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Conserved domains on  [gi|499175579|ref|WP_010873166|]
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MULTISPECIES: AAA-like domain-containing protein [unclassified Synechocystis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
485-845 1.71e-94

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 308.38  E-value: 1.71e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  485 RSQQGTELQRLGTSAQRQFTFDQIPGLVTALEAGNQLHHLVKADETLSQYPATSPLVSLQQILSQIAEKNVLTGHRDGVT 564
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  565 SVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL-DGNLLQTLKGHQ 642
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  643 DSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDLD-GNLIRQF 721
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  722 GLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQ-GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWST-SGKM 799
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLaTGKL 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579  800 LKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNL 845
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
691-1150 2.22e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  691 QFSPDGQTLVSVCRDGQIRLWDL--DGNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEF 768
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAalGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  769 VTRVVFTPDGKQLFSSSSNGSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNLNL 847
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  848 PAvlGAVaenaktNTIAlameneplilfntknrsrqflsdasqnldrlkFSADGQWLL-GQRGRQWQLWQLQTkSQLLKT 926
Cdd:COG2319   161 HS--GAV------TSVA--------------------------------FSPDGKLLAsGSDDGTVRLWDLAT-GKLLRT 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  927 WRTDISRVYDVDLrttptSP--QWaIAMATGSGEVQLWqgtknnqtsgnqsqgvpiELNDPIVLALGNSiqRKEPIRSVS 1004
Cdd:COG2319   200 LTGHTGAVRSVAF-----SPdgKL-LASGSADGTVRLW------------------DLATGKLLRTLTG--HSGSVRSVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1005 LHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPI 1082
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAV 333

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499175579 1083 DQIAISPDSQWIATAASDGMVRLWD-QQGNLRGEFTSTSGSLLGLDFNRQGQWLLAVAQNGDLQSWPVT 1150
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 52-367 3.12e-13

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam14516:

Pssm-ID: 476819  Cd Length: 331  Bit Score: 72.16  E-value: 3.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579    52 RQMGKSSLRVRAMHQLQQDGVVCVSIDITSLGTE--ADPQK---WYNGIITQlYLGLPlagkvalkPWLRE--REQLSPI 124
Cdd:pfam14516   40 RQMGKTSLLLRILAYAQQQGYRTVYLDFQLADKAilTDLDKflrWFCANISR-QLGLP--------PKLDDywDEDLGSK 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   125 QKLREFVETIILQTIgDRQIVIFIDEIDKVLSLPFSLDDFFSYIRFCYNQRADDHEYNRLSFALF---GVATPSDLidnk 201
Cdd:pfam14516  111 VSCTIYFEDYLLPQI-DRPLVLALDEVDRLFEYPEIAQDFLGLLRSWHEEAKNNPIWQKLRLVVVhstEVYIPLDI---- 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   202 TQTPFNIGQAIALTGFTLTEALPLSA--GLP--VDEVSAreiLGEILawtGGQPFLTQKVCELVAealqkgdldcqSQTI 277
Cdd:pfam14516  186 NQSPFNVGLPIELPEFTLEQVQELAQrhGLDwtEGQLEQ---LMALV---GGHPYLVRLALYHLA-----------QQEL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   278 atTIAQLIEEKII----------RHWEsndepvhfrtigdRLLKDQarsgQLLGLYQEILHkgaipADDSVE----QTV- 342
Cdd:pfam14516  249 --TLEELLQEAPTdtgiysdhlrRHLW-------------NLQQQP----ELAAAFKKVVS-----SSQPVEldpiQAYk 304

                          330       340
                   ....*....|....*....|....*
gi 499175579   343 LRLTGLVVKVKGQLRPYNPIYQAIF 367
Cdd:pfam14516  305 LESMGLVKLEGNQVIPSCELYRQYF 329
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
485-845 1.71e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 308.38  E-value: 1.71e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  485 RSQQGTELQRLGTSAQRQFTFDQIPGLVTALEAGNQLHHLVKADETLSQYPATSPLVSLQQILSQIAEKNVLTGHRDGVT 564
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  565 SVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL-DGNLLQTLKGHQ 642
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  643 DSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDLD-GNLIRQF 721
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  722 GLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQ-GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWST-SGKM 799
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLaTGKL 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579  800 LKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNL 845
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 552-835 2.42e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 292.70  E-value: 2.42e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  552 EKNVLTGHRDGVTSVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL 630
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  631 -DGNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIR 709
Cdd:cd00200    81 eTGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  710 LWDLD-GNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQ-GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSN 787
Cdd:cd00200   161 LWDLRtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 499175579  788 GSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWD 835
Cdd:cd00200   241 GTIRVWDLrTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
691-1150 2.22e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  691 QFSPDGQTLVSVCRDGQIRLWDL--DGNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEF 768
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAalGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  769 VTRVVFTPDGKQLFSSSSNGSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNLNL 847
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  848 PAvlGAVaenaktNTIAlameneplilfntknrsrqflsdasqnldrlkFSADGQWLL-GQRGRQWQLWQLQTkSQLLKT 926
Cdd:COG2319   161 HS--GAV------TSVA--------------------------------FSPDGKLLAsGSDDGTVRLWDLAT-GKLLRT 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  927 WRTDISRVYDVDLrttptSP--QWaIAMATGSGEVQLWqgtknnqtsgnqsqgvpiELNDPIVLALGNSiqRKEPIRSVS 1004
Cdd:COG2319   200 LTGHTGAVRSVAF-----SPdgKL-LASGSADGTVRLW------------------DLATGKLLRTLTG--HSGSVRSVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1005 LHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPI 1082
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAV 333

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499175579 1083 DQIAISPDSQWIATAASDGMVRLWD-QQGNLRGEFTSTSGSLLGLDFNRQGQWLLAVAQNGDLQSWPVT 1150
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1154 2.54e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 2.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  895 LKFSADGQWLL-GQRGRQWQLWQLQTKsQLLKTWRTDISRVYDVDlrTTPTSPQwaiaMATGS--GEVQLWQGTKNNQTS 971
Cdd:cd00200    15 VAFSPDGKLLAtGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVA--ASADGTY----LASGSsdKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  972 gnqsqgvpiELndpivlalgnsIQRKEPIRSVSLHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNG 1050
Cdd:cd00200    88 ---------TL-----------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1051 KYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWDQQ-GNLRGEFTSTSGSLLGLDF 1128
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAF 227

