NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|51773477|emb|CAF25308|]
View 

N-terminal acetyltransferase complex ARD1 subunit homolog, partial [Mus musculus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 49-147 6.34e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 6.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  49 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLYSNtLNFQISEV 128
Cdd:COG0456   1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYEK-LGFEEVGE 75

                        90
                ....*....|....*....
gi 51773477 129 EPKYYADgeDAYAMKRDLT 147
Cdd:COG0456  76 RPNYYGD--DALVMEKELA 92
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 49-147 6.34e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 6.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  49 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLYSNtLNFQISEV 128
Cdd:COG0456   1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYEK-LGFEEVGE 75

                        90
                ....*....|....*....
gi 51773477 129 EPKYYADgeDAYAMKRDLT 147
Cdd:COG0456  76 RPNYYGD--DALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 23-117 2.14e-16

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 72.55  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477    23 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 102
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96

                          90
                  ....*....|....*
gi 51773477   103 SLHVRKSNRAALHLY 117
Cdd:pfam00583  97 FLEVAADNLAAIALY 111
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 37-105 1.09e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 1.09e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51773477  37 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 105
Cdd:cd04301   1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 34-128 2.13e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477   34 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRKSNRAA 113
Cdd:PRK03624  44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVREDNDAV 116

                         90
                 ....*....|....*
gi 51773477  114 LHLYSnTLNFQISEV 128
Cdd:PRK03624 117 LGFYE-ALGYEEQDR 130
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 49-147 6.34e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 6.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  49 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLYSNtLNFQISEV 128
Cdd:COG0456   1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYEK-LGFEEVGE 75

                        90
                ....*....|....*....
gi 51773477 129 EPKYYADgeDAYAMKRDLT 147
Cdd:COG0456  76 RPNYYGD--DALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 23-117 2.14e-16

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 72.55  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477    23 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 102
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96

                          90
                  ....*....|....*
gi 51773477   103 SLHVRKSNRAALHLY 117
Cdd:pfam00583  97 FLEVAADNLAAIALY 111
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
34-146 3.06e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 59.33  E-value: 3.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  34 PQLSYIAEDeNGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHvrkSNRAA 113
Cdd:COG3153  38 AGLSLVAED-DGEIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARER-GARAVVLL---GDPSL 112

                        90       100       110
                ....*....|....*....|....*....|...
gi 51773477 114 LHLYSNtLNFQisEVEPKYYADGEDAYAMKRDL 146
Cdd:COG3153 113 LPFYER-FGFR--PAGELGLTLGPDEVFLAKEL 142
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 37-105 1.09e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 1.09e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51773477  37 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 105
Cdd:cd04301   1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 38-117 1.41e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.53  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477    38 YIAEDeNGKIVGYVLAKMEEDPDDVPHGHItslAVKRSHRRLGLAQKLMDQASRAMienfNAKYVSLHVRKSNRAALHLY 117
Cdd:pfam13508   6 FVAED-DGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRALLEAAEAAA----KEGGIKLLELETTNRAAAFY 77
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 38-146 1.95e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 51.15  E-value: 1.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  38 YIAEdENGKIVGYV-LAKMEEDpddvpHGHITSLAVKRSHRRLGLAQKLMDQA-SRAmiENFNAKYVSLHvrkSNRAALH 115
Cdd:COG1246  31 WVAE-EDGEIVGCAaLHPLDED-----LAELRSLAVHPDYRGRGIGRRLLEALlAEA--RELGLKRLFLL---TTSAAIH 99

                        90       100       110
                ....*....|....*....|....*....|...
gi 51773477 116 LYSNtLNFQISEVE--PKYYADGEDAYAMKRDL 146
Cdd:COG1246 100 FYEK-LGFEEIDKEdlPYAKVWQRDSVVMEKDL 131
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
38-146 2.46e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 51.53  E-value: 2.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  38 YIAEdENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 117
Cdd:COG1247  55 LVAE-EDGEVVGFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARAR-GYRRLVAVVLADNEASIALY 132

                        90       100       110
                ....*....|....*....|....*....|..
gi 51773477 118 SNtLNFQISEVEPK-YYADGE--DAYAMKRDL 146
Cdd:COG1247 133 EK-LGFEEVGTLPEvGFKFGRwlDLVLMQKRL 163
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
51-117 1.50e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 47.60  E-value: 1.50e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51773477  51 VLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 117
Cdd:COG3393   2 LVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALAR-GARTPFLYVDADNPAARRLY 67
PRK03624 PRK03624
putative acetyltransferase; Provisional
 34-128 2.13e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477   34 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRKSNRAA 113
Cdd:PRK03624  44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVREDNDAV 116

                         90
                 ....*....|....*
gi 51773477  114 LHLYSnTLNFQISEV 128
Cdd:PRK03624 117 LGFYE-ALGYEEQDR 130
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
43-147 4.63e-06

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 44.79  E-value: 4.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477  43 ENGKIVGY--VLakmeedPDDVPHGHITSLAVKRSHRRLGLAQKLMdQASRAMIENFNAKYVSLHVRKSnraALHLYSNt 120
Cdd:COG2153  41 DDGELVATarLL------PPGDGEAKIGRVAVLPEYRGQGLGRALM-EAAIEEARERGARRIVLSAQAH---AVGFYEK- 109

                        90       100
                ....*....|....*....|....*...
gi 51773477 121 LNFQ-ISEVepkYYADGEDAYAMKRDLT 147
Cdd:COG2153 110 LGFVpVGEE---FLEAGIPHIDMRKPLS 134
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 70-142 1.44e-05

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 43.38  E-value: 1.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51773477   70 LAVKRSHRRLGLAQKLMdqasRAMIENFNAKYVS---LHVRKSNRAALHLYSNtLNFQISEVEPKYY--ADG-EDAYAM 142
Cdd:PRK09491  69 IAVDPDYQRQGLGRALL----EHLIDELEKRGVAtlwLEVRASNAAAIALYES-LGFNEVTIRRNYYptADGrEDAIIM 142
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 63-124 3.47e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 38.46  E-value: 3.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51773477    63 PHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnfNAKYVSLHVRKSNRAALHLYSNtLNFQ 124
Cdd:pfam08445  20 PGGELGALQTLPEHRRRGLGSRLVAALARGIAE--RGITPFAVVVAGNTPSRRLYEK-LGFR 78
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 42-105 3.67e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 39.18  E-value: 3.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51773477    42 DENGKIVGYVLAKMeedpddvpHGHITSLAVKRSHRRLGLAQKLMDQA-SRAMIENFNAKYVSLH 105
Cdd:pfam13673  37 FEGGQIVGVIALRD--------RGHISLLFVDPDYQGQGIGKALLEAVeDYAEKDGIKLSELTVN 93
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 39-117 5.75e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 39.21  E-value: 5.75e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51773477  39 IAEDENGKIVGYVLAkMEEDPDDvPHGHItSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLY 117
Cdd:COG1670  65 IEDKEDGELIGVVGL-YDIDRAN-RSAEI-GYWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVL 140
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
39-117 2.79e-03

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 37.60  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51773477   39 IAEDENGKIVGYVLAKMEEDPDdvphGHITSLAVKRSHRRLGLAQKLMdQASRAMIENFNAKyvSLHV--RKSNRAALHL 116
Cdd:PRK10975 105 LLRDASGQIQGFVTLRELNDTD----ARIGLLAVFPGAQGRGIGARLM-QAALNWCQARGLT--RLRVatQMGNLAALRL 177


                 .
gi 51773477  117 Y 117
Cdd:PRK10975 178 Y 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH