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Conserved domains on  [gi|528968953|ref|XP_005212896|]
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prokineticin receptor 1 isoform X1 [Bos taurus]

Protein Classification

7tmA_prokineticin-R domain-containing protein( domain architecture ID 11606947)

7tmA_prokineticin-R domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-387 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


:

Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 524.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVivkSQEKIFCGQIWP 256
Cdd:cd15204   81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15204  158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 337 FAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15204  238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-387 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 524.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVivkSQEKIFCGQIWP 256
Cdd:cd15204   81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15204  158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 337 FAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15204  238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
113-372 1.07e-53

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 179.42  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLHG-DWPFGSALCKLVGALFYVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  193 AIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQQiYYKSYFLFI 270
Cdd:pfam00001  80 SIDRYLAIVHPLRyrRIRTPRRAKVLILLVWVLALLLSLPPLLFGW---TLTVPEGNVTVCFIDFPEVLS-KPVSYTLLS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  271 FGIEFVGPVVTMTLCYARISRELWFKAVPGfqtEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVK 350
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTRIIRTLRKSASKQ---KSEERTQRRERKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 232
                         250       260
                  ....*....|....*....|..
gi 528968953  351 EKHYlTAFYVVECIAMSNSMIN 372
Cdd:pfam00001 233 RLLD-KALSITLWLAYVNSCLN 253
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
71-398 5.96e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.14  E-value: 5.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  71 FSYGDYDMPLDED-EDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALARYKkLRNLTNLLIANLAISDfLVAIVC 149
Cdd:PHA03087  14 TTDYYYDTYYDEDyADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSD-LLFVMT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 150 CPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILV 227
Cdd:PHA03087  92 LPFQIYYYILFQWSF--GEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKsnKINTVKYGYIVSLVIWIISIIE 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 228 AIPSAYFTTetvlviVKSQEKIFCGQIWPVDQQIYYKSYFLF---IFGieFVGPVVTMTLCYARISRELwfkavpgfQTE 304
Cdd:PHA03087 170 TTPILFVYT------TKKDHETLICCMFYNNKTMNWKLFINFeinIIG--MLIPLTILLYCYSKILITL--------KGI 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 305 QIRKRlrcRRKTVLVLMCILTAYVLCWAPFYgfaivrdffPTVFVKEKHYLT-------------AFYVVECIAMSNSMI 371
Cdd:PHA03087 234 NKSKK---NKKAIKLVLIIVILFVIFWLPFN---------VSVFVYSLHILHfksgckavkyiqyALHVTEIISLSHCCI 301
                        330       340
                 ....*....|....*....|....*..
gi 528968953 372 NTVCFVTVKNNTIKYFKKIMLLHWKAS 398
Cdd:PHA03087 302 NPLIYAFVSEFFNKHKKKSLKLMFTSS 328
 
Name Accession Description Interval E-value
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-387 0e+00

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 524.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQRSWTHGDVLCAVVNY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVivkSQEKIFCGQIWP 256
Cdd:cd15204   81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA---NQGKIFCGQIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15204  158 VDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 337 FAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15204  238 YAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
97-387 1.36e-124

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 362.52  E-value: 1.36e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSL--SWEYGHFLCKIVNY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQI 254
Cdd:cd14992   79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQ-TEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd14992  159 PPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSiKEVERKRLKCKRRVIKMLVCVVVLFVICWLP 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 334 FYGFAIVRDFFPTvFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd14992  239 FHLFFLLRDFFPL-IMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
105-372 1.79e-63

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 205.92  E-value: 1.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15203    8 GLIIVLGVvGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKN--WPFGSILCKLVPSLQGVSIF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTT-ETVLVIVKSQEKIFCGQIWPvdQQIY 262
Cdd:cd15203   86 VSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQElSDVPIEILPYCGYFCTESWP--SSSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISREL---WFK--AVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGF 337
Cdd:cd15203  164 RLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrVKKkrGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLF 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 528968953 338 AIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15203  244 NLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVN 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
97-387 7.71e-61

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 199.36  E-value: 7.71e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR--PWVFGEVLCKAVPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYF--TTETVLVIVKSQEKIFCG 252
Cdd:cd14993   79 LQGVSVSASVLTLVAISIDRYLAICYPLKARRVStkRRARIIIVAIWVIAIIIMLPLLVVyeLEEIISSEPGTITIYICT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQT----EQIRKRLRCRRKTVLVLMCILTAYV 328
Cdd:cd14993  159 EDWP--SPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGsansTSSRRILRSKKKVARMLIVVVVLFA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 329 LCWAPFYGFAIVRDFFPTVFVKEKH-YLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd14993  237 LSWLPYYVLSILLDFGPLSSEESDEnFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
97-372 3.79e-55

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 184.10  E-value: 3.79e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSF-IALLILQYWPFGEFMCPVVNY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15392   80 LQAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIA-ITSRLFEDSNASCGQYICTESWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIfgIEFVGPVVTMTLCYARISRELWFKAVPGFQTE-QIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15392  159 SDTNRYIYSLVLMI--LQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENnRDQRMAESKRKLVKMMITVVAIFALCWLPLN 236
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528968953 336 GFAIVRDFFPTVFvKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15392  237 ILNLVGDHDESIY-SWPYIPYLWLAAHWLAMSHCCYN 272
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
113-372 1.07e-53

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 179.42  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLHG-DWPFGSALCKLVGALFYVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  193 AIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQQiYYKSYFLFI 270
Cdd:pfam00001  80 SIDRYLAIVHPLRyrRIRTPRRAKVLILLVWVLALLLSLPPLLFGW---TLTVPEGNVTVCFIDFPEVLS-KPVSYTLLS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  271 FGIEFVGPVVTMTLCYARISRELWFKAVPGfqtEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVK 350
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTRIIRTLRKSASKQ---KSEERTQRRERKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 232
                         250       260
                  ....*....|....*....|..
gi 528968953  351 EKHYlTAFYVVECIAMSNSMIN 372
Cdd:pfam00001 233 RLLD-KALSITLWLAYVNSCLN 253
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
102-372 1.20e-53

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 179.79  E-value: 1.20e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVS 181
Cdd:cd00637    4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLG--RWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSAYFTTetvlvivKSQEKIFCGQIWPVDQ 259
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYrrRFTRRRAKLLIALIWLLSLLLALPPLLGWG-------VYDYGGYCCCCLCWPD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGF---QTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd00637  155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528968953 337 FAIVRDFFPTVFvkeKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd00637  235 LLLLDVFGPDPS---PLPRILYFLALLLAYLNSAIN 267
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
100-372 7.56e-50

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 170.55  E-value: 7.56e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFeMDYYVVRQlSWEHGHVLCASVNYLRT 179
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVF-NFTYLLYN-DWPFGLFYCKFSNFVAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQ 259
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFIAWPDGP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKS-YFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFA 338
Cdd:cd15390  162 NSLQDFvYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYF 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 528968953 339 IVRDFFPTVFVKeKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15390  242 ILTYLYPDINSW-KYIQQIYLAIYWLAMSNSMYN 274
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
97-372 4.41e-49

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 168.57  E-value: 4.41e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNY 176
Cdd:cd15207    1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNIL--TGWPFGDVMCKLSPL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15207   79 VQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDqqIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG---FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15207  159 SD--EYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGggsASREAQAAVSKKKVRVIKMLIVVVVLFALSWLP 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 528968953 334 FYGFAIVRDFFPtVFVKEKH--YLTAFYVVECIAMSNSMIN 372
Cdd:cd15207  237 LHTVTMLDDFGN-LSPNQREvlYVYIYPIAHWLAYFNSCVN 276
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
97-372 4.04e-46

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 160.75  E-value: 4.04e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT--WIFGLFMCHFSNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15202   79 AQYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15202  159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGdATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528968953 336 GFAIVRDFFPTVFVKEKHYLtaFYVVECIAMSNSMIN 372
Cdd:cd15202  239 IYVLLLSSKPDYLIKTINAV--YFAFHWLAMSSTCYN 273
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
106-372 1.85e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 153.74  E-value: 1.85e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15394   10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTL-AYAFEPRGWVFGRFMCYFVFLMQPVTVYVS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAyftTETVLVIVKSQEKIFCGQIW---PVDQQIY 262
Cdd:cd15394   89 VFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAA---AHTYYVEFKGLDFSICEEFWfgqEKQRLAY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 ykSYFLFIfgIEFVGPVVTMTLCYARISRELWFKAVPGFQTE-QIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVR 341
Cdd:cd15394  166 --ACSTLL--ITYVLPLLAISLSYLRISVKLRNRVVPGSMTQsQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIR 241
                        250       260       270
                 ....*....|....*....|....*....|.
gi 528968953 342 DFFPTvFVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15394  242 DIDID-LIDKQYFNLIQLLCHWLAMSSACYN 271
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
97-372 1.34e-41

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 148.64  E-value: 1.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNST--WVFGKIMCHLSRF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15389   79 AQYCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWF-KAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15389  159 EPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLrNAIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLN 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528968953 336 GFAIVRDFFPTvfvkeKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15389  239 CYHVLLSSHPI-----RSNSALFFAFHWLAMSSTCYN 270
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
98-372 6.07e-39

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 140.78  E-value: 6.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYL 177
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLG--YWPFGPVLCRFWIAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQIW 255
Cdd:cd14967   79 DVLCCTASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPPLVGWR------DETQPSVVDCECE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 PVDQQIYYksyfLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfQTEqirkrlrcrRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd14967  153 FTPNKIYV----LVSSVISFFIPLLIMIVLYARIFRVA--------RRE---------LKAAKTLAIIVGAFLLCWLPFF 211
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528968953 336 GFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMIN 372
Cdd:cd14967  212 IIYLVSAFCPPDCVPP----ILYAVFFWLGYLNSALN 244
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
98-389 7.58e-39

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 141.28  E-value: 7.58e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd14970    1 IVIPAVYSVVCVVGlTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLG--YWPFGEVMCKIVLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQ 253
Cdd:cd14970   78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVK-SLRFRTprkAKLVSLCVWALSLVLGLPVIIFAR----TLQEEGGTISCNL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAV-PGFQTEQIRKRLRCRRKTVLVLMcILTAYVLCWA 332
Cdd:cd14970  153 QWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRL--RSSrNLSTSGAREKRRARRKVTRLVLV-VVAVFVVCWL 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 333 PFYGFAIVR---DFFPTVFVkekhyLTAFYVVECIAMSNSMINTVCFVTVKNNtikyFKK 389
Cdd:cd14970  230 PFHVFQIVRlliDPPETLTV-----VGVFLFCIALSYANSCLNPILYAFLDEN----FRK 280
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
105-372 9.40e-39

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 141.01  E-value: 9.40e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15393    9 IISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQ--RWVLPRFMCPFCPFVQVLSVNV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSA-YFTTETVLVIVKSQEKIFCGQIWPVDQQiyY 263
Cdd:cd15393   87 SVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVAlALRVEELTDKTNNGVKPFCLPVGPSDDW--W 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRD 342
Cdd:cd15393  165 KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGnAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLNE 244
                        250       260       270
                 ....*....|....*....|....*....|
gi 528968953 343 FFPTVfVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15393  245 IKPEI-NKYKYINIIWFCSHWLAMSNSCYN 273
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-374 3.61e-38

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 139.83  E-value: 3.61e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCgignfifiAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15208    9 LVFIVGLVGNVLVC--------FAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTE--TWFFGQVLCKIIPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFtTETVLVIVKSQEKI---FCGQ 253
Cdd:cd15208   79 LQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIV-MECSRVVPLANKTIlltVCDE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIR--------------KRLRCRRKTVLV 319
Cdd:cd15208  158 RWS--DSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRkwnkprksavaaeeKQLRSRRKTAKM 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 320 LMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTV 374
Cdd:cd15208  236 LIVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPI 290
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
106-387 4.66e-38

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 139.34  E-value: 4.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15095   10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYAT--PSWVFGDFMCKFVNYMMQVTVQAT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSAYFTteTVLVIVKSQEKIFCGQIWPVDQqiY 262
Cdd:cd15095   88 CLTLTALSVDRYYAIVHPIR-SLRFRTprvAVVVSACIWIVSFLLSIPVAIYY--RLEEGYWYGPQTYCREVWPSKA--F 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQI--RKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIV 340
Cdd:cd15095  163 QKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQlsERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLW 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 341 RDFFPtvfvkEKHYLTAFYVVE----CIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15095  243 QRFDP-----NFPETYATYALKiaalCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
97-387 9.00e-38

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 138.41  E-value: 9.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDE--WKFGAVLCHLVPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15399   79 AQALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15399  159 NGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQR---RRKTTKMLVCVVVVFAVSWLPFHA 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 337 FAIVRDFFPTVFvKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15399  236 FQLASDIDSKVL-DLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
106-387 1.36e-36

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 135.68  E-value: 1.36e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15205   10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSN--WLGGAFMCKMVPFVQSTAVVTS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYF-TTETVLVIVKSQEKIFCGQIWpvDQQIY 262
Cdd:cd15205   88 ILTMTCIAVERHQGIVHPLKMKWQYtnRRAFTMLGLVWIVSVIVGSPMLFVqQLEVKYDFLYEKRHVCCLERW--YSPTQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWFK----------AVPGFQTEQIrkrLRCRRKTVLVLMCILTAYVLCWA 332
Cdd:cd15205  166 QKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKkrvgdasvlqTIHGIEMSKI---SRKKKRAVKMMVTVVLLFAVCWA 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 333 PFYGFAIVRDFfpTVFVKEKHYLTA---FYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15205  243 PFHVVHMMIEY--SNLENKYDGVTIkliFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
113-376 1.80e-36

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 134.95  E-value: 1.80e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:cd15391   17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH--WVFPAPMCPIVLYVQLVSVTASVLTNTAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAiPSAYFTTETVLVIVKSQEKIFCGQIWPvdQQIYYKS-YFLFIF 271
Cdd:cd15391   95 GIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLS-SVQLFAGRTQRYGQYSEGRVLCGESWP--GPDTSRSaYTVFVM 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 272 GIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQI-RKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDfFPTVFVK 350
Cdd:cd15391  172 LLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRdDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQD-FSTVFRN 250
                        250       260
                 ....*....|....*....|....*...
gi 528968953 351 EKHYLT--AFYVVECIAMSNSMINTVCF 376
Cdd:cd15391  251 MPQHTTrlIYGACHWIAMSNSFVNPIIY 278
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
106-387 2.87e-36

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 134.13  E-value: 2.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd14971   10 IFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLP--GWVFGDFMCKFVHYFQQVSMHAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYFTTETVlviVKSQEKIFCGQIWPvdQQIYY 263
Cdd:cd14971   88 IFTLVAMSLDRFLAVVYPLRSLHIRtpRNALAASGCIWVVSLAVAAPVLALHRLRN---YTPGNRTVCSEAWP--SRAHR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRkrlRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd14971  163 RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR---RAKRKVTRLVLVVVVLFAACWGPIHAILLLVAL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 344 FPTVFVKEKHYLTAFyvVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd14971  240 GPFPLTYATYALRIW--AHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
106-376 4.92e-36

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 133.17  E-value: 4.92e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVrqLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15001    9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFS--PTWSLGAFLCKAVAYLQLLSFICS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPlrprMKYQTATGL------IALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPvdQ 259
Cdd:cd15001   87 VLTLTAISIERYYVILHP----MKAKSFCTIgrarkvALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWP--S 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISrelwfkavpgfqteqirkrlrcRRKTVLVLMCILTAYVLCWAPF--YGF 337
Cdd:cd15001  161 TLYSRLYVVYLAIVIFFIPLIVMTFAYARDT----------------------RKQVIKMLISVVVLFAVCWGPLliDNL 218
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528968953 338 AIVRDFFPTVFVKEKHYLTAFYvvECIAMSNSMINTVCF 376
Cdd:cd15001  219 LVSFDVISTLHTQALKYMRIAF--HLLSYANSCINPIIY 255
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
102-376 2.23e-35

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 132.11  E-value: 2.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVS 181
Cdd:cd14986    6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGE--WVAGDVLCRIVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAY-FTTETVLVIVKSqekifCGQIWPvdQQ 260
Cdd:cd14986   84 LFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLViFVERELGDGVHQ-----CWSSFY--TP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 IYYKSYFLFIFGIEFVGPVVTMTLCYARISRELW-----FKAVPGFQTEQIRKRLRCRR-----------KTVLVLMCIL 324
Cdd:cd14986  157 WQRKVYITWLATYVFVIPLIILSYCYGRILRTIWirsrqKTDRPIAPTAMSCRSVSCVSsrvslisrakiKTIKMTLVII 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528968953 325 TAYVLCWAPFYGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd14986  237 LAFILCWTPYFIVQLLDVYAGMQQLEN----DAYVVSETLASLNSALNPLIY 284
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
98-389 1.37e-33

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 127.15  E-value: 1.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKL--RNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASV 174
Cdd:cd15098    1 VIVPVVFGLIFCLGVlGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLP--EWVFGAFMCKFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTtetvlVIVKSQEK---I 249
Cdd:cd15098   79 HYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSslRTRRNALLGVLVIWVLSLAMASPVAVHQ-----DLVHHWTAsnqT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGQIWPVDQQiyYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAvpgfqTEQIRKRLRCRRKTVLVLMCILTAYVL 329
Cdd:cd15098  154 FCWENWPEKQQ--KPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKL-----KNMSKKSERSKKKTAQTVLVVVVVFGI 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 330 CWAPFYGFAIVRDF--FPtvfvkekhYLTAFYVVE----CIAMSNSMINTVCFVTVKNNtikyFKK 389
Cdd:cd15098  227 SWLPHHIIHLWVEFgdFP--------LTQASFVLRitahCLAYANSCVNPIIYAFLSEN----FRK 280
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
101-376 6.23e-33

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 125.43  E-value: 6.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 180
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSE--WYFGEAYCRFHNFFPIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLvivksQEKIFCGQIWPVDQQ 260
Cdd:cd16003   83 SVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVM-----PGRTLCFVAWPGGPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 IYYKSYFLFIFgIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIV 340
Cdd:cd16003  158 QHFTYHIIVIV-LVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIV 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528968953 341 RDFFPTVfVKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd16003  237 TGLYQQL-NRWKYIQQVYLASFWLAMSSTMYNPIIY 271
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
106-374 3.33e-32

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 123.53  E-value: 3.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15927   10 IFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLD--SWPFGEFLCKLSEFLKDTSIGVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLI--ALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCgQIWPVDQQIYY 263
Cdd:cd15927   88 VFTLTALSADRYFAIVNPMRKHRSQATRRTLVtaASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIC-YPYPQELGPNY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 -KSYFLFIFGIEFVGPVVTMTLCYARISRELW--FKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIV 340
Cdd:cd15927  167 pKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLW 246
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 528968953 341 RDFFPTVFVKEKHYLTAFYVVE-CIAMSNSMINTV 374
Cdd:cd15927  247 FHFAPNGLVDYNAFWHVLKIVGfCLSFINSCVNPV 281
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
106-389 1.12e-30

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 119.46  E-value: 1.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFE-----MDYyvvrqlsWEHGHVLCASVNYLRT 179
Cdd:cd15397    9 LVMAVGlLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTvvytlMDY-------WIFGEVLCKMTPFIQC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTET-------VLVIVKSQEKIFCG 252
Cdd:cd15397   82 MSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTdepyknlSHFFAPLADKAVCT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQQ--IYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLC 330
Cdd:cd15397  162 ESWPSEHHklAYTTWLLLFQYCL----PLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKRINVMLVSLVAAFALC 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 331 WAPFYGFAIVRDFFPTVFVKEKHYLTaFYVVECIAMSNSMINTVCFVTVKNNtikyFKK 389
Cdd:cd15397  238 WLPLNVFNAIADWNHEAIPHCQHNLI-FSLCHLAAMASTCVNPIIYGFLNSN----FKK 291
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
106-376 1.36e-30

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 118.65  E-value: 1.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 185
Cdd:cd15206   10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIF--GEVMCKLIPYFQAVSVSVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRmKYQT---ATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPvdQQIY 262
Cdd:cd15206   88 TFTLVAISLERYFAICHPLKSR-VWQTlshAYKVIAGIWLLSFLIMSPILVFSN---LIPMSRPGGHKCREVWP--NEIA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirkrlRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRD 342
Cdd:cd15206  162 EQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL----------------EAKKRVIRMLFVIVVEFFICWTPLYVINTWKA 225
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528968953 343 FFPTVfVKEKHYLTAFYVVECIAMSNSMIN--TVCF 376
Cdd:cd15206  226 FDPPS-AARYVSSTTISLIQLLAYISSCVNpiTYCF 260
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
112-380 4.10e-30

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 117.32  E-value: 4.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVrqlSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd14984   16 VGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAAD---GWVFGSFLCKLVSALYTINFYSGILFLAC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPL----RPRMKYQTATGLIalVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCGQIWPVDQQIYYKSYF 267
Cdd:cd14984   92 ISIDRYLAIVHAVsalrARTLLHGKLTCLG--VWALALLLSLPEFIFSQ-----VSEENGSSICSYDYPEDTATTWKTLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 268 LF---IFGieFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFF 344
Cdd:cd14984  165 RLlqnILG--FLLPLLVMLFCYSRIIRTL------------LRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQ 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528968953 345 PTVFVK-----EKHYLTAFYVVECIAMSNSMINTV--CFVTVK 380
Cdd:cd14984  231 LLGIISrscelSKSLDYALQVTESLAFSHCCLNPVlyAFVGVK 273
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
106-376 8.71e-30

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 116.89  E-value: 8.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd16002   10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNE--WYYGLEYCKFHNFFPIAAVFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLvivksQEKIFCGQIWP-VDQQIYYK 264
Cdd:cd16002   88 IYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEM-----PGRVVCYVEWPeHEERKYET 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFF 344
Cdd:cd16002  163 VYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFH 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 528968953 345 PTVFVKeKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd16002  243 PELYEQ-KFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
98-372 1.42e-29

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 116.24  E-value: 1.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGN-FIFIAALARyKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVN 175
Cdd:cd15096    1 IVVPVIFGLIFIVGlIGNsLVILVVLSN-QQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPT--WPFGDVWCKIVQ 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCGQ 253
Cdd:cd15096   78 YLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVL-FLHGVVSYGFSSEAYSYCTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQ--QIYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAVPGFQ--TEQIRKRLRCRRKTVLVLMciltAYVL 329
Cdd:cd15096  157 LTEVGTaaQTFFTSFFLFSYLI----PLTLICVLYMLMLRRLRRQKSPGGRrsAESQRGKRRVTRLVVVVVV----VFAI 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 330 CWAPfygfaIVRDFFPTVFVKEKHylTAFYVV-----ECIAMSNSMIN 372
Cdd:cd15096  229 CWLP-----IHIILLLKYYGVLPE--TVLYVViqilsNCLAYGNSCVN 269
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
106-376 4.93e-29

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 114.94  E-value: 4.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYyvVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd16004   10 IVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVY--ASHNDWYFGLEFCRFQNFFPITAMFVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCGQIWPVDQQIYYK- 264
Cdd:cd16004   88 IYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYST-----VTMDQGRTKCIVAWPGDSGGKHQl 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQ-TEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd16004  163 TYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQaHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSF 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 528968953 344 FPTVFvKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd16004  243 NEDIY-CQKYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
98-382 1.11e-28

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 113.70  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFeMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15088    1 VIMPSVFGCICVVGlVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPF-LIHQFAIDGQWYFGEVMCKIITA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQ 253
Cdd:cd15088   79 LDANNQFTSTYILTAMSVDRYLAVVHPIR-STKYRTrfvAKLVNVGLWAASFLSILPVWVYSS----LIYFPDGTTFCYV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYARISRELWFKAVPGFQTeQIRKRLrcrRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15088  154 SLPSPDDLYWFTIYHFILG--FAVPLVVITVCYILILHRLARGVAPGNQS-HGSSRT---KRVTKMVILIVVVFIVCWLP 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 334 FYGFAIVR--DFFPTVfvkekHYLTAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd15088  228 FHVVQLVNlaMNRPTL-----AFEVAYFLSICLGYANSCLNPFVYILVSEN 273
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
106-381 1.75e-28

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 113.24  E-value: 1.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd14985   10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLPLWATYTA-NQYDWPFGAFLCKVSSYVISVNMFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQQIYY 263
Cdd:cd14985   88 IFLLTCMSVDRYLAIVHPVasRRLRRRRQARVTCALIWVVACLLSLPTFLLRS---LQAIENLNKTACIMLYPHEAWHFG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGieFVGPVVTMTLCYARISRELWFKavpgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFA----- 338
Cdd:cd14985  165 LSLELNILG--FVLPLLIILTCYFHIARSLRKR------YERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKfldfl 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 339 ----IVRDFFPTVFVKekhylTAFYVVECIAMSNSMINTVCFVTVKN 381
Cdd:cd14985  237 aqlgAIRPCFWELFLD-----LGLPIATCLAFTNSCLNPFIYVFVDR 278
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
106-345 3.60e-28

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 112.22  E-value: 3.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 185
Cdd:cd15979   10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIF--GEVICKAVAYLMGVSVSVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMkYQT---ATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQqiY 262
Cdd:cd15979   88 TFSLVAIAIERYSAICNPLQSRV-WQTrshAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPSAQ--V 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRD 342
Cdd:cd15979  165 RQAWYVLLLLILFFIPGVVMIVAYGLISRELY-------------RGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWRA 231

                 ...
gi 528968953 343 FFP 345
Cdd:cd15979  232 FDP 234
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
97-349 4.70e-28

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 111.91  E-value: 4.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNY 176
Cdd:cd14969    3 LAVYLSLIGVLGV--VLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSF--GDPGCVIYGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIP-----SAYfTTETVlvivksqeKIF 250
Cdd:cd14969   79 AVTFLGLVSISTLAALAFERYLVIVRPLKAfRLSKRRALILIAFIWLYGLFWALPplfgwSSY-VPEGG--------GTS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWpVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFK---AVPGFQTEQIRKRLRCRRKTVLVLMCILTAY 327
Cdd:cd14969  150 CSVDW-YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMskrAARRKNSAITKRTKKAEKKVAKMVLVMIVAF 228
                        250       260
                 ....*....|....*....|..
gi 528968953 328 VLCWAPFYGFAIVRDFFPTVFV 349
Cdd:cd14969  229 LIAWTPYAVVSLYVSFGGESTI 250
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
97-387 8.01e-28

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 111.16  E-value: 8.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRH--WPFGSLLCRLVLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR-PRMKYQTATGLIAL-VWVVSILVAIPSAYFTTETvlviVKSQEKIFCGQI 254
Cdd:cd15970   78 VDAINMFTSIYCLTVLSIDRYIAVVHPIKaARYRRPTVAKMVNLgVWVFSILVILPIIIFSNTA----PNSDGSVACNMQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAV-PGFQteqirKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15970  154 MPEPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALkAGWQ-----QRKRSERKITLMVMMVVTVFVICWMP 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 334 FYGFAIVrdffpTVFVkEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15970  229 FYVVQLV-----SVFV-GQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
108-387 5.34e-27

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 109.09  E-value: 5.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIG---NFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15093    9 VVCLVGlcgNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRH--WPFGSVLCRLVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIAL-VWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd15093   86 SIFCLTVMSVDRYLAVVHPIKSaRWRRPRVAKVVNLaVWVASLLVILPVVVFAG----TRENQDGSSACNMQWPEPAAAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAV-PGFQteqirKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVR 341
Cdd:cd15093  162 SAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLrAGWQ-----QRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVN 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 342 DFFPtvFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15093  237 VFVQ--LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
98-337 6.31e-27

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 108.65  E-value: 6.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALA--RYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVN 175
Cdd:cd15002    1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKG--SWPLGWFVCKTAD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR-MKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCGQI 254
Cdd:cd15002   79 WFGHACMAAKSFTIAVLAKACYMYVVNPTKQVtIKQRRITAVVASIWVPACLLPLPQWLFRT-----VKQSEGVYLCILC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPV----DQQIYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKavpGFQTEQIRKRLRCRRKTVLVLMcILTAYVLC 330
Cdd:cd15002  154 IPPlaheFMSAFVKLYPLFVFCL----PLTFALFYFWRAYGQCQRR---GTKTQNLRNQIRSRKLTHMLLS-VVLAFTIL 225

                 ....*..
gi 528968953 331 WAPFYGF 337
Cdd:cd15002  226 WLPEWVA 232
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
97-346 9.22e-27

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 108.66  E-value: 9.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVgIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd14977    2 VIMSLSLV-IFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKD--WLFGDVMCKLVPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCG-Q 253
Cdd:cd14977   79 IQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTigACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCImK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd14977  159 PSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEY--TRGTKKHMKQRRQLAKTVLCLVLVFAFCWLP 236
                        250
                 ....*....|...
gi 528968953 334 FYGFAIVRDFFPT 346
Cdd:cd14977  237 EHISNILRATLYN 249
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
97-374 1.80e-26

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 107.98  E-value: 1.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15395    1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDH--WVFGEAMCKLNSM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYF---TTETVLVIVKSQE----KI 249
Cdd:cd15395   79 VQCISITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFqvlTDEPFKNVNVSLDaykgKY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGQIWPVDQQIYykSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVL 329
Cdd:cd15395  159 VCLDQFPSDTIRL--SYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLISIVVAFAV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKEKHYLTaFYVVECIAMSNSMINTV 374
Cdd:cd15395  237 CWLPLNIFNAVFDWNHEAIATCNHNLL-FLICHLTAMISTCVNPI 280
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
106-380 2.67e-26

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 106.68  E-value: 2.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVrqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15182   10 VFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTF-TLPFWASYHSS---GWIFGEILCKAVTSIFYIGFYSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLR----PRMKYqtATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQIWPVDQQI 261
Cdd:cd15182   86 ILFLTLMTIDRYLAVVHPLSalrsRKLRY--ASLVSVAVWVISILASLPELILST----VMKSDEDGSLCEYSSIKWKLG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 262 YYKSYFLFifgieFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVR 341
Cdd:cd15182  160 YYYQQNLF-----FLIPLGIIVYCYVRILQTL------------MRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLR 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 342 DFFPTVFVKE---KHYLTAFYVVECIAMSNSMINTV--CFVTVK 380
Cdd:cd15182  223 SLKDLTIPICecsKQLDYAFYICRNIAFSHCCLNPVfyVFVGVK 266
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
106-343 3.85e-26

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 107.28  E-value: 3.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15980   10 IFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIA--GWPFGSTVCKMSGMVQGISVSAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFT----TETVLVIVKSQEKI----FCGQIWPv 257
Cdd:cd15980   88 VFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLhvqeEKNYRVVLGSQNKTspvyWCREDWP- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 258 dQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVP-GFQTEQIRKRLRCRRKTVLVLMCILTA--YVLCWAPF 334
Cdd:cd15980  167 -NQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPhTGKHNQEQRHVVSRKKQKVIKMLLIVAllFILSWLPL 245

                 ....*....
gi 528968953 335 YGFAIVRDF 343
Cdd:cd15980  246 WTLMMLSDY 254
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
97-374 4.86e-26

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 106.84  E-value: 4.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15396    3 LIIAYSVVTIVGLFG--NLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDH--WIFGETMCKLTSF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYF--TTETVLVIVKS-----QEKI 249
Cdd:cd15396   79 VQSVSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFhqLTDEPFRNLSShsdfyKDKV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGQIWP--VDQQIYYKSYFLFifgiEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAY 327
Cdd:cd15396  159 VCIEAWPseTERLIFTTSLLVF----QYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENKRINTMLISIVVTF 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 328 VLCWAPFYGFAIVRDFFPTVFVKEKHYLtAFYVVECIAMSNSMINTV 374
Cdd:cd15396  235 AACWLPLNIFNVVFDWNHEVLMSCHHNL-VFTLCHLVAMVSTCINPI 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
106-387 7.86e-26

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 106.02  E-value: 7.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISD--FLVAIvccPFEMdyYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15094   10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADecFLIGL---PFLI--VTMILKYWPFGAAMCKIYMVLTSINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPrMKYQT---ATGLIALVWVVSILVAIPSAYFTTETVLVIVKSqekifCGQIWPVDQQ 260
Cdd:cd15094   85 TSSFTLTVMSADRYLAVCHPIRS-MRYRTpfiAKVVCATTWSISFLVMLPIILYASTVPDSGRYS-----CTIVWPDSSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 IY-YKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVpGFQTEQIRKRLRCRRKTVLVLMCIlTAYVLCWAPFYGFAI 339
Cdd:cd15094  159 VNgQKAFTLYTFLLGFAIPLLLISVFYTLVILRL--RTV-GPKNKSKEKRRSHRKVTRLVLTVI-SVYIICWLPYWAFQV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 340 VRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15094  235 HLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
106-376 9.85e-26

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 105.42  E-value: 9.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd14982   10 IFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGG-WWPFGDFLCRLTGLLFYINMYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTEtvlvIVKSQEKIFCGQIWPVDQQIYY 263
Cdd:cd14982   88 ILFLTCISVDRYLAVVHPLKSRRLRRKryAVGVCAGVWILVLVASVPLLLLRST----IAKENNSTTCFEFLSEWLASAA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KsYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd14982  164 P-IVLIALVVGFLIPLLIILVCYSLIIRAL-------RRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLL 235
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528968953 344 FPTVFVKE---KHYLTAFYVV-ECIAMSNSMINTVCF 376
Cdd:cd14982  236 VRLSFIADcsaRNSLYKAYRItLCLASLNSCLDPLIY 272
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
95-376 1.19e-25

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 105.60  E-value: 1.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  95 AKIVIgmaLVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDY-YVVrqlSWEHGHVLCAS 173
Cdd:cd15384    2 LKIVV---LAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWaYTV---AWLAGNTMCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAyfttetvlVIVKSQEKIFCGQ 253
Cdd:cd15384   76 VKYLQVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQA--------VIFHVERGPFVED 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKS------YFLFIFGIEFVGPVVTMTLCYARISRELwFKAVPGFQTE--------QIRKRL--RCRRKTV 317
Cdd:cd15384  148 FHQCVTYGFYTAewqeqlYNMLSLVFMFPIPLVIMVTCYVLIFITL-SKSSRDFQGLeiytrnrgPNRQRLfhKAKVKSL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 318 LVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYvvecIAMSNSMINTVCF 376
Cdd:cd15384  227 RMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFF----FGMSNSCVNPLIY 281
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
104-334 9.06e-25

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 103.20  E-value: 9.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 104 VGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd14979    8 VAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVEL-YNFWWQYPWAFGDGGCKLYYFLFEACTY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIP-SAYFTTETVLVIVKSQEK--IFCGqiwPVD 258
Cdd:cd14979   87 ATVLTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIWLVSILCAIPiLFLMGIQYLNGPLPGPVPdsAVCT---LVV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 QQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWfKAVPGFQTEQIRKRLRC--------RRKTVLVLMCILTAYVLC 330
Cdd:cd14979  164 DRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLR-SMRNIKKGTRAQGTRNVelslsqqaRRQVVKMLGAVVIAFFVC 242

                 ....
gi 528968953 331 WAPF 334
Cdd:cd14979  243 WLPF 246
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
106-343 1.20e-24

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 102.64  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVS 185
Cdd:cd15978   10 IFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIF--GSAVCKTATYFMGISVSVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMkYQT---ATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDqqIY 262
Cdd:cd15978   88 TFNLVAISLERYSAICKPLKSRV-WQTkshALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPND--VT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRD 342
Cdd:cd15978  165 QQSWYIFLLLILFLIPGIVMMTAYGLISLELY----------RGIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRA 234

                 .
gi 528968953 343 F 343
Cdd:cd15978  235 F 235
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
101-343 1.23e-24