                         250       260
                  ....*....|....*....|....*.
gi 499175579 1129 NRQGQWLLAVAQNGDLQSWPVTPEKE 1154
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGEC 253
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
 52-367 3.12e-13

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 72.16  E-value: 3.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579    52 RQMGKSSLRVRAMHQLQQDGVVCVSIDITSLGTE--ADPQK---WYNGIITQlYLGLPlagkvalkPWLRE--REQLSPI 124
Cdd:pfam14516   40 RQMGKTSLLLRILAYAQQQGYRTVYLDFQLADKAilTDLDKflrWFCANISR-QLGLP--------PKLDDywDEDLGSK 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   125 QKLREFVETIILQTIgDRQIVIFIDEIDKVLSLPFSLDDFFSYIRFCYNQRADDHEYNRLSFALF---GVATPSDLidnk 201
Cdd:pfam14516  111 VSCTIYFEDYLLPQI-DRPLVLALDEVDRLFEYPEIAQDFLGLLRSWHEEAKNNPIWQKLRLVVVhstEVYIPLDI---- 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   202 TQTPFNIGQAIALTGFTLTEALPLSA--GLP--VDEVSAreiLGEILawtGGQPFLTQKVCELVAealqkgdldcqSQTI 277
Cdd:pfam14516  186 NQSPFNVGLPIELPEFTLEQVQELAQrhGLDwtEGQLEQ---LMALV---GGHPYLVRLALYHLA-----------QQEL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   278 atTIAQLIEEKII----------RHWEsndepvhfrtigdRLLKDQarsgQLLGLYQEILHkgaipADDSVE----QTV- 342
Cdd:pfam14516  249 --TLEELLQEAPTdtgiysdhlrRHLW-------------NLQQQP----ELAAAFKKVVS-----SSQPVEldpiQAYk 304

                          330       340
                   ....*....|....*....|....*
gi 499175579   343 LRLTGLVVKVKGQLRPYNPIYQAIF 367
Cdd:pfam14516  305 LESMGLVKLEGNQVIPSCELYRQYF 329
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 631-670 6.17e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 6.17e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579    631 DGNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWH 670
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 560-758 8.12e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 69.73  E-value: 8.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  560 RDGVTSVAISSH-KNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSP-NGKIFATAGQDQTVKIWDLD-GNLL 635
Cdd:PLN00181  532 RSKLSGICWNSYiKSQVASSNFEGVVQVWdVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINqGVSI 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  636 QTLKGhQDSVYSVSFSPD-GEILASTSRDRTVRLWHWRSGKT-LAVLGGHTKSVDDAQFSpDGQTLVSVCRDGQIRLWDL 713
Cdd:PLN00181  612 GTIKT-KANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579  714 DgnlIRQFGLPEVAFFGVNWHPN-GNLLAVAADDGTVRLWTPQGEI 758
Cdd:PLN00181  690 S---MSISGINETPLHSFMGHTNvKNFVGLSVSDGYIATGSETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
632-669 3.11e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 58.90  E-value: 3.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 499175579   632 GNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLW 669
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1069-1107 8.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 8.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 499175579   1069 GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1069-1107 3.17e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 3.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579  1069 GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
485-845 1.71e-94

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 308.38  E-value: 1.71e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  485 RSQQGTELQRLGTSAQRQFTFDQIPGLVTALEAGNQLHHLVKADETLSQYPATSPLVSLQQILSQIAEKNVLTGHRDGVT 564
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  565 SVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL-DGNLLQTLKGHQ 642
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  643 DSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDLD-GNLIRQF 721
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  722 GLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQ-GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWST-SGKM 799
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLaTGKL 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579  800 LKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNL 845
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 552-835 2.42e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 292.70  E-value: 2.42e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  552 EKNVLTGHRDGVTSVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL 630
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  631 -DGNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIR 709
Cdd:cd00200    81 eTGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  710 LWDLD-GNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQ-GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSN 787
Cdd:cd00200   161 LWDLRtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 499175579  788 GSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWD 835
Cdd:cd00200   241 GTIRVWDLrTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
536-919 7.87e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 273.71  E-value: 7.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  536 ATSPLVSLQQILSQIAEKNVLTGHRDGVTSVAISSHKNLIASASRDGTVHLWTP-QGEFLREFTGHTGSIYRVDFSPNGK 614
Cdd:COG2319    12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTAAVLSVAFSPDGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  615 IFATAGQDQTVKIWDLD-GNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFS 693
Cdd:COG2319    92 LLASASADGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  694 PDGQTLVSVCRDGQIRLWDLD-GNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLW-TPQGEIKATLSGHDEFVTR 771
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWdLATGKLLRTLTGHSGSVRS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  772 VVFTPDGKQLFSSSSNGSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNLN-LPA 849
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTG 331

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499175579  850 VLGAVAENAKTNTIALAMENEPLILFNTKNRSR-QFLSDASQNLDRLKFSADGQWLL-GQRGRQWQLWQLQT 919
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLAsGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
649-1107 1.40e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 1.40e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  649 SFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDL-DGNLIRQFGLPEVA 727
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  728 FFGVNWHPNGNLLAVAADDGTVRLW-TPQGEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWST-SGKMLKKYQG 805
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  806 YPEAIFGLALASNGALLAIGAENNLVKVWDMspksdlvnlnlpavlgavaenaktntialameneplilfnTKNRSRQFL 885
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL----------------------------------------ATGKLLRTL 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  886 SDASQNLDRLKFSADGQWLL-GQRGRQWQLWQLQTKsQLLKTWRTDISRVYDVDLrttptSP--QWaIAMATGSGEVQLW 962
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLAsGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF-----SPdgRL-LASGSADGTVRLW 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  963 --QGTKNNQTSGNQSQGVpielndpivlalgnsiqrkepiRSVSLHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGD 1039
Cdd:COG2319   274 dlATGELLRTLTGHSGGV----------------------NSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTG 331

