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Conserved domains on  [gi|47682206|gb|AAH69858|]
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E430018J23Rik protein, partial [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-311 2.47e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 151 PHQCPDCGKSFTQRSTLVAHMYT--HIGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 224
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 225 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 293
Cdd:COG5048 369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 47682206 294 SCPDCGRcFRQSSDMAAH 311
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
86-160 1.46e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.46e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47682206  86 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPHQCPDCGKS 160
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-311 2.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 151 PHQCPDCGKSFTQRSTLVAHMYT--HIGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 224
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 225 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 293
Cdd:COG5048 369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 47682206 294 SCPDCGRcFRQSSDMAAH 311
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-304 1.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|..
gi 47682206   283 HMRTHTGEKPYSCPDCGRCFRQ 304
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
86-160 1.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.46e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47682206  86 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPHQCPDCGKS 160
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 98-160 2.33e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.14  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47682206   98 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 160
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
zf-H2C2_2 pfam13465
Zinc-finger double domain;
138-163 2.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 47682206   138 SLSMHRAIHRGERPHQCPDCGKSFTQ 163
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-311 2.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 151 PHQCPDCGKSFTQRSTLVAHMYT--HIGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 224
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47682206 225 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 293
Cdd:COG5048 369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 47682206 294 SCPDCGRcFRQSSDMAAH 311
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-304 1.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|..
gi 47682206   283 HMRTHTGEKPYSCPDCGRCFRQ 304
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
86-160 1.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.46e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47682206  86 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPHQCPDCGKS 160
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 98-160 2.33e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.14  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47682206   98 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 160
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
zf-H2C2_2 pfam13465
Zinc-finger double domain;
138-163 2.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 47682206   138 SLSMHRAIHRGERPHQCPDCGKSFTQ 163
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-133 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|...
gi 47682206   111 LVEHLYTHTGEKPFQCPDCDKYF 133
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 152-174 3.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|...
gi 47682206   152 HQCPDCGKSFTQRSTLVAHMYTH 174
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 293-315 8.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|...
gi 47682206   293 YSCPDCGRCFRQSSDMAAHRRTH 315
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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