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Conserved domains on  [gi|4558196]
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Chain A, YCAC GENE PRODUCT

Protein Classification

hydrolase( domain architecture ID 10099061)

putative YcaC-like hydrolase with unknown specificity

CATH:  3.40.50.850
Gene Ontology:  GO:0016787
PubMed:  9782055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C_hydro_YcaC super family cl49446
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 4-204 3.08e-174

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


The actual alignment was detected with superfamily member NF041461:

Pssm-ID: 469349  Cd Length: 201  Bit Score: 475.66  E-value: 3.08e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     4 PYVRLDKNDAAVLLVDHQAGLLSLVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSAETGPNGPLVPELKAQFPDAPYIA 83
Cdd:NF041461   1 PYKRLDKDDAAVLLVDHQTGLLSLVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196    84 RPGNINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLM 163
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 4558196   164 TWFGVACELHRDWRNDIAGLATLFSNHIPDYRNLMTSYDTL 204
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
 
Name Accession Description Interval E-value
C_hydro_YcaC NF041461
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 4-204 3.08e-174

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


Pssm-ID: 469349  Cd Length: 201  Bit Score: 475.66  E-value: 3.08e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     4 PYVRLDKNDAAVLLVDHQAGLLSLVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSAETGPNGPLVPELKAQFPDAPYIA 83
Cdd:NF041461   1 PYKRLDKDDAAVLLVDHQTGLLSLVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196    84 RPGNINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLM 163
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 4558196   164 TWFGVACELHRDWRNDIAGLATLFSNHIPDYRNLMTSYDTL 204
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 14-174 6.84e-71

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 212.45  E-value: 6.84e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLSLVRDiePDKFKNNVLALGDLAKYFNLPTILTTSAEtGPNGPLVPELKAQFPDAPYIARPGnINAWDN 93
Cdd:cd01012   1 ALLLVDVQEKLAPAIKS--FDELINNTVKLAKAAKLLDVPVILTEQYP-KGLGPTVPELREVFPDAPVIEKTS-FSCWED 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   94 EDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLMTWFGVACELH 173
Cdd:cd01012  77 EAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFELQ 156


                .
gi 4558196  174 R 174
Cdd:cd01012 157 R 157
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 14-163 7.73e-31

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 110.76  E-value: 7.73e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLS--LVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSAET-------------------GPNGPLVPEL 72
Cdd:COG1335   1 ALLVIDVQNDFVPpgALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPpdgsefaefdlwpphcvpgTPGAELVPEL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   73 KAQfPDAPYIARPGNiNAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAW 152
Cdd:COG1335  81 APL-PGDPVVDKTRY-SAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAAL 158

                       170
                ....*....|.
gi 4558196  153 DRMSQAGAQLM 163
Cdd:COG1335 159 ARLRAAGATVV 169
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 13-165 3.14e-22

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 88.61  E-value: 3.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     13 AAVLLVDHQAGLLSLVRDIEPD--KFKNNVLALGDLAKYFNLPTILTT----------------SAETGPNGP---LVPE 71
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGiaAILENINRLLKAARKAGIPVIFTRqvpepddadfalkdrpSPAFPPGTTgaeLVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     72 LKAQFPDAPYIARPgnINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSA 151
Cdd:pfam00857  81 LAPLPGDLVVDKTR--FSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158

                         170
                  ....*....|....
gi 4558196    152 WDRMSQAGAQLMTW 165
Cdd:pfam00857 159 LERLAQRGAEVTTT 172
PLN02621 PLN02621
nicotinamidase
 9-145 3.90e-09

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 54.02  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     9 DKNDAAVLLVDHQAGLLSLVRDIEPdkfknNVLALGDLAKYFNLPTILTTSAETGP----------NGPLV------PEL 72
Cdd:PLN02621  17 DPKQAALLVIDMQNYFSSMAEPILP-----ALLTTIDLCRRASIPVFFTRHSHKSPsdygmlgewwDGDLIldgtteAEL 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4558196    73 kaqFPDAPYIARPGNI------NAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNE 145
Cdd:PLN02621  92 ---MPEIGRVTGPDEVvekstySAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE 167
 
Name Accession Description Interval E-value
C_hydro_YcaC NF041461
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 4-204 3.08e-174

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


Pssm-ID: 469349  Cd Length: 201  Bit Score: 475.66  E-value: 3.08e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     4 PYVRLDKNDAAVLLVDHQAGLLSLVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSAETGPNGPLVPELKAQFPDAPYIA 83
Cdd:NF041461   1 PYKRLDKDDAAVLLVDHQTGLLSLVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196    84 RPGNINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLM 163
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 4558196   164 TWFGVACELHRDWRNDIAGLATLFSNHIPDYRNLMTSYDTL 204
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 14-174 6.84e-71

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 212.45  E-value: 6.84e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLSLVRDiePDKFKNNVLALGDLAKYFNLPTILTTSAEtGPNGPLVPELKAQFPDAPYIARPGnINAWDN 93
Cdd:cd01012   1 ALLLVDVQEKLAPAIKS--FDELINNTVKLAKAAKLLDVPVILTEQYP-KGLGPTVPELREVFPDAPVIEKTS-FSCWED 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   94 EDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWDRMSQAGAQLMTWFGVACELH 173
Cdd:cd01012  77 EAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFELQ 156