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 102.98  E-value: 1.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTV 180
Cdd:cd15981    5 LAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLIT--GWPFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAY---FTTETVLVIVKSQEKIF----CGQ 253
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVtltVTREEHHFMVDDYNNSYplysCWE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPvDQQIyYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVP--GFQTEQIRKRLRCRRKTVLVLMCILTA--YVL 329
Cdd:cd15981  163 AWP-DTEM-RKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPirGSQGEEEEGRRVSKRKIKVINMLIIVAlfFTL 240
                        250
                 ....*....|....
gi 528968953 330 CWAPFYGFAIVRDF 343
Cdd:cd15981  241 SWLPLWTLMLLTDY 254
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
106-335 1.72e-24

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 102.14  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15012    9 VFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIP--SWPFGEVLCRMYQFVHSLSYTAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRmKYQTATGL---IALVWVVSILVAIPS--AYFTTETVLVIVKSQEKIFCGQIWPVDQQ 260
Cdd:cd15012   87 IGILVVISVERYIAILHPLRCK-QLLTAARLrvtIVTVWLTSAVYNTPYfvFSQTVEILVTQDGQEEEICVLDREMFNSK 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 261 IYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAvpgfqteqirkRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15012  166 LYDTINFIVWYLI----PLLIMTVLYSKISIVLWKSS-----------SIEARRKVVRLLVAVVVSFALCNLPYH 225
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
104-335 1.86e-24

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 102.18  E-value: 1.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 104 VGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15928    8 SVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDL-YRLWRYRPWRFGDLLCRLMYFFSETCTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPsayfttetVLVIV-----KSQEKIFCGQIWP 256
Cdd:cd15928   86 ASILHITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGP--------ALVLVgvehiQGQQTPRGFECTV 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGfQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15928  158 VNVSSGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRS-RTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFH 235
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
97-344 4.71e-24

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 100.42  E-value: 4.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCasvny 176
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGY--WPFGEILC----- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 lrtvSLYVSTNALL---------AIAIDRYLAIVHPLRPRMKYQTA--TGLIALVWVVSILVAIPSayfttetvLVIVKs 245
Cdd:cd15329   74 ----DVWISFDVLLctasilnlcAISVDRYLVITRPLTYAVKRTPKrmALMIAIVWLLSALISIPP--------LFGWK- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 246 qEKIFCGQIWPVDQQIYYKSYFLFifgIEFVGPVVTMTLCYARIsrelwFKAVpgfqteqirKRLRCRRKTVLVLMcilT 325
Cdd:cd15329  141 -NKVNDPGVCQVSQDFGYQIYATF---GAFYIPLIVMLVLYYKI-----YRAA---------KSERKAIKTLGIIM---G 199
                        250
                 ....*....|....*....
gi 528968953 326 AYVLCWAPFYGFAIVRDFF 344
Cdd:cd15329  200 AFTLCWLPFFILALLRPFL 218
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
106-372 5.34e-24

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 101.13  E-value: 5.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15124   10 IILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADE--WLFGRVGCKLIPFIQLTSVGVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLI--ALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQIYY 263
Cdd:cd15124   88 VFTLTALSADRYKAIVRPMDIQASNALMKICLkaALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAPYPHSNELHP 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIEFVGPVVTMTLCYARISRELWFKA--VPGFQTEQIRKRLRCRR---KTVLVLMCIltaYVLCWAPFYGFA 338
Cdd:cd15124  168 KIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAynLPVEGNVHVRRQIESRKrlaKTVLVFVGL---FAFCWLPNHIIY 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 528968953 339 IVRDF-FPTVFVKEKHYLTAFyVVECIAMSNSMIN 372
Cdd:cd15124  245 LYRSYhYSEVDTSMLHFVSSI-CARILAFTNSCVN 278
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-372 7.66e-24

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 100.41  E-value: 7.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYL 177
Cdd:cd15125    2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEE--WMFGTVGCKLIPVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPlrprMKYQTATGLI------ALVWVVSILVAIPSAYFTteTVLVIVKSQEKIFC 251
Cdd:cd15125   80 QLTSVGVSVFTLTALSADRYKAIVNP----MDIQTSSAVLrtclkaIAIWVVSVLLAVPEAVFS--EVAHIMPDDNTTFT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQI-WPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKA--VPGFQTEQIRKRLRCRRKTVLVLMCILTAYV 328
Cdd:cd15125  154 ACIpYPQTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAhnIPGEYSEHSKRQMETRKRLAKIVLVFVGLFA 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 329 LCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15125  234 FCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLVARVLSFCNSCVN 277
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
112-376 7.97e-24

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 100.58  E-value: 7.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15197   16 VGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVE--WRAGDFACKVIRYLQVVVTYASTYVLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLvivkSQEKIFCGQIWPVDqqIYYKSYFLFIF 271
Cdd:cd15197   94 LSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLIIFEKTGL----SNGEVQCWILWPEP--WYWKVYMTIVA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 272 GIEFVGPVVTMTLCYARISRELWFK-----AVPGFQTEQIRKRL--------RCRRKTVLVLMCILTAYVLCWAPFYGFA 338
Cdd:cd15197  168 FLVFFIPATIISICYIIIVRTIWKKskiqvTINKAGLHDGSSRRsssrgiipRAKIKTIKMTFVIVTVFIICWSPYFVFD 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 528968953 339 IVRDFfpTVFVKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15197  248 LLDVF--GLLPRSKTKIAAATFIQSLAPLNSAINPLIY 283
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
106-334 1.23e-23

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 99.23  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpfemdYYVVRQLSWEHGH------VLCASVNYLRT 179
Cdd:cd15196   10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAL--------FNVLPQLIWDITYrfyggdLLCRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAY-FTTETVLVIVksqekifcGQIWPV 257
Cdd:cd15196   82 VGMYASSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFiFSYQEVGSGV--------YDCWAT 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 258 DQQIY-YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirkrlRCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15196  154 FEPPWgLRAYITWFTVAVFVVPLIILAFCYGRICYVVW----------------RAKIKTVKLTLVVVACYIVCWTPF 215
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
106-334 1.32e-23

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 99.67  E-value: 1.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEM-DYYVVRqlSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd14997   10 IFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALvETWARE--PWLLGEFMCKLVPFVELTVAHA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCgqIWPVDQQiY 262
Cdd:cd14997   88 SVLTILAISFERYYAICHPLQAKyvCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVC--RTPADTF-W 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISREL-WFKAVP-GFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd14997  165 KVAYILSTIVVFFVVPLAILSGLYSVICRRLvGHPALEsRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPF 238
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
108-387 2.19e-23

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 98.76  E-value: 2.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIG---NFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdyYVVRQLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15971    9 VVCIIGlcgNTLVIYVILRYAKMKTVTNIYILNLAIADELF-MLGLPFLA--IQVALVHWPFGKAICRVVMTVDGINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd15971   86 SIFCLTVMSIDRYLAVVHPIKSAkwRKPRTAKMINMAVWGVSLLVILPIMIYAG-----VQTKHGRSSCTIIWPGESSAW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARIsrelwfkaVPGFQTEQIR----KRLRCRRKTVLVLMCILTAYVLCWAPFYGF- 337
Cdd:cd15971  161 YTGFIIYTFILGFFVPLTIICLCYLFI--------IIKVKSSGIRvgssKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFn 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528968953 338 --AIVRDFFPTVFVKekhylTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15971  233 vsSVSVSISPTPGLK-----GMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
93-382 2.22e-23

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 98.11  E-value: 2.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  93 FAAKIVIGMALVGImlvcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCA 172
Cdd:cd15210    2 FAAVWGIVFMVVGV-----PGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFL--HQAWIHGETLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 173 SVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTA--TGLIALVWVVSILVAIPsayftteTVLVIVKS---QE 247
Cdd:cd15210   75 VFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRglALMIAGTWIFSFGSFLP-------LWLGIWGRfglDP 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 248 KIFCGQIWPVDQQIYYKsYFLFIFGieFVGPVVTMTLCYARisrelwfkavpgfqteqirkrlRCRRKTVLVLMCILTAY 327
Cdd:cd15210  148 KVCSCSILRDKKGRSPK-TFLFVFG--FVLPCLVIIICYAR----------------------REDRRLTRMMLVIFLCF 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 328 VLCWAPFYgfaIVRDFFPTVFVKEKHYLTAfyvveCIAMSNSMINTVCFVTVKNN 382
Cdd:cd15210  203 LVCYLPIT---LVNVFDDEVAPPVLHIIAY-----VLIWLSSCINPIIYVAMNRQ 249
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
105-335 3.27e-23

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 98.94  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15134    8 GIIFVTGVvGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFEL-YTIWQQYPWVFGEVFCKLRAFLSEMSSY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSA-YFTTETVLVIVKSQEKI----FCGQIWP 256
Cdd:cd15134   87 ASVLTITAFSVERYLAICHPLRShtMSKLSRAIRIIIAIWIIAFVCALPFAiQTRIVYLEYPPTSGEALeesaFCAMLNE 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFgieFVGPVVTMTLCYARISRELW---FKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15134  167 IPPITPVFQLSTFLF---FIIPMIAIIVLYVLIGLQLRrstLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFICWAP 243

                 ..
gi 528968953 334 FY 335
Cdd:cd15134  244 FH 245
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
97-345 3.69e-23

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 98.00  E-value: 3.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15973    1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELF-MLSVPFLAASAALQH--WPFGSAMCRTVLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR-PRMKYQTATGLIAL-VWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQI 254
Cdd:cd15973   78 VDGINMFTSVFCLTVLSVDRYIAVVHPLRaARYRRPTVAKMINIcVWILSLLVISPIIIFAD----TATRKGQAVACNLI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRcRRKTVLVLMcILTAYVLCWAPF 334
Cdd:cd15973  154 WP--HPAWSAAFVIYTFLLGFLLPVLAIGLCYILIIGKM--RAVALKAGWQQRRKSE-KKITRMVLM-VVTVFVICWMPF 227
                        250
                 ....*....|.
gi 528968953 335 YGFAIVRDFFP 345
Cdd:cd15973  228 YVVQLLNLFLP 238
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
106-377 3.73e-23

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 98.62  E-value: 3.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPfeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15195   10 LFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP--MDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIP-SAYFTTETVL--VIVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd15195   88 SFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPqSFIFSVLRKMpeQPGFHQCVDFGSAPTKKQERLY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YksyfLFIFGIEFVGPVVTMTLCYARISREL-----WFKAVPGFQTEQIRKRL--RCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15195  168 Y----FFTMILSFVIPLIITVTCYLLILFEIskmakRARDTPISNRRRSRTNSleRARMRTLRMTALIVLTFIVCWGPYY 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528968953 336 GFAIVRDFFPTVFVK-EKHYLTAFYVVECiamSNSMINTVCFV 377
Cdd:cd15195  244 VLGLWYWFDKESIKNlPPALSHIMFLLGY---LNPCLHPIIYG 283
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
96-335 6.46e-23

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 97.95  E-value: 6.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  96 KIVIGMaLVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpfemdYYVVRQLSWEHGH------V 169
Cdd:cd15386    1 KVEIGV-LAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVAL--------FQVLPQLIWEITYrfqgpdL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 170 LCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEK 248
Cdd:cd15386   72 LCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTlQQPSRQAYLMIGATWLLSCILSLPQVFIFS---LREVDQGSG 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IF-CGQIWPVDQQIyyKSYFLFIFGIEFVGPVVTMTLCYARISREL-----------------WFKAVPGFQTEQIRKRL 310
Cdd:cd15386  149 VLdCWADFGFPWGA--KAYITWTTLSIFVLPVAILIVCYSLICYEIcknlkgktqtsrsegggWRTQGMPSRVSSVRTIS 226
                        250       260
                 ....*....|....*....|....*
gi 528968953 311 RCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15386  227 RAKIRTVKMTFVIVLAYIACWAPFF 251
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
98-387 1.40e-22

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 96.60  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GN--FIFIAalaRYKKLRNLTNLLIANLAISDFLvAIVCCPFeMDYYVVRQLSWEHGHVLCASV 174
Cdd:cd14974    1 IVSLVLYALIFLLGLpGNglVIWVA---GFKMKRTVNTVWFLNLALADFL-FCLFLPF-LIVYIAMGHHWPFGSVLCKLN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPL------RPRMkyqtATGLIALVWVVSILVAIPSAYFtTETVLVIVKSQEK 248
Cdd:cd14974   76 SFVISLNMFASVFLLTAISLDRCLLVLHPVwaqnhrTVRL----ASVVCVGIWILALVLSVPYFVF-RDTVTHHNGRSCN 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IFCGQIWPVDQQIyYKSYFLFIFGIEFVGPVVTMTLCYARIsrelWFKAVpgfqteqiRKRLRCRRKTVLVLMCILTAYV 328
Cdd:cd14974  151 LTCVEDYDLRRSR-HKALTVIRFLCGFLLPLLIIAICYSVI----AVKLR--------RKRLAKSSKPLRVLLAVVVAFF 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 329 LCWAPFYGFAIVRdfFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd14974  218 LCWLPYHVFALLE--LVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
98-335 2.01e-22

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 96.38  E-value: 2.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVC-GIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpfemdYYVVRQLSWE-----HG-HVL 170
Cdd:cd15388    1 QVEIAVLAIIFACaLLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAF--------FQVLPQLVWDitdrfRGpDVL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 171 CASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSayfttetvlVIVKSQEKI 249
Cdd:cd15388   73 CRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTfQKGRARWNGPVCVAWAISLILSLPQ---------VFIFSKVEV 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCG---------QIWPVdqqiyyKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRR------ 314
Cdd:cd15388  144 APGvyecwacfiEPWGL------KAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQLLssrass 217
                        250       260       270
                 ....*....|....*....|....*....|
gi 528968953 315 ---------KTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15388  218 vaevskamiKTVKMTLVIVLVYVLCWAPFF 247
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
97-372 3.09e-22

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 95.83  E-value: 3.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFemdyYVVRQLS--WEHGHVLCAS- 173
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPF----YIPYTLTgkWPFGKVFCKAw 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 --VNYLRTVSlyvSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTteTVLVIVKSQEKI 249
Cdd:cd15048   77 lvVDYTLCTA---SALTIVLISLDRYLSVTKAVKYRAKQTKrrTVLLMALVWILAFLLYGPAIIGW--DLWTGYSIVPTG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCgqiwpvDQQIYYKSYFLFIFGI-EFVGPVVTMTLCYARISREL--WFKAVPGFQTEQI--------------RKRLRC 312
Cdd:cd15048  152 DC------EVEFFDHFYFTFITSVlEFFIPFISVSFFNLLIYLNIrkRSRRRPLRSVPILpasqnpsrarsqreQVKLRR 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 313 RRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECiamsNSMIN 372
Cdd:cd15048  226 DRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWT----NSAIN 281
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
97-343 7.34e-22

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 94.32  E-value: 7.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTG--RWILGQVLCDIWIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPsAYFTTETVLVIVKSQekifCgq 253
Cdd:cd15064   79 LDVTCCTASILHLCVIALDRYWAITDAVE-YAHKRTpkrAAVMIALVWTLSICISLP-PLFGWRTPDSEDPSE----C-- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 iwPVDQQIYYKSYFLFifgIEFVGPVVTMTLCYARIsrelwFKAVPGfqteqirkrlrcRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15064  151 --LISQDIGYTIFSTF---GAFYIPLLLMLILYWKI-----YRAAAR------------ERKAAKTLGIILGAFIVCWLP 208
                        250
                 ....*....|
gi 528968953 334 FYGFAIVRDF 343
Cdd:cd15064  209 FFLVALIVPL 218
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
106-372 8.40e-22

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 94.60  E-value: 8.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15123   10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIAD--TWLFGRIGCKLLSFIQLTSVGVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPlrprMKYQTATGLI------ALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQ 259
Cdd:cd15123   88 VFTLTVLSADRYRAIVKP----LELQTSDAVLktcckaGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPYPVSE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKA--VPGFQTEQIRKRLRCRR---KTVLVLMCIltaYVLCWAPF 334
Cdd:cd15123  164 KILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTfnMPAEEHSHARKQIESRKrvaKTVLVLVAL---FAFCWLPN 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528968953 335 YGFAIVRDF-FPTVFVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15123  241 HILYLYRSFtYHTSVDSSAFHLIATIFSRVLAFSNSCVN 279
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
106-389 8.81e-22

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 94.51  E-value: 8.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKL-RNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15097   10 IFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLE--GWVFGSFLCKAVHFFIYLTMYA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPS-AYFTTetvlviVKSQEKIFCGQIWPvDQQI 261
Cdd:cd15097   88 SSFTLAAVSVDRYLAIRYPLRSRelRTPRNAVAAIALIWGLSLLFAGPYlSYYDL------IDYANSTVCMPGWE-EARR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 262 YYKSYFLFIFGieFVGPVVTMTLCYARISRELWFKAVPgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYgfAIVR 341
Cdd:cd15097  161 KAMDTCTFAFG--YLIPVLVVSLSYTRTIKYLWTAVDP---LEAMSESKRAKRKVTKMIIIVTALFCLCWLPHH--VVIL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 342 DFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKnntiKYFKK 389
Cdd:cd15097  234 CYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVS----KHFRK 277
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
116-346 1.01e-21

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 94.36  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 116 IFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAIAID 195
Cdd:cd15383   21 VLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQ--WYAGDLACRLLMFLKLFAMYSSAFVTVVISLD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 196 RYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAY-FTTETVLVIVKSQEkifCGQIWPVDQQIYYKSYFLFIFGIE 274
Cdd:cd15383   99 RHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFlFHTVTATPPVNFTQ---CATHGSFPAHWQETLYNMFTFFCL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 275 FVGPVVTMTLCYARI----SRELWFKAVPGFQTEQIRKRL----RCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPT 346
Cdd:cd15383  176 FLLPLLIMIFCYTRIlleiSRRMKEKKDSAKNEVALRSSSdnipKARMRTLKMTIVIVSSFIVCWTPYYLLGLWYWFSPE 255
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
106-340 2.86e-21

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 93.17  E-value: 2.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGI----GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPfeMDYYVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15083    6 FILIIGLigvvGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCP--LMVISSFSGRWIFGKTGCDMYGFSGGLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAY----FTTETVLVIvksqekifCGQIW 255
Cdd:cd15083   84 GIMSINTLAAIAVDRYLVITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPPLFgwsrYVLEGLLTS--------CSFDY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 PVD---QQIYYksYFLFIFGieFVGPVVTMTLCYARI-------SRELWFKAVPGFQTEQIRKRLRCRR--KTVLVLMCI 323
Cdd:cd15083  156 LSRddaNRSYV--ICLLIFG--FVLPLLIIIYCYSFIfravrrhEKAMKEMAKRFSKSELSSPKARRQAevKTAKIALLL 231
                        250
                 ....*....|....*..
gi 528968953 324 LTAYVLCWAPfygFAIV 340
Cdd:cd15083  232 VLLFCLAWTP---YAVV 245
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
100-335 3.02e-21

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 92.41  E-value: 3.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRT 179
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAV-YVEVNGGKWYLGPILCDIYIAMDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLR----PRMKYQTATglIALVWVVSILVAIPsayfttetvlvivksqekIFCGQIW 255
Cdd:cd15053   83 MCSTASIFNLCAISIDRYIAVTQPIKyarqKNSKRVLLT--IAIVWVVSAAIACP------------------LLFGLNN 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 --PVDQQ--IYYKSYFLFIFGI-EFVGPVVTMTLCYARISRelwfkavpgfqteqirkRLRCRRKTVLVLMCILTAYVLC 330
Cdd:cd15053  143 vpYRDPEecRFYNPDFIIYSSIsSFYIPCIVMLLLYYRIFR-----------------ALRREKKATKTLAIVLGVFLFC 205

                 ....*
gi 528968953 331 WAPFY 335
Cdd:cd15053  206 WLPFF 210
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
107-387 3.71e-21

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 92.56  E-value: 3.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 107 MLVCGIG---NFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15974    8 LLVCAIGlsgNTLVIYVVLRYAKMKTVTNIYILNLAVADELF-MLGLPFLATQNAISY--WPFGSFLCRLVMTVDGVNQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPL------RPRMkyqtATGLIALVWVVSILVAIPsayfttetVLVIVKSQEKI-FCGQIWP 256
Cdd:cd15974   85 TSIFCLTVMSIDRYLAVVHPIkstkwrRPRV----AKLINATVWTLSFLVVLP--------VIIFSDVQPDLnTCNISWP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTeqirKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15974  153 EPVSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGST----KRRKSERKVTRMVVIIVVVFVFCWLPFYM 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528968953 337 FAIVRdffPTVFVKEKHYLTAFY-VVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15974  229 LNIVN---LIVILPEEPAFVGVYfFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
97-372 3.71e-21

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 92.62  E-value: 3.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNY 176
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSI--ETCWYFGDTFCKLHSS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIpsayfttetVLVIVKSQEKIFCGQI 254
Cdd:cd15055   79 LDYILTSASIFNLVLIAIDRYVAVCDPLLypTKITIRRVKICICLCWFVSALYSS---------VLLYDNLNQPGLIRYN 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQ--QIYYKSYFLFIFGIEFVGPVVTMTLCYARI-------SRELwfKAVPGFQTEQIRKRLRCR---RKTVLVLMC 322
Cdd:cd15055  150 SCYGEcvVVVNFIWGVVDLVLTFILPCTVMIVLYMRIfvvarsqARAI--RSHTAQVSLEGSSKKVSKkseRKAAKTLGI 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 323 ILTAYVLCWAPFYGFAIVRDFFPTVFvkekhylTAFYVVECIAMSNSMIN 372
Cdd:cd15055  228 VVGVFLLCWLPYYIVSLVDPYISTPS-------SVFDVLIWLGYFNSCLN 270
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
102-386 3.87e-21

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 92.50  E-value: 3.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 180
Cdd:cd14999    4 TVLSLMCVVGVaGNVYTLVVMCLSMRPRASMYVYILNLALAD-LLYLLTIPFYVSTYFLKK--WYFGDVGCRLLFSLDFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIA-LVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWpvdQ 259
Cdd:cd14999   81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAgVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTW---S 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYGFAI 339
Cdd:cd14999  158 EESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLP---KQKVLKMIFTIVLVFWACFLPFWIWQL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 340 VRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKY 386
Cdd:cd14999  235 LYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEY 281
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
92-385 5.02e-21

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 92.14  E-value: 5.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  92 FFAAKIVIGMALVGIMlvcgiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLC 171
Cdd:cd15398    1 YFLIGLYTFISLLGFL-----GNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQ--WIFGEVMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 172 ASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQE---- 247
Cdd:cd15398   74 HIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLEslkn 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 248 KIFCGQIWPVDQqiYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLmciltAY 327
Cdd:cd15398  154 KYLCIESWPSDS--YRIAFTISLLFVQYILPLVCLTVSHTSVCRSV------------KRSRSVFYRLTIVIL-----AF 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 328 VLCWAPFYGFAIVRDFFPTVfVKEKHYLTAFYVVECIAMSNSMINTVCFVTVkNNTIK 385
Cdd:cd15398  215 AVSWMPLHLFHLVTDFNANL-ISNRHFKLVYCICHLLGMLSCCLNPILYGFL-NNGIK 270
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
108-378 5.26e-21

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 92.06  E-value: 5.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIG---NFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15160    9 FVFVVGlpaNCLALWVLYLQIKKENVLGVYLLNLSLSD-LLYILTLPLWIDYTA-NHHNWTFGPLSCKVVGFFFYTNIYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWvvsILVAIPSAYFtTETVLVIVKSQEKIFCGQIWPVDQqiY 262
Cdd:cd15160   87 SIGFLCCIAVDRYLAVVHPLRFRglRTRRFALKVSASIW---VLELGTHSVF-LGHDELFRDEPNHTLCYEKYPMEG--W 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQirkrlrcRRKTVLVLMCILTAYVLCWAPFYGFAIVR- 341
Cdd:cd15160  161 QASYNYARFLVGFLIPLSLILFFYRRVLRAV--RQSPSLEREE-------KRKIIGLLLSIVVIFLLCFLPYHVVLLVRs 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528968953 342 ---DFFPTVFVKEKHYLTAFYVVECIAMSNSMINTV--CFVT 378
Cdd:cd15160  232 vieLVQNGLCGFEKRVFTAYQISLCLTSLNCVADPIlyIFVT 273
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
112-387 1.04e-20

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 91.47  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15183   16 VGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKL--KDDWIFGDAMCKFLSGFYYLGLYSEIFFIIL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPRMKYQTATGLIA--LVWVVSILVAIPSAYFTtetvlvivKSQEKI---FCGQIWPVDQQIYYKSY 266
Cdd:cd15183   93 LTIDRYLAIVHAVFALRARTVTFGIITsiITWALAILASMPCLYFF--------KSQWEFthhTCSAHFPRKSLIRWKRF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 267 ---FLFIFGIefVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd15183  165 qalKLNLLGL--ILPLLVMIICYTGIINIL------------LRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAF 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 344 FPTVFVKE----KHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15183  231 QDVLFTPSceqsQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
112-387 2.05e-20

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 90.66  E-value: 2.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYyvVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15185   16 LGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHY--VRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIIL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVH---PLRPR-MKYQTATGLIalVWVVSILVAIPSAYFTTETvlvivKSQEKIFCGQIWPVDQQIYYKSYF 267
Cdd:cd15185   93 LTIDRYLAIVHavfALRARtVTFGIITSII--TWGLAVLAALPEFIFYETQ-----ELFEEFLCSPLYPEDTEDSWKRFH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 268 ---LFIFGIEFvgPVVTMTLCYARIsrelwfkavpgfqteqIRKRLRC----RRKTVLVLMCILTAYVLCWAPfYGFAIV 340
Cdd:cd15185  166 alrMNIFGLAL--PLLIMVICYTGI----------------IKTLLRCpskkKYKAIRLIFVIMVVFFIFWTP-YNLVLL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528968953 341 RDFFPTVFV-----KEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15185  227 LSAFQSIFFetdceRSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
98-376 3.15e-20

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 89.65  E-value: 3.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15330    1 IITSLFLGTLILCAIfGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSayfttetvLVIVKSQEKIFCGQI 254
Cdd:cd15330   79 LDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRtpRRAAVLISLTWLIGFSISIPP--------MLGWRTPEDRSDPDA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFifgIEFVGPVVTMTLCYARIsrelwFKAVPGfqteqirkrlrcRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15330  151 CTISKDPGYTIYSTF---GAFYIPLILMLVLYGRI-----FKAAAR------------ERKTVKTLGIIMGTFILCWLPF 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 335 YGFAIVrdfFPtvFVKEKHYLTA--FYVVECIAMSNSMINTVCF 376
Cdd:cd15330  211 FIVALV---LP--FCESTCHMPEllGAIINWLGYSNSLLNPIIY 249
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
106-344 4.77e-20

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 89.43  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFemdYYVVRQLS--WEHGHVLCASVNYLRTVSLY 183
Cdd:cd15193   10 IFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVAD-LVFVLTLPF---WAASTALGgqWLFGEGLCKLSSFIIAVNRC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIV-----HPLRPRmkyQTATGLIALVWVVSILVAIPSAYFTtetvlvivKSQEKIFCgqiWPVD 258
Cdd:cd15193   86 SSILFLTGMSVDRYLAVVklldsRPLRTR---RCALITCCIIWAVSLVLGIPSLVYR--------NLINESVC---VEDS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 QQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFkavpgfQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFA 338
Cdd:cd15193  152 SSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRR------HFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLK 225

                 ....*.
gi 528968953 339 IVRDFF 344
Cdd:cd15193  226 AVRLLL 231
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
98-374 5.34e-20

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 88.95  E-value: 5.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYL 177
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSI-LHEMTGGYWLFGRDWCDVWHSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPsAYFTTETVLVIVKSQEKifCgqIW 255
Cdd:cd15067   80 DVLASTASILNLCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFP-AIAWWRAVDPGPSPPNQ--C--LF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 PVDQqiyykSYFLFIFGIEFVGPVVTMTLCYARISRelwfkavpgfqteqIRKRLRCRRKTVLVLMcilTAYVLCWAPFY 335
Cdd:cd15067  155 TDDS-----GYLIFSSCVSFYIPLVVMLFTYYRIYR--------------AAAKEQKAAKTLGIVM---GVFILCWLPFF 212
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528968953 336 GFAIVRDFFPTVFVKEKHylTAFYVVECIAMSNSMINTV 374
Cdd:cd15067  213 VTNILIGFCPSNCVSNPD--ILFPLVTWLGYINSGMNPI 249
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
114-374 5.85e-20

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 89.27  E-value: 5.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAI-VCCPFEMDYYVVRQLSWEHGHVLCASVnylrTVSLYVSTNALLAI 192
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIaFVFTFLSVLLVSLTPSPATWLLRKGSL----VLSLLASAYSLLAI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIpSAYFTTETVLVIVKSqekifCGQIWPvdqqIYYKSYFLFI 270
Cdd:cd14972   92 AVDRYISIVHGLTyvNNVTNKRVKVLIALVWVWSVLLAL-LPVLGWNCVLCDQES-----CSPLGP----GLPKSYLVLI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 271 FGIEFVgPVVTMTLCYARISRELW--FKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFygFA-IVRDFFPTV 347
Cdd:cd14972  162 LVFFFI-ALVIIVFLYVRIFWCLWrhANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPL--LIlLVLDVLCPS 238
                        250       260
                 ....*....|....*....|....*..
gi 528968953 348 FVKEKHYLTAFYVvecIAMSNSMINTV 374
Cdd:cd14972  239 VCDIQAVFYYFLV---LALLNSAINPI 262
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
100-372 6.01e-20

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 89.82  E-value: 6.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRT 179
Cdd:cd15058    4 LLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGK--WQLGNFWCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRprmkYQT------ATGLIALVWVVSILVA---IPSAYFTTETvlvivksQEKIF 250
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPLR----YQVlltkrrARVIVCVVWIVSALVSfvpIMNQWWRAND-------PEAND 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARI-------------SRELWFKAVPGFQTEQIRKRLRCRR--- 314
Cdd:cd15058  151 CYQDPTCCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVfliatrqlqlidkRRLRFQSECPAPQTTSPEGKRSSGRrps 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 315 --------KTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEkhyltAFYVVECIAMSNSMIN 372
Cdd:cd15058  231 rltvvkehKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGE-----VFLLLNWLGYINSGLN 291
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
107-335 6.39e-20

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 89.29  E-value: 6.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 107 MLVCGIGNFIFIAALARYKKLRNL-TNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15382   11 FLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMMPLEIGWAATVA--WLAGDFLCRLMLFFRAFGLYLS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAY-FTTETvLVIVKSQEKIFCGQIWPVDQQIyyK 264
Cdd:cd15382   89 SFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFiFHVES-HPCVTWFSQCVTFNFFPSHDHE--L 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLFIFGIEFVGPVVTMTLCYARISRELWFKA---VPGFQTEQIRKRLRC---------RRKTVLVLMCILTAYVLCWA 332
Cdd:cd15382  166 AYNIFNMITMYALPLIIIVFCYSLILCEISRKSkekKEDVSEKSSSVRLRRssvglleraRSRTLKMTIVIVLVFIICWT 245

                 ...
gi 528968953 333 PFY 335
Cdd:cd15382  246 PYF 248
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
107-377 7.88e-20

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 89.10  E-value: 7.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 107 MLVCGIG---NFIFIAALARYKKLRNL--TNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd14976    8 MVVFTVGllgNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYAL--DFVWPFGTAMCKVVRYVTKLN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSAYFTTETvlviVKSQEKIFCGQIWPVDQ 259
Cdd:cd14976   86 MYSSIFFLTALSVTRYIAVARALKHgwIRKAFGAFATTIAIWAAAALAAIPEAIFSTDT----WSSVNHTLCLLRFPKNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIE-----FVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRLRCRRKTVLVLMCILTaYVLCWAPF 334
Cdd:cd14976  162 SVTRWYNWLGMYQLQkvvlgFFLPLGIITLSYLLLLRFL--------QRKRGGSKRRKSRVTKSVFIVVLS-FFICWLPN 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 335 Y---------GFAIV--RDFFPTVFVKekhyltAFYVVECIAMSNSMINTV--CFV 377
Cdd:cd14976  233 QalslwsaliKFDDVpfSDAFFAFQTY------AFPVAICLAHSNSCLNPVlyCLV 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
102-387 9.04e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 88.85  E-value: 9.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLvAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTV 180
Cdd:cd15089    5 ALYSVVCVVGlLGNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLME--TWPFGELLCKAVLSIDYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPrMKYQT---ATGLIALVWVVSILVAIPsayfttetVLVIVKSQE----KIFCGQ 253
Cdd:cd15089   82 NMFTSIFTLTMMSVDRYIAVCHPVKA-LDFRTpakAKLINICIWVLSSGVGVP--------IMVMAVTKTprdgAVVCML 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPvDQQIYYKSYF---LFIFGieFVGPVVTMTLCYARISreLWFKAVPGFQTEQIRKRlRCRRKTVLVLMcILTAYVLC 330
Cdd:cd15089  153 QFP-SPSWYWDTVTkicVFIFA--FVVPILVITVCYGLMI--LRLRSVRLLSGSKEKDR-NLRRITRMVLV-VVAAFIIC 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 331 WAPFYGFAIVrdfFPTVFVKEKHYLTAFYVVECIAM--SNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15089  226 WTPIHIFVIV---WTLVDIDRRNPLVVAALHLCIALgyANSSLNPVLYAFLDENFKRCF 281
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
97-335 1.16e-19

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 88.70  E-value: 1.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15132    1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSD-LLILLCLPFDL-YRLWKSRPWIFGEFLCRLYHY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPsaYFTTETVLVIVKSQEKIFCGQI 254
Cdd:cd15132   79 ISEGCTYATILHITALSIERYLAICFPLRAKVlvTRRRVKCVIAALWAFALLSAGP--FLFLVGVEQDNNIHPDDFSREC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYK--SYFLFIFGIEFVGPVVTMTLCYARISRELWfKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWA 332
Cdd:cd15132  157 KHTPYAVSSGllGIMIWVTTTYFFLPMLCLSFLYGFIGRKLW-KSKNDLRGPNAAARERSHRQTVRILAVVVLAFIICWL 235

                 ...
gi 528968953 333 PFY 335
Cdd:cd15132  236 PFH 238
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
97-343 1.21e-19

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 88.54  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGE--WPLGPVFCNIYIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKifcgqi 254
Cdd:cd15051   79 LDVMLCTASILNLFAISLDRYLAITAPLRypSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGDT------ 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wPVDQQIYYKSYFLFIFGI-EFVGPVVTMTLCYARISRelwfkaVPGFQTEQIRKRLRCR-------------RKTVLVL 320
Cdd:cd15051  153 -PNQCRFELNPPYVLLVAIgTFYLPLLIMCGVYLRIFR------IAREQAKRINALTPAStanssksaatareHKATVTL 225
                        250       260
                 ....*....|....*....|...
gi 528968953 321 MCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd15051  226 AAVLGAFIICWFPYFTYFTYRGL 248
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
101-340 1.25e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 88.53  E-value: 1.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCpFEMDYYVVRQLSWEHGHVLCASVNYLRTV 180
Cdd:cd15337    7 IAIVGILGVIG--NLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNG-FPLKTISSFNKKWIWGKVACELYGFAGGI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIP----------SAYFTTETVLVIVKSQEK 248
Cdd:cd15337   84 FGFMSITTLAAISIDRYLVIAKPLEamKKMTFKRAFIMIIIIWLWSLLWSIPpffgwgryvpEGFQTSCTFDYLSRDLNN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IfcgqiwpvdqqIYykSYFLFIFGieFVGPVVTMTLCYARI-------SRELW--FKAVPGFQTEQIRKRLRCRRKTVLV 319
Cdd:cd15337  164 R-----------LF--ILGLFIFG--FLCPLLIIIFCYVNIiravrnhEKEMTqtAKSGMGKDTEKNDARKKAEIRIAKV 228
                        250       260
                 ....*....|....*....|.
gi 528968953 320 LMCILTAYVLCWAPfygFAIV 340
Cdd:cd15337  229 AIILISLFLLSWTP---YAVV 246
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
106-372 1.35e-19

