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Conserved domains on  [gi|544349|sp|P35376|]
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RecName: Full=Follicle-stimulating hormone receptor; Short=FSH-R; AltName: Full=Follitropin receptor; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
363-637 0e+00

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


:

Pssm-ID: 320482  Cd Length: 275  Bit Score: 526.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGC 442
Cdd:cd15360   1 NILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd15360  81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 602
Cdd:cd15360 161 ESPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLI 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   603 TVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15360 241 TVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
GnHR_trans pfam12369
Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, ...
282-349 1.43e-36

Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00560, pfam00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.


:

Pssm-ID: 432511  Cd Length: 68  Bit Score: 131.10  E-value: 1.43e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349     282 RRQTSDLHPICNKSILRQEVDDMTQARGQRVSLAEDDEPSYAKGFDVMYSEFDYDLCNEVVDVTCSPE 349
Cdd:pfam12369   1 RRQISELHPICNKSSLRQDLDDLTQARGHRRSLEEDYISSYSKEFDMTENEFDYDLCNEVVDVACSPK 68
LRR_8 pfam13855
Leucine rich repeat;
72-132 8.25e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349      72 LEKIEISQNDvLEVIEANVFSNLPKLHEIRIEKaNNLLYIDPDAFQNLPNLRYLLISNTGI 132
Cdd:pfam13855   3 LRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSN-NLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
17-50 4.74e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544349       17 GCHHRlCHCSNGVFLCQESKVTEIPSDLPRDAVE 50
Cdd:smart00013   1 ACPAP-CNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
72-240 1.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 44.57  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    72 LEKIEISQNDVLEVIEAnvFSNLPKLHEIRIekANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAVHKIQSLQKVLLD- 150
Cdd:COG4886 211 LEELDLSNNSIIELLSS--LSNLKNLSGLEL--SNNKLEDLPESIGNLSNLETLDLSNNQISSISSLGSLTNLRELDLSg 286
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   151 ----------IQDNINIHTVERNSFMGLSFE--SMTVWLSK----NGIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVF 214
Cdd:COG4886 287 nslsnalpliALLLLLLELLLNLLLTLKALElkLNSILLNNnilsNGETSSPEALSILESLNNLWTLDNALDESNLNRYI 366
                       170       180
                ....*....|....*....|....*.
gi 544349   215 QGAsgPVILDISRTRIRSLPSYGLEN 240
Cdd:COG4886 367 VKN--PNAIGSLLDLVKKHVNQLLEK 390
 
Name Accession Description Interval E-value
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
363-637 0e+00

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 526.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGC 442
Cdd:cd15360   1 NILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd15360  81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 602
Cdd:cd15360 161 ESPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLI 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   603 TVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15360 241 TVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
379-626 3.73e-47

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 167.48  E-value: 3.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     379 GNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteYHNYAIDWQTG-AGCDAAGFFTVFASELSV 457
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLV-------YYLLHGDWPFGsALCKLVGALFYVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     458 YTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKV-------SICLPMDIDSPLSQLY 530
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVPegnvtvcFIDFPEVLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     531 VMSLLVLnVLAFVVICGCYTHIYLTVRNPNITSSS------SDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-- 602
Cdd:pfam00001 154 LSSVLGF-LLPLLVILVCYTRIIRTLRKSASKQKSeertqrRERKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCEls 232
                         250       260
                  ....*....|....*....|....*
gi 544349     603 -TVSKSKILLVLFYPINSCANPFLY 626
Cdd:pfam00001 233 rLLDKALSITLWLAYVNSCLNPIIY 257
GnHR_trans pfam12369
Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, ...
282-349 1.43e-36

Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00560, pfam00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.


Pssm-ID: 432511  Cd Length: 68  Bit Score: 131.10  E-value: 1.43e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349     282 RRQTSDLHPICNKSILRQEVDDMTQARGQRVSLAEDDEPSYAKGFDVMYSEFDYDLCNEVVDVTCSPE 349
Cdd:pfam12369   1 RRQISELHPICNKSSLRQDLDDLTQARGHRRSLEEDYISSYSKEFDMTENEFDYDLCNEVVDVACSPK 68
LRR_8 pfam13855
Leucine rich repeat;
72-132 8.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349      72 LEKIEISQNDvLEVIEANVFSNLPKLHEIRIEKaNNLLYIDPDAFQNLPNLRYLLISNTGI 132
Cdd:pfam13855   3 LRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSN-NLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
17-50 4.74e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544349       17 GCHHRlCHCSNGVFLCQESKVTEIPSDLPRDAVE 50
Cdd:smart00013   1 ACPAP-CNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
17-45 7.44e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 7.44e-05
                          10        20
                  ....*....|....*....|....*....
gi 544349      17 GCHHRlCHCSNGVFLCQESKVTEIPSDLP 45
Cdd:pfam01462   1 ACPVP-CHCSATVVNCSDRGLTAVPRDLP 28
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
351-639 1.13e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 44.77  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    351 DAFNPCEDIMGDD----ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMcNLAFADLcigiylLLIASVDVHTk 426
Cdd:PHA03087  25 EDYADCDLNIGYDtnstILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLL-NLAVSDL------LFVMTLPFQI- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    427 teYHNYAIDWQTGA-GCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPI 505
Cdd:PHA03087  97 --YYYILFQWSFGEfACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISI-IETTPI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    506 FGISSYMKV---SICLPM-DIDSPLSQLYVMslLVLNVLAFVV----ICGCYTHIYLTVRNPNITSSSsdtKIAKRMAML 577
Cdd:PHA03087 174 LFVYTTKKDhetLICCMFyNNKTMNWKLFIN--FEINIIGMLIpltiLLYCYSKILITLKGINKSKKN---KKAIKLVLI 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544349    578 IFTDF-LCMAP--ISFFAISA-SLKVPLITVSKSKILLVLFYP-----INSCANPFLYAI----FTKNFRRDFFI 639
Cdd:PHA03087 249 IVILFvIFWLPfnVSVFVYSLhILHFKSGCKAVKYIQYALHVTeiislSHCCINPLIYAFvsefFNKHKKKSLKL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-240 1.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 44.57  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    72 LEKIEISQNDVLEVIEAnvFSNLPKLHEIRIekANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAVHKIQSLQKVLLD- 150
Cdd:COG4886 211 LEELDLSNNSIIELLSS--LSNLKNLSGLEL--SNNKLEDLPESIGNLSNLETLDLSNNQISSISSLGSLTNLRELDLSg 286
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   151 ----------IQDNINIHTVERNSFMGLSFE--SMTVWLSK----NGIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVF 214
Cdd:COG4886 287 nslsnalpliALLLLLLELLLNLLLTLKALElkLNSILLNNnilsNGETSSPEALSILESLNNLWTLDNALDESNLNRYI 366
                       170       180
                ....*....|....*....|....*.
gi 544349   215 QGAsgPVILDISRTRIRSLPSYGLEN 240
Cdd:COG4886 367 VKN--PNAIGSLLDLVKKHVNQLLEK 390
LRR_5 pfam13306
Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This ...
57-194 5.99e-04

Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 433104 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349      57 KLRVIPKGAFSGFGDLEKIEISQNdvLEVIEANVFSNLpKLHEIRIEkaNNLLYIDPDAFQNLPNLRYLLISNtgikhlp 136
Cdd:pfam13306  21 SLTSIGEYAFSNCTSLKSITLPSS--LTSIGSYAFYNC-SLTSITIP--SSLTSIGEYAFSNCSNLKSITLPS------- 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349     137 avhkiqslqkvlldiqdniNIHTVERNSFMGLSFESMTVWlskNGIQEIHNCAFNGTQ 194
Cdd:pfam13306  89 -------------------NLTSIGSYAFSNCSLKSITIP---SSVTTIGSYAFSNCS 124
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
113-258 3.09e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     113 PDAFQNLPN-LRYLLISNTGIKHLPAVHKIQSLQKvlLDIQDNinihTVER-----NSFMGLsfESMTVWLSKNgIQEIH 186
Cdd:PLN03210  581 PEGFDYLPPkLRLLRWDKYPLRCMPSNFRPENLVK--LQMQGS----KLEKlwdgvHSLTGL--RNIDLRGSKN-LKEIP 651
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349     187 NCAFnGTQLDELNLSDNSNLEELPNDVfQGASGPVILDISR-TRIRSLPS-YGLENLKKLRAKSTYRLKKLPSL 258
Cdd:PLN03210  652 DLSM-ATNLETLKLSDCSSLVELPSSI-QYLNKLEDLDMSRcENLEILPTgINLKSLYRLNLSGCSRLKSFPDI 723
 
Name Accession Description Interval E-value
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
363-637 0e+00

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 526.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGC 442
Cdd:cd15360   1 NILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd15360  81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 602
Cdd:cd15360 161 ESPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLI 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   603 TVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15360 241 TVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
365-637 5.55e-169

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 484.80  E-value: 5.55e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCDA 444
Cdd:cd15136   3 LRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGCKT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDS 524
Cdd:cd15136  83 AGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFETET 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITV 604
Cdd:cd15136 163 PVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLPLISV 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 544349   605 SKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15136 243 SNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
363-637 3.00e-163

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 470.12  E-value: 3.00e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGC 442
Cdd:cd15359   1 DFLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd15359  81 STAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI 602
Cdd:cd15359 161 ETLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLI 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   603 TVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15359 241 TVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
365-636 6.32e-157

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 453.98  E-value: 6.32e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCDA 444
Cdd:cd15964   3 LRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCNT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDS 524
Cdd:cd15964  83 AGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTET 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITV 604
Cdd:cd15964 163 PLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITV 242
                       250       260       270
                ....*....|....*....|....*....|..
gi 544349   605 SKSKILLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15964 243 SNSKILLVLFYPLNSCANPFLYAIFTKAFRRD 274
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
363-637 9.43e-90

