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Conserved domains on  [gi|489972043|ref|WP_003875243|]
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MULTISPECIES: ROK family protein [Mycobacterium avium complex (MAC)]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase and/or a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
PubMed:  20512568

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-262 1.39e-129

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 366.89  E-value: 1.39e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKLLTPQPATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVTHGVVQTAANVDKAW 103
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 104 IGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLTFGTGIGSAVIHNGTLIPNTELGHLEVGGKEAE 183
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489972043 184 QRAASSVKERHGWSYEKWAKQVTRVLVSIENALWPDLFIAGGGISRKADKWLPLLENRTPVVAAALLNTAGIVGAAMAA 262
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-262 1.39e-129

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 366.89  E-value: 1.39e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKLLTPQPATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVTHGVVQTAANVDKAW 103
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 104 IGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLTFGTGIGSAVIHNGTLIPNTELGHLEVGGKEAE 183
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489972043 184 QRAASSVKERHGWSYEKWAKQVTRVLVSIENALWPDLFIAGGGISRKADKWLPLLENRTPVVAAALLNTAGIVGAAMAA 262
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 25-262 2.37e-32

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 120.39  E-value: 2.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATPSAVAKTIAAVVDAFEWTGP--------LGVTYPGVV--THGVVQ 94
Cdd:COG1940    9 GIDIGGTKIKAALVDLDGEVL--ARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPVdpETGVVL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  95 TAANVDkAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNqSGLVVLLTFGTGIGSAVIHNGTLIPNT---- 170
Cdd:COG1940   87 NAPNLP-GWRGVPLAELLEERL-GLPVFVENDANAAALAEAWFGAGRG-ADNVVYLTLGTGIGGGIVINGKLLRGAngna 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 171 -ELGHL-------------------------------------EVGGKEAEQRAASSVKERHGWsYEKWAKQVTRVLVSI 212
Cdd:COG1940  164 gEIGHMpvdpdgplcgcgnrgcletyasgpallrrarelggaeKLTAEELFAAARAGDPLALEV-LDEAARYLGIGLANL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489972043 213 ENALWPDLFIAGGGISRKADKWLPLLE------------NRTPVVAAALLNTAGIVGAAMAA 262
Cdd:COG1940  243 INLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 25-259 4.16e-16

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 76.22  E-value: 4.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043   25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATPSAVAKTIAAVVD----AFEWTGPLGVTYPGVV--THGVVQTAAN 98
Cdd:pfam00480   2 GIDIGGTKIAAALFDEEGEIL--ARERVPTPTTTTEETLVDAIAFFVDsaqrKFGELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043   99 VDkaWIGTNARDIISAELNgQEVTVLNDADAAGLAEEHYGAGRNQSgLVVLLTFGTGIGSAVIHNGTLI-----PNTELG 173
Cdd:pfam00480  80 IG--WDNFDLVEKLEERFN-VPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  174 HLEVG-------------------GKEAEQRA--------ASSVKERHGWSYEKWAKQVTRV-------LVSIENALWPD 219
Cdd:pfam00480 156 HIQLDpngpkcgcgnhgcletiasGRALEKRYqqkgedleGKDIIVLAEQGDEVAEEAVERLarylakaIANLINLFDPQ 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489972043  220 LFIAGGGISrKADKWLPLLENRTP-------------VVAAALLNTAGIVGAA 259
Cdd:pfam00480 236 AIVLGGGVS-NADGLLEAIRSLVKkylngylpvppviIVAASLGDNAGALGAA 287
PRK09557 PRK09557
fructokinase; Reviewed
 25-164 3.57e-07

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 50.41  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKggIVDMDTGlliGE---RVKLLTPQ---PATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVT--HGVVQta 96
Cdd:PRK09557   4 GIDLGGTKIE--VIALDDA---GEelfRKRLPTPRddyQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISpyTGLVK-- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043  97 aNVDKAWIGTNARDIISAELNGQEVTVLNDADAAGLAEEHYGAGRNqSGLVVLLTFGTGIGSAVIHNG 164
Cdd:PRK09557  77 -NANSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAG-KQTVFAVIIGTGCGAGVAING 142
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-262 1.39e-129

