|
Name |
Accession |
Description |
Interval |
E-value |
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
6-708 |
0e+00 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 1179.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 6 LRSKFILLSCFLFLLPWLGYEYVWEMEKFLRQGQEKTLVGTTRALATALHERPALFDQQTSFLDQVVKGRDLYAYNLKNP 85
Cdd:TIGR03785 1 LRRKLLLLSLFLLLLPWAGYQYVWEMEKYLRQGQEQTLVGTARALATALHERPALFDTQASFLGQVKGGRDLYAYPLDTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 86 IQLDGKLTDWESYQALFWQYDKrylQKTDNKHQASDLSFEHMVGKFDNYLYALFKVTDNQLVYRPKNSLSITNNDHLKIG 165
Cdd:TIGR03785 81 IYLDGYLDDWPEYQHRFQQYGQ---LQTAGKPKPLSLSFTHMVGKYDQYLYLLFQVTDNRLQYRGPNARSIQNNDHLEIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 166 LKTPDGQFNRYIIAPRQDGWVNAFNADS---KVPFTKIQGYFSSTAAGYNIELRFPISMLGNKLGFAIIDVDNKEPLLEP 242
Cdd:TIGR03785 158 LLAPDGQFQRYIVATEQPGWISAFRLPEnprKAPEHRIQGHWLETGAGYNIELRLPLAMLGSKLGFAITDVDDSKARVIN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 243 KIMSTSNLNNPSDLGSVLVPSPEINRILKGMGHSGSRIWVVDKHHRVLAQSGSIHHADGVWADGLANQAPETWWQQFEQN 322
Cdd:TIGR03785 238 AIIGTRNGNDVEKLGTVLVPSPEIENILKGMSHTGSRIWVVDQHARVLASSGDLNSSIGVWAKTLKEQHPDSWWQQFEQQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 323 YLHPLYYKILTRPENEFLDTLHDVAAMQGSHLAKALKGQPASSWRLTPDSKAVILSAAYPIWIQDKVIGAVIAEETTNGV 402
Cdd:TIGR03785 318 YLHPLYYKILTKPPADFIDQLQDSQALEGSHIIKALQGQPASTWRLSPDSKAVILSAAYPIWIDTEVLGAVIAEQTTNGI 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 403 RTLRNKSLEKLFNVILAVMLIGTVTLFFFASRISSRIRRLRDTAEQAIDAQGRVTGSINYSDANDEIGDLSRSFANIVSR 482
Cdd:TIGR03785 398 RTLRNSALEKLFNVILAIMSIGTLALFGFASWISWRIRRLSDDAEAAIDSQGRISGAIPASRSRDEIGDLSRSFAQMVAR 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 483 LGGYTNYLENMSSRLSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEP 562
Cdd:TIGR03785 478 LRQYTHYLENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVED 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 563 FDLQKVISGCMQGYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNY 642
Cdd:TIGR03785 558 FDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNE 637
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499646591 643 GPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNQQGDGVVFTVSLP 708
Cdd:TIGR03785 638 GPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNDGVVFRISLP 703
|
|
| CBM9_like_HisKa |
cd09622 |
DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine ... |
6-297 |
1.40e-86 |
|
DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this family are located at the N-terminus of bacterial sensor histidine kinases and may constitute or contribute to the ligand-binding moiety.
Pssm-ID: 187680 Cd Length: 265 Bit Score: 273.11 E-value: 1.40e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 6 LRSKFILLSCFLFLLPWLGYEYVWEMEKFLRQGQEKTLvgttralatalherpalfdQQTSFLDQVVKGRDLYAYNLKNP 85
Cdd:cd09622 3 LTRQLLAVSLLMLLLPWAGCQFLKELEQALRQQQSQQL-------------------QQQGNRLAALAGTDLYAYPLAGA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 86 IQLDGKLTDWESYQALFWQYDkrylqktdNKHQASDLSFEHMVGKFDNYLYALFKVTDNQLVYRPKNSLSITNNDHLKIG 165
Cdd:cd09622 64 ILLDGYADDWPGYDSAFQLEG--------EAGQASSLAFKHRAGKYDRYLYLLFQVSDNTVIYRFNPSLPEDAHDHLLLQ 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 166 LKTPDGQFNRYIIAPRQDGWVNAFN--ADSKVPFTKIQGYFSSTAAGYNIELRFPISMLGNKLGFAIIDVDNKepllEPK 243
Cdd:cd09622 136 TEDPNGQRQRYLIATSAPGWVNAFRltRNAGAPEYRIQGHWQETADGYQLELRLPLSLVGSRLGFALTDVDNS----NNR 211
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 499646591 244 IMSTSNLNNPSDLGSVLVPSPEINRILKGMGHSGSRIWVVDKHHRVLAQSGSIH 297
Cdd:cd09622 212 IIGTANPLTLIPLPTLVVPSPELERILAGMSRPGSRLWVLDSHGWVLARQGDIQ 265
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
491-711 |
3.64e-44 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 158.53 E-value: 3.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 491 ENMSSRLSHELRTPVAVVRSSLENLQMQPQ--SELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKV 568
Cdd:COG2205 17 SEFLANVSHELRTPLTSILGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAEL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 569 ISGCMQGYQLTYPKQL--FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLL 646
Cdd:COG2205 97 LEEAVEELRPLAEEKGirLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGI 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499646591 647 PVGLTEHIFDSMvsVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNqQGDGVVFTVSLPLVK 711
Cdd:COG2205 177 PEEELERIFERF--YRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESE-PGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
490-709 |
6.50e-42 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 155.45 E-value: 6.50e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMSSRLSHELRTPVAVVRSSLENLQMQPQSELsQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVI 569
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEEQ-REYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 570 SGCMQGYQLTYP-KQL-FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLP 647
Cdd:COG0642 189 EEVVELFRPLAEeKGIeLELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIP 268
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499646591 648 VGLTEHIFDSMVSVRSQqmQQQPHLGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPL 709
Cdd:COG0642 269 PEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVE-SEPGKGTTFTVTLPL 327
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
490-711 |
1.25e-41 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 156.25 E-value: 1.25e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMSSRL----SHELRTPVAVVRSSLENLQMQPQ--SELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPF 563
Cdd:COG5002 161 LEQMRREFvanvSHELRTPLTSIRGYLELLLDGAAddPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPV 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 564 DLQKVISGCMQGYQLTYPKQL--FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGN 641
Cdd:COG5002 241 DLAELLEEVVEELRPLAEEKGieLELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRD 320
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 642 YGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPLVK 711
Cdd:COG5002 321 TGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVE-SEPGKGTTFTITLPLAR 389
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
493-711 |
1.16e-25 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 110.44 E-value: 1.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 493 MSSRLSHELRTPVAVVRSSLENLQMQPQSELS------QKYLDRASEGVERLGKIITTMSEATRLEQSiqsnEPEPFDLQ 566
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredlERALDTIIRQVDRLKRIVDEFLDFARLPEP----QLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 567 KVISGCMQGYQLTYPKQL--FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGP 644
Cdd:COG5000 280 ELLREVLALYEPALKEKDirLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499646591 645 LLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPLVK 711
Cdd:COG5000 360 GIPEEVLERIFEPFFTTKPKGT------GLGLAIVKKIVEEHGGTIELESRPGG-GTTFTIRLPLAE 419
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
358-709 |
3.47e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.47 E-value: 3.47e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 358 LKGQ-PASSWRLTPD--SKAVILSAAyPIWIQDKVIGAVIAEETTNGVRTLRNKSLEKLFN----VILAVMLIGT-VTLF 429
Cdd:PRK11100 127 LRGEyGARSTREDPAdpESSVMYVAA-PIRDGGRIIGVLSVGKPNSSMAPFIKRSERRILWagalLLGIALLIGAgVVWW 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 430 FFasrissrirrlrdtaeQAIdaqGRVTgsiNYSDA-------------NDEIGDLSRSFANIVSRLGGyTNYLENMSSR 496
Cdd:PRK11100 206 LN----------------RSI---RRLT---RYADAvtegkpvplpklgSSELRELAQALESMRVKLEG-KAYVEQYVQT 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGCMQGY 576
Cdd:PRK11100 263 LTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 577 QLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFD 656
Cdd:PRK11100 343 EAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFE 422
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 499646591 657 SMVSVrsqqmqQQPH-----LGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPL 709
Cdd:PRK11100 423 RFYSL------PRPAngrksTGLGLAFVREVARLHGGEVTLRNRPEG-GVLATLTLPR 473
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
493-710 |
3.10e-22 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 99.10 E-value: 3.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 493 MSSRLSHELRTPVAVVRSSLENLQM----QPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSiqsnEPEPFDLQKV 568
Cdd:COG4191 145 LAAGIAHEINNPLAAILGNAELLRRrledEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNEL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 569 ISGCMQ--GYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIE-FSHAEKP-ISVSLKQNDSAAILTVGNYGP 644
Cdd:COG4191 221 IDEALEllRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDaMEEGEGGrITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499646591 645 LLPVGLTEHIFDSMVSVRSQQMQqqphLGLGLYIVR-LVCDyHNASVTAKNNqQGDGVVFTVSLPLV 710
Cdd:COG4191 301 GIPPEVLERIFEPFFTTKPVGKG----TGLGLSISYgIVEK-HGGRIEVESE-PGGGTTFTITLPLA 361
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
603-707 |
8.35e-20 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 84.96 E-value: 8.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 603 IAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMqqQPHLGLGLYIVRLV 682
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....*
gi 499646591 683 CDYHNASVTAKNNQQGdGVVFTVSL 707
Cdd:cd00075 79 VEAHGGRITVESEPGG-GTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
598-709 |
8.68e-20 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 85.01 E-value: 8.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 598 GAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVrSQQMQQQPHLGLGLY 677
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-DKRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 499646591 678 IVRLVCDYHNASVTAkNNQQGDGVVFTVSLPL 709
Cdd:smart00387 80 IVKKLVELHGGEISV-ESEPGGGTTFTITLPL 110
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
490-708 |
2.82e-19 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 91.77 E-value: 2.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMSSRLSHELRTPVAVVRSSLENLQMQPQSELS---QKYLDRASEGVERLGKIITTMSEATRLEQsiQSNEPEPFDLQ 566
Cdd:COG4251 282 LEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDeegREYLERIRDAAERMQALIDDLLAYSRVGR--QELEFEPVDLN 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 567 KVISGCMQGYQLTYPKQLFTLDIcqTALPM-QGAPEFIAQLLDKLINNAIEFSHAEKP--ISVSLKQNDSAAILTVGNYG 643
Cdd:COG4251 360 ELLEEVLEDLEPRIEERGAEIEV--GPLPTvRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNG 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499646591 644 PLLPVGLTEHIFDsmVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLP 708
Cdd:COG4251 438 IGIDPEYAEKIFE--IFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVE-SEPGEGATFYFTLP 499
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
460-708 |
5.48e-18 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 87.44 E-value: 5.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 460 INYSDANDEIGDLSRSFANIVSRL-GGYTNyLENMSSRLSHELRTPvavvrssLENLQMQPQSELSQ-----KY---LDR 530
Cdd:TIGR01386 211 LDPSRAPAELRELAQSFNAMLGRLeDAFQR-LSQFSADLAHELRTP-------LTNLLGQTQVALSQprtgeEYrevLES 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 531 ASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGCMQGYQLTYPKQLFTLDICQTALpMQGAPEFIAQLLDKL 610
Cdd:TIGR01386 283 NLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGL-VRGDPQMFRRAISNL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 611 INNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASV 690
Cdd:TIGR01386 362 LSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRA 441
|
250
....*....|....*...
