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Conserved domains on  [gi|459654252|gb|AGG78988|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Drosophila melanogaster]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-165 1.95e-38

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.41  E-value: 1.95e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00160 172 AYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMyMIMTFFSIFGLFLIS 160
Cdd:MTH00160 252 FLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLIL-NFLSFISLFGLILSS 330


                 ....*
gi 459654252 161 LFYFM 165
Cdd:MTH00160 331 LLFLL 335
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-165 1.95e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.41  E-value: 1.95e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00160 172 AYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMyMIMTFFSIFGLFLIS 160
Cdd:MTH00160 252 FLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLIL-NFLSFISLFGLILSS 330


                 ....*
gi 459654252 161 LFYFM 165
Cdd:MTH00160 331 LLFLL 335
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 63-123 1.40e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 43.95  E-value: 1.40e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459654252  63 FTLFMnfLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFM 123
Cdd:COG1007  371 MTIFL--LSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYF 429
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 112-160 3.78e-05

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 39.55  E-value: 3.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 459654252  112 FFYLRICYSAFM-MNYFENNWIMKMNMNSI-NYNMYMIMTFFSIFGLFLIS 160
Cdd:pfam06444   1 FFYLRLSYSTTLtLFPNTNNSKMKWRFNSTkNTLLLPTLTTLSILLLPLTP 51
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-163 6.99e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 38.78  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252    1 AFSSINHLGWMLSSLMISESI--------WLIYFFFYSFLSFVLTFMFNI--FKLFHLNQLFSWFVNSKILKFTLFMNFL 70
Cdd:TIGR01770 298 AYSSISHVGYILIGLLAGTLEgikavlfyIFIYALMSLGAFGVLSLLRSYkdEWIEYISDFAGLFKTNPILAILILIFMF 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   71 SLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNyfENNWIMKMNMNSINYNMYMIMTF 150
Cdd:TIGR01770 378 SLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYFDK--PERRIPSNPQSKAQSLLLSISAL 455

                         170
                  ....*....|...
gi 459654252  151 FSIFGLFLISLFY 163
Cdd:TIGR01770 456 FILFLGLFPSLIL 468
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-165 1.95e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 133.41  E-value: 1.95e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00160 172 AYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMyMIMTFFSIFGLFLIS 160
Cdd:MTH00160 252 FLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLIL-NFLSFISLFGLILSS 330


                 ....*
gi 459654252 161 LFYFM 165
Cdd:MTH00160 331 LLFLL 335
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-120 6.46e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 84.47  E-value: 6.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00135 179 AYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTPLILLSLGGLPPLTG 258

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 459654252  81 FLPKWLVIQQLTlcNQYFML--TIMMMSTLITLFFYLRICYS 120
Cdd:MTH00135 259 FMPKWLILQELT--KQDLPLtaTLAALSALLSLYFYLRLSYA 298
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-123 3.04e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 82.56  E-value: 3.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00112 180 AFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTLMLTLLSLAGLPPLTG 259

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFM 123
Cdd:MTH00112 260 FMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTI 302
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-120 1.72e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 77.65  E-value: 1.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00070 180 AYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLTLLSLGGLPPTTG 259

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYS 120
Cdd:MTH00070 260 FIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYA 299
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-166 8.01e-16

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 73.04  E-value: 8.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00041 180 AFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFLFILSILSLGGLPPLTG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMYM----IMTFFSIFGL 156
Cdd:MTH00041 260 FLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGNITVYGvilsILSSISILGL 339

                        170
                 ....*....|
gi 459654252 157 FLISLFYFMF 166
Cdd:MTH00041 340 LLIPLFLSFL 349
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-120 1.31e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 72.57  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00105 180 AYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLILLTLLSLGGLPPLTG 259

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYS 120
Cdd:MTH00105 260 FMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYS 299
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-166 2.59e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 71.92  E-value: 2.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00200 180 AYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLGLTLLSLGGLPPLTG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMYM-IMTFFSIFGLFLI 159
Cdd:MTH00200 260 FFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSNSNLLVgLLLLLSILGLPLT 339


                 ....*..
gi 459654252 160 SLFYFMF 166
Cdd:MTH00200 340 PQLLFLF 346
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-159 3.81e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 65.46  E-value: 3.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00197 165 AYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLGGLPPLSG 244

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMYMIMTFFSIFGLFLI 159
Cdd:MTH00197 245 FFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMMLPLLMIFTMI 323
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-164 3.83e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 57.20  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMnFLSLGGLPPFLG 80
Cdd:MTH00144 173 AYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISL-LLSLGGLPPFLG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNYfennwimKMNMNSINYNMYMIMTFFSIFGLFLIS 160
Cdd:MTH00144 252 FCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSS-------KSKKSNSSKVLNSSIISLNLLGGLLFL 324


                 ....
gi 459654252 161 LFYF 164
Cdd:MTH00144 325 LLYL 328
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-124 1.89e-09

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 55.17  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLG 80
Cdd:MTH00011 176 AYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSLGGLPPFTG 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 459654252  81 FLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMM 124
Cdd:MTH00011 256 FMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYL 299
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 63-123 1.40e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 43.95  E-value: 1.40e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459654252  63 FTLFMnfLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFM 123
Cdd:COG1007  371 MTIFL--LSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYF 429
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 112-160 3.78e-05

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 39.55  E-value: 3.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 459654252  112 FFYLRICYSAFM-MNYFENNWIMKMNMNSI-NYNMYMIMTFFSIFGLFLIS 160
Cdd:pfam06444   1 FFYLRLSYSTTLtLFPNTNNSKMKWRFNSTkNTLLLPTLTTLSILLLPLTP 51
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-107 4.76e-05

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 42.30  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252    1 AFSSINHLGWMLSSLMISESIWLIYFFFYSFL---------SFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLS 71
Cdd:pfam00361 176 AYSSISHMGYMLIALGAGTIYGIQAAIFHLLThglfsaglfLCAGSVIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLS 255

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 459654252   72 LGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMST 107
Cdd:pfam00361 256 LAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 70-123 4.86e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 42.56  E-value: 4.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 459654252  70 LSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFM 123
Cdd:PRK08375 377 LSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYRAFF 430
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
63-117 1.13e-04

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 41.34  E-value: 1.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 459654252  63 FTLFMnfLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRI 117
Cdd:PRK05777 372 MTIFM--LSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRV 424
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 1-117 1.29e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 41.17  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   1 AFSSINHLGWMLSSLMIS--ESI-----WLIYFFFYSFLSFVLTFMFNIFKLFhLNQLFSWFVNSKILKFTLFMNFLSLG 73
Cdd:MTH00196 181 AYSGIGHMGFVLWGIEIGsfESIqaslvYLFIYIIMSICVFSIILALNVYKNL-IIEFSGLSRRLPILAITLALTFLSIA 259

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 459654252  74 GLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRI 117
Cdd:MTH00196 260 GIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 60-121 4.52e-04

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 39.36  E-value: 4.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459654252  60 ILKFTLFMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSA 121
Cdd:COG0651  368 LTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFGRA 429
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
66-122 6.26e-04

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 39.16  E-value: 6.26e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 459654252  66 FMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAF 122
Cdd:PRK12663 374 LILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRIFFLAY 430
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-163 6.99e-04

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 38.78  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252    1 AFSSINHLGWMLSSLMISESI--------WLIYFFFYSFLSFVLTFMFNI--FKLFHLNQLFSWFVNSKILKFTLFMNFL 70
Cdd:TIGR01770 298 AYSSISHVGYILIGLLAGTLEgikavlfyIFIYALMSLGAFGVLSLLRSYkdEWIEYISDFAGLFKTNPILAILILIFMF 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459654252   71 SLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAFMMNyfENNWIMKMNMNSINYNMYMIMTF 150
Cdd:TIGR01770 378 SLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYFDK--PERRIPSNPQSKAQSLLLSISAL 455

                         170
                  ....*....|...
gi 459654252  151 FSIFGLFLISLFY 163
Cdd:TIGR01770 456 FILFLGLFPSLIL 468
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 60-117 2.45e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 37.30  E-value: 2.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 459654252  60 ILKFTLFMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRI 117
Cdd:MTH00199 341 VIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
PRK07691 PRK07691
putative monovalent cation/H+ antiporter subunit D; Reviewed
 60-122 2.51e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 181085 [Multi-domain]  Cd Length: 496  Bit Score: 37.24  E-value: 2.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 459654252  60 ILKFTLFMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTIMMMSTLITLFFYLRICYSAF 122
Cdd:PRK07691 371 VLGWMFFIAALSLAGIPPLSGFYGKFFIVEGTFEAGFYVSGIIVLLSSLLVLYSVIKIFLKGF 433
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 61-117 2.54e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 37.53  E-value: 2.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459654252  61 LKFTLFMNFLSLGGLPPFLGFLPKWLVIQ-------QLTLCNQYFMLTIMMMSTLITLFFYLRI 117
Cdd:MTH00198 470 IAFSLAIVFLSLAGIPPLLGFLGKWFILVgsikiafSSSLSIYYLVALFAIICTCISAFYYIRI 533
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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