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 366.89  E-value: 1.39e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKLLTPQPATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVTHGVVQTAANVDKAW 103
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 104 IGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLTFGTGIGSAVIHNGTLIPNTELGHLEVGGKEAE 183
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489972043 184 QRAASSVKERHGWSYEKWAKQVTRVLVSIENALWPDLFIAGGGISRKADKWLPLLENRTPVVAAALLNTAGIVGAAMAA 262
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 25-262 2.37e-32

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 120.39  E-value: 2.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATPSAVAKTIAAVVDAFEWTGP--------LGVTYPGVV--THGVVQ 94
Cdd:COG1940    9 GIDIGGTKIKAALVDLDGEVL--ARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPVdpETGVVL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  95 TAANVDkAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNqSGLVVLLTFGTGIGSAVIHNGTLIPNT---- 170
Cdd:COG1940   87 NAPNLP-GWRGVPLAELLEERL-GLPVFVENDANAAALAEAWFGAGRG-ADNVVYLTLGTGIGGGIVINGKLLRGAngna 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 171 -ELGHL-------------------------------------EVGGKEAEQRAASSVKERHGWsYEKWAKQVTRVLVSI 212
Cdd:COG1940  164 gEIGHMpvdpdgplcgcgnrgcletyasgpallrrarelggaeKLTAEELFAAARAGDPLALEV-LDEAARYLGIGLANL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489972043 213 ENALWPDLFIAGGGISRKADKWLPLLE------------NRTPVVAAALLNTAGIVGAAMAA 262
Cdd:COG1940  243 INLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 25-260 3.28e-32

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 118.33  E-value: 3.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATPSAVAKTIAAVVDAFEWTGPL-------GVTYPGVV--THGVVQT 95
Cdd:cd23763    2 GIDIGGTKIRAALVDLDGEIL--ARERVPTPAEEGPEAVLDRIAELIEELLAEAGVrerilgiGIGVPGPVdpETGIVLF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  96 AANVdKAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVlLTFGTGIGSAVIHNGTLIPNT----- 170
Cdd:cd23763   80 APNL-PWWKNVPLRELLEERL-GLPVVVENDANAAALGEAWFGAGRGVRNFVY-ITLGTGIGGGIIIDGKLYRGAngaag 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 171 ELGHLEVggkeaeqraassvkerhgwsYEKWAKQVTRVLVSIENALWPDLFIAGGGISRKADKWLPLLE----------- 239
Cdd:cd23763  157 EIGHITV--------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIReavrrralppl 216

                        250       260
                 ....*....|....*....|..
gi 489972043 240 -NRTPVVAAALLNTAGIVGAAM 260
Cdd:cd23763  217 rRRVRIVPSELGDDAGLLGAAA 238
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 25-259 1.37e-30

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 115.35  E-value: 1.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDmDTGLLIgERVKLLTP----QPATPSAVAKTIAAVVDAFEWTGpLGVTYPGVVTH--GVVQTAAN 98
Cdd:cd24068    4 GIDIGGTKIKYGLVD-ADGEIL-EKDSVPTPaskgGDAILERLLEIIAELKEKYDIEG-IGISSAGQVDPktGEVIYATD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  99 VDKAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGlVVLLTFGTGIGSAVIHNGTLIPNT-----ELG 173
Cdd:cd24068   81 NLPGWTGTNLKEELEERF-GLPVAVENDVNCAALAEKWLGAAKGLDD-FLCLTLGTGIGGAIILDGRLYRGAngsagELG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 174 HLEV---------GGKEAEQRAAS------SVKERHG---WS------------------YEKWAKQVTRVLVSIENALW 217
Cdd:cd24068  159 HMVVdpggrpcccGGKGCLEQYASgtalvrRVAEALGepgIDgreifdladagdplakevVEEFAEDLATGLANLVHIFD 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489972043 218 PDLFIAGGGISRKADKWLPLLE------------NRTPVVAAALLNTAGIVGAA 259
Cdd:cd24068  239 PEVIVIGGGISAQGELFLEELReelrkllmppllDATKIEPAKLGNDAGLLGAA 292
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 25-259 9.68e-22