gi 499646591 691 TAknNQQGDGVVFTVSLP 708
Cdd:TIGR01386 442 SA--ESPDGKTRFILRFP 457
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
497-709 |
9.62e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 76.95 E-value: 9.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTPVAVVRSSLE---NLqmqpqSELSQKYLDRaseGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGCM 573
Cdd:PRK10604 219 IAHELRTPLVRLRYRLEmsdNL-----SAAESQALNR---DIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 574 QGYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEfsHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEH 653
Cdd:PRK10604 291 ADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALR--YAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERER 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 499646591 654 IFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPL 709
Cdd:PRK10604 369 VFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELG-GARFSFSWPV 423
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
598-709 |
2.08e-14 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 69.70 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 598 GAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDsAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQphlGLGLY 677
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGT---GLGLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 499646591 678 IVRLVCDYHNASVTAKNNQQGdGVVFTVSLPL 709
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGG-GTTVTLTLPL 107
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
382-708 |
3.37e-14 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 75.63 E-value: 3.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 382 PIWIQDKVIGAVIAEETTngvRTLRNKSLEKLFNVILAVMLIGTVTLFFFASRISSRIRRLRDTAEQAIDAQGRVTGSiN 461
Cdd:NF012163 131 PILVNGQEVGALGASPVE---RLTRNTDINFDSQQKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAG-D 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 462 YS-----DANDEIGDLSRSFANIVSRLGGYTNYLENMSSRLSHELRTPVAVVRSSLENLQmQPQSELSQKYLDRASEGVE 536
Cdd:NF012163 207 YTtrvtpTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQ-DGIRKFTPESLDSLQAEVG 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 537 RLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGCMQGYQLTYPKQLFTLDICQTALPMQ-GAPEFIAQLLDKLINNAI 615
Cdd:NF012163 286 TLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVfGDRDRLMQLFNNLLENSL 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 616 EFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNN 695
Cdd:NF012163 366 RYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHS 445
|
330
....*....|...
gi 499646591 696 QQGdGVVFTVSLP 708
Cdd:NF012163 446 PLG-GLRIVVTLP 457
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
493-711 |
8.72e-14 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 73.34 E-value: 8.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 493 MSSRLSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSiqsnEPEPFDLQKVISGC 572
Cdd:COG3852 138 LAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPP----EREPVNLHEVLERV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 573 MQGYQLTYPKQL-FTLDICQTALPMQGAPEFIAQLLDKLINNAIE----------FSHAEKPISVSLKQNDSAAILTVGN 641
Cdd:COG3852 214 LELLRAEAPKNIrIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEampeggtitiRTRVERQVTLGGLRPRLYVRIEVID 293
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 642 YGPLLPVGLTEHIFDSMVSVRSQqmqqqpHLGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPLVK 711
Cdd:COG3852 294 NGPGIPEEILDRIFEPFFTTKEK------GTGLGLAIVQKIVEQHGGTIEVE-SEPGKGTTFRIYLPLEQ 356
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
490-707 |
1.42e-13 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 72.63 E-value: 1.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMS----SRLSHELRTPVAVVRSSLENLQ--MQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPF 563
Cdd:TIGR02966 110 LEQMRrdfvANVSHELRTPLTVLRGYLETLAdgPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPV 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 564 DLQKVISG-CMQGYQLTYPKQL-FTLDIcQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGN 641
Cdd:TIGR02966 190 DMPALLDHlRDEAEALSQGKNHqITFEI-DGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTD 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499646591 642 YGPLLPvglTEHI------FDSMVSVRSQQMQQQphlGLGLYIVRLVCDYHNASVTAkNNQQGDGVVFTVSL 707
Cdd:TIGR02966 269 TGIGIA---PEHLprlterFYRVDKSRSRDTGGT---GLGLAIVKHVLSRHHARLEI-ESELGKGSTFSFIF 333
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
603-709 |
1.59e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 67.07 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 603 IAQLLDKLINNAIEfsHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLV 682
Cdd:cd16939 1 MARALDNLLRNALR--YAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*..
gi 499646591 683 CDYHNASVTAKNNQQGdGVVFTVSLPL 709
Cdd:cd16939 79 ALWHGGHVECDDSELG-GACFRLTWPR 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
472-709 |
8.47e-13 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 71.99 E-value: 8.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 472 LSRSFANivSRLGGYTNYLEN-MSSRLSHELRTPVAVVRSSLENLQMQPQSELSqKYLDRASEGVErlgKIITTmseaTR 550
Cdd:PRK10490 647 LTASEEQ--ARLASEREQLRNaLLAALSHDLRTPLTVLFGQAEILTLDLASEGS-PHARQASEIRQ---QVLNT----TR 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 551 LEQS------IQSN----EPEPFDLQKVISGCMQGYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHA 620
Cdd:PRK10490 717 LVNNlldmarIQSGgfnlRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGA 796
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 621 EKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMvsVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNQQGdG 700
Cdd:PRK10490 797 QAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF--ARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEG-G 873
|
....*....
gi 499646591 701 VVFTVSLPL 709
Cdd:PRK10490 874 ACFRVTLPL 882
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
399-711 |
1.15e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 70.26 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 399 TNGVRTLRNKSLEKLFNVILAVMLIGTVTLFFFASRISSRIRRLRDTA----EQAIDAQGRVTGSINYSDANDEIGDLSR 474
Cdd:COG3290 102 RDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERDEEILLNGRVlvvnRVPIRDDGRVVGAVATFRDRTELERLEE 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 475 sfanivsRLGGYTNYLENMSSrLSHELRTPVAVVRSSLENLQMQpqsELsQKYLDRASEGVERLGKIITtmseatrleqs 554
Cdd:COG3290 182 -------ELEGVKELAEALRA-QRHDFRNHLHTISGLLQLGEYD---EA-LEYIDEISEELQELIDSLL----------- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 555 IQSNEPepfdlqkVISGCMQGYqLTYPKQL---FTLDIcQTALPMQGAPEF-IAQLLDKLINNAIE----FSHAEKPISV 626
Cdd:COG3290 239 SRIGNP-------VLAALLLGK-AARARERgidLTIDI-DSDLPDLPLSDTdLVTILGNLLDNAIEavekLPEEERRVEL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 627 SLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSvrsqqMQQQPHLGLGLYIVRLVCDYHNASVTAKNNqQGDGVVFTVS 706
Cdd:COG3290 310 SIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESE-EGEGTVFTVR 383
|
....*
gi 499646591 707 LPLVK 711
Cdd:COG3290 384 LPKEG 388
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
490-553 |
1.23e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.30 E-value: 1.23e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499646591 490 LENMSSRLSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQ 553
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
467-710 |
2.94e-11 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 66.59 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 467 DEIGDLSRSFANIVSRLGGYTNYLENMS-------SRLSHELRTPVAVVRSSLENL-----QMQPQSELSQKYLDRAseg 534
Cdd:NF040691 241 DDLARLARSFNQMADSLQRQIRQLEELSrlqqrfvSDVSHELRTPLTTIRMAADVIhdsrdDFDPATARSAELLHTE--- 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 535 VERLGKIITTMSEATRLEQSIQSNEPEPFDL----QKVISGCMQ-----GYQLtypkqlfTLDICQTALPMQGAPEFIAQ 605
Cdd:NF040691 318 LDRFESLLSDLLEISRFDAGAAELDVEPVDLrplvRRVVDALRQlaeraGVEL-------RVDAPGTPVVAEVDPRRVER 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 606 LLDKLINNAIEfsHAE-KPISVSLKQNDSAAILTVGNYGpllpVGLT----EHIFDSMVSVRSQQMQQQPHLGLGLYIVR 680
Cdd:NF040691 391 VLRNLVVNAIE--HGEgKPVVVTVAQDDTAVAVTVRDHG----VGLKpgevALVFDRFWRADPARARTTGGTGLGLAIAL 464
|
250 260 270
....*....|....*....|....*....|
gi 499646591 681 LVCDYHNASVTAKnNQQGDGVVFTVSLPLV 710
Cdd:NF040691 465 EDARLHGGWLEAW-GRPGQGSQFRLTLPRV 493
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
467-708 |
4.58e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 64.99 E-value: 4.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 467 DEIGDLSRSFANIVSRLggyTNYLEN---MSSRLSHELRTPVAVVRSSLENLQMQPQSELSQ--KYLDRASEGVERLgki 541
Cdd:PRK10755 114 LEIEAVTSALNQLVSRL---TSTLDQerlFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPliARLDQMMHTVEQL--- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 542 iTTMSeatRLEQSIQSNEPEPFDLQKVISGCMQ---GYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFS 618
Cdd:PRK10755 188 -LQLA---RAGQSFSSGHYQTVKLLEDVILPSQdelSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYS 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 619 HAEKPISVSLKQNDSAAILTVGNYGPllpvGLTEhifdSMVSVRSQQ---MQQQ-PHLGLGLYIVRLVCDYHNASVTAKN 694
Cdd:PRK10755 264 PEGSTITIKLSQEDGGAVLAVEDEGP----GIDE----SKCGELSKAfvrMDSRyGGIGLGLSIVSRITQLHHGQFFLQN 335
|
250
....*....|....
gi 499646591 695 NQQGDGVVFTVSLP 708
Cdd:PRK10755 336 RQERSGTRAWVWLP 349
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
490-553 |
9.80e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.96 E-value: 9.80e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499646591 490 LENMSSRLSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQ 553
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
499-711 |
1.13e-10 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 64.60 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 499 HELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSiqsnEPEPFDLQKVISGCMQGYQL 578
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRES----QWQPVSLNALVEEVLQLFQT 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 579 TYPKQLFTLDI-CQTALPMQGA-PEFIAQLLDKLINNAIEFSHAEKPISVSLKQ-NDSAAILTVGNYGPLLPVGLTEHIF 655
Cdd:PRK11360 475 AGVQARVDFETeLDNELPPIWAdPELLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKIF 554
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 499646591 656 DSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPLVK 711
Cdd:PRK11360 555 DPFFTTKAKGT------GLGLALSQRIINAHGGDIEVE-SEPGVGTTFTLYLPINP 603
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
497-709 |
3.39e-10 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 63.64 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGC---M 573
Cdd:TIGR02956 471 MSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVhhlM 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 574 Q------GYQLTYPkqlFTLDICQTalpMQGAPEFIAQLLDKLINNAIEFSH-AEKPISVSLkQNDSAAILTVGNYGpll 646
Cdd:TIGR02956 551 VsraqlkGIQLRLN---IPEQLPNW---WQGDGPRIRQVLINLVGNAIKFTDrGSVVLRVSL-NDDSSLLFEVEDTG--- 620
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499646591 647 pVGLTEHIFDSMVSVRSQ--QMQQQPHLGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPL 709
Cdd:TIGR02956 621 -CGIAEEEQATLFDAFTQadGRRRSGGTGLGLAISQRLVEAMDGELGVE-SELGVGSCFWFTLPL 683
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
603-708 |
3.83e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.58 E-value: 3.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 603 IAQLLDKLINNAIEFSHAEK-PISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRL 681
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 499646591 682 VCDYHNASVTAKNNQQGD---GVVFTVSLP 708
Cdd:cd16953 81 IIEAHGGISVAENHNQPGqviGARFTVQLP 110
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
468-708 |
5.59e-10 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 62.10 E-value: 5.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 468 EIGDLSRSFANIVSRLGGYTNYLENMSSRLSHELRTPVAvvrssleNLQMQPQSELSQKYLDRASEGV-----ERLGKII 542
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPIT-------NLITQTEIALSQSRSQKELEDVlysnlEELTRMA 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 543 TTMSEATRLEQSiQSNE--PE--PFDLQKVISGCMQGYQLTYPKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFS 618
Cdd:PRK09835 313 KMVSDMLFLAQA-DNNQliPEkkMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYT 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 619 HAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNqqG 698
Cdd:PRK09835 392 PAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD--A 469
|
250
....*....|
gi 499646591 699 DGVVFTVSLP 708
Cdd:PRK09835 470 RGTRFVISLP 479
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
455-709 |
2.04e-09 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 60.01 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 455 RVTGSINY-SDANDEI--GDLS---RSFANIVSRLGGYTNYLENMSSRL--------------SHELRTPVAVVRSSLEN 514
Cdd:NF012226 83 RFIVPINFlADAAKKIsqGDLSaraEDSQIHSAEISELMHNFNDMAQKLessvknaqvwnaaiAHELRTPITILQGRLQG 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 515 L---QMQPQSELSQKYLDRAsEGVERLGKIITTMS--EATRLEQSIqsnepEPFDLQKVISGCMQGYQLTYPKQLFTLDI 589
Cdd:NF012226 163 IldgVFEPDPALFKSLLNQV-EGLSHLVEDLRTLSlvENQQLRLNY-----ESVDLKDSIEKVLKMFEDRLEQAQLTIVL 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 590 CQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKpISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQ 669
Cdd:NF012226 237 NLTATPVFCDRRRIEQVLIALIDNAIRYANAGK-LKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEF 315
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 499646591 670 PHLGLGLYIVRLVCDYHNASVTAKNNQQGDgvVFTVSLPL 709
Cdd:NF012226 316 GGTGLGLAVVHAIVIAHKGSIEYSNSQGNS--VFTIKLPA 353
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
455-711 |
2.68e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 60.03 E-value: 2.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 455 RVTGSinysdANDEIGDLSRSFANIVSRLGgytnylENMSSR------LSHELRTPVAVVRSSLENLQmqpqselsqkyl 528
Cdd:PRK10549 210 RVTPT-----SRDELGRLAQDFNQLASTLE------KNEQMRrdfmadISHELRTPLAVLRGELEAIQ------------ 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 529 drasEGVERLG--KIITTMSEATRL-------EQSIQSNE------PEPFDLQKVISGCMQGYQLTYPKQLFTLDicqTA 593
Cdd:PRK10549 267 ----DGVRKFTpeSVASLQAEVGTLtklvddlHQLSLSDEgalayrKTPVDLVPLLEVAGGAFRERFASRGLTLQ---LS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 594 LPMQ----GAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQ 669
Cdd:PRK10549 340 LPDSatvfGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRAS 419
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 499646591 670 PHLGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPLVK 711
Cdd:PRK10549 420 GGSGLGLAICLNIVEAHNGRIIAAHSPFG-GVSITVELPLER 460
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
490-550 |
3.04e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 53.76 E-value: 3.04e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499646591 490 LENMSSRLSHELRTPVAVVRSSLENLQMQP-QSELSQKYLDRASEGVERLGKIITTMSEATR 550
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLEEELlDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
494-706 |
9.52e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 58.12 E-value: 9.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 494 SSRLSHELRTPVA-------VVRSSLENLQMQpQSELSQ--KYLDRASEGVERLgkiiTTMSeatRLEQSIQSNEPEPFD 564
Cdd:PRK10337 241 TSDAAHELRSPLAalkvqteVAQLSDDDPQAR-KKALLQlhAGIDRATRLVDQL----LTLS---RLDSLDNLQDVAEIP 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 565 LQKVI-SGCMQGYQLTYPKQL-FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLkqndSAAILTVGNY 642
Cdd:PRK10337 313 LEDLLqSAVMDIYHTAQQAGIdVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NARNFTVRDN 388
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499646591 643 GPllpvGLTEHIFDSmVSVRSQQM--QQQPHLGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVS 706
Cdd:PRK10337 389 GP----GVTPEALAR-IGERFYRPpgQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEG-GFEAKVS 448
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
603-709 |
1.27e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 53.10 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 603 IAQLLDKLINNAIEFSHAEkpISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLV 682
Cdd:cd16949 1 LARALENVLRNALRYSPSK--ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*..
gi 499646591 683 CDYHNASVTAKNNQQGdGVVFTVSLPL 709
Cdd:cd16949 79 IEQHGGKIKASNRKPG-GLRVRIWLPA 104
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
600-708 |
5.53e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 51.34 E-value: 5.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 600 PEFIAQLLDKLINNAIEFSHAEKPISVSLKQND-SAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYI 678
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSI 81
|
90 100 110
....*....|....*....|....*....|
gi 499646591 679 VRLVCDYHNASVTAkNNQQGDGVVFTVSLP 708
Cdd:cd16925 82 VKEFVELHGGTVTV-SDAPGGGALFQVELP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
600-698 |
6.18e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 51.31 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 600 PEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHlGLGLYIV 679
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKST-GLGLAFV 80
|
90
....*....|....*....
gi 499646591 680 RLVCDYHNASVTAKNNQQG 698
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDG 99
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
497-680 |
6.26e-08 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 55.34 E-value: 6.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTP-----VAVvrSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSeATRLEQSIQSNE-----PEPFDLQ 566
Cdd:PRK09303 158 LAHDLRTPltaasLAL--ETLELGQIDEDTELKPALIEQLQDQARRQLEEIERLI-TDLLEVGRTRWEalrfnPQKLDLG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 567 KVISGCMQGYQLTY--PKQLFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAI-LTVGNYG 643
Cdd:PRK09303 235 SLCQEVILELEKRWlaKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVqVSICDTG 314
|
170 180 190
....*....|....*....|....*....|....*..
gi 499646591 644 PLLPVGLTEHIFDSmvSVRSQQMQQQPHLGLGLYIVR 680
Cdd:PRK09303 315 PGIPEEEQERIFED--RVRLPRDEGTEGYGIGLSVCR 349
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
490-709 |
9.16e-07 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 52.10 E-value: 9.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMSSRLSHELRTPVavvrSSLENL------QMQPQSELSQKYLDRASEgVERLGKIITTMSEATRLEQSiqsnEPEPF 563
Cdd:PRK10364 237 LGHLAAGVAHEIRNPL----SSIKGLakyfaeRAPAGGEAHQLAQVMAKE-ADRLNRVVSELLELVKPTHL----ALQAV 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 564 DLQKVISGCMQ---------GYQLTypkqlFTLDICQTALPMQgaPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSA 634
Cdd:PRK10364 308 DLNDLINHSLQlvsqdansrEIQLR-----FTANDTLPEIQAD--PDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAG 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499646591 635 AILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAKNnQQGDGVVFTVSLPL 709
Cdd:PRK10364 381 VKISVTDSGKGIAADQLEAIFTPYFTTKAEGT------GLGLAVVHNIVEQHGGTIQVAS-QEGKGATFTLWLPV 448
|
|
| CBM9_like_4 |
cd09619 |
DOMON-like type 9 carbohydrate binding module; Family 9 carbohydrate-binding modules (CBM9) ... |
85-257 |
1.66e-06 |
|
DOMON-like type 9 carbohydrate binding module; Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this uncharacterized heterogeneous subfamily are often located at the C-terminus of longer proteins and may co-occur with various other domains.