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 281.82  E-value: 9.43e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKL-TVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAG 441
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKkKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLEcKVQLRHAASIMLVGWIFAFAVALFPIFGISS-------YMKV 514
Cdd:cd14980  81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINqpgdnrlYGYS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   515 SICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNIT----SSSSDTKIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd14980 160 SICMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSarrsSSKRDKRIAIRLALILITDLICWLPYYI 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14980 240 VIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
364-635 8.46e-63

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 210.52  E-value: 8.46e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWLCT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISS----YMKVSICLP 519
Cdd:cd15137  82 FAGFLATLSSEVSVLILTLITLDRFICIVFPFS-GRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYfgnfYGRSGVCLP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDI--DSPLSQLYVMSL-LVLNVLAFVVICGCYTHIYLTVR----NPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd15137 161 LHItdERPAGWEYSVFVfLGLNFLAFVFILLSYIAMFISIRrtrkAAASRKSKRDMAVAKRFFLIVLTDFLCWIPIIVIG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   593 ISASLKVPlitVSKSKI--LLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15137 241 ILALSGVP---IPGEVYawVAVFVLPINSALNPILYTLSTPKFRK 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
379-626 3.73e-47

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 167.48  E-value: 3.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     379 GNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteYHNYAIDWQTG-AGCDAAGFFTVFASELSV 457
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLV-------YYLLHGDWPFGsALCKLVGALFYVNGYASI 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     458 YTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKV-------SICLPMDIDSPLSQLY 530
Cdd:pfam00001  74 LLLTAISIDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVPegnvtvcFIDFPEVLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     531 VMSLLVLnVLAFVVICGCYTHIYLTVRNPNITSSS------SDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-- 602
Cdd:pfam00001 154 LSSVLGF-LLPLLVILVCYTRIIRTLRKSASKQKSeertqrRERKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCEls 232
                         250       260
                  ....*....|....*....|....*
gi 544349     603 -TVSKSKILLVLFYPINSCANPFLY 626
Cdd:pfam00001 233 rLLDKALSITLWLAYVNSCLNPIIY 257
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
365-637 1.60e-43

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 158.09  E-value: 1.60e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCDA 444
Cdd:cd15138   3 IRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGCKV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDS 524
Cdd:cd15138  83 AGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPTGE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNItSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITV 604
Cdd:cd15138 163 PPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDL-EENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISISP 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 544349   605 SKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15138 242 EIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
367-629 9.78e-43

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 155.91  E-value: 9.78e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEyhnyaidWQTGAGCDAAG 446
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLG 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYM--KVSICLPMDIDS 524
Cdd:cd00637  76 FLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDygGYCCCCLCWPDL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRN------------PNITSSSSDTKIAKRMAMLIFTDFLCMAPIS-F 590
Cdd:cd00637 156 TLSKAYTIFLFVLLfLLPLLVIIVCYVRIFRKLRRhrrrirssssnsSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFiL 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIF 629
Cdd:cd00637 236 LLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
364-637 2.46e-38

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 143.46  E-value: 2.46e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15361   2 MIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGCK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd15361  82 VAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPTG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIaKRMAMLIFTDFLCMAPISFFAISASLKVPLIT 603
Cdd:cd15361 162 ETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMI-KHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   604 VSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15361 241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
364-636 6.78e-38

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 142.29  E-value: 6.78e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15363   2 LIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGCQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd15363  82 ITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPFG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNItSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLIT 603
Cdd:cd15363 162 EPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGEL-ENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240
                       250       260       270
                ....*....|....*....|....*....|...
gi 544349   604 VSKSKILLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15363 241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKED 273
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
364-635 3.17e-37

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 140.42  E-value: 3.17e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGI--YLLLIASvdvhtkteyhNYAIDWQTG-A 440
Cdd:cd14969   2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVvgYPLSFYS----------NLSGRWSFGdP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 GCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYM----KVSI 516
Cdd:cd14969  72 GCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLK-AFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVpeggGTSC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNI-------TSSSSDTKIAKR----MAMLIFTDFL- 583
Cdd:cd14969 151 SVDWYSKDPNSLSYIVSLFVFCfFLPLAIIIFCYYKIYRTLRKMSKraarrknSAITKRTKKAEKkvakMVLVMIVAFLi 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   584 CMAPISFFAISASLKVPlitVSKSKILLV---LFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd14969 231 AWTPYAVVSLYVSFGGE---STIPPLLATipaLFAKSSTIYNPIIYVFMNKQFRR 282
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
364-637 4.50e-37

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 139.93  E-value: 4.50e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15362   2 VVRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGCR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd15362  82 ATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSPLP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 S--PLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNItSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPL 601
Cdd:cd15362 162 DgkPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEF-DAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLFP 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   602 IT--VSKSKILLVLfyPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15362 241 ISpeVIKSVLLVVL--PLPACLNPLLYLLFNPHFRDDL 276
GnHR_trans pfam12369
Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, ...
282-349 1.43e-36

Gonadotropin hormone receptor transmembrane region; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00560, pfam00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.


Pssm-ID: 432511  Cd Length: 68  Bit Score: 131.10  E-value: 1.43e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349     282 RRQTSDLHPICNKSILRQEVDDMTQARGQRVSLAEDDEPSYAKGFDVMYSEFDYDLCNEVVDVTCSPE 349
Cdd:pfam12369   1 RRQISELHPICNKSSLRQDLDDLTQARGHRRSLEEDYISSYSKEFDMTENEFDYDLCNEVVDVACSPK 68
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
367-637 1.25e-30

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 121.13  E-value: 1.25e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYaidWQTGAG-CDAA 445
Cdd:cd14967   4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVY-----TLLGY---WPFGPVlCRFW 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG----ISSYMKVSICLPMd 521
Cdd:cd14967  76 IALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGwrdeTQPSVVDCECEFT- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 idspLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRnpnitsssSDTKIAKRMAMLIFTDFLCMAP-ISFFAISASLKV 599
Cdd:cd14967 155 ----PNKIYVLVSSVISfFIPLLIMIVLYARIFRVAR--------RELKAAKTLAIIVGAFLLCWLPfFIIYLVSAFCPP 222
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   600 PLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14967 223 DCVPPILYAVFFWLGY-LNSALNPIIYALFNRDFRRAF 259
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
364-634 1.33e-28

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 116.12  E-value: 1.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVI--LITSQYKLTVPRFLmcNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAG 441
Cdd:cd15965   2 VQRVFVWVVSAVTCFGNIFVICMrpYIRSENKLHAMSII--SLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLeCKVQLRHAASIMLVGWIFAFAVALFPI----FGISSYMKVSIC 517
Cdd:cd15965  80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRC-LTPGKCRTITILILIWIIGFIIAFIPLsnkeFFRNYYGTNGVC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLS---QLY-VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSS------SDTKIAKRMAMLIFTDFLCMAP 587
Cdd:cd15965 159 FPLHSEQPEStgaQIYsVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEisnhikKEMTLAKRFFFIVFTDALCWIP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   588 ISFFAISASLKVPlITVSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15965 239 IFILKLLSLLQVE-IPGTISSWVVIFILPINSALNPILYTLTTRPFK 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
374-637 2.61e-26

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 109.61  E-value: 2.61e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtkteyhNYAIDWQTGAG-CDAAGFF---T 449
Cdd:cd14993  12 LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLE--------NVYRPWVFGEVlCKAVPYLqgvS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFAselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAV--------ALFPIFGISSYMK-VSICLPM 520
Cdd:cd14993  84 VSA---SVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIImlpllvvyELEEIISSEPGTItIYICTED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLY-VMSLLVLNVLAFVVICGCYTHIYLTV--RNPNITSSSSDT-----------KIAKRMAMLIFTDFLCMA 586
Cdd:cd14993 161 WPSPELRKAYnVALFVVLYVLPLLIISVAYSLIGRRLwrRKPPGDRGSANStssrrilrskkKVARMLIVVVVLFALSWL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   587 PisFFAISASLKVPLITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd14993 241 P--YYVLSILLDFGPLSSEESDENFLLILPFaqllgysNSAINPIIYCFMSKKFRRGF 296
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
364-634 1.99e-25

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 106.79  E-value: 1.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15966   2 ILRVFVWVMAFITCFGNLFVIGMRSFIRAENKTHAMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPI-----FGiSSYMKVSICL 518
Cdd:cd15966  82 IIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFS-NIRPGKCQTLIILISIWLVGFIIAVIPFwnedfFG-NYYGKNGVCF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDID---SPLSQLYVMSL-LVLNVLAFVVICGCYTHIYLTVRNPNITSSS------SDTKIAKRMAMLIFTDFLCMAPI 588
Cdd:cd15966 160 PLHSDqteKIGAKGYSTGIfLGLNLLAFIIIVFSYSSMFCSIQKTGLQTTEvrshihRDVAVANRFFFIVFSDAICWIPI 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   589 SFFAISASLKVPLITVSKSKIlLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15966 240 FLLKILSLFQVEIPGTITSWI-VIFILPINSALNPILYTLTTSFFK 284
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
367-636 4.15e-23

