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Conserved domains on  [gi|47205277|emb|CAF94544|]
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unnamed protein product, partial [Tetraodon nigroviridis]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-352 4.62e-171

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17402:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 444  Bit Score: 490.60  E-value: 4.62e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   1 SCLAGILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDE 79
Cdd:cd17402 136 SLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFiDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSLQQ 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  80 rqlgggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGF 159
Cdd:cd17402 216 ----------------------------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGF 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 160 AAFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPV 239
Cdd:cd17402 250 AAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPV 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 240 AGVTVNYSNETSPSRSPP-APSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSGCWCVSGSSAQ-AVASPGRCP 317
Cdd:cd17402 330 AGVTVPYGNDTAPGSSLDpYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAEnATVVPGKCP 409

                       330       340       350
                ....*....|....*....|....*....|....*
gi 47205277 318 RPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17402 410 SPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
 
Name Accession Description Interval E-value
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 1-352 4.62e-171

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 490.60  E-value: 4.62e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   1 SCLAGILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDE 79
Cdd:cd17402 136 SLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFiDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSLQQ 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  80 rqlgggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGF 159
Cdd:cd17402 216 ----------------------------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGF 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 160 AAFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPV 239
Cdd:cd17402 250 AAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPV 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 240 AGVTVNYSNETSPSRSPP-APSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSGCWCVSGSSAQ-AVASPGRCP 317
Cdd:cd17402 330 AGVTVPYGNDTAPGSSLDpYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAEnATVVPGKCP 409

                       330       340       350
                ....*....|....*....|....*....|....*
gi 47205277 318 RPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17402 410 SPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 5-440 4.08e-127

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 381.55  E-value: 4.08e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277     5 GILFSTLVFGPACGFILGSVCTKVYVDavFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALderqlgg 84
Cdd:pfam03137 127 GILYAVRVLGPALGFLLGSLCLRIYVD--IGKVSITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSL------- 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277    85 GGGESEQAMlpPSLAPEGPAPGRRGSVLGSDadaglSVCEHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:pfam03137 198 PGAAKRRAK--KKKEPHSQDIADLKKTKSLK-----KLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLP 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 244
Cdd:pfam03137 271 KYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITV 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   245 NYSNeTSPSRSPPAPSCISNCNCRTASASPVCGSN-AVTYLSACFAGCTRANLSG-------CWCVSGSSAQAV---ASP 313
Cdd:pfam03137 351 PYGG-TQQLSGNLTSSCNSDCSCSTSAYSPVCGSDgGYTSPCPCGAGCSSSSGAGkstyicnCCCSCGSQDSGGngsATP 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   314 GRCPrPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIRrveaaghqgappegeinvwsicfdppclcasrTVSPERKSY 393
Cdd:pfam03137 430 GKCP-SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILR--------------------------------CVPPEDKSF 476

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 47205277   394 ALGVLFLLLRLIGFIPPPLIFGMGIDSTCLFWSTVCGERGACLLYDN 440
Cdd:pfam03137 477 ALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGRGNCWLYDN 523
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 5-471 1.44e-82

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 269.29  E-value: 1.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277     5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDerqlg 83
Cdd:TIGR00805 210 GILESGSVFGPAFGFLLGSFCLQIYVDTGSvNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLP----- 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277    84 gGGGESEQAMLPPSLAPEGPAPGRRGSVLGsdadaglsvceHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:TIGR00805 285 -KEGKRVNVDVHEAEKLEKSRGEDRKKNSG-----------ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFL 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 243
Cdd:TIGR00805 353 PKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVN 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   244 VNYSNETSPSRSPPApsCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCVSgSSAQAVASPGRC 316
Cdd:TIGR00805 433 NPSNDQPLYVENRTD--CNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGsnmvftnCSCIQ-TPGNSSAKKGLC 509

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   317 PRPgCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIRrveaaghqgappegeinvwsicfdppclcasrTVSPERKSYALG 396
Cdd:TIGR00805 510 DPP-CATSLQYFLILFIPLSFIYFITAVPGYMVLLR--------------------------------CVKSEERSLGLG 556