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499175579 1040 RLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 547-752 4.76e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 4.76e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  547 LSQIAEKNVLTGHRDGVTSVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTV 625
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  626 KIWDLD-GNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCR 704
Cdd:cd00200   160 KLWDLRtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 499175579  705 DGQIRLWDLD-GNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLW 752
Cdd:cd00200   240 DGTIRVWDLRtGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
567-1157 2.11e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 2.11e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  567 AISSHKNLIASASRDGTVHLWTPQ-GEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDL-DGNLLQTLKGHQDS 644
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAAlGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  645 VYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDLDgnlirqfglp 724
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  725 evaffgvnwhpngnllavaaddgtvrlwtpQGEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWS-TSGKMLKKY 803
Cdd:COG2319   151 ------------------------------TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTL 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  804 QGYPEAIFGLALASNGALLAIGAENNLVKVWDMSpksdlvnlnlpavlgavaenaktntialameneplilfntknrsrq 883
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA---------------------------------------------- 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  884 flsdasqnldrlkfsadgqwllgqrgrqwqlwqlqtksqllktwrtdisrvydvdlrttptspqwaiamatgsgevqlwq 963
Cdd:COG2319       --------------------------------------------------------------------------------

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  964 gtknnqtsgnqsqgvpielndpivlalgnsiqrkepirsvslhptlpqlaagdeqgnltlwnfDGTLIRSIVAHGDRLNQ 1043
Cdd:COG2319   235 ---------------------------------------------------------------TGKLLRTLTGHSGSVRS 251

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1044 LQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD-QQGNLRGEFTSTSG 1121
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTG 331

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 499175579 1122 SLLGLDFNRQGQWLLAVAQNGDLQSWPVTPEKERLR 1157
Cdd:COG2319   332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
691-1150 2.22e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  691 QFSPDGQTLVSVCRDGQIRLWDL--DGNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEF 768
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAalGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  769 VTRVVFTPDGKQLFSSSSNGSVIHWST-SGKMLKKYQGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKSDLVNLNL 847
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  848 PAvlGAVaenaktNTIAlameneplilfntknrsrqflsdasqnldrlkFSADGQWLL-GQRGRQWQLWQLQTkSQLLKT 926
Cdd:COG2319   161 HS--GAV------TSVA--------------------------------FSPDGKLLAsGSDDGTVRLWDLAT-GKLLRT 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  927 WRTDISRVYDVDLrttptSP--QWaIAMATGSGEVQLWqgtknnqtsgnqsqgvpiELNDPIVLALGNSiqRKEPIRSVS 1004
Cdd:COG2319   200 LTGHTGAVRSVAF-----SPdgKL-LASGSADGTVRLW------------------DLATGKLLRTLTG--HSGSVRSVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1005 LHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPI 1082
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAV 333

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499175579 1083 DQIAISPDSQWIATAASDGMVRLWD-QQGNLRGEFTSTSGSLLGLDFNRQGQWLLAVAQNGDLQSWPVT 1150
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 594-1107 7.34e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.68  E-value: 7.34e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  594 LREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDLDGN-LLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWR 672
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  673 SGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWDLdgnlirqfglpevaffgvnwhpngnllavaaddgtvrlw 752
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--------------------------------------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  753 tPQGEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVihwstsgkmlkkyqgypeaifglalasngallaigaennlvK 832
Cdd:cd00200   123 -ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI-----------------------------------------K 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  833 VWDmspksdlvnlnlpavlgavaenaktntialameneplilfntknrsrqflsdasqnldrlkfsadgqwllgqrgrqw 912
Cdd:cd00200   161 LWD----------------------------------------------------------------------------- 163

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  913 qlwqlqtksqlLKTWRTdisrvydvdlrttptspqwaiaMATGSGEvqlwqgtknnqtsgnqsqgvpielndpivlalgn 992
Cdd:cd00200   164 -----------LRTGKC----------------------VATLTGH---------------------------------- 176

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  993 siqrKEPIRSVSLHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQ 1070
Cdd:cd00200   177 ----TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRtGE 252

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 499175579 1071 LLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:cd00200   253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1154 2.54e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 2.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  895 LKFSADGQWLL-GQRGRQWQLWQLQTKsQLLKTWRTDISRVYDVDlrTTPTSPQwaiaMATGS--GEVQLWQGTKNNQTS 971
Cdd:cd00200    15 VAFSPDGKLLAtGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVA--ASADGTY----LASGSsdKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  972 gnqsqgvpiELndpivlalgnsIQRKEPIRSVSLHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNG 1050
Cdd:cd00200    88 ---------TL-----------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1051 KYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWDQQ-GNLRGEFTSTSGSLLGLDF 1128
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAF 227

                         250       260
                  ....*....|....*....|....*.
gi 499175579 1129 NRQGQWLLAVAQNGDLQSWPVTPEKE 1154
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1030-1153 1.97e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 1.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1030 LIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD- 1107
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDl 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579 1108 QQGNLRGEFTSTSGSLLGLDFNRQGQWLLAVAQNGDLQSWPVTPEK 1153
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 547-629 8.56e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 8.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  547 LSQIAEKNVLTGHRDGVTSVAISSHKNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTV 625
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWdLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                  ....
gi 499175579  626 KIWD 629
Cdd:cd00200   286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 999-1147 2.22e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 2.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  999 PIRSVSLHPTLPQLAAGDEQGNLTLWNFD-GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWSVE-GQLLHTLK 1076
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499175579 1077 SDPLPIDQIAISPDSQWIATAASDGMVRLWD-QQGNLRGEFTSTSGSLLGLDFNRQGQWLLAVAQNGDLQSW 1147
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
 52-367 3.12e-13

