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Conserved domains on  [gi|514829648]
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Chain A, Protein Fam105b

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OTU_OTUL cd22799
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also ...
3-268 0e+00

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


:

Pssm-ID: 438620  Cd Length: 266  Bit Score: 517.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648   3 LSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPE 82
Cdd:cd22799    1 LSVAPEMDILDYCKKEWRGNTQKATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQALSQAVGLPPWLQDPELMLLPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  83 KLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNR 162
Cdd:cd22799   81 KLISKYNWIKQWKLGLKFDGKNEDLVDKLKEYLTLLKKKWAGLAEMRTAEERQIACDELFTNEAEEYSLYEAVKFLMLNR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 163 AIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY 242
Cdd:cd22799  161 AIELYNDKEKGKEVPFFSWLLFARDTSNNPGQLLRNHLNQVGHSGGLEQVEMFLLGYALQHTIQVYRLYKYNTEEFITVY 240
                        250       260
                 ....*....|....*....|....*.
gi 514829648 243 PTDPPKDWPVVTLIAEADRHYNIPVR 268
Cdd:cd22799  241 PTDPPKDWPVVTLITEDDRHYNIPVR 266
 
Name Accession Description Interval E-value
OTU_OTUL cd22799
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also ...
3-268 0e+00

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438620  Cd Length: 266  Bit Score: 517.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648   3 LSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPE 82
Cdd:cd22799    1 LSVAPEMDILDYCKKEWRGNTQKATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQALSQAVGLPPWLQDPELMLLPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  83 KLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNR 162
Cdd:cd22799   81 KLISKYNWIKQWKLGLKFDGKNEDLVDKLKEYLTLLKKKWAGLAEMRTAEERQIACDELFTNEAEEYSLYEAVKFLMLNR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 163 AIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY 242
Cdd:cd22799  161 AIELYNDKEKGKEVPFFSWLLFARDTSNNPGQLLRNHLNQVGHSGGLEQVEMFLLGYALQHTIQVYRLYKYNTEEFITVY 240
                        250       260
                 ....*....|....*....|....*.
gi 514829648 243 PTDPPKDWPVVTLIAEADRHYNIPVR 268
Cdd:cd22799  241 PTDPPKDWPVVTLITEDDRHYNIPVR 266
Peptidase_C101 pfam16218
Peptidase family C101; This is a family of cysteine-peptidases that is conserved in ...
3-267 3.45e-180

Peptidase family C101; This is a family of cysteine-peptidases that is conserved in vertebrates. The key residues as found in human OTULIN are Asp126, Cys129, His339 and Asn341.


Pssm-ID: 435225  Cd Length: 265  Bit Score: 496.07  E-value: 3.45e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648    3 LSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPE 82
Cdd:pfam16218   1 LSVAPEVDILDYSEREWRGNTAKAALMRKGYEEVSQKFSSLRRVRGDNYCALRATLFQILSQSTQLPSWLQDEDILMLPE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648   83 KLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNR 162
Cdd:pfam16218  81 KLLAKYNWIKQWTFPPECPYGGKNAVEKLKECLELLKTKWQEAVECKTHEERQSACDELFSGEEEEYKLYEALKFLMLNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  163 AIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY 242
Cdd:pfam16218 161 AIELYEDMEKGKEVPVFCWLLFARDTSSDPESFLMNHLNQVGDSGGLEQVEMFLLGYALEVTIQVYRLYKYNTEEFITYY 240
                         250       260
                  ....*....|....*....|....*
gi 514829648  243 PTDPPKDWPVVTLIAEADRHYNIPV 267
Cdd:pfam16218 241 PDDHRDDWPVVTLITEDDRHYNVPV 265
 
Name Accession Description Interval E-value
OTU_OTUL cd22799
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also ...
3-268 0e+00