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 88.08  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEmdyyVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd14968   10 IAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLA----ILISLGLPTNFHGCLFMACLVLVLTQSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAI-PSAYFTTETVLVIVKSQEKIFCGQIWPVDqqIY 262
Cdd:cd14968   86 IFSLLAIAIDRYLAIKIPLRYKslVTGRRAWGAIAVCWVLSFLVGLtPMFGWNNGAPLESGCGEGGIQCLFEEVIP--MD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYFLFiFGIEFVgPVVTMTLCYARI----SRELwFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFA 338
Cdd:cd14968  164 YMVYFNF-FACVLV-PLLIMLVIYLRIfrviRKQL-RQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCWLPLHIIN 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528968953 339 IVRDFFPTVFVKEkhylTAFYVveCIAMS--NSMIN 372
Cdd:cd14968  241 CITLFCPECKVPK----ILTYI--AILLShaNSAVN 270
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
105-335 1.44e-19

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 88.14  E-value: 1.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15168    8 GVVFLVGLlLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSL-PFLIYYYANGD-HWIFGDFMCKLVRFLFYFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTETVLVivksqEKIFCGQIWPVDQQI 261
Cdd:cd15168   86 GSILFLTCISVHRYLGICHPLRSLGKLKKrhAVAISVAVWILVLLQLLPILFFATTGRKN-----NRTTCYDTTSPEELN 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 262 YYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQirkRLRCRRKTVLVlmciLTAYVLCWAPFY 335
Cdd:cd15168  161 DYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSAL---RRKSIRLVIIV----LALFAVCFLPFH 227
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
112-387 2.14e-19

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 87.50  E-value: 2.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFeMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15184   16 VGNMLVVLILINCKKLKSMTDIYLLNLAISDLLF-LLTLPF-WAHYAANE--WVFGNAMCKLLTGLYHIGFFSGIFFIIL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPrMKYQTAT-GLI--ALVWVVSILVAIPSAYFTtetvlvivKSQEKIF---CGQIWPVDQQIYYKS 265
Cdd:cd15184   92 LTIDRYLAIVHAVFA-LKARTVTfGVVtsVVTWVVAVFASLPGIIFT--------KSQKEGShytCSPHFPPSQYQFWKN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 266 YF-LFIFGIEFVGPVVTMTLCYARISRELwfkavpgfqteqirkrLRCRR-----KTVLVLMCILTAYVLCWAPfYGFAI 339
Cdd:cd15184  163 FQtLKMNILGLVLPLLVMIICYSGILKTL----------------LRCRNekkrhKAVRLIFTIMIVYFLFWAP-YNIVL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528968953 340 VRDFFPTVFVKEKHYLT-----AFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15184  226 LLNTFQEFFGLNNCSSSnrldqAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
97-375 3.83e-19

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 86.63  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMG--YWYFGSVWCEIWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPL-------RPRMKYqtatgLIALVWVVSILVAIPSAYFTTEtvlvivKSQEKI 249
Cdd:cd15059   79 LDVLFCTASIVNLCAISLDRYWSVTQAVeynlkrtPRRAKA-----MIAAVWIISAVISLPPLFGWKD------EQPWHG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGQIwPVDQQIYyksYFLFIFGIEFVGPVVTMTLCYARISRElwfkavpgfqteqirKRLRCRRKTvLVLMCILTAYVL 329
Cdd:cd15059  148 AEPQC-ELSDDPG---YVLFSSIGSFYIPLLIMIIVYARIYRA---------------AKRKERRFT-LVLGVVMGAFVL 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVC 375
Cdd:cd15059  208 CWLPFFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIF 253
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
106-334 4.11e-19

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 86.86  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrqLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15079   10 LGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFY---EGWALGPLGCQIYAFLGSLSGIGS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPL-RPRMKYQTATGLIALVWVVSILVAIPSA-----YFTTETVLVIvksqekifCGQIWpVDQ 259
Cdd:cd15079   87 IWTNAAIAYDRYNVIVKPLnGNPLTRGKALLLILFIWLYALPWALLPLlfgwgRYVPEGFLTS--------CSFDY-LTR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkAVPGFQTEQIRK----RLRCRR---------KTVLVLMCILTA 326
Cdd:cd15079  158 DWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVF--AHEKALREQAKKmnvvSLRSNAdankqsaeiRIAKVALTNVFL 235

                 ....*...
gi 528968953 327 YVLCWAPF 334
Cdd:cd15079  236 WFIAWTPY 243
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
98-387 5.72e-19

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 86.55  E-value: 5.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15091    1 VIITAVYSVVFVVGlVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLMN--SWPFGDVLCKIVIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPrMKYQT---ATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEkifCGQ 253
Cdd:cd15091   78 IDYYNMFTSIFTLTMMSVDRYIAVCHPVKA-LDFRTplkAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTE---CSL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYF-LFIFGIEFVGPVVTMTLCYARISreLWFKAVPGFQTEQIRKRlRCRRKTVLVLMcILTAYVLCWA 332
Cdd:cd15091  154 QFPDDDYSWWDTFMkICVFIFAFVIPVLIIIVCYTLMI--LRLKSVRLLSGSREKDR-NLRRITRLVLV-VVAVFVVCWT 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 333 PFYGFAIVRDFFPTvfVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15091  230 PIHIFILVEALGSV--SHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
71-398 5.96e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.14  E-value: 5.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  71 FSYGDYDMPLDED-EDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALARYKkLRNLTNLLIANLAISDfLVAIVC 149
Cdd:PHA03087  14 TTDYYYDTYYDEDyADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSD-LLFVMT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 150 CPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILV 227
Cdd:PHA03087  92 LPFQIYYYILFQWSF--GEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKsnKINTVKYGYIVSLVIWIISIIE 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 228 AIPSAYFTTetvlviVKSQEKIFCGQIWPVDQQIYYKSYFLF---IFGieFVGPVVTMTLCYARISRELwfkavpgfQTE 304
Cdd:PHA03087 170 TTPILFVYT------TKKDHETLICCMFYNNKTMNWKLFINFeinIIG--MLIPLTILLYCYSKILITL--------KGI 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 305 QIRKRlrcRRKTVLVLMCILTAYVLCWAPFYgfaivrdffPTVFVKEKHYLT-------------AFYVVECIAMSNSMI 371
Cdd:PHA03087 234 NKSKK---NKKAIKLVLIIVILFVIFWLPFN---------VSVFVYSLHILHfksgckavkyiqyALHVTEIISLSHCCI 301
                        330       340
                 ....*....|....*....|....*..
gi 528968953 372 NTVCFVTVKNNTIKYFKKIMLLHWKAS 398
Cdd:PHA03087 302 NPLIYAFVSEFFNKHKKKSLKLMFTSS 328
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
100-335 1.41e-18

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 85.12  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLrt 179
Cdd:cd15066    3 GFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGR--WMFGYFMCDVWNSL-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 vSLYVSTNALL---AIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVA---IPSAYFTTETVLVIVKSQEKIfC 251
Cdd:cd15066   79 -DVYFSTASILhlcCISVDRYYAIVQPLeyPSKMTKRRVAIMLANVWISPALISflpIFLGWYTTEEHLQYRKTHPDQ-C 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 gqiwpvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRElwfkavpgfqteqiRKRlrcRRKTVLVLMCILTAYVLCW 331
Cdd:cd15066  157 -------EFVVNKIYALISSSVSFWIPCIVMIFTYYRIYLE--------------AKR---EHKAAKTLGIIMGAFILCW 212

                 ....
gi 528968953 332 APFY 335
Cdd:cd15066  213 LPFF 216
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
98-387 2.35e-18

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 84.66  E-value: 2.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLvAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15090    1 ITIMALYSIVCVVGLfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG--TWPFGNILCKIVIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPrMKYQT---ATGLIALVWVVSILVAIPSAYFTTETvlvivKSQEKIFCGQ 253
Cdd:cd15090   78 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKA-LDFRTprnAKIVNVCNWILSSAIGLPVMFMATTK-----YRQGSIDCTL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRlRCRRKTVLVLMcILTAYVLCWAP 333
Cdd:cd15090  152 TFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL--KSVRMLSGSKEKDR-NLRRITRMVLV-VVAVFIVCWTP 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 334 FYGFAIVRDFfptVFVKEKHYLTAFYVVeCIAM--SNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15090  228 IHIYVIIKAL---VTIPETTFQTVSWHF-CIALgyTNSCLNPVLYAFLDENFKRCF 279
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
99-335 2.40e-18

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 84.48  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGI-GN-FIFIAALARYKKlRNLTNLLIANLAISDfLVAIVCCPFEMDYyvVRQLSWEHGHVLCASVNY 176
Cdd:cd15121    2 LGIAILSLAFILGFpGNlFVVWSVLCRMKK-RSVTCILVLNLALAD-AAVLLTAPFFLHF--LSGGGWEFGSVVCKLCHY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHP-LRPRMKYQTAT-GLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQI 254
Cdd:cd15121   78 VCGVSMYASIFLITLMSMDRCLAVAKPfLSQKMRTKRSVrALLLAIWIVAFLLSLPMPFYRT----VLKKNINMKLCIPY 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYARISRELwfkavpgfqteQIRKRLRCRRKTVLVLMcILTAYVLCWAPF 334
Cdd:cd15121  154 HPSVGHEAFQYLFETITG--FLLPFTAIVTCYSTIGRRL-----------RSARFRRKRRTNRLVVL-IIATFALFWLPY 219

                 .
gi 528968953 335 Y 335
Cdd:cd15121  220 H 220
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
98-343 2.61e-18

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 84.36  E-value: 2.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCC-PFEMDYYVVRQlSWEHGHVLCASVN 175
Cdd:cd14995    1 VVATFLVLLICGVGIvGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGlPNEIESLLGPD-SWIYGYAGCLLIT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPlrprMKYQT------ATGLIALVWVVSILVAIPsAYFTTETVLVIVKSQEKI 249
Cdd:cd14995   80 YLQYLGINASSLSITAFTIERYIAICHP----MKAQFictvsrAKKIICFVWIFTSLYCSP-WLFLLDLSIKHYGDDIVV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGqiWPVDQQiYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqirkrlRCRRKTVLVLMCILTAYVL 329
Cdd:cd14995  155 RCG--YKVSRH-YYLPIYLADFVLFYVIPLLLAIVLYGLIGRILF----------------SSRKQVTKMLAVVVVLFAL 215
                        250
                 ....*....|....
gi 528968953 330 CWAPFYGFAIVRDF 343
Cdd:cd14995  216 LWMPYRTLVVYNSF 229
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
97-374 2.93e-18

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 84.79  E-value: 2.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLR-NLTNLLIANLAISDFLVAIVCCPFE-----MDYYVVRQL--SWEHGH 168
Cdd:cd15057    1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAavnevAGYWPFGSFcdVWVSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 169 VLCASVNYLRtvslyvstnaLLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVA-IP---SAYFTTETVLVI 242
Cdd:cd15057   81 IMCSTASILN----------LCVISVDRYWAISSPFRyeRRMTRRRAFIMIAVAWTLSALISfIPvqlGWHRADDTSEAL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 243 VKSQEKIFCGQIWpvdQQIYYKSYFLfifgIEFVGPVVTMTLCYARISRelwfkaVPGFQTEQI---------------- 306
Cdd:cd15057  151 ALYADPCQCDSSL---NRTYAISSSL----ISFYIPVAIMIVTYTRIYR------IARRQIRRIaaleraaqestnpdss 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 307 -RKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHY-LTAFYVVECIAMSNSMINTV 374
Cdd:cd15057  218 lRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCDLRTAQFPCVpDTTFIVFVWLGWANSSLNPI 287
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
97-372 3.00e-18

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 83.95  E-value: 3.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFemdyYVVRQL--SWEHGHVLC--- 171
Cdd:cd15061    2 LISFLILAIIFTI--FGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPL----AIIRQLlgYWPLGSHLCdfw 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 172 ASVNYLRTVSlyvSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSayfttetvlvIVKSQEKI 249
Cdd:cd15061   76 ISLDVLLCTA---SILNLCCISLDRYFAITYPLkyRTKRSRRLAITMILAVWVISLLITSPP----------LVGPSWHG 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FCGqiwpvDQQIYY---KSYFLFIFGIEFVGPVVTMTLCYARISRelwfkavpgfqteqIRKRlrcRRKTVLVLMCILTA 326
Cdd:cd15061  143 RRG-----LGSCYYtydKGYRIYSSMGSFFLPLLLMLFVYLRIFR--------------VIAK---ERKTAKTLAIVVGC 200
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 327 YVLCWAPFYGFAIVRDFFPTVFvkekhYLTAFYVVECIAMSNSMIN 372
Cdd:cd15061  201 FIVCWLPFFIMYLIEPFCDCQF-----SEALSTAFTWLGYFNSVIN 241
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
112-388 3.35e-18

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 84.47  E-value: 3.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYyVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15380   16 LGNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFWAEN-IRNQFNWPFGNFLCRVISGVIKANLFISIFLVVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSayFTTETVLViVKSQEKIFCGQIWPVDQQIYYKSYFLF 269
Cdd:cd15380   94 ISQDRYRTLVHTMTSRRqrSRRQAQVICLLIWVFGGLLSIPT--FLFRSVKH-VPDLNISACILLFPHEAWHFARRVELN 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 270 IFGieFVGPVVTMTLCYARISRELwfkavpGFQTEQIRKRLRCRR--KTVLVLMCILTAYVLCWAPFYGFA--------- 338
Cdd:cd15380  171 IVG--FLLPLAAIVFFNFHIIASL------RERTEESRKRCGGLKdtKATRLILTLVLMFLVCWTPYHFFAfldflfqve 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 339 IVRDFFPTVFVKEKHYLTAFYvveciAMSNSMINTVCFVTVKnntiKYFK 388
Cdd:cd15380  243 VIQGCFWEEFIDLGLQLANFF-----AFANSCLNPVIYVFAG----KLFR 283
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
97-376 5.31e-18

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 83.70  E-value: 5.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFemdYYVVRQLS-WEHGHVLCASVN 175
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELF-MLGLPF---LAAQNALSyWPFGSFMCRLVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKifCGQ 253
Cdd:cd15972   77 TVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSkwRKPPVAKTVNATVWALSFLVVLPVVIFSG-----VPGGMGT--CHI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQirKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15972  150 AWPEPAQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATST--KRRGSERKVTRMVVIVVAAFVLCWLP 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528968953 334 FYGFAIVRDFFPtvFVKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15972  228 FYALNIVNLVCP--LPEEPSLFGLYFFVVVLSYANSCANPIIY 268
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
97-356 6.42e-18

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 82.86  E-value: 6.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15050    1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESK--WILGRPVCLFWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSA---YFTTETVLVIVKSQekif 250
Cdd:cd15050   79 MDYVASTASIFSLFILCIDRYRSVQQPLK-YLKYRTktrASLMISGAWLLSFLWVIPILgwhHFARGGERVVLEDK---- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 cgqiwpVDQQIYYKSYFLFIFGI-EFVGPVVTMTLCYARIsrelwFKAVpgfqteqirkrlRCRRKTVLVLMCILTAYVL 329
Cdd:cd15050  154 ------CETDFHDVTWFKVLTAIlNFYIPSLLMLWFYAKI-----FKAV------------NRERKAAKQLGFIMAAFIL 210
                        250       260
                 ....*....|....*....|....*..
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKEKHYLT 356
Cdd:cd15050  211 CWIPYFILFMVIAFCKNCCNENLHMFT 237
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
98-340 9.73e-18

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 82.92  E-value: 9.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdyYVVRQLSWEHGHVLCASVNY 176
Cdd:cd14975    1 VLGCTLLSLAFAIGLpGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWI--YFLATGTWDFGLAACKGCVY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPL---RPRMKyQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCGQ 253
Cdd:cd14975   78 VCAVSMYASVFLITLMSLERFLAVSRPFvsqGWRAK-ALAHKVLAIIWLLAVLLATPVIAFRH-----VEETVENGMCKY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYksYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqiRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd14975  152 RHYSDGQLVF--HLLLETVVGFAVPFTAVVLCYSCLLRRLR------------RRRFRRRRRTGRLIASVVVAFAACWLP 217

                 ....*..
gi 528968953 334 FYGFAIV 340
Cdd:cd14975  218 YHVGNLL 224
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
105-387 1.03e-17

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 82.86  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFeMDYYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15192    8 SIIFVVGIfGNSLVVIVIYCYMKLKTVANIFLLNLALAD-LCFLITLPL-WAAYTAMEYHWPFGNFLCKIASALVSFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIA--LVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQqi 261
Cdd:cd15192   86 ASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTciVIWLLAGVASLPAIIHRD---VFFIENTNITVCAFHYPSQN-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 262 yykSYFLFIFGIE-----FVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15192  161 ---STLLVGLGLMknllgFLIPFLIILTCYTLIGKAL-------KKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQI 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 337 FAIVRDFFPTVFVKEKHYL----TAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15192  231 FTFLDVLIQLKVIQDCHIAdivdTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
106-377 1.17e-17

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 82.49  E-value: 1.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVRqLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15191   10 IFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVAD-LLFLATLPLWATYYSYG-YNWLFGSVMCKICGSLLTLNLFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYF----TTETVLVIVksqekifCGQIWPVDQQ 260
Cdd:cd15191   88 IFFITCMSVDRYLAVVYPLRSqRRRSWQARLVCLLVWVLACLSSLPTFYFrdtyYIEELGVNA-------CIMAFPNEKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 IY-YKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRkrlrcRRKTVLVLMCILTAYVLCWAPFYgfai 339
Cdd:cd15191  161 AQwSAGLALMKNTLGFLIPLIVIATCYFGIGRHL--LKTKGFGKNKQR-----RDKVLKMVAAVVLAFLICWFPFH---- 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 340 VRDFFPTvfVKEKHYLTAFYVVE----------CIAMSNSMINTV--CFV 377
Cdd:cd15191  230 VLTFLDA--LARMGVINNCWVITvidkalpfaiCLGFSNSCINPFlyCFV 277
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
98-335 1.70e-17

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 82.17  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLR---NLTNLLIANLAISDFLVaIVCCPFeMDYYVVRQLSWEHGHVLCAS 173
Cdd:cd15338    1 VIMPSVFGVICFLGIiGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLF-LLGMPF-LIHQLLGNGVWHFGETMCTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIF 250
Cdd:cd15338   79 ITALDTNSQITSTYILTVMTLDRYLATVHPIR-STKIRTprvAVAVICLVWILSLLSITPVWMYAG----LMPLPDGSVG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWP-VDQQIYYksYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPgfqTEQIRKRLRCRRKTVLVLmCILTAYVL 329
Cdd:cd15338  154 CALLLPnPETDTYW--FTLYQFFLAFALPLVVICVVYFKILQNMASTVAP---LPQRSLRVRTKKVTRMAV-AICLAFFI 227

                 ....*.
gi 528968953 330 CWAPFY 335
Cdd:cd15338  228 CWAPFY 233
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
97-376 1.90e-17

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 81.60  E-value: 1.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLC---AS 173
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMG--YWPLGPLLCdlwLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYlrTVSLyVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFttetvlvivksQEKIFC 251
Cdd:cd15049   79 LDY--VASN-ASVMNLLLISFDRYFSVTRPLtyRAKRTPKRAILMIALAWVISFVLWAPAILG-----------WQYFVG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIWPVDQ-QIYYKSYFLFIFG---IEFVGPVVTMTLCYARISRElwfkavpgfqTEQIRKRLRcrrktvlVLMCILTAY 327
Cdd:cd15049  145 ERTVPDGQcYIQFLDDPAITFGtaiAAFYLPVLVMTILYWRIYRE----------TARERKAAR-------TLSAILLAF 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 328 VLCWAPFYGFAIVRDFFPTVfVKEKHYLTAFYVveCIAmsNSMINTVCF 376
Cdd:cd15049  208 IITWTPYNILVLVSTFCAKC-IPDTLWSFGYWL--CYI--NSTINPFCY 251
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
106-337 1.99e-17

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 81.83  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFlVAIVCCPFEMDYYVVRQLsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15194   10 VFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVDKEVVLGP-WRSGSFLCKGSSYIISVNMYCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRmKYQT---ATGLIALVWVVSILVAIPsayftTETVLVIVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd15194   88 VFLLTCMSLDRYLAIVLPLVSR-KFRTkhnAKVCCTCVWMLSCLLGLP-----TLLSRELKKYEEKEYCNEDAGTPSKVI 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 263 YkSYFLFIFGieFVGPVVTMTLCYARISRELWfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGF 337
Cdd:cd15194  162 F-SLVSLIVA--FFLPLLSILTCYCTIIWKLC------HHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLF 227
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
97-382 2.40e-17

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 81.50  E-value: 2.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccPFEMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15401    1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVY--PYPLILLAIFHNGWTLGNIHCQISGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQI 254
Cdd:cd15401   79 LMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYnmKKTCCYVCLTWVLTLAAIVPNFFVGS------LQYDPRIYSCTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wpvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelWFKAVpgfqteQIRKRLR--CRRK-------TVLVLMCILT 325
Cdd:cd15401  153 ----AQTVSSSYTITVVVVHFIVPLSIVTFCYLRI----WVLVI------QVKHRVRqdSKQKlkandirNFLTMFVVFV 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 326 AYVLCWAP--FYGFAI-VRDFFPTVFVKEKHYLTAFYvvecIAMSNSMINTVCFVTVKNN 382
Cdd:cd15401  219 LFAVCWGPlnFIGLAVaINPLKVAPKIPEWLFVLSYF----MAYFNSCLNAVIYGVLNQN 274
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
105-336 3.10e-17

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 81.35  E-value: 3.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFemdYYVVRQLSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15179    8 SIIFLLGIvGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTL-PF---WAVDAAANWYFGNFLCKAVHVIYTVNLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPL---RPRMKYQTATGLIAlVWVVSILVAIPSAYFTTETVLvivksQEKIFCGQIWPVDQQ 260
Cdd:cd15179   84 SSVLILAFISLDRYLAIVHATnsqRPRKLLAEKVVYVG-VWLPALLLTVPDLVFAKVSEL-----DDRYICDRIYPEDTF 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 261 IYYKSYFLFI-FGIEFVGPVVTMTLCYARISRELwfKAVPGFQteqirkrlrcRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15179  158 ELWVVAFRFQhILVGLVLPGLVILTCYCIIISKL--SHSKGHQ----------KRKALKTTVILILAFFACWLPYYI 222
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
113-342 3.20e-17

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 81.32  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEM--DYYVVRQLswehGHVLCASVNYLRTVSLYVSTNALL 190
Cdd:cd15000   16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLvhDFFQNYVL----GSVGCKLEGFLEGSLLLASVLALC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 191 AIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKiFCGQiwpvdQQIYYKSYFLFI 270
Cdd:cd15000   92 AVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKNFLET-YCAE-----NTQVLPIYWHVI 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 271 FGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQiRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRD 342
Cdd:cd15000  166 ITVLVWLPLGIMLICYSAIFWKLDKYERRVLRREH-PSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRY 236
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
106-382 3.25e-17

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 81.27  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIaaLARYKKLR--NLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLY 183
Cdd:cd15375   10 IFIVGFPGNIIAI--FVYLFKMRpwKSSTIIMLNLALTDLLY-VTSLPFLIYYYINGE-SWIFGEFMCKFIRFIFHFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 VSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIA--LVWVVSILVAIPSAYFTTETvlvivKSQEKIFCGQIWPVD--Q 259
Cdd:cd15375   86 GSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVAcaVVWVISLAEVSPMTFLITTK-----EKNNRTICLDFTSSDnlN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGieFVGPVVTMTLCYARISRELwfkaVPGFQTeQIRKRLRCRRKTVLvlmcILTAYVLCWAPFYGFAI 339
Cdd:cd15375  161 TIWWYNWILTVLG--FLLPLVIVTLCYTRIIYTL----AKGPHT-GSASKQKARRLIIL----ILLVFYVCFLPFHILRV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 340 VRDFF---PTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd15375  230 VRIETrlpPVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDN 275
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
103-335 3.94e-17

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 81.41  E-value: 3.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpfemdYYVVRQLSWEHGH------VLCASVNY 176
Cdd:cd15385    7 LAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAF--------FQVLPQLCWDITYrfygpdFLCRIVKH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSaYFTTETVLVIVKSQEKIFCG--- 252
Cdd:cd15385   79 LQVLGMFASTYMLVMMTADRYIAICHPLKTlQQPTKRSYLMIGSAWALSFILSTPQ-YFIFSLSEIENGSGVYDCWAnfi 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVdqqiyyKSYFLFIFGIEFVGPVVTMTLCYARISRELWfKAVPGFQTEQIRKRL-----------------RCRRK 315
Cdd:cd15385  158 VPWGI------KAYITWITISIFVVPVIILLTCYGFICYNIW-RNIKCKTRRGLSDNAlknillavcvssvktisRAKIR 230
                        250       260
                 ....*....|....*....|
gi 528968953 316 TVLVLMCILTAYVLCWAPFY 335
Cdd:cd15385  231 TVKMTFVIVLAYIVCWAPFF 250
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
102-372 4.25e-17

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 80.95  E-value: 4.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTV 180
Cdd:cd15162    5 AVYTLVFVVGLpANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVI-WLPFKIAYHIHGN-NWIFGEALCRLVTVAFYG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPsaYFTTETVLVIVKSQeKIFCGQIWPVD 258
Cdd:cd15162   83 NMYCSILLLTCISIDRYLAIVHPMGHRRlrARRYALGTCLAIWLLALLVTLP--LYLVKQTIFLPALD-ITTCHDVLPEQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 QQI-YYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQteqiRKRLRCRRKTVLVlmciLTAYVLCWAPFYGF 337
Cdd:cd15162  160 LLVgDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSE----KKKKRAIKLAATV----LAIFIICFAPSNLL 231
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 528968953 338 AIVRDFFPTvFVKEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15162  232 LLAHYSLIS-SSGTGHLYFAYLLALCLSTLNSCID 265
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
107-382 6.01e-17

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 80.68  E-value: 6.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 107 MLVCG---IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFE-MDYYVVrqlSWEHGHVLCASVNYLRTVSL 182
Cdd:cd15092    8 LIVCVvglVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQgTDIFLG---FWPFGNALCKTVIAIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRP---RMKYQtATGLIALVWVVSILVAIPSAYFTTETVlvivkSQEKIFCGQIWPVDQ 259
Cdd:cd15092   84 FTSTFTLTAMSVDRYVAICHPIKAldvRTPHK-AKVVNVCIWALASVVGVPVMVMGSAQV-----EDEEIECLVEIPTPQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKrlrCRRKTVLVLMcILTAYVLCWAPFYGFAI 339
Cdd:cd15092  158 DYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRN---LRRITRLVLV-VVAVFVGCWTPIQIFVL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 340 VRdffpTVFVKEKHYLTAFYVVECIAMS--NSMINTVCFVTVKNN 382
Cdd:cd15092  234 AQ----GLGVQPSSETAVAILRFCTALGyvNSSLNPVLYAFLDEN 274
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
101-343 7.50e-17

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 80.72  E-value: 7.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDyYVVRQLsWEHGHVLCASVNYLRTV 180
Cdd:cd15958    7 MALIVLLIV--AGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGAT-LVVRGR-WLYGSFFCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPS--AYFTTETVLVIVKSQEKIFCGQIwp 256
Cdd:cd15958   83 CVTASIETLCVIAIDRYLAITSPFRYQslLTRARAKGIVCTVWAISALVSFLPimMHWWRDEDDQALKCYEDPGCCDF-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 vdqqIYYKSYFLFIFGIEFVGPVVTMTLCYARISRE---------------LWFKAVPGFQTEQIRKRLRCRR--KTVLV 319
Cdd:cd15958  161 ----VTNRAYAIASSIISFYIPLLIMIFVYLRVYREakkqikkidkcegrfHNTLTGLGRKCKRRPSRILALReqKALKT 236
                        250       260
                 ....*....|....*....|....
gi 528968953 320 LMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd15958  237 LGIIMGVFTLCWLPFFLVNVVNVF 260
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
132-376 1.56e-16

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 79.41  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 132 NLLIANLAISDFLVAIvCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP--RMK 209
Cdd:cd14991   36 TVYLFNLVLADFLLLI-CLPFRIDYYLRGE-HWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRvnRMS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 210 YQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQIYYKsyflfIFGIEFVGPVVTMTLCYARI 289
Cdd:cd14991  114 VKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIRWHNA-----LFLLEFFLPLGLIVFCSVRI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 290 SRELWfkavpgfQTEQIRKRLRCRRKTVLVLMcILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMS-- 367
Cdd:cd14991  189 ACNLR-------IRQSLGKQARVQRAIRLVFL-VVIVFVLCFLPSIIAGLLALVFKNLGSCRCLNSVAQLFHISLAFTyl 260
                        250
                 ....*....|.
gi 528968953 368 NSMINTV--CF 376
Cdd:cd14991  261 NSALDPViyCF 271
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
103-335 1.60e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 78.89  E-value: 1.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15052    6 LLLLLVIATIgGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSI-LTELFGGVWPLPLVLCLLWVTLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPSAYFTTETVLVIVKSQEkifCGQiwPVDQ 259
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFlkIAIVWLISIGISSPIPVLGIIDTTNVLNNGT---CVL--FNPN 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 260 QIYYKSYFLFIFgiefvgPVVTMTLCYARISRElwfkavpgfqteqirkrLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15052  160 FVIYGSIVAFFI------PLLIMVVTYALTIRL-----------------LSNEQKASKVLGIVFAVFVICWCPFF 212
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
97-343 1.62e-16

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 79.46  E-value: 1.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLsWEHGHVLCASVNY 176
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGA-IELVNNR-WIYGETFCLVRTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIV-HPLRPRMKYQTATGLIALVWVVSILVA-IPsayFTTETVLVIVKSQEKIFCGQI 254
Cdd:cd15056   79 LDVLLTTASIMHLCCIALDRYYAICcQPLVYKMTPLRVAVMLGGCWVIPTFISfLP---IMQGWNHIGIEDLIAFNCASG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIS----------RELWFKAVPGFQTEQIRK-RLRCRRKTVLVLMCI 323
Cdd:cd15056  156 STSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYvaareqahqiRSLQRAGSSNHEADQHRNsRMRTETKAAKTLGII 235
                        250       260
                 ....*....|....*....|
gi 528968953 324 LTAYVLCWAPFYGFAIVRDF 343
Cdd:cd15056  236 MGCFCVCWAPFFVTNIVDPF 255
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
101-346 2.32e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 78.71  E-value: 2.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCA---SVNYL 177
Cdd:cd15295    7 MSLLALVIV--LGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTL--TNRWDFGRGLCVfwlVIDYL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 R-TVSLYvstNALLaIAIDRYLAIVHPLRPRMKyQTATglialVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15295   83 LcTASVY---NIVL-ISYDRYQSVSNAVSYRNQ-QTAT-----LRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECEP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 vdqQIYYKSYFLFIFGI-EFVGPVVTMTLCYARISRELWfkavpgfqteqirKRLRcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15295  153 ---EFFSNWYILAITSVlEFLVPVILVAYFNTQIYWSLW-------------KRLR-DRKLAKSLAIILGTFAICWAPYS 215
                        250
                 ....*....|.
gi 528968953 336 GFAIVRDFFPT 346
Cdd:cd15295  216 LFTIIRAACEK 226
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
101-230 2.35e-16

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 79.04  E-value: 2.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTV 180
Cdd:cd15212    5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAF-LTLFSRPGWLFGDRLCLANGFFNAC 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15212   84 FGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLP 133
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
112-387 2.44e-16

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 79.12  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLL---IANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNA 188
Cdd:cd15355   16 VGNSITLYTLARKKSLQHLQSTVhyhLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFLRDACTYATALN 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 189 LLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPsAYFTTETVLVIVKSQEKIFCGQIWPVDQQIYYKSY 266
Cdd:cd15355   96 VASLSVERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIP-MLFTMGEQNRSGTHPGGLICTPIVDTSTLKVVIQV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 267 FLFifgIEFVGPVVTMTLCYARISREL-----------WFKAVPGFQTEQIRK----RLRCRRKTVLVLMCILTAYVLCW 331
Cdd:cd15355  175 NAF---LSFLFPMLVISVLNTLIANQLtvmvnqaeqenQVCTIGGQRTVLSVSmepgRVQSLRHGVLVLRAVVIAFVVCW 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 332 APFYG----FAIVRDFFPTVFVKE-KHYltaFYVV-ECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15355  252 LPYHVrrlmFCYVSDEQWTTFLYDfYHY---FYMLtNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
97-375 2.88e-16

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 78.31  E-value: 2.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCasvNY 176
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLD--VWIFGHTWC---QI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALL---AIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSayfttetvLVIVKSQEKIFC 251
Cdd:cd15063   76 WLAVDVWMCTASILnlcAISLDRYLAITRPIRYPslMSTKRAKCLIAGVWVLSFVICFPP--------LVGWNDGKDGIM 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIWPVD-----QQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRElwfkavpgfqteqirkrLRCRRKTVLVLMCILTA 326
Cdd:cd15063  148 DYSGSSSlpctcELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRA-----------------ARMETKAAKTVAIIVGC 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 327 YVLCWAPFYGFAIVRDFFPTVfVKEKHYLTAFYVVECIAMSNSMINTVC 375
Cdd:cd15063  211 FIFCWLPFFTVYLVRAFCEDC-IPPLLFSVFFWLGYCNSALNPCIYALF 258
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
99-382 3.20e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 78.41  E-value: 3.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccPFEMDYYVVRQLSWEHGHVLCASVNYLR 178
Cdd:cd15402    3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIY--PYPLVLTSIFHNGWNLGYLHCQISGFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQIwp 256
Cdd:cd15402   81 GLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLcyVLLIWVLTVAAIVPNLFVGS------LQYDPRIYSCTF-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 vdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelWFKAVpgfqteQIRKRLRCRRKTVL---------VLMCILTAY 327
Cdd:cd15402  153 --AQSVSSAYTIAVVFFHFILPIIIVTFCYLRI----WILVI------QVRRRVKPDNKPKLkphdfrnfvTMFVVFVLF 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 328 VLCWAP--FYGFAIVRDFFPTV-FVKEKHYLTAFYvvecIAMSNSMINTVCFVTVKNN 382
Cdd:cd15402  221 AVCWAPlnFIGLAVAVDPETIVpRIPEWLFVASYY----MAYFNSCLNAIIYGLLNQN 274
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
97-335 5.18e-16

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 77.78  E-value: 5.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVvRQLSWEHGHVLCASVNY 176
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLAL-PGRIAYYA-LGFDWPFGDWLCRLTAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR-PRM-KYQTATGLIALVWVVSILVAIPSAYFTtetvlVIVKSQEKIFCGQi 254
Cdd:cd15159   79 LFYINTYAGVNFMTCLSVDRYIAVVHPLRrHRLrKVKVVRYICVFVWVLVFLQTLPLLFMP-----MTKEMGGRITCME- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFG-IEFVGPVVTMTLCYARISRELWFKAvpgfQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15159  153 YPNFEKIKRLPLILLGACvIGFGVPVGIILFCYSQITLKLCRTA----KENPLTEKSGHHKKACNVILLVLLVFVVCFSP 228

                 ..
gi 528968953 334 FY 335
Cdd:cd15159  229 YH 230
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
99-335 5.70e-16