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 72.16  E-value: 3.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579    52 RQMGKSSLRVRAMHQLQQDGVVCVSIDITSLGTE--ADPQK---WYNGIITQlYLGLPlagkvalkPWLRE--REQLSPI 124
Cdd:pfam14516   40 RQMGKTSLLLRILAYAQQQGYRTVYLDFQLADKAilTDLDKflrWFCANISR-QLGLP--------PKLDDywDEDLGSK 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   125 QKLREFVETIILQTIgDRQIVIFIDEIDKVLSLPFSLDDFFSYIRFCYNQRADDHEYNRLSFALF---GVATPSDLidnk 201
Cdd:pfam14516  111 VSCTIYFEDYLLPQI-DRPLVLALDEVDRLFEYPEIAQDFLGLLRSWHEEAKNNPIWQKLRLVVVhstEVYIPLDI---- 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   202 TQTPFNIGQAIALTGFTLTEALPLSA--GLP--VDEVSAreiLGEILawtGGQPFLTQKVCELVAealqkgdldcqSQTI 277
Cdd:pfam14516  186 NQSPFNVGLPIELPEFTLEQVQELAQrhGLDwtEGQLEQ---LMALV---GGHPYLVRLALYHLA-----------QQEL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   278 atTIAQLIEEKII----------RHWEsndepvhfrtigdRLLKDQarsgQLLGLYQEILHkgaipADDSVE----QTV- 342
Cdd:pfam14516  249 --TLEELLQEAPTdtgiysdhlrRHLW-------------NLQQQP----ELAAAFKKVVS-----SSQPVEldpiQAYk 304

                          330       340
                   ....*....|....*....|....*
gi 499175579   343 LRLTGLVVKVKGQLRPYNPIYQAIF 367
Cdd:pfam14516  305 LESMGLVKLEGNQVIPSCELYRQYF 329
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 631-670 6.17e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 6.17e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579    631 DGNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWH 670
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 560-758 8.12e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 69.73  E-value: 8.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  560 RDGVTSVAISSH-KNLIASASRDGTVHLW-TPQGEFLREFTGHTGSIYRVDFSP-NGKIFATAGQDQTVKIWDLD-GNLL 635
Cdd:PLN00181  532 RSKLSGICWNSYiKSQVASSNFEGVVQVWdVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINqGVSI 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  636 QTLKGhQDSVYSVSFSPD-GEILASTSRDRTVRLWHWRSGKT-LAVLGGHTKSVDDAQFSpDGQTLVSVCRDGQIRLWDL 713
Cdd:PLN00181  612 GTIKT-KANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 499175579  714 DgnlIRQFGLPEVAFFGVNWHPN-GNLLAVAADDGTVRLWTPQGEI 758
Cdd:PLN00181  690 S---MSISGINETPLHSFMGHTNvKNFVGLSVSDGYIATGSETNEV 732
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 574-719 1.29e-11

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 63.92  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  574 LIASASRDGTVHLWT--PQGEFLREFTGHTGSIYRVDFSPNGK-IFATAGQDQTVKIW--DLDGNLLQTLKGHQDSVYSV 648
Cdd:COG0823     1 LAFTLSRDGNSDIYVvdLDGGEPRRLTNSPGIDTSPAWSPDGRrIAFTSDRGGGPQIYvvDADGGEPRRLTFGGGYNASP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499175579  649 SFSPDGEILASTSR-DRTVRLWHWR-SGKTLAVLgghTKSVDDAQFSPDGQTLV-SVCRDGQIRLW--DLDGNLIR 719
Cdd:COG0823    81 SWSPDGKRLAFVSRsDGRFDIYVLDlDGGAPRRL---TDGPGSPSWSPDGRRIVfSSDRGGRPDLYvvDLDGRKRR 153
PTZ00421 PTZ00421
coronin; Provisional
 577-712 2.22e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 67.61  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  577 SASRDGTVHLWTPQGEFLR--------EFTGHTGSIYRVDFSPNGK-IFATAGQDQTVKIWDLD-GNLLQTLKGHQDSVY 646
Cdd:PTZ00421   93 TASEDGTIMGWGIPEEGLTqnisdpivHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVErGKAVEVIKCHSDQIT 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499175579  647 SVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVLGGH--TKSvDDAQFSPDGQTLVSV----CRDGQIRLWD 712
Cdd:PTZ00421  173 SLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKS-QRCLWAKRKDLIITLgcskSQQRQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 590-629 2.54e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.25  E-value: 2.54e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579    590 QGEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWD 629
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
632-669 3.11e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 58.90  E-value: 3.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 499175579   632 GNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLW 669
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 564-833 2.06e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 62.72  E-value: 2.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  564 TSVAISSHKNLIASASRDGTVHLWTPQGEFLREFTG---HTGSIYR---VDFSPNGKIFATAGQDQTVKIWDLDGNLLQT 637
Cdd:cd05819    11 QGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSfgsGDGQFNEpagVAVDSDGNLYVADTGNHRIQKFDPDGNFLAS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  638 L------KGHQDSVYSVSFSPDGEIL-ASTSRDRtVRLWHwRSGKTLAVLGGHTKSvdDAQF-SPDGqtlVSVCRDGQ-- 707
Cdd:cd05819    91 FggsgdgDGEFNGPRGIAVDSSGNIYvADTGNHR-IQKFD-PDGEFLTTFGSGGSG--PGQFnGPTG---VAVDSDGNiy 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  708 --------IRLWDLDGNLIRQFGLPEVAFFGVNwHPNGnllaVAADdgtvrlwtPQGEIKATLSGHDefvtRV-VFTPDG 778
Cdd:cd05819   164 vadtgnhrIQVFDPDGNFLTTFGSTGTGPGQFN-YPTG----IAVD--------SDGNIYVADSGNN----RVqVFDPDG 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499175579  779 KQLfssSSNGSVIhwSTSGKMlkkyqGYPeaiFGLALASNGALLAIGAENNLVKV 833
Cdd:cd05819   227 AGF---GGNGNFL--GSDGQF-----NRP---SGLAVDSDGNLYVADTGNNRIQV 268
WD40 pfam00400
WD domain, G-beta repeat;
591-629 2.30e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 56.58  E-value: 2.30e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579   591 GEFLREFTGHTGSIYRVDFSPNGKIFATAGQDQTVKIWD 629
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 656-789 2.24e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 57.37  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  656 ILASTSRDRTVRLWHWR-SGKTLAVLGGHTKSVDDAQFSPDGQTLV-SVCRDG--QIRLWDLDGNLIRQFGLPEVAFFGV 731
Cdd:COG0823     1 LAFTLSRDGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGgpQIYVVDADGGEPRRLTFGGGYNASP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499175579  732 NWHPNGNLLAVAAD-DGTVRLWT--PQGEIKATLSghdEFVTRVVFTPDGKQL-FSSSSNGS 789
Cdd:COG0823    81 SWSPDGKRLAFVSRsDGRFDIYVldLDGGAPRRLT---DGPGSPSWSPDGRRIvFSSDRGGR 139
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 673-712 2.29e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 2.29e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579    673 SGKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWD 712
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 554-587 2.35e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 2.35e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 499175579    554 NVLTGHRDGVTSVAISSHKNLIASASRDGTVHLW 587
Cdd:smart00320    6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
674-712 3.63e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 3.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579   674 GKTLAVLGGHTKSVDDAQFSPDGQTLVSVCRDGQIRLWD 712
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 565-782 5.72e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 55.28  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  565 SVAISSHKNLIASASRDGTVHLWTPQGEFLREFTGHTGSIYRVDFSPNGKIFAtAGQDQTVKIWDLDGNLLQTLKGHQDS 644
Cdd:COG3386    12 GPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGEVTVLADEYGK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  645 VYS----VSFSPDGEILASTS--RDRTVRLWHWRSGKTLAVLgghtksVDDAQ------FSPDGQTL-VSVCRDGQIRLW 711
Cdd:COG3386    91 PLNrpndGVVDPDGRLYFTDMgeYLPTGALYRVDPDGSLRVL------ADGLTfpngiaFSPDGRTLyVADTGAGRIYRF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  712 DLDGN-----------LIRQFGLPEvaffGVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEFVTRVVF-TPDGK 779
Cdd:COG3386   165 DLDADgtlgnrrvfadLPDGPGGPD----GLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTNVAFgGPDLR 240


                  ...
gi 499175579  780 QLF 782
Cdd:COG3386   241 TLY 243
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 627-753 6.97e-08

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 53.14  E-value: 6.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  627 IWDLDGNLLQTLKGHQDSVYSVSFSPDGEILA-STSRDRTVRLWHWR-SGKTLAVLGGHTKSVDDAQFSPDGQTLV-SVC 703
Cdd:COG0823    15 VVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDaDGGEPRRLTFGGGYNASPSWSPDGKRLAfVSR 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499175579  704 RDGQIRLW--DLDGNLIRQFGlpeVAFFGVNWHPNGNLLAVAAD-DGTVRLWT 753
Cdd:COG0823    95 SDGRFDIYvlDLDGGAPRRLT---DGPGSPSWSPDGRRIVFSSDrGGRPDLYV 144
WD40 pfam00400
WD domain, G-beta repeat;
555-587 7.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 7.20e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 499175579   555 VLTGHRDGVTSVAISSHKNLIASASRDGTVHLW 587
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 561-745 1.19e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 56.20  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  561 DGVTSVAISSHKNLIASASRdGTVHLWTPQGEFLREFTGHTGSIYR-VDFSPNGKIFATA----GQDQtvkIW--DLDGN 633
Cdd:COG4946   302 GYLTSFALSPDGKRVAFEAR-GEVFTVPAEKGPTRNLTNTPGVRERlPAWSPDGKSIAYFsdasGEYE---LYiaPADGS 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  634 -----LLQTLKGHqdsVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLAVL-GGHTKSVDDAQFSPDGQTLVSVCRDG- 706
Cdd:COG4946   378 gepkqLTLGDLGR---VFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDtDGYGDGISDLAWSPDSKWLAYSKPGPn 454

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 499175579  707 ---QIRLWDLDGNLIRQFGLPEVAFFGVNWHPNGNLLAVAAD 745
Cdd:COG4946   455 qlsQIFLYDVETGKTVQLTDGRYDDGSPAFSPDGKYLYFLSS 496
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1069-1107 8.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 8.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 499175579   1069 GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 755-794 1.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.53e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579    755 QGEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWS 794
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 558-834 2.09e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 50.74  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  558 GHRDGVTSVAISSHKNLIASASRDGTVHLWTPQGEFLREF------TGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDLD 631
Cdd:cd14956    10 GQFKDPRGIAVDADDNVYVADARNGRIQVFDKDGTFLRRFgttgdgPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  632 GNLLQT--LKGHQ----DSVYSVSFSPDGEIL-ASTSRDRTVRLwhwRS-GKTLAVLG------GHTKSVDDAQFSPDGQ 697
Cdd:cd14956    90 GELQTIggSSGSGpgqfNAPRGVAVDADGNLYvADFGNQRIQKF---DPdGSFLRQWGgtgiepGSFNYPRGVAVDPDGT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  698 TLVSVCRDGQIRLWDLDGNLIRQFGLPevaFFGVNW--HPNGnlLAVAaddgtvrlwtPQGEIKATLSGHDefvtRV-VF 774
Cdd:cd14956   167 LYVADTYNDRIQVFDNDGAFLRKWGGR---GTGPGQfnYPYG--IAID----------PDGNVFVADFGNN----RIqKF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  775 TPDGKQLFSSSSNGSVIHwstsgkmlkkyQGYPEaiFGLALASNGALLAIGAENNLVKVW 834
Cdd:cd14956   228 TADGTFLTSWGSPGTGPG-----------QFKNP--WGVVVDADGTVYVADSNNNRVQRF 274
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1027-1066 2.44e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 2.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 499175579   1027 DGTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWS 1066
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1069-1107 3.17e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 3.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579  1069 GQLLHTLKSDPLPIDQIAISPDSQWIATAASDGMVRLWD 1107
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 631-832 3.42e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 50.46  E-value: 3.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   631 DGNLLQTLKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHWRSGKTLA-----------------------VLGGHTKSV 687
Cdd:pfam20426  113 DGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDII 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   688 DDAQFSPDGQTLVSVCRDGQIRLWDL-DGNLIRQFglpevaffgvnWHPNGNLLA--VAADDGTVRLWTpqgeiKATLSG 764
Cdd:pfam20426  193 TCLYVSVELDIVISGSKDGTCIFHTLrEGRYVRSI-----------RHPSGCPLSklVASRHGRIVLYA-----DDDLSL 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   765 HdefvtrvVFTPDGKQLFSSSSNG--SVIHWSTSGKML--------------------KKYQGY----------PEAIFg 812
Cdd:pfam20426  257 H-------LYSINGKHIASSESNGrlNCIELSSCGEFLvcagdqgqivvrsmnslevvRRYNGIgkiitsltvtPEECF- 328

