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Conserved domains on  [gi|47117248|sp|Q8R5A0|]
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RecName: Full=N-lysine methyltransferase SMYD2; AltName: Full=Histone methyltransferase SMYD2; AltName: Full=SET and MYND domain-containing protein 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-269 1.85e-144

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


:

Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 409.98  E-value: 1.85e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   7 GGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTvgerghhceccfarkeglskcgrckqafycdvecqkedwplh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  87 klecssmvvlgenwnPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 167 PDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 47117248 247 TEDRNDRLRDSYFFTCECRECTT 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
zf-MYND pfam01753
MYND finger;
52-90 7.96e-14

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.96e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47117248    52 CECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
TPR_10 pfam13374
Tetratricopeptide repeat;
388-422 7.65e-03

Tetratricopeptide repeat;


:

Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 34.01  E-value: 7.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47117248   388 LGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPY 422
Cdd:pfam13374   8 LANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
 
Name Accession Description Interval E-value
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-269 1.85e-144

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 409.98  E-value: 1.85e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   7 GGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTvgerghhceccfarkeglskcgrckqafycdvecqkedwplh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  87 klecssmvvlgenwnPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 167 PDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 47117248 247 TEDRNDRLRDSYFFTCECRECTT 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
zf-MYND pfam01753
MYND finger;
52-90 7.96e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.96e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47117248    52 CECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 157-240 4.74e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 45.21  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   157 HQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIfpdvALMNHSCCPNVIVTY----KGTLAEVRAVQEIHP 232
Cdd:pfam00856  31 DKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWA----RFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKP 106


                  ....*...
gi 47117248   233 GDEVFTSY 240
Cdd:pfam00856 107 GEELTIDY 114
TPR_10 pfam13374
Tetratricopeptide repeat;
388-422 7.65e-03

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 34.01  E-value: 7.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47117248   388 LGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPY 422
Cdd:pfam13374   8 LANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 195-247 9.24e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 36.16  E-value: 9.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47117248    195 GSAIFPDVALMNHSCCPNVIVTY----KGTLAEVRAVQEIHPGDEVFTSYIDLLYPT 247
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
 
Name Accession Description Interval E-value
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-269 1.85e-144

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 409.98  E-value: 1.85e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   7 GGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTvgerghhceccfarkeglskcgrckqafycdvecqkedwplh 86
Cdd:cd19202   1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  87 klecssmvvlgenwnPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEF 166
Cdd:cd19202  39 ---------------PSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLEF 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 167 PDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYP 246
Cdd:cd19202 104 PDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYP 183

                       250       260
                ....*....|....*....|...
gi 47117248 247 TEDRNDRLRDSYFFTCECRECTT 269
Cdd:cd19202 184 TEDRNDRLRDSYFFTCECQECTT 206
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 7-269 4.39e-116

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 337.86  E-value: 4.39e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   7 GGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTvgerghhceccfarkeglskcgrckqafycdvecqkedwplh 86
Cdd:cd19167   1 GQVERFCSPGKGRGLRALKPFEPGDLIFSERPYAYVLT------------------------------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  87 klecssmvvlgenwnPSETVRLTARILAKQKIHPERTpSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEF 166
Cdd:cd19167  39 ---------------PPEHVRLTGRILYKQHIRKTRT-SGKLLSVYDLESHVEKLDEEKKDGLRSDVATLHQFMSKDLQL 102

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 167 PDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYP 246
Cdd:cd19167 103 PDAAYLVELFGKVNCNGFTISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYIDLLYP 182

                       250       260
                ....*....|....*....|...
gi 47117248 247 TEDRNDRLRDSYFFTCECRECTT 269
Cdd:cd19167 183 TEERRDQLRDQYFFLCQCADCQT 205
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 7-269 1.84e-50

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 169.85  E-value: 1.84e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   7 GGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTvgerghhceccfarkeglskcgrckqafycdvecqkEDWPLH 86
Cdd:cd19203   1 SKVEKFETAEKGRGLRAVTPLKPGELVLKADPFAYTVC------------------------------------NPPDSV 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  87 KLECssmvvlgenwnpsetvrltaRILAKQKiHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQF----YSK 162
Cdd:cd19203  45 RLEG--------------------RIIFKLL-DKAPSESEKLYSFYDLQSNINKLSEDRKEGLRQLAMVLQHYlreeIQD 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 163 YLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYID 242
Cdd:cd19203 104 ASQLPPAFDIFELFAKVTCNSFTICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISYID 183

                       250       260
                ....*....|....*....|....*..
gi 47117248 243 LLYPTEDRNDRLRDSYFFTCECRECTT 269
Cdd:cd19203 184 MLMPSEERRKQLRDQYCFECDCFRCQD 210
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 8-268 1.46e-47

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 162.20  E-value: 1.46e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   8 GLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLtvgerghhceccFARKeglskcgrckqafycdvecqkedwplhk 87
Cdd:cd10526   2 GVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVV------------FGKA---------------------------- 41