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438620  Cd Length: 266  Bit Score: 517.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648   3 LSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPE 82
Cdd:cd22799    1 LSVAPEMDILDYCKKEWRGNTQKATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQALSQAVGLPPWLQDPELMLLPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  83 KLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNR 162
Cdd:cd22799   81 KLISKYNWIKQWKLGLKFDGKNEDLVDKLKEYLTLLKKKWAGLAEMRTAEERQIACDELFTNEAEEYSLYEAVKFLMLNR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 163 AIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY 242
Cdd:cd22799  161 AIELYNDKEKGKEVPFFSWLLFARDTSNNPGQLLRNHLNQVGHSGGLEQVEMFLLGYALQHTIQVYRLYKYNTEEFITVY 240
                        250       260
                 ....*....|....*....|....*.
gi 514829648 243 PTDPPKDWPVVTLIAEADRHYNIPVR 268
Cdd:cd22799  241 PTDPPKDWPVVTLITEDDRHYNIPVR 266
Peptidase_C101 pfam16218
Peptidase family C101; This is a family of cysteine-peptidases that is conserved in ...
3-267 3.45e-180

Peptidase family C101; This is a family of cysteine-peptidases that is conserved in vertebrates. The key residues as found in human OTULIN are Asp126, Cys129, His339 and Asn341.


Pssm-ID: 435225  Cd Length: 265  Bit Score: 496.07  E-value: 3.45e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648    3 LSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPE 82
Cdd:pfam16218   1 LSVAPEVDILDYSEREWRGNTAKAALMRKGYEEVSQKFSSLRRVRGDNYCALRATLFQILSQSTQLPSWLQDEDILMLPE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648   83 KLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNR 162
Cdd:pfam16218  81 KLLAKYNWIKQWTFPPECPYGGKNAVEKLKECLELLKTKWQEAVECKTHEERQSACDELFSGEEEEYKLYEALKFLMLNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  163 AIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY 242
Cdd:pfam16218 161 AIELYEDMEKGKEVPVFCWLLFARDTSSDPESFLMNHLNQVGDSGGLEQVEMFLLGYALEVTIQVYRLYKYNTEEFITYY 240
                         250       260
                  ....*....|....*....|....*
gi 514829648  243 PTDPPKDWPVVTLIAEADRHYNIPV 267
Cdd:pfam16218 241 PDDHRDDWPVVTLITEDDRHYNVPV 265
OTU_OTUL-like cd22790
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin family; Otulin family includes ...
13-267 2.56e-136

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin family; Otulin family includes otulin and otulinl. Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulinl, also called FAM105A, is an OTU-class pseudo-deubiquitinase with a disrupted catalytic triad and undetectable cleavage activity for any diubiquitin linkage. It may play a role in endoplasmic reticulum (ER)-organelle communication. Otulin and otulinl belong to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438611  Cd Length: 258  Bit Score: 384.65  E-value: 2.56e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  13 DYCKKEWRGNTQKATCMKMGYEEVSQK--FTSIRRVRGDNYCALRATLFQAMSQAVGLPPWlqDPELMLLPEKLISKY-- 88
Cdd:cd22790    1 DYAEREWKGETPKAKTIKKGYEEIPRLlgCKYLRRIRGDNYCAIRAALFQVLSQGIPVPSK--WPALEQIPEKLLNSYgc 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  89 NWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNE-AEEYSLYEAVKFLMLNRAIELY 167
Cdd:cd22790   79 SWLQQWSFANRLPYTGEDVLSGLRECLLTLDSQVEELESMSTEEDREDALLSLLNSDpTLDLKLMEAVKLLMLVSAIELY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 168 NDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPP 247
Cdd:cd22790  159 NRMQKGEDVPLFAWLLFARDTSSTPKDFLKNHLNPVGDTAGLEQVEMFLLGYSLGVTIRVFRPSQFGQEDFICYYPDEED 238
                        250       260
                 ....*....|....*....|
gi 514829648 248 KDWPVVTLIAEADRHYNIPV 267
Cdd:cd22790  239 DDWPEVTLIAEDDRHYNVPV 258
OTU_OTULL cd22798
OTU (ovarian tumor) domain of inactive ubiquitin thioesterase Otulinl; Otulinl, also called ...
10-267 6.85e-99