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 78.00  E-value: 5.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLR 178
Cdd:cd15131    3 ITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDL-YRLWQYRPWNFGDLLCKLFQFVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSayftteTVLVIVKSQEKIFcgqiwP 256
Cdd:cd15131   81 ESCTYSTILNITALSVERYFAICFPLRAKvvVTKRRVKLVILVLWAVSFLSAGPI------FVLVGVEHENGTN-----P 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQ------QIYYKSYFLFIF----GIEFVGPVVTMTLCYARISRELWFK----AVPGfqteqIRKRLRCRRKTVLVLMC 322
Cdd:cd15131  150 IDTneckatEYAVRSGLLTIMvwvsSVFFFLPVFCLTVLYSLIGRKLWRRrrenIGPN-----ASHRDKNNRQTVKMLAV 224
                        250
                 ....*....|...
gi 528968953 323 ILTAYVLCWAPFY 335
Cdd:cd15131  225 VVFAFVLCWLPFH 237
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
98-374 6.51e-16

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 77.01  E-value: 6.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLC---AS 173
Cdd:cd15331    1 VLTSIILGLLILATiIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQH--WFLGPEVCdmwIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSlyvSTNALLAIAIDRYLAI--VHPLRPRMKYQTATgLIALVWVVSILVAIPSAY-FTTETVLVIVKSQEKIF 250
Cdd:cd15331   79 MDVLCCTA---SILHLVAIALDRYWAVtnIDYIRRRTAKRILI-MIAVVWFVSLIISIAPLFgWKDEDDLDRVLKTGVCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQiwpvdqqiyYKSYFLFIFGIEFVGPVVTMTLCYARISrelwfkavpgfqteQIRKRlrcRRKTVLVLMCILTAYVLC 330
Cdd:cd15331  155 ISQ---------DYGYTIFSTVGAFYVPLLLMIIIYWKIY--------------QAAKR---ERKAARTLAIITGAFVVC 208
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 331 WAPFYGFAIVRDFFPTvfvkEKHYLTAFYVVECIAMSNSMINTV 374
Cdd:cd15331  209 WLPFFLVALVMPFCGA----WQISRFLESFFLWLGYFNSLLNPI 248
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
97-335 7.02e-16

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 76.91  E-value: 7.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQlSWEHGHVLCASVNY 176
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSI-MYIVKE-TWIMGQVVCDIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYFTTETVlvivkSQEkifcgqi 254
Cdd:cd15334   79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRtpKHAGIMIAVVWIISIFISMPPLFWRHQTT-----SRE------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wpvDQQIYYKSYFLF----IFGIEFVGPVVTMTLCYarisrelwfkavpgfqteQIRKRLRCRRKTVLVLMCILTAYVLC 330
Cdd:cd15334  147 ---DECIIKHDHIVFtiysTFGAFYIPLALILILYY------------------KIYRAATRERKAATTLGLILGAFVIC 205

                 ....*
gi 528968953 331 WAPFY 335
Cdd:cd15334  206 WLPFF 210
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
106-387 8.96e-16

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 76.73  E-value: 8.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFeMDYYVVRQlsWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15173    9 VMFVTGlVGNSLVIVIYIFYEKLRTLTDIFLVNLAVAD-LLFLCTLPF-WAYSAAHE--WIFGTVMCKITNGLYTINLYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRPRM---KYQTATGLIA-LVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQIWPVDQQ 260
Cdd:cd15173   85 SMLILTCITVDRFIVIVQATKAHNchaKKMRWGKVVCtLVWVISLLLSLPQFIYSE------VRNLSSKICSMVYPPDAI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 IYYKSYFLFIFGieFVGPVVTMTLCYARISRELWFKAvpGFQteqirkrlrcRRKTVLVLMCILTAYVLCWAPfYGFAIV 340
Cdd:cd15173  159 EVVVNIIQMTVG--FFLPLLAMIICYSVIIKTLLHAK--GFQ----------KHKSLKIIFVVVAVFILTQLP-YNIMKL 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 341 RDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15173  224 IRTLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
94-340 1.02e-15

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 76.76  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  94 AAKIVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCAS 173
Cdd:cd15333    2 GLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTG--TWTLGQVVCDI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlviVKSQEKIFC 251
Cdd:cd15333   80 WLSSDITCCTASILHLCVIALDRYWAITDAVEysKKRTPKRAAVMIALVWVISISISLPPFFWRQ------AKAEEEVSE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIwpVDQQIYYKSYFLFifgIEFVGPVVTMTLCYARISRElwfkavpgfqteqIRKRlrcRRKTVLVLMCILTAYVLCW 331
Cdd:cd15333  154 CVV--NTDHILYTVYSTV---GAFYIPTLLLIALYGRIYVE-------------ARAR---ERKATKTLGIILGAFIVCW 212

                 ....*....
gi 528968953 332 APFYGFAIV 340
Cdd:cd15333  213 LPFFIISLV 221
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
106-335 1.15e-15

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 77.18  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15133   10 IFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YELWQNYPFLLGSGGCYFKTFLFETVCLAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIP--SAYFTTETVLVIVKSQEKIFCGQIWPVDQQI 261
Cdd:cd15133   89 ILNVTALSVERYIAVVHPLAARTcsTRPRVTRVLGCVWGVSMLCALPntSLHGIKFLGSGVPASAQCTVRKPQAIYNMIP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 262 YYKSYFLFIFgiefvGPVVTMTLCYA---RISRE-----LWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15133  169 QHTGHLFFVL-----PMAVISVLYLLmalRLARErgldaTGAGSKIGTRTGQLLQHPRTRAQVTKMLFILVVVFAICWAP 243

                 ..
gi 528968953 334 FY 335
Cdd:cd15133  244 FH 245
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
103-377 1.24e-15

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 77.16  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFemdyyvvrQLSWEH-------GHVLCASV 174
Cdd:cd15198    6 FLGVILVAGvAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALS--------QIIWELlgdrwmaGDVACRLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKyqtATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQE--KIFCG 252
Cdd:cd15198   78 KLLQASARGASANLVVLLALDRHQAIRAPLGQPLR---AWKLAALGWLLALLLALPQAYVFRVDFPDDPASAWpgHTLCR 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRL--------------RCRRKTVL 318
Cdd:cd15198  155 GIFAPLPRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPskshlratapsalpRAKVKTLK 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 319 VLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYltafYVVECIAMSNSMINTVCFV 377
Cdd:cd15198  235 MTLVIALLFVGCSLPYFIAELAAAFGSGDWEPEKVA----AALGVMAVANSATNPFVFL 289
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
97-343 1.93e-15

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 76.33  E-value: 1.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNY 176
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTV--ETCWYFGDLFCKFHTG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQI 254
Cdd:cd15317   79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRypSKITVQVAWRFIAIGWLVPGIYTFGLIYTGA------NDEGLEEYSSEI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQ-QIYYKSYFLFIFGIEFVGPVVTMTLCYARI------------SRELWFKAVPGFQTEQIRKRLRCRRKTVLVLM 321
Cdd:cd15317  153 SCVGGcQLLFNKIWVLLDFLTFFIPCLIMIGLYAKIflvarrqarkiqNMEDKFRSSEENSSKASASRERKAAKTLAIVM 232
                        250       260
                 ....*....|....*....|..
gi 528968953 322 CIltaYVLCWAPFYGFAIVRDF 343
Cdd:cd15317  233 GI---FLFCWLPYFIDTIVDEY 251
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
97-376 1.98e-15

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 75.60  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLG--YWAFGRIFCDVWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTETVlvivkSQEKIFCGqi 254
Cdd:cd15062   79 VDVLCCTASIMSLCVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVISIGPLLGWKEPA-----PADEQACG-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wpVDQQiyyKSYFLFIFGIEFVGPVVTMTLCYARISRelwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15062  152 --VNEE---PGYVLFSSLGSFYLPLAIILVMYCRVYV--------------VAFKFSREKKAAKTLGIVVGAFVLCWFPF 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528968953 335 YGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15062  213 FVVLPLGSLFSTLKPPE----PVFKVVFWLGYFNSCLNPIIY 250
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
98-382 2.16e-15

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 76.01  E-value: 2.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKlRNLTNLLIANLAISDfLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15339    1 VILPSFIGILCSTGlVGNILVLFTIIRSRK-KTVPDIYVCNLAVAD-LVHIIVMPFLI-HQWARGGEWVFGSPLCTIITS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR-PRMKYQTATGLIAL-VWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQI 254
Cdd:cd15339   78 LDTCNQFACSAIMTAMSLDRYIALVHPFRlTSLRTRSKTIRINLlVWAASFILVLPVWVYAK----VIKFRDGLESCAFN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYARI---SRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMcILTAYVLCW 331
Cdd:cd15339  154 LTSPDDVLWYTLYQTITT--FFFPLPLILICYILIlcyTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLV-LVGVFLVSA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528968953 332 APFYGFAIV--RDFFPTVfvkekHYLTAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd15339  231 APYHVIQLVnlSVSQPTL-----AFYVSYYLSICLSYASSSINPFLYILLSGN 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
113-380 2.86e-15

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 75.39  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFeMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:cd15178   17 GNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTL-PF-WAVSVVKG--WIFGTFMCKLVSLLQEANFYSGILLLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLRPRMKYQTATGLI-ALVWVVSILVAIPSAYFTTETVLVivkSQEKIFCGQ--------IWPVDQQIyy 263
Cdd:cd15178   93 SVDRYLAIVHATRALTQKRHLVKFVcAGVWLLSLLLSLPALLNRDAFKPP---NSGRTVCYEnlgnesadKWRVVLRI-- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 ksyFLFIFGieFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRlrcrrKTVLVLMCILTAYVLCWAPFYGFAIVRDF 343
Cdd:cd15178  168 ---LRHTLG--FLLPLVVMLFCYGFTIKTL-------LQTRSFQKH-----RAMRVIFAVVLAFLLCWLPYNVTVLIDTL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 344 FPTVFVKE-----KHYLTAFYVVECIAMSNSMINTV--CFVTVK 380
Cdd:cd15178  231 MRTKLITEtcelrNHVDVALYVTQILGFLHSCINPVlyAFIGQK 274
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
113-372 5.30e-15

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 74.77  E-value: 5.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVcCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:cd15087   17 GNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPINIAEHLLQQ--WPFGELLCKLILSIDHYNIFSSIYFLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLRP-RMKYQT--ATGLIAL-VWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQIWPVDQQIYYKSYFL 268
Cdd:cd15087   94 SVDRYLVVLATVRSrRMPYRTyrAAKIVSLcVWLLVTIIVLPFTVFAG----VYSNELGRKSCVLSFPSPESLWFKASRI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 269 FIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRcRRKTVLVLMcILTAYVLCWAPFY---GFAIVRDFFP 345
Cdd:cd15087  170 YTLVLGFAIPVSTICILYTMMLYKL--RNMRLNSNAKALDKAK-KKVTLMVLV-VLAVCLFCWTPFHlstVVALTTDLPQ 245
                        250       260
                 ....*....|....*....|....*..
gi 528968953 346 TVFVkekhyLTAFYVVECIAMSNSMIN 372
Cdd:cd15087  246 TPLV-----IGISYFITSLSYANSCLN 267
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
102-376 5.40e-15

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 74.80  E-value: 5.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYvvrQLSWEHGHVLCASVNYLRTV 180
Cdd:cd15923    5 AIYIPTFVLGlLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISL-PFKMHSY---RRESAGLQKLCNFVLSLYYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPsaYFTTETvlvivkSQEKIFCGQiwPVD 258
Cdd:cd15923   81 NMYVSIFTITAISVDRYVAIRYPLRARELRSPrkAAVVCAVIWVLVVTISIP--YFLLDS------SNEKTMCFQ--RTK 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 QQIYYKSYFLFIFgIEFVGPVVTMTLCYARISRELwfkavpgfqteQIRKRLRCRRKTVLVLMCILTA----YVLCWAPF 334
Cdd:cd15923  151 QTESLKVFLLLEI-FGFLLPLIIMTFCSARVIHTL-----------QKRLDDVGSRSETKQCIRVIMAnlivFIVCFLPV 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 335 YGFAIVRDFFPTVF--VKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15923  219 HVGFFVKFIVGKSYscDSKLIIHFFLQSAFCLSDMNCCLDAFCY 262
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
98-374 5.45e-15

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 74.70  E-value: 5.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKlrnlTNLLIANLAISDFLVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYL 177
Cdd:cd15201    6 VLILEFVLGLLGNGLALWIFCFHLKSWKS----STVYLFNLAVADFLL-IICLPFRTDYYL-RGKHWKFGDIPCRIVLFM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVaipSAYFTTETVLVIVK--SQEKIFCGQ 253
Cdd:cd15201   80 LAMNRAGSIFFLTAVAVDRYFRVVHPHHRinSISVRKAAIIACGLWLLTIAM---TVYLLTKKHLFPRGnaTQCESFNIC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQIYYKSYFLFifgiEFVGPVVTMTLCYARISRELWFKAVPgfQTEQIRKRLRCrrktvlvLMCILTAYVLCwap 333
Cdd:cd15201  157 TGTDSSSNWHEAMFLL----EFFLPLAIILYCSVRIIWQLRGRQLD--RHAKIKRAVQF-------IMVVAIVFIIC--- 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 334 fygfaivrdFFPTVFVK-----EKHYL-----------TAFYVVECIAMSNSMINTV 374
Cdd:cd15201  221 ---------FLPSNVTRiaiwiLKHTSnedcqyyrsvdLAFYITISFTYFNSMLDPV 268
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
103-335 5.49e-15

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 75.18  E-value: 5.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNlTNLLIANLAISDfLVAIVCCPFeMDYYVVRQLSWEHGHVLCASVNYLRTVSL 182
Cdd:cd15190   19 LVFVLGLSGNGLVLWTVFRSKRKRRRS-ADTFIANLALAD-LTFVVTLPL-WAVYTALGYHWPFGSFLCKLSSYLVFVNM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVAIPSAYFTTETVL-------------VIVKSQE 247
Cdd:cd15190   96 YASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALgvIWLLAALLALPALILRTTSDLegtnkvicdmdysGVVSNES 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 248 KIFcgqiWPVDQQIYYKSyflfifgIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLmciltAY 327
Cdd:cd15190  176 EWA----WIAGLGLSSTV-------LGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVV-----TF 239

                 ....*...
gi 528968953 328 VLCWAPFY 335
Cdd:cd15190  240 ALCWLPFH 247
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
102-392 6.66e-15

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 74.60  E-value: 6.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCG--IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVrqlswehGHVLCASVNYLRT 179
Cdd:cd15307    4 ALLALVLVLGtaAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVK-------GHFPLSSEHCLTW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYV-----STNALLAIAIDRYLAIVHPLR-PRMKYQTATGL-IALVWVVSILVAIP-SAYFTTETVLVIVKSQekifC 251
Cdd:cd15307   77 ICLDVlfctaSIMHLCTISVDRYLSLRYPMRfGRNKTRRRVTLkIVFVWLLSIAMSLPlSLMYSKDHASVLVNGT----C 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 gqiwpvdqQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCW 331
Cdd:cd15307  153 --------QIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLL------ARQRSRHGRIIRLEQKATKVLGVVFFTFVILW 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 332 APFYgfaiVRDFFPTVFVKEKHYLT--AFYVVECIAMSNSMINTVcFVTVKNNTIKY-FKKIML 392
Cdd:cd15307  219 SPFF----VLNLLPTVCAECEERIShwVFDVVTWLGYASSMVNPI-FYTIFNKVFRQaFKKVLL 277
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
129-335 8.65e-15

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 74.45  E-value: 8.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 129 NLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-- 206
Cdd:cd15374   33 NPTTVYMFHLALSDTLY-VLSLPTLIYYYADHN-HWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRAlr 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 207 RMKYQTATGLIALVWVVSILVAIPSAYFTT-----ETVLVIVKSQEKIFcgqiwpvDQQIYYKSYFL-FIFGIefvgPVV 280
Cdd:cd15374  111 WVKPRHAYLICASVWLVVTVCLVPNLIFVTtsrkdNITLCHDTTRPEEF-------DHYVHYSSAVMvLLFGI----PCL 179
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 281 TMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVlmciLTAYVLCWAPFY 335
Cdd:cd15374  180 VIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMV----LTVFAICFVPFH 230
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
97-352 9.16e-15

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 73.62  E-value: 9.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCasvNY 176
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGK--WLFGIHLC---QM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALL---AIAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIP--------SAYFTTETVLVIv 243
Cdd:cd15060   76 WLTCDILCCTASILnlcAIALDRYWAIHDPINYAQKRTLKRVLlmIVVVWALSALISVPpligwndwPENFTETTPCTL- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 244 kSQEKIFCgqiwpvdqqIYYKSYFLFIfgiefvgPVVTMTLCYARIsrelwFKAvpgfqTEQIRKRLRcrrktvlVLMCI 323
Cdd:cd15060  155 -TEEKGYV---------IYSSSGSFFI-------PLLIMTIVYVKI-----FIA-----TSKERRAAR-------TLGII 200
                        250       260
                 ....*....|....*....|....*....
gi 528968953 324 LTAYVLCWAPFYGFAIVRDFFPTVFVKEK 352
Cdd:cd15060  201 MGVFVVCWLPFFLMYVILPFCETCSPSAK 229
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
112-334 1.19e-14

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 73.63  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVrqlSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15181   16 VGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIA---GWVFGTFLCKLVGAIHKLNFYCSSLLLAC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPL------RPRMKYQTATGLialvWVVSILVAIPSAYF------TTETVLVIVKSQEKIFCGQIWPVDQ 259
Cdd:cd15181   92 ISVDRYLAIVHAIhsyrhrRLRSVHLTCGSI----WLVCFLLSLPNLVFlevetsTNANRTSCSFHQYGIHESNWWLTSR 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 260 QIYYKSYFLFifgiefvgPVVTMTLCYARISRELWfkavpgfqteQIRKRLRcRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15181  168 FLYHVVGFFL--------PLLIMGYCYATIVVTLC----------QSSRRLQ-KQKAIRVAILVTLVFCLCWLPY 223
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
106-382 1.19e-14

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 73.69  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15921   10 IFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYYV-LNSHWPFGDIACRIILYVLYVNMYSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRP-RMKYQTATGLI-ALVWVVSILVAIPSAYFTTETVlviVKSQEKIFCGQIWPVDqQIYY 263
Cdd:cd15921   88 IYFLTALSVFRYLALVWPYLYlRVQTHSVAGIIcGLIWILMGLASSPLLFAKSKQH---DEGSTRCLELAHDAVD-KLLL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGieFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLR-CRRKTVLVLMCILTAYVLCWAPFYgfaIVRD 342
Cdd:cd15921  164 INYVTLPVG--FVVPFMTVIFCYIFIIKNL-------LKPSPALGRTRpSRRKACALIIISLGIFLVCFLPYH---IVRT 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 343 FFPTVFVKEKHYL-------TAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd15921  232 IHLITERQIKESCgyilrvrKAAVITLCLAASNSCFDPLLYFFVGEN 278
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
103-335 1.20e-14

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 73.81  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVcgIGNFIFIAALARYKKLRNLTN-LLIANLAISDFLVAI------VCCPFEMDYYVVRQLSWEHgHVLCASVN 175
Cdd:cd14980    9 IIGILAL--IGNILVIIWHISSKKKKKKVPkLLIINLAIADFLMGIylliiaIADQYYRGRYAQYSEEWLR-SPPCLLAC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSI-LVAIPSAYFTTETVLVIVKSQEKIfCgq 253
Cdd:cd14980   86 FLVSLSSLMSVLMMLLITLDRYICIVYPFSNkRLSYKSAKIILILGWLFSIiFAAIPILYSINQPGDNRLYGYSSI-C-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 iWPVD-QQIYYKSYFLFIFGIEFVGpVVTMTLCYARIsrelwFKAVpgFQTEQIRKRLRCRRKTVLV--LMCILTAYVLC 330
Cdd:cd14980  163 -MPSNvSNPYYRGWLIAYLLLTFIA-WIIICILYILI-----FISV--RKSRKSARRSSSKRDKRIAirLALILITDLIC 233

                 ....*
gi 528968953 331 WAPFY 335
Cdd:cd14980  234 WLPYY 238
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
97-382 1.27e-14

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 73.85  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEM-DYYVVRQLSWEHGHVLCASVN 175
Cdd:cd15074    1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIiSAFAHRWLFGDIGCVFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSlyvSTNALLAIAIDRYLAIVHP-LRPRMKYQTATGLIALVWVVSILVAIPS----AYFTTETVLVIvksqekif 250
Cdd:cd15074   81 FLFGCC---SINTLTAISIYRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVAPlvgwGSYGPEPFGTS-------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPVDQQ-IYYKSYFLFIFGIEFVGPVVTMTLCYARISREL--WFKAVPGFQTeQIRKRLRCRRKTVLVLMCILTAY 327
Cdd:cd15074  150 CSIDWTGASAsVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVksSRKRVAGFDS-RSKRQHKIERKVTKVAVLICAGF 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 328 VLCWAPfygFAIVRdfFPTVFVKEKHYLTAFYVVECI-AMSNSMINTVCFVTVKNN 382
Cdd:cd15074  229 LIAWTP---YAVVS--MWSAFGSPDSVPILASILPALfAKSSCMYNPIIYLLFSSK 279
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
97-376 1.35e-14

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 73.39  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGY--WAFGRVFCNIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVAIPSAYFTTETVlvivkSQEKIFCgqi 254
Cdd:cd15325   79 VDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALlcVWVLSLVISIGPLFGWKEPA-----PEDETIC--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wpvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAVPGFQTEqirkrlrcrRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15325  151 ----QITEEPGYALFSALGSFYLPLAIILVMYCRV-----YVVALKFSRE---------KKAAKTLGIVVGCFVLCWLPF 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528968953 335 YGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15325  213 FLVMPIGSIFPAYKPSD----TVFKITFWLGYFNSCINPIIY 250
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
119-341 1.80e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 73.29  E-value: 1.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 119 AALARYKKLRNLTNLLIaNLAISDFLVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYL 198
Cdd:cd15366   24 AAYLQVRQRNELGVYLL-NLSVSDLLY-IATLPLWIDYFL-HRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 199 AIVHPLR-PRMK-YQTATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFCGQIWPVDQQIYYKSYFLFIFGieFV 276
Cdd:cd15366  101 AVAHPLRfAKVRrVKTAVAVSAVVWAIEIGANSAPLFHDE----LFRDRYNHTFCFEKYPMEDWVAWMNLYRVFVG--FL 174
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 277 GPVVTMTLCYARIsrelwFKAVPGFQTEQIRKRLRCRRkTVLVLMCILtayVLCWAPFYGFAIVR 341
Cdd:cd15366  175 FPWVLMLFSYRGI-----LRAVRGNVSTEQQEKAKIKR-LALSLIAIV---LLCFAPYHVLLLSR 230
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
98-334 2.00e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 73.23  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEM--DYYVvrqlSWEHGHVLCASVN 175
Cdd:cd15073    2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAasDLHG----SWKFGYAGCQWYA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHP-LRPRMKYQTATGLIALVWVVSIL-VAIP----SAYFTTETVLVivksqeki 249
Cdd:cd15073   78 FLNIFFGMASIGLLTVVAVDRYLTICRPdLGRKMTTNTYTVMILLAWTNAFFwAAMPlvgwASYALDPTGAT-------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 fCGQIWPVDQQIyYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfKAVP-GFQTEQIRKRLRCRRKTVLVLMCILTAYV 328
Cdd:cd15073  150 -CTINWRKNDSS-FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFV--KKVLaSDCLESVNIDWTDQNDVTKMSVIMIVMFL 225

                 ....*.
gi 528968953 329 LCWAPF 334
Cdd:cd15073  226 VAWSPY 231
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
97-374 2.42e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 72.40  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIfiAALARYKK--LRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASV 174
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSI--VCLIVYQKpaMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITG--RWIFGDIFCRIS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPlRPRMKYQTATGLIALVWVVSILVAIPSAYFTTEtvLVIVKSQEKIFCGQI 254
Cdd:cd15213   77 AMLYWFFVLEGVAILLIISVDRYLIIVQR-QDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGK--YEFPPRAPQCVLGYT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGIefvgPVVTMTLCYARISRelwfkAVPGFQTEQIrkrlrcrrKTVLVLmciLTAYVLCWAPF 334
Cdd:cd15213  154 ESPADRIYVVLLLVAVFFI----PFLIMLYSYFCILN-----TVRSFKTRAF--------TTILIL---FIGFSVCWLPY 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 528968953 335 YGFAIVrdffpTVFVKekhYLTAFYVVECIAMSNSMINTV 374
Cdd:cd15213  214 TVYSLL-----SVFSR---YSSSFYVISTCLLWLSYLKSA 245
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
112-334 2.73e-14

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 72.89  E-value: 2.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfeMDYYVVRQLS-WEHGHVLCASVNYLRTVSLYVSTNALL 190
Cdd:cd15177   16 VGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLT-----LPFAAAETLQgWIFGNAMCKLIQGLYAINFYSGFLFLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 191 AIAIDRYLAIV-----HPLRPRMKYQTATGLIaLVWVVSILVAIPSAYFTTETvlvivKSQEKIFCGQIWP-VDQQIYYK 264
Cdd:cd15177   91 CISVDRYVVIVratsaHRLRPKTLFYSVLTSL-IVWLLSILFALPQLIYSRVE-----NRSELSSCRMIFPeVVSRTVKG 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLFIFGIEFVGPVVTMTLCYARISRELWfkAVPGFQteqirkrlrcRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15177  165 ATALTQVVLGFAIPLIVMAVCYAAIGRTLL--AARGWE----------RHRALRVIAALVVAFVLFQLPY 222
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
126-346 3.02e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 72.49  E-value: 3.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 126 KLRNLTNLLIANLAISDfLVAIVCCPFEMDYyVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR 205
Cdd:cd15367   30 KAKNELGIYLCNLTVAD-LLYIFSLPFWLQY-VLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 206 --PRMKYQTATGLIALVWVVSILVAIpsaYFTTETVLVIVKSQEKIfCGQIWPVDQQIYYKSYFLFIFGieFVGPVVTMT 283
Cdd:cd15367  108 fhAFRTMKAATLVSTVIWLKELMTCV---FFFLHGEISKDKENHSV-CFEHYPIKAWEHNINYYRFYAG--FLFPIFLLS 181
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528968953 284 LCYARIsrelwFKAVPGFQTEQIRKRLRCRRktvLVLMCILTaYVLCWAPFYGFAIVRDFFPT 346
Cdd:cd15367  182 FSYCRI-----LRAVRKSHGTQKSQKIQIKR---LVLSTVVI-FLVCFGPYHILLLVRSVFER 235
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
102-230 3.20e-14

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 73.26  E-value: 3.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYyVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15005    6 TLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAS-VRHGSGWIYGALSCKVIAFLAVLF 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHP--LRPRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15005   85 CFHSAFTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
98-334 3.44e-14

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 72.44  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYL 177
Cdd:cd15336    2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKR--WIFGEKGCELYAFC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIP-----SAYFTtetvlvivksqEKIF 250
Cdd:cd15336   80 GALFGITSMITLLAISLDRYLVITKPLASirWVSKKRAMIIILLVWLYSLAWSLPplfgwSAYVP-----------EGLL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWP-VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAV--PGFQTEQI-----------RKRLRCRRKT 316
Cdd:cd15336  149 TSCTWDyMTFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFI-----FLAIrsTGREVQKLgsqdrkekakqYQRMKNEWKM 223
                        250
                 ....*....|....*...
gi 528968953 317 VLVLMCILTAYVLCWAPF 334
Cdd:cd15336  224 AKIAFVVILLFVLSWSPY 241
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
105-377 3.49e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 72.53  E-value: 3.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15118    8 GIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSD-LLATLSLPF-FTYYLASGHTWELGTTFCRIHSSIFFLNMFV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlVIVKSQEKIFC----GQIWP-- 256
Cdd:cd15118   86 SGFLLAAISLDRCLLVVKPVwaQNHRNVAAAKKICGVIWAMALINTIPYFVFRD----VIERKDGRKLCyynfALFSPsp 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 --VDQQIYYKSYFLFI--FGIEFVGPVVTMTLCYARISrelwfkavpgfqteqIRKRLRCRRKT---VLVLMCILTAYVL 329
Cdd:cd15118  162 dnNHPICKQRQEGLAIskLLLAFLIPLVIIAVSYAVVS---------------LIIRHRCRRRPgrfVRLVVSVVVSFAL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFV 377
Cdd:cd15118  227 CWAPYHIFSIIEVMAHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYV 274
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
137-377 3.79e-14

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 72.05  E-value: 3.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 137 NLAISDFLvaivCC---PFeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT- 212
Cdd:cd15114   40 NLAVADLL----CClslPI-LAVPIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRAr 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 213 -ATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQQIYYK-SYFLFIFGieFVGPVVTMTLCYARIS 290
Cdd:cd15114  115 lAWIACGAAWLLALLLTVPSFIYRR---IHQEHFPEKTVCVVDYGGSTGVEWAvAIIRFLLG--FLGPLVVIASCHGVLL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 291 RELWFkavpgfqteqiRKRLRCRRKTVLVLMCILtAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSM 370
Cdd:cd15114  190 VRTWS-----------RRRQKSRRTLKVVTAVVV-GFFLCWTPYHVVGLIIAASAPNSRLLANALKADPLTVSLAYINSC 257

                 ....*..
gi 528968953 371 INTVCFV 377
Cdd:cd15114  258 LNPIIYV 264
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
92-377 4.33e-14

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 72.08  E-value: 4.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  92 FFAAKIVIGMAlvgimlvcgiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAivccpFEMDYYVVRQ-LSWEHGHVL 170
Cdd:cd15176    6 FYTIALVVGLA----------GNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLL-----FTLPFWAADAvNGWVLGTAM 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 171 CASVNYLRTVSLYVSTNALLAIAIDRYLAIVhplrpRMKYQTATGLIA-----LVWVVSILVAIPSAYFTTetvlvIVKS 245
Cdd:cd15176   71 CKITSALYTMNFSCGMQFLACISVDRYVAIT-----KATSRQFTGKHCwivclCVWLLAILLSIPDLVFST-----VREN 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 246 QEKIFCGQIWPVDQQIYYKSYFLFI-FGIEFVGPVVTMTLCYARISRELwfKAVPGFQteqirkrlrcRRKTVLVLMCIL 324
Cdd:cd15176  141 SDRYRCLPVFPPSLVTSAKATIQILeVLLGFVLPFLVMVFCYSRVARAL--SRTPNVK----------KSRALKVLLAVV 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 325 TAYVLCWAPFYGFAIVRDF-----FPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFV 377
Cdd:cd15176  209 GVFIVTQLPYNVVKFYRAIdviylLITDCSMSKTLDIAIQVTESIALFHSCLNPVLYV 266
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
97-335 4.58e-14

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 71.83  E-value: 4.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGY--WYFGSTWCAFYLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYFTTEtvlvivKSQEKIFCGQI 254
Cdd:cd15324   79 LDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRtpKRIKRMIAVVWVISAVISFPPLLMTKH------DEWECLLNDET 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WpvdqqiyyksYFLFIFGIEFVGPVVTMTLCYARISRElwfkavpgfqteqirKRLRCRRKTvLVLMCILTAYVLCWAPF 334
Cdd:cd15324  153 W----------YILSSCTVSFFAPGLIMILVYCKIYRV---------------AKMREKRFT-FVLAVVMGVFVLCWFPF 206

                 .
gi 528968953 335 Y 335
Cdd:cd15324  207 F 207
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
97-348 4.80e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 72.28  E-value: 4.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARyKKLRNLTNLLIANLAISDFLVAIVCCP-----FEMDYYVV--RQLSWEHGHV 169
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPlfllpYIADYSSSflSYFYAYFLPY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 170 LCASVNYLRTVSLYVstnaLLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSaYFTTETVLVIVKSQE 247
Cdd:cd14978   80 IYPLANTFQTASVWL----TVALTVERYIAVCHPLKARTwcTPRRARRVILIIIIFSLLLNLPR-FFEYEVVECENCNNN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 248 KIFCGQIWPVDQ--QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWfKAVPGFQTEQIRKRLRCR-----RKTVLVL 320
Cdd:cd14978  155 SYYYVIPTLLRQneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRALR-KSKKRRRLLRRRRRLLSRsqrreRRTTIML 233
                        250       260
                 ....*....|....*....|....*...
gi 528968953 321 MCILTAYVLCWAPFYGFAIVRDFFPTVF 348
Cdd:cd14978  234 IAVVIVFLICNLPAGILNILEAIFGESF 261
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
106-341 6.16e-14

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 71.71  E-value: 6.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFemdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15174   10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF-LCTLPF---WATAASSGWVFGTFLCKVVNSMYKINFYSC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRmKYQTATGLI-----ALVWVVSILVAIPSAYFTTetvlviVKSQEKI-FCGQIWPVDQ 259
Cdd:cd15174   86 MLLLTCISVDRYIAIVQATKAH-NSKNKRLLYsklvcFFVWLLSTILSLPEILFSQ------SKEEESVtTCTMVYPSNE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFI-FGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKrlrcrRKTVLVLMCILTAYVLCWAPFYGFA 338
Cdd:cd15174  159 SNRFKVAVLALkVTVGFFLPFVVMVICYTLIIHTL-------LQAKRFQK-----HKALKVIIAVVTVFVLSQLPYNSIL 226

                 ...
gi 528968953 339 IVR 341
Cdd:cd15174  227 LIK 229
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
112-387 6.89e-14

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 71.71  E-value: 6.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFemdYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15172   16 IGNSLVVITYAFYKRTKSMTDVYLLNMAIADILF-VLTLPF---WAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLAC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRpRMKYQTATGL-----IALVWVVSILVAIPSAYF------TTETVLVIVKSQEKIFCGQIWpvdqq 260
Cdd:cd15172   92 ISVDRYIAIVQATK-SFRLRSRTLAyskliCAAVWLLAILISLPTFIFsevydfGLEEQYVCEPKYPKNSTAIMW----- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 iyyKSYFLFI-FGIEFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAI 339
Cdd:cd15172  166 ---KLLVLSLqVSLGFFIPLLVMIFCYSFIIKTL------------LQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLL 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 340 VRD---FFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15172  231 IEAinlGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
133-333 7.26e-14

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 71.32  E-value: 7.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 133 LLIANLAISDFLVAIVCcPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KY 210
Cdd:cd15372   36 IFLINLAVADLLLILVL-PFKISYHFLGN-NWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTlrSR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 211 QTATGLIALVWVVSILVAIPsayFTTETVLVIVKSQEKIFCGQIWPVDQQI-YYKSYFLFIFGIEFVGPVVTMTLCYARI 289
Cdd:cd15372  114 RFALCMCTAIWLIAAALTLP---LTLQRQSYPLERLNITLCHDVLPLDEQDtYLFYYFACLAVLGFLLPLVVILFCYGSV 190
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 528968953 290 sreLWFKAVPGfqteqiRKRLRCRRKTVLVLMciltAYVLCWAP 333
Cdd:cd15372  191 ---LHTLLRSG------QRYGHAMKLTVLVLV----SFVLCFTP 221
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
113-340 7.56e-14

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 71.64  E-value: 7.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRN-LTNLLIANLAISDFLVAiVCCPFEMDYYVVRqLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15104   16 GNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVG-LAIPGLATDELLS-DGENTQKVLCLLRMCFVITSCAASVLSLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAipsayFTTETVLVIVKSQEKIFCGQIwpvdqQIYYKSYFLF 269
Cdd:cd15104   94 IAFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIG-----FLPLISPQFQQTSYKGKCSFF-----AAFHPRVLLV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 270 IFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRR---------KTVLVLMcilTAYVLCWAPFYGFAIV 340
Cdd:cd15104  164 LSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRrtlsdfkaaRTVAVLI---GCFLLSWLPFQITGLV 240
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
106-335 7.84e-14

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 71.72  E-value: 7.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15358   10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YEMWSNYPFLLGAGGCYFKTLLFETVCFAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSayftteTVLVIVkSQEKIFCGQIWP------- 256
Cdd:cd15358   89 ILNVTALSVERYIAVVHPLKAKyvVTRTHAKRVIGAVWVVSILCSIPN------TSLHGI-FQLTVPCRGPVPdsatcml 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISREL------------WFKAVPGFQTEQIRKRLRCRRKTVLVLMCIL 324
Cdd:cd15358  162 VKPRWMYNLIIQITTLLFFFLPMGTISVLYLLIGLQLkrekmllvleakGSKAGDSYQHRRIQQEKRRRRQVTKMLFVLV 241
                        250
                 ....*....|.
gi 528968953 325 TAYVLCWAPFY 335
Cdd:cd15358  242 VVFGICWAPFH 252
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
106-334 9.26e-14

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 71.75  E-value: 9.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGI-GNFIFIAALARYKK----LRNLTNLLIAnLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTV 180
Cdd:cd15135    9 LILVAGIlGNSATIKVTQVLQKkgylQKSVTDHMVS-LACSDLLVLLLGMPVELYSAIWDPFATPSGNIACKIYNFLFEA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATG-LIALVWVVSILVAIPSAYFT-TETVLVIVKS------------Q 246
Cdd:cd15135   88 CSYATILNVATLSFERYIAICHPFKYKALSGSRVRlLICFVWLTSALVALPLLFAMgTEDPLEAFPSyrgtrhhcqdqkS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 247 EKIFC---GQIWPVDQQIYYKSYFLFIFGIEFVGPVV-TMTLCYARISRELWFKAVPGFQTEQIRKR-----LRCRRKTV 317
Cdd:cd15135  168 NLTICtslSSKWTVFQASIFSAFVLYLLVLASVAFMCrRMMRALMGSKKGAVAVKGPGGSVQLLRKHesaegKTARKQTI 247
                        250
                 ....*....|....*..
gi 528968953 318 LVLMCILTAYVLCWAPF 334
Cdd:cd15135  248 LFLGLIVGTLAVCWMPN 264
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
103-340 9.83e-14

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 70.64  E-value: 9.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNYLRTVSL 182
Cdd:cd15215    6 IVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSV--PLFWPLDSHLCTALVVLMHLFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTEtvlvIVKSQEKIFCGQIWPVDQq 260
Cdd:cd15215   84 FAGVNTIVVVSVDRYLAIIHPLSypTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQ----AAFDERNALCSVIWGSSY- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 261 iyykSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAVpgfqteqiRKRLRCrrKTVLVLMCILTAYVLCWAPFYGFAIV 340
Cdd:cd15215  159 ----SYTILSVVSSFVLPVIIMLACYSMV-----FRAA--------RRCYHC--KAAKVIFIIIFSYVLSMGPYSFLSVL 219
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
97-380 1.39e-13

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 70.69  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVcgignFIFIAALARYKKlrNLTNLLIANLAISDFLVaIVCCPF-----EMDYyvvrqlSWEHGHVLC 171
Cdd:cd15926    9 VVCALGLVGNLLV-----LYLMKSKQGWKK--SSINLFVTSLAVTDFQF-VLTLPFwavenALDF------TWLFGKAMC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 172 ASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQ--TATGLIALVWVVSILVAIPSAYFTTET-----VLVIVK 244
Cdd:cd15926   75 KIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGccSAKWLCVLIWVLAILASLPNAIFSTTAtvsneELCLVK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 245 SQEKIFCGQIWpvdQQIYYKSYFLfifgIEFVGPVVTMTLCYARISRELWFKAVPGFQTeqiRKRLRCRRKTVLVLMcil 324
Cdd:cd15926  155 FPDNRGNAQFW---LGLYHAQKVL----LGFLIPLGIISLCYLLLVRFITDKNITGSST---KRRSKVTKSVTIVVL--- 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 325 tAYVLCWAP---FYGFAIVRDFFPTVFVKEkHYLT---AFYVVECIAMSNSMINTVCFVTVK 380
Cdd:cd15926  222 -SFFLCWLPnqaLTTWGILIKLNVVHFSYE-YFTTqvyIFPITVCLAHSNSCLNPILYCLMR 281
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
96-395 1.48e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 70.36  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  96 KIVIGMALVGIM-LVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASV 174
Cdd:cd15299    2 QVVLIAFLTGILaLVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMN--RWALGNLACDLW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTtetvlvivksqeKIFCG 252
Cdd:cd15299   80 LSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTkrAGVMIGLAWVISFVLWAPAILFW------------QYFVG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 Q-IWPVDQ-QIYYKSYFLFIFGI---EFVGPVVTMTLCYARISRelwfkavpgfqtEQIRKrlrcrRKTVLVLMCILTAY 327
Cdd:cd15299  148 KrTVPPDEcFIQFLSEPIITFGTaiaAFYLPVTIMTILYWRIYK------------ETIKE-----KKAAQTLSAILLAF 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 328 VLCWAPFYGFAIVRDFFPTVFVKekhylTAFYVVECIAMSNSMINTVCFVTVKNNTIKYFKKIMLLHW 395
Cdd:cd15299  211 IITWTPYNIMVLVNTFCDSCIPK-----TYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQC 273
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
101-372 2.01e-13

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 70.35  E-value: 2.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCAsvnyLRT- 179
Cdd:cd15314    7 LGLISLVTVCG--NLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSV--ETCWYFGDLFCK----IHSs 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 --VSLyvSTNALL---AIAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPsayFTTETVLVIVKSQEKIFCG 252
Cdd:cd15314   79 fdITL--CTASILnlcFISIDRYYAVCQPLLYRSKITVRVVLvmILISWSVSALVGFG---IIFLELNIKGIYYNHVACE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQ-QIYYKSYFLFIFGIefvgPVVTMTLCYARI-------SRELwfKAVPGFQTEQIRKRLRCRRKTVLVLMcil 324
Cdd:cd15314  154 GGCLVFFsKVSSVVGSVFSFYI----PAVIMLCIYLKIflvaqrqARSI--QSARTKSGASSSKMERKATKTLAIVM--- 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 325 TAYVLCWAPFygfaivrdFFPTVFVKEKHYLTAFYVVE---CIAMSNSMIN 372
Cdd:cd15314  225 GVFLLCWTPF--------FLCNIIDPFINYSIPPVLIEvlnWLGYSNSTLN 267
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
97-335 2.06e-13

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 69.95  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDT--WTLGYFICEIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMK--YQTATGLIALVWVVSILVAIPSAYFTTETVLVIvksqekifcgqi 254
Cdd:cd15335   79 VDMTCCTCSILHLCVIALDRYWAITDAIEYARKrtAKRAGLMILTVWTISIFISIPPLFWRNHHDANI------------ 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wPVDQQIYYKSYFLFIFGI--EFVGPVVTMTLCYARI----SRElwfkavpgfqteqirkrlrcrRKTVLVLMCILTAYV 328
Cdd:cd15335  147 -PSQCIIQHDHVIYTIYSTfgAFYIPLTLILILYYRIyhaaSRE---------------------RKAARILGLILGAFI 204

                 ....*..
gi 528968953 329 LCWAPFY 335
Cdd:cd15335  205 LSWLPFF 211
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
102-382 2.07e-13

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 70.19  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccPFEMDYYVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15209    6 VLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIY--PYPLILHAIFHNGWTLGQLHCQASGFIMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPSAYFTTetvlviVKSQEKIFCGQIwpvdQ 259
Cdd:cd15209   84 VIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCcyLCLTWLLTVLAVLPNFFIGS------LQYDPRIYSCTF----A 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelWFKAVpgfqteQIRKRLRCRRK---------TVLVLMCILTAYVLC 330
Cdd:cd15209  154 QTVSTVYTITVVVIHFLLPLLIVSFCYLRI----WVLVL------QVRQRVKPDQRpklkpadvrNFLTMFVVFVLFAVC 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 331 WAP--FYGFAIVRDFFPTV-FVKEKHYLTAFYvvecIAMSNSMINTVCFVTVKNN 382
Cdd:cd15209  224 WAPlnFIGLAVAINPKEMApKIPEWLFVASYF----MAYFNSCLNAIIYGLLNQN 274
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
112-335 2.13e-13

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 70.32  E-value: 2.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15377   16 LGNSVAIWMFVFHMKPWSGISVYMFNLALADFLY-VLTLPALIFYYF-NKTDWIFGDAMCKLQRFIFHVNLYGSILFLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSAYFTTETvlviVKSQEKIFCGQIWPVDqqiYYKSYFLF 269
Cdd:cd15377   94 ISVHRYTGVVHPLKSlgRLKKKNAICISVLVWLIVVVAISPILFYSGTG----VRKNKTITCYDTTSDE---YLRSYFIY 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528968953 270 -----IFGieFVGPVVTMTLCYARISRELWFKAVpgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15377  167 smcttVAM--FCVPFILILGCYGLIVRALIYKDM----KYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFH 231
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
129-389 2.20e-13

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 70.19  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 129 NLTNLLIANLAISDFLVAIVCCPFEMDyyVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-R 207
Cdd:cd15189   33 TVAEIYLGNLAAADLVFVSGLPFWAMN--ILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAArR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 208 MKYQTATGLIALV-WVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDQQIYYKSYFLFIFGieFVGPVVTMTLCY 286
Cdd:cd15189  111 LRRRRYAKLICVLiWVVGLLLSIPTFLLRK---IKAIPDLNITACVLLYPHEAWHFAHIVLLNIVG--FLLPLLVITFCN 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 287 ARISRELwfkavpGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECI-- 364
Cdd:cd15189  186 YNILQAL------RTREESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDECFWEHFIDIGLQLav 259
                        250       260
                 ....*....|....*....|....*..
gi 528968953 365 --AMSNSMINTVCFVTVKNntikYFKK 389
Cdd:cd15189  260 flAFSNSCLNPVLYVFVGR----YFRR 282
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
112-379 2.23e-13

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 70.27  E-value: 2.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPfeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15976   16 IGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIP--INVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPR---MKYQTATGlIALVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCgQIWPVDQ----QIYYK 264
Cdd:cd15976   94 LSIDRYRAVASWSRIKgigVPKWTAVE-IVLIWVVSIILAVPEA-IGFDMITMDYKGELLRIC-LLHPIQKtafmQFYKT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLFIFGIEFVGPVVTMTLCYARISRELwFKAVPGFQTeQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFAIV-RDF 343
Cdd:cd15976  171 AKDWWLFSFYFCLPLACTAVFYTLMTCEM-LRKKNGMQI-ALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILkLTI 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 528968953 344 FPTVFVKEKHYLTAFYVVECIAMS----NSMINTVCFVTV 379
Cdd:cd15976  249 YDEKDPNRCELLSFFLVLDYIGINmaslNSCINPIALYLV 288
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
106-335 2.74e-13

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 69.85  E-value: 2.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpfemdYYVVRQLSWE-----HG-HVLCASVNYLRT 179
Cdd:cd15387   10 ILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAV--------FQVLPQLIWDitfrfYGpDFLCRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAlVWVVSILVAIPSAY-FTTETVLVIVKSQEKIFCgQIWPVd 258
Cdd:cd15387   82 VGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF-SWLLSLVFSIPQVHiFSLREVGNGVYDCWADFI-QPWGP- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 qqiyyKSYFLFIFGIEFVGPVVTMTLCYARISRELW-------FKAVPGFQTEQIRKRLRCRR------------KTVLV 319
Cdd:cd15387  159 -----KAYITWITLSVYIIPVLILSVCYGLISFKIWqnvklktRRETKTPLSSAASGGAALARvssvkliskakiRTVKM 233
                        250
                 ....*....|....*.
gi 528968953 320 LMCILTAYVLCWAPFY 335
Cdd:cd15387  234 TFVIVLAYIVCWTPFF 249
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
97-376 3.46e-13

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 69.17  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNY 176
Cdd:cd15327    1 VGVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLG--FWAFGRVFCDIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTETVlvivkSQEKIFCGqi 254
Cdd:cd15327   79 VDVLCCTASILSLCVISVDRYVGVKHSLKypTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPP-----PPDESICS-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wpVDQQiyyKSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAVPGFQTEqirkrlrcrRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15327  152 --ITEE---PGYALFSSLFSFYLPLMVILVMYFRV-----YVVALKFSRE---------KKAAKTLAIVVGVFILCWFPF 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528968953 335 YGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15327  213 FFVLPLGSFFPALKPSE----MVFKVIFWLGYFNSCVNPIIY 250
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
99-376 4.64e-13

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 69.08  E-value: 4.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIML--VCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFeMDYYVVRQlSWEHGHVLCASVNY 176
Cdd:cd15301    1 VLIVIVAAVLslVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPL-FTVYTALG-YWPLGYEVCDTWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYfttetvlvivkSQEKIFCGQI 254
Cdd:cd15301   79 IDYLASNASVLNLLIISFDRYFSVTRPLtyRARRTTKKAAVMIASAWIISLLLWPPWIY-----------SWPYIEGKRT 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVD----QQIYYKSYFLFIFGI-EFVGPVVTMTLCYARISRElwfkavpgfqTEQIRKrlRCRRKTVLVLMCILTAYVL 329
Cdd:cd15301  148 VPAGtcyiQFLETNPYVTFGTALaAFYVPVTIMCILYWRIWRE----------TKKRQK--KQESKAAKTLSAILLAFIV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIamsNSMINTVCF 376
Cdd:cd15301  216 TWTPYNVLVLIKAFFPCSDTIPTELWDFSYYLCYI---NSTINPLCY 259
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
103-334 5.78e-13

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 69.02  E-value: 5.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLvCGIGNFIFIaalaRYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSL 182
Cdd:cd15154   12 PVGLLL-NAVALWVFV----RYLRLHSVVSIYMCNLALSDLLFTL-SLPLRIYYYANHY--WPFGNFLCQFSGSIFQMNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETvLVIVKSQEKIFCGQIWPVDQQ 260
Cdd:cd15154   84 YGSCLFLMCINVDRYLAIVHPLRFRhlRRPKVARLLCLAVWALILGGSVPAAIVHSSS-DCLLHGEKVYRCFESFSDNDW 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 261 IYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIrKRLRcRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15154  163 KGLLPLVVLAEILGFLLPLAAVLYCSCRIFVEL-------CRTQEP-QQGR-RRKTVRLLLVNLVIFLICFVPY 227
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
99-340 7.42e-13

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 68.74  E-value: 7.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGI--GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15957    1 VGMGIVMSLIVLAIvfGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKT--WTFGNFWCEFWTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLrprmKYQT------ATGLIALVWVVSILvaipSAYFTTETVLVIVKSQEKIF 250
Cdd:cd15957   79 IDVLCVTASIETLCVIAVDRYFAITSPF----KYQSlltknkARVIILMVWIVSGL----TSFLPIQMHWYRATHQEAIN 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRE------------------LWFKAVPGFQTEQIRKRLRC 312
Cdd:cd15957  151 CYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEakrqlqkidksegrfhnqNIDQNGSGGGGGNRRRSKFC 230
                        250       260       270
                 ....*....|....*....|....*....|
gi 528968953 313 RR--KTVLVLMCILTAYVLCWAPFYGFAIV 340
Cdd:cd15957  231 LKehKALKTLGIIMGTFTLCWLPFFIVNIV 260
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
129-335 7.83e-13

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 68.63  E-value: 7.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 129 NLTNLLIANLAISDFLVaIVCCPFeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR- 207
Cdd:cd15373   33 NASTTYMFNLAISDTLY-VLSLPL-LVYYYADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLr 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 208 -MKYQTATGLIALVWVVSILVAIPSAYFTT-----ETVLVIVKSQEKIFcgqiwpvDQQIYYKSYFLFIFgieFVGPVVT 281
Cdd:cd15373  111 wLKVRYARIVSVVVWVIVLACQSPVLYFVTtsdkgGNITCHDTSSPELF-------DQFVVYSSVMLVLL---FCVPFVV 180
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 282 MTLCYARISRELWFKAVPGFQTEqirkrlRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15373  181 ILVCYALMVRKLLKPSAGTSTNS------RSKKKSVKMIIIVLAVFILCFLPFH 228
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
97-376 7.93e-13

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 68.00  E-value: 7.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGY--WVFGRIFCDIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVAIPSAYFTTETVlvivkSQEKIFCgqi 254
Cdd:cd15326   79 VDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALlgVWVLSTVISIGPLLGWKEPA-----PPDDKVC--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 wPVDQQIYYKsyfLFIFGIEFVGPVVTMTLCYARIsrelwFKAVPGFQTEqirkrlrcrRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15326  151 -EITEEPFYA---LFSSLGSFYIPLIVILVMYCRV-----YIVALKFSRE---------KKAAKTLGIVVGMFILCWLPF 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528968953 335 YGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15326  213 FIALPLGSLFSHLKPPE----TLFKIIFWLGYFNSCLNPIIY 250
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
108-376 8.27e-13

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 68.36  E-value: 8.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIG---NFiFIAALARYKKLRNLT--NLLIANLAISDFLVAIVccpfeMDYYVVRQL---SWEHGHVLCASVNYLRT 179
Cdd:cd15925    9 LVCAIGllgNL-AVMYLLRNCARRAPPpiDVFVFNLALADFGFALT-----LPFWAVESAldfHWPFGGAMCKMVLTATV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTETVLVIVKsqekiFCGQIWPV 257
Cdd:cd15925   83 LNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTfwAKIITLALWAAALLATVPTAIFATEGEVCGVE-----LCLLKFPS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 258 DQqiYYKSYFLFIFGIEFVGPVVTMTLCYARIsreLWFKAVPGFQTEQIRKRLRCRRKTVLVLMciltAYVLCWAP---- 333
Cdd:cd15925  158 NY--WLGAYHLQRVVVAFVVPLGVITTSYLLL---LSFLQQHKVNQNNRQRQSVIARSVRLVVA----SFFLCWFPnhvv 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 334 -FYGFAIVRDFFP--TVFVKEKHYLtaFYVVECIAMSNSMINTVCF 376
Cdd:cd15925  229 tFWGVLVKFRAVPwnSTFYFIHTYV--FPVTTCLAHSNSCLNPVLY 272
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
94-335 1.21e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 67.94  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  94 AAKIVIGMalvgIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFemdyyVVRQLS---WEHGHVL 170
Cdd:cd15008    1 AASLVFGV----LWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPF-----VLLQFTsgrWTLGSAM 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 171 CASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETvlviVKSQEKIF 250
Cdd:cd15008   72 CKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSN----WGPHCNFF 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWpvDQQIYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAVPGfqtEQIRKRL----RCRRKTVLVLMCILTA 326
Cdd:cd15008  148 LPDSW--DGAAYAIIHLLVGFLV----PSILIILFYQKVIKYIWRIGTDG---RTVRRTMnivpRTKVKTIKMFLMLNSM 218

                 ....*....
gi 528968953 327 YVLCWAPFY 335
Cdd:cd15008  219 FLLSWLPFY 227
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
121-337 1.25e-12

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 67.79  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 121 LARYKKLRNLtNLLIANLAISDFLVAIVCcPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAI 200
Cdd:cd15967   26 LANWKKLGNI-NVFVLNLGLADLLYLLTL-PFLVVYYL-KGRKWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 201 VHPLRPRMKYQTATGLI--ALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFcgqiwPVDQQIYYKSYFLFIFGIEFVG- 277
Cdd:cd15967  103 VHPMRVMGRITTTHSVVisALVWLLVVIQSLPDLFFSK-----TNSNGTKCF-----DTTFNDYLESYLTYSLGWTVTGf 172
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528968953 278 --PVVTMTLCYARIsrelwfkAVPGFQTEQIRKRLRCRrktVLVLMCILTA-YVLCWAPFYGF 337
Cdd:cd15967  173 viPLLIILGCYGHV-------VVVLCRNNNVDKGLKQR---CLKLVIILIVlFSVCYIPYHVF 225
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
106-334 1.33e-12

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 67.52  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMdYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15187   10 LFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASD-LLFVFSLPFQA-YYLLDQ--WVFGNAMCKIVSGAYYIGFYSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPrMKYQTA---TGLIALVWVVSILVAIPSAYFTTEtvlviVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd15187   86 MFFITLMSIDRYLAIVHAVYA-LKVRTAshgTILSLALWLVAILASVPLLVFYQV-----ASEDGRLQCIPFYPGQGNSW 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 263 --YKSYFLFIFGIEFvgPVVTMTLCYARISRELWfkavpgfqteqiRKRLRCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15187  160 kvFTNFEVNILGLLI--PFSILIFCYHNILRNLR------------RCHNQNKTKAIKLVFIVVIVFFLFWTPF 219
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
103-389 1.39e-12

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 67.87  E-value: 1.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLvaIVCC-PFeMDYYVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15381    7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLL--LVCClPF-WAINISNGFNWPFGEFLCKSVNAVIYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLR-PRMKYQTATGLIALV-WVVSILVAIPSAYFTTetvlVIVKSQEKIF-CGQIWPVD 258
Cdd:cd15381   84 LYSSIYFLMMVSIDRYLALVKTMSsGRMRRPACAKLNCLIiWMFGLLMSTPMIVFRT----VMYFPEYNITaCVLDYPSE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 259 QQIYYKSYFLFIFGieFVGPVVTMTLCYARISRELWFKAVPGFQteQIRKRlrcRRKTVLVLMcILTAYVLCWAPFYGFA 338
Cdd:cd15381  160 GWHVALNILLNVVG--FLIPLSIITFCSTQIIQVLRNNKMQKFK--EIQTE---RKATVLVLA-VLLMFFICWLPFHIFT 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 339 IVRDFFPTVFVKEKHYLTAFYVVECI----AMSNSMINTVCFVTVKnntiKYFKK 389
Cdd:cd15381  232 FLDTLHKLGLISGCRWEDILDIGTQIatflAYSNSCLNPLLYVIVG----KHFRK 282
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
106-372 1.47e-12

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 67.49  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15368   10 VALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIQRN-HWIFGKPLCNVVTVLFYANMYSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPsayFTTETVLVIVKSQEKIFCGQI--WPVDQQI 261
Cdd:cd15368   88 ILTMTCISIERYLGVVYPMRSMRwrKKRYAVAACIGMWLLVLTALSP---LERTDLTYYVKELNITTCFDVlkWTMLPNI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 262 YYKSYFLF-IFGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLRCRRKTVLVLMcILTAYVLCWAP----FYG 336
Cdd:cd15368  165 AAWAAFLFtLFILLFLIPFIITVYCYVLIILKL-------VQTSERYGREQKRRAIYLALI-VLLVFITCFAPnnfiLLA 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528968953 337 FAIVRDFFptvfvkEKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15368  237 HMVSRLFY------GKSLYHAYKLTLSLSCLNSCLD 266
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
103-335 1.68e-12

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 67.24  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSL 182
Cdd:cd15305    8 LIIIILTIG-GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSL-IAILYDYAWPLPRYLCPIWISLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLR-PRMKYQTATGL-IALVWVVSILVAIPsayfttetVLVI-VKSQEKIFCGQIWPVDQ 259
Cdd:cd15305   86 TASIMHLCAISLDRYVAIRNPIEhSRFNSRTKAMMkIAAVWTISIGISMP--------IPVIgLQDDEKVFVNGTCVLND 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 260 QiyykSYFLFIFGIEFVGPVVTMTLCYARIsrelwfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15305  158 E----NFVLIGSFVAFFIPLIIMVITYCLT-----------IQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFF 218
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
103-344 2.10e-12

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 67.38  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdyyvVRQLS--WEHGHVLCAsVNY---- 176
Cdd:cd15312    7 MAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSM----VRSVEscWYFGDLFCK-IHSsldm 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 -LRTVSLYvstnALLAIAIDRYLAIVHPLRPRMKYQTAT--GLIALVWVVSILVAIpSAYFTTETVLVIVKSQEKIFCGQ 253
Cdd:cd15312   82 mLSTTSIF----HLCFIAVDRYYAVCDPLHYRTKITTPVikVFLVISWSVPCLFAF-GVVFSEVNLEGIEDYVALVSCTG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVdqqIYYKSYFLFIFGIEFVGPVVTMTLCY----------ARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCI 323
Cdd:cd15312  157 SCVL---IFNKLWGVIASLIAFFIPGTVMIGIYikiffvarkhAKVINNRPSVTKGDSKNKLSKKKERKAAKTLSIVMGV 233
                        250       260
                 ....*....|....*....|.
gi 528968953 324 ltaYVLCWAPFYgFAIVRDFF 344
Cdd:cd15312  234 ---FLLCWLPFF-VATLIDPF 250
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
101-365 2.49e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 67.19  E-value: 2.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALV--GIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLR 178
Cdd:cd15357    3 MSLVyaVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEV-YEMWSNYPFLFGPVGCYFKTALF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSLYVSTNALLAIAIDRYLAIVHPLRPRMK--YQTATGLIALVWVVSILVAIPSA--------YFTTETvlVIVKSQEK 248
Cdd:cd15357   82 ETVCFASILSVTTVSVERYVAILHPFRAKLNstRERALKIIVVLWVLSVLFSIPNTsihgiklqYFPNGT--LIPDSATC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IFCGQIWPVDQQIYYKSYFLFIFgiefvgPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLR--CRRKTVLVLMCILTA 326
Cdd:cd15357  160 TVVKPLWIYNLIIQITSLLFYVL------PMGVISVLYYLMGLKL--RGDKSLEADEMNVNIQrpSRKSVTKMLFVLVLV 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528968953 327 YVLCWAPFYgfaIVRDFFPTVFVKEKHYLTAFYVVECIA 365
Cdd:cd15357  232 FAICWAPFH---VDRLFFSFVVEWTEPLANVFNLIHVVS 267
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
103-387 2.60e-12

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 66.68  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEmdYYVVRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15086    6 FLGFILTFGfLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFS--FAASTQGRWLIGEHGCRWYGFANSLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRM-KYQTATGLIALVWVVSILVAIP-----SAY-----FTTETVLVIVKSQEKIf 250
Cdd:cd15086   84 GIVSLISLAVLSYERYCTLLRPTEADVsDYRKAWLGVGGSWLYSLLWTLPpllgwSSYgpegpGTTCSVQWTSRSANSI- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 cgqiwpvdqqiyykSYFLFIFGIEFVGPVVTMTLCYARISreLWFKAVPGFQTEQIRKRlrcRRKTVLVLMCILTAYVLC 330
Cdd:cd15086  163 --------------SYIICLFIFCLLLPFLVMVYCYGRLL--YAIKQVGKINKSTARKR---EQHVLLMVVTMVICYLLC 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 331 WAPFYGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15086  224 WLPYGVMALLATFGKPGLVTP----VASIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
126-376 3.05e-12

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 66.87  E-value: 3.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 126 KLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR 205
Cdd:cd15155   30 KMRNETAIFMTNLAVSD-LLFVFTLPFKIFYNFNRH--WPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 206 PRM--KYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWpvdqQIYYKSYFLFIFGIEFVGPVVTMT 283
Cdd:cd15155  107 SRTirTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIW----KTYLSKITIFIEVVGFIIPLLLNL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 284 LCYARISRELWFKAVPGFQTEQIRKRLrcrrKTVLVLMCIltaYVLCWAPF----YGFAIVRDFFPTVFVKEKHYLTAFY 359
Cdd:cd15155  183 TCSSLVLRTLRKPATLSQIGTNKEKVL----KMILVHVAI---FVVCFVPYnsilFLYALVRSQAIANCGVERFARTMYP 255
                        250
                 ....*....|....*..
gi 528968953 360 VVECIAMSNSMINTVCF 376
Cdd:cd15155  256 ITLCLATLNCCFDPFVY 272
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-387 3.25e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 66.51  E-value: 3.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLL---IANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCAS 173
Cdd:cd15130    1 VLVTAIYLALFVVGtVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPsayfttetVLVIVKSQEKIFC 251
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIP--------MLFTMGLQNESDD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQ------IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLcyarisrelwfkavpgFQTEQIRKRLRCRRKTVLVLMCILT 325
Cdd:cd15130  153 GThpgglvCTPIVDTATLKVVIQVNTFMSFLFPMLVTSI----------------LNTVIANKLVQALRRGVLVLRAVVI 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 326 AYVLCWAPFYG----FAIVRDFFPTVFVKE-KHYLtaFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15130  217 AFVVCWLPYHVrrlmFCYISDEQWTTFLFDfYHYF--YMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
114-335 3.81e-12

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 66.34  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVRQLsWEHGHVLCASVNYLRTVSLYVSTNALLAIA 193
Cdd:cd15968   18 NSVVLTRCCRHTKAWTRTAIYMVNLALADLLYAL-SLPLLIYNYAMRDR-WLFGDFMCRLVRFLFYFNLYGSILFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPLRPrMKYQT---ATGLIALVWVVSILVAIPSAYFTTETVLVivksqEKIFCGQIWPVDQQIYYKSYFLFI 270
Cdd:cd15968   96 VHRYLGICHPMRP-WHKETrraAWLTCVLVWILVFAQTLPILIFARTGIIR-----NRTVCYDLAPPALFPHYVPYGMAL 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 271 FGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRkrlrcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15968  170 TVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQAR-----RRKSIRTIVTVTLLFALCFLPFH 229
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
98-376 3.82e-12

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 66.47  E-value: 3.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYL 177
Cdd:cd15959    2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGH--WPLGTTVCELWTSV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVA---IPSAYFTTETVLVIVKSQEKIFCG 252
Cdd:cd15959   80 DVLCVTASIETLCAIAVDRYLAITNPLRYEAlvTKRRARTAVCLVWAISAAISflpIMNQWWRDGADEEAQRCYDNPRCC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIwpvdqqIYYKSYFLFIFGIEFVGPVVTMTLCYARI----SRELWFKA-----VPGFQTEQIRKRLRCRR--------- 314
Cdd:cd15959  160 DF------VTNMPYAIVSSTVSFYVPLLVMIFVYVRVfvvaTRQVRLIRkdkvrFPPEESPPAESRPACGRrpsrllaik 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 315 --KTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTvFVKEKhyltAFYVVECIAMSNSMINTVCF 376
Cdd:cd15959  234 ehKALKTLGIIMGTFTLCWLPFFVANIIKVFCRS-LVPDP----AFLFLNWLGYANSAFNPIIY 292
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
106-335 4.23e-12

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 66.43  E-value: 4.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLL---IANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSL 182
Cdd:cd15356   10 IWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFVWFHYPWVFGDLVCRGYYFVRDICS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVdqQ 260
Cdd:cd15356   90 YATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWASSLGFALPMAFIMGQKYELETADGEPEPSSRVCTV--L 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 261 IYYKSYFLFIFGIEFVGPVVTMTLCyarisrelwfkAVPGFQTEQiRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15356  168 VSRATLKVFIQVNAFVSFVLPLALI-----------AFLNGVTVS-HLRIQSLQHSVQVLRAIVIAYVICWLPYH 230
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
102-376 4.25e-12

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 66.14  E-value: 4.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIM-----LVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNY 176
Cdd:cd17790    1 VLIVITtgilsLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGH--WALGTVACDLWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSAYFTTETVlvivkSQEKIFCGQI 254
Cdd:cd17790   79 LDYVASNASVMNLLIISFDRYFSITRPLTYRAKRtpRRAAIMIGLAWLISFVLWAPAILFWQYLV-----GERTVLAGQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WpvdqqIYYKSYFLFIFGI---EFVGPVVTMTLCYARISRelwfkavpgfqtEQIRKrlrcrRKTVLVLMCILTAYVLCW 331
Cdd:cd17790  154 Y-----IQFLSQPIITFGTaiaAFYLPVTIMIILYWRIYR------------ETIKE-----KKAARTLSAILLAFILTW 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 332 APFYGFAIVRDFFPTVfVKEKHYLTAFYvvecIAMSNSMINTVCF 376
Cdd:cd17790  212 TPYNIMVLVSTFCKDC-VPKTLWELGYW----LCYVNSTVNPMCY 251
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
102-334 4.33e-12

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 66.25  E-value: 4.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFemdYYVVRQLSWEHGHVLCASVNYLRTV 180
Cdd:cd15180    5 VLYSLVFLLGlLGNGLVLAVLLQKRRNLSVTDTFILHLALADILL-LVTLPF---WAVQAVHGWIFGTGLCKLAGAVFKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHP--LRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVlviVKSQEKIFCGQIWPVD 258
Cdd:cd15180   81 NFYCGIFLLACISFDRYLSIVHAvqMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATK---DPRQNKTECVHNFPQS 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953 259 QQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLRCRRktvlVLMCILTAYVLCWAPF 334
Cdd:cd15180  158 DTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRL-------LRSSQGFQKQRAIR----VIVAVVVVFFLCWTPY 222
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
102-335 5.47e-12

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 65.73  E-value: 5.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTV 180
Cdd:cd15323    5 AVVGFLIVFTIvGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGY--WYFGQVWCNIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIP---SAYFTTEtvlvivksqekifcGQIW 255
Cdd:cd15323   83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRtpRRVKAIIVTVWLISAVISFPpliSMYRDPE--------------GDVY 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 PVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelwfkavpgFQTEQIRKrlrcrRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15323  149 PQCKLNDETWYILSSCIGSFFAPCLIMILVYIRI-----------YRVAKARE-----KRFTFVLAVVMGVFVVCWFPFF 212
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
137-341 7.28e-12

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 65.57  E-value: 7.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 137 NLAISDFLVaIVCCPFEMDYyVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTAT 214
Cdd:cd15365   41 NLSLSDLLY-IVILPLWIDY-LWNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHlrTIRTAL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 215 GLIALVWVVSILVaipSAYFTTETVLVIVKSQEKIfCGQIWPVDQqiYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelw 294
Cdd:cd15365  119 SVSVAIWLLEICF---NAVILTWEDSFHESSSHTL-CYDKFPLED--WQARLNLFRICLGYLLPLLIILFCYWKI----- 187
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 295 FKAVPGFQTEQIRKRLRCRRKTVLVLMCiltaYVLCWAPFYGFAIVR 341
Cdd:cd15365  188 YQAVRSNQATEDQEKKKIFKLLLLITVT----FVICFTPYHVVLLIR 230
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
112-382 7.82e-12

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 65.26  E-value: 7.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15400   16 LGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALY--PYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPSAYFTTetvlviVKSQEKIF-CGQIwpvdqQIYYKSYFL 268
Cdd:cd15400   94 IAINRYCYICHSFAYDKLYSRWNTLlyVCLIWALTVVAIVPNFFVGS------LEYDPRIYsCTFV-----QTASSSYTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 269 FIFGIEFVGPVVTMTLCYARIsrelWFKAVPGFQTEQIRKRLRCRR---KTVLVLMCILTAYVLCWAPFYGFAIVRDFFP 345
Cdd:cd15400  163 AVVVIHFIVPITVVSFCYLRI----WVLVIQVRRKVKSESKPRLKPsdfRNFLTMFVVFVIFAICWAPLNLIGLAVAINP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 528968953 346 TVF---VKEKHYLTAFYvvecIAMSNSMINTVCFVTVKNN 382
Cdd:cd15400  239 QEMapkVPEWLFVVSYF----MAYFNSCLNAIIYGLLNQN 274
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
126-333 1.07e-11

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 64.81  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 126 KLRNLTNLLIANLAISDFLVAIvCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR 205
Cdd:cd15199   30 KVWKPYAVYLLNLVLADVLLLI-CLPFKAYFYLNGN-RWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 206 PR--MKYQTATGLIALVWVVSILVAIPsayfttetvlVIVKSQEKIF--CGQIWPVDQQIYYKSYFLFIFGIEFVGPVVT 281
Cdd:cd15199  108 KKnsLSLQAAPYISFLVWLLLVGLTIP----------TLLASQPKNFteCNSFSPKDDEDFSDTWQEAVFFLQFLLPFGL 177
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528968953 282 MTLCYARISRELWFKavpgfqTEQIRKRLRCRRKTVLVLMCILTaYVLCWAP 333
Cdd:cd15199  178 IVFCTVRIIRRLKKR------LRDVGKQPKLQRAMALVTSVVVV-FGFCFLP 222
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
114-339 1.09e-11

