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Conserved domains on  [gi|443685712|gb|ELT89228|]
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hypothetical protein CAPTEDRAFT_73423, partial [Capitella teleta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWD_DHX57 cd23825
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ...
 117-298 3.92e-49

RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.


:

Pssm-ID: 467661  Cd Length: 115  Bit Score: 159.28  E-value: 3.92e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 117 DVQEQREEEKMALESIYAEAFSERIPNKVWSLNLQLTHLteistggaekksstdlkqkqkngplckffkrgncrfgarch 196
Cdd:cd23825    2 ELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL----------------------------------------- 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 197 qshdlpiepslnlveqsvpkledkseeYPYELEIRFPGSHKYPFQVPVIAFSSRNSQLPSHVCLRITERLLTEAQELCES 276
Cdd:cd23825   41 ---------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALELAED 93

                        170       180
                 ....*....|....*....|..
gi 443685712 277 HAPIVFSLVSVLEDEIEMLKCF 298
Cdd:cd23825   94 GEPVVFSLVSLLEDEEEILELL 115
UBA_DHX57 cd14317
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ...
 59-96 2.14e-14

UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.


:

Pssm-ID: 270502  Cd Length: 38  Bit Score: 66.18  E-value: 2.14e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 443685712  59 ISYDTLDLLCRYGFDRSYCETALDENDGDIGYALEMLL 96
Cdd:cd14317    1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
ZnF_C3H1 smart00356
zinc finger;
179-201 1.91e-06

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.77  E-value: 1.91e-06
                           10        20
                   ....*....|....*....|...
gi 443685712   179 PLCKFFKRGNCRFGARCHQSHDL 201
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
RWD_DHX57 cd23825
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ...
 117-298 3.92e-49

RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.


Pssm-ID: 467661  Cd Length: 115  Bit Score: 159.28  E-value: 3.92e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 117 DVQEQREEEKMALESIYAEAFSERIPNKVWSLNLQLTHLteistggaekksstdlkqkqkngplckffkrgncrfgarch 196
Cdd:cd23825    2 ELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL----------------------------------------- 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 197 qshdlpiepslnlveqsvpkledkseeYPYELEIRFPGSHKYPFQVPVIAFSSRNSQLPSHVCLRITERLLTEAQELCES 276
Cdd:cd23825   41 ---------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALELAED 93

                        170       180
                 ....*....|....*....|..
gi 443685712 277 HAPIVFSLVSVLEDEIEMLKCF 298
Cdd:cd23825   94 GEPVVFSLVSLLEDEEEILELL 115
UBA_DHX57 cd14317
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ...
 59-96 2.14e-14

UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.


Pssm-ID: 270502  Cd Length: 38  Bit Score: 66.18  E-value: 2.14e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 443685712  59 ISYDTLDLLCRYGFDRSYCETALDENDGDIGYALEMLL 96
Cdd:cd14317    1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
ZnF_C3H1 smart00356
zinc finger;
179-201 1.91e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.77  E-value: 1.91e-06
                           10        20
                   ....*....|....*....|...
gi 443685712   179 PLCKFFKRGNCRFGARCHQSHDL 201
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 198-292 1.57e-05

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 43.47  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712  198 SHDLPIEPSLNLVEQSVPKLEDKSEEYPYELEIRFPgsHKYPFQVPVIAFSSrNSQLPSHVCLRITERLLTEAQELCESh 277
Cdd:pfam05773  22 SDSPYESLEIEIKLSLDSDESDSSHLPPLVLKFTLP--EDYPDEPPKISLSS-PWNLSDEQVLSLLEELEELAEENLGE- 97

                          90
                  ....*....|....*
gi 443685712  278 aPIVFSLVSVLEDEI 292
Cdd:pfam05773  98 -VMIFELIEWLQENL 111
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 181-199 1.80e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.78  E-value: 1.80e-04
                          10
                  ....*....|....*....
gi 443685712  181 CKFFKRGNCRFGARCHQSH 199
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Name Accession Description Interval E-value
RWD_DHX57 cd23825
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ...
 117-298 3.92e-49

RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.