                .
gi 4558196  174 R 174
Cdd:cd01012 157 R 157
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 14-163 7.73e-31

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 110.76  E-value: 7.73e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLS--LVRDIEPDKFKNNVLALGDLAKYFNLPTILTTSAET-------------------GPNGPLVPEL 72
Cdd:COG1335   1 ALLVIDVQNDFVPpgALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPpdgsefaefdlwpphcvpgTPGAELVPEL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   73 KAQfPDAPYIARPGNiNAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAW 152
Cdd:COG1335  81 APL-PGDPVVDKTRY-SAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAAL 158

                       170
                ....*....|.
gi 4558196  153 DRMSQAGAQLM 163
Cdd:COG1335 159 ARLRAAGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 14-155 4.81e-29

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 106.20  E-value: 4.81e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLSLVRDIEP--DKFKNNVLALGDLAKYFNLPTILTT------------------SAETGPNGPLVPELK 73
Cdd:cd00431   1 ALLVVDMQNDFVPGGGLLLPgaDELVPNINRLLAAARAAGIPVIFTRdwhppddpefaellwpphCVKGTEGAELVPELA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   74 AQfPDAPYIARpGNINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSAWD 153
Cdd:cd00431  81 PL-PDDLVIEK-TRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHEAALE 158


                ..
gi 4558196  154 RM 155
Cdd:cd00431 159 RL 160
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 13-165 3.14e-22

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 88.61  E-value: 3.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     13 AAVLLVDHQAGLLSLVRDIEPD--KFKNNVLALGDLAKYFNLPTILTT----------------SAETGPNGP---LVPE 71
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGiaAILENINRLLKAARKAGIPVIFTRqvpepddadfalkdrpSPAFPPGTTgaeLVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     72 LKAQFPDAPYIARPgnINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSA 151
Cdd:pfam00857  81 LAPLPGDLVVDKTR--FSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158

                         170
                  ....*....|....
gi 4558196    152 WDRMSQAGAQLMTW 165
Cdd:pfam00857 159 LERLAQRGAEVTTT 172
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 14-143 1.39e-10

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 57.22  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   14 AVLLVDHQAGLLSLVRDIE-PDKFKNNVLALGDLAKYFNLPTI--------LTTSAETGPNGPLVPELKAQfPDAPYIAR 84
Cdd:cd01014   1 ALLVIDVQNGYFDGGLPPLnNEAALENIAALIAAARAAGIPVIhvrhiddeGGSFAPGSEGWEIHPELAPL-EGETVIEK 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4558196   85 PGNiNAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTF 143
Cdd:cd01014  80 TVP-NAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATF 137
PLN02621 PLN02621
nicotinamidase
 9-145 3.90e-09

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 54.02  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196     9 DKNDAAVLLVDHQAGLLSLVRDIEPdkfknNVLALGDLAKYFNLPTILTTSAETGP----------NGPLV------PEL 72
Cdd:PLN02621  17 DPKQAALLVIDMQNYFSSMAEPILP-----ALLTTIDLCRRASIPVFFTRHSHKSPsdygmlgewwDGDLIldgtteAEL 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4558196    73 kaqFPDAPYIARPGNI------NAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNE 145
Cdd:PLN02621  92 ---MPEIGRVTGPDEVvekstySAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE 167
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 73-163 6.43e-09

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 53.42  E-value: 6.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   73 KAQFPD-APYIARPGNINAwDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHSA 151
Cdd:cd01011 106 KGTNPDiDSYSAFFDNDRR-SSTGLAEYLRERGIDRVDVVGLATDYCVKATALDALKAGFEVRVLEDACRAVDPETIERA 184

                        90
                ....*....|..
gi 4558196  152 WDRMSQAGAQLM 163
Cdd:cd01011 185 IEEMKEAGVVLV 196
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 101-164 7.82e-07

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 47.75  E-value: 7.82e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4558196   101 KATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEitrhSAWDRMSQ----AGAQLMT 164
Cdd:PTZ00331 142 KAHGVRRVFICGLAFDFCVLFTALDAVKLGFKVVVLEDATRAVDP----DAISKQRAelleAGVILLT 205
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
101-164 1.48e-05

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 44.21  E-value: 1.48e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4558196   101 KATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASGTFNEITRHS--AWDRMSQAGAQLMT 164
Cdd:PRK11609 138 REHGITELIVMGLATDYCVKFTVLDALALGYQVNVITDGCRGVNLQPQDSahAFMEMSAAGATLYT 203
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
63-145 9.87e-05

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 41.76  E-value: 9.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4558196   63 GPNG-PLVPELkaqfpdAPyiaRPGNI-------NAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVF 134
Cdd:COG1535  91 GPEGqEIVDEL------AP---APGDTvltkwrySAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPF 161

                        90
                ....*....|.
gi 4558196  135 VVTDASGTFNE 145
Cdd:COG1535 162 VVADAVADFSR 172
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 101-141 2.31e-03

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 37.38  E-value: 2.31e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 4558196  101 KATGKKQLIIAGVVTEVCVAFPALSAIEEGFDVFVVTDASG 141
Cdd:cd01015 110 TARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVRECVG 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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