886  184 LKEL 187
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-153 1.14e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441071207  78 LKSLQMHRNRIPKLFNgmFRNATNLRRINFGGNRIDVVEEytFEGLANLSVIRLSRNKIP------VLPRKLFAGLSSLT 151
Cdd:cd21340   48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPpgekltFDPRSLAALSNSLR 123


                 ..
gi 441071207 152 SL 153
Cdd:cd21340  124 VL 125
LRR_8 pfam13855
Leucine rich repeat;
52-112 6.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 33.27  E-value: 6.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 441071207   52 QKVDTLVMRRVDVQRVDADTFTKAVALKSLQMHRNRIPKLFNGMFRNATNLRRINFGGNRI 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
100-153 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 441071207  100 TNLRRINFGGNRIDVVEEYTFEGLANLSVIRLSRNKIPVLPRKLFAGLSSLTSL 153
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR_8 pfam13855
Leucine rich repeat;
78-136 4.28e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 441071207   78 LKSLQMHRNRIPKLFNGMFRNATNLRRINFGGNRIDVVEEYTFEGLANLSVIRLSRNKI 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-153 1.07e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441071207  70 DTFTKAVALKSLQMHRNRIPKLFNGmFRNATNLRRINFGGNRIDVVEEyTFEGLANLSVIRLSRNKIPVLPRKLfAGLSS 149
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTN 183


                 ....
gi 441071207 150 LTSL 153
Cdd:COG4886  184 LKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-153 1.69e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 441071207  78 LKSLQMHRNRIPKLfNGMFRNATNLRRINFGGNRIDVVEEyTFEGLANLSVIRLSRNKIPVLPRklFAGLSSLTSL 153
Cdd:COG4886  184 LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-153 1.89e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.89e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 441071207  78 LKSLQMHRNRIPKLFNGmFRNATNLRRINFGGNRIDVVEEyTFEGLANLSVIRLSRNKIPVLPRKLfAGLSSLTSL 153
Cdd:COG4886  138 LKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEEL 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-153 1.14e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441071207  78 LKSLQMHRNRIPKLFNgmFRNATNLRRINFGGNRIDVVEEytFEGLANLSVIRLSRNKIP------VLPRKLFAGLSSLT 151
Cdd:cd21340   48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPpgekltFDPRSLAALSNSLR 123


                 ..
gi 441071207 152 SL 153
Cdd:cd21340  124 VL 125
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-154 3.09e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 36.84  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441071207  70 DTFTKAVALKSLQMHRNRIPKLFNgmFRNATNLRRINFGGNRIDVVEEytFEGLANLSVIRLSRNKIPVLPRKLFAGLSS 149
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLG 297


                 ....*
gi 441071207 150 LTSLL 154
Cdd:COG4886  298 LNSLL 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-153 3.21e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 36.84  E-value: 3.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 441071207  78 LKSLQMHRNRIPKLFNGmFRNATNLRRINFGGNRIDVVEEytFEGLANLSVIRLSRNKIPVLPrkLFAGLSSLTSL 153
Cdd:COG4886  207 LEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTL 277
LRR_8 pfam13855
Leucine rich repeat;
52-112 6.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 33.27  E-value: 6.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 441071207   52 QKVDTLVMRRVDVQRVDADTFTKAVALKSLQMHRNRIPKLFNGMFRNATNLRRINFGGNRI 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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