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 99.66  E-value: 4.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGI--YLLLIASvdvhtkteyhNYAIDWQTG-AGCD 443
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVfgYPLAIIS----------AFAHRWLFGdIGCV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAmQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd15074  75 FYGFCGFLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSID 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 ------SPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRN----------PNITSSSSDTKIAKrMAMLIFTDFLCM- 585
Cdd:cd15074 154 wtgasaSVGGMSYIISIFIFCyLLPVLIIVFSYVKIIRKVKSsrkrvagfdsRSKRQHKIERKVTK-VAVLICAGFLIAw 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   586 ---APISFFAI-SASLKVPLITvsksKILLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15074 233 tpyAVVSMWSAfGSPDSVPILA----SILPALFAKSSCMYNPIIYLLFSSKFRQD 283
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
367-637 1.22e-21

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 95.04  E-value: 1.22e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWF--ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTkteYHNYAIDWQTGAG-CD 443
Cdd:cd15001   2 VIIVYviTFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADL-----LLLVFCVPLKT---AEYFSPTWSLGAFlCK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVA---LFPI----FGISSYMKVSI 516
Cdd:cd15001  74 AVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAspvLFGQglvrYESENGVTVYH 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVM-SLLVLNVLAFVVICGCYTHiyltvrnpnitssssDTKIA--KRMAMLIFTDFLCMAPI----- 588
Cdd:cd15001 154 CQKAWPSTLYSRLYVVyLAIVIFFIPLIVMTFAYAR---------------DTRKQviKMLISVVVLFAVCWGPLlidnl 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   589 --SFFAISASlkvPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15001 219 lvSFDVISTL---HTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
364-637 1.38e-21

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 95.55  E-value: 1.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliasvdvhtkteyhnyAIDWQTGAG-- 441
Cdd:cd15393   2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLF------------------SIPFQFQAAll 63
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 ---------CDAAGFFTVFASELSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAVAL-FPIF----- 506
Cdd:cd15393  64 qrwvlprfmCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHP--LKARCSKKSAKIIILIIWILALLVALpVALAlrvee 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   507 --GISSYMKVSICLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDT----------KIAKR 573
Cdd:cd15393 142 ltDKTNNGVKPFCLPVGPSDDWWKIYNLYLVCVQyFVPLVIICYAYTRIAVKIWGTKAPGNAQDVrddeilknkkKVIKM 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   574 MAMLIFTDFLCMAPISFFAISASLKvPLITVSKSkILLVLFYP-----INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15393 222 LIIVVALFALCWLPLQTYNLLNEIK-PEINKYKY-INIIWFCShwlamSNSCYNPFIYGLYNEKFKREF 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
371-637 1.38e-20

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 92.67  E-value: 1.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVhtkTEYHNYAIDWQTGAG-CDAAGFF- 448
Cdd:cd15203   9 LIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDL-----LLCLVSLPF---TLIYTLTKNWPFGSIlCKLVPSLq 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 --TVFASELsvyTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAVALfPIF---------GISSYMKVSIC 517
Cdd:cd15203  81 gvSIFVSTL---TLTAIAIDRYQLIVYP--TRPRMSKRHALLIIALIWILSLLLSL-PLAifqelsdvpIEILPYCGYFC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKR-----------MAMLI---FTDF 582
Cdd:cd15203 155 TESWPSSSSRLIYTISVLVLQfVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRrrselrrkrrtNRLLIamvVVFA 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   583 LCMAPISFFAISASLKVPLITVSKSKILLVLFYPI----NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15203 235 VCWLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHLiamsSACVNPLLYGWLNDNFRKEF 293
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
364-637 5.59e-20

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 90.64  E-value: 5.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliaSVDVHTKTEYHNYaidWQTGAG-C 442
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLF-----NTPFTFVRAVNNT---WIFGLFmC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAVAL-------FPIFGISSYMKVS 515
Cdd:cd15202  74 HFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHP--LKPRISKTKAKFIIAVIWTLALAFALphaicskLETFKYSEDIVRS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLVLNVLAFV---VICGCYTHIYLTV---RNPNITSSSSDTKIAK------RMAMLIFTDF- 582
Cdd:cd15202 152 LCLEDWPERADLFWKYYDLALFILQYFLpllVISFAYARVGIKLwasNMPGDATTERYFALRRkkkkviKMLMVVVVLFa 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   583 LCMAPISFFAISASLKVPlitvSKSKILLVLFYPI------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15202 232 LCWLPFNIYVLLLSSKPD----YLIKTINAVYFAFhwlamsSTCYNPFIYCWLNERFRIEF 288
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
367-637 1.18e-19

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 89.73  E-value: 1.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIW----FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtKTEYHNYaidWQTGAG- 441
Cdd:cd15392   1 VIIIlmysTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFI----ALLILQY---WPFGEFm 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAL-FPIF-GISSYMKVS---- 515
Cdd:cd15392  74 CPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWPLRP--RMTKRQALLLIAVIWIFALATALpIAITsRLFEDSNAScgqy 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTV---RNPNITSSSSD-------TKIAKRMAM--LIFTdf 582
Cdd:cd15392 152 ICTESWPSDTNRYIYSLVLMILQyFVPLAVLVFTYTRIGIVVwakRTPGEAENNRDqrmaeskRKLVKMMITvvAIFA-- 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   583 LCMAPISFFAIsaslkVPLI--TVSKSKILLVLFYPI------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15392 230 LCWLPLNILNL-----VGDHdeSIYSWPYIPYLWLAAhwlamsHCCYNPFIYCWMNAKFRNGF 287
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
364-628 3.88e-19

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 88.40  E-value: 3.88e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYL-LLIasvdvhtkteYHNYAIDWQTGA-G 441
Cdd:cd15079   2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMpIFI----------YNSFYEGWALGPlG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVgWIFAFAVALFP-IFGISSYMK---VSIC 517
Cdd:cd15079  72 CQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFI-WLYALPWALLPlLFGWGRYVPegfLTSC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 ----LPMDIDsplSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRN-----------PNITSSSSDT---------KIAK 572
Cdd:cd15079 151 sfdyLTRDWN---TRSFVATIFVFAyVIPLIIIIYCYSFIVKAVFAhekalreqakkMNVVSLRSNAdankqsaeiRIAK 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   573 RMAMLIFTDFLCMAP---ISFFAISA--SLKVPLITvskskILLVLFYPINSCANPFLYAI 628
Cdd:cd15079 228 VALTNVFLWFIAWTPyavVALIGAFGnqSLLTPLVS-----MIPALFAKTAACYNPIVYAI 283
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
364-637 6.60e-19

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 87.35  E-value: 6.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVL-VILITSQYKlTVPRFLMCNLAFADLCIGIYL-LLIASVDVHTkteyhnyaidWQTGA- 440
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIyVILRYSKMK-TVTNIYILNLAVADELFLLGLpFLATSYLLGY----------WPFGEv 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 ------GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFG--ISSY 511
Cdd:cd14970  71 mckivlSVDAYNMFT------SIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLpVIIFArtLQEE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   512 MKVSICL-----PMDIDSPLSQLYvmSLLVLNVLAFVVICGCYTHIYL---TVRNPNITSSS----SDTKIAKRMAMLIF 579
Cdd:cd14970 145 GGTISCNlqwpdPPDYWGRVFTIY--TFVLGFAVPLLVITVCYSLIIRrlrSSRNLSTSGARekrrARRKVTRLVLVVVA 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   580 TDFLCMAPISFFAI---SASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14970 223 VFVVCWLPFHVFQIvrlLIDPPETLTVVGVFLFCIALSY-ANSCLNPILYAFLDENFRKSF 282
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
364-637 8.37e-19

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 86.64  E-value: 8.37e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdVHTKTEYHNYAIDWqtgagCD 443
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFGRDW-----CD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAlFPifGI-------SSYMKVSI 516
Cdd:cd15067  75 VWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS-FP--AIawwravdPGPSPPNQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDidsplSQLY-VMSLLVLNVLAFVVICGCYTHIYLTvrnpnitsSSSDTKIAKRMAMLIFTDFLCMAPISFFAISA 595
Cdd:cd15067 152 CLFTD-----DSGYlIFSSCVSFYIPLVVMLFTYYRIYRA--------AAKEQKAAKTLGIVMGVFILCWLPFFVTNILI 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   596 SLkVPLITVSKSKILLVLF----YpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15067 219 GF-CPSNCVSNPDILFPLVtwlgY-INSGMNPIIYACSSRDFRRAF 262
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
371-637 9.43e-19