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 92.03  E-value: 9.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERVklltPQPATPSAVAKTIAAVVDAFEWTGPL---GVTYPGVVT--HGVVQTAANV 99
Cdd:cd24061    3 GVDIGGTKIAAGVVDEEGEILATERV----PTPPTADGIVDAIVEAVEELREGHDVsavGVAAAGFVDadRATVLFAPNI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 100 dkAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGlVVLLTFGTGIGSAVIHNGTLIPNT-----ELGH 174
Cdd:cd24061   79 --AWRNEPLKDLLEARI-GLPVVIENDANAAAWAEYRFGAGRGTDD-MVMITVGTGLGGGIVIGGKLLRGAfgiagEFGH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 175 LEV----------------------------------GGKEAEQRAASSVKER----------------HGWSYEKWAKQ 204
Cdd:cd24061  155 IRVvpdgllcgcgsrgcweqyasgralvryakeaanaTPEGAAVLLADGSVDGitgkhiseaaragdpvALDALRELARW 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043 205 VTRVLVSIENALWPDLFIAGGGISRKAD-----------KWLPLLENRT--PVVAAALLNTAGIVGAA 259
Cdd:cd24061  235 LGAGLASLAALLDPELFVIGGGVSDAGDllldpireafeRWLPGRGWRPipRLRTAQLGNDAGLIGAA 302
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 27-260 3.01e-19

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 84.93  E-value: 3.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  27 DVGGSGIKGGIVDMDtgLLIGERVKLLTPQpATPSAVAKTIAAVVDAF--EWTGpLGVTYPGVV--THGVVQTAANVDKA 102
Cdd:cd24152    6 DIGGTFIKYALVDEN--GNIIKKGKIPTPK-DSLEEFLDYIKKIIKRYdeEIDG-IAISAPGVIdpETGIIYGGGALPYL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 103 wIGTNARDIISAELNgQEVTVLNDADAAGLAEEHYGAGRNQSGlVVLLTFGTGIGSAVIHNGTLIPNT-----ELGHLEV 177
Cdd:cd24152   82 -KGFNLKEELEERCN-LPVSIENDAKCAALAELWLGSLKGIKN-GAVIVLGTGIGGAIIIDGKLYRGShffagEFSYLLT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 178 GGKEAEQRAAS----------SVKERHGW---------------------SYEKWAKQVTRVLVSIENALWPDLFIAGGG 226
Cdd:cd24152  159 DDDDKDLLFFSglasmfglvkRYNKAKGLepldgeeifekyakgdeaakkILDEYIRNLAKLIYNIQYILDPEVIVIGGG 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489972043 227 IS-------------RKADKWLPLLENRTPVVAAALLNTAGIVGAAM 260
Cdd:cd24152  239 ISeqplfiedlkkevNEILANRPGSIPKPEIKACKFGNDANLLGALY 285
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 25-259 4.16e-16

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 76.22  E-value: 4.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043   25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATPSAVAKTIAAVVD----AFEWTGPLGVTYPGVV--THGVVQTAAN 98
Cdd:pfam00480   2 GIDIGGTKIAAALFDEEGEIL--ARERVPTPTTTTEETLVDAIAFFVDsaqrKFGELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043   99 VDkaWIGTNARDIISAELNgQEVTVLNDADAAGLAEEHYGAGRNQSgLVVLLTFGTGIGSAVIHNGTLI-----PNTELG 173
Cdd:pfam00480  80 IG--WDNFDLVEKLEERFN-VPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  174 HLEVG-------------------GKEAEQRA--------ASSVKERHGWSYEKWAKQVTRV-------LVSIENALWPD 219
Cdd:pfam00480 156 HIQLDpngpkcgcgnhgcletiasGRALEKRYqqkgedleGKDIIVLAEQGDEVAEEAVERLarylakaIANLINLFDPQ 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489972043  220 LFIAGGGISrKADKWLPLLENRTP-------------VVAAALLNTAGIVGAA 259
Cdd:pfam00480 236 AIVLGGGVS-NADGLLEAIRSLVKkylngylpvppviIVAASLGDNAGALGAA 287
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 25-261 1.27e-15