Pssm-ID: 467661  Cd Length: 115  Bit Score: 159.28  E-value: 3.92e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 117 DVQEQREEEKMALESIYAEAFSERIPNKVWSLNLQLTHLteistggaekksstdlkqkqkngplckffkrgncrfgarch 196
Cdd:cd23825    2 ELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL----------------------------------------- 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 197 qshdlpiepslnlveqsvpkledkseeYPYELEIRFPGSHKYPFQVPVIAFSSRNSQLPSHVCLRITERLLTEAQELCES 276
Cdd:cd23825   41 ---------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALELAED 93

                        170       180
                 ....*....|....*....|..
gi 443685712 277 HAPIVFSLVSVLEDEIEMLKCF 298
Cdd:cd23825   94 GEPVVFSLVSLLEDEEEILELL 115
UBA_DHX57 cd14317
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ...
 59-96 2.14e-14

UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.


Pssm-ID: 270502  Cd Length: 38  Bit Score: 66.18  E-value: 2.14e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 443685712  59 ISYDTLDLLCRYGFDRSYCETALDENDGDIGYALEMLL 96
Cdd:cd14317    1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
ZnF_C3H1 smart00356
zinc finger;
179-201 1.91e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.77  E-value: 1.91e-06
                           10        20
                   ....*....|....*....|...
gi 443685712   179 PLCKFFKRGNCRFGARCHQSHDL 201
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 198-292 1.57e-05

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 43.47  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712  198 SHDLPIEPSLNLVEQSVPKLEDKSEEYPYELEIRFPgsHKYPFQVPVIAFSSrNSQLPSHVCLRITERLLTEAQELCESh 277
Cdd:pfam05773  22 SDSPYESLEIEIKLSLDSDESDSSHLPPLVLKFTLP--EDYPDEPPKISLSS-PWNLSDEQVLSLLEELEELAEENLGE- 97

                          90
                  ....*....|....*
gi 443685712  278 aPIVFSLVSVLEDEI 292
Cdd:pfam05773  98 -VMIFELIEWLQENL 111
RWD_YLR419W-like cd23827
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related ...
 216-295 2.08e-05

RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; YLR419W (EC 3.6.4.13) may act as an ATP-binding RNA helicase. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467662  Cd Length: 104  Bit Score: 42.62  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 216 KLEDKSEEyPYELEIRFPGSHKYPFQVPVIAFSSrNSQLPSHVCLRITERLLTEAQELCeSHAPIVFSLVSVLEDEIEML 295
Cdd:cd23827   27 TLNSPTKT-KPSLKLKFYKSSSYPNSLPGIFISS-SDKLPAYIKLAIIRQLLQYARDNL-LGDPMIFSIVEWLEENIEEI 103
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 181-199 1.80e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.78  E-value: 1.80e-04
                          10
                  ....*....|....*....
gi 443685712  181 CKFFKRGNCRFGARCHQSH 199
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
179-200 3.91e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.17  E-value: 3.91e-04
                          10        20
                  ....*....|....*....|...
gi 443685712  179 PLCKFFKR-GNCRFGARCHQSHD 200
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDRCKFAHG 26
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 179-200 4.12e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.80  E-value: 4.12e-04
                          10        20
                  ....*....|....*....|..
gi 443685712  179 PLCKFFKRGNCRFGARCHQSHD 200
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSHD 22
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 119-293 2.74e-03

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 36.81  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 119 QEQREEEKMALESIYAEAFseripnkvwslnlqlthlteistggaekkssTDLKQKQKNGPLCKFfkrgncrfgarchqs 198
Cdd:cd23823    1 EEEQEEELEALQSIYGDDF-------------------------------EDLSSKKAVWSPPEF--------------- 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443685712 199 hDLPIEPSLNLVEQSVPKLEdkseeypyeLEIRFPgsHKYPFQVPVIAFSSRNSQLPSHVcLRITERLLTEAQELCESha 278
Cdd:cd23823   35 -RIRLRPQEGESEENHVSVD---------LHVKFP--PTYPDVPPEIELENVKGLSDEQL-EELLKELEELAKELLGE-- 99

                        170
                 ....*....|....*
gi 443685712 279 PIVFSLVSVLEDEIE 293
Cdd:cd23823  100 EMIFELAEAVQEFLE 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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