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47205277   397 VLFLLLRLIGFIPPPLIFGMGIDSTCLFWSTVC-GERGACLLYDNLAYRHLYVSIAIVLKSSAFLLYATTWRCLRK 471
Cdd:TIGR00805 557 LQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
 261-316 5.51e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 34.96  E-value: 5.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 47205277    261 CISNCncrTASASPVCGSNAVTYLSACFAGCTRanlsgcwCVSGSSAQaVASPGRC 316
Cdd:smart00280   2 CPEAC---PREYDPVCGSDGVTYSNECHLCKAA-------CESGKSIE-VKHDGPC 46
 
Name Accession Description Interval E-value
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 1-352 4.62e-171

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 490.60  E-value: 4.62e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   1 SCLAGILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDE 79
Cdd:cd17402 136 SLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFiDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSLQQ 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  80 rqlgggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGF 159
Cdd:cd17402 216 ----------------------------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGF 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 160 AAFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPV 239
Cdd:cd17402 250 AAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPV 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 240 AGVTVNYSNETSPSRSPP-APSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSGCWCVSGSSAQ-AVASPGRCP 317
Cdd:cd17402 330 AGVTVPYGNDTAPGSSLDpYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAEnATVVPGKCP 409

                       330       340       350
                ....*....|....*....|....*....|....*
gi 47205277 318 RPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17402 410 SPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 5-440 4.08e-127

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 381.55  E-value: 4.08e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277     5 GILFSTLVFGPACGFILGSVCTKVYVDavFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALderqlgg 84
Cdd:pfam03137 127 GILYAVRVLGPALGFLLGSLCLRIYVD--IGKVSITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSL------- 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277    85 GGGESEQAMlpPSLAPEGPAPGRRGSVLGSDadaglSVCEHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:pfam03137 198 PGAAKRRAK--KKKEPHSQDIADLKKTKSLK-----KLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLP 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 244
Cdd:pfam03137 271 KYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITV 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   245 NYSNeTSPSRSPPAPSCISNCNCRTASASPVCGSN-AVTYLSACFAGCTRANLSG-------CWCVSGSSAQAV---ASP 313
Cdd:pfam03137 351 PYGG-TQQLSGNLTSSCNSDCSCSTSAYSPVCGSDgGYTSPCPCGAGCSSSSGAGkstyicnCCCSCGSQDSGGngsATP 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   314 GRCPrPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIRrveaaghqgappegeinvwsicfdppclcasrTVSPERKSY 393
Cdd:pfam03137 430 GKCP-SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILR--------------------------------CVPPEDKSF 476

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 47205277   394 ALGVLFLLLRLIGFIPPPLIFGMGIDSTCLFWSTVCGERGACLLYDN 440
Cdd:pfam03137 477 ALGLQFLILRLLGFIPGPILFGALIDSTCLLWGKTCGGRGNCWLYDN 523
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 5-352 7.80e-88

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 276.43  E-value: 7.80e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDavFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPqalderqlgg 84
Cdd:cd17336 127 GILYAMRVLGPALGFLLGSFLLRIYVD--FSRVPLGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP---------- 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  85 gggeseqamlppslapegpapgrrgsvlgsdadaglsvcehlrviprvtrhllsnPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:cd17336 195 -------------------------------------------------------PIFILLLLAIVFESFAISGFSTFLP 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 244
Cdd:cd17336 220 KYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVTT 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 245 NYSNETspsrSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANL-------SGCWCVSGSSAQAVASPGRC- 316
Cdd:cd17336 300 PYGSSS----SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAgngtktySNCSCINSGTATSSGCPPDCs 375

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 47205277 317 PRPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17336 376 VAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 5-471 1.44e-82

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 269.29  E-value: 1.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277     5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDerqlg 83
Cdd:TIGR00805 210 GILESGSVFGPAFGFLLGSFCLQIYVDTGSvNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLP----- 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277    84 gGGGESEQAMLPPSLAPEGPAPGRRGSVLGsdadaglsvceHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:TIGR00805 285 -KEGKRVNVDVHEAEKLEKSRGEDRKKNSG-----------ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFL 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 243
Cdd:TIGR00805 353 PKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVN 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   244 VNYSNETSPSRSPPApsCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCVSgSSAQAVASPGRC 316
Cdd:TIGR00805 433 NPSNDQPLYVENRTD--CNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGsnmvftnCSCIQ-TPGNSSAKKGLC 509

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   317 PRPgCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIRrveaaghqgappegeinvwsicfdppclcasrTVSPERKSYALG 396
Cdd:TIGR00805 510 DPP-CATSLQYFLILFIPLSFIYFITAVPGYMVLLR--------------------------------CVKSEERSLGLG 556