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 74.67  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDmdtglliGERV--KLLTPQPATPS-AVAKTIAAVVDAFEWTGP----LGVTYPGVVTH--GVVQT 95
Cdd:cd24065    4 GLDLGGTKIAAGVVD-------GGRIlsRLVVPTPREGGeAVLDALARAVEALQAEAPgveaVGLGVPGPLDFrrGRVRF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  96 AANVdKAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRN-QSGlvVLLTFGTGIGSAVIHNGTLIPNT---- 170
Cdd:cd24065   77 APNI-PGLTDFPIRRGLAERL-GLPVVLENDANAAALAEHHYGAARGtESS--VYVTISTGIGGGLVLGGRVLRGRhgqa 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 171 -ELGHLEV------------GGKEAeQRAASSVKERHGWSY------------------------EKWAKQVTRVLVSIE 213
Cdd:cd24065  153 gEIGHTTVlpggpmcgcglvGCLEA-LASGRALARDASFAYgrpmstaelfelaqqgepkalrivEQAAAHLGIGLANLQ 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043 214 NALWPDLFIAGGGISRKADKWLPLLENR----------TPVVAAALLNTAGIVGAAMA 261
Cdd:cd24065  232 KALDPEVFVLGGGVAQVGDYYLLPVQEAarrytegwhaPPLRLAHLGTDAGVIGAALA 289
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 25-259 7.05e-14

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 69.83  E-value: 7.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERVKLLTPQ--PATPSAVAKTIAAVVDAFEWTGpLGVTYPGVVTH--GVVQTAANVd 100
Cdd:cd24064    3 GIDLGGTDTKIGIVDENGDILKKKTIDTKVENgkEDVINRIAETVNELIEEMELLG-IGIGSPGSIDRenGIVRFSPNF- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 101 KAWIGTNARDIISaELNGQEVTVLNDADAAGLAEEHYGAGRNQSGlVVLLTFGTGIGSAVIHNGTLIPN-----TELGHL 175
Cdd:cd24064   81 PDWRNFPLVPLIE-ERTGIKVFLENDANAFALGEWWFGNAKGSNH-IIGLTLGTGVGSGVICHGQLLTGydgiaAELGHV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 176 EV------------GGKEAEQRAASSVKERHGWsYEKW------------AKQV----------------------TRVL 209
Cdd:cd24064  159 IVepngpicgcgnrGCVEAFASATAIIRYARES-RKRYpdslagesekinAKHVfdaarkndplatmvfrrvvdalAIAI 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489972043 210 VSIENALWPDLFIAGGGISRKADKWLPLLENRT------------PVVAAALLNTAGIVGAA 259
Cdd:cd24064  238 GGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTkkyvmlsfqdtySIELSNLVEDAGILGAA 299
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 24-259 2.51e-13

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 68.38  E-value: 2.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKllTPQPATPSAVAKTIAAVVDAF-EWTGP------LGVTYPG--VVTHGVVQ 94
Cdd:cd24059    4 IGVEIGRDLLSAVLCDLSGNILAREKYP--LDEKENPEEVLEKLYELIDRLlEKENIkskilgIGIGAPGplDVEKGIIL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  95 TAANVdKAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLTfGTGIGSAVIHNGTLIPN----- 169
Cdd:cd24059   82 NPPNF-PGWENIPLVELLEEKF-GIPVYLDNDANAAALAEKWYGKGKNYDNFIYILA-DEGIGAGIIINGKLYRGvdgya 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 170 TELGH--LEVGGKEA-----------------EQRAASSVKERHGWSY-----------------EKWAKQVTRVLVSIE 213
Cdd:cd24059  159 GEIGHtsIDINGPRCscgnrgclelyasipaiEKKARSALGSGRSFQLdivealqkgdpiadeviEEAAKYLGIGLVNLI 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043 214 NALWPDLFIAGGGISRKADKWLPLLE------------NRTPVVAAALLNTAGIVGAA 259
Cdd:cd24059  239 NLLNPEAIIIGGELIYLGERYLEPIEkevnsrlfgrnaREVRILKSSLGEDAPLLGAA 296
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 25-259 9.30e-13

