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Conserved domains on  [gi|47216442|emb|CAG01993|]
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unnamed protein product, partial [Tetraodon nigroviridis]

Protein Classification

Int_alpha and Integrin_alpha2 domain-containing protein( domain architecture ID 12192668)

protein containing domains VCBS, Int_alpha, and Integrin_alpha2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 444-903 2.52e-156

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 468.72  E-value: 2.52e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   444 RPVINVKKDIQLSTKEIDLTKKNCGNT----FCLEVKACFSYTANPRsYSPRLTVVYSLEADAEnRKKGLISRAVFIEGa 519
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQ-KKKGLPPRVLFLDS- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   520 tKSYNSRGTVVLNSQGMVECVNRQLAIQENIKDKLSGIPIDVSVEIQdtKRKRRQSSFSQLPPVLDANVNNMVRSMVPFR 599
Cdd:pfam08441  78 -QQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   600 KEgCGNDNICQSNLALSYRYGYMAADdisfvplelengiPVIKLSNQKNVALEVNVTNLnGDDAYEASMVAAFLSSLTYS 679
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   680 EFRVPlnvSLKHPVSCTANKNGS--LVDCELGNPFKRNSEAIFYIIMGTSGISLDTNEVEVELKFETTSEQQ-ALMAVKA 756
Cdd:pfam08441 220 GVRRE---GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   757 KAKVAILLQLSVSGQALPSQAyFSGKVIGEEAIK--TESEMGSAITHRFKIINLGKSLTEAAVLEIDWPKETADEKWLLY 834
Cdd:pfam08441 297 KVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWLLY 375

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47216442   835 LMNIslSGVKQINCSPKGEINPRQ----KAPRSRRAAKNSLEGDKGTISRYTDEKK---SQTLSCDQGAKCVKIKC 903
Cdd:pfam08441 376 LLDV--QGQGKGECSPQNEINPLNltqsLESSKPLRTSRVHHVVKRRDVLKSEKATqtaSVLLSCDSGARCVVIRC 449
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 257-295 3.52e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47216442   257 FGYALAVLDLNGDRWEDLVVGAPQYFEKEkeiGGAVYVY 295
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 265-333 5.44e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   265 DLNGDRWEDLVVGAPqyfekekeigGAVYVYVNN-QGMWDKITPVRIDGPQDSMfGLAVAnlgDINQDGY 333
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAVG---DLDGDGR 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 194-239 6.24e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47216442    194 PNSYLGFSLDTGKRLVKQDQLTVVAGAPRANHS---GAVVLLRKGPDTS 239
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 410-449 3.97e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47216442    410 MFGYSLASNMDLDKNSYPDLAVGS-LSDEVFVYRARPVINV 449
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFG 44
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 444-903 2.52e-156

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 468.72  E-value: 2.52e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   444 RPVINVKKDIQLSTKEIDLTKKNCGNT----FCLEVKACFSYTANPRsYSPRLTVVYSLEADAEnRKKGLISRAVFIEGa 519
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQ-KKKGLPPRVLFLDS- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   520 tKSYNSRGTVVLNSQGMVECVNRQLAIQENIKDKLSGIPIDVSVEIQdtKRKRRQSSFSQLPPVLDANVNNMVRSMVPFR 599
Cdd:pfam08441  78 -QQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   600 KEgCGNDNICQSNLALSYRYGYMAADdisfvplelengiPVIKLSNQKNVALEVNVTNLnGDDAYEASMVAAFLSSLTYS 679
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   680 EFRVPlnvSLKHPVSCTANKNGS--LVDCELGNPFKRNSEAIFYIIMGTSGISLDTNEVEVELKFETTSEQQ-ALMAVKA 756
Cdd:pfam08441 220 GVRRE---GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   757 KAKVAILLQLSVSGQALPSQAyFSGKVIGEEAIK--TESEMGSAITHRFKIINLGKSLTEAAVLEIDWPKETADEKWLLY 834
Cdd:pfam08441 297 KVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWLLY 375

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47216442   835 LMNIslSGVKQINCSPKGEINPRQ----KAPRSRRAAKNSLEGDKGTISRYTDEKK---SQTLSCDQGAKCVKIKC 903
Cdd:pfam08441 376 LLDV--QGQGKGECSPQNEINPLNltqsLESSKPLRTSRVHHVVKRRDVLKSEKATqtaSVLLSCDSGARCVVIRC 449
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 257-295 3.52e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47216442   257 FGYALAVLDLNGDRWEDLVVGAPQYFEKEkeiGGAVYVY 295
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 255-295 9.52e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 52.38  E-value: 9.52e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47216442    255 SSFGYALA-VLDLNGDRWEDLVVGAPQYFEKEKeiGGAVYVY 295
Cdd:smart00191   3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVY 42
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 265-333 5.44e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   265 DLNGDRWEDLVVGAPqyfekekeigGAVYVYVNN-QGMWDKITPVRIDGPQDSMfGLAVAnlgDINQDGY 333
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAVG---DLDGDGR 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 194-239 6.24e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47216442    194 PNSYLGFSLDTGKRLVKQDQLTVVAGAPRANHS---GAVVLLRKGPDTS 239
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 410-449 3.97e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47216442    410 MFGYSLASNMDLDKNSYPDLAVGS-LSDEVFVYRARPVINV 449
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-333 6.83e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|
gi 47216442    314 QDSMFGLAVANLGDINQDGY 333
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGY 20
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 444-903 2.52e-156

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 468.72  E-value: 2.52e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   444 RPVINVKKDIQLSTKEIDLTKKNCGNT----FCLEVKACFSYTANPRsYSPRLTVVYSLEADAEnRKKGLISRAVFIEGa 519
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQ-KKKGLPPRVLFLDS- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   520 tKSYNSRGTVVLNSQGMVECVNRQLAIQENIKDKLSGIPIDVSVEIQdtKRKRRQSSFSQLPPVLDANVNNMVRSMVPFR 599
Cdd:pfam08441  78 -QQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   600 KEgCGNDNICQSNLALSYRYGYMAADdisfvplelengiPVIKLSNQKNVALEVNVTNLnGDDAYEASMVAAFLSSLTYS 679
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTNL-GEDAYEAELYVTLPPGLDYS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   680 EFRVPlnvSLKHPVSCTANKNGS--LVDCELGNPFKRNSEAIFYIIMGTSGISLDTNEVEVELKFETTSEQQ-ALMAVKA 756
Cdd:pfam08441 220 GVRRE---GSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   757 KAKVAILLQLSVSGQALPSQAyFSGKVIGEEAIK--TESEMGSAITHRFKIINLGKSLTEAAVLEIDWPKETADEKWLLY 834
Cdd:pfam08441 297 KVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKWLLY 375

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47216442   835 LMNIslSGVKQINCSPKGEINPRQ----KAPRSRRAAKNSLEGDKGTISRYTDEKK---SQTLSCDQGAKCVKIKC 903
Cdd:pfam08441 376 LLDV--QGQGKGECSPQNEINPLNltqsLESSKPLRTSRVHHVVKRRDVLKSEKATqtaSVLLSCDSGARCVVIRC 449
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 257-295 3.52e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47216442   257 FGYALAVLDLNGDRWEDLVVGAPQYFEKEkeiGGAVYVY 295
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 255-295 9.52e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 52.38  E-value: 9.52e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47216442    255 SSFGYALA-VLDLNGDRWEDLVVGAPQYFEKEKeiGGAVYVY 295
Cdd:smart00191   3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVY 42
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 265-333 5.44e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216442   265 DLNGDRWEDLVVGAPqyfekekeigGAVYVYVNN-QGMWDKITPVRIDGPQDSMfGLAVAnlgDINQDGY 333
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAVG---DLDGDGR 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 194-239 6.24e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47216442    194 PNSYLGFSLDTGKRLVKQDQLTVVAGAPRANHS---GAVVLLRKGPDTS 239
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 410-449 3.97e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47216442    410 MFGYSLASNMDLDKNSYPDLAVGS-LSDEVFVYRARPVINV 449
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-333 6.83e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|
gi 47216442    314 QDSMFGLAVANLGDINQDGY 333
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGY 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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