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 86.94  E-value: 9.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiyLLLIASVDvhTKTEYHNYAIDWQTGAG-CDAAGFFT 449
Cdd:cd14982   9 LIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALAD------LLFVLTLP--FRIYYYLNGGWWPFGDFlCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSYMKVSICLPMDIDSPL-- 526
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVpLLLLRSTIAKENNSTTCFEFLSEWla 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 -SQLYVMSLLVLN-VLAFVVICGCYTHIYLTV-RNPNITSSSSDTKIAKRMAMLIFTDFL-CMAPI-SFFAISASLKVPL 601
Cdd:cd14982 161 sAAPIVLIALVVGfLIPLLIILVCYSLIIRALrRRSKQSQKSVRKRKALRMILIVLAVFLvCFLPYhVTRILYLLVRLSF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 544349   602 ITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd14982 241 IADCSARNSLYKAYRItlclaslNSCLDPLIYYFLSKTFRKRL 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
364-637 1.00e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 86.75  E-value: 1.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTGA-GC 442
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPG--------WVFGDfMC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL--FPIFGISSYM--KVSICL 518
Cdd:cd14971  74 KFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAApvLALHRLRNYTpgNRTVCS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLLVLN-VLAFVVICGCY----THIYLTVRNPNITSSS--SDTKIAKRMAMLIFTDFLCMAPISFF 591
Cdd:cd14971 154 EAWPSRAHRRAFALCTFLFGyLLPLLLICVCYaamlRHLWRVAVRPVLSEGSrrAKRKVTRLVLVVVVLFAACWGPIHAI 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   592 AISASLKVPLITVSK--SKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14971 234 LLLVALGPFPLTYATyaLRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
367-637 1.34e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 86.58  E-value: 1.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVdvhtkTEYHNYAIDWQTG-AGCDAA 445
Cdd:cd15096   5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADL---LFVVFCVPF-----TATDYVLPTWPFGdVWCKIV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQlecKVQLR--HAASIMLVG-W--IFAFAVALFPIFGISSYM----KVSI 516
Cdd:cd15096  77 QYLVYVTAYASVYTLVLMSLDRYLAVVHPIT---SMSIRteRNTLIAIVGiWivILVANIPVLFLHGVVSYGfsseAYSY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCY----THIYLTVRNPNITSSSSD--TKIAKRMAMLIFTDF-LCMAPI 588
Cdd:cd15096 154 CTFLTEVGTAAQTFFTSFFLFSyLIPLTLICVLYmlmlRRLRRQKSPGGRRSAESQrgKRRVTRLVVVVVVVFaICWLPI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   589 SFFAISASLKVPLITVSKsKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15096 234 HIILLLKYYGVLPETVLY-VVIQILSNCLaygNSCVNPILYAFLSQNFRKAF 284
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
364-635 1.78e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 86.23  E-value: 1.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVhtkTEYHNYAIDWQTG-AGC 442
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDF-----LMCILNCPL---MVISSFSGRWIFGkTGC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----MKVSICL 518
Cdd:cd15083  74 DMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYvlegLLTSCSF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVR------------NPNITSSS------SDTKIAKRMAMLIF 579
Cdd:cd15083 154 DYLSRDDANRSYVICLLIFGfVLPLLIIIYCYSFIFRAVRrhekamkemakrFSKSELSSpkarrqAEVKTAKIALLLVL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   580 TDFLCMAPisfFAIsaslkVPLITVSKSKILL--------VLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15083 234 LFCLAWTP---YAV-----VALIGQFGYLEVLtplataipAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
371-637 2.85e-18

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 85.80  E-value: 2.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEyhnyaidWQTGAG-CDAAGFFT 449
Cdd:cd14997   9 VIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREP-------WLLGEFmCKLVPFVE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMK--------VSICLpMD 521
Cdd:cd14997  82 LTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS-PVLFITEFKEedfndgtpVAVCR-TP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYV-MSLLVLNVLAFVVICGCYTHI-YLTVRNPNITSSSSDTKIAKRMA-------MLI---FTDFLCMAPIS 589
Cdd:cd14997 160 ADTFWKVAYIlSTIVVFFVVPLAILSGLYSVIcRRLVGHPALESRRADAANRHTLRsrrqvvyMLItvvVLFFVCLLPFR 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   590 FF-------------AISASLKVPLITVSKskillVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14997 240 VVtlwiifapdedlqALGLEGYLNLLVFCR-----VMVY-LNSALNPILYNLMSTKFRSAF 294
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
367-637 5.61e-18

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 84.65  E-value: 5.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGI-YLLLIASVDVHTKTEYHNYAIDWQTGagcdaa 445
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIaFVFTFLSVLLVSLTPSPATWLLRKGS------ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 gFFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKV-SICLPMdiDS 524
Cdd:cd14972  77 -LVLSLLA--SAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDqESCSPL--GP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNI-----------TSSSSDTKIAKRMAMLIFTDFLCMAPISFFAI 593
Cdd:cd14972 152 GLPKSYLVLILVFFFIALVIIVFLYVRIFWCLWRHANaiaarqeaavpAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLV 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   594 SASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14972 232 LDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
367-635 7.16e-18

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 84.68  E-value: 7.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADL----CIGIYLLLIASvdvhtkteYHNYaidWQTG-AG 441
Cdd:cd15337   5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFgfsaVNGFPLKTISS--------FNKK---WIWGkVA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYM----KVSIC 517
Cdd:cd15337  74 CELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVpegfQTSCT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLSQLYVMSLLVLNVLA-FVVICGCYTHIYLTVRN-------------PNITSSS-----SDTKIAKRMAMLI 578
Cdd:cd15337 154 FDYLSRDLNNRLFILGLFIFGFLCpLLIIIFCYVNIIRAVRNhekemtqtaksgmGKDTEKNdarkkAEIRIAKVAIILI 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544349   579 FTDFLCMAP---ISFFAI--SASLKVPLITVskskiLLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15337 234 SLFLLSWTPyavVALLGQfgPAYWITPYVSE-----LPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
371-637 1.21e-17

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 83.92  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYAidWQTGAG-CDAAGFFT 449
Cdd:cd15134   9 IIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDL-----LLLILGLPFELYTIWQQYP--WVFGEVfCKLRAFLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL------------FPIFGISSYMKVSIC 517
Cdd:cd15134  82 EMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqtrivyleYPPTSGEALEESAFC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNI------------TSSSSDTKIAKRMAMLIFTDFLCM 585
Cdd:cd15134 162 AMLNEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLlrrgqrsvsggrRSSQSRRTVLRMLVAVVVAFFICW 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544349   586 APisFFAISaslkvpLITVSKSK-------ILLVLFYP------INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15134 242 AP--FHAQR------LLTVYAKNmtppylfINRILFYIsgvlyyVSSTVNPILYNVMSAKYRQAF 298
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
372-635 1.34e-17

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 83.63  E-value: 1.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCI-GIYLLLIASVDVHTKteyhnyaidWQTG-AGCDAAGFFT 449
Cdd:cd15073  10 AGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVsIIGYPFSAASDLHGS---------WKFGyAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHaMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI-----DS 524
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICR-PDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTInwrknDS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQlYVMSLLVLN-VLAFVVICGCYTHIYLTVR-------NPNITSSSSDTKIAKRMAM-LIFTDFLCMAPISFFAISA 595
Cdd:cd15073 160 SFVS-YTMSVIVVNfIVPLAVMFYCYYNVSRFVKkvlasdcLESVNIDWTDQNDVTKMSViMIVMFLVAWSPYSIVCLWA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 544349   596 SLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15073 239 SFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
374-637 3.93e-17

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 82.34  E-value: 3.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyllLIASVDVHTKTEYhNYAIDWQTG-AGCDAAGFFTVFA 452
Cdd:cd15390  12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADL-------LISAFNTVFNFTY-LLYNDWPFGlFYCKFSNFVAITT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAlFPIFGISSYMKVS--------ICL---PMD 521
Cdd:cd15390  84 VAASVFTLMAISIDRYIAIVHPLRP--RLSRRTTKIAIAVIWLASFLLA-LPQLLYSTTETYYyytgsertVCFiawPDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDTKI----AKR----MAMLIFTDF-LCMAPISFF 591
Cdd:cd15390 161 PNSLQDFVYNIVLFVVTyFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLesvrAKRkvvkMMIVVVVIFaICWLPYHLY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   592 AISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15390 241 FILTYLYPDINSWKYIQQIYLAIYWLamsNSMYNPIIYCWMNKRFRYGF 289
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
372-637 1.82e-16

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 80.17  E-value: 1.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVlVILITSQYKL-TVPRFLMCNLAFADLCIGIYLLLIAsvdVHTKTEYHnyaidWQTGAG-CDAAGFFT 449
Cdd:cd15192  10 IFVVGIFGNSLV-VIVIYCYMKLkTVANIFLLNLALADLCFLITLPLWA---AYTAMEYH-----WPFGNFlCKIASALV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFP------IFGISSYMKvSIClPMDID 523
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAG-VASLPaiihrdVFFIENTNI-TVC-AFHYP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNP-NITSSSS-DTKIAKRMAMLIFTDFLCMAP---ISFFAIS 594
Cdd:cd15192 158 SQNSTLLVGLGLMKNLLGFlipfLIILTCYTLIGKALKKAyEIQRNKPrNDEIFKMIMAVVLFFFFCWIPhqiFTFLDVL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   595 ASLKV------PLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15192 238 IQLKViqdchiADIVDTAMPFTICIAY-FNSCLNPILYGFVGKNFRKKF 285
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
364-637 6.50e-16

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 78.88  E-value: 6.50e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTGAG-C 442
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIP--------YTLTGKWPFGKVfC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd15048  74 KAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTGDC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSP-LSQLYVmsLLVLNVLAFVV----ICGCYTHIYLTVR----------NPNITSSSS---------------DTKIAK 572
Cdd:cd15048 154 EVEfFDHFYF--TFITSVLEFFIpfisVSFFNLLIYLNIRkrsrrrplrsVPILPASQNpsrarsqreqvklrrDRKAAK 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544349   573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15048 232 SLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
364-635 7.15e-16

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 78.26  E-value: 7.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLC--IGIYLLLiasvdvhtkteyHNYAID--WQTG 439
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLfmLGMPFLI------------HQFAIDgqWYFG 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 A-------GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLeCKVQLRHAASIMLVG-WIFAFAVALfPIFGISSY 511
Cdd:cd15088  70 EvmckiitALDANNQFT------STYILTAMSVDRYLAVVHPIRS-TKYRTRFVAKLVNVGlWAASFLSIL-PVWVYSSL 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   512 MK----VSIC---LPMDIDSPLSQLYvmSLLVLNVLAFVVICGCYTHI--YL--TVRNPNITSSSSDTKIAKRMAMLIFT 580
Cdd:cd15088 142 IYfpdgTTFCyvsLPSPDDLYWFTIY--HFILGFAVPLVVITVCYILIlhRLarGVAPGNQSHGSSRTKRVTKMVILIVV 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   581 DF-LCMAPISFFA-ISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15088 220 VFiVCWLPFHVVQlVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
372-637 7.51e-16