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 66.93  E-value: 9.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDtglliGERV-KLLTPQP------ATPSAVAKTIAAVVDAFEWTGPL----GVTYPGVVT--HG 91
Cdd:cd24062    4 GIDVGGTTIKMAFLTQE-----GEIVqKWEIPTNkleggeNIITDIAESIQQLLEELGYSKEDligiGVGVPGPVDveTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  92 VVQTAANVdkAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVvLLTFGTGIGSAVIHNGTLIPNT- 170
Cdd:cd24062   79 TVEVAVNL--GWKNFPLKDKLEALT-GIPVVIDNDANAAALGEMWKGAGQGAKDLV-FITLGTGVGGGVIANGKIVHGAn 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 171 ----ELGHLEVGGKEA-----------EQRAASS---------VKERHGWSYEKWAKQ---------------------- 204
Cdd:cd24062  155 gaagEIGHITVNPEGGapcncgktgclETVASATgivriareeLEEGKGSSALRILALggeltakdvfeaakagdelala 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489972043 205 -VTRV-------LVSIENALWPDLFIAGGGISRKADKWL------------PLLENRTPVVAAALLNTAGIVGAA 259
Cdd:cd24062  235 vVDTVarylglaLANLANTLNPEKIVIGGGVSAAGEFLLspvkeyfdrftfPRVRQDTEIVLATLGNDAGVIGAA 309
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 24-175 2.48e-12

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 65.33  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVklltpqpATP----SAVAKTIAAVVDA----FEWTGPLGVTYPGVV--THGVV 93
Cdd:cd24057    3 YGFDIGGTKIEFAVFDEALQLVWTKRV-------PTPtddyAAFLAAIAELVAEadarFGVKGPVGIGIPGVIdpEDGTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  94 qTAANVDKAwIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSgLVVLLTFGTGIGSAVIHNGTLIPNT--- 170
Cdd:cd24057   76 -ITANIPAA-KGRPLRADLSARL-GRPVRIDNDANCFALSEAWDGAGRGYP-SVFGLILGTGVGGGLVVNGRLVGGRsgi 151


                 ....*..
gi 489972043 171 --ELGHL 175
Cdd:cd24057  152 agEWGHG 158
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 24-175 4.86e-12

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 64.61  E-value: 4.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDmdtGLLIGERVKLLTPQPATPSAVAKTIAA-VVDAFEWTGPLGVTYPGVVTHGVVqTAANVDKA 102
Cdd:cd24069    1 LAIDIGGTKIAAALIG---NGQIIDRRQIPTPRSGTPEALADALASlLADYQGQFDRVAVASTGIIRDGVL-TALNPKNL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489972043 103 WiGTNARDIISA--ELNGQEVTVLNDADAAGLAEEHYGAGRNQSGLvVLLTFGTGIGSAVIHNGTLI--PNTELGHL 175
Cdd:cd24069   77 G-GLSGFPLADAlqQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNL-VFITVSTGVGGGLVLNGQLLtgPNGLAGHI 151
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 26-177 5.74e-12

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 64.36  E-value: 5.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  26 VDVGGSGIKGGIVDMDtglliGERVKLLT-PQPATPSAVAKTI-----AAVVDAFEWTGPL---GVTYPGVVT--HGVVQ 94
Cdd:cd24060    5 VDLGGTNLRVAIVSMK-----GEIVKKYTqPNPKTYEERIDLIlqmcvEAASEAVKLNCRIlgvGISTGGRVNprEGIVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  95 TAANVDKAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLTfGTGIGSAVIHNGTLIPNT---- 170
Cdd:cd24060   80 HSTKLIQEWSSVDLRTPISDAL-HLPVWVDNDGNCAALAERKFGHGKGVENFVTVIT-GTGIGGGIILNHELIHGSsfca 157


