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Conserved domains on  [gi|45545431|ref|NP_076421|]
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protein delta homolog 2 isoform a precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10041892)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Homo sapiens Notch homolog 2 N-terminal-like proteins and protein delta homologs

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 174-210 2.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.92e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 174 NVDDCLMR-PCANGATCLDGINRFSCLCPEGFAGRFCT 210
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 89-129 5.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 5.12e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 45545431  89 DKDEhiCTTQSPCQNGGQCMyDGGGEYHCVCLPGFHGRDCE 129
Cdd:cd00054   1 DIDE--CASGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 212-248 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.30e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 212 NLDDCASR-PCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 174-210 2.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.92e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 174 NVDDCLMR-PCANGATCLDGINRFSCLCPEGFAGRFCT 210
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 89-129 5.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 5.12e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 45545431  89 DKDEhiCTTQSPCQNGGQCMyDGGGEYHCVCLPGFHGRDCE 129
Cdd:cd00054   1 DIDE--CASGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 212-248 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.30e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 212 NLDDCASR-PCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
174-210 4.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 4.51e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 45545431    174 NVDDCLMR-PCANGATCLDGINRFSCLCPEGF-AGRFCT 210
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
89-129 1.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 45545431     89 DKDEhiCTTQSPCQNGGQCmYDGGGEYHCVCLPGFH-GRDCE 129
Cdd:smart00179   1 DIDE--CASGNPCQNGGTC-VNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 178-208 4.16e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 4.16e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 45545431   178 CLMRPCANGATCLDGINRFSCLCPEGFAGRF 208
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
212-248 6.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.14  E-value: 6.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 45545431    212 NLDDCASR-PCQRGARCRDRVHDFDCLCPSGY-GGKTCE 248
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 174-210 2.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.92e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 174 NVDDCLMR-PCANGATCLDGINRFSCLCPEGFAGRFCT 210
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 89-129 5.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 5.12e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 45545431  89 DKDEhiCTTQSPCQNGGQCMyDGGGEYHCVCLPGFHGRDCE 129
Cdd:cd00054   1 DIDE--CASGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 212-248 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.30e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 45545431 212 NLDDCASR-PCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
174-210 4.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 4.51e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 45545431    174 NVDDCLMR-PCANGATCLDGINRFSCLCPEGF-AGRFCT 210
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
89-129 1.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 45545431     89 DKDEhiCTTQSPCQNGGQCmYDGGGEYHCVCLPGFH-GRDCE 129
Cdd:smart00179   1 DIDE--CASGNPCQNGGTC-VNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 178-208 4.16e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 4.16e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 45545431   178 CLMRPCANGATCLDGINRFSCLCPEGFAGRF 208
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
212-248 6.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.14  E-value: 6.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 45545431    212 NLDDCASR-PCQRGARCRDRVHDFDCLCPSGY-GGKTCE 248
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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