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Conserved domains on  [gi|50550407|ref|XP_502676|]
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YALI0D10923p [Yarrowia lipolytica CLIB122]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10184738)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may bind DNA and function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 154-201 4.09e-18

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


:

Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 77.22  E-value: 4.09e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 154 RWTQEETADLMEGCKVHGVGNWKKILTDPrFRFNNRTAVDLKDRFRTC 201
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDY-FFVNNRTSVDLKDKWRNL 48
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 240-286 2.02e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


:

Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.18  E-value: 2.02e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 240 RVFTPEEDERLLNGFMKHGP-SWSNIQRDNELGLfERRSTDLRDRFRN 286
Cdd:cd11660   1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFVN-NRTSVDLKDKWRN 47
 
Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 154-201 4.09e-18

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 77.22  E-value: 4.09e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 154 RWTQEETADLMEGCKVHGVGNWKKILTDPrFRFNNRTAVDLKDRFRTC 201
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDY-FFVNNRTSVDLKDKWRNL 48
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
152-200 4.62e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.14  E-value: 4.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 50550407    152 RLRWTQEETADLMEGCKVHGVGNWKKILTdprfRFNNRTAVDLKDRFRT 200
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAK----ELPGRTAEQCRERWRN 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 240-286 2.02e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.18  E-value: 2.02e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 240 RVFTPEEDERLLNGFMKHGP-SWSNIQRDNELGLfERRSTDLRDRFRN 286
Cdd:cd11660   1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFVN-NRTSVDLKDKWRN 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 152-200 1.02e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.19  E-value: 1.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 50550407   152 RLRWTQEETADLMEGCKVHGvGNWKKILTdprfRFNNRTAVDLKDRFRT 200
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAK----LLPGRTDNQCKNRWQN 44
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 239-286 3.31e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 43.65  E-value: 3.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 50550407   239 RRVFTPEEDERLLNGFMKHGPSWSNIQRdnelgLFERRST-DLRDRFRN 286
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAK-----LLPGRTDnQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
239-286 3.91e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.67  E-value: 3.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 50550407    239 RRVFTPEEDERLLNGFMKHGP-SWSNIQRDnelgLFERRSTDLRDRFRN 286
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKE----LPGRTAEQCRERWRN 45
 
Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 154-201 4.09e-18

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 77.22  E-value: 4.09e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 154 RWTQEETADLMEGCKVHGVGNWKKILTDPrFRFNNRTAVDLKDRFRTC 201
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDY-FFVNNRTSVDLKDKWRNL 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 154-200 1.74e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 50.27  E-value: 1.74e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 50550407 154 RWTQEETADLMEGCKVHGVGNWKKILTdprfRFNNRTAVDLKDRFRT 200
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAK----ELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
152-200 4.62e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 49.14  E-value: 4.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 50550407    152 RLRWTQEETADLMEGCKVHGVGNWKKILTdprfRFNNRTAVDLKDRFRT 200
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAK----ELPGRTAEQCRERWRN 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 240-286 2.02e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.18  E-value: 2.02e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 50550407 240 RVFTPEEDERLLNGFMKHGP-SWSNIQRDNELGLfERRSTDLRDRFRN 286
Cdd:cd11660   1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFVN-NRTSVDLKDKWRN 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 152-200 1.02e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.19  E-value: 1.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 50550407   152 RLRWTQEETADLMEGCKVHGvGNWKKILTdprfRFNNRTAVDLKDRFRT 200
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAK----LLPGRTDNQCKNRWQN 44
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 239-286 3.31e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 43.65  E-value: 3.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 50550407   239 RRVFTPEEDERLLNGFMKHGPSWSNIQRdnelgLFERRST-DLRDRFRN 286
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAK-----LLPGRTDnQCKNRWQN 44
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 242-289 1.42e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 42.30  E-value: 1.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 50550407   242 FTPEEDERLLNGFMKHGPSWSNIQRdnELGlfERRSTDLRDRFRNAFP 289
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAK--ELG--RRTPKQCFDRWRRKLN 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 242-286 2.97e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.02  E-value: 2.97e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 50550407 242 FTPEEDERLLNGFMKHGP-SWSNIQRDnelgLFERRSTDLRDRFRN 286
Cdd:cd00167   2 WTEEEDELLLEAVKKYGKnNWEKIAKE----LPGRTPKQCRERWRN 43
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 155-199 3.91e-05

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 40.85  E-value: 3.91e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 50550407 155 WTQEETADLMEGCKVHGVgNWKKILTdpRFRFNN-RTAVDLKDRFR 199
Cdd:cd11658   1 WTKEETDYLFDLVKRFDL-RWNVILD--RYPFQKgRSVEDLKEKYY 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
239-286 3.91e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.67  E-value: 3.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 50550407    239 RRVFTPEEDERLLNGFMKHGP-SWSNIQRDnelgLFERRSTDLRDRFRN 286
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKE----LPGRTAEQCRERWRN 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 155-208 8.74e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 37.29  E-value: 8.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 50550407   155 WTQEETADLMEGCKVHGvGNWKKILTDprfrFNNRTAVDLKDRFRTCFPEDYRR 208
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKE----LGRRTPKQCFDRWRRKLNPKISR 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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