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 64.85  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVaiVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIA 193
Cdd:cd15077   18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIV--VCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSLAVVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPLrPRMKYQTATGLI--ALVWVVSILVAIPSAYFTTEtvlvIVKSQEKIFCGQIW-PVDQQIYYKSYFLFI 270
Cdd:cd15077   96 FERFLVICKPL-GNFTFRGTHAIIgcIATWVFGLAASLPPLFGWSR----YIPEGLQCSCGPDWyTTNNKWNNESYVMFL 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 271 FGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLmciLTAYVLCWAPFYGFAI 339
Cdd:cd15077  171 FCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKAEREVTKMVVVM---VLGFLVCWLPYASFAL 236
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
106-335 1.14e-11

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 65.31  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPfeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15977   10 IFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIP--INVIKLIAEDWPFGVHVCKLYPFIQKASVGIT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVH---------PLRPRMKyqtatglIALVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCgqIWP 256
Cdd:cd15977   88 VLSLCALSIDRYRAVASwsrirgigiPVWKAVE-------VTLIWAVAIIVAVPEA-IAFDMVEIDYRGQTLLVC--MLP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQIYYKSYF-----LFIFGIEFVGPVVTMTLCYARISRELWFKAvPGFQTeQIRKRLRCRRKTVLVLMCILTAYVLCW 331
Cdd:cd15977  158 MEQTSSFMRFYqdvkdWWLFGFYFCLPLACTGVFYTLMSCEMLSIK-NGMRI-ALNDHMKQRREVAKTVFCLVVIFALCW 235

                 ....
gi 528968953 332 APFY 335
Cdd:cd15977  236 LPLH 239
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
106-378 1.14e-11

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 64.61  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15310   10 LILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVV-YLEVTGGVWNFSRICCDVFVTLDVMMCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRprmkYQTATG---------LIALVWVVSILVAIPSAY-FTTETVLVIVKSQEKIFcgqiw 255
Cdd:cd15310   89 ILNLCAISIDRYTAVVMPVH----YQHGTGqsscrrvslMITAVWVLAFAVSCPLLFgFNTTGDPTVCSISNPDF----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 pvdqqIYYKSYflfifgIEFVGPVVTMTLCYARISRELwfkavpgfqteqirkrLRcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15310  160 -----VIYSSV------VSFYLPFGVTLLVYVRIYVVL----------------LR-EKKATQMLAIVLGAFIVCWLPFF 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 528968953 336 GFAIVRDFFPTVFVKEKHYLTAFYvvecIAMSNSMINTVCFVT 378
Cdd:cd15310  212 LTHILNTHCQACHVPPELYSATTW----LGYVNSALNPVIYTT 250
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
106-290 1.25e-11

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 64.81  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARY-KKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRqlsWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15188   10 VFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLF-LVTLPFWAMYVAWH---WVFGSFLCKFVSTLYTINFYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVH---PLRPRMKYQTATgLIALVWVVSILVAIPSAYFTTETVL---VIVKSQEKIFCGQIWpvd 258
Cdd:cd15188   86 GIFFVSCMSLDKYLEIVHaqsPHRLRTRRKSLL-VLVAVWVLSIALSVPDMVFVQTHHTnngVWVCHADYGGHHTIW--- 161
                        170       180       190
                 ....*....|....*....|....*....|...
gi 528968953 259 qqiyyKSYFLFIFGI-EFVGPVVTMTLCYARIS 290
Cdd:cd15188  162 -----KLVFQFQQNLlGFLFPLLAMVFFYSRIA 189
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
97-376 1.40e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 64.38  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFeMDYYVVRQLSWEHGHVLC---AS 173
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPF-YTVYVLNGDYWPLGWVLCdlwLS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYlrTVSLyVSTNALLAIAIDRYLAIVHPLRPRmKYQTATG---LIALVWVVSILVAIPS----AYFTTETvlVIVKSQ 246
Cdd:cd15302   80 VDY--TVCL-VSIYTVLLITIDRYCSVKIPAKYR-NWRTPRKvllIIAITWIIPALLFFISifgwQYFTGQG--RSLPEG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 247 EKIFCGQIWPVDQQIYYKSYFLFIfgiefvgpVVTMTLCYARISRelwfkavpgfQTEQIRKRLRcrrktvlVLMCILTA 326
Cdd:cd15302  154 ECYVQFMTDPYFNMGMYIGYYWTT--------LIVMLILYAGIYR----------AANRARKALR-------TITFILGA 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 327 YVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVeCIAmsNSMINTVCF 376
Cdd:cd15302  209 FVICWTPYHILATIYGFCEAPPCVNETLYTISYYL-CYM--NSPINPFCY 255
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
100-376 1.46e-11

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 64.41  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCG---IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15102    1 GATSVVFVAICCfivLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAA-------YLANILLSGARTLRLSPAQWF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYV----STNALLAIAIDRYLAIVHP-LRPRMKYQTATGLIALVWVVSILV-AIPSAYFTTETVLVIvksqekif 250
Cdd:cd15102   74 LREGSMFValsaSVFSLLAIAIERHLTMAKMkPYGASKTSRVLLLIGACWLISLLLgGLPILGWNCLGALDA-------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPvdqqIYYKSYFLFIFGIeFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRlRCRR--KTVLVlmcILTAYV 328
Cdd:cd15102  146 CSTVLP----LYSKHYVLFCVTI-FAGILAAIVALYARIYCLV--RASGRKATRASASP-RSLAllKTVLI---VLLVFI 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 329 LCWAPFYGFAIVRDFFPtvfVKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15102  215 ACWGPLFILLLLDVACP---VKTCPILYKADWFLALAVLNSALNPIIY 259
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
106-335 1.81e-11

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 64.46  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPfeMDYYVVRQLSWEHGH-----VLCASVNYLRTV 180
Cdd:cd15128   10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLP--INVYKLLAMDWPFGDqpfgqFLCKLVPFIQKA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPR---MKYQTATGlIALVWVVSILVAIPSAY--------FTTETVLVIVKSQEKI 249
Cdd:cd15128   88 SVGITVLNLCALSVDRYRAVASWSRIQgigIPMWTAVE-IVMIWMLSAVLAVPEAIgfdmvrfnYKGVTLRTCLLRPETS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 FcgqiwpvdQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAvPGFQTEQIRKRLRCRRKTVLVLMCILTAYVL 329
Cdd:cd15128  167 F--------MKFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKR-NGMLRIALNEHLKQRREVAKTVFCLVVIFAL 237

                 ....*.
gi 528968953 330 CWAPFY 335
Cdd:cd15128  238 CWLPLH 243
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
98-377 2.27e-11

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 64.01  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI---GNFIFIAALaRYKKLRNLTNLLiaNLAISDFLVAIVCcPFEMDYYVVRqLSWEHGHVLCASV 174
Cdd:cd15116    1 ILSMVIYSVVFVLGVlgnGLVIFITGF-KMKKTVNTVWFL--NLAVADFLFTFFL-PFSIAYTAMD-FHWPFGRFMCKLN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPL------RPRMkyqtATGLIALVWVVSILVAIPSAYFTTETVLvivKSQEK 248
Cdd:cd15116   76 SFLLFLNMFTSVFLLTVISIDRCISVVFPVwsqnhrSVRL----ASLVSLAVWVVAFFLSSPSFIFRDTAPS---QNNNK 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IFC---------GQIWPVDQQIY--YKSYFLFIFGIEFVGPVVTMTLCYARISRELWfkavpgfqteqiRKRLRCRRKTV 317
Cdd:cd15116  149 IICfnnfslsgdNSSPEVNQLRNmrHQVMTITRFLLGFLIPFTIIICCYAAIVLKLK------------RNRLAKSSKPF 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528968953 318 LVLMCILTAYVLCWAPFYGFAIV---RDFFPTVFVKEKHYLTAfyvveCIAMSNSMINTVCFV 377
Cdd:cd15116  217 KIIAAVIVTFFLCWAPYHILNLLemeATRSPASVFKIGLPITS-----SLAFINSCLNPILYV 274
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
106-374 2.69e-11

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 63.42  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15322   10 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY--WYFGKVWCEIYLALDVLFCTSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPSayfttetvLVIVKSQEKIFCGQIWPVDQQiyy 263
Cdd:cd15322   88 IVHLCAISLDRYWSITQAIEYNLKRtpRRIKCIIFIVWVISAVISFPP--------LITIEKKSGQPEGPICKINDE--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIEFVGPVVTMTLCYARIsrelwfkavpgFQTEQIRKrlrcrRKTVLVLMCILTAYVLCWAPFYgFAIVRDF 343
Cdd:cd15322  157 KWYIISSCIGSFFAPCLIMVLVYIRI-----------YQIAKNRE-----KRFTFVLAVVIGVFVICWFPFF-FTYTLTA 219
                        250       260       270
                 ....*....|....*....|....*....|.
gi 528968953 344 FPTVFVKEKHYLTAFYVVECIAMSNSMINTV 374
Cdd:cd15322  220 VCDCSVPETLFKFFFWFGYCNSSLNPVIYTI 250
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
98-335 2.82e-11

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 63.67  E-value: 2.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALA--RYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRqlSWEHGHVLCASV 174
Cdd:cd15122    1 ATGTIFLLLAALLGLpGNGFIIWSILwkMKARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRK--TWPFGQAVCKAV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHP-LRPRM-KYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCG 252
Cdd:cd15122   78 YYLCCLSMYASIFIIGLMSLDRCLAVTRPyLAQSLrKKALVRKILLAIWLLALLLALPAFVYRH---VWKDEGMNDRICE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQQIYYksYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRLRCRRktvlVLMCILTAYVLCWA 332
Cdd:cd15122  155 PCHASRGHAIF--HYTFETLVAFVLPFGVILFSYSVILVRL--------KGARFRRRARVEK----LIAAIVVAFALLWV 220

                 ...
gi 528968953 333 PFY 335
Cdd:cd15122  221 PYH 223
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
97-377 3.91e-11

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 63.25  E-value: 3.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALaryKKLRNLTNLLIANLAISDFLvaivCC---PFEMdYYVVRQLSWEHGHVLCAS 173
Cdd:cd15115    3 SLVVLSLTFLLGVPGNGLVIWVAGL---KMKRTVNTIWFLNLAVADLL----CClslPFSI-AHLLLNGHWPYGRFLCKL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFC 251
Cdd:cd15115   75 LPSIIVLNMFASVFTLTAISLDRFLLVIKPVwaQNHRSVLLACLLCGCIWILALLLCLPVFIYRT-----TVTDGNHTRC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIWPVDQQIYYksyflFIFGieFVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRLRCRRKTVLVlmcILTAYVLCW 331
Cdd:cd15115  150 GYDFLVAITITR-----AVFG--FLLPLLIIAACYSFIAFRM--------QRGRFAKSQSKTFRVIIA---VVVAFFVCW 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 332 APFYGFAIVRDFfpTVFVKEKHYLTAFYVVECIAMSNSMINTVCFV 377
Cdd:cd15115  212 APYHIIGILSLY--GDPPLSKVLMSWDHLSIALAYANSCLNPVLYV 255
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
132-336 4.77e-11

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 63.19  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 132 NLLIANLAISDFLvaIVCC-PFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKY 210
Cdd:cd15157   36 NIFMLNLAVSDLM--FVSTlPFRADYYL-MGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFK-LWKV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 211 QTATGLIALVWVVSILVAIPSAYFTTETVLVIvKSQEKifCGQIWP-VDQQIYYKSYFLFIFGieFVGPVVTMTLCYARI 289
Cdd:cd15157  112 TSIKYARILCAVIWIFVMAASSPLLSKGTSKY-NSQTK--CLDLHPsKIDKLLILNYIVLVVG--FILPFCTLSICYILI 186
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 290 SRELWFKAVPGfqteqiRKRLRCRRKTVLVLMCILTAYVLCWAPFYG 336
Cdd:cd15157  187 IKALLKPRVPQ------SKLRVSHKKALLTIIITLILFLLCFLPYHI 227
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
97-343 5.66e-11

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 62.55  E-value: 5.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdyYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFAL--VTIITTRWIFGDAFCRVSAM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPlRPRMKYQTATGLIALVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCGQIWP 256
Cdd:cd15404   79 FFWLFVMEGVAILLIISIDRFLIIVQK-QDKLNPYRAKVLIAVSWAVSFCVAFPLA-VGSPDLQIPSRAPQCVFGYTTNP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 vdqqiYYKSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAVPGFQTEQIrkrlrcrrKTVLVLMCIltaYVLCWAPFYG 336
Cdd:cd15404  157 -----GYQAYVILIMLIFFFIPFMVMLYSFMGI-----LNTVRSFKTRAF--------TTILILFIV---FTVCWAPFTT 215

                 ....*..
gi 528968953 337 FAIVRDF 343
Cdd:cd15404  216 YSLVATF 222
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
106-335 6.10e-11

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 62.84  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaiVCC-PFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15158   10 ITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLC--VCTlPLRVVYYV-HKGQWLFGDFLCRISSYALYVNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRpRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGqiwPVDQQIYYK 264
Cdd:cd15158   87 SIYFMTAMSFTRFLAIVFPVQ-NLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEP---PQSNQQLTK 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 265 ----SYFLFIFGieFVGPVVTMTLCYARISRELWFKavpgfqTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15158  163 llvlNYISLVVG--FIIPFLVILICYAMIIRTLLKN------TMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYH 229
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
131-333 6.69e-11

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493  Cd Length: 274  Bit Score: 62.51  E-value: 6.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 131 TNLLIANLAISDFLVAIVCcPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR-MK 209
Cdd:cd15371   34 TAIFYANLAISDLLFCITL-PFKIVYHLNGN-NWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRsLP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 210 YQTATGLI-ALVWVVSILVAIPsayfttetvLVIVKSQEKI------FCGQIWPVDQQIYYKSYFLFIFGI--EFVGPVV 280
Cdd:cd15371  112 KKTYAVLIcALVWTIVFLYMLP---------FFILKQTYYLkelnitTCHDVLPECEQNSNFQFYYFISMAvfGFLIPLV 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528968953 281 TMTLCYARISRELwfkavpgfqTEQIRKRLRCRRKTVLVLMciltAYVLCWAP 333
Cdd:cd15371  183 ITIFCYISIIRTL---------NAYEHKWFWYVKITALVLI----IFTICFAP 222
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
97-334 7.36e-11

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 62.57  E-value: 7.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNY 176
Cdd:cd15318    1 LVIYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSV--ESCWYFGDSFCRLHTC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWvvsilvAIPSAYfttETVLVIVKSQEKIFCGQI 254
Cdd:cd15318   79 LDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFtiRVACIFIAAGW------LVPTVY---TSVFLYTKAVEEGLAELL 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVD-----QQIYYKSYFLFIFGIEFVgPVVTMTLCYARISrelwfkAVPGFQTEQI-------RKRLRCRRKTVLVLMC 322
Cdd:cd15318  150 TSVPcvgscQLLYNKLWGWLNFPVFFI-PCLIMIGLYVKIF------IVAKRQARAIasllsdtNGASKRERKAAKTLGI 222
                        250
                 ....*....|..
gi 528968953 323 ILTAYVLCWAPF 334
Cdd:cd15318  223 AVGVYLLCWLPF 234
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
121-335 7.38e-11

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 62.41  E-value: 7.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 121 LARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAI 200
Cdd:cd15376   26 VTRERRPWHTGVVFSFNLAVSDLLYALSL-PLLAAYYYPPK-NWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 201 VHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFTTETvlviVKSQEKIFCGQIWPVDQQIYYKSYFLFIFGIEFVGP 278
Cdd:cd15376  104 VHPFftRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLE----VERHNKTECLGTAVDSRLPTYLPYSLFLAVVGCGLP 179
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 279 VVTMTLCYARISRELWfkAVPGFQTEQIRKrlrcrrktVLVLMCILTA-YVLCWAPFY 335
Cdd:cd15376  180 FLLTLASYLAIVWAVL--RSPGITTLEKRK--------VAALVAVVVAlYAVSFVPYH 227
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
98-340 1.14e-10

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 62.07  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALArYKKLRNLTNLLIANLAISDFlVAIVCCPFEMDYyVVRQLSWEHGHVLCASVNY 176
Cdd:cd15119    1 IVSIVIYIVAFVLGVpGNAIVIWVTG-FKWKKTVNTLWFLNLAIADF-VFVLFLPLHITY-VALDFHWPFGVWLCKINSF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPlRPRMKYQT---ATGLIALVWVVSILVAIPSAYFTTETVLvivkSQEKIFCGQ 253
Cdd:cd15119   78 VAVLNMFASVLFLTVISLDRYISLAHP-VWSHRYRTlksALILCGIVWLSAAAISGPALYFRDTMEL----SINVTICFN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 254 IWPVDQQ--IYYKSYFL----FIFGieFVGPVVTMTLCYARisreLWFKAVpgfqteqiRKRLRCRRKTVLVLMCILTAY 327
Cdd:cd15119  153 NFHKHDGdlIVMRHTILvwvrFFFG--FLFPLLTMVVCYSL----LAIKVK--------RRTLLISSKFFWTISAVIVAF 218
                        250
                 ....*....|...
gi 528968953 328 VLCWAPFYGFAIV 340
Cdd:cd15119  219 FVCWTPYHIFSIL 231
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
112-372 1.17e-10

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 61.77  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFeMDYYVVRQlsWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15186   16 VGNLLVVLALTNSGKSKSITDIYLLNLALSDLLF-VATLPF-WTHYLINE--WGLHNAMCKLTTAFFFIGFFGGIFFITV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIV---HPLRPRMKYQTATglIAL-VWVVSILVAIPSAYFTTETVLVIVKSQEKIFcGQIWPVdqqiyYKSYF 267
Cdd:cd15186   92 ISIDRYLAIVlaaNSMNNRTVQHGVT--ISLgVWAAAILVAVPQFMFTKMKENECLGDYPEVL-QEIWPV-----LRNVE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 268 LFIFGieFVGPVVTMTLCYARISRELWFKavpgfqteQIRKRLRCRRKTVLVLMciltAYVLCWAPFYGFAIVR-----D 342
Cdd:cd15186  164 LNFLG--FLLPLLIMSYCYFRIIQTLFSC--------KNHKKARAIKLILLVVI----VFFLFWTPYNVMIFLEtlklyD 229
                        250       260       270
                 ....*....|....*....|....*....|
gi 528968953 343 FFPTVFVKeKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15186  230 FFPSCDMK-KDLRLALSVTETIAFSHCCLN 258
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
104-235 1.18e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 61.83  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 104 VGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFL-------VAIVCCPFeMDYYVVRQLSWEHGHvLCASVNY 176
Cdd:cd15137   10 VGIIAL--LGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLmgvylliIASVDLYY-RGVYIKHDEEWRSSW-LCTFAGF 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVA----IPSAYFT 235
Cdd:cd15137   86 LATLSSEVSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLLAvlplLPWDYFG 149
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
113-335 1.33e-10

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 61.77  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLsWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAM-WPLPLVLCPIWLFLDVLFSTASIMHLCAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLRPRMKYQTATGL--IALVWVVSILVAIPSAYFTTETvlvivksqEKIFCGQIWPVDQQIYYKSYFLFI 270
Cdd:cd15306   96 SLDRYIAIKKPIQASQYNSRATAFikITVVWLISIGIAIPVPIKGIET--------DVDNPNNITCVLTKERFGDFILFG 167
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 271 FGIEFVGPVVTMTLCYarisrelwFKAVPGFQTEQIRKRLRCRRktvlVLMCILTAYVLCWAPFY 335
Cdd:cd15306  168 SLAAFFTPLAIMIVTY--------FLTIHALRKQTITNEQRASK----VLGIVFFLFLLMWCPFF 220
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
104-372 2.15e-10

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 61.11  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 104 VGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWeHGHVLCASVNYLRTVSly 183
Cdd:cd15068    8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC-HGCLFIACFVLVLTQS-- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 184 vSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCG--------- 252
Cdd:cd15068   85 -SIFSLLAIAIDRYIAIRIPLRynGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGegqvaclfe 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQQIYYKsyflfIFGIEFVgPVVTMTLCYARIS-------RELWFKAVPGfqtEQIRKRLRCRRKTVLVLMCILT 325
Cdd:cd15068  164 DVVPMNYMVYFN-----FFACVLV-PLLLMLGVYLRIFlaarrqlKQMESQPLPG---ERARSTLQKEVHAAKSLAIIVG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 326 AYVLCWAPFYgfaIVRDFfpTVFVK--EKHYLTAFYVVECIAMSNSMIN 372
Cdd:cd15068  235 LFALCWLPLH---IINCF--TFFCPdcSHAPLWLMYLAIVLSHTNSVVN 278
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
115-293 3.28e-10

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 60.64  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 115 FIFIAALarykKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAI 194
Cdd:cd15156   23 YIFMCTL----KVRNETTTYMINLAISDLLF-VFTLPFRIFYFVQR--NWPFGDLLCKISVTLFYTNMYGSILFLTCISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 195 DRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAYFTTETVLvivKSQEKIFCGQIWPVDQ-QIYYKSYFLFIF 271
Cdd:cd15156   96 DRFLAIVYPFRSKTlrTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQ---LNNNSETCFENFSSKTwKTYLSKIVIFIE 172
                        170       180
                 ....*....|....*....|..
gi 528968953 272 GIEFVGPVVTMTLCYARISREL 293
Cdd:cd15156  173 IVGFFIPLILNVTCSTMVLKTL 194
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
97-335 3.59e-10

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 60.74  E-value: 3.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLR-NLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGhvlcASVN 175
Cdd:cd15319    1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRsKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGY--WPFG----AFCD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALL---AIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVA-IPS--AYFTTETVLVIVKSQE 247
Cdd:cd15319   75 VWVAFDIMCSTASILnlcVISVDRYWAISSPFRyeRKMTQRVALVMISVAWTLSVLISfIPVqlNWHKDSGDDWVGLHNS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 248 KIFCGQIWPVDQQIyYKSYFLFIFGIEFVGPVVTMTLCYARISR--ELWFKAVPGFQT------------------EQIR 307
Cdd:cd15319  155 SISRQVEENCDSSL-NRTYAISSSLISFYIPVAIMIVTYTRIYRiaQIQIRRISSLERaaehaqscrsnridchhhTSLR 233
                        250       260
                 ....*....|....*....|....*...
gi 528968953 308 KRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15319  234 TSIKKETKVLKTLSVIMGVFVCCWLPFF 261
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
98-376 3.84e-10

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 60.19  E-value: 3.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCA---S 173
Cdd:cd15296    1 VILAVLMALLVVATVlGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGR--WKFGRGLCKlwlV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSlyvSTNALLAIAIDRYLAIVHPLRPRMK---YQTATGLIALVWVVSILVAIPSayfttetvlviVKSQEKIF 250
Cdd:cd15296   79 VDYLLCTA---SVFNIVLISYDRFLSVTRAVSYRAQkgmTRQAVLKMVLVWVLAFLLYGPA-----------IISWEYIA 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPVDQ---QIYYKSYFLFIFG-IEFVGPVVTMTlcyarisrelWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTA 326
Cdd:cd15296  145 GGSIIPEGEcyaEFFYNWYFLMTAStLEFFTPFISVT----------YFNLSIYLNIQKRRFRLSRDKKVAKSLAIIVCV 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 327 YVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVeciaMSNSMINTVCF 376
Cdd:cd15296  215 FGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLL----WVNSAINPVLY 260
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
97-387 4.05e-10

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 60.04  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpFEMDYYVVRQL--SWEHGHVLCASV 174
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGI----FSMNLYTSYILmgYWALGSLACDLW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY--QTATGLIALVWVVSILVAIPsayfttetvlVIVKSQEKIFCG 252
Cdd:cd15300   77 LALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRtpKRAGIMIGLAWLISFILWAP----------PILCWQYFVGKR 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPVDQQIYYKSYFLFIFGI---EFVGPVVTMTLCYARISRelwfkavpgfqtEQIRKrlrcrRKTVLVLMCILTAYVL 329
Cdd:cd15300  147 TVPERECQIQFLSEPTITFGTaiaAFYIPVSVMTILYCRIYK------------ETIKE-----RKAAQTLSAILLAFII 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 330 CWAPFYGFAIVrdffpTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTIKYF 387
Cdd:cd15300  210 TWTPYNIMVLV-----STFCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
101-334 4.11e-10

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 59.95  E-value: 4.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCasvNYLRTV 180
Cdd:cd15214    4 IAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRRE--WIFGVVWC---NFSALL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALL---AIAIDRYLAIVHPLRPRMKYQTATGLIALV--WVVSILVAIPSAYFTTETVLvivkSQEKIFCGQIW 255
Cdd:cd15214   79 YLLISSASMLtlgAIAIDRYYAVLYPMVYPMKITGNRAVLALVyiWLHSLIGCLPPLFGWSSLEF----DRFKWMCVAAW 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 256 pvDQQIYYKSYFLFIFGIEfvgPVVTMTLCYARISRelwfkavpgfqteqIRKRLRCrrKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15214  155 --HKEAGYTAFWQVWCALL---PFVVMLVCYGFIFR--------------VARANQC--KAFITILVVLGAFVTTWGPY 212
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
114-347 4.30e-10

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 60.20  E-value: 4.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIV--CCPFEMDYYVVRQLswehGHVLCA----SVNYLRTVSLYvstn 187
Cdd:cd15082   31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTggTISFLTNARGYFFL----GVWACVlegfAVTFFGIVALW---- 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 188 ALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAY-FTTETVLVIVKSqekifCGQIWpVDQQIYYKS 265
Cdd:cd15082  103 SLAVLAFERFFVICRPLGNiRLQGKHAALGLLFVWTFSFIWTIPPVLgWSSYTVSKIGTT-----CEPNW-YSGNMHDHT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 266 YFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRCRRKTVLVLMCILtAYVLCWAPFYGFAIVRDFFP 345
Cdd:cd15082  177 YIITFFTTCFILPLGVIFVSYGKLLQKL--RKVSNTQGRLGNARKPERQVTRMVVVMIV-AFMVCWTPYAAFSILVTAHP 253

                 ..
gi 528968953 346 TV 347
Cdd:cd15082  254 TI 255
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
98-374 5.02e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 60.06  E-value: 5.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCasvNYL 177
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDL--LGYWLFGETFC---NIW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVSTNALL---AIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYF------TTETVLVIVKSQ 246
Cdd:cd15065   76 ISFDVMCSTASILnlcAISLDRYIHIKKPLKyeRWMTTRRALVVIASVWILSALISFLPIHLgwhrlsQDEIKGLNHASN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 247 EKIFCG-QIWPVdqqiyyksYFLFIFGIEFVGPVVTMTLCYARI----------SRELWFKAVPGFQTEQIRKRLRCRR- 314
Cdd:cd15065  156 PKPSCAlDLNPT--------YAVVSSLISFYIPCLVMLLIYSRLylyarkhvvnIKSQKLPSESGSKFQVPSLSSKHNNq 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 315 -----KTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTVFVKEkhyltAFYVVECIAMSNSMINTV 374
Cdd:cd15065  228 gvsdhKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPK-----CFKILTWLGYFNSCLNPI 287
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
103-335 5.30e-10

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 59.75  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLvaIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSL 182
Cdd:cd14964    5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL--ASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFcgqiWPVdqQ 260
Cdd:cd14964   83 LASIWTTLVLTYHRYFALCGPLKYTrlSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYL----ICT--T 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 261 IYYKSYFLFIFgieFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTayVLCWAPFY 335
Cdd:cd14964  157 IYLTWGFLLVS---FLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITF--LLCWLPFS 226
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
106-335 5.35e-10

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 59.72  E-value: 5.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15161   10 VFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVAD-LSYVLILPMRLVYHL-SGNHWPFGEVPCRLAGFLFYLNMYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVsILVAIPSAYFTTETVLVivksQEKIFCGQIWpvdqqIYY 263
Cdd:cd15161   88 LYFLACISVDRFLAIVHPVKSMkiRKPLYAHVVCGFLWVI-VTVAMAPLLVSPQTVEV----NNTTVCLQLY-----REK 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528968953 264 KSYFLFI-FGIEFVGPVVTMTLCYARISRELwfkavpgFQTEQIRKRLrcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15161  158 ASRGALVsLAVAFTIPFVTTVTCYLLIIRSL-------RTGKREEKPL--KDKAIKMIILVLTIFLICFVPYH 221
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
91-374 5.98e-10

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 59.73  E-value: 5.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  91 TFFAAKIVIGMalvgimlvcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFlvaIVCCPFEMDYYVVRQLSWEHGHVL 170
Cdd:cd15378    5 TMYSIEFVLGF----------IGNTIVILGYIFCLKNWKSSNIYLFNLSVSDL---AFLCTLPMLVYSYSNGQWLFGDFL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 171 CASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAYFTtETVLVIVKSQEK 248
Cdd:cd15378   72 CKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHIlqKKRSAVAISLAIWVLVTLELLPILTFI-GPNLKDNVTKCK 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IFCGQIWPVDQQIYykSYFLFIFGieFVGPVVTMTLCYARISRELwfkavpGFQTEQIRKRLRCRRKTVLVLMCILTAYV 328
Cdd:cd15378  151 DYASSGDATNSLIY--SLFLTVTG--FLIPLCVMCFFYYKIALFL------KNRNRQLANATSFEKPLTLVILAVVIFSV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 329 LcWAPFYGFAIVRDFFPTVFVKEKH----YLTAFYVV-ECIAMSNSMINTV 374
Cdd:cd15378  221 L-FTPYHVMRNVRIASRLDSIGVSEctliIIKSLYIVtRPIAFLNSVINPV 270
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
97-347 6.21e-10

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 59.80  E-value: 6.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALaRYKKLRNLTNLLIANLAISDFLVAIVCcPFeMDYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLIL-PF-MAVHVLMDNHWAFGTVLCKVLNS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIPSAYFtTETVLvivKSQEKIFCGQI 254
Cdd:cd15120   78 TLSVGMFTSVFLLTAISLDRYLLTLHPVwsRQHRTNRWASAIVLGVWISAILLSIPYLAF-RETRL---DEKGKTICQNN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVD------------QQIYYKSY-FLFIFGieFVGPVVTMTLCYARISrelwfkavpgfqTEQIRKRLRCRRKTVLVLM 321
Cdd:cd15120  154 YALStnwesaevqasrQWIHVAMFvFRFLLG--FLLPFLIITFCYVRMA------------LKMKERGLARSSKPFKVMF 219
                        250       260
                 ....*....|....*....|....*....
gi 528968953 322 CILTAYVLCWAPF---YGFAIVRDFFPTV 347
Cdd:cd15120  220 TAVVSFFVCWLPYhlhSGLVLTRGRPPSL 248
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
106-234 7.90e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 59.18  E-value: 7.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15304   10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSM-LTILYGYRWPLPSKLCAVWIYLDVLFSTAS 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 186 TNALLAIAIDRYLAIVHPL-RPRMKYQT-ATGLIALVWVVSILVAIPSAYF 234
Cdd:cd15304   89 IMHLCAISLDRYIAIRNPIhHSRFNSRTkAFLKIIAVWTISVGISMPIPVF 139
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
97-376 9.10e-10

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 58.82  E-value: 9.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpFEMDYYVVRQLS--WEHGHVLCASV 174
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV----FSMNLYTLYTVIgyWPLGPVVCDLW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTetVLVIVKSQEKIFCg 252
Cdd:cd15297   77 LALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTkmAGMMIAAAWVLSFILWAPAILFWQ--FIVGGRTVPEGEC- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 qiwpvdqQIYYKSYFLFIFGIE---FVGPVVTMTLCYARISRElwfkavpgfqteqirkrlRCRRKTVL-VLMCILTAYV 328
Cdd:cd15297  154 -------YIQFFSNAAVTFGTAiaaFYLPVIIMTVLYWQISRA------------------SSREKKVTrTILAILLAFI 208
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 528968953 329 LCWAPFYGFAIVRDFFPTVFVKekhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15297  209 ITWTPYNVMVLINTFCASCIPN-----TVWTIGYWLCYINSTINPACY 251
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
106-293 1.21e-09

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 58.62  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFemdYYVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15175   10 ICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTL-PF---WAASAAKKWVFGEEMCKAVYCLYKMSFFSG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIV-----HPLRPRMKYQTATGlIALVWVVSILVAIPsayfttETVLVIVKSQEKIFCGQIWPVDQQ 260
Cdd:cd15175   86 MLLLMCISIDRYFAIVqaasaHRHRSRAVFISKVS-SLGVWVLAFILSIP------ELLYSGVNNNDGNGTCSIFTNNKQ 158
                        170       180       190
                 ....*....|....*....|....*....|...
gi 528968953 261 IYYKSYFLFIFGIEFVGPVVTMTLCYARISREL 293
Cdd:cd15175  159 TLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
103-340 1.24e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 58.63  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMDYYVVRQLsWEHGHVLCASVNYLRTVS 181
Cdd:cd15200    6 VLGIEFVLGlVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFL-IINLPFRIDYYLRNEV-WRFGATACQVNLFMLSMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPsayfttetVLVIVKSQEKIFCGQIWPVDQ 259
Cdd:cd15200   84 RTASIVFLTAIALNRYLKVVHPHHqlSKASVGCAAKVAAGLWILILLLNIH--------LLLLDHVQSNSTCLSYDHGTD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 260 QIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRLRCRRkTVLVLMCILTAYVLCWAPFYGFAI 339
Cdd:cd15200  156 PSASDRWHRILFFLEFFLPLGIILFCIFSIILTL--------KQRKLAKQAGPQR-AVKVLAVIVLVYTVCFLPSILFAL 226

                 .
gi 528968953 340 V 340
Cdd:cd15200  227 A 227
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
106-405 1.26e-09

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 59.64  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPF----EMDyyvvrqlSWEHGHVLCASVNYLRTVS 181
Cdd:PHA02638 107 IIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISD-LIFVIDFPFiiynEFD-------QWIFGDFMCKVISASYYIG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRmKYQT-ATGLIALV--WVVSILVAIPsAYFTTETVLVIVKSQ---EKIFCGQIW 255
Cdd:PHA02638 179 FFSNMFLITLMSIDRYFAILYPISFQ-KYRTfNIGIILCIisWILSLIITSP-AYFIFEASNIIFSAQdsnETISNYQCT 256
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 PVDQQIYYKSYFL---FIFGIEFVG---PVVTMTLCYARISRELwfkavpgfqtEQIRKRLRCrrKTVLVLMCILTAYVL 329
Cdd:PHA02638 257 LIEDNEKNNISFLgriLQFEINILGmfiPIIIFAFCYIKIILKL----------KQLKKSKKT--KSIIIVSIIIICSLI 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 330 CWAP------------FYGFAIVRDFFPTVFVKEKHyltAFYVVECIAMSNSMINTVCFVTVKNNTIKYFKKIML-LHWK 396
Cdd:PHA02638 325 CWIPlnivilfatmysFKGFNSIISEHICGFIKLGY---AMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRnIFTN 401

                 ....*....
gi 528968953 397 ASYNGSKSS 405
Cdd:PHA02638 402 AKFSFRKSS 410
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
131-376 1.35e-09

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 58.43  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 131 TNLLIANLAISDFLVaIVCCPFEMdyYVVRQlSWEHGhVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM-- 208
Cdd:cd15164   35 TRVYMINLAVADCCL-LFSLPFVL--YFLKH-SWPDD-ELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSlr 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 209 KYQTATGLIALVWVVSILVAIpsayfttetVLVIVKSQEKIFCGQiwPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYAR 288
Cdd:cd15164  110 SPRKAALTCGLLWVLVIISVS---------LRLAWEEQEENFCFG--KTSTRPSKRTLIFSLLG--FFIPLIILSFCSIQ 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 289 ISRELWFKavpgfQTEQIRKRlRCRRKTVLVLMCILTAYVLCWAPFYGFAIVR---DFFPTVFVKEKHYLTAFYVVECIA 365
Cdd:cd15164  177 VIRSLKKK-----KKTNPHEE-KLIQKAIYIVSANLIVFIVCFLPLHIGLLVRfvmESNKASCSLIQNIRNFIYVASCLA 250
                        250
                 ....*....|.
gi 528968953 366 MSNSMINTVCF 376
Cdd:cd15164  251 NANCCLDAICY 261
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
126-335 2.82e-09