                 ....*...
gi 489972043 171 -ELGHLEV 177
Cdd:cd24060  158 aELGHIVV 165
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 25-174 1.75e-11

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 62.97  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDtGLLIGERVKLLTPQPATPSAVAKTIAAVVDAFEWTGP-------LGVTYPGVVTH--GVVQT 95
Cdd:cd24076    5 GVELGVDYITVVVTDLA-GEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDsplgilgIGVGVPGLVDSedGVVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  96 AANVDkaWIGTNARDIISAELNGQeVTVLNDADAAGLAEEHYGAGRNQSGLvVLLTFGTGIGSAVIHNGTLIPNT----- 170
Cdd:cd24076   84 APNLG--WRDVPLRDLLEEALGVP-VFVDNEANAAALAEKRFGAGRGVSDL-VYLSAGVGIGAGIILDGELYRGAsgfag 159


                 ....
gi 489972043 171 ELGH 174
Cdd:cd24076  160 EIGH 163
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 25-262 3.54e-11

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 62.18  E-value: 3.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERV--KLLTPQPATPSAVAKTIAAVVDafEWTGPL---GVTYPGVVTHG--VVQTAA 97
Cdd:cd24070    5 GIDIGGTNIRIGLVDEDGKLLDFEKVpsKDLLRAGDPVEVLADLIREYIE--EAGLKPaaiVIGVPGTVDKDrrTVISTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  98 NVdKAWIGTNARDIISAELNgqeVTVLNDADAA-GLAEEHYGAGRNQSGLVVLLTFGTGIGSAVIHNGTLIPNT-----E 171
Cdd:cd24070   83 NI-PGLDGVNLADILENKLG---IPVILERDVNlLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKngvagE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 172 LGHLEVGGKE----------AEQRAA-----------------SSVKERHGWsyEKWAKQVTRVL---VSIE-NALWPDL 220
Cdd:cd24070  159 LGHIPVYGNGkpcgcgntgcLETYASgraleeiaeehypdtpiLDIFVDHGD--EPELDEFVEDLalaIATEiNILDPDA 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489972043 221 FIAGGGISRKADKWLPLLEN------RTPVVA-------AALLNTAGIVGAAMAA 262
Cdd:cd24070  237 VILGGGVIDMKGFPRETLEEyirkhlRKPYPAdnlkiiyAELGPEAGVIGAAIYA 291
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 25-177 1.40e-09

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 57.35  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERVKL-LTPQPAT-PSAVAKTIAAVV--DAFEWTGPLGVTYPG--VVTHGVVQTAAN 98
Cdd:cd24063    4 AVDIGGTWIRAGLVDEDGRILLKIRQPTpKTGDPGTvSEQVLGLIETLLskAGKDSIEGIGVSSAGplDLRKGTIVNSPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  99 VDKAWIGTnaRDIISAELNGQeVTVLNDADAAGLAEEHYGAGRNQSGLvVLLTFGTGIGSAVIHNGTLIPN-----TELG 173
Cdd:cd24063   84 IKGKEIPL--VEPLKEEFNIP-VALLNDAVAAALGEHLFGAGRGTSNL-VYITISTGIGGGVIVDGRLLLGkngnaAEVG 159


                 ....
gi 489972043 174 HLEV 177
Cdd:cd24063  160 HLVV 163
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 25-177 4.85e-08

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 52.94  E-value: 4.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERVKLltpQPATPSAVAKTIAAVVDAFEWTGPL--------GVTYPGVVTH--GVVQ 94
Cdd:cd24073    5 GVKLTEDRITAVLTDLRGNVLASHTLPL---DSGDPEAVAEAIAEAVAELLAQAGLspdrllgiGVGLPGLVDAetGICR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  95 TAANVDkaWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVlLTFGTGIGSAVIHNGTLIPNT---- 170
Cdd:cd24073   82 WSPLLG--WRDVPLAELLEERL-GLPVYVENDVNALALAEHWFGAGRGLDNFAV-VTIGRGIGCGLVVDGRLYRGAhgga 157


                 ....*...
gi 489972043 171 -ELGHLEV 177
Cdd:cd24073  158 gEIGHTTV 165
PRK09557 PRK09557
fructokinase; Reviewed
 25-164 3.57e-07

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 50.41  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKggIVDMDTGlliGE---RVKLLTPQ---PATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVT--HGVVQta 96
Cdd:PRK09557   4 GIDLGGTKIE--VIALDDA---GEelfRKRLPTPRddyQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISpyTGLVK-- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043  97 aNVDKAWIGTNARDIISAELNGQEVTVLNDADAAGLAEEHYGAGRNqSGLVVLLTFGTGIGSAVIHNG 164
Cdd:PRK09557  77 -NANSTWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAG-KQTVFAVIIGTGCGAGVAING 142
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 25-259 9.92e-07

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 48.74  E-value: 9.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLIGERVklLTPQP---ATPSAVAKTIAAVVDAFEWTGPLGVTYPGVVTH--GVVQtaaNV 99
Cdd:cd24066    3 GIDLGGTKIEGIALDRAGRELLRRRV--PTPRGdyeATLDAIADLVEEAEEELGAPATVGIGTPGSISPrtGLVK---NA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 100 DKAW-IGTN-ARDIisAELNGQEVTVLNDADAAGLAEEHYGAGRNQsGLVVLLTFGTGIGSAVIHNGTLIPNT-----EL 172
Cdd:cd24066   78 NSTWlNGKPlKADL--EARLGRPVRIENDANCFALSEATDGAGAGA-GVVFGVILGTGVGGGIVVNGRVLTGAngiagEW 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 173 GHLE------------------------------------------------VGGKEAEQRAASSVKERHgwsyekwAKQ 204
Cdd:cd24066  155 GHNPlpwpdedelpgppcycgkrgcvetflsgpalerdyarltgktlsaeeiVALARAGDAAAVATLDRF-------LDR 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489972043 205 VTRVLVSIENALWPDLFIAGGGIS-------RKADKWLPLL---ENRTPVVAAALLNTAGIVGAA 259
Cdd:cd24066  228 LGRALANVINILDPDVIVLGGGLSnidelytEGPAALARYVfsdEVETPIVKNKHGDSSGVRGAA 292
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 24-175 1.62e-06

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 48.45  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKllTPQPATPSAVAkTIAAVV---DA-FEWTGPLGVTYPGVVTH--GVVQTaA 97
Cdd:PRK13310   3 YGFDIGGTKIELGVFNEKLELQWEERVP--TPRDSYDAFLD-AVCELVaeaDQrFGCKGSVGIGIPGMPETedGTLYA-A 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  98 NVDKAwIGTNARDIISAELnGQEVTVLNDADAAGLAEEhYGAGRNQSGLVVLLTFGTGIGSAVIHNGTLIPNT-----EL 172
Cdd:PRK13310  79 NVPAA-SGKPLRADLSARL-GRDVRLDNDANCFALSEA-WDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRsyitgEF 155


                 ...
gi 489972043 173 GHL 175
Cdd:PRK13310 156 GHM 158
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 25-177 7.06e-06

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 46.25  E-value: 7.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDtGLLIGERVKLLTpQPATPSAVAKTIAAVVDAF--EWTGPL---GVTYPGVVT--HGVVQTAA 97
Cdd:cd24072    5 GIVVSPNSLRAQVGNAC-GELLGEFEYRVI-TLETPEALIDEIIDCIDRLlkLWKDRVkgiALAIQGLVDshKGVSLWSP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  98 NVdkAWIGTNARDIISAELnGQEVTVLNDADAAGLAEEHYGAGRNQSGLVVLLtFGTGIGSAVIHN-----GTLIPNTEL 172
Cdd:cd24072   83 GA--PWRNIEIKYLLEERY-GIPVFVENDCNMLALAEKWQGELRQSRDFCVIN-LDYGIGSAIVIDnklyiGASSGSGEI 158


                 ....*
gi 489972043 173 GHLEV 177
Cdd:cd24072  159 GHTKV 163
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 103-175 1.84e-05

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 44.97  E-value: 1.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489972043 103 WIGTNARDIISAELNgQEVTVLNDADAAGLAEEHYGAGRNQSGLVVlLTFGTGIGSAVIHNGTLIPNT-----ELGHL 175
Cdd:cd24071   88 WENVELKKILKEKFK-IPVFIDNDVNSFALAELWKGKGKGYSNFIC-VTVGAGIGSSLVIDGKLYTGNfggagEIGHM 163
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 25-186 1.19e-04

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 42.60  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDmdtgllIGERVKLLTPQPATPSAVAKTIAAVVDAFewtgpLGVTYPGVVTHGVVQTAANVDKAWI 104
Cdd:cd24008    3 VGDIGGTNARLALAD------AGDGSGDLLFVRKYPSADFASLEDALAAF-----LAELGAPRPKAACIAVAGPVDGGRV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043 105 G-TNA-----RDIISAELNGQEVTVLNDADAAGLA----------EEHYGAGRNQSGLVVLLTFGTGIGSAVIH---NGT 165
Cdd:cd24008   72 RlTNLdwsidAAELRKALGIGRVRLLNDFEAAAYGlpalgpedllVLYGGGGPLPGGPRAVLGPGTGLGVALLVpdgDGG 151

                        170       180
                 ....*....|....*....|..
gi 489972043 166 LIP-NTELGHLEVGGKEAEQRA 186
Cdd:cd24008  152 YVVlPSEGGHADFAPVTEEEAE 173
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 25-177 1.95e-04

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 41.76  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  25 GVDVGGSGIKGGIVDMDTGLLigERVKLLTPQPATpsavakTIAAVVDAF-EWT-----------GPLGVTyPGVVTHGV 92
Cdd:cd24067    3 GIEAGGTKFVCAVGTGDGNII--ERTEFPTTTPEE------TLQAVIDFFrEQEepidaigiasfGPIDLN-PTSPTYGY 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  93 VQTAANVdkAWIGTNARDIISAELNgqeVTVLNDAD--AAGLAEEHYGAGRNQSGLVvLLTFGTGIGSAVIHNGTLIP-- 168
Cdd:cd24067   74 ITTTPKP--GWRNFDILGALKRAFP---VPVGFDTDvnAAALAEYRWGAAKGLDSLA-YITVGTGIGVGLVVNGKPVHgl 147

                        170
                 ....*....|
gi 489972043 169 -NTELGHLEV 177
Cdd:cd24067  148 lHPEMGHIRV 157
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 24-177 7.96e-04

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 40.01  E-value: 7.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  24 FGVDVGGSGIKGGIVDMDTGLLIGERVKllTPQPATPS--AVAKTIAAVVDAF-EWTGPLGVTYPGV--VTHGVVQTAaN 98
Cdd:PRK13311   3 YGFDMGGTKIELGVFDENLQRIWHKRVP--TPREDYPQllQILRDLTEEADTYcGVQGSVGIGIPGLpnADDGTVFTA-N 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489972043  99 VDKAWIGTNARDIisAELNGQEVTVLNDADAAGLAEEHYGAGRNQSgLVVLLTFGTGIGSAVIHNGTLIPNT-----ELG 173
Cdd:PRK13311  80 VPSAMGQPLQADL--SRLIQREVRIDNDANCFALSEAWDPEFRTYP-TVLGLILGTGVGGGLIVNGSIVSGRnhitgEFG 156


                 ....
gi 489972043 174 HLEV 177
Cdd:PRK13311 157 HFRL 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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