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 78.43  E-value: 7.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvHTKTEyhnyaidWQTGAG-CDAAGFFTV 450
Cdd:cd15207  10 IFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVD-NILTG-------WPFGDVmCKLSPLVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMqlECKVQLRHAASIMLVGWIFAFAVALfPI--------FGISSYMKVSICLPMDI 522
Cdd:cd15207  82 VSVAASVFTLVAIAVDRYRAVVHPT--EPKLTNRQAFVIIVAIWVLALAIMI-PQalvlevkeYQFFRGQTVHICVEFWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVL-NVLAFVVICGCYTHIYL------TVRNPNITSSSSDTKIAKRMA---MLIftdflcmAPISFFA 592
Cdd:cd15207 159 SDEYRKAYTTSLFVLcYVAPLLIIAVLYVRIGYrlwfkpVPGGGSASREAQAAVSKKKVRvikMLI-------VVVVLFA 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   593 ISAslkVPL-----------ITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15207 232 LSW---LPLhtvtmlddfgnLSPNQREVLYVYIYPIahwlayfNSCVNPIVYGYFNRNFRKGF 291
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
367-637 1.07e-15

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 77.73  E-value: 1.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNilVLVILITS-QYKLTVPRFLMCNLAFAD-LCIGIYLLLIASVdvhtKTEYHnyaidWQTG-AGCD 443
Cdd:cd14974   5 VLYALIFLLGLPGN--GLVIWVAGfKMKRTVNTVWFLNLALADfLFCLFLPFLIVYI----AMGHH-----WPFGsVLCK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFF---TVFASelsVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFG----ISSYMKVSI 516
Cdd:cd14974  74 LNSFVislNMFAS---VFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSV-PYFVfrdtVTHHNGRSC 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQ-----LYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIakrMAMLIFTDFLCMAPISFF 591
Cdd:cd14974 150 NLTCVEDYDLRRsrhkaLTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRV---LLAVVVAFFLCWLPYHVF 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   592 A---ISASlKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14974 227 AlleLVAA-AGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
366-637 1.36e-15

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 77.82  E-value: 1.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   366 RVLI-WFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTG-AGCD 443
Cdd:cd15195   3 RVLVtWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAV--------WNYTVEWLAGdLMCR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLEckvQLRHAASIML-VGWIFAFAVAL--FPIFGISSYMKVSI---- 516
Cdd:cd15195  75 VMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSAN---QARKRVKIMLtVAWVLSALCSIpqSFIFSVLRKMPEQPgfhq 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQL---YVMSLLVLNVLAFVVICGCYTHIYLTV----RNPNITSSSSDT-----------KIAKRMAMLI 578
Cdd:cd15195 152 CVDFGSAPTKKQErlyYFFTMILSFVIPLIITVTCYLLILFEIskmaKRARDTPISNRRrsrtnslerarMRTLRMTALI 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   579 FTDFL-------CMAPISFFAISASLKVPLITvskSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15195 232 VLTFIvcwgpyyVLGLWYWFDKESIKNLPPAL---SHIMFLLGY-LNPCLHPIIYGVFMKEIRNWI 293
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
363-637 1.83e-15

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 77.42  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIAsvdvhtktEYHNYAIDWQTGAG- 441
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWA--------TYTANQYDWPFGAFl 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIF-----GISSYMKVSI 516
Cdd:cd14985  73 CKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSL-PTFllrslQAIENLNKTA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQ-LYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSS---SDTKIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd14985 152 CIMLYPHEAWHFgLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKngrKRRKSLKIIFALVVAFLVCWLPFHFFK 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   593 ISASLkVPLITVSKSKILLVL---------FYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14985 232 FLDFL-AQLGAIRPCFWELFLdlglpiatcLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
374-635 1.04e-14

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 75.43  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKlTVPR--FLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTG-AGCDAAGFFTV 450
Cdd:cd15382  12 LIAAVGNLTVLLILLRNRRR-KRSRvnILLMHLAIADLLVTFIMMPLEIG--------WAATVAWLAGdFLCRLMLFFRA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLeckVQLRHAASIML-VGWIFAFAVALfP---IFGISSYMKV---SICLPMDid 523
Cdd:cd15382  83 FGLYLSSFVLVCISLDRYFAILKPLRL---SDARRRGRIMLaVAWVISFLCSI-PqsfIFHVESHPCVtwfSQCVTFN-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLA-----FVVICGCYTHIYLTVRN--------------PNITSSSSDTKIAK------RMAMLI 578
Cdd:cd15382 157 FFPSHDHELAYNIFNMITmyalpLIIIVFCYSLILCEISRkskekkedvsekssSVRLRRSSVGLLERarsrtlKMTIVI 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   579 -------FTDFLCMAPISFFAISASLKVPlitvSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15382 237 vlvfiicWTPYFIMSLWYWFDRESASKVD----PRIQKGLFLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
364-637 1.08e-14

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 75.16  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVhtkteYHNYaidWQTGA-GC 442
Cdd:cd14992   2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYV-----VSLS---WEYGHfLC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDI 522
Cdd:cd14992  74 KIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 D----SPLSQLYVMS------LLVLNVLAFVVICGCYTHIYLTV---RNPNITSSSSDT-------KIAKRMAMLIFTDF 582
Cdd:cd14992 154 FccqiPPVDNKTYEKvyflliFVVIFVLPLIVMTLAYARISRELwfrKVPGFSIKEVERkrlkckrRVIKMLVCVVVLFV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544349   583 LCMAPI-SFFAISASLKvpliTVSKSKILLVLFYPI------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd14992 234 ICWLPFhLFFLLRDFFP----LIMKEKHTLQVYYFLhwiamsNSMYNPIIYVTLNNNFRKNF 291
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
371-637 1.66e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 74.58  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyhnYAI--DWQTGAG-CDAAGF 447
Cdd:cd16003   9 FVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFI----------YALhsEWYFGEAyCRFHNF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMqlecKVQLRHAASIMLVG--WIFAFAVAlFP--IFGISSYMKV-SICL---P 519
Cdd:cd16003  79 FPITSVFASIYSMTAIAVDRYMAIIDPL----KPRLSATATKVVIGsiWILAFLLA-FPqcLYSKTKVMPGrTLCFvawP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLVLnVLAFVVICGCYTHIYLTVRNPNITSSSSDT---------KIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd16003 154 GGPDQHFTYHIIVIVLVY-CLPLLVMGITYTIVGITLWGGEIPGDTSDKyheqlrakrKVVKMMIIVVLTFAICWLPYHI 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   591 FAISASLKVPLitvSKSK----ILLVLFYPINSCA--NPFLYAIFTKNFRRDF 637
Cdd:cd16003 233 YFIVTGLYQQL---NRWKyiqqVYLASFWLAMSSTmyNPIIYCCLNKRFRAGF 282
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
364-637 2.63e-14

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 73.52  E-value: 2.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTG-AGC 442
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGR--------WILGqVLC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISS--YMKVSICLPM 520
Cdd:cd15064  74 DIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTpdSEDPSECLIS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 D-----IDSPLSQLYVMSLLVLNVlafvvicgcYTHIYLTvrnpnitsSSSDTKIAKRMAMLIFTDFLCMAPisFFAIsa 595
Cdd:cd15064 154 QdigytIFSTFGAFYIPLLLMLIL---------YWKIYRA--------AARERKAAKTLGIILGAFIVCWLP--FFLV-- 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   596 SLKVPL---ITVSKS--KILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15064 213 ALIVPLcshCWIPLAlkSFFLWLGY-FNSLINPLIYTFFNKDFRKAF 258
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
367-637 3.52e-14

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 73.00  E-value: 3.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISIlAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYaidWQTG-AGCDAA 445
Cdd:cd15326   6 VLGAFILF-AIVGNILVILSVVCNRHLRIPTNYFIVNLAIADL-----LLSFTVLPFSATLEILGY---WVFGrIFCDIW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKvsiclPMDIDSP 525
Cdd:cd15326  77 AAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAP-----PDDKVCE 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQ--LYVM-SLLVLNVLAFVVICGCYTHIYLTVrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPisFF------AISAS 596
Cdd:cd15326 152 ITEepFYALfSSLGSFYIPLIVILVMYCRVYIVA-----LKFSREKKAAKTLGIVVGMFILCWLP--FFialplgSLFSH 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   597 LKVPLITVsksKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15326 225 LKPPETLF---KIIFWLGY-FNSCLNPIIYPCSSKEFKRAF 261
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
367-637 1.06e-13

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 71.98  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGiyLLLIASVDVHTKTEYHNYAIDWqtgagCDAAG 446
Cdd:cd15051   5 VVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLG--LLVLPFSAIYELRGEWPLGPVF-----CNIYI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPI--------FGISSYMKVSICL 518
Cdd:cd15051  78 SLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhlgwntpdGRVQNGDTPNQCR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 pmdidSPLSQLYVmslLVLNVLAF----VVICGCYTHIYLTVR----------------NPNITSSSSDTKIAKRMAMLI 578
Cdd:cd15051 158 -----FELNPPYV---LLVAIGTFylplLIMCGVYLRIFRIAReqakrinaltpastanSSKSAATAREHKATVTLAAVL 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   579 FTDFLCMAP-ISFFAISASLKVPLITVSKSkILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15051 230 GAFIICWFPyFTYFTYRGLCGDNINETALS-VVLWLGY-ANSALNPILYAFLNRDFRRAF 287
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
364-637 1.12e-13

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 72.42  E-value: 1.12e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIgIYLLLIASVdVHTKTEyhnyaiDWQTG-AGC 442
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLV-IIICLPATL-LVDVTE------TWFFGqVLC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVA--------LFPIFGISSYMKV 514
Cdd:cd15208  74 KIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMipqaivmeCSRVVPLANKTIL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   515 -SICLPMDIDSPLSQLY-VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDT----------------------KI 570
Cdd:cd15208 152 lTVCDERWSDSIYQKVYhICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVqrkwnkprksavaaeekqlrsrRK 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   571 AKRMAMLIFTDF-LCMAPISFFAISASLKVpLITVSKSKILL------VLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15208 232 TAKMLIVVVIMFaICYLPVHLLNILRYVFG-LFTVDRETIYAwflfshWLVY-ANSAINPIIYNFMSGKFREEF 303
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
364-637 1.15e-13

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 72.07  E-value: 1.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITS---QYKLTVPRFLMcNLAFADLcigiyLLLIASVDVHTKTeyhnYAI-DWQTG 439
Cdd:cd15098   2 IVPVVFGLIFCLGVLGNSLVITVLARVkpgKRRSTTNVFIL-NLSIADL-----FFLLFCVPFQATI----YSLpEWVFG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AG-CDAAGFFTVFASELSVYTLTAITLERWHTITHA---MQLECKvqlRHAASIMLVGWIFAFAVAL-----FPIFGISS 510
Cdd:cd15098  72 AFmCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSrtsSSLRTR---RNALLGVLVIWVLSLAMASpvavhQDLVHHWT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   511 YMKVSICLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYT----HIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCM 585
Cdd:cd15098 149 ASNQTFCWENWPEKQQKPVYVVCTFVFGyLLPLLLITFCYAkvlnHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISW 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   586 APISFFAISASL-KVPLitVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15098 229 LPHHIIHLWVEFgDFPL--TQASFVLRITAHCLayaNSCVNPIIYAFLSENFRKAY 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
372-637 1.43e-13

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 71.27  E-value: 1.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIdwqtgagCDAAGFFTVF 451
Cdd:cd15206  10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVM-------CKLIPYFQAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFA-VALFPIFGISSYM--KVSICLPMDIDSPLSQ 528
Cdd:cd15206  83 SVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLiMSPILVFSNLIPMsrPGGHKCREVWPNEIAE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 L--YVMSLLVLNVLAFVVICGCYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPI-------SFFAISASLKV 599
Cdd:cd15206 163 QawYVFLDLMLLVIPGLVMSVAYGLISWTLL-------EAKKRVIRMLFVIVVEFFICWTPLyvintwkAFDPPSAARYV 235
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   600 PLITVSkskILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15206 236 SSTTIS---LIQLLAY-ISSCVNPITYCFMNKRFRQAF 269
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
369-637 1.47e-13

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 71.64  E-value: 1.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   369 IWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTkteyhnyaIDWQTGA-GCDAAGF 447
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEAT--------GEWVAGDvLCRIVKY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQlecKVQLRHAASIM-LVGWIFAFAVALfPIFGISSYMKVSICLPMDIDSPL 526
Cdd:cd14986  79 LQVVGLFASTYILVSMSLDRYQAIVKPMS---SLKPRKRARLMiVVAWVLSFLFSI-PQLVIFVERELGDGVHQCWSSFY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 S----QLYVMSLLVL-NVLAFVVICGCYTHIYLTV------------------RNPNITSSSSDTKIAK------RMAML 577
Cdd:cd14986 155 TpwqrKVYITWLATYvFVIPLIILSYCYGRILRTIwirsrqktdrpiaptamsCRSVSCVSSRVSLISRakiktiKMTLV 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   578 IFTDF-LCMAP---ISFFAISASLKVPLITVSkskILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14986 235 IILAFiLCWTPyfiVQLLDVYAGMQQLENDAY---VVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
371-637 1.84e-13

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 70.81  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliaSVDVHTKTEYHNYaidWQTGAG-CDAAGFFT 449
Cdd:cd15049   9 SLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLV-----SMNLYTVYLVMGY---WPLGPLlCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG---ISSYMKV--SICLPMDIDS 524
Cdd:cd15049  81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGwqyFVGERTVpdGQCYIQFLDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PlsqlYVMslLVLNVLAF----VVICGCYTHIYLTvrnpnitsSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600
Cdd:cd15049 161 P----AIT--FGTAIAAFylpvLVMTILYWRIYRE--------TARERKAARTLSAILLAFIITWTPYNILVLVSTFCAK 226
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 544349   601 LITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15049 227 CIPDTLWSFGYWLCY-INSTINPFCYALCNKTFRKTF 262
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
364-635 2.39e-13

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 70.94  E-value: 2.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLiasvdvhtKTEYHNYAIDWQTGAG-C 442
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVL--------QNLSIYLIPSWPFGEVlC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFPIFGISSYMKVS------- 515
Cdd:cd15012  73 RMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTS-AVYNTPYFVFSQTVEILvtqdgqe 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 --ICLpMDIDSPLSQLYVM-SLLVLNVLAFVVICGCYTHIYLTVrnpnitsSSSDTKIAK----RMAMLIFTDF-LCMAP 587
Cdd:cd15012 152 eeICV-LDREMFNSKLYDTiNFIVWYLIPLLIMTVLYSKISIVL-------WKSSSIEARrkvvRLLVAVVVSFaLCNLP 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   588 ISFFAISASLKVPLITVSKSKILLV----LFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15012 224 YHARKMWQYWSEPYRCDSNWNALLTpltfLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
372-637 2.43e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 71.00  E-value: 2.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTGAG-CDAAGFFTV 450
Cdd:cd15399  10 IILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLV--------YTLLDEWKFGAVlCHLVPYAQA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHamQLECKVQLRHAASIMLVGWIFAFAVAL-------FPIFGISSYMKVSIC---LPM 520
Cdd:cd15399  82 LAVHVSTVTLTVIALDRHRCIVY--HLESKISKKISFLIIGLTWAASALLASplaifreYSVIEISPDFKIQACsekWPN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSD------TKIAKRMAMLIFTDFLCMAPISFFAIS 594
Cdd:cd15399 160 GTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDhyhqrrRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   595 ASLKVPLITVSKSKILLVLFYPINSC---ANPFLYAIFTKNFRRDF 637
Cdd:cd15399 240 SDIDSKVLDLKEYKLIYTIFHVIAMCstfANPLLYGWMNNNYRTAF 285
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
367-637 4.66e-13

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 70.15  E-value: 4.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTG-AGCDAA 445
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDII--------WRITVEWRAGdFACKVI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQ-LECKVQLRHAASimlVGWIFAFAVALfPIFGISSYMKVS-------IC 517
Cdd:cd15197  77 RYLQVVVTYASTYVLVALSIDRYDAICHPMNfSQSGRQARVLIC---VAWILSALFSI-PMLIIFEKTGLSngevqcwIL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDsplSQLYvMSLLVLNVLAF--VVICGCYTHIYLTV---------------RNPNITSSSSDTKIAK------RM 574
Cdd:cd15197 153 WPEPWY---WKVY-MTIVAFLVFFIpaTIISICYIIIVRTIwkkskiqvtinkaglHDGSSRRSSSRGIIPRakiktiKM 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   575 AMLIFTDF-LCMAPISFFAISASLKvpLITVSKSKILLVLFY----PINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15197 229 TFVIVTVFiICWSPYFVFDLLDVFG--LLPRSKTKIAAATFIqslaPLNSAINPLIYCLFSTHLCRPL 294
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
371-637 4.69e-13

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 70.46  E-value: 4.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIgiyLLLIASVDVHTKTEYHNYAIDwqtgagcDAAGFFTV 450
Cdd:cd14979   9 AIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLI---LLVGLPVELYNFWWQYPWAFG-------DGGCKLYY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASEL----SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF--GISSYMKV--------SI 516
Cdd:cd14979  79 FLFEActyaTVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFlmGIQYLNGPlpgpvpdsAV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTV-RNPNITSS----------SSDTKIAKRMAMLI-----FT 580
Cdd:cd14979 159 CTLVVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLrSMRNIKKGtraqgtrnveLSLSQQARRQVVKMlgavvIA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   581 DFLCMAP-----ISFFAISaSLKVPLITVSKSKILL--VLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14979 239 FFVCWLPfhaqrLMFSYAS-KEDTFLFDFYQYLYPIsgILFY-LSSAINPILYNLMSSRFRVAF 300
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
374-637 5.66e-13

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 69.78  E-value: 5.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLiasvdvhtKTEYHNYAIDWQTG-AGCDAAGFFTVFA 452
Cdd:cd15162  12 VVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPF--------KIAYHIHGNNWIFGeALCRLVTVAFYGN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKV-----SIC---LPMDIDS 524
Cdd:cd15162  84 MYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL-PLYLVKQTIFLpaldiTTChdvLPEQLLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSL-LVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFL-CMAPISFFAIsASLKVPLI 602
Cdd:cd15162 163 GDWFYYFLSLaIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFIiCFAPSNLLLL-AHYSLISS 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   603 TVSKS----KILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15162 242 SGTGHlyfaYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
367-637 6.76e-13

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 69.17  E-value: 6.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISIlAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLL-LIASVDVHTKteyhnyaidWQTG-AGCDA 444
Cdd:cd15327   6 FLAIFILM-AIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLpFSATLEVLGF---------WAFGrVFCDI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDS 524
Cdd:cd15327  76 WAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYvmSLLVLNVLAFVVICGCYTHIYLTVrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPIsFFAISASLKVPLITV 604
Cdd:cd15327 156 PGYALF--SSLFSFYLPLMVILVMYFRVYVVA-----LKFSREKKAAKTLAIVVGVFILCWFPF-FFVLPLGSFFPALKP 227
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   605 SKS--KILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15327 228 SEMvfKVIFWLGY-FNSCVNPIIYPCSSKEFKRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
364-637 9.75e-13

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 68.84  E-value: 9.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQyKLTVP-RFLMCNLAFADLCIGIYLLLIASVDVhtkteyhnYAIDWQTGAG- 441
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVK-KLRTPsNYLIVSLAVSDLLVALLVMPLAIIYE--------LSGYWPFGEIl 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVS-ICLPm 520
Cdd:cd15329  73 CDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPgVCQV- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 dIDSPLSQLYvmSLLVLNVLAFVVICGCYTHIYLtvrnpnitSSSSDTKIAKRMA--MLIFTdfLCMAPisFFAISASL- 597
Cdd:cd15329 152 -SQDFGYQIY--ATFGAFYIPLIVMLVLYYKIYR--------AAKSERKAIKTLGiiMGAFT--LCWLP--FFILALLRp 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   598 -----KVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15329 217 flkpiKCSCIPLWLSRLFLWLGY-ANSFLNPIIYAKFNREFRTPF 260
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
371-637 1.19e-12

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 69.10  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIG----IYLLLIASvdvhtkteyHNyaiDWQTGAG-CDAA 445
Cdd:cd16004   9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAafntAFNFVYAS---------HN---DWYFGLEfCRFQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMqlecKVQLRHAASIMLVG--WIFAFAVALFPIF--GISSYMKVSICL--- 518
Cdd:cd16004  77 NFFPITAMFVSIYSMTAIAADRYMAIIHPF----KPRLSAGSTKVVIAgiWLVALALAFPQCFysTVTMDQGRTKCIvaw 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLLVL-NVLAFVVICGCYTHIYLTV----------RNPNITSSSSDTKIAKRMAMLIFTDFLCMAP 587
Cdd:cd16004 153 PGDSGGKHQLTYHLAVIVLiYLLPLAVMFVTYSIIGITLwrsavpghqaHGAYHRQLQAKKKFVKTMVVVVVTFAICWLP 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   588 ISFFAISASLKVPLITVSK-SKILLVLFYPINSCA--NPFLYAIFTKNFRRDF 637
Cdd:cd16004 233 YHLYFILGSFNEDIYCQKYiQQVYLAIFWLAMSSTmyNPIIYCCLNQRFRSGF 285
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
374-637 1.56e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 68.16  E-value: 1.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTGAG-CDAAGFFTVFA 452
Cdd:cd15061  11 IFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGY--------WPLGSHlCDFWISLDVLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMK---VSICLPMD----IDSP 525
Cdd:cd15061  83 CTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRrglGSCYYTYDkgyrIYSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNVLA--FVVIcgcythiyltvrnpnitssSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLIT 603
Cdd:cd15061 163 MGSFFLPLLLMLFVYLriFRVI-------------------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDCQFS 223
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   604 VSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15061 224 EALSTAFTWLGY-FNSVINPFIYAFYNKDFRRAF 256
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
364-637 2.15e-12

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 67.96  E-value: 2.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVlVILITSQYKLTVP-RFLMCNLAFADLCIGIYLLLIASVdvhtKTEYHNyaidWQTGAG- 441
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLV-IISISHFKQLHTPtNLLLLSLAVADFLVGLLVMPFSMI----RSIETC----WYFGDTf 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG---ISSYMKVSICL 518
Cdd:cd15055  73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDnlnQPGLIRYNSCY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 pmdiDSPLSQLYVMSLLVLNVLAFV----VICGCYTHIYLTVR-----------------NPNITSSSSDTKIAKRMAML 577
Cdd:cd15055 153 ----GECVVVVNFIWGVVDLVLTFIlpctVMIVLYMRIFVVARsqarairshtaqvslegSSKKVSKKSERKAAKTLGIV 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   578 IFTDFLCMAPisFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15055 229 VGVFLLCWLP--YYIVSLVDPYISTPSSVFDVLIWLGY-FNSCLNPLIYALFYPWFRKAL 285
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
364-637 2.55e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 68.23  E-value: 2.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILV-LVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkTEYHNYaidWQTGAGC 442
Cdd:cd15057   2 ITGCILYLLVLLTLLGNALViAAVLRFRHLRSKVTNYFIVSLAVSDLLVAILVMPWAAV-----NEVAGY---WPFGSFC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF------GISSYMKVSI 516
Cdd:cd15057  74 DVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQlgwhraDDTSEALALY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLY-VMSLLVLNVLAFVVICGCYTHIYLTVR-----------------NPNITSSSS---DTKIAKRMA 575
Cdd:cd15057 154 ADPCQCDSSLNRTYaISSSLISFYIPVAIMIVTYTRIYRIARrqirriaaleraaqestNPDSSLRSSlrrETKALKTLS 233
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   576 MLIFTDFLCMAPisFFAISASLK-----------VPLITVskskILLVLFYPINSCANPFLYAiFTKNFRRDF 637
Cdd:cd15057 234 IIMGVFVCCWLP--FFILNCVLPfcdlrtaqfpcVPDTTF----IVFVWLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
367-634 3.41e-12

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 67.47  E-value: 3.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVdVHTKteyhnYAIDWQTG-AGCD-- 443
Cdd:cd14999   4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADL---LYLLTIPFY-VSTY-----FLKKWYFGdVGCRll 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 -AAGFFTVFASelsVYTLTAITLERWHTITHAMQLECK-VQLRHAASIMLvgWIFAFAVALfPIF--------GISSYMK 513
Cdd:cd14999  75 fSLDFLTMHAS---IFTLTVMSTERYLAVVKPLDTVKRsKSYRKLLAGVI--WLLSLLLTL-PMAimirlvtvEDKSGGS 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   514 VSICLPMDidSPLS-QLYVMSLLVLNVLA-FVVICGCYTHIYLTVRNPNITSSSSDTK--IAKRMAMLIFTDFL----CM 585
Cdd:cd14999 149 KRICLPTW--SEESyKVYLTLLFSTSIVIpGLVIGYLYIRLARKYWLSQAAASNSSRKrlPKQKVLKMIFTIVLvfwaCF 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   586 APISFFAI----SASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd14999 227 LPFWIWQLlylySPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
372-637 4.20e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 67.28  E-value: 4.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADL---CIGIYLLLIASVDVhtKTEYHnyaidwqtgaGCDAAGFF 448
Cdd:cd14968  10 IAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADIlvgALAIPLAILISLGL--PTNFH----------GCLFMACL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGIssYMKVSICLPMdIDSPLSQ 528
Cdd:cd14968  78 VLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGW--NNGAPLESGC-GEGGIQC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYV----MSLLV-LNVLAFV-----VICGCYTHIYLTVRNP--NITSSSS----------DTKIAKRMAMLIFTDFLCMA 586
Cdd:cd14968 155 LFEevipMDYMVyFNFFACVlvpllIMLVIYLRIFRVIRKQlrQIESLLRsrrsrstlqkEVKAAKSLAIILFLFALCWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   587 P------ISFFAisASLKVPLITVskskILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14968 235 PlhiincITLFC--PECKVPKILT----YIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
369-635 5.21e-12

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 67.10  E-value: 5.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   369 IWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiyLLLIASVDVHTKTEYHNYaiDWQTGAG-CDAAGF 447
Cdd:cd15381   7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAAD------LLLVCCLPFWAINISNGF--NWPFGEFlCKSVNA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSYMK---VSICLpmdID 523
Cdd:cd15381  79 VIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTpMIVFRTVMYFPeynITACV---LD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFV----VICGCYTHIYLTVRN---PNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISAS 596
Cdd:cd15381 156 YPSEGWHVALNILLNVVGFLiplsIITFCSTQIIQVLRNnkmQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDT 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   597 LKVPLITVSK---------SKILLVLFYPiNSCANPFLYAIFTKNFRR 635
Cdd:cd15381 236 LHKLGLISGCrwedildigTQIATFLAYS-NSCLNPLLYVIVGKHFRK 282
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
372-635 9.17e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 65.75  E-value: 9.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkTEYHNYaidWQTGA-GCDAAGFFTV 450
Cdd:cd15210  10 FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAAS-----TFLHQA---WIHGEtLCRVFPLLRY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAmQLECKVQLRHAASIMLVG-WIFAFAVALFPIFGISSYM----KVSICLPMDIDSP 525
Cdd:cd15210  82 GLVAVSLLTLVLITLNRYILIAHP-SLYPRIYTRRGLALMIAGtWIFSFGSFLPLWLGIWGRFgldpKVCSCSILRDKKG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVmsllvLNVLAFVVICGCYTHIYltvrnpnitSSSSDTKIAkRMAMLIFTDFL-CMAPISFFAISASL-KVPLIT 603
Cdd:cd15210 161 RSPKTF-----LFVFGFVLPCLVIIICY---------ARREDRRLT-RMMLVIFLCFLvCYLPITLVNVFDDEvAPPVLH 225
                       250       260       270
                ....*....|....*....|....*....|..
gi 544349   604 VskskILLVLFYpINSCANPFLYAIFTKNFRR 635
Cdd:cd15210 226 I----IAYVLIW-LSSCINPIIYVAMNRQYRQ 252
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
364-637 1.14e-11

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 65.44  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYaidWQTG-AGC 442
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVN-----ELMGY---WYFGsVWC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMdi 522
Cdd:cd15059  74 EIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQ-- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 dSPLSQL--YVMSLLVLNVLA-FVVICGCYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPisFFaISASLKV 599
Cdd:cd15059 152 -CELSDDpgYVLFSSIGSFYIpLLIMIIVYARIYRAAK-------RKERRFTLVLGVVMGAFVLCWLP--FF-FTYPLVV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   600 PLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15059 221 VCKTCGVPELLFKFFFWLgycNSALNPVIYTIFNKDFRRAF 261
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
369-635 1.36e-11

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 65.89  E-value: 1.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   369 IWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiYLLLIASVDVHTKTEYHNyaiDWQTG-AGCDAAGF 447
Cdd:cd15336   7 ILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSD-----FLMSLTQSPIFFVNSLHK---RWIFGeKGCELYAF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID---- 523
Cdd:cd15336  79 CGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDymtf 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLV-LNVLAFVVICGCYTHIYLTVRNPN-----------------ITSSSSDTKIAKRMAMLIFTDFLCM 585
Cdd:cd15336 159 TPSVRAYTMLLFCfVFFIPLGIIIYCYLFIFLAIRSTGrevqklgsqdrkekakqYQRMKNEWKMAKIAFVVILLFVLSW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   586 APISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15336 239 SPYACVALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYRE 288
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
364-637 1.68e-11

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 65.32  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIY---LLLIASvdvhtkteYHNyaiDWQTG- 439
Cdd:cd15401   2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYpypLILLAI--------FHN---GWTLGn 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMKVSICLP 519
Cdd:cd15401  71 IHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTL-AAIVPNFFVGSLQYDPRIYS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIY-LTVRNPNITSSSSDTKIAK---RMAMLIFTDF----LCMAPISF 590
Cdd:cd15401 150 CTFAQTVSSSYTITVVVVHfIVPLSIVTFCYLRIWvLVIQVKHRVRQDSKQKLKAndiRNFLTMFVVFvlfaVCWGPLNF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15401 230 IGLAVAINPLKVAPKIPEWLFVLSYFMayfNSCLNAVIYGVLNQNFRKEY 279
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
371-637 3.05e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 64.18  E-value: 3.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLL--IASvdvhtKTEYHNYAIDwqtgAGCDAAGFF 448
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLpqLIW-----DITYRFYGGD----LLCRLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSI----CLPMDIDS 524
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSI-PQLFIFSYQEVGSgvydCWATFEPP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNItssssdtKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLIT 603
Cdd:cd15196 158 WGLRAYITWFTVAVfVVPLIILAFCYGRICYVVWRAKI-------KTVKLTLVVVACYIVCWTPFFVVQMWAAWDPTAPI 230
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   604 VSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15196 231 EGPAFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
367-637 3.96e-11

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 64.41  E-value: 3.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIwFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIY---LLLIASvdvhtkteYHNyaiDWQTGA-GC 442
Cdd:cd15209   6 VLI-VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYpypLILHAI--------FHN---GWTLGQlHC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFPIFGISSYM---KVSICLP 519
Cdd:cd15209  74 QASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLT-VLAVLPNFFIGSLQydpRIYSCTF 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPlsqLYVMSLLVLNVLAFVVICG-CYTHIY---LTVRNPNITSSSSDTKIAK-RMAMLIFTDFL----CMAPISF 590
Cdd:cd15209 153 AQTVST---VYTITVVVIHFLLPLLIVSfCYLRIWvlvLQVRQRVKPDQRPKLKPADvRNFLTMFVVFVlfavCWAPLNF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15209 230 IGLAVAINPKEMAPKIPEWLFVASYFMayfNSCLNAIIYGLLNQNFRKEY 279
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
372-637 4.04e-11

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 64.42  E-value: 4.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIasvdvhtkTEYHNYAIDWQTGA-GCDAAGFFTV 450
Cdd:cd15205  10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPF--------TLLQNISSNWLGGAfMCKMVPFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISS--------YMKVSICLPMDI 522
Cdd:cd15205  82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGS-PMLFVQQlevkydflYEKRHVCCLERW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQ--LYVMSLLVLNVLAFVVICGCYTHI--YLTVRNPNITSSSSDT-------KIAKR-------MAMLIFTDFLC 584
Cdd:cd15205 161 YSPTQQkiYTTFILVILFLLPLTTMLFLYSRIgyELWIKKRVGDASVLQTihgiemsKISRKkkravkmMVTVVLLFAVC 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   585 MAP-------ISFFAISASLKVPLITVSKSKILLVLFYpiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15205 241 WAPfhvvhmmIEYSNLENKYDGVTIKLIFAIVQLIGFS--NSFNNPIVYAFMNENFKKNF 298
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
367-637 5.63e-11

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 63.78  E-value: 5.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFI----SILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiYLLLIASVDVHTKTEYHNyaidWQTGA-- 440
Cdd:cd15970   1 ILISFIysvvCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD-----ELLMLSVPFLVTSTLLRH----WPFGSll 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 -----GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVS 515
Cdd:cd15970  72 crlvlSVDAINMFT------SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVIL-PIIIFSNTAPNS 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ---ICLPMDIDSPLSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSSDTKIAKR----MAMLIFTDF-L 583
Cdd:cd15970 145 dgsVACNMQMPEPSQRWLAVFVVYTFLMGFllpvIAICLCYILIIVKMRVVALKAGWQQRKRSERkitlMVMMVVTVFvI 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   584 CMAPisFFAIS-ASLKVPLITVSKSKILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15970 225 CWMP--FYVVQlVSVFVGQHDATVSQLSVILGYA-NSCANPILYGFLSDNFKRSF 276
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
371-637 6.50e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 63.81  E-value: 6.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILiTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteYHNYAIDWQTGAGCDAAGFFTV 450
Cdd:cd14978   9 VICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIAD--YSSSFLSYFYAYFLPYIYPLAN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALF--------PIFGISSYMKVSICLPMDI 522
Cdd:cd14978  86 TFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPrffeyevvECENCNNNSYYYVIPTLLR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYV---MSLLVLNVLAFVVICGCYTHIYLTVR----------NPNITSSSSDTKIAKRMAMLI---FTDFLCMA 586
Cdd:cd14978 166 QNETYLLKYyfwLYAIFVVLLPFILLLILNILLIRALRkskkrrrllrRRRRLLSRSQRRERRTTIMLIavvIVFLICNL 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   587 PISFFAISASLKVPLITVSKSKILLVLF---YPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14978 246 PAGILNILEAIFGESFLSPIYQLLGDISnllVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
364-637 7.00e-11

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 63.32  E-value: 7.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFAD--LCIGIYLLLIASVDVHtkteyhnyaidWQTG-A 440
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADelFMLGLPFLAIQVALVH-----------WPFGkA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 GC------DAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIF---GISSY 511
Cdd:cd15971  71 ICrvvmtvDGINQFT------SIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVIL-PIMiyaGVQTK 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   512 MKVSIClPMDIDSPLSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSS-----DTKIAKRMAMLIFTDF 582
Cdd:cd15971 144 HGRSSC-TIIWPGESSAWYTGFIIYTFILGFfvplTIICLCYLFIIIKVKSSGIRVGSSkrkksEKKVTRMVSIVVAVFV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   583 LCMAPISFF-AISASLKVPLITVSKS--KILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15971 223 FCWLPFYIFnVSSVSVSISPTPGLKGmfDFVVVLSYA-NSCANPILYAFLSDNFKKSF 279
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
365-637 7.88e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 63.35  E-value: 7.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIW-FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtkteyhNYAIDWQTGAG-C 442
Cdd:cd15978   2 VRILLYsLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIP--------NLLKDFIFGSAvC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFG-ISSYMKVS----- 515
Cdd:cd15978  74 KTATYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLpYPIYSnLVPFTRINnstgn 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ---ICLPMDIDSplSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNpNITSSSSDTKIAKRMAMLIFTDFLCMAPI---- 588
Cdd:cd15978 154 mcrLLWPNDVTQ--QSWYIFLLLILFLIPGIVMMTAYGLISLELYR-GIKFLMAKKRVIRMLIVIVILFFLCWTPIfsan 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   589 ---SFFAISASLKVPLITVSkskILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15978 231 awrAFDTRSADRLLSGAPIS---FIHLLSY-TSACVNPIIYCFMNKRFRMGF 278
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
365-637 8.02e-11

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 63.03  E-value: 8.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYaidWQTG-AGCD 443
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLAN-----ELMGY---WYFGqVWCN 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIfgISSYMKvsiclPMDID 523
Cdd:cd15323  75 IYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL--ISMYRD-----PEGDV 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQL-----YVMSLLVLNVLAFVVICG-CYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPIsFFAIS--- 594
Cdd:cd15323 148 YPQCKLndetwYILSSCIGSFFAPCLIMIlVYIRIYRVAK-------AREKRFTFVLAVVMGVFVVCWFPF-FFSYSlyg 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   595 ---ASLKVPlitvsksKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15323 220 icrEACEVP-------EPLFKFFFWIgycNSSLNPVIYTIFNQDFRRSF 261
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
365-637 8.77e-11

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 63.38  E-value: 8.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYL--LLIASVdvhtkteYHNyaiDWQTG-AG 441
Cdd:cd15402   3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPypLVLTSI-------FHN---GWNLGyLH 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMKVSICLPMD 521
Cdd:cd15402  73 CQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTV-AAIVPNLFVGSLQYDPRIYSCT 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTV----------RNPNITSSSSDTKIAKRMAMLIFTdfLCMAPISF 590
Cdd:cd15402 152 FAQSVSSAYTIAVVFFHfILPIIIVTFCYLRIWILViqvrrrvkpdNKPKLKPHDFRNFVTMFVVFVLFA--VCWAPLNF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15402 230 IGLAVAVDPETIVPRIPEWLFVASYYMayfNSