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Conserved domains on  [gi|529003252|ref|XP_005223585|]
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trem-like transcript 1 protein isoform X1 [Bos taurus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
23-120 2.08e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252  23 PELLQASVGSSILVQCHYRLQDVKARKVWCQVLPEGCQPLVTSTvnrGVPASSRIFLTDLG-GGLLQVEMLALREEDAGE 101
Cdd:cd05716    4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSE---GVVPGGRISLTDDPdNGVFTVTLNQLRKEDAGW 80
                         90
                 ....*....|....*....
gi 529003252 102 YACVVEGLSGTQTVHRVTL 120
Cdd:cd05716   81 YWCGVGDDGDRGLTVQVKL 99
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
23-120 2.08e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252  23 PELLQASVGSSILVQCHYRLQDVKARKVWCQVLPEGCQPLVTSTvnrGVPASSRIFLTDLG-GGLLQVEMLALREEDAGE 101
Cdd:cd05716    4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSE---GVVPGGRISLTDDPdNGVFTVTLNQLRKEDAGW 80
                         90
                 ....*....|....*....
gi 529003252 102 YACVVEGLSGTQTVHRVTL 120
Cdd:cd05716   81 YWCGVGDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
23-123 1.55e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 429596  Cd Length: 109  Bit Score: 37.44  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252   23 PELLQASVGSSILVQCHYRLQDVKA--RKVWCQvLPEGCQP---LVTSTVNRGVPASSRIF--LTDLGGGLLQVEMLALR 95
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEAstSVYWYR-QPPGKGPtflIAYYSNGSEEGVKKGRFsgRGDPSNGDGSLTIQNLT 81
                          90       100
                  ....*....|....*....|....*...
gi 529003252   96 EEDAGEYACVVEGLSGTQTVHRVTLDVL 123
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
23-120 2.08e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252  23 PELLQASVGSSILVQCHYRLQDVKARKVWCQVLPEGCQPLVTSTvnrGVPASSRIFLTDLG-GGLLQVEMLALREEDAGE 101
Cdd:cd05716    4 PEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSE---GVVPGGRISLTDDPdNGVFTVTLNQLRKEDAGW 80
                         90
                 ....*....|....*....
gi 529003252 102 YACVVEGLSGTQTVHRVTL 120
Cdd:cd05716   81 YWCGVGDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
23-123 1.55e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 429596  Cd Length: 109  Bit Score: 37.44  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252   23 PELLQASVGSSILVQCHYRLQDVKA--RKVWCQvLPEGCQP---LVTSTVNRGVPASSRIF--LTDLGGGLLQVEMLALR 95
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEAstSVYWYR-QPPGKGPtflIAYYSNGSEEGVKKGRFsgRGDPSNGDGSLTIQNLT 81
                          90       100
                  ....*....|....*....|....*...
gi 529003252   96 EEDAGEYACVVEGLSGTQTVHRVTLDVL 123
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
Ig_Sema3 cd05871
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed ...
53-125 1.79e-03

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.


Pssm-ID: 409455  Cd Length: 92  Bit Score: 36.94  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529003252  53 QVLPEGCQPLVTSTVNRG-------VPASSRIFLTDlgGGLLqveMLALREEDAGEYACVVEGLSGTQTVHRVTLDVLPA 125
Cdd:cd05871   18 ECLPKSPQATVKWLFQRGgdqrkeeVKSEERLIVTD--RGLL---LRSLQRSDAGVYTCQAVEHGFSQTLVKIRLHVIEP 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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