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47205277   397 VLFLLLRLIGFIPPPLIFGMGIDSTCLFWSTVC-GERGACLLYDNLAYRHLYVSIAIVLKSSAFLLYATTWRCLRK 471
Cdd:TIGR00805 557 LQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 1-352 7.44e-73

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 238.02  E-value: 7.44e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   1 SCLAGILFSTLVFGPACGFILGSVCTKVYVDAVfdTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQalder 80
Cdd:cd17404 123 SLYLAIMYVMGALGPAAGFLLGGLLINFYVDPL--STPPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK----- 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  81 qlgggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehlrviprvtrhllsnPVFSCITLAACMEIAVVAGFA 160
Cdd:cd17404 196 -----------------------------------------------------------MTFLVVSLGYCMELAIVSGFI 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 161 AFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVA 240
Cdd:cd17404 217 TFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLA 296

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 241 GVTVNY---SNETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRA--------NLSGCWCV---SGSS 306
Cdd:cd17404 297 GITIPYttgPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVgntstgirNYTNCACLqsrSSIS 376

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 47205277 307 AQAVASPGRC---PRPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17404 377 PPTVGQGSQLqagPCSRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 5-352 5.46e-65

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 217.12  E-value: 5.46e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAVFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPqalderqlgg 84
Cdd:cd17403 130 GIFYAMAILGPAIGYVLGGFLLNLYTDIDQVDSELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP---------- 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  85 gggeseqamlppslapegpapgrrgsvlgsdadaglsvcehlrviprvtrhllsnPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:cd17403 200 -------------------------------------------------------PTFMFLNLAGASEGMLLAGFATFLP 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACyVSFLFLGCDTGPVAGVTV 244
Cdd:cd17403 225 KLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILLIYCPNAPFAGVTV 303

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 245 NYSNETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRA-------NLSGCWCV---SGSSAQAVASPG 314
Cdd:cd17403 304 PYGNSPLEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTShgddgqkVYSNCSCIqsnSSKTSTAATGKA 383

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 47205277 315 RCPRPGCQEAFLtFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17403 384 CPCETCCQKLYL-FLAVFFLLIVFTFMSSTPALSATLR 420
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
 6-352 3.53e-64

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 216.59  E-value: 3.53e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   6 ILFSTLVFGPACGFILGSVCTKVYVD-AVFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALderqLGG 84
Cdd:cd17461 141 ILFAISVFGPAFGYLLGSVVLRIFVDiGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREM----LVG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  85 GGGESEQAMLPPSLAPEGpapgRRGSVLgsdadaglsvcEHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:cd17461 217 KKPSPEGDMLRKKEDEKK----EEGSLL-----------DFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLN 281

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 244
Cdd:cd17461 282 KFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVAGVYP 361

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 245 NYSNETspsrSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANL----------SGCWCVSGSSAQAVASPG 314
Cdd:cd17461 362 KTSNSS----DGPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMdsstyrqqiySNCSCIPDLSGEKPAKTG 437

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 47205277 315 RCPRPgCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17461 438 SCPNS-CSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 5-352 7.62e-64

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 215.79  E-value: 7.62e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDA-VFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDERqlg 83
Cdd:cd17460 136 GILFAVTVLGPGFGFMLGSAMLRFYVDIdKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPKE--- 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  84 ggggESEQAMLPPSLAPEGPApGRRGSvlgSDADAGLSVCEHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:cd17460 213 ----VVELQPREKKLAKTMLK-KLKSL---SDILQNLSLLQFIKKFPRILLRTLRNPIYLLVVLAQVNLSAMVAGLATFM 284

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 243
Cdd:cd17460 285 GKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGIT 364

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 244 VNYSNETspsRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANL----------SGCWCVSGSSAQAVASP 313
Cdd:cd17460 365 HRTSSSP---GLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSVNVqaldnsvvnyTDCSCVSEGGPVGAASP 441

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 47205277 314 GRCPrPGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17460 442 GTCG-SGCSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
 5-352 2.35e-58