OTU (ovarian tumor) domain of inactive ubiquitin thioesterase Otulinl; Otulinl, also called FAM105A, is an OTU-class pseudo-deubiquitinase with a disrupted catalytic triad and undetectable cleavage activity for any diubiquitin linkage. It may play a role in endoplasmic reticulum (ER)-organelle communication. Otulinl belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438619  Cd Length: 261  Bit Score: 290.17  E-value: 6.85e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  10 DIMDYCKKEWRGNTQKATCMKMGYEEVSQK--FTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPEKLISK 87
Cdd:cd22798    1 DLLEYCAREWKGETPRAKQMRKAYEELFWRhhIKYVRQVRGDNYCALRAVLFQIFSQGIPFPSWMKEQDILKLPEKLLYS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  88 Y--NWIKQWKLGL-KFDGKNedLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAI 164
Cdd:cd22798   81 QgcNWIQQYSFGPeKYTGPN--VFGKLRKCVETLKTQWTEISGIKDYEKRGKMCNTLFSDEAKEYKLYEAIKFLMLYQVI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 165 ELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPT 244
Cdd:cd22798  159 EVYEQMKTGQDVPNFFSLLFSRDTSSDPLSFMMNHLNSIGDTGGLEQIEMFLLGYTLEVKIKVFRLYKFNTEEFEVCYPE 238
                        250       260
                 ....*....|....*....|...
gi 514829648 245 DPPKDWPVVTLIAEADRHYNIPV 267
Cdd:cd22798  239 EYLRDWPEISLLTEDDRHYNIPV 261
Otubain_C65 cd22749
Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 ...
37-265 1.32e-07

Otubain subfamily of ubiquitin thioesterases; The otubain subfamily is composed of otubain-1 (also called ubiquitin thioesterase OTUB1 or OTU domain-containing ubiquitin aldehyde-binding protein 1), otubain-2 (also called ubiquitin thioesterase OTUB2 or OTU domain-containing ubiquitin aldehyde-binding protein 2), and similar proteins. They function as deubiquitylases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12). OTUB1 can specifically remove 'Lys-48'-linked conjugated ubiquitin from protein substrates, while OTUB2 mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. The otubain subfamily belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. Members of this subfamily are classified as family C65 cysteine proteases by MEROPS.


Pssm-ID: 438586 [Multi-domain]  Cd Length: 232  Bit Score: 51.18  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648  37 SQKFTSIRRVRGDNYCALRATLFQAMSQavglppwLQDPELMLLPEKLISKynwIKQWKLGLKFDGKNEDLVDKIKESLT 116
Cdd:cd22749   29 KKKYSGFRRVRGDGNCFYRAFAFSYLEL-------LLKNQDPAELERLLAR---LESLKNLLEALGFEELVFEDFYEEFL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 117 LLrkkwagLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAIELYNDKEkgKEVPFFsvllfarDTSNDPGQLL 196
Cdd:cd22749   99 EL------LKKLRNSKERELTEEELLELFNDEETSNYIVVFLRLLTSAYLKTNAD--DYEPFL-------FEGMSVEEFC 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514829648 197 RNHLNQVGHTGglEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITV-YPTDPPKDWPVVTLIAeadR--HYNI 265
Cdd:cd22749  164 EREVEPMGKEA--DHLQITALANALGVPVRVEYLDRSAGGEVNFHeFPPEDSDSLPVITLLY---RpgHYDI 230
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
178-265 9.68e-03

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 35.49  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514829648 178 FFSVLLFARDTSNDPGQLLRNhLNQVGHTGGleQVEMFLLAYAVRHTIQVYrlSKYNTEEFITVYPTDPPKDWPVVTLIA 257
Cdd:cd22744   45 YEPAELADEDDGEDFDEYLQR-MRKPGTWGG--ELELQALANALNVPIVVY--SEDGGFLPVSVFGPGPGPSGRPIHLLY 119

                 ....*...
gi 514829648 258 EADRHYNI 265
Cdd:cd22744  120 TGGNHYDA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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