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 57.73  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 126 KLRNLTNLLI--ANLAISDFLVaIVCCPFEMDYYvvrQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHP 203
Cdd:cd15165   28 KIKKWTESTIymINLALNDLLL-LLSLPFKMHSS---KKQWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 204 LRPRM--KYQTATGLIALVWVVSILVAIPSAYFTTetvlvivKSQEKIFCGQiwPVDQQIYYKSYFLFIFGIEFVGPVVT 281
Cdd:cd15165  104 FLAKRlrSPRKAAIVCLTIWVFVWAGSIPIYSFHD-------KPTNNTRCFH--GFSNKTWSKKVIVVVEEFGFLIPMAV 174
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 282 MTLCYARISRELWFKAVPGFQTEQirkrlrcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15165  175 MVFCSVQIIRTLLDMRRPEQPKVK-------QNKSVKIVLSNLVVFLVCFTPYH 221
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
95-335 3.03e-09

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 57.62  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  95 AKIVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASV 174
Cdd:cd15321    5 ATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGY--WYFRKTWCEIY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSayfttetvlVIVKSQEKIFCG 252
Cdd:cd15321   83 LALDVLFCTSSIVHLCAISLDRYWSVSRAIEynSKRTPRRIKCIILIVWLIAAVISLPP---------LIYKGKQKDEQG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIwPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISrelwfkavpgfqteQIRKRlRCRRKTvLVLMCILTAYVLCWA 332
Cdd:cd15321  154 GL-PQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIY--------------LIAKN-REKRFT-FVLAVVIGVFVLCWF 216

                 ...
gi 528968953 333 PFY 335
Cdd:cd15321  217 PFF 219
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
103-334 3.11e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 57.53  E-value: 3.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAAL-ARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVS 181
Cdd:cd15078    6 LIATIGFLGVCNNLLVLILyYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRG--RWVFDVAGCVWDGFSNSLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPlrPRMKYQTATGLIALVWVVSILVA----IPSAYFTTETvlvivksqEKIFCGQIW-- 255
Cdd:cd15078   84 GIVSIMTLTVLAYERYIRVVHA--KVVNFSWSWRAITYIWLYSLAWTgaplLGWNRYTLEV--------HGLGCSFDWks 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 --PVDQqiyykSYFLFIFGIEFVGPVVTMTLCYARISREL-WFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWA 332
Cdd:cd15078  154 kdPNDT-----SFVLLFFLGCLVVPLGIMAYCYGHILYEIrMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWM 228

                 ..
gi 528968953 333 PF 334
Cdd:cd15078  229 PY 230
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
128-334 4.20e-09

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 57.44  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 128 RNLTNLLIANLAISDFLVaIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPL--R 205
Cdd:cd15117   31 RTVTTVCFLNLAVADFAF-CLFLPFSV-VYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVwaR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 206 PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFC-------------GQIWPVDQQIYYKSYFLFIFG 272
Cdd:cd15117  109 NHRTPARAALVAVGAWLLALALSGPHLVFRD-----TRKENGCTHCylnfdpwnetaedPVLWLETVVQRLSAQVITRFV 183
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 273 IEFVGPVVTMTLCYARISRELWfkavpgfqteqiRKRLRCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd15117  184 LGFLVPLVIIGGCYGLIAARLW------------REGWVHSSRPFRVLTAVVAAFFLCWFPF 233
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
100-335 4.35e-09

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 56.97  E-value: 4.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRT 179
Cdd:cd15309    4 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE--WRFSRIHCDIFVTLDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT---ATGLIALVWVVSILVAIPSAYFTTETvlvivKSQEKIFCGQIWP 256
Cdd:cd15309   82 MMCTASILNLCAISIDRYTAVAMPMLYNTRYSSkrrVTVMISVVWVLSFAISCPLLFGLNNT-----DQNECIIANPAFV 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 257 VDQQIyyksyflfifgIEFVGPVVTMTLCYArisrelwfkavpgfqteQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15309  157 VYSSI-----------VSFYVPFIVTLLVYV-----------------QIYIVLQKEKKATQMLAIVLGVFIICWLPFF 207
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
112-230 4.87e-09

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135  Cd Length: 289  Bit Score: 57.19  E-value: 4.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLS-WEHGHVLCASVNYLRTVSLYVSTNALL 190
Cdd:cd15006   15 LGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHCCwWIYTLLFCKVIKFLHKVFCSVTVLSFA 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528968953 191 AIAIDRYLAIVHPLRPRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15006   95 AIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVP 134
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
113-376 5.11e-09

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 57.25  E-value: 5.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWeHGHVLCASVNYLRTVSlyvSTNALLAI 192
Cdd:cd15069   17 GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDF-HSCLFLACFVLVLTQS---SIFSLLAV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 193 AIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIP------SAYFTTETVLVIVKSQEKIFCGQIWPVDQQIYYK 264
Cdd:cd15069   93 AVDRYLAIKVPLRYKslVTGKRARGVIAVLWVLAFGIGLTpflgwnKAMSATNNSTNPADHGTNHSCCLISCLFENVVPM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 SYFLF--IFGIeFVGPVVTMTLCYARI----SRELWFKAVPGFQTEQIRKRLRCRRKtvlvLMCILTAYVLCWAPFYGFA 338
Cdd:cd15069  173 SYMVYfnFFGC-VLPPLLIMLVIYIKIflvaCRQLQRTELMDHSRTTLQREIHAAKS----LAIIVGIFALCWLPVHILN 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 528968953 339 IVRDFFPTvFVKEKHYLtAFYVVECIAMSNSMINTVCF 376
Cdd:cd15069  248 CITLFQPE-FSKSKPKW-AMNVAILLSHANSVVNPIVY 283
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
102-339 5.14e-09

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 56.75  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIG-NFIFIAALARYKKLRNLTNLLIANLAISDFL-----VAIVCCPFEMDYYVVrqlswehGHVLCASVN 175
Cdd:cd15076    5 AFMGFVFIVGTPlNAIVLFVTIKYKKLRQPLNYILVNISLAGFIfcifsVFPVFVASAQGYFFF-------GRTVCALEA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYFTTEtvlvIVKSQEKIFCGQI 254
Cdd:cd15076   78 FVGSLAGLVTGWSLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLPPFFGWSR----YIPEGLQCSCGPD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIY---YKSYFLFIFGieFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRCRRKTVLVLMcILTAYVLCW 331
Cdd:cd15076  154 WYTVGTKYrseYYTWFLFIFC--FIVPLSIIIFSYSQLLGAL--RAVAAQQQESASTQKAEREVSRMVVV-MVGSFCLCY 228

                 ....*...
gi 528968953 332 APFYGFAI 339
Cdd:cd15076  229 VPYAALAM 236
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
101-230 5.35e-09

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 57.17  E-value: 5.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGI-GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQlsWEHGHVLCASVNYLRT 179
Cdd:cd15127    4 MCLSVVIFGIGImGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKK--WLLGDFSCKIVPYIEV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 180 VSLYVSTNALLAIAIDRYLAIVHplrPRMKYQ------TATGLIALVWVVSILVAIP 230
Cdd:cd15127   82 ASLGVTTFTLCALCIDRFRAATN---VQMYYEmienctSTTAKLAVIWVGALLLALP 135
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
131-378 5.46e-09

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 57.08  E-value: 5.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 131 TNLLIANLAISDfLVAIVCCPFEMDYYVVRQLsWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRpRMKY 210
Cdd:cd16001   35 STIYLVNLAVAD-LLYVCSLPLLIVNYAMRDR-WPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIR-SLAY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 211 QT---ATGLIALVWVVSILVAIPSAYFTTETVLvivksQEKIFCGQIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYA 287
Cdd:cd16001  112 RTrrlAVIGSAATWILVVLQLLPTLVYARTGSI-----NNRTVCYDLTSPDNFGNYFPYGMVLTVTGFLIPFLIILLCYC 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 288 RISRELWFKAvpgfQTEQIRKRLRCRRKTVLVLMCILtaYVLCWAPFYGFAIVRDFFPTVFVKEKHYLT----AFYVVEC 363
Cdd:cd16001  187 LMIKSLIRSE----EAAGVGKAARAKSIRTILLVCGL--FALCFVPFHITRTIYLFVRVYLVQDCPLLQfvslAYKIWRP 260
                        250
                 ....*....|....*
gi 528968953 364 IAMSNSMINTVCFVT 378
Cdd:cd16001  261 LVSFNSCINPLLYFL 275
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
157-382 7.08e-09

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 56.33  E-value: 7.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 157 YVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPR-MKYQTATGLIALVWVVSILVAIPSAYFT 235
Cdd:cd15364   59 YVSNNHKWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRgRRRQRIAAFISFLIFIVVGLVHSPVFIM 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 236 TETvlvivKSQEKIFCGQIWPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYARISRELwfKAVPGFQTEQirkrlrcRRK 315
Cdd:cd15364  139 REG-----QTEGSHTCFETLQMDTQVAGFYYARFCIG--FAIPLAILIFTNYRIFRSI--QTSTSLTPHQ-------KAK 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 316 TVLVLMCILTAYVLCWAPFYGFAIVR----DFFPTVFVK-EKHYLTAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd15364  203 VKYLAIAVIVIFLICFAPYHLVLLVRaiafSLYPNGMCGfEERIYTPSVIFLCLSTVNSVADPIIYVLVSEN 274
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
97-230 7.11e-09

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 56.35  E-value: 7.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEM-----DYYVVRQ---LSWEHGH 168
Cdd:cd15054    1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMlnalyGRWVLARdfcPIWYAFD 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 169 VLCASVNYLRtvslyvstnaLLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15054   81 VMCCSASILN----------LCVISLDRYLLIISPLRykLRMTPPRALALILAAWTLAALASFL 134
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
98-335 7.32e-09

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 56.11  E-value: 7.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  98 VIGMALVGIMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdyyvVRQLS---WEHGHVLCAS 173
Cdd:cd15328    1 VLVLTLLAMLVVATfLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSL----VHELSgrrWQLGRSLCQV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAI-PSAYFTTETVlvivkSQEKIF 250
Cdd:cd15328   77 WISFDVLCCTASIWNVTAIALDRYWSITRHLEytLRTRRRISNVMIALTWALSAVISLaPLLFGWGETY-----SEDSEE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CgqiwPVDQQiyyKSYFLFIFGIEFVGPVVTMTLCYARIsrelwFKAVpgfQTEqirkrlrcrRKTVLVLMCILTAYVLC 330
Cdd:cd15328  152 C----QVSQE---PSYTVFSTFGAFYLPLCVVLFVYWKI-----YKAA---QKE---------KRAALMVGILIGVFVLC 207

                 ....*
gi 528968953 331 WAPFY 335
Cdd:cd15328  208 WIPFF 212
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
90-340 7.64e-09

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 56.41  E-value: 7.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  90 RTFFAAKIVIGMALVGIMLVCGIgnfiFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHV 169
Cdd:cd15084    8 STYLTVAVLMGMVVALASFVNGL----VIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVF--GKT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 170 LCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQek 248
Cdd:cd15084   82 MCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDfRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTS-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 ifCGQIWPVDQQiYYKSYFLFIFGIEFVGPVVTMTLCYARISreLWFKAVPGFQTEQIRKRlRCRRKTVLVLMCILTAYV 328
Cdd:cd15084  160 --CGPNWYTGGT-NNNSYILALFVTCFALPLSTIIFSYSNLL--LTLRAVAAQQKESETTQ-RAEKEVTRMVIAMVMAFL 233
                        250
                 ....*....|..
gi 528968953 329 LCWAPFYGFAIV 340
Cdd:cd15084  234 ICWLPYATFAMV 245
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
114-333 8.87e-09

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 56.31  E-value: 8.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIA 193
Cdd:cd15369   18 NILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLL-PFKIAYHFSGN-DWLFGEAMCRVVTAAFYCNMYCSILLMTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPsayFTTETVLVIVKSQEKIFCGQIWPV-DQQIYYKSYFLFI 270
Cdd:cd15369   96 VDRFLAVVYPMQSLSwrTLRRASFTCAAIWLLSIAGVVP---LLLSEQTIQIPDLGITTCHDVLNEqLLMGYYVYYFSIF 172
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 271 FGIEFVGPVVTMTLCYARISRELWFKAVPGfqteqirkrlRCRRKTVLVLMCI--LTAYVLCWAP 333
Cdd:cd15369  173 SCLFFFVPLIITTVCYVSIIRCLSSSSDVA----------NSSKKTRALFMAVavFCVFVICFGP 227
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
114-335 1.35e-08

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 55.65  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVaiVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIA 193
Cdd:cd15379   18 NAVVIGQIWATRQALSRTTIYMLNLATADLLY--VCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTNLHGSILFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPLRP--RMKYQTATGLI-ALVWVVSILVAIPSAYFTTETVlvivkSQEKIFCGQIWPVDQQIYYKSYFLFI 270
Cdd:cd15379   96 VQRYLGICHPLASwhKKKGKKLTWLVcGAVWLVVIAQCLPTFVFASTGT-----QRNRTVCYDLSPPARSTAYFPYGITL 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 271 FGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRlrcRRKTvlVLMCILTAYVLCWA--PFY 335
Cdd:cd15379  171 TRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEK---RGKA--ARMIIVVAAVFLISflPFH 232
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
91-376 1.51e-08

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 55.55  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  91 TFFAAKIVIGMALVgimlvcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEmdyyVVRQLSWEHGHVL 170
Cdd:cd15070    2 TYISIEILIGLCAV-------VGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLA----IVVSLGVTIHFYS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 171 CASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEK 248
Cdd:cd15070   71 CLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIvtTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 IFCG--QIWPVDQQIYYkSYFLFIfgiefVGPVVTMTLCYARISRELWFKAVPGFQ-TEQIRKRLRCRRKTVLVLMCILT 325
Cdd:cd15070  151 LQCQftSVMRMDYMVYF-SFFTWI-----LIPLVIMCALYVDIFYIIRNKLSQNATgFRETGAFYGREFKTAKSLALVLF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 326 AYVLCWAPFYGFAIVRDFFPTVfvkekhYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15070  225 LFAVCWLPLSIINCVVYFNPKV------PKIALYLGILLSHANSMMNPIVY 269
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
106-335 1.53e-08

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 55.64  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEH---GHVLCASVNYLRTVSL 182
Cdd:cd15975   10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDssfGVFLCKLVPFLQKASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 183 YVSTNALLAIAIDRYLAIVHPLRPR---MKYQTATGLIAlVWVVSILVAIPSAyFTTETVLVIVKSQEKIFCGQIWPVDQ 259
Cdd:cd15975   90 GITVLNLCALSVDRYRAVASWSRVQgigIPLITAIEIFS-IWVLSFILAIPEA-IGFVMVPFEYNGEQYRTCMLNATTKF 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 260 QIYYKSYF-LFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTeQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15975  168 MNFYVDAKdWWLFGFYFCVPLACTAIFYTLMTCEMLNRRKGSLRI-ALSEHLKQRREVAKTVFCLVVIFALCWFPLH 243
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
96-335 1.69e-08

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 55.78  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  96 KIVIGMALVGIMLVCGIGNFIFIAALARYKKLRN-LTNLLIANLAISDFLVAIVCCPFEmdyyVVRQLS--WEHGhvlcA 172
Cdd:cd15320    1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWK----AVAEIAgfWPFG----S 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 173 SVNYLRTVSLYVSTNALL---AIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVA-IPSAY----FTTETVLVI 242
Cdd:cd15320   73 FCNIWVAFDIMCSTASILnlcVISVDRYWAISSPFRyeRKMTPKVAFIMISVAWTLSVLISfIPVQLnwhkAKPTSFLDL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 243 VKSQEKIFCGQIWPVDQQIYYKSYFLfifgIEFVGPVVTMTLCYARISR--ELWFKAVPGFQ-----------TEQIRKR 309
Cdd:cd15320  153 NASLRDLTMDNCDSSLNRTYAISSSL----ISFYIPVAIMIVTYTRIYRiaQKQIRRISALEraavhakncqnSTGNRGS 228
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528968953 310 LRCRR-------------KTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15320  229 GDCQQpessfkmsfkretKVLKTLSVIMGVFVCCWLPFF 267
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
106-340 2.68e-08

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 54.70  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15148   10 IFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIAD-LLLIICLPFRILYHV-NNNQWTLGPLLCKVVGNLFYMNMYIS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 186 TNALLAIAIDRYLAIVHPLRPRMKYQTATGLIA--LVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWpvdqqiyy 263
Cdd:cd15148   88 IILLGFISLDRYLKINRSSRRQKFLTRKWSIVAcgVLWAVALVGFVPMIVLTEKNEESTKCFQYKDRKNAKG-------- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIEFVGPVVTMTLCYARISRELwFKAV---PGFQTEQirKRLRCRRKTVLVLMciltAYVLCWAPFYGFAIV 340
Cdd:cd15148  160 KAIFNFLIVAMFWLVFLLLILSYGKIAKKL-LRISrdkPDFPNAA--KYNRTARKSFFVLF----IFTVCFVPYHAFRIF 232
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
94-376 3.10e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 54.46  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  94 AAKIVIGMALVGIMLVcgiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCAS 173
Cdd:cd15308    1 AAALVGGVLLILAIIA---GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYV-YSEFQGGVWTLSPVLCDA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTEtvlviVKSQEKIFC 251
Cdd:cd15308   77 LMTMDVMLCTASIFNLCAISVDRFIAVSVPLNynRRQGSVRQLLLISATWILSFAVASPVIFGLNN-----VPNRDPAVC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 gqiwpvdqQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKavpgfqteqirkrlrcrRKTVLVLMCILTAYVLCW 331
Cdd:cd15308  152 --------KLEDNNYVVYSSVCSFFIPCPVMLVLYCAMFRGLGRE-----------------RKAMRVLPVVVGAFLFCW 206
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 332 APFYGFAIVRDFFPTVFVKEkhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15308  207 TPFFVVHITRALCESCSIPP----QLISIVTWLGYVNSALNPVIY 247
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
114-344 3.41e-08

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 54.40  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVNYLRT----VSLYVSTNAL 189
Cdd:cd15349   18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTGTS-------YLVNICLSGERTFRLTPALWFLREgllfTALAASTFSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 190 LAIAIDRYLAIVHPLRPRMKYQTAT--GLIALVWVVSILVAIPSayFTTETVLVIVKSqekifCGQIWPvdqqIYYKSYF 267
Cdd:cd15349   91 LVTAVERYATMVRPVAENTATKTYRvyGMIVLCWILAFLIGFLP--LLGWNCLCDFRS-----CSSLLP----LYSKSYI 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 268 LFIFGIeFVGPVVTMTLCYARISRELwfkAVPGFQTEQIRKRLRCRRKTVLVLMcILTAYVLCWAPFYGFAIVrDFF 344
Cdd:cd15349  160 LFCLVI-FFIILLTIIGLYFAIYCLV---RASGQRVISARSRRRSLRLLKTVLM-ILGAFMVCWGPLFILLLV-DFF 230
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
106-230 3.46e-08

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 54.65  E-value: 3.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYyVVRQLSWEHGHVLCASVNYLRTVSLYVS 185
Cdd:cd15218   10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTS-VKNGSTWTYGTLTCKVIAFLGVLSCFHT 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 186 TNALLAIAIDRYLAIVHP--LRPRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15218   89 AFMLFCISVTRYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
113-235 5.47e-08

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 54.09  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 113 GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNYLRTVSLYVSTNALLAI 192
Cdd:cd15316   17 GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSV--ESCWYFGESFCTFHTCCDVSFCYASLFHLCFI 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 193 AIDRYLAIVHPLRPRMKYQTATG--LIALVWVVSILVAIpSAYFT 235
Cdd:cd15316   95 SVDRYIAVTDPLVYPTKFTVSVSgiCISVSWIFSLTYSF-SVFYT 138
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
102-335 5.58e-08

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 53.73  E-value: 5.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGI--GNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVNYLRT 179
Cdd:cd15346    4 SVVFIIICCFIilENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA-------YTANLLLSGATTYKLTPTQWFLRE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNA----LLAIAIDRYLAIVhplrpRMKYQTATG------LIALVWVVS-ILVAIPSAYFTTETVLVIvksqek 248
Cdd:cd15346   77 GSMFVALSAsvfsLLAIAIERYITML-----KMKLHNGSNsfrsflLISACWVISlILGGLPIMGWNCISALSS------ 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 ifCGQIWPvdqqIYYKSYFLFIFGIeFVGPVVTMTLCYARI-------SRELWFKavpgfqtEQIRKRLRCRRKTVLVL- 320
Cdd:cd15346  146 --CSTVLP----LYHKHYILFCTTV-FTLLLLSIVILYCRIyslvrtrSRRLTFR-------KNIRKASRSSEKSMALLk 211
                        250
                 ....*....|....*..
gi 528968953 321 --MCILTAYVLCWAPFY 335
Cdd:cd15346  212 tvIIVLSVFIACWAPLF 228
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
112-230 8.59e-08

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 53.33  E-value: 8.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15126   16 VGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLL--GDVSCRVVPYMEVTSLGVTTFSLCA 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 528968953 192 IAIDRYLAIVHPL---RPRMKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15126   94 LGIDRFHAATSPQpkaRPVERCQSILAKLAVIWVGSMTLAVP 135
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
114-349 1.69e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 52.16  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVA------IVCCPFEMDYYVVRQLSWEHGHvlcaSVNYLRTVSLYvstn 187
Cdd:cd15085   18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMMAlcgttiVTVTNYEGYFYLGDAFCIFQGF----AVNYFGIVSLW---- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 188 ALLAIAIDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQekifCGQIWPVDQQIYYkSY 266
Cdd:cd15085   90 SLTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTS----CSIGWEERSWSNY-SY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 267 FLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfqtEQIRKRLRCR---------RKTVLVLMCILTAYVLCWAPFYGF 337
Cdd:cd15085  165 LILYFLMCFVIPVAIIGFSYGNVLRSL----------HKLNKKIEQQggkncpeeeERAVIMVLAMVIAFLICWLPYTVF 234
                        250
                 ....*....|..
gi 528968953 338 AIVRDFFPTVFV 349
Cdd:cd15085  235 ALIVVVNPELSI 246
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
99-358 2.06e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 51.83  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDF-------LVAIVCCPFEMDYYvVRQLSWEHGhVLC 171
Cdd:cd15136    5 IGVWFVFLLAL--VGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFcmgiylgLLAIVDAKTLGEYY-NYAIDWQTG-AGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 172 ASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAI-PsayfttetvLVIVKSQEK 248
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHlnKRLSLRQAAIIMLGGWIFALIMALlP---------LVGVSSYSK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 249 I-FCgqiWPVD-QQIYYKSYFLFIFGIEFVGpVVTMTLCYARIsrelwFKAVPGFQTEQIRKRLRCRRKtvlvlMCIL-T 325
Cdd:cd15136  152 TsIC---LPFEtETPVSKAYVIFLLLFNGLA-FLIICGCYIKI-----YLSVRGSGRAANSNDTRIAKR-----MALLvF 217
                        250       260       270
                 ....*....|....*....|....*....|....
gi 528968953 326 AYVLCWAPFYGFAIVRDF-FPTVFVKEKHYLTAF 358
Cdd:cd15136  218 TDFLCWAPIAFFGLTAAFgLPLISVSNAKILLVF 251
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
97-376 2.10e-07

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 51.94  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvccpFEMDYYVVRQLS--WEHGHVLCASV 174
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGA----FSMNLYTVYIIKgyWPLGAVVCDLW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFTTetvlvIVKSQEKIFCG 252
Cdd:cd15298   77 LALDYVVSNASVMNLLIISFDRYFCVTKPLTypARRTTKMAGLMIAAAWVLSFVLWAPAILFWQ-----FVVGKRTVPDN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWpvdqqIYYKSYFLFIFGI---EFVGPVVTMTLCYARISrelwfkavpgfqTEQIRKrlrcrRKTVLVLMCILTAYVL 329
Cdd:cd15298  152 QCF-----IQFLSNPAVTFGTaiaAFYLPVVIMTVLYIHIS------------LASARE-----RKVTRTIFAILLAFIL 209
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528968953 330 CWAPFYGFAIVRDFFPTVFVKekhylTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15298  210 TWTPYNVMVLVNTFCQSCIPD-----TVWSIGYWLCYVNSTINPACY 251
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
133-372 4.40e-07

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 50.95  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 133 LLIANLAISDfLVAIVCCPFEMDYYVVRQlSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPL-RPRMKYQ 211
Cdd:cd15370   37 IYMANLALAD-LLFVIWFPLKIAYHINGN-NWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMsHSRKKAN 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 212 TATGLIALVWVVSILVAIPsAYFTTETVLviVKSQEKIFCGQIWPVDQQIYYK-SYFLFIFGIEFVGPVVTMTLCYARIS 290
Cdd:cd15370  115 IAIGISLAIWLLILLVTIP-LYLVKQTVF--IPALDITTCHDVLPEQLLVGDMfNYFLSLAIGVFLFPAFLTAVAYVLMI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 291 RELwfkaVPGFQTEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYGFAIVRdfFPTVFVKEKHYLTAFYVVE-CIAMSNS 369
Cdd:cd15370  192 RAL----KSSINDESIEKK---RKRAIKLIVTVLVMYLICFTPSNLLLVVH--YFLLKNQGQSSVYAFYITAlCLSTLNS 262

                 ...
gi 528968953 370 MIN 372
Cdd:cd15370  263 CID 265
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
97-376 4.67e-07

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 50.93  E-value: 4.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd14988    1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWM-LEVMLDYTWLWGSFLCKFTHY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSayfTTETVLVIVKSQEKIFCGQI 254
Cdd:cd14988   79 FYFANMYSSIFFLTCLSVDRYLTLTSSSPFwqQHQHRIRRALCAGIWVLSAIIPLPE---VVHMQLLDGVEPMCLFLAPF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 WPVDQQIYYKSYFLFIFGieFVGPVVTMTLCYARISRELwfkavpgfqteQIRKRLRCRRKTVLVLMCILTaYVLCWAPF 334
Cdd:cd14988  156 ETYDEWALAVSLLTLIIG--FLIPFSIIAVFNVLTARYI-----------RTAGRPESRRHCLLIYAYILV-FVVCWLPY 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 528968953 335 Y--GFAIVRDFFPTVF-VKEKHYLTAFY-VVECIAMSNSMINTVCF 376
Cdd:cd14988  222 HvtLLLLTLHGSHISLhCNLVHFLYFFYdVIDCFSLLHCVANPILY 267
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
114-338 5.15e-07

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 50.99  E-value: 5.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLvaIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIA 193
Cdd:cd15080   18 NFLTLYVTVQHKKLRTPLNYILLNLAVADLF--MVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPLRP-RMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQekifCG-QIWPVDQQIYYKSYFLFIF 271
Cdd:cd15080   96 IERYVVVCKPMSNfRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCS----CGiDYYTLKPEVNNESFVIYMF 171
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 272 GIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRCRRKTVLVLMCILtAYVLCWAPFYGFA 338
Cdd:cd15080  172 VVHFTIPLIVIFFCYGRLVCTV--KEAAAQQQESATTQKAEKEVTRMVIIMVI-AFLICWVPYASVA 235
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
112-230 6.18e-07

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 50.56  E-value: 6.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVvrQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15153   16 LANSAALWVLCRFISKKNKAIIFMINLAVAD-LAHVLSLPLRIHYYI--QHTWPFGRFLCLLCFYLKYLNMYASICFLTC 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLRPR-MKYQTATGLIALVWVVSILVAIP 230
Cdd:cd15153   93 ISIQRCFFLLHPFKARdWKRRYDVGISAAVWIVVGLACLP 132
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
95-231 6.26e-07

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 50.62  E-value: 6.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  95 AKIVIGMALVGIMlvcgiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdyYVVRQLSWEHGHVLCASV 174
Cdd:cd15403    4 AIVMILMIAIGFL-----GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTA--VTIITVDWHFGAHFCRIS 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 175 NYLRTVSLYVSTNALLAIAIDRYLAIVHPlRPRMKYQTATGLIALVWVVSILVAIPS 231
Cdd:cd15403   77 AMLYWFFVLEGVAILLIISVDRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPS 132
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
114-376 1.22e-06

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 49.78  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAivcCPFEMDYYVVRQLSWEHGHVLCASvnyLRTVSLYVSTNALLAIA 193
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAG---LGLILHFVFRYCVYSEALSLVSVG---LLVAAFSASVCSLLAIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 194 IDRYLAIVHPL---RPRMKYQTATgLIALVWVVSILV-AIPsayfttetVLVIVKSQEKIFCGQIWPVDQQ--IYYKSYF 267
Cdd:cd15100   92 VDRYLSLYNALtyySERTLTFTYV-MLALLWTLALGLgLLP--------VLGWNCLREGSSCSVVRPLTKNhlAVLAVAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 268 LFIFGIefvgpvvtMTLCYARISRELWFKAvpgfqtEQIRKRLRC--------RRKTVLVLMCILTAYVLCWAPFYGFAI 339
Cdd:cd15100  163 LLVFAL--------MLQLYAQICRIVLRHA------HQIALQRHFlapshyvaTRKGVSTLALILGTFAACWIPFAVYCL 228
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 528968953 340 VRDF-FPTVFVkekhyltafYVVECIAMSNSMINTVCF 376
Cdd:cd15100  229 LGDGsSPALYT---------YATLLPATYNSMINPIIY 257
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
101-229 1.44e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.55  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCGI-GNFIFIAALARYKKLRNLTN--LLIANLAISDFLVAIVCCPFEMDYYVvRQLSWEHGHVLCASVNYL 177
Cdd:cd14981    4 PAPPALMFVFGVlGNLLALIVLARSSKSHKWSVfyRLVAGLAITDLLGILLTSPVVLAVYA-SNFEWDGGQPLCDYFGFM 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVAI 229
Cdd:cd14981   83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLgaVWAFALLIAS 136
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
131-334 1.83e-06

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 49.18  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 131 TNLLIANLAISDFLVAIVCcPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKY 210
Cdd:cd15170   36 IDILLLNLTVSDLIFLLFL-PFKM-AEAASGMIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 211 QTATGLIALV--WVVS----ILVAIPSAYFTTETVLVivksQEKIFCGQIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTL 284
Cdd:cd15170  114 RPLYAVIASVffWVLAfshcSIVYIVEYHIDSENTSV----TNNSRCYDNFTPEQLKILLPVRLELFLVLFCIPFLITCF 189
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 285 CYARISRELwfkavpgfQTEQIRKRLRCRRKTVLVLmCILTAYVLCWAPF 334
Cdd:cd15170  190 CYINFIRIL--------SSLPHISRQRKQRAIGLAV-ATLLNFIVCFAPY 230
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
100-335 1.87e-06

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 49.05  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 100 GMALVGIMLVCG---IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVNY 176
Cdd:cd15345    1 DLTTIFFLVICSfivLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIA-------YKVNILMSGKKTFSLSPTQWF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYV----STNALLAIAIDRYLAIVHpLRP--RMKYQTATGLIALVWVVSILV-AIPSAYFTTETVLVIvksqeki 249
Cdd:cd15345   74 LREGSMFValgaSTFSLLAIAIERHLTMIK-MRPydANKRYRVFLLIGTCWLISVLLgALPILGWNCLDNLPD------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 fCGQIWPvdqqIYYKSYFLFIFGIeFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVlmciLTAYVL 329
Cdd:cd15345  146 -CSTILP----LYSKKYVAFCISI-FIAILVAIVILYARIYILVKSSSRRVTNHRNSERSMALLRTVVIV----VGVFIA 215

                 ....*.
gi 528968953 330 CWAPFY 335
Cdd:cd15345  216 CWSPLF 221
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
112-333 2.82e-06

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 48.72  E-value: 2.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdyYVVrqLSWEHGHV---LCASVNYLRT----VSLYV 184
Cdd:cd15343   16 VSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIA--------YVF--LMFNTGPVsktLTVNRWFLRQglldTSLSA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVH-PLRPRMKYQTATGLIALVWVVSILV-AIPSAYFTTETVLVIvksqekifCGQIWPvdqqIY 262
Cdd:cd15343   86 SLTNLLVIAVERHISIMRmKVHSNLTKRRVTLLIALVWAIAIFMgAVPTLGWNCICNISA--------CSSLAP----IY 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528968953 263 YKSYFLFiFGIEFVGPVVTMTLCYARISRELWFKA-VPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15343  154 SRSYLVF-WSVSNLVVFLIMVVVYLRIYVYVQRKTnVLSPHTSGSINRRRTPIKLMKTVMTVLGAFVICWTP 224
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
114-376 3.17e-06

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 48.28  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVNYLRT----VSLYVSTNAL 189
Cdd:cd15348   18 NLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAA-------YAANILMSGANTLKLTPALWFLREggvfITLTASVFSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 190 LAIAIDRYLAIVhplrpRMK-YQTAT-----GLIALVWVVSILVAIPSAYFTTetvlVIVKSQEkifCGQIWPvdqqIYY 263
Cdd:cd15348   91 LAIAIERHITMV-----RMKpYPGDKrgrmfLLIGAAWLVSILLGVLPILGWN----CLGNLDA---CSTVLP----LYA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 264 KSYFLFIFGIeFVGPVVTMTLCYARISRELWFKAvPGFQTEQIRKRLRCRRKTVLVLMCILT----AYVLCWAPFYGFAI 339
Cdd:cd15348  155 KSYILFCITV-FLAILAAIVVLYARIYRIVKANS-QRLGALPTRKGRARRSQKYLALLKTVTivlgTFVACWLPLFLLLL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 528968953 340 VRDFFPT----VFVKEKHYLTafyvvecIAMSNSMINTVCF 376
Cdd:cd15348  233 LDVSCPAqacpVLLKADYFLG-------LAMINSLLNPIIY 266
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
112-337 4.18e-06

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 47.83  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLtnLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15220   15 VGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSVCLVSASILTISA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPS--AYFTTETVLVIVKSQekifCGQIWPVDQqiyYKSYF 267
Cdd:cd15220   93 ISVERYYYIVHPMRyeVKMTIGLVAAVLVGVWVKALLLGLLPvlGWPSYGGPAPIAARH----CSLHWSHSG---HRGVF 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528968953 268 LFIFG-IEFVGPVVTMTLCYARIsrelwFKAVPGfqteqirkrlrcrRKTVLVLMCILTAYVLCWAPFYGF 337
Cdd:cd15220  166 VVLFAlVCFLLPLLLILVVYCGV-----FKVFGG-------------GKAALTLAAIVGQFLCCWLPYFAF 218
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
97-376 6.20e-06

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 47.53  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVCGIGNFIFIAALARYKKLRNLTN-LLIANLAISDFLVAIV-CCPFeMDYYVVRQLSWEHGHVL-CAS 173
Cdd:cd15341    1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLRRKPSyLFIGSLALADFLASVVfACSF-VDFHVFHGVDSSAIFLLkLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 VnylrTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVA-IPSAYFTTetvlvivkSQEKIF 250
Cdd:cd15341   80 V----TMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALavMWVLTALIAyLPLMGWNC--------CPLNSP 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 CGQIWPVDQQIYYKSYFLFIFgIEFVGPVVTmtlcYARIsreLWfKA------VPGFQTEQIRKRLRCRRKTVL--VLMC 322
Cdd:cd15341  148 CSELFPLIPNDYLLSWLLLVA-ILLSGIIYT----YGHV---LW-KAhkhvvyMEKHQDQQGPGNARMRLDVRLakTLGL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528968953 323 ILTAYVLCWAPfygfAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15341  219 VLAVLLICWSP----VLALMMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIY 268
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
99-233 8.02e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.64  E-value: 8.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVG-IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSWEHGHVLCASVNYL 177
Cdd:cd15217    2 VKLVLLGlIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVL-VSIRNGSAWTYSVLSCKIVAFM 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 178 RTVSLYVSTNALLAIAIDRYLAIVHP--LRPRMKYQTATGLIALVWVVSILVAIPSAY 233
Cdd:cd15217   81 AVLFCFHAAFMLFCISVTRYMAIAHHrfYSKRMTFWTCIAVICMVWTLSVAMAFPPVF 138
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
104-341 8.54e-06

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 47.10  E-value: 8.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 104 VGIMLVCGIG---NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIvCCPFEMDYYvvrqlSWEHGHVLCASVNYLRTV 180
Cdd:cd15920    5 VMYSIICIVGllsNTLALWVFFLRQQRETSISVYMRNLALADLLLVL-CLPFRVAYQ-----NTAGPLSFCKIVGAFFYL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRpRMKYQT---ATGLIALVWVVSILVAIPSAYFTTETvlviVKSQEKIF------- 250
Cdd:cd15920   79 NMYASILFLSLISLDRYLKIIKPLQ-QFKIHTvpwSSAASGGVWLLLLACMIPFLFESRNE----GPCDNKCFhfrskgl 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 251 -CGQIWPVDQQIYYKSYFLFIFgiefvgpvvtmtlCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMciltAYVL 329
Cdd:cd15920  154 tAGGINLTAVVIFYILSLLFLY-------------FYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLA----IFIV 216
                        250
                 ....*....|..
gi 528968953 330 CWAPFYgfaIVR 341
Cdd:cd15920  217 CFVPYH---IVR 225
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
137-380 9.10e-06

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 47.01  E-value: 9.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 137 NLAISDFLVAIVCcPFeMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRP--RMKYQTAT 214
Cdd:cd15922   41 NLALSDAIITPAA-PL-LIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKslWKKKSFMK 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 215 GLIALVWVVSILVAIPSAYFTTETVLvivksQEKIFCGQIWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISrelw 294
Cdd:cd15922  119 KLCLGVWLLLFVQGLPFFFVLKTSVI-----DGKTKCLSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLG---- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 295 fKAVPGFQTEQIRKRLRCRRKTVLVLMCiLTAYVLCWAPFY----GFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSM 370
Cdd:cd15922  190 -ASIAKMNSNNARGRAMKAKSLQMIGIS-LVIFIICFVPLHvtrtVGVVVKLFYPESCTLLHKVEVAYYISWVLTGVNCC 267
                        250
                 ....*....|..
gi 528968953 371 INTV--CFVTVK 380
Cdd:cd15922  268 LDPLlyCFASEK 279
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
133-376 9.16e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 47.14  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 133 LLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVL-CASVnylrTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQ 211
Cdd:cd15099   38 LFIGSLALADMLASVIFTISFLDFHVFHQRDSRNLFLFkLGGV----TMAFTASVGSLLLTALDRYLCIYQPSNYKLLVT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 212 TATGLIA--LVWVVSILVA-IPSAYFTTETVLVIvksqekifCGQIWPVDQQIYYKSYFLFIfGIEFVGPVVTMTLCYAR 288
Cdd:cd15099  114 RTRAKVAilLMWCVTIIISfLPLMGWRCKTWDSP--------CSRLFPYIDRHYLASWTGLQ-LVLLFLIIYAYPYILWK 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 289 ISRELWFKAVPGFQTEQIRKRLRCRRKTVL--VLMCILTAYVLCWAPFYGFAIVrDFFPTVFVKEKhylTAFYVVECIAM 366
Cdd:cd15099  185 AHRHEANMGGPKLGRQQVKGQARMRMDIRLakTLSLILLVLAICWLPVLAFMLV-DVRVTLTNKQK---RMFAFCSMLCL 260
                        250
                 ....*....|
gi 528968953 367 SNSMINTVCF 376
Cdd:cd15099  261 VNSCVNPIIY 270
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
114-376 1.23e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 46.42  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVA-------IVCCPFEMDYYVVRQLSWEHGHVLCASvnyLRTVSLYVST 186
Cdd:cd15352   18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvsnsletIMIAVLNSGYLVISDQFIQHMDNVFDS---MICISLVASI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 187 NALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFtTETVLVIVKSQEKIFCgqiwpvdqqiyyk 264
Cdd:cd15352   95 CNLLAIAVDRYVTIFYALRYHsiMTVRKALVLIAVIWVVCIVCGIVFIVY-SESKTVIVCLITMFFA------------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 265 syFLFIFGIEFVGPVVTMTLCYARISrelwfkAVPGFQTEQIRKRlRCRRKTVLVLMcILTAYVLCWAPFYGFAIVRDFF 344
Cdd:cd15352  161 --MLVLMATLYVHMFLFARLHVKRIA------ALPPAVDGAPQQR-SCMKGAVTITI-LLGVFIVCWAPFFLHLILIISC 230
                        250       260       270
                 ....*....|....*....|....*....|..
gi 528968953 345 PTVFVKEKhYLTAFYVVECIAMSNSMINTVCF 376
Cdd:cd15352  231 PHNPYCLC-YTSHFNTYLVLIMCNSVIDPLIY 261
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
96-333 1.28e-05

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 46.35  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  96 KIVIGMALVGIMLVCgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVccpfemdYYVVRQLSWEHGHVLCASVN 175
Cdd:cd15101    1 VLVMGLGITVCIFIM-LANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLA-------YFFLMFNTGPNTRRLTVSTW 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 176 YLRT----VSLYVSTNALLAIAIDRYLAIVH-PLRPRMKYQTATGLIALVWVVSILV-AIPSAYFTTETVLVIvksqeki 249
Cdd:cd15101   73 FLRQglldTSLTASVANLLAIAVERHISVMRmQLHSRLSNRRVVVLIVLVWTMAIVMgAIPSVGWNCLCAIDA------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 250 fCGQIWPvdqqIYYKSYFLFiFGIEFVGPVVTMTLCYARISreLWFKAVPGFQTEQIRKRLRCRRKTVLVL---MCILTA 326
Cdd:cd15101  146 -CSNMAP----LYSRSYLVF-WAISNLVTFLVMVVVYARIF--VYVRRRTNRMSPHTSGSIRNRDTMMSLLktvVIVLGA 217

                 ....*..
gi 528968953 327 YVLCWAP 333
Cdd:cd15101  218 FVVCWTP 224
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
115-382 1.31e-05

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 46.67  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 115 FIFIAALA----------RYKKLRNLTNLLIANLAISDFLVaIVCCPFEMdYYVVRQLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd14987    9 FIFVIGLLansvvvwvnlQAKRTGYETHLYILNLAIADLCV-VATLPVWV-VSLVQHNQWPMGEFTCKITHLIFSINLFG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 STNALLAIAIDRYLAIVHPLRP--RMKYQTATGLIALVWVVSILVAIPSAYFTTetvLVIVKSQEKIFCGQIWPVDqqiY 262
Cdd:cd14987   87 SIFFLTCMSVDRYLSVTLFGNTssRRKKIVRRIICVLVWLLAFVASLPDTYFLK---TVTSPSNNETYCRSFYPEE---S 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKSYF----LFIFGIEFVGPVVTMTLCYARISRELwfkavpgfqTEQIRKRLRCRRKTVLVLMCIltaYVLCWAPFYGFA 338
Cdd:cd14987  161 FKEWLigmeLVSIVLGFVIPFPIIAVFYFLLARAI---------SASSDQERKSSRKIIFSYVVV---FLVCWLPYHTVV 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 339 IVR-----DFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNN 382
Cdd:cd14987  229 LLDilsflHLIPFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRN 277
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
114-345 1.52e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 46.44  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEmdyyVVRQLS--WEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:cd15081   30 NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTIS----VVNQIFgyFILGHPMCVLEGFTVSVCGITGLWSLTI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 192 IAIDRYLAIVHPL-RPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQ--EKIFCGQIWPVDQqiyykSYFL 268
Cdd:cd15081  106 ISWERWVVVCKPFgNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKTScgPDVFSGSSDPGVQ-----SYMI 180
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 269 FIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLmciLTAYVLCWAPFYGFAIVRDFFP 345
Cdd:cd15081  181 VLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKEVSRMVVVM---IFAYCFCWGPYTFFACFAAANP 254
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
97-349 1.54e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 46.31  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  97 IVIGMALVGIMLVcgIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWehGHVLCASVNY 176
Cdd:cd15075    3 LSIIMAVFSIASV--VLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNL--GRVGCVLEGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 177 LRTVSLYVSTNALLAIAIDRYLAIVHPLrPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQekifCGQI 254
Cdd:cd15075   79 AVAFFGIAALCTVAVIAVDRLFVVCKPL-GTLTFQTrhALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTS----CAPD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 255 W----PVDQQiYYKSYFLFIFGIefvgPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMciLTAYVLC 330
Cdd:cd15075  154 WysrdPVNVS-YILCYFSFCFAI----PFAIILVSYGYLLWTLRQVAKLGVAEGGSTAKAEVQVARMVVVM--VMAFLLC 226
                        250
                 ....*....|....*....
gi 528968953 331 WAPFYGFAIVRDFFPTVFV 349
Cdd:cd15075  227 WLPYAAFALTVVSKPDVYI 245
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
164-335 1.69e-05

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 46.29  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 164 WEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--ATGLIALVWVVSILVAIPSAYFTTETVL- 240
Cdd:cd15924   65 WQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVsfAKILSVVVWALMFLLSLPNMILTNQQPRe 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 241 --VIVKSQEKIFCGQIWpvDQQIYYksYFLFIFGIEFvgpvVTMTLCYARISRELWFKAVPGFQTEQIRkrlrcRRKTVL 318
Cdd:cd15924  145 knVKKCSFLKSELGLKW--HEIVNY--ICQVIFWIVF----LLMIVCYTAITKKVYRSYRRVFRSSSSR-----RKKSNV 211
                        170
                 ....*....|....*..
gi 528968953 319 VLMCILTAYVLCWAPFY 335
Cdd:cd15924  212 KIFIIVAVFFVCFVPYH 228
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
103-225 2.17e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 45.91  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 103 LVGIMLVCGIGNFIFIAALARYKKLR-NLTNLLIANLAISDFLVAIVCCPFEMdYYVVRQLSwEHGHVLCASVNYLRTvs 181
Cdd:cd15219    6 LVVVLVVSLLSNLLVLLCFLYSAELRkQVPGIFLLNLSFCNLLLTVLNMPFTL-LGVVRNRQ-PFGDGFCQAVGFLET-- 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 182 lYVSTNALL---AIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSI 225
Cdd:cd15219   82 -FLTSNAMLsmaALSIDRWIAVVFPLSytSKMRYRDAALMVGYSWLHSL 129
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
112-390 2.38e-05

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 46.05  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALArYKKLRNLTNLLIANLAISDFLVAivccpFEMDYYVVRQLS-WEHGHVLCASVNYLRTVSLYVSTNALL 190
Cdd:PHA02834  44 IGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLV-----FSFPFIIHNDLNeWIFGEFMCKLVLGVYFVGFFSNMFFVT 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 191 AIAIDRYLAIVHPLRPRMKYQTATGLIAL-VWVVSILVAIPsayfttetVLVIVKSQEKIFCGQIWPVDQQIYYKSYFLF 269
Cdd:PHA02834 118 LISIDRYILVVNATKIKNKSISLSVLLSVaAWVCSVILSMP--------AMVLYYVDNTDNLKQCIFNDYHENFSWSAFF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 270 IFGIEFVGPVVTMTL---CYARISRELwfkavpgfqtEQIRKRLRCRrkTVLVLMCILTAYVLCWAPFYGFAIVRDFFPT 346
Cdd:PHA02834 190 NFEINIFGIVIPLIIliyCYSKILYTL----------KNCKNKNKTR--SIKIILTVVTFTVVFWVPFNIVLFINSLQSV 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 347 VFVKEKHY-----LTAFYVVECIAMSNSMINTVCFVTVKNNTIKYFKKI 390
Cdd:PHA02834 258 GLIDIGCYhfkkiVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNM 306
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
101-203 3.26e-05

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 45.57  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 101 MALVGIMLVCG-IGNFIFIAALARYKKLRNLTNL--LIANLAISDFLVAIVCCPFEMDYYVvrQLSWEHGHVLCasvNYL 177
Cdd:cd15142    4 PTIPAVMFIFGvVGNLIAIVVLCKSRKEQKETTFytLVCGLAVTDLLGTCLASPVTIATYL--KGRWPGGQPLC---EYF 78
                         90       100
                 ....*....|....*....|....*....
gi 528968953 178 RTVSLYVSTNAL---LAIAIDRYLAIVHP 203
Cdd:cd15142   79 SFILLFFSLSGLsiiCAMSIERYLAINHA 107
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
128-372 3.58e-05

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 44.94  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 128 RNLTNLLIANLAISDFLVaiVCCpfEMDYYVVRQLsweHGHVLCASVNYLRTVSLYVSTNA----LLAIAIDRYLAIVHP 203
Cdd:cd14973   31 RNPFSVYILNLAAADFLF--LSC--QAIQSLEDLL---GGSLPGFALCRLLATLMFFSYTVglslLAAISTERCLSVLFP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 204 L-----RPRmkyQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSqekiFCgqiwpvdqqiyykSYFLFIFGIEFVGP 278
Cdd:cd14973  104 IwyrchRPK---HLSAVVCALLWALSLLLSVLESYFCGFLFWKFNES----AC-------------RTFNFLSALLFLLL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 279 VVTMTLC----YARISRELWfkavpgfqteqirkRLRCRRKTVLVLMCILtAYVLCWAPFYGFAIVRDFFPTVFVKEKHY 354
Cdd:cd14973  164 FLVMCVSsltlLIRVQCSSQ--------------RRPPTRLYVVILLTVL-VFLLCGLPLGIYWFLLLWFSNYLFHTFHP 228
                        250
                 ....*....|....*...
gi 528968953 355 LtaFYVVECIamsNSMIN 372
Cdd:cd14973  229 I--SDLLSCV---NSSAN 241
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
99-376 3.65e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 45.22  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVgIMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWeHGHVLCASVNYLR 178
Cdd:cd15071    4 IGIEVL-IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF-YSCLMVACPVLIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSlyvSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPS--------------AYFTTETVLVI 242
Cdd:cd15071   82 TQS---SILALLAIAVDRYLRVKIPTRYKSvvTPRRAAVAIAGCWILSFLVGLTPmfgwnnlnaverawAANSSMGELVI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 243 VKSQEKIFcgqiwpvdqQIYYKSYFLFIFGIefVGPVVTMTLCYARI---SRELWFKAVPGFQTEQiRKRLRCRRKTVLV 319
Cdd:cd15071  159 KCQFETVI---------SMEYMVYFNFFVWV--LPPLLLMLLIYLEVfylIRKQLNKKVSSSSSDP-QKYYGKELKIAKS 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528968953 320 LMCILTAYVLCWAPFYGFAIVRDFFPTvfVKEKHYLTafYVVECIAMSNSMINTVCF 376
Cdd:cd15071  227 LALILFLFALSWLPLHILNCITLFCPS--CKKPMILT--YIAIFLTHGNSAMNPIVY 279
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
102-335 4.89e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 44.81  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 102 ALVGIMLVCGIGNFIFIAALARYK---KLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLR 178
Cdd:cd15166    3 ALVFYSFIFIIGLFVNITALWVFScttKKRTTVTVYMMNVALVD-LIFILSLPFRMVYYAKD--EWPFGDYFCRILGALT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSLYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLIAL--VWVVSILVAIPSAYFTTE-----TVLVIVKSQEKIFC 251
Cdd:cd15166   80 VFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACvgVWIMTLASTFPLLFLYEDpdkasNFTTCLKMLDIIHL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIWPVDqqiYYKSYFLFIFgiefvgPVVTMTLCYARISRELwfkaVPGfQTEQIRKRLrcRRKTVLVLMCILTAYVLCW 331
Cdd:cd15166  160 KEVNVLN---FTRLIFFFLI------PLFIMIGCYLVIIHNL----VHG-RTSKLKPKV--KEKSIRIIITLIVQVLVCF 223

                 ....
gi 528968953 332 APFY 335
Cdd:cd15166  224 VPFH 227
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
114-334 5.19e-05

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 44.73  E-value: 5.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIA-NLAISDfLVAIVCCPFEmdyyVVRQLS--WEHGHVLCASVNYLRTVSLYVSTNALL 190
Cdd:cd14983   18 NLLALYAFVNRARLRLTPNVIYMiNLCLSD-LVFILSLPIK----IVEALSsaWTLPAVLCPLYNLAHFSTLYASTCFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 191 AIAIDRYLAIVHP----LRPRMKYQTATGLIALVWVVSILVAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQIYYKSY 266
Cdd:cd14983   93 AISAGRYLGVAFPikyqLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGTLDINTPVGNSSTCYENFTPEQLALLAPV 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 267 FLFIFGIEFVGPVVTMTLCYARISRELwfkavpgfqteqIRKRL--RCRRKTVLVLMCILTAYVLCWAPF 334
Cdd:cd14983  173 RLELSLVLFFLPLAITAFCYVRCIRIL------------VRSRLheRRKRRAVRVAVSTLLTFVVCFGPY 230
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
92-224 6.72e-05

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 44.27  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  92 FFAAKIVIGMALVGIMLvcgigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRqlsWEHGHVLC 171
Cdd:cd15072    1 FAVGSILLVEALVGFSL-----NGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRR---WPYGSEGC 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528968953 172 ASVNYLRTVSLYVSTNALLAIAIDRYLAIVHplRPRMKYQTATGLIALVWVVS 224
Cdd:cd15072   73 QAHGFQGFFTALASICSSAAIAWDRYHHYCT--RSKLQWSTAISLVLFVWLFS 123
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
114-242 8.25e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 44.02  E-value: 8.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVA-------IVCCPFEMDYYVVRQLSWEHghvLCASVNYLRTVSLYVST 186
Cdd:cd15103   18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaletIVIILLNNGYLVPRDSFEQH---IDNVIDSMICSSLLASI 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528968953 187 NALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIPSAYFTTETVLVI 242
Cdd:cd15103   95 CSLLAIAVDRYITIFYALRYHsiMTVRRAGVIITAIWVFCTVCGILFIIYSDSVPVII 152
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
99-376 8.97e-05

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 43.73  E-value: 8.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCcpfeMDYYVVRQLSWEHGHVLCASVNYLR 178
Cdd:cd15960    5 IALCVTGTVMACE--NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGL----IANFVAIYVMNSEAVTLCSAGLLLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSlyVSTNALLAIAIDRYLAIVHPLrprmKYQT------ATGLIALVWVVSILV-AIPSAYFTTetvlvivkSQEKIFC 251
Cdd:cd15960   79 AFS--ASVCSLLAITVDRYLSLYNAL----TYHTertltfTYGLLALLWLTCIGIgLLPAMGWNC--------LRAPASC 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQIWPV--DQQIYYKSYFLFIFGIefvgpvvtMTLCYARISRELWFKAVPGFQTEQIRKRLRC--RRKTVLVLMCILTAY 327
Cdd:cd15960  145 SVLRPVtkNNAAVLAVSFLLLFAL--------MMQLYLQICRIAFRHAQQIAVQHQFVNFCLAssTRKGVSTLSLILATF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 328 VLCWAPFYGFAIVRD-FFPTVFVkekhyltafYVVECIAMSNSMINTVCF 376
Cdd:cd15960  217 AFCWVPFAVYSMVADsSYPMIYT---------YYLVLPAACNSVINPIIY 257
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
106-205 9.01e-05

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 43.95  E-value: 9.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCG-IGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVRqlSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15152    9 VILIPGlIGNVLALWVFYAYVKETKRAVIFMINLAIAD-LLQVLSLPLRIFYYLNK--SWPFGKFLCMFCFYLKYVNMYA 85
                         90       100
                 ....*....|....*....|.
gi 528968953 185 STNALLAIAIDRYLAIVHPLR 205
Cdd:cd15152   86 SIYFLVCISVRRCLYLIYPFR 106
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
105-376 1.02e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 43.86  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCpfemdyyvvrqLSWEHGHVLCASVNYLRTVSLYV 184
Cdd:cd15961   11 GTLISCE--NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLI-----------LNFIFAYLLQSEAAKLVTVGLIV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 185 -----STNALLAIAIDRYLAIVHPLRPRMKYQTATGLIALV--WVVSILVAIPSayfttetVLVIVKSQEKIFCGQIWPV 257
Cdd:cd15961   78 asfsaSVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVllWGASICLGLLP-------VMGWNCLADESTCSVVRPL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 258 DQQ--IYYKSYFLFIFGI--EFVGPVVTMTLCYA-RISRELWFKAVPGFQTEqirkrlrcrRKTVLVLMCILTAYVLCWA 332
Cdd:cd15961  151 TKNnaAILSVSFLLMFALmlQLYIQICKIVMRHAhQIALQHHFLATSHYVTT---------RKGVSTLAIILGTFAACWM 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 528968953 333 PFYGFAIVRDF-FPTVFVkekhyltafYVVECIAMSNSMINTVCF 376
Cdd:cd15961  222 PFTLYSLIADYtYPSIYT---------YATLLPATYNSIINPVIY 257
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
112-252 1.27e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 43.40  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHvlCASVNYLRTVSLyvSTNALL- 190
Cdd:cd15232   16 TGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGG--CMAQLYFFTWSL--GSELLLl 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 191 -AIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAipsayfTTETVLVIVKSqekiFCG 252
Cdd:cd15232   92 tAMAYDRYVAICHPLHysTIMRKEVCVGLATGVWAIGMLNS------AVHTGLMLRLS----FCG 146
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
99-376 2.90e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 42.23  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  99 IGMALVGIMLVCGigNFIFIAALARYKKLRNLTNLLIANLAISDFLVAivccpFEMDYYVVRQLSWEHGHVLCASVNYLR 178
Cdd:cd15962    5 IMLCISGTVIACE--NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAG-----CGLILNFVFQYVIQSETISLITVGFLV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TvSLYVSTNALLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSayfttetVLVIVKSQEKIFCGQIWP 256
Cdd:cd15962   78 A-SFTASVSSLLAITVDRYLSLYNALTyySEKTVLGVHLMLAATWGVSLCLGLLP-------VLGWNCLEERASCSIVRP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 257 VDQQ--IYYKSYFLFIFGIefvgpvvtMTLCYARISRELWFKAvpgfqtEQIRKRLRC--------RRKTVLVLMCILTA 326
Cdd:cd15962  150 LTKSnvTLLSASFFFIFIL--------MLHLYIKICKIVCRHA------HQIALQQHFltashyvaTKKGVSTLAIILGT 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 327 YVLCWAPFYGFAIVRDF-FPTVFVkekhyltafYVVECIAMSNSMINTVCF 376
Cdd:cd15962  216 FGASWLPFAIYCVVGDHeYPAVYT---------YATLLPATYNSMINPIIY 257
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
164-334 4.87e-04

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 41.70  E-value: 4.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 164 WEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPL-RPRMKYQTATGLIAL-VWVVSILVAIPSAYFT----TE 237
Cdd:cd15969   65 WNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFgDSRMYSITFTKVLSAcVWLIMAFLSLPNIILTngqpTE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 238 TVLVIVKSQEKIFcGQIWPVdqqiyyksYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGF-QTEQIRKRLRCRRKT 316
Cdd:cd15969  145 DNIHDCSKLKSPL-GVKWHT--------AVSYINICIFVAVLVILIVCYISISRYIYKSSKQFIsSSSRTRKHNQSIRVV 215
                        170
                 ....*....|....*...
gi 528968953 317 VLVLMCILTAYVLCWAPF 334
Cdd:cd15969  216 VAVFFVCFLPYHLCRIPF 233
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
180-226 6.03e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 41.44  E-value: 6.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 528968953 180 VSLYVSTNALLAI-AIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSIL 226
Cdd:cd15235   82 IAFGNTDSFLLAVmAYDRYVAICHPLHyaTVMSPKRCLLLVAGSWLLSHL 131
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
108-335 1.03e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 40.55  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMdyyvvRQLSWEHGHVLCAS---------VNYLR 178
Cdd:cd15351   12 LVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETL-----FMLLLEHGVLVCRApmlqhmdnvIDTMI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 179 TVSLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVVSILVAIpsayftteTVLVIVKSQEKIFCgqiwp 256
Cdd:cd15351   87 CSSVVSSLSFLGAIAVDRYITIFYALRYHsiMTLQRAVNAIAGIWLASTVSST--------LFIVYYNSNAVILC----- 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 257 vdqqiyyksyFLFIFGIEFVGPVVTMTLCYARISRELwfKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15351  154 ----------LIVFFLFMLVLMLVLYIHMFILACRHS--QSISSQQRRQCPHQQTASLKGAITLTILLGIFFLCWGPFF 220
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
106-334 1.69e-03

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 40.20  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 106 IMLVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFemdyyvvrqlsWEH--------GHVLCASVNYL 177
Cdd:cd15171   10 VFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSN-LCFLLTLPF-----------WAHaawhggslGNPTCKVLVAL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 178 RTVSLYVST--NALLaiAIDRYLAIVHPLRPRMKYQTAT-GLIA--LVWVVSILVAIPSAYFTTETvlviVKSQE-KIFC 251
Cdd:cd15171   78 SSVGLHSEAlfNVLL--TVQASRVFFHGRLASSARRVAPcGIIAsvLAWLTAFLVTLPEFVFYKPQ----MDSQKsKCAF 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 252 GQ--IWPVDQQIYYKSYFLFIFGIEFVGPVVTMTLCYARISRelwfkavpgfqTEQIRKRLRCRRKTVLVLMCIltaYVL 329
Cdd:cd15171  152 SRphFLPAEETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRK-----------TQRFRERQRDLSKLVFAIMVV---FLL 217

                 ....*
gi 528968953 330 CWAPF 334
Cdd:cd15171  218 MWAPY 222
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
96-376 1.79e-03

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 39.78  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  96 KIVIGMALVGIMLVCgIGNFIFIAALARYKKLRNLTNLLIANLAISDfLVAIVCCPFEMDYYVVR--QLSWEHGHVLCAs 173
Cdd:cd15342    1 YAVVALGLTVSVIVL-LTNLLVIAAIFINRRFHYPIYYLLGNLAAAD-LFAGVAYLFLMFHTGPWtaKLSLYQWFLRQG- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 174 vnyLRTVSLYVSTNALLAIAIDRYLAIVH-PLRPRMKYQTATGLIALVWVVSILVAIPSAYftTETVLVIVKSqekifCG 252
Cdd:cd15342   78 ---LLDTSLTASVANLLAIAVERHQTIFTmQLHSKMSNQRVVILIFGIWMVALILGLIPAM--GWNCLCDLKR-----CS 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 253 QIWPvdqqIYYKSYFLFIFGIEFVGPVVtMTLCYARISreLWFKAVPGFQTEQIRKRLRcRRKTVLVLM----CILTAYV 328
Cdd:cd15342  148 TMAP----LYSRSYLVFWALSNLLTFLI-MVAVYTRIF--IYVRRKSQRMSEHHSSHPR-YRETVLGLMktvvIILGAFV 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528968953 329 LCWAPFYGFAIVRDFFP---TVFVKEKHYLTafyvvecIAMSNSMINTVCF 376
Cdd:cd15342  220 VCWTPGQVVLLLDGLGCescNVLAYEKYFLL-------LAEINSLVNPIVY 263
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
108-252 2.08e-03

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 39.78  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 108 LVCGIGNFIFIAALARYKKLRNLTNLLIANLAISDflvaIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTN 187
Cdd:cd15233   12 IVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLD----IGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGAD 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528968953 188 ALL--AIAIDRYLAIVHPL--RPRMKYQTATGLIALVWVVSILVAIpsayftTETVLVIVKSqekiFCG 252
Cdd:cd15233   88 CFLltAMAYDRYLAICQPLtySVRMSWRVQTALVGISCACAFTNAL------THTVAMSTLK----FCG 146
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
105-333 2.30e-03

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 39.73  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 105 GIMLVCG-IGNFIFIAALARYKKLRNLTNLLI--ANLAISDFLVaIVCCPFEMDYYVvRQLSWEHGHVLCASVNYLRTVS 181
Cdd:cd15147    8 SIIFVLGlIANCYVLWVFARLYPSKKLNEIKIfmVNLTIADLLF-LITLPFWIVYYH-NEGNWILPKFLCNVAGCLFFIN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 182 LYVSTNALLAIAIDRYLAIVHPLRPRMKYQTATGLI--ALVWVVSILVAIPSAYF-TTETVLVIVKSQEKIFCGqIWPVD 258
Cdd:cd15147   86 TYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIisVAIWVIIVASASYFLFMdSTNTVKIDSGNFTRCFEG-YEKDN 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528968953 259 QQIYYKSYFLFIFGIEFVGPVVtmTLCYARISRELWfkavpgFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAP 333
Cdd:cd15147  165 SKPVLIIHFIIIGLFFLVFLLI--LVCNLVIARTLL------SQPVQGQRNAGVKRRALWMVCTVLAVFVICFVP 231
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
137-378 2.83e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 39.39  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 137 NLAISDFLVAIVCCPFEMDYYVVRQ-LSWEHGHVLCASVNylrtvsLYVSTNALLAIAIDRYLAIVHPLRPRMKYQT--A 213
Cdd:cd15163   41 NLVVTDLLVGLSLPTRIVMYYSAGNcLTCSFVHIFSYFVN------MYCSILFLTCICVDRYLAIVQVEASRRWRNPnyA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 214 TGLIALVWVVSILVaipsayftTETVLVIVKSQEKIFCGQIwpvdqqiyyksYFLFIFgiEFVGPVVTMTLCYARIsreL 293
Cdd:cd15163  115 KGICVFIWLFAIVV--------TFSILTTAIKFASCCLSKL-----------FALTVF--EFFLPLLIITFFTIRI---M 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 294 WFKAVPGFQtEQIRKRlrcRRKTVLVLMCILTAYVLCWAPFYGFAIVRDFFPTvfVKEKHYLTAFYVVECIAMSNSMINT 373
Cdd:cd15163  171 CALSRPGLM-HQSRER---RMRAVQLLITVLIIFMICFTPFHVRQVAVAFNPD--IPHHTSLIVYHVTVTLSSLNSCMDP 244

                 ....*..
gi 528968953 374 V--CFVT 378
Cdd:cd15163  245 IvyCFVT 251
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
189-235 3.78e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 39.00  E-value: 3.78e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 528968953 189 LLAIAIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAIPSAYFT 235
Cdd:cd13954   91 LAVMAYDRYVAICHPLHypTIMNKRVCILLAAGSWLIGFLNSLIHTVLI 139
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
181-335 4.22e-03

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 38.61  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 181 SLYVSTNALLAIAIDRYLAIVHPLRPRM--KYQTATGLIALVWVVSILVAIPSAYFTTETVLVI-VK--SQEKIFCGQIW 255
Cdd:cd15151   82 TMYISIILLGLISFDRYLKIVRPFGKSWvqRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPIsVKkcASLKSPLGLKW 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 256 pvDQQIYYKSYFLFIfgiefvGPVVTMTLCYARISRELWFKAVPGFQTEQIRkrlrcRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15151  162 --HEVVNYICQFIFW------GVFALMVLFYTIISKKVYESYKKSRSKDNKA-----SKKTKAKVFIIVAVFFVCFAPFH 228
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
114-335 4.28e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.76  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 114 NFIFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVV--RQLSWEHGHV--LCASVNYLRTVSLYVSTNAL 189
Cdd:cd15354   18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLnnRHLVIEDAFVrhIDNVFDSLICISVVASMCSL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 190 LAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWVvsilvaipsayFTTEtvlvivksqekifCGQIWPvdqqIYYKSYF 267
Cdd:cd15354   98 LAIAVDRYVTIFYALRYHniMTVRRAGIIIACIWT-----------FCTG-------------CGIIFI----LYSESTY 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528968953 268 LFIFGIE-FVGPVVTMTLCYARI-----SRELWFKAVPGFQTeqirKRLRCRRKTVLVLMCILTAYVLCWAPFY 335
Cdd:cd15354  150 VIICLITmFFAMLFLMVSLYIHMfllarTHVKRIAALPGYNS----VRQRTSMKGAVTLTILLGIFIVCWAPFF 219
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
112-376 4.48e-03

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 38.65  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 112 IGNFIFIAALARYKKLRNLTNLLIANLAISDF-LVA---IVCCPFEMDYYVVRqlswehghVLCASVNYLRTVSLYVSTN 187
Cdd:cd14989   16 IGNILILVVNLSFREKMTIPDLYFVNLAVADLiLVAdslIEVFNLNEKYYDIA--------VLCTFMSLFLQINMYSSIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 188 ALLAIAIDRYLAIV-----HPLRPRMKYQTATGLIalvWVVSIlvaipSAYFTTETVLVIVKSQEKIFCGQIWPVDQQIY 262
Cdd:cd14989   88 FLTWMSFDRYIALAkvmksSPLRTMQHARLSCGLI---WMASI-----SATLLPFTAVQAQHTGEVHFCFADVREIQWLE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 263 YKsyflfifgIEFVGPVVTMTLCYARISRELwfkavpgfQTEQIRKRLRCRRKTVL-VLMCILTAYVLCWAP---FYGFA 338
Cdd:cd14989  160 VT--------LGFIIPFSIIGLCYSLIVRVL--------VRAQKHRRLRPRRQKALrMILVVVLVFFICWLPenvFISIQ 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528968953 339 IVRD------FFPTVFvKEKHYLTAfYVVECIAMSNSMINTVCF 376
Cdd:cd14989  224 LLQGtqepseSYDESF-RHNHPLTG-HIVNLAAFSNSCLNPLIY 265
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
92-335 8.58e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 37.97  E-value: 8.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  92 FFAAKIVIGMALVGIMlvcgiGNFIFIAALARYKKLRNLTNLLIANLAISDFLVAiVCCPFEMDYYVVRQLSWEHGHVLC 171
Cdd:cd15353    1 FVSPEVFVTLGIVSLL-----ENILVIAAIAKNKNLHSPMYFFICSLAVADMLVS-VSNGSETVVITLLNGNDTDAQSFT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 172 ASV-NYLRTV---SLYVSTNALLAIAIDRYLAIVHPLRPR--MKYQTATGLIALVWvvsilvaipsAYFTTETVLVIVKS 245
Cdd:cd15353   75 VNIdNVIDSVicsSLLASICSLLSIAVDRYFTIFYALQYHniMTVRRAGVIITCIW----------TACTVSGVLFIIYS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953 246 QEKIFCgqiwpvdqqIYYKSYFLFIFGIEFVGPVVTMTLCYARISRelwFKAVPGfqTEQIRKRlrCRRKTVLVLMCILT 325
Cdd:cd15353  145 DSSVVI---------ICLISMFFTMLALMASLYVHMFLLARLHIKR---IAVLPG--TGPIRQG--ANMKGAITLTILLG 208
                        250
                 ....*....|
gi 528968953 326 AYVLCWAPFY 335
Cdd:cd15353  209 VFVVCWAPFF 218
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
112-243 9.42e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 37.57  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528968953  112 IGNFIFIAALARYKKLRNLTNLLIANLAISDflvaIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLA 191
Cdd:pfam10320   6 FGNVLMIHLTFRKKKLRSKCSILICVQCIAH----LICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLMLM 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 528968953  192 IAIDRYLAIVHPLR----PRMKYQTATGLIALVWVVSILVaipSAYFTTETVLVIV 243
Cdd:pfam10320  82 IGIDRLIAVKFPIFyrllSSSKYLFIQLIFPVIYSSFITV---YGFLQRDDETIIV 134
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
189-229 9.91e-03

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 37.43  E-value: 9.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 528968953 189 LLAI-AIDRYLAIVHPLR--PRMKYQTATGLIALVWVVSILVAI 229
Cdd:cd15225   90 LLAAmAYDRYVAICNPLRytLIMNRRVCLQLVAGSWLSGILVSL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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