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Conserved domains on  [gi|543832|sp|Q02013|]
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RecName: Full=Aquaporin-1; Short=AQP-1; AltName: Full=Aquaporin-CHIP; AltName: Full=Delayed early response protein 2; Short=DER2; AltName: Full=Water channel protein for red blood cells and kidney proximal tubule

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.91e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 289.99  E-value: 1.91e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832       4 EIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQtlVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLA--VSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      84 LLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543832     164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.91e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 289.99  E-value: 1.91e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832       4 EIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQtlVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLA--VSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      84 LLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543832     164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-227 5.23e-86

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 255.69  E-value: 5.23e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      16 AEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAV 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      96 MYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAH-GVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSAPLAIG 173
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASaGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 543832     174 LSVALGHLLAIDYTGCGINPARSFGSAVLTR--NFSNHWIFWVGPFIGGALAVLIY 227
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-230 3.81e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 243.70  E-value: 3.81e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLG----IALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    92 LRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRN---------DLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRR 162
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543832   163 -DLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFS---NHWIFWVGPFIGGALAVLIYDFI 230
Cdd:cd00333 157 pPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-232 9.94e-55

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.47  E-value: 9.94e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    10 FWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVqdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 89
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLG-----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    90 SILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDL--------AHGVNSGQGLGIEIIGTLQLVLCVLATTDrRR 161
Cdd:COG0580  77 PWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKlgvfatspAIGYSLGAAFLTEIIGTFVLVFVILGITD-KR 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543832   162 RDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVL------TRNFSNHWIFWVGPFIGGALAVLIYDFILA 232
Cdd:COG0580 156 AAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-230 3.31e-45

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 152.63  E-value: 3.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSL--AFGLSIATlaqSVG-HISGAHLNPAVTLGLLLSCQ 88
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALahAFALFVAV---SVGaNISGGHVNPAVTFGAFIGGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     89 ISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGrndLAHGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGS 167
Cdd:PLN00027  98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFS---LSSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543832    168 APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00027 175 APIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.91e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 289.99  E-value: 1.91e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832       4 EIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQtlVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLA--VSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      84 LLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543832     164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-227 5.23e-86

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 255.69  E-value: 5.23e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      16 AEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAV 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      96 MYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAH-GVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSAPLAIG 173
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASaGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 543832     174 LSVALGHLLAIDYTGCGINPARSFGSAVLTR--NFSNHWIFWVGPFIGGALAVLIY 227
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-230 3.81e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 243.70  E-value: 3.81e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLG----IALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    92 LRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRN---------DLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRR 162
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543832   163 -DLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFS---NHWIFWVGPFIGGALAVLIYDFI 230
Cdd:cd00333 157 pPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-232 9.94e-55

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.47  E-value: 9.94e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    10 FWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVqdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 89
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLG-----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    90 SILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDL--------AHGVNSGQGLGIEIIGTLQLVLCVLATTDrRR 161
Cdd:COG0580  77 PWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKlgvfatspAIGYSLGAAFLTEIIGTFVLVFVILGITD-KR 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543832   162 RDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVL------TRNFSNHWIFWVGPFIGGALAVLIYDFILA 232
Cdd:COG0580 156 AAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-230 3.31e-45

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 152.63  E-value: 3.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSL--AFGLSIATlaqSVG-HISGAHLNPAVTLGLLLSCQ 88
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALahAFALFVAV---SVGaNISGGHVNPAVTFGAFIGGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     89 ISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGrndLAHGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGS 167
Cdd:PLN00027  98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFS---LSSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543832    168 APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00027 175 APIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-227 3.33e-44

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 150.09  E-value: 3.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     92 LRAVMYIIAQCVGAIVATAILSGITSSlvdNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGSAPL 170
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNG---ESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAaDPKKGSLGTIAPI 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 543832    171 AIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 12-235 1.42e-39

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 137.41  E-value: 1.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSA-LGFNYPlernqTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQIS 90
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAvLAAAFP-----ELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     91 ILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLA---HGVNSGQG------LGIEIIGTLQLVLCVLATTDRRR 161
Cdd:PRK05420  78 AKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFAsngYGEHSPGGysllaaLVCEVVLTAFFLLVILGATDKRA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 543832    162 RdlGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNF--SNHWIFWVGPFIGGALAVLIYDFILAPRS 235
Cdd:PRK05420 158 P--AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-240 2.36e-32

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 119.24  E-value: 2.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     92 LRAVMYIIAQCVGAIVATAILSGITsslVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLA 171
Cdd:PLN00167 103 PTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLA 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 543832    172 IGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTD 240
Cdd:PLN00167 180 IGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFPTQDDRGS 248
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 8-233 6.78e-26

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 102.90  E-value: 6.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832      8 KLFWRAVVAEFLAMtlFVFISIGSALGFNYPLERNQTlvqDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSC 87
Cdd:PTZ00016  47 RPNVREYVAEFLGT--FVLLFFGEGVVATTHTVGNNG---DYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     88 QISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGlGI---------------EIIGTLQLVLC 152
Cdd:PTZ00016 122 KFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMANGFA-GVfatypregnfyaifsELILTAILLLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    153 VLATTDRRRRDLGGSAPLAIGLSV-ALGHLLAIDyTGCGINPARSFGSAVLT------RNFSNH----WIFWVGPFIGGA 221
Cdd:PTZ00016 201 ILAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPRLFSailwgsEVFTKDnyyfWVPLVAPFVGAV 279

                        250
                 ....*....|..
gi 543832    222 LAVLIYDFILAP 233
Cdd:PTZ00016 280 LGMFLYDKFIPP 291
PLN00184 PLN00184
aquaporin NIP1; Provisional
 10-230 3.03e-22

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 93.16  E-value: 3.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     10 FWRAVVAEFLAMTLFVFISIgSALGFNYPLERNQTLVqdnvKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 89
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGC-ASVVVNMQNDNVVTLP----GIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRF 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     90 SILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVN-SG---QGLGIEIIGTLQLVLcVLATTDRRRRDLG 165
Cdd:PLN00184 128 PLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSpVGsdlQAFVMEFIVTFYLMF-IISGVATDNRAIG 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543832    166 GSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00184 207 ELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 52-230 3.12e-21

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 90.35  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     52 VSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAh 131
Cdd:PLN00182  78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLMFNVTPEAFFGTTPTD- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    132 gvNSGQGLGIEIIGT--LQLVLCVLATTDRRRRDLGGsapLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNH 209
Cdd:PLN00182 157 --SSGQALVAEIIISflLMFVISGVATDSRAVGELAG---IAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI 231

                        170       180
                 ....*....|....*....|.
gi 543832    210 WIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00182 232 WVYIVGPFVGIIAGGFVYNLI 252
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 57-230 7.00e-21

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 89.15  E-value: 7.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     57 GLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATaiLSGITSSLVDNSLGRNDLAHGVNSg 136
Cdd:PLN00183  86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLAT--YVGVSVYGVKADLMTTKPAQGCSS- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832    137 qGLGIEIIGTLQLVLCVLATTDrRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGP 216
Cdd:PLN00183 163 -AFWVEFIATFIVMFLAASLTS-QPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAP 240

                        170
                 ....*....|....
gi 543832    217 FIGGALAVLIYDFI 230
Cdd:PLN00183 241 TIGAVAGALMFHLL 254
PLN00026 PLN00026
aquaporin NIP; Provisional
 12-227 4.47e-19

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 84.53  E-value: 4.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     12 RAVVAEFLAMTLFVFISIGSALgFNYPLERNQTLVQDnvkvSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00026  72 RKLGAEFVGTFILIFAATAGPI-VNQKYDGAETLIGN----AACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543832     92 LRAVMYIIAQCVGAIVATAILSGITSSLVDNSLgrndLAHGVNSGQGLGIEIIGTLQLVLCVLAT-TDRRRrdLGGSAPL 170
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGV----TVPSVSTGQAFALEFIITFNLLFVVTAVaTDTRA--VGELAGI 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 543832    171 AIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTY 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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