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Conserved domains on  [gi|50403735|sp|P33005|]
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RecName: Full=Anosmin-1; AltName: Full=Kallmann syndrome protein homolog; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 39-119 4.85e-43

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


:

Pssm-ID: 465542  Cd Length: 82  Bit Score: 149.66  E-value: 4.85e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    39 STARCTSRCLSLQITRISAFFKHFQNNGSLAWCQNHKQCSKCLEPCKESWDLKKNHCQSFCEPLFPKKNYECLTSCEFLK 118
Cdd:pfam17869   2 NRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFLK 81


                  .
gi 50403735   119 Y 119
Cdd:pfam17869  82 S 82
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 105-170 1.77e-17

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


:

Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 76.72  E-value: 1.77e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50403735 105 KKNYECLTSCEflkyILSVKQGDCPAPEKASgfAAACVESCEADSECSGVKKCCSNGCGHTCQVPK 170
Cdd:cd00199   1 GNNMTKPGSCP----RPVEKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 284-374 2.48e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 284 PPAPSNIRIANISANNdgtvnVMITWDLPEEPDIPVHHYKVFWSWTYSKYVIPAKKkrrkiTDGPQNYVVLEGLQPNSNY 363
Cdd:cd00063   1 PSPPTNLRVTDVTSTS-----VTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV-----TPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|.
gi 50403735 364 NVELQAVTRWG 374
Cdd:cd00063  71 EFRVRAVNGGG 81
fn3 pfam00041
Fibronectin type III domain;
545-641 1.74e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   545 KPENLSASFIvqeGNITGHFSWKISKaVLHQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPADHYVLTVPNLRPSML 624
Cdd:pfam00041   2 APSNLTVTDV---TSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 50403735   625 YRLEVQVLTTGGEGPAT 641
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
180-269 4.31e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   180 PRKELKFIELQSGDLEVKWSSKFNISIEPVIYVVQRRwnqgiHPSEDDATNWQTVAQTTDeRVQLSDIRASRWYQFRVAA 259
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 50403735   260 VNVHGTRGFT 269
Cdd:pfam00041  76 VNGGGEGPPS 85
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 39-119 4.85e-43

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 149.66  E-value: 4.85e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    39 STARCTSRCLSLQITRISAFFKHFQNNGSLAWCQNHKQCSKCLEPCKESWDLKKNHCQSFCEPLFPKKNYECLTSCEFLK 118
Cdd:pfam17869   2 NRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFLK 81


                  .
gi 50403735   119 Y 119
Cdd:pfam17869  82 S 82
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 105-170 1.77e-17

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 76.72  E-value: 1.77e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50403735 105 KKNYECLTSCEflkyILSVKQGDCPAPEKASgfAAACVESCEADSECSGVKKCCSNGCGHTCQVPK 170
Cdd:cd00199   1 GNNMTKPGSCP----RPVEKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
124-170 2.71e-16

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 72.79  E-value: 2.71e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 50403735    124 KQGDCPAPEKASGFAAACVESCEADSECSGVKKCCSNGCGHTCQVPK 170
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 124-169 1.80e-12

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 62.06  E-value: 1.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 50403735   124 KQGDCPAPekasGFAAACVESCEADSECSGVKKCCSNGCGHTCQVP 169
Cdd:pfam00095   1 KPGCCPRL----GARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 284-374 2.48e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 284 PPAPSNIRIANISANNdgtvnVMITWDLPEEPDIPVHHYKVFWSWTYSKYVIPAKKkrrkiTDGPQNYVVLEGLQPNSNY 363
Cdd:cd00063   1 PSPPTNLRVTDVTSTS-----VTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV-----TPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|.
gi 50403735 364 NVELQAVTRWG 374
Cdd:cd00063  71 EFRVRAVNGGG 81
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
226-376 3.66e-11

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 66.51  E-value: 3.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 226 DDATNWQTVAQTTDERVQLSDIRASRwYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPSNIRianISANNDGtvnV 305
Cdd:COG4733 573 RDDGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT---ATGGLGG---I 645

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50403735 306 MITWDLPEEPDIPvhHYKVFWS----WTYSKYVipakkkrrkITDGPQNYVVLEGLQPNSNYNVELQAVTRWGQI 376
Cdd:COG4733 646 TLSWSFPVDADTL--RTEIRYSttgdWASATVA---------QALYPGNTYTLAGLKAGQTYYYRARAVDRSGNV 709
fn3 pfam00041
Fibronectin type III domain;
285-372 2.94e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   285 PAPSNIRIANISANNdgtvnVMITWDLPEEPDIPVHHYKVFWSWTYSKyvipaKKKRRKITDGPQNYVVLEGLQPNSNYN 364
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-----LTVSWTPPPDGNGPITGYEVEYRPKNSG-----EPWNEITVPGTTTSVTLTGLKPGTEYE 70


                  ....*...
gi 50403735   365 VELQAVTR 372
Cdd:pfam00041  71 VRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 284-375 4.77e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 4.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    284 PPAPSNIRIANISANNdgtvnVMITWDLPEEPdiPVHHYKVFWSWTYSKyviPAKKKRRKITDGPQNYVVLEGLQPNSNY 363
Cdd:smart00060   1 PSPPSNLRVTDVTSTS-----VTLSWEPPPDD--GITGYIVGYRVEYRE---EGSEWKEVNVTPSSTSYTLTGLKPGTEY 70

                           90
                   ....*....|..
gi 50403735    364 NVELQAVTRWGQ 375
Cdd:smart00060  71 EFRVRAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
545-641 1.74e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   545 KPENLSASFIvqeGNITGHFSWKISKaVLHQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPADHYVLTVPNLRPSML 624
Cdd:pfam00041   2 APSNLTVTDV---TSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 50403735   625 YRLEVQVLTTGGEGPAT 641
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
180-269 4.31e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   180 PRKELKFIELQSGDLEVKWSSKFNISIEPVIYVVQRRwnqgiHPSEDDATNWQTVAQTTDeRVQLSDIRASRWYQFRVAA 259
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 50403735   260 VNVHGTRGFT 269
Cdd:pfam00041  76 VNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
176-447 2.28e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 2.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 176 VPLKPrKELKFIELQSGDLEVKWSSKFNISIEPviYVVQRrwnqgihpSEDDATNWQTVAQTTDERVQLSDIRASRWYQF 255
Cdd:COG3401 232 PPSAP-TGLTATADTPGSVTLSWDPVTESDATG--YRVYR--------SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYY 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 256 RVAAVNVHGTRGftAPSKHFRSSKDPSAPPAPSniriaNISANNDGTVNVMITWDLPEEPDipVHHYKVFWS----WTYS 331
Cdd:COG3401 301 RVTAVDAAGNES--APSNVVSVTTDLTPPAAPS-----GLTATAVGSSSITLSWTASSDAD--VTGYNVYRStsggGTYT 371

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 332 KYVIPAKKkrrkitdgpqNYVVLEGLQPNSNYNVELQAVTRWG---------QIRLKSAKVSLHFSTAQDNRNNNEQTSA 402
Cdd:COG3401 372 KIAETVTT----------TSYTDTGLTPGTTYYYKVTAVDAAGnesapseevSATTASAASGESLTASVDAVPLTDVAGA 441

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 50403735 403 GKPPKGLVDPYPTFQRRKPTRFLKIGTPFYQDNQLQVKVYWKKTD 447
Cdd:COG3401 442 TAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 177-276 5.02e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 177 PLKPRKeLKFIELQSGDLEVKWSSKFNISIEPVIYVVQRRwnqgihpsEDDATNWQTV--AQTTDERVQLSDIRASRWYQ 254
Cdd:cd00063   1 PSPPTN-LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVevTPGSETSYTLTGLKPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 50403735 255 FRVAAVNVHGtRGFTAPSKHFR 276
Cdd:cd00063  72 FRVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 177-264 1.85e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    177 PLKPRKeLKFIELQSGDLEVKWS-SKFNISIEPVI-YVVQRRwnqgihpseDDATNWQTVAQTTDE-RVQLSDIRASRWY 253
Cdd:smart00060   1 PSPPSN-LRVTDVTSTSVTLSWEpPPDDGITGYIVgYRVEYR---------EEGSEWKEVNVTPSStSYTLTGLKPGTEY 70

                           90
                   ....*....|.
gi 50403735    254 QFRVAAVNVHG 264
Cdd:smart00060  71 EFRVRAVNGAG 81
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 39-119 4.85e-43

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 149.66  E-value: 4.85e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    39 STARCTSRCLSLQITRISAFFKHFQNNGSLAWCQNHKQCSKCLEPCKESWDLKKNHCQSFCEPLFPKKNYECLTSCEFLK 118
Cdd:pfam17869   2 NRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFLK 81


                  .
gi 50403735   119 Y 119
Cdd:pfam17869  82 S 82
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 105-170 1.77e-17

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 76.72  E-value: 1.77e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50403735 105 KKNYECLTSCEflkyILSVKQGDCPAPEKASgfAAACVESCEADSECSGVKKCCSNGCGHTCQVPK 170
Cdd:cd00199   1 GNNMTKPGSCP----RPVEKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
124-170 2.71e-16

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 72.79  E-value: 2.71e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 50403735    124 KQGDCPAPEKASGFAAACVESCEADSECSGVKKCCSNGCGHTCQVPK 170
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 124-169 1.80e-12

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 62.06  E-value: 1.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 50403735   124 KQGDCPAPekasGFAAACVESCEADSECSGVKKCCSNGCGHTCQVP 169
Cdd:pfam00095   1 KPGCCPRL----GARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 284-374 2.48e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 284 PPAPSNIRIANISANNdgtvnVMITWDLPEEPDIPVHHYKVFWSWTYSKYVIPAKKkrrkiTDGPQNYVVLEGLQPNSNY 363
Cdd:cd00063   1 PSPPTNLRVTDVTSTS-----VTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV-----TPGSETSYTLTGLKPGTEY 70

                        90
                ....*....|.
gi 50403735 364 NVELQAVTRWG 374
Cdd:cd00063  71 EFRVRAVNGGG 81
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
226-376 3.66e-11

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 66.51  E-value: 3.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 226 DDATNWQTVAQTTDERVQLSDIRASRwYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPSNIRianISANNDGtvnV 305
Cdd:COG4733 573 RDDGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT---ATGGLGG---I 645

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50403735 306 MITWDLPEEPDIPvhHYKVFWS----WTYSKYVipakkkrrkITDGPQNYVVLEGLQPNSNYNVELQAVTRWGQI 376
Cdd:COG4733 646 TLSWSFPVDADTL--RTEIRYSttgdWASATVA---------QALYPGNTYTLAGLKAGQTYYYRARAVDRSGNV 709
fn3 pfam00041
Fibronectin type III domain;
285-372 2.94e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   285 PAPSNIRIANISANNdgtvnVMITWDLPEEPDIPVHHYKVFWSWTYSKyvipaKKKRRKITDGPQNYVVLEGLQPNSNYN 364
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-----LTVSWTPPPDGNGPITGYEVEYRPKNSG-----EPWNEITVPGTTTSVTLTGLKPGTEYE 70


                  ....*...
gi 50403735   365 VELQAVTR 372
Cdd:pfam00041  71 VRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 284-375 4.77e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 4.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    284 PPAPSNIRIANISANNdgtvnVMITWDLPEEPdiPVHHYKVFWSWTYSKyviPAKKKRRKITDGPQNYVVLEGLQPNSNY 363
Cdd:smart00060   1 PSPPSNLRVTDVTSTS-----VTLSWEPPPDD--GITGYIVGYRVEYRE---EGSEWKEVNVTPSSTSYTLTGLKPGTEY 70