                          250       260
                   ....*....|....*....|
gi 499175579   813 LALASNGALLAIGAENNLVK 832
Cdd:pfam20426  329 LAGTKDGSLLVYSIENPQLR 348
PTZ00420 PTZ00420
coronin; Provisional
 638-741 5.80e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  638 LKGHQDSVYSVSFSP-DGEILASTSRDRTVRLWHWRSGKT--------LAVLGGHTKSVDDAQFSP-DGQTLVSVCRDGQ 707
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPmNYYIMCSSGFDSF 149

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 499175579  708 IRLWDLDgNLIRQF--GLPEvAFFGVNWHPNGNLLA 741
Cdd:PTZ00420  150 VNIWDIE-NEKRAFqiNMPK-KLSSLKWNIKGNLLS 183
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 558-722 6.76e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.08  E-value: 6.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  558 GHRDG----VTSVAISSHKNLIAsASRDG-TVHLWTPQGEFLREFTGHTGSI------YRVDFSPNGKIFATAGQDQTVK 626
Cdd:cd14954    64 GSRDGqfdrPAGVAVNSRGRIIV-ADKDNhRIQVFDLNGRFLLKFGERGTKNgqfnypWGVAVDSEGRIYVSDTRNHRVQ 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  627 IWDLDGNLLQT------LKGHQDSVYSVSFSPDGEILASTSRDRTVRLWHwRSGKTLAVLGghTKSVDDAQFS------- 693
Cdd:cd14954   143 VFDSDGQFIRKfgfegaGPGQLDSPRGVAVNPDGNIVVSDFNNHRLQVFD-PDGQFLRFFG--SEGSGNGQFKrprgvav 219

                         170       180       190
                  ....*....|....*....|....*....|
gi 499175579  694 -PDGQTLVSVCRDGQIRLWDLDGNLIRQFG 722
Cdd:cd14954   220 dDEGNIIVADSGNHRVQVFSPDGEFLCSFG 249
WD40 pfam00400
WD domain, G-beta repeat;
756-794 7.44e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 7.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579   756 GEIKATLSGHDEFVTRVVFTPDGKQLFSSSSNGSVIHWS 794
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 564-747 1.03e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.44  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  564 TSVAISSHKNLIASASRDGTVHLWTPQGEFLREFtGHTGSIyRVDFSP------NGKIFATAGQDQTVKIWDLDGNLLQT 637
Cdd:cd14963    59 YGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYF-PEKKDR-VKLISPaglaidDGKLYVSDVKKHKVIVFDLEGKLLLE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  638 L------KGHQDSVYSVSFSPDGEILASTSRDRTVRLWHwRSGKTLAVLGGhtKSVDDAQFS--------PDGQTLVSVC 703
Cdd:cd14963   137 FgkpgsePGELSYPNGIAVDEDGNIYVADSGNGRIQVFD-KNGKFIKELNG--SPDGKSGFVnprgiavdPDGNLYVVDN 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 499175579  704 RDGQIRLWDLDGNLIRQFGLPEVAFFGVNwHPNGnlLAVaADDG 747
Cdd:cd14963   214 LSHRVYVFDEQGKELFTFGGRGKDDGQFN-LPNG--LFI-DDDG 253
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 584-804 1.64e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 48.04  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  584 VHLWTPQGEFLREFtGHTG-------SIYRVDFSPNGKIFATAGQDQTVKIWDLDGNLLQTLKGHQDSVYSVSFSPDGEI 656
Cdd:cd14961    34 IQVFDSDGNCLQQF-GPKGdagqdirYPLDVAVTPDGHIVVTDAGDRSVKVFSFDGRLKLFVRKSFSLPWGVAVNPSGEI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  657 LASTSRDRTvrLWHWRSGKTLAVLGGHTKsVDDAQFSPDGqtlVSVCRDG------------------QIRLWDLDGNLI 718
Cdd:cd14961   113 LVTDSEAGK--LFVLTVDFKLGILKKGQK-LCSQLCRPRF---VAVSRLGavavtehlfangtrssstRVKVFSSGGQLL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  719 RQ---FGLPEVAFF-----GVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEFVTR---VVFTPDGKQLFSSSSN 787
Cdd:cd14961   187 GQidsFGLNLVFPSlicasGVAFDSEGNVIVADTGSGAILCLGKPEGFPILKPIVTQGLSRpvgLAVTPDGSLVVLDSGN 266

                         250
                  ....*....|....*..
gi 499175579  788 GSVihwstsgkmlKKYQ 804
Cdd:cd14961   267 HCV----------KIYK 273
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 612-834 2.01e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.67  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  612 NGKIFATAGQDQTVKIWDLDGNLLQTLkGHQDSV-------YSVSFSPDGEILASTSRDRTVRLWHwRSGKTLAVLGGHT 684
Cdd:cd14963    19 DGRIYVADTNNHRVQVFDYEGKFKKSF-GGPGTGpgefkypYGIAVDSDGNIYVADLYNGRIQVFD-PDGKFLKYFPEKK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  685 KSVDDAQ----FSPDGQTLVSVCRDGQIRLWDLDGNLIRQFGLP---EVAFFGVN--WHPNGNLLAVaADDGTVRL--WT 753
Cdd:cd14963    97 DRVKLISpaglAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsePGELSYPNgiAVDEDGNIYV-ADSGNGRIqvFD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  754 PQGEIKATLSGHDEFVTR------VVFTPDGKQLFSSSSNGSVIHWSTSGKMLKKYQG---------YPEaifGLALASN 818
Cdd:cd14963   176 KNGKFIKELNGSPDGKSGfvnprgIAVDPDGNLYVVDNLSHRVYVFDEQGKELFTFGGrgkddgqfnLPN---GLFIDDD 252

                         250
                  ....*....|....*.
gi 499175579  819 GALLAIGAENNLVKVW 834
Cdd:cd14963   253 GRLYVTDRENNRVAVY 268
WD40 pfam00400
WD domain, G-beta repeat;
1028-1066 2.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 499175579  1028 GTLIRSIVAHGDRLNQLQYSPNGKYLLSAGREGTAKIWS 1066
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 705-751 3.88e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 3.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 499175579   705 DGQIRLWDLDGNLIRQFGLPE--VAFFGVNWHPNGNLLAVAADDGTVRL 751
Cdd:pfam12894   16 DGELLLHRLNWQRVWTLSPDKedLEVTSLAWRPDGKLLAVGYSDGTVRL 64
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 714-752 4.09e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.09e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 499175579    714 DGNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLW 752
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
676-835 5.19e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  676 TLAVLGGHTKSVDDAQFSPDGQTL-VSVCRDGQIRLWDL-DGNLIRQFGLPEVAFfGVNWHPNGNLLAVAA-DDGTVRLW 752
Cdd:COG3391    59 GLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLaTGKVVATIPVGGGPR-GLAVDPDGGRLYVADsGNGRVSVI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  753 -TPQGEIKATLSGHDEfVTRVVFTPDGKQLFSSSSNGSVIHW------STSGKMLKKYqGYPEAIFGLALASNGALLAI- 824
Cdd:COG3391   138 dTATGKVVATIPVGAG-PHGIAVDPDGKRLYVANSGSNTVSVivsvidTATGKVVATI-PVGGGPVGVAVSPDGRRLYVa 215

                         170
                  ....*....|....*...
gi 499175579  825 -------GAENNLVKVWD 835
Cdd:COG3391   216 nrgsntsNGGSNTVSVID 233
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 692-798 7.72e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.65  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  692 FSPDGQTLVSVCRDGQIRLWDLDGNLIRQFGLPEVAFFGVNWHPNGNLLAVAADDGTVRLWTPQGEIKATLSGHDEFVTR 771
Cdd:COG3386    15 WDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLADEYGKPLNR 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 499175579  772 ---VVFTPDGKQLFSSSS----NGSVIHWSTSGK 798
Cdd:COG3386    95 pndGVVDPDGRLYFTDMGeylpTGALYRVDPDGS 128
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 607-834 8.90e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 8.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  607 VDFSPNGKIFATAGQDQTVKIWDLDGNLLQTLKGHQDSVYSVSFSPDGEI---------LASTSRDRTVRLWHWRSGKTL 677
Cdd:PLN00181  489 IGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGIcwnsyiksqVASSNFEGVVQVWDVARSQLV 568

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  678 AVLGGHTKSVDDAQF-SPDGQTLVSVCRDGQIRLWDLD-----GNLIRQFGLPEVAFfgvnwhPN--GNLLAVAADDGTV 749
Cdd:PLN00181  569 TEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINqgvsiGTIKTKANICCVQF------PSesGRSLAFGSADHKV 642

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  750 ---RLWTPQGEIkATLSGHDEFVTRVVFTpDGKQLFSSSSNGSVIHW----STSG---KMLKKYQGYPEAIFGLALASNG 819
Cdd:PLN00181  643 yyyDLRNPKLPL-CTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWdlsmSISGineTPLHSFMGHTNVKNFVGLSVSD 720

                         250
                  ....*....|....*
gi 499175579  820 ALLAIGAENNLVKVW 834
Cdd:PLN00181  721 GYIATGSETNEVFVY 735
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 694-820 1.14e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 45.34  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  694 PDGQTLVSVCRDGQIRLWDLDGNLIRQFGLPEVAFF------GVNWHPNGNLLAVAADDGTVRLWTPQGEIKatLSGHDE 767
Cdd:cd14961    20 PTGRVVVADDGNKRIQVFDSDGNCLQQFGPKGDAGQdiryplDVAVTPDGHIVVTDAGDRSVKVFSFDGRLK--LFVRKS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  768 FV--TRVVFTPDGKQLFSSSSNGSVIHWSTSGKM--LKKYQGYPEAIF---GLALASNGA 820
Cdd:cd14961    98 FSlpWGVAVNPSGEILVTDSEAGKLFVLTVDFKLgiLKKGQKLCSQLCrprFVAVSRLGA 157
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 684-835 1.47e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  684 TKSVDDAQF--------SPDGQTLVSVCRDGQIRLWDLDGNLIRQFG----------LPEvaffGVNWHPNGNLLAVAAD 745
Cdd:cd14956     4 GRGSGPGQFkdprgiavDADDNVYVADARNGRIQVFDKDGTFLRRFGttgdgpgqfgRPR----GLAVDKDGWLYVADYW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  746 DGTVRLWTPQGEIKAT--LSGHDE----FVTRVVFTPDGKQLFSSSSNGSVIHWSTSGKMLKKYQGYPEAI------FGL 813
Cdd:cd14956    80 GDRIQVFTLTGELQTIggSSGSGPgqfnAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQWGGTGIEPgsfnypRGV 159

                         170       180
                  ....*....|....*....|..
gi 499175579  814 ALASNGALLAIGAENNLVKVWD 835
Cdd:cd14956   160 AVDPDGTLYVADTYNDRIQVFD 181
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
598-749 2.45e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  598 TGHTGSIYRVDFSPNGK-IFATAGQDQTVKIWDL-DGNLLQTLKGHQDSvYSVSFSPDG-EILASTSRDRTVRLWHWRSG 674
Cdd:COG3391    64 AAAVADADGADAGADGRrLYVANSGSGRVSVIDLaTGKVVATIPVGGGP-RGLAVDPDGgRLYVADSGNGRVSVIDTATG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  675 KTLAVLGGHtKSVDDAQFSPDGQTLVSVCRDGQ-----IRLWDL-DGNLIRQFGLPEVAfFGVNWHPNGNLLAVA-ADDG 747
Cdd:COG3391   143 KVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTaTGKVVATIPVGGGP-VGVAVSPDGRRLYVAnRGSN 220


                  ..
gi 499175579  748 TV 749
Cdd:COG3391   221 TS 222
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 1014-1106 2.52e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.74  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1014 AGDEQGNLTLW--NFDGTLIRSIVAHGDRLNQLQYSPNGKYLL-SAGREGTAKIW--SVEGQLLHTLKSDPLPIDQIAIS 1088
Cdd:COG0823     4 TLSRDGNSDIYvvDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGEPRRLTFGGGYNASPSWS 83

                          90
                  ....*....|....*....
gi 499175579 1089 PDSQWIA-TAASDGMVRLW 1106
Cdd:COG0823    84 PDGKRLAfVSRSDGRFDIY 102
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 566-721 4.63e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 43.69  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  566 VAISSHKNLIASASRDGTVHLWTPQGEFLREF------TGHTGSIYRVDFSPNGKIFATAGQDQTVKIWDLDGNLLQTLk 639
Cdd:cd14954   123 VAVDSEGRIYVSDTRNHRVQVFDSDGQFIRKFgfegagPGQLDSPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLRFF- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  640 GHQDSV-------YSVSFSPDGEILASTSRDRTVRLWHwRSGKTLAVLGGHtkSVDDAQFS-PDGqtlVSVCRDGQIRLW 711
Cdd:cd14954   202 GSEGSGngqfkrpRGVAVDDEGNIIVADSGNHRVQVFS-PDGEFLCSFGTE--GNGEGQFDrPSG---VAVTPDGRIVVV 275

                         170
                  ....*....|
gi 499175579  712 DLDGNLIRQF 721
Cdd:cd14954   276 DRGNHRIQVF 285
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
609-784 7.59e-04

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 43.36  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  609 FSPNGK-IFATAGQDQ----TVKIWDLDGNLlqTLKGHQDS-----VYsVSFSPDGEILASTS----------------- 661
Cdd:COG2706    52 LSPDGRfLYAVNEVDDggvsAFRIDPADGTL--TLLNTVSSggaspCH-LSVDPDGRFLFVANygggsvsvfpidadgsl 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  662 RDRTVRLWHWRSGKTLAVLGG-HTKSVddaQFSPDGQTLVSVC--RDgQIRLWDLDGNlirQFGLPEVAFFGVN------ 732
Cdd:COG2706   129 GEPVQVIQHEGSGPNPERQEGpHAHSV---VFDPDGRFLYVPDlgTD-RIYVYRLDPA---TGKLPEPPEVSLPpgsgpr 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  733 ---WHPNGNLLAVA-------------ADDGTvrlWTPQGEIKATLSGHDEFVT--RVVFTPDGKQLFSS 784
Cdd:COG2706   202 hlaFHPNGRFAYVIneldstvsvyaydAATGT---LTLIQTVSTLPEDFTGENWaaDIHISPDGRFLYVS 268
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 733-810 8.17e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 8.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   733 WHPNGNLLAVAADDGTV--------RLWTpqgeikATLSGHDEFVTRVVFTPDGKQLFSSSSNGSV-IHWSTSGKMLKKY 803
Cdd:pfam12894    3 WCPTMDLIALATEDGELllhrlnwqRVWT------LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVrLLDAENGKIVHHF 76


                   ....*..
gi 499175579   804 QGYPEAI 810
Cdd:pfam12894   77 SAGSDLI 83
GSDH pfam07995
Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases ...
 692-788 8.53e-04

Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.


Pssm-ID: 429776 [Multi-domain]  Cd Length: 327  Bit Score: 42.93  E-value: 8.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579   692 FSPDGQTLVSVcRDGQIRLWDLDGNLIRQ-FGLPEVAFFGvnwhpNGNLLAVA-----ADDGTVRL-WTPQGE------- 757
Cdd:pfam07995    9 FLPDGRMLVTE-RPGRLRIVDADGKLSTPiAGVPEVAARG-----QGGLLDVAlhpdfAENRWVYLsYAEAGGggagtav 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 499175579   758 IKATLSGHD---EFVT-----------------RVVFTPDGKQLFSSSSNG 788
Cdd:pfam07995   83 ARARLSDDGtalEDVEvifrqipkvsggghfgsRLVFGPDGTLFVTTGDRG 133
WD40 pfam00400
WD domain, G-beta repeat;
730-752 1.32e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|...
gi 499175579   730 GVNWHPNGNLLAVAADDGTVRLW 752
Cdd:pfam00400   16 SLAFSPDGKLLASGSDDGTVKVW 38
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 739-1077 1.91e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  739 LLAVAADDGTVRLWTP-QGEIKAT---------LSGHDEFVTrvVFTPDGkQLFSSSSNGSVIHW-----STSGKMLKKY 803
Cdd:cd22857    46 LLAVARKNGTVEVLDPeNGDLLASfsdsepatkLSEEDHFVG--LHLFSG-TLLTCTSKGSLRSTklpddSTASSSPTAW 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  804 QGYPEAIFGLALASNGALLAIGAENNLVKVWDMSPKsdlvnlnlpavlgavaenaktntialamenePLILFNTKNRSRQ 883
Cdd:cd22857   123 VCLGGNLLCMRVDPNENYFAFGGKEVELNVWDLEEK-------------------------------PGKIWRAKNVPND 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  884 FLsdasqnldrlkfsadgqwllgqrgrqwqlwQLQTksqllKTWRTDISRVYDVDLRTtptspqwaIAMATGSGEVQLWq 963
Cdd:cd22857   172 SL------------------------------GLRV-----PVWVTDLTFLSKDDHRK--------IVTGTGYHQVRLY- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579  964 gtknnQTSGNQSqgvpielndPIVlalgnSIQ-RKEPIRSVSLHPTLPQLAAGDEQGNltLWNFD--------------G 1028
Cdd:cd22857   208 -----DTRAQRR---------PVV-----SVDfGETPIKAVAEDPDGHTVYVGDTSGD--LASIDlrtgkllgcfkgkcG 266

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499175579 1029 TLIRSIVAHgdrlnqlqysPNGKYLLSAGREGTAKIWSVE-GQLLH--TLKS 1077
Cdd:cd22857   267 GSIRSIARH----------PELPLIASCGLDRYLRIWDTEtRQLLSkvYLKQ 308
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 1016-1113 8.85e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.11  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499175579 1016 DEQGNLTLW--NFDGTLIRSIVAHGDRLNQLQYSPNGKYLL-SAGREGTAKIW--SVEGQLLHTLKSDPLpidQIAISPD 1090
Cdd:COG0823    50 DRGGGPQIYvvDADGGEPRRLTFGGGYNASPSWSPDGKRLAfVSRSDGRFDIYvlDLDGGAPRRLTDGPG---SPSWSPD 126

                          90       100
                  ....*....|....*....|....*.
gi 499175579 1091 SQWIA-TAASDGMVRLW--DQQGNLR 1113
Cdd:COG0823   127 GRRIVfSSDRGGRPDLYvvDLDGRKR 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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