Pssm-ID: 187677 Cd Length: 187 Bit Score: 48.97 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 85 PIQLDGKLTDWESYQALFWQYDKRYLQKTDNKhqASDLSFEHMVGKFDNYLYALFKVTDNQLvYRPKNSLSITNNDHLKI 164
Cdd:cd09619 1 APAIDGTLEAAWYPGSILPLEAKGLIDDTGPS--ATDLSATFAAMWDDTNLYVLVDVTDDTL-RNDLDGKDHWRGDAVEI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 165 GLKTPDGQFNRYIIAPRQDG---WVNAFNADSKVPFTKIQGY-FSSTAA--GYNIELRFPISMLGNK--------LGFAI 230
Cdd:cd09619 78 FIDPDGNKLATYTANDFQLGfrpNDETGQPEGWNHTTPAPGIrVASTPRygGYTVEAAIPWSTLGITpaanlllgFDVAI 157
|
170 180 190
....*....|....*....|....*....|
gi 499646591 231 IDVDNKEPLLEPKIMSTSNL---NNPSDLG 257
Cdd:cd09619 158 NDDDTGGTRDQQIAWNAKDDqnwSNPSLFG 187
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
597-707 |
3.22e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 46.63 E-value: 3.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 597 QGAPEFIAQLLDKLINNAIEFSHAEKPISVSLkQNDSAAILTVGNYGPLLPVGLTEHIFDSMVsvRSQQmQQQPHLGLGL 676
Cdd:cd16940 8 QGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFY--RSDG-QNYGGSGLGL 83
|
90 100 110
....*....|....*....|....*....|.
gi 499646591 677 YIVRLVCDYHNASVTAKNNQQGdGVVFTVSL 707
Cdd:cd16940 84 SIVKRIVELHGGQIFLGNAQGG-GLEAWVRL 113
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
498-710 |
6.32e-06 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 49.14 E-value: 6.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 498 SHELRTPVAVVRSSLEnlQMQPQSElsqkYLdraSEGV----ERLGKIITTMSEATRLEQSIQSnepEPFDLQKVISGCM 573
Cdd:PRK09467 237 SHDLRTPLTRIRLATE--MMSEEDG----YL---AESInkdiEECNAIIEQFIDYLRTGQEMPM---EMADLNALLGEVI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 574 Q---GYQLTypkqlFTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEkpISVSLKQNDSAAILTVGNYGPLLPVGL 650
Cdd:PRK09467 305 AaesGYERE-----IETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGW--IKVSSGTEGKRAWFQVEDDGPGIPPEQ 377
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499646591 651 TEHIFDSMV---SVRSQQMQqqphlGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPLV 710
Cdd:PRK09467 378 LKHLFQPFTrgdSARGSSGT-----GLGLAIVKRIVDQHNGKVELGNSEEG-GLSARAWLPLT 434
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
490-708 |
8.49e-06 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 48.85 E-value: 8.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 490 LENMS----SRLSHELRTPVAVVRSSLENLQMQP-QSELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFD 564
Cdd:PRK11006 200 LEGARrnffANVSHELRTPLTVLQGYLEMMQDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 565 LQKVISGCMQGYQ-LTYPKQLFTLDIcQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYG 643
Cdd:PRK11006 280 VPMMLRVLEREAQtLSQGKHTITFEV-DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNG 358
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499646591 644 PLLPvglTEHI------FDSMVSVRSQQMQQQphlGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLP 708
Cdd:PRK11006 359 PGIA---PEHIprlterFYRVDKARSRQTGGS---GLGLAIVKHALSHHDSRLEIE-SEVGKGTRFSFVLP 422
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
464-680 |
1.22e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 48.53 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 464 DANDEIGDLSR--------------SFANIVSRLGGYTNYLENMSSRL----------------SHELRTPVAVVR---S 510
Cdd:COG4192 377 DGNDEIGRIARllrvfrdqaiektqELETEIEERKRIEKNLRQTQDELiqaakmavvgqtmtslAHELNQPLNAMSmylF 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 511 SLENLQMQPQSELSQKYLDRASEGVERLGKIIttmseaTRLEQ-SIQSNEP-EPFDLQKVISGCMQGYQLTYPKQLFTLD 588
Cdd:COG4192 457 SAKKALEQENYAQLPTSLDKIEGLIERMDKII------KSLRQfSRKSDTPlQPVDLRQVIEQAWELVESRAKPQQITLH 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 589 ICQTaLPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQND---SAAILTVGNYGPLLPVGLTEhiFDSMVSVrsqq 665
Cdd:COG4192 531 IPDD-LMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAenlRVAISDNGNGWPLVDKLFTP--FTTTKEV---- 603
|
250
....*....|....*
gi 499646591 666 mqqqpHLGLGLYIVR 680
Cdd:COG4192 604 -----GLGLGLSICR 613
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
600-708 |
3.11e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 43.61 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 600 PEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIV 679
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*....
gi 499646591 680 RLVCDYHNASVTAKNNQQGdGVVFTVSLP 708
Cdd:cd16946 82 HNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
493-711 |
3.69e-05 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 46.89 E-value: 3.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 493 MSSRLSHELRTPVAVVRSSLENLQMQPQSElSQKYLDrasegverlgkIIttMSEATRLEQSI---------QSNEPEPF 563
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDEE-QKTYLD-----------IM--LSELDRIESIIseflvlakpQAIKYEPK 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 564 DLQKVISGCMQgyqLTYPKQL-----FTLDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLK-QNDSAAIL 637
Cdd:COG5809 339 DLNTLIEEVIP---LLQPQALlknvqIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVI 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499646591 638 TVGNYGPLLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAKnNQQGDGVVFTVSLPLVK 711
Cdd:COG5809 416 SVTDEGCGIPEERLKKLGEPFYTTKEKGT------GLGLMVSYKIIEEHGGKITVE-SEVGKGTTFSITLPIKL 482
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
601-702 |
7.64e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 42.45 E-value: 7.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 601 EFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYG-PLLPVGL---TEHIFDSMVSVRSQQmqqqpHLGLGL 676
Cdd:cd16975 3 LLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGhGFSEQDLkkaLELFYRDDTSRRSGG-----HYGMGL 77
|
90 100
....*....|....*....|....*.
gi 499646591 677 YIVRLVCDYHNASVTAKNNQQGDGVV 702
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEV 103
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
607-708 |
1.13e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 41.89 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 607 LDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPhLGLGLYIVRLVCD-- 684
Cdd:cd16948 10 IGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQES-TGMGLYLVKKLCDkl 88
|
90 100
....*....|....*....|....
gi 499646591 685 YHNASVTAKNNQqgdGVVFTVSLP 708
Cdd:cd16948 89 GHKIDVESEVGE---GTTFTITFP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
497-709 |
1.15e-04 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 45.67 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTPVAVVRSSLENLQMQPQSELSQKYLDRASEGVERLGKIITTMSEATRLE---QSIQSNEpEPFDLQKVISGC- 572
Cdd:PRK11466 451 MSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEaggKNVSVSD-EPFEPRPLLESTl 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 573 --MQGYQLTYPKQLFTlDICQtALP--MQGAPEFIAQLLDKLINNAIEFSHaEKPISVSLKQNDSAAILTVGNYGPLLPV 648
Cdd:PRK11466 530 qlMSGRVKGRPIRLAT-DIAD-DLPtaLMGDPRRIRQVITNLLSNALRFTD-EGSIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499646591 649 GLTEHIFDSMVSVRSQQMQQqphlGLGLYIVRLVCDYHNASVTAkNNQQGDGVVFTVSLPL 709
Cdd:PRK11466 607 AKLAEIFQPFVQVSGKRGGT----GLGLTISSRLAQAMGGELSA-TSTPEVGSCFCLRLPL 662
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
414-711 |
3.99e-04 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 43.38 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 414 FNVILAVMLIGTVTLFFFASRISSRIRRLRDTAEQAidAQGRVTGSINYSDANDEIGDLSRSFANIVSRLGGYTNYLENM 493
Cdd:PRK09470 169 LLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEV--AQGNLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQRL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 494 SSRLSHELRTPvavvrssLENLQMqpQSELSQKyldRASEGVErLGKIITtmsEATRLEQSI---------QSN---EPE 561
Cdd:PRK09470 247 LSDISHELRTP-------LTRLQL--ATALLRR---RQGESKE-LERIET---EAQRLDSMIndllvlsrnQQKnhlERE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 562 PFDLQKVISGCMQGYQLTYPKQLFTLDIcqTALP----MQGAPEFIAQLLDKLINNAIEFSHAEkpISVSLKQNDSAAIL 637
Cdd:PRK09470 311 TFKANSLWSEVLEDAKFEAEQMGKSLTV--SAPPgpwpINGNPNALASALENIVRNALRYSHTK--IEVAFSVDKDGLTI 386
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499646591 638 TVGNYGPLLPVGLTEHIFDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNQQGdGVVFTVSLPLVK 711
Cdd:PRK09470 387 TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLG-GLRLTIWLPLYK 459
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
493-710 |
4.69e-04 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 43.18 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 493 MSSRLSHELRTPVAVVRSSLEnlQMQPQSELSQKYLDRASEGVERLGKIIttmSEATRLEQSiQSNEPEPFDLQKVIS-- 570
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQ--LLQPGIEDKEEYFDIMLSELDRIESII---SEFLALAKP-QAVNKEKENINELIQdv 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 571 -------GCMQGYQLtypkQLFTLDICQTalpMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYG 643
Cdd:COG5805 364 vtlleteAILHNIQI----RLELLDEDPF---IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEG 436
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499646591 644 PLLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAKNNqQGDGVVFTVSLPLV 710
Cdd:COG5805 437 IGIPEERLKKLGEPFFTTKEKGT------GLGLMVSYKIIENHNGTIDIDSK-VGKGTTFTITLPLS 496
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
610-708 |
6.00e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 39.88 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 610 LINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPvglTEHI---FDSMVSVRSQQMQQQPHLGLGLYIVRLVCDYH 686
Cdd:cd16952 8 LVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIP---PEHIprlTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|..
gi 499646591 687 NASVTAKnNQQGDGVVFTVSLP 708
Cdd:cd16952 85 DARLLIA-SELGKGSRFTCLFP 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
497-709 |
7.52e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 43.18 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 497 LSHELRTPVAVVRSSLENLQMQPQS-ELSQKYLDRASEGVERLGKIITTMSEATRLEQSIQSNEPEPFDLQKVISGCMQG 575
Cdd:PRK09959 719 MSHEIRTPISSIMGFLELLSGSGLSkEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHS 798
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 576 YQLTYPKQLFTLDiCQTALP----MQGAPEFIAQLLDKLINNAIEF-SHAEKPISVSLKQ-NDSAAI--LTVGNYGPLLP 647
Cdd:PRK09959 799 FGAIAASKSIALS-CSSTFPdhylVKIDPQAFKQVLSNLLSNALKFtTEGAVKITTSLGHiDDNHAVikMTIMDSGSGLS 877
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499646591 648 VGLTEHIFDSMvsVRSQQMQQQPHLGLGLYIVRLVCDYHNASVTAKNNqQGDGVVFTVSLPL 709
Cdd:PRK09959 878 QEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESH-PGIGTTFTITIPV 936
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
604-708 |
7.59e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 39.29 E-value: 7.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 604 AQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVsvRSQQMQQQPHLGLGLYIVRLVC 683
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFY--RGDNSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....*
gi 499646591 684 DYHNASVTAKnnQQGDGVVFTVSLP 708
Cdd:cd16923 80 ELHGGSASAE--YDDNHDLFKVRLP 102
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
498-619 |
1.52e-03 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 41.88 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 498 SHELRTPVAVVRSSLENLQMQpqsELSQkyldraseGVERLgkiITTMSEATRLEQSIQSN--------------EPEPF 563
Cdd:PRK10841 455 SHELRTPLYGIIGNLDLLQTK---ELPK--------GVDRL---VTAMNNSSSLLLKIISDildfskieseqlkiEPREF 520
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499646591 564 DLQKVISGCMQGYQ-LTYPKQLfTL------DICQTalpMQGAPEFIAQLLDKLINNAIEFSH 619
Cdd:PRK10841 521 SPREVINHITANYLpLVVKKRL-GLycfiepDVPVA---LNGDPMRLQQVISNLLSNAIKFTD 579
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
482-680 |
1.62e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 41.82 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 482 RLGGYTNYLENMSSRlSHELRTPVAVVrssLENLQMQPQSELSQKYLDRASEGVERLGKIIttmseatrleQSIQSnepe 561
Cdd:PRK11086 332 RLDGMVNYADALRAQ-SHEFMNKLHVI---LGLLHLKSYDQLEDYILKTANNYQEEIGSLL----------GKIKS---- 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 562 pfdlqKVISGCMQGyQLTYPKQL-FTLDI-CQTALPMQGAPEFIAQL---LDKLINNAIEF--SHAEKPISVSLKQNDSA 634
Cdd:PRK11086 394 -----PVIAGFLLG-KISRARELgITLIIsEDSQLPDSGDEDQVHELitiLGNLIENALEAvgGEEGGEISVSLHYRNGW 467
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 499646591 635 AILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVR 680
Cdd:PRK11086 468 LHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNR------GVGLYLVK 507
|
|
| CBM9_1 |
pfam06452 |
Carbohydrate family 9 binding domain-like; CBM9_1 is a C-terminal domain on bacterial xylanase ... |
88-259 |
2.04e-03 |
|
Carbohydrate family 9 binding domain-like; CBM9_1 is a C-terminal domain on bacterial xylanase proteins, and it is tandemly repeated in a number of family-members. The CBM9 module binds to amorphous and crystalline cellulose and a range of soluble di- and monosaccharides as well as to cello- and xylo- oligomers of different degrees of polymerization. Comparison of the glucose and cellobiose complexes during crystallization reveals surprising differences in binding of these two substrates by CBM9-2. Cellobiose was found to bind in a distinct orientation from glucose, while still maintaining optimal stacking and electrostatic interactions with the reducing end sugar.
Pssm-ID: 428950 Cd Length: 180 Bit Score: 39.64 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 88 LDGKL-TDWESYQALfwqydkrylqkTDNKHQ----ASDLSfehmvGKF-----DNYLYALFKVTDNQL------VYR-- 149
Cdd:pfam06452 1 IDGTVdAVWSNAQSL-----------TIFKLWtgtvSSDAS-----GTFkalwdDDNLYVLAEVTDDVLndgstnPWEdd 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 150 -------PKNSLSITNNDHlkiglktpDGQFNRyiiaprqdGWVNA--FNADSKVPFTKIQGYFSSTAAGYNIELRFPIS 220
Cdd:pfam06452 65 sveifidENNGKTTEYGAN--------DFQYRV--------NYNNEtsFDPGNGLIAAGFTSASKVSDGGYIVEAKIPLK 128
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 499646591 221 ML-----GNKLGFAI-IDVDNKEPLLEPKIMST----SNLNNPSDLGSV 259
Cdd:pfam06452 129 TIttpanNKVIGFDVqINDDDDGGTRQGKITWNdptgNAWQDPSVFGTV 177
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
587-707 |
3.18e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 38.26 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 587 LDICQTALPMQGAPEFIAQLLDKLINNAIEFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQM 666
Cdd:cd16947 5 INIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRN 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 499646591 667 QQQPHLGLGLYIVRLVCDYHNASVTAkNNQQGDGVVFTVSL 707
Cdd:cd16947 85 SAKQGNGLGLTITKRLAESMGGSIYV-NSKPYEKTVFTVTL 124
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
634-708 |
3.39e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 37.77 E-value: 3.39e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499646591 634 AAILTVGNYGPLLPVGLTEHIFDSMVSVRSQQMqqqphlGLGLYIVRLVCDYHNASVTAkNNQQGDgVVFTVSLP 708
Cdd:cd16918 43 ALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGT------GLGLAIAQNIVSQHGGVIEC-DSQPGH-TVFSVSLP 109
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| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
603-708 |
3.58e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 37.43 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 603 IAQLLDKLINNAieFSHAEKPISVSLKQNDSAAILTVGNYGPLLPVGLTEHIFDSMVsvRSQQMQQQPHLGLGLYIVRLV 682
Cdd:cd16950 1 LKRVLSNLVDNA--LRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFY--RGDNARGTSGTGLGLAIVQRI 76
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90 100
....*....|....*....|....*.
gi 499646591 683 CDYHNASVTAKNNQQGdGVVFTVSLP 708
Cdd:cd16950 77 SDAHGGSLTLANRAGG-GLCARIELP 101
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| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
556-709 |
4.63e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.27 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 556 QSNEPEPFDLQKVISGCMQGYQLTYPKQL--FTLDICQTALPMQGA-PefIAQLLDKLINNAIE--FSHAEKP-ISVSLK 629
Cdd:COG3920 352 QSEDWEGVDLRDYLRELLEPLRDSYGGRGirIELDGPDVELPADAAvP--LGLILNELVTNALKhaFLSGEGGrIRVSWR 429
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499646591 630 QNDSAAILTVGNYGPLLPVGltehifdsmVSVRSQQmqqqphlGLGLYIVRLVCDYHNASVTAKNnqqGDGVVFTVSLPL 709
Cdd:COG3920 430 REDGRLRLTVSDNGVGLPED---------VDPPARK-------GLGLRLIRALVRQLGGTLELDR---PEGTRVRITFPL 490
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