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Conserved domains on  [gi|500777000|ref|WP_011994808|]
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MULTISPECIES: PhoPQ-activated pathogenicity-related family protein [Fervidobacterium]

Protein Classification

PhoPQ-activated pathogenicity-related family protein( domain architecture ID 10562496)

PhoPQ-activated pathogenicity-related family protein similar to Dictyostelium discoideum autocrine proliferation repressor protein A (AprA) that slows proliferation of secreting cells and may function by binding to cell surface receptors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhoPQ_related pfam10142
PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins ...
 22-363 1.49e-153

PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.


:

Pssm-ID: 401951  Cd Length: 366  Bit Score: 439.07  E-value: 1.49e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   22 LSEYILSSGQP-SYELTTSTNSIvGGKLFILDMKSQIWRGIE------WNHKVVIYVPKKLLYKSEAILFVSGS-----A 89
Cdd:pfam10142   1 LADYVEKPDPPyKYTLTATYETA-GVTIYILELTSQTWSPDQlvdpslWKHWVTIYVPDDLALPETALLIISGGsngnwK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   90 PKNIIGEANKYLGIAELVGAPLIILFDIPNQPL-FG-----LREDALIAYTFAKYFE-TQEEDWPLLLPMVKSVISTMDC 162
Cdd:pfam10142  80 TPPPDSEPETLAEIARQTGTVVAELSDVPNQPLtFDgdgrpRREDALVAYTWRKFLEpTQDPTWPLLLPMTKAAVRAMDL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  163 TQDFLKSQGIKIEKFLVTGASKRGWTTYLTGAVDNRVLGIVPIVYDNLNMREQMKKQLEYYGTFSEQIRDYTKYGFTEMV 242
Cdd:pfam10142 160 AQEFLKTLGYKIEKFVVTGASKRGWTTWLTAAVDKRVKAIAPMVIDILNMRKQLKHQYKSYGNWSEALNDYVAEGIDDML 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  243 aKSEEVPELVKLVDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSEPKYVRFIPNDVHNLKNtMEVFSAIRTFFI 320
Cdd:pfam10142 240 -GTPAFDELLKIVDPYSYlqRLTMPKYIINASGDDFFVPDSTQFYFDDLPGEKYLRYVPNTSHGLIN-QQVVESLVPFFK 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 500777000  321 L-CVERKLPDFSWEMLDDG----VKIVTHDEVEYVKGWYATSES-LDFR 363
Cdd:pfam10142 318 RvQAGRPLPELSWSIEGSAgtisVKVRSSEAPVKVKLWTATNPSaRDFR 366
 
Name Accession Description Interval E-value
PhoPQ_related pfam10142
PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins ...
 22-363 1.49e-153

PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.


Pssm-ID: 401951  Cd Length: 366  Bit Score: 439.07  E-value: 1.49e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   22 LSEYILSSGQP-SYELTTSTNSIvGGKLFILDMKSQIWRGIE------WNHKVVIYVPKKLLYKSEAILFVSGS-----A 89
Cdd:pfam10142   1 LADYVEKPDPPyKYTLTATYETA-GVTIYILELTSQTWSPDQlvdpslWKHWVTIYVPDDLALPETALLIISGGsngnwK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   90 PKNIIGEANKYLGIAELVGAPLIILFDIPNQPL-FG-----LREDALIAYTFAKYFE-TQEEDWPLLLPMVKSVISTMDC 162
Cdd:pfam10142  80 TPPPDSEPETLAEIARQTGTVVAELSDVPNQPLtFDgdgrpRREDALVAYTWRKFLEpTQDPTWPLLLPMTKAAVRAMDL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  163 TQDFLKSQGIKIEKFLVTGASKRGWTTYLTGAVDNRVLGIVPIVYDNLNMREQMKKQLEYYGTFSEQIRDYTKYGFTEMV 242
Cdd:pfam10142 160 AQEFLKTLGYKIEKFVVTGASKRGWTTWLTAAVDKRVKAIAPMVIDILNMRKQLKHQYKSYGNWSEALNDYVAEGIDDML 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  243 aKSEEVPELVKLVDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSEPKYVRFIPNDVHNLKNtMEVFSAIRTFFI 320
Cdd:pfam10142 240 -GTPAFDELLKIVDPYSYlqRLTMPKYIINASGDDFFVPDSTQFYFDDLPGEKYLRYVPNTSHGLIN-QQVVESLVPFFK 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 500777000  321 L-CVERKLPDFSWEMLDDG----VKIVTHDEVEYVKGWYATSES-LDFR 363
Cdd:pfam10142 318 RvQAGRPLPELSWSIEGSAgtisVKVRSSEAPVKVKLWTATNPSaRDFR 366
PqaA COG4287
PhoPQ-activated pathogenicity-related protein [General function prediction only];
4-369 4.25e-127