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 201.53  E-value: 2.35e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDERQLg 83
Cdd:cd17459 184 GCVQTIAIIGPVFGFLLGSLCAKLYVDIGFvNLDSITITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLPKSLPKDFL- 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  84 ggggeseqamlpPSLapegpapgrrgsvlgsdadaglsvcehlrviprvtRHLLSNPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:cd17459 263 ------------PSL-----------------------------------KNLLGNPVYFLYLCTSILQFNSLIGMVTYK 295

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 243
Cdd:cd17459 296 PKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDVAGLT 375

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 244 VNYSNETSPSRSPPA--PSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCV---SGSSAQAVA 311
Cdd:cd17459 376 VSYNGTKQVSYADRSlfSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGkntvfhnCSCIgipSSASGSSSA 455

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 47205277 312 SPGRCPR-PGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17459 456 ILGQCPKgNACARMFLYFLAISVISSFTLSLGGTPGYILLIR 497
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 5-352 1.90e-56

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 197.38  E-value: 1.90e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALDERqlg 83
Cdd:cd17458 180 GCLHTATIVGPLLGLLLASFCAQLYVDLGSvNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKE--- 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  84 ggGGESEqamlppslapegPAPGRRGSVLGSDAD---AGLSVCEHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFA 160
Cdd:cd17458 257 --GEENE------------TEPSKTLTVELEENKgqeTKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMI 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 161 AFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVA 240
Cdd:cd17458 323 SFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVA 402

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 241 GVTVNYS--NETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCV--SGSSAQA 309
Cdd:cd17458 403 GLTVSYEgiDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGknmvfqnCSCVaaSGFPSQN 482

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 47205277 310 VASPGRCPR-PGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17458 483 SSAVGQCDKgETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIR 526
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 5-352 3.11e-55

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 192.36  E-value: 3.11e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSAL---FMFGFPQALder 80
Cdd:cd17457 147 ACLHTIAMIGPMIGFTLGSLFAKLYVDIGFvDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIpffFLPGFFQSL--- 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  81 qlgggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehlrviprvtRHLLSNPVFSCITLAACMEIAVVAGFA 160
Cdd:cd17457 224 -----------------------------------------------------KSILTNRLYVMFVCLTLLQVSSFIGFF 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 161 AFLGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVA 240
Cdd:cd17457 251 TYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVA 330

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 241 GVTVNY--SNETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCVSGSSAQAV- 310
Cdd:cd17457 331 GITMTYdgNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGkpivfhnCSCLEVTGSQNRn 410

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 47205277 311 --ASPGRCPR-PGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17457 411 ysAHLGECPRdDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
 5-352 1.91e-51

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 181.58  E-value: 1.91e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVD-AVFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQalderqlg 83
Cdd:cd17401 136 GILFAVTVFGPAFGYLLGSVMLRLYVDiGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPR-------- 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  84 ggggeseqamlppslapegpapgrrgsvlgsdadaglsvceHLRVIPRVTRHLLSNPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:cd17401 208 -----------------------------------------FIKRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFL 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVt 243
Cdd:cd17401 247 NKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGV- 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 244 vnYSNETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-----------CWCVSGSSaqAVAS 312
Cdd:cd17401 326 --YPPSSSSSIHPQSPACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNINMSTsatskqviytnCSCVTGGS--ASAK 401

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 47205277 313 PGRCPRPgCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17401 402 TGSCPSP-CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 5-352 4.60e-51

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 180.32  E-value: 4.60e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDaVFDTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALderqlgg 84
Cdd:cd17463 130 GIGYGMSVLGPAIGYLLGGQLLNIYID-VNKGQSVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPKHL------- 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  85 gggeseqamlppslapegpaPGrrgsvlgsdadaglsvcehlrviprvtrhLLSNPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:cd17463 202 --------------------PG-----------------------------LLKNPVFMCLTISSCSEALITTGFATFLP 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 244
Cdd:cd17463 233 KFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSE 312

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 245 NYsnETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCVSGSSAQAVASPGRCP 317
Cdd:cd17463 313 TY--NGTGKIGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDkkkvyynCSCIGNFTEEFSANTTKCE 390

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 47205277 318 RPGCQEA----FLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17463 391 EGKKCETtcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
 5-352 4.44e-49

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 175.02  E-value: 4.44e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAVF-DTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPqalderqlg 83
Cdd:cd17400 140 GLVETGAIIGPIIGFLLGSLCAKVYVDIGFvNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP--------- 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  84 ggggeseqamlppslapegpapgrrgsvlgsdadaglsvcehlrviprvtrhllsnPVFSCITLAACMEIAVVAGFAAFL 163
Cdd:cd17400 211 --------------------------------------------------------PIYMLFILVSVIQFNSFVGMITYM 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 164 GKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 243
Cdd:cd17400 235 PKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLT 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 244 VNY--SNETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRANLSG-------CWCV---SGSSAQAVA 311
Cdd:cd17400 315 TSYegIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGknivfynCSCIqtsGNSSANLSL 394

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 47205277 312 SPGRCPR-PGCQEAFLTFLCVVCVCSMIGAMAQTPSVIILIR 352
Cdd:cd17400 395 CDGGCPRdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 5-332 1.47e-43

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 160.00  E-value: 1.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDAvfdTRKLDITPDDPRWIGAWWGGFLLCGALLFLSALFMFGFPQALderqlgg 84
Cdd:cd17462 130 GIFYTAAIVGPAAGYLLGGFFLNIYTEI---GRQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL------- 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  85 gggeseqamlppslapegpaPGrrgsvlgsdadaglsvcehlrviprvtrhLLSNPVFSCITLAACMEIAVVAGFAAFLG 164
Cdd:cd17462 200 --------------------PG-----------------------------LLKNPTFIFLCLAGATEATLIAGMSTFGP 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 165 KYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFlFLGCDTGPVAGVTV 244
Cdd:cd17462 231 KFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIF-SLHCPNVPMAGVTA 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 245 NYS-NETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCTRAN---------LSGCWCVSG--SSAQAVAS 312
Cdd:cd17462 310 SYRgSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYsdirngqkvYQDCSCVAGnlSVGFGEAS 389

                       330       340
                ....*....|....*....|..
gi 47205277 313 PGRCPRPgCQE--AFLTFLCVV 332
Cdd:cd17462 390 AGKCTSN-CNHmpLLLAFVFLV 410
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 5-292 6.54e-21

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 95.30  E-value: 6.54e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277   5 GILFSTLVFGPACGFILGSVCTKVYVDavfdTRKLDITPDD--PRWIGAWWGGFLLCGALLFLSALFMFGFPQALderql 82
Cdd:cd17405 129 GIAHSAYLIGYLLGYVGGLPNFQPPPN----EKSVEIEVNKvyQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSL----- 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277  83 gggggeseqamlppslapegpaPGrrgsvlgsdadaglsvcehlrviprvtrhLLSNPVFSCITLAACMEIAVVAGFAAF 162
Cdd:cd17405 200 ----------------------PG-----------------------------LLKNPLLLCQAICKATEYLTFIGALEF 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47205277 163 LGKYLEQQFHLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAVRMAMLVNLVSTACYVSFLFLGCDTGPVAGV 242
Cdd:cd17405 229 LPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGI 308

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47205277 243 TVNYsnETSPSRSPPAPSCISNCNCRTASASPVCGSNAVTYLSACFAGCT 292
Cdd:cd17405 309 NEDY--DGYGQLGNLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCK 356
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
 261-303 4.88e-13

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 63.48  E-value: 4.88e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 47205277 261 CISNCNCRTASASPVCGSNAVTYLSACFAGCT-------RANLSGCWCVS 303
Cdd:cd01330   5 CNSNCSCSESAYSPVCGENGITYFSPCHAGCTnstgsggSKIYTNCSCVG 54
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 263-298 2.49e-05

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 41.71  E-value: 2.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47205277   263 SNCNCRTASASPVCGSNAVTYLSAC---FAGCTRANLSG 298
Cdd:pfam07648   2 CNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVK 40
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
 269-316 2.57e-04

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 38.41  E-value: 2.57e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47205277 269 TASASPVCGSNAVTYLSACFAGCTRanlsgcwCVSGSSAQaVASPGRC 316
Cdd:cd00104   2 PKEYDPVCGSDGKTYSNECHLGCAA-------CRSGRSIT-VAHNGPC 41
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
 261-316 5.51e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 34.96  E-value: 5.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 47205277    261 CISNCncrTASASPVCGSNAVTYLSACFAGCTRanlsgcwCVSGSSAQaVASPGRC 316
Cdd:smart00280   2 CPEAC---PREYDPVCGSDGVTYSNECHLCKAA-------CESGKSIE-VKHDGPC 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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