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Conserved domains on  [gi|48675901|ref|NP_001001615|]
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cadherin-2 precursor [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 36-126 1.10e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 135.92  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    36 LCKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPeDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKE 115
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 48675901   116 TQEEWQMKVKL 126
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-383 4.14e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.14e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 278 NGTVPEGSKPGTYVMTVTAIDADDPNaqNGMLRYRILSQapssPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 357
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 48675901 358 DMEGNPtygLSNTATAVITVTDVNDN 383
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 849-908 1.20e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.20e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   849 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 908
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 513-607 1.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 513 EGLLAGSMLTTFTARDPDRYMQQTsLRYSKLS-DPANWLKIDPVNGQITTTAVLDREsiyvQNNMYNATFLASDNGIPPM 591
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGE-VTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 48675901 592 SGTGTLQIYLLDINDN 607
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-268 6.04e-21

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 88.17  E-value: 6.04e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 168 IPPINLPENSRGPfpQELVRIRSDRDKSLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 48675901 248 NGNQVENPIDIVINVIDMNDN 268
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-498 6.17e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 6.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 391 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 469
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*....
gi 48675901 470 ENqvplakGIQHPPQSTATVSITVIDVNE 498
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-707 7.62e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 7.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   615 EATTCETLQPNA--INITAVDPDIDPNAGPFAFELPDSPPsikRNWTIVRISGDhaqLSL--RIRFLEAGIYDVPIVITD 690
Cdd:pfam00028   2 SASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGD---ISTtkPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 48675901   691 SGNPHASSTSVLKVKVC 707
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 36-126 1.10e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 135.92  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    36 LCKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPeDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKE 115
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 48675901   116 TQEEWQMKVKL 126
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 37-124 1.92e-32

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 120.85  E-value: 1.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901     37 CKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPeDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKET 116
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 48675901    117 QEEWQMKV 124
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-383 4.14e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.14e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 278 NGTVPEGSKPGTYVMTVTAIDADDPNaqNGMLRYRILSQapssPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 357
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 48675901 358 DMEGNPtygLSNTATAVITVTDVNDN 383
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 849-908 1.20e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.20e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   849 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 908
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-385 8.72e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 8.72e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    295 TAIDADDPnaQNGMLRYRILSQAPsspsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 374
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 48675901    375 ITVTDVNDNPP 385
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
278-378 1.14e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   278 NGTVPEGSKPGTYVMTVTAIDADDPnaQNGMLRYRILSQapssPSPNMFTINNETGDIiTVAAGLDREKVQQYTLIIQAT 357
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 48675901   358 DmegNPTYGLSNTATAVITVT 378
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 513-607 1.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 513 EGLLAGSMLTTFTARDPDRYMQQTsLRYSKLS-DPANWLKIDPVNGQITTTAVLDREsiyvQNNMYNATFLASDNGIPPM 591
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGE-VTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 48675901 592 SGTGTLQIYLLDINDN 607
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-268 6.04e-21

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 88.17  E-value: 6.04e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 168 IPPINLPENSRGPfpQELVRIRSDRDKSLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 48675901 248 NGNQVENPIDIVINVIDMNDN 268
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
509-602 1.88e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   509 VRQEEGLLAGSMLTTFTARDPDRYmQQTSLRYSKLSD-PANWLKIDPVNGQITTTAVLDRESIyvqnNMYNATFLASDNG 587
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 48675901   588 IPPMSGTGTLQIYLL 602
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-498 6.17e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 6.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 391 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 469
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*....
gi 48675901 470 ENqvplakGIQHPPQSTATVSITVIDVNE 498
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
392-494 3.46e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   392 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 470
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 48675901   471 NQVPlakgiqHPPQSTATVSITVI 494
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 525-609 3.65e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 3.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    525 TARDPDRYMQQTsLRYSKLS-DPANWLKIDPVNGQITTTAVLDRESIyvqnNMYNATFLASDNGIPPMSGTGTLQIYLLD 603
Cdd:smart00112   1 SATDADSGENGK-VTYSILSgNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 48675901    604 INDNAP 609
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-270 3.42e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 3.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    190 SDRDKSLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDVNGNQVENPIDIVINVIDMNDNR 269
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 48675901    270 P 270
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 409-500 2.61e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.61e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    409 TVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 488
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 48675901    489 VSITVIDVNESP 500
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
169-263 1.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   169 PPINLPENSR-GPFPQELVRIRSDRDKSLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 48675901   248 NGNQVENPIDIVINVI 263
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
615-707 7.62e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 7.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   615 EATTCETLQPNA--INITAVDPDIDPNAGPFAFELPDSPPsikRNWTIVRISGDhaqLSL--RIRFLEAGIYDVPIVITD 690
Cdd:pfam00028   2 SASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGD---ISTtkPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 48675901   691 SGNPHASSTSVLKVKVC 707
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-712 2.41e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.84  E-value: 2.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 615 EATTCETLQPNA--INITAVDPDIDPNaGPFAFELpdSPPSIKRNWTIVRISGDhaqLSLR--IRFLEAGIYDVPIVITD 690
Cdd:cd11304   3 EVSVPENAPPGTvvLTVSATDPDSGEN-GEVTYSI--VSGNEDGLFSIDPSTGE---ITTAkpLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 48675901 691 SGNPHASSTSVLKVKVcqCDIN 712
Cdd:cd11304  77 GGGPPLSSTATVTITV--LDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 630-712 1.32e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    630 TAVDPDIDPNaGPFAFELpdSPPSIKRNWTIVRISGDHaQLSLRIRFLEAGIYDVPIVITDSGNPHASSTSVLKVKVcqC 709
Cdd:smart00112   1 SATDADSGEN-GKVTYSI--LSGNDDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV--L 74


                   ...
gi 48675901    710 DIN 712
Cdd:smart00112  75 DVN 77
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 36-126 1.10e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 135.92  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    36 LCKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPeDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKE 115
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 48675901   116 TQEEWQMKVKL 126
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 37-124 1.92e-32

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 120.85  E-value: 1.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901     37 CKMGFPEDVHSAVVSRSVHGGQPLLNVRFQSCDENRKIYFGSSEPeDFRVGEDGVVYAERSFQLSAEPTEFVVSARDKET 116
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 48675901    117 QEEWQMKV 124
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-383 4.14e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.14e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 278 NGTVPEGSKPGTYVMTVTAIDADDPNaqNGMLRYRILSQapssPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 357
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 48675901 358 DMEGNPtygLSNTATAVITVTDVNDN 383
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 849-908 1.20e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.20e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   849 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 908
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-385 8.72e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 8.72e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    295 TAIDADDPnaQNGMLRYRILSQAPsspsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 374
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 48675901    375 ITVTDVNDNPP 385
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
278-378 1.14e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   278 NGTVPEGSKPGTYVMTVTAIDADDPnaQNGMLRYRILSQapssPSPNMFTINNETGDIiTVAAGLDREKVQQYTLIIQAT 357
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 48675901   358 DmegNPTYGLSNTATAVITVT 378
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 513-607 1.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 513 EGLLAGSMLTTFTARDPDRYMQQTsLRYSKLS-DPANWLKIDPVNGQITTTAVLDREsiyvQNNMYNATFLASDNGIPPM 591
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGE-VTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 48675901 592 SGTGTLQIYLLDINDN 607
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-268 6.04e-21

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 88.17  E-value: 6.04e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 168 IPPINLPENSRGPfpQELVRIRSDRDKSLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 48675901 248 NGNQVENPIDIVINVIDMNDN 268
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
509-602 1.88e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   509 VRQEEGLLAGSMLTTFTARDPDRYmQQTSLRYSKLSD-PANWLKIDPVNGQITTTAVLDRESIyvqnNMYNATFLASDNG 587
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 48675901   588 IPPMSGTGTLQIYLL 602
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-498 6.17e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 6.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 391 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 469
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*....
gi 48675901 470 ENqvplakGIQHPPQSTATVSITVIDVNE 498
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
392-494 3.46e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   392 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 470
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 48675901   471 NQVPlakgiqHPPQSTATVSITVI 494
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 525-609 3.65e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 3.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    525 TARDPDRYMQQTsLRYSKLS-DPANWLKIDPVNGQITTTAVLDRESIyvqnNMYNATFLASDNGIPPMSGTGTLQIYLLD 603
Cdd:smart00112   1 SATDADSGENGK-VTYSILSgNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 48675901    604 INDNAP 609
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-268 5.34e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 5.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 171 INLPENSrgPFPQELVRIR-SDRDKSL--SLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:cd11304   4 VSVPENA--PPGTVVLTVSaTDPDSGEngEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 48675901 248 NGNQVENPIDIVINVIDMNDN 268
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-270 3.42e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 3.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    190 SDRDKSLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDVNGNQVENPIDIVINVIDMNDNR 269
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 48675901    270 P 270
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 409-500 2.61e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.61e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    409 TVTDKDQPhtPAWNARYQMTGGDPTGQFTIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 488
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 48675901    489 VSITVIDVNESP 500
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
169-263 1.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   169 PPINLPENSR-GPFPQELVRIRSDRDKSLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDV 247
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 48675901   248 NGNQVENPIDIVINVI 263
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
615-707 7.62e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 7.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901   615 EATTCETLQPNA--INITAVDPDIDPNAGPFAFELPDSPPsikRNWTIVRISGDhaqLSL--RIRFLEAGIYDVPIVITD 690
Cdd:pfam00028   2 SASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGD---ISTtkPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 48675901   691 SGNPHASSTSVLKVKVC 707
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-712 2.41e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.84  E-value: 2.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901 615 EATTCETLQPNA--INITAVDPDIDPNaGPFAFELpdSPPSIKRNWTIVRISGDhaqLSLR--IRFLEAGIYDVPIVITD 690
Cdd:cd11304   3 EVSVPENAPPGTvvLTVSATDPDSGEN-GEVTYSI--VSGNEDGLFSIDPSTGE---ITTAkpLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 48675901 691 SGNPHASSTSVLKVKVcqCDIN 712
Cdd:cd11304  77 GGGPPLSSTATVTITV--LDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 630-712 1.32e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675901    630 TAVDPDIDPNaGPFAFELpdSPPSIKRNWTIVRISGDHaQLSLRIRFLEAGIYDVPIVITDSGNPHASSTSVLKVKVcqC 709
Cdd:smart00112   1 SATDADSGEN-GKVTYSI--LSGNDDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV--L 74


                   ...
gi 48675901    710 DIN 712
Cdd:smart00112  75 DVN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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