PhoPQ-activated pathogenicity-related protein [General function prediction only];


Pssm-ID: 443428  Cd Length: 440  Bit Score: 374.27  E-value: 4.25e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   4 LIVILISASVFSVIFGIT----LSEYILSSGQP-SYELTTSTNsIVGGKLFILDMKSQIWRGIEWNHKVVIYVPKKLLYk 78
Cdd:COG4287    2 ALALLLLAAGAAAAAAVTpetaLKDYVNNRDPPlKWELKDTTT-LGGVTVYELLLTSQKWRPITWKHQLTIFVPKEVLP- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  79 SEAILFVSGSAPKNIIGEANK--------YLGIAELVGAPLIILFDIPNQPLF-GLREDALIAYTFAKYFETQEEDWPLL 149
Cdd:COG4287   80 DGALLFITGGSNKPEQPNWPPpgdfdpelLAAIARKTKAIVALLSQVPNQPLFgGLREDALIAYTWHQFLKDPDYTWPLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 150 LPMVKSVISTMDCTQDFLKSQ-GIKIEKFLVTGASKRGWTTYLTGAVDNRVLGIVPIVYDNLNMREQMKKQLEYYGTFSE 228
Cdd:COG4287  160 FPMVKSAVRAMDAVQEFLKQElGKEIKRFVVTGASKRGWTTWLTAAADPRVKAIAPMVIDVLNMPASLEHQYKVYGGYSI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 229 QIRDYTKYGFTEMVaKSEEVPELVKLVDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSEPKYVRFIPNDVHNLK 306
Cdd:COG4287  240 AIEDYVKLGIPQQL-GTPAGKALMQMVDPYSYraRLTMPKYIVNGSNDDYWVPDAIKHYYDDLPGEKALRYVPNAGHGLG 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500777000 307 NTMEVFSAIRTFF-ILCVERKLPDFSW--EMLDDGVKIVTH--DEVEYVKGWYATSESLDFRKSKWES 369
Cdd:COG4287  319 DGKQAVEALSAFFgRTLQGRPLPQVSWklDETGKGARLTVAssEAPVKAKLWTATSEDRDFRGVRWTS 386
 
Name Accession Description Interval E-value
PhoPQ_related pfam10142
PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins ...
 22-363 1.49e-153

PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.