                           90
                   ....*....|..
gi 50403735    364 NVELQAVTRWGQ 375
Cdd:smart00060  71 EFRVRAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
545-641 1.74e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   545 KPENLSASFIvqeGNITGHFSWKISKaVLHQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPADHYVLTVPNLRPSML 624
Cdd:pfam00041   2 APSNLTVTDV---TSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 50403735   625 YRLEVQVLTTGGEGPAT 641
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
180-269 4.31e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735   180 PRKELKFIELQSGDLEVKWSSKFNISIEPVIYVVQRRwnqgiHPSEDDATNWQTVAQTTDeRVQLSDIRASRWYQFRVAA 259
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 50403735   260 VNVHGTRGFT 269
Cdd:pfam00041  76 VNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
176-447 2.28e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 2.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 176 VPLKPrKELKFIELQSGDLEVKWSSKFNISIEPviYVVQRrwnqgihpSEDDATNWQTVAQTTDERVQLSDIRASRWYQF 255
Cdd:COG3401 232 PPSAP-TGLTATADTPGSVTLSWDPVTESDATG--YRVYR--------SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYY 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 256 RVAAVNVHGTRGftAPSKHFRSSKDPSAPPAPSniriaNISANNDGTVNVMITWDLPEEPDipVHHYKVFWS----WTYS 331
Cdd:COG3401 301 RVTAVDAAGNES--APSNVVSVTTDLTPPAAPS-----GLTATAVGSSSITLSWTASSDAD--VTGYNVYRStsggGTYT 371

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 332 KYVIPAKKkrrkitdgpqNYVVLEGLQPNSNYNVELQAVTRWG---------QIRLKSAKVSLHFSTAQDNRNNNEQTSA 402
Cdd:COG3401 372 KIAETVTT----------TSYTDTGLTPGTTYYYKVTAVDAAGnesapseevSATTASAASGESLTASVDAVPLTDVAGA 441

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 50403735 403 GKPPKGLVDPYPTFQRRKPTRFLKIGTPFYQDNQLQVKVYWKKTD 447
Cdd:COG3401 442 TAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
226-384 3.93e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 3.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 226 DDATNWQTVAQTTDERVQLSDIRASRWYQFRVAAVNVHGTRgftAPSKHFRSSKDPSAPPAPSniriaNISANNDGTVNV 305
Cdd:COG3401 178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGES---APSNEVSVTTPTTPPSAPT-----GLTATADTPGSV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 306 MITWDLPEEPDipVHHYKVFWSWTYS-KYVipakkkrrKITDGPQNYVVLEGLQPNSNYNVELQAVTRWGQIRLKSAKVS 384
Cdd:COG3401 250 TLSWDPVTESD--ATGYRVYRSNSGDgPFT--------KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVS 319
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 177-276 5.02e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735 177 PLKPRKeLKFIELQSGDLEVKWSSKFNISIEPVIYVVQRRwnqgihpsEDDATNWQTV--AQTTDERVQLSDIRASRWYQ 254
Cdd:cd00063   1 PSPPTN-LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVevTPGSETSYTLTGLKPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 50403735 255 FRVAAVNVHGtRGFTAPSKHFR 276
Cdd:cd00063  72 FRVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 177-264 1.85e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50403735    177 PLKPRKeLKFIELQSGDLEVKWS-SKFNISIEPVI-YVVQRRwnqgihpseDDATNWQTVAQTTDE-RVQLSDIRASRWY 253
Cdd:smart00060   1 PSPPSN-LRVTDVTSTSVTLSWEpPPDDGITGYIVgYRVEYR---------EEGSEWKEVNVTPSStSYTLTGLKPGTEY 70

                           90
                   ....*....|.
gi 50403735    254 QFRVAAVNVHG 264
Cdd:smart00060  71 EFRVRAVNGAG 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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