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  88 lecssmvvlgenwnPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSkYLEFP 167
Cdd:cd10526  42 --------------PNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWP-YQSQQ 106

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 168 D-HSSLVVLFAQVNCNGFTIEDEE-LSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLY 245
Cdd:cd10526 107 FsMEYISHIFGVINCNGFTLSDQRgLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFLN 186

                       250       260
                ....*....|....*....|...
gi 47117248 246 PTEDRNDRLRDSYFFTCECRECT 268
Cdd:cd10526 187 TSEDRKEQLKKQYYFDCTCEHCT 209
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 176-267 4.27e-27

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 104.77  E-value: 4.27e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 176 FAQVNCNGFTIEDEElSHLGSAIFPDVALMNHSCCPNVIVTYKGTL-AEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRL 254
Cdd:cd20071  31 LVSVPSNSFSLTDGL-NEIGVGLFPLASLLNHSCDPNAVVVFDGNGtLRVRALRDIKAGEELTISYIDPLLPRTERRREL 109

                        90
                ....*....|...
gi 47117248 255 RDSYFFTCECREC 267
Cdd:cd20071 110 LEKYGFTCSCPRC 122
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 172-267 6.51e-23

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 96.21  E-value: 6.51e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 172 LVVLFAQVNCNGFTIED--EELSH----------LGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTS 239
Cdd:cd10536 109 LLRHLQQLQCNAHAITElqTTSSGsqvdtskqvrIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITIC 188

                        90       100       110
                ....*....|....*....|....*....|
gi 47117248 240 Y--IDLLYPTEDRNDRLRDSYFFTCECREC 267
Cdd:cd10536 189 YgpHFSRMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
52-90 7.96e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.96e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47117248    52 CECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLEC 90
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 11-267 1.18e-10

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 61.94  E-value: 1.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  11 RFCSAGKGRGLRALRPFHVGDLLFScpayacvltvgERGHHCeCCFARKEglskcgrckqafycdvecqkedwpLHKLec 90
Cdd:cd10521   5 RFIDAAKGRGLFATRDFKKGDIIFE-----------EKPLVC-AQFLWNE------------------------LHPL-- 46

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248  91 ssmVVLGENWN----PSET--VRLTARILA--KQKIHPERtpsekllAVREFESHLDKLDNEKKDLI--------QSDIA 154
Cdd:cd10521  47 ---NKLQEAWRnmhyPPETasIMLIARMIAtvKQAKDKDE-------WLKLFSQFCSATANEEEHIAhkllgkqfQGQLE 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 155 ALHQFYSKYL------EF--PDH-SSLVVL------------FAQ--VNCNGFTIEDEELSHL----------------- 194
Cdd:cd10521 117 LLRQLFTEALyeerlsQWftPEGfRSLFALvgtngqgigtssLSVwvHNCDALELPEQEREELdafidqlyvdiekesge 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248 195 -----GSAIFPDVALMNHSCCPNVIVTYKG---TLAeVRAVQEIHPGDEVFTSYIDLLYPTEDRNDR---LRDSYFFTCE 263
Cdd:cd10521 197 flnceGSGLYLLQSCCNHSCVPNAEITFPEnnfTLS-LKALRDIQEGEEICISYLDECQRERSRHSRqkiLRENYLFICN 275


                ....
gi 47117248 264 CREC 267
Cdd:cd10521 276 CPKC 279
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 202-267 5.12e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 48.82  E-value: 5.12e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47117248 202 VALMNHSCCPNVI-VTYKGTLAEVRAVQEIHPGDEVFTSYidllyptedrndrlRDSYFFT----CECREC 267
Cdd:cd10524  77 AAFINHDCRPNCKfVPTGKSTACVKVLRDIEPGEEITVYY--------------GDNYFGEnneeCECETC 133
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 157-240 4.74e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 45.21  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117248   157 HQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIfpdvALMNHSCCPNVIVTY----KGTLAEVRAVQEIHP 232
Cdd:pfam00856  31 DKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWA----RFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKP 106


                  ....*...
gi 47117248   233 GDEVFTSY 240
Cdd:pfam00856 107 GEELTIDY 114
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 205-240 3.45e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 38.77  E-value: 3.45e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 47117248 205 MNHSCCPNVIVTY----KGTLAEVRAVQEIHPGDEVFTSY 240
Cdd:cd08161  32 INHSCEPNCEFEEvyvgGKPRVFIVALRDIKAGEELTVDY 71
TPR_10 pfam13374
Tetratricopeptide repeat;
388-422 7.65e-03

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 34.01  E-value: 7.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47117248   388 LGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPY 422
Cdd:pfam13374   8 LANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
TPR_12 pfam13424
Tetratricopeptide repeat;
381-426 8.43e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.06  E-value: 8.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 47117248   381 VASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEI 426
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATT 47
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 195-247 9.24e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 36.16  E-value: 9.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47117248    195 GSAIFPDVALMNHSCCPNVIVTY----KGTLAEVRAVQEIHPGDEVFTSYIDLLYPT 247
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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