Pssm-ID: 401951  Cd Length: 366  Bit Score: 439.07  E-value: 1.49e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   22 LSEYILSSGQP-SYELTTSTNSIvGGKLFILDMKSQIWRGIE------WNHKVVIYVPKKLLYKSEAILFVSGS-----A 89
Cdd:pfam10142   1 LADYVEKPDPPyKYTLTATYETA-GVTIYILELTSQTWSPDQlvdpslWKHWVTIYVPDDLALPETALLIISGGsngnwK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   90 PKNIIGEANKYLGIAELVGAPLIILFDIPNQPL-FG-----LREDALIAYTFAKYFE-TQEEDWPLLLPMVKSVISTMDC 162
Cdd:pfam10142  80 TPPPDSEPETLAEIARQTGTVVAELSDVPNQPLtFDgdgrpRREDALVAYTWRKFLEpTQDPTWPLLLPMTKAAVRAMDL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  163 TQDFLKSQGIKIEKFLVTGASKRGWTTYLTGAVDNRVLGIVPIVYDNLNMREQMKKQLEYYGTFSEQIRDYTKYGFTEMV 242
Cdd:pfam10142 160 AQEFLKTLGYKIEKFVVTGASKRGWTTWLTAAVDKRVKAIAPMVIDILNMRKQLKHQYKSYGNWSEALNDYVAEGIDDML 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  243 aKSEEVPELVKLVDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSEPKYVRFIPNDVHNLKNtMEVFSAIRTFFI 320
Cdd:pfam10142 240 -GTPAFDELLKIVDPYSYlqRLTMPKYIINASGDDFFVPDSTQFYFDDLPGEKYLRYVPNTSHGLIN-QQVVESLVPFFK 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 500777000  321 L-CVERKLPDFSWEMLDDG----VKIVTHDEVEYVKGWYATSES-LDFR 363
Cdd:pfam10142 318 RvQAGRPLPELSWSIEGSAgtisVKVRSSEAPVKVKLWTATNPSaRDFR 366
PqaA COG4287
PhoPQ-activated pathogenicity-related protein [General function prediction only];
4-369 4.25e-127

PhoPQ-activated pathogenicity-related protein [General function prediction only];


Pssm-ID: 443428  Cd Length: 440  Bit Score: 374.27  E-value: 4.25e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000   4 LIVILISASVFSVIFGIT----LSEYILSSGQP-SYELTTSTNsIVGGKLFILDMKSQIWRGIEWNHKVVIYVPKKLLYk 78
Cdd:COG4287    2 ALALLLLAAGAAAAAAVTpetaLKDYVNNRDPPlKWELKDTTT-LGGVTVYELLLTSQKWRPITWKHQLTIFVPKEVLP- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000  79 SEAILFVSGSAPKNIIGEANK--------YLGIAELVGAPLIILFDIPNQPLF-GLREDALIAYTFAKYFETQEEDWPLL 149
Cdd:COG4287   80 DGALLFITGGSNKPEQPNWPPpgdfdpelLAAIARKTKAIVALLSQVPNQPLFgGLREDALIAYTWHQFLKDPDYTWPLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 150 LPMVKSVISTMDCTQDFLKSQ-GIKIEKFLVTGASKRGWTTYLTGAVDNRVLGIVPIVYDNLNMREQMKKQLEYYGTFSE 228
Cdd:COG4287  160 FPMVKSAVRAMDAVQEFLKQElGKEIKRFVVTGASKRGWTTWLTAAADPRVKAIAPMVIDVLNMPASLEHQYKVYGGYSI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 229 QIRDYTKYGFTEMVaKSEEVPELVKLVDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSEPKYVRFIPNDVHNLK 306
Cdd:COG4287  240 AIEDYVKLGIPQQL-GTPAGKALMQMVDPYSYraRLTMPKYIVNGSNDDYWVPDAIKHYYDDLPGEKALRYVPNAGHGLG 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500777000 307 NTMEVFSAIRTFF-ILCVERKLPDFSW--EMLDDGVKIVTH--DEVEYVKGWYATSESLDFRKSKWES 369
Cdd:COG4287  319 DGKQAVEALSAFFgRTLQGRPLPQVSWklDETGKGARLTVAssEAPVKAKLWTATSEDRDFRGVRWTS 386
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
165-319 6.72e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 41.16  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 165 DFLKSQG-IKIEKFLVTGASKRGWTTYLTGAVDNRVL-GIVPI--VYDNLNMREQMKKQLE-YYGTFSEQIRDYTKYgft 239
Cdd:COG1506   82 DYLAARPyVDPDRIGIYGHSYGGYMALLAAARHPDRFkAAVALagVSDLRSYYGTTREYTErLMGGPWEDPEAYAAR--- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500777000 240 emvakseevpelvklvDPYYY--EINVPKLIIAGTNDPYWVIDSSELYFYDLSE---PKYVRFIPNDVHNL--KNTMEVF 312
Cdd:COG1506  159 ----------------SPLAYadKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFsgAGAPDYL 222


                 ....*..
gi 500777000 313 SAIRTFF 319
Cdd:COG1506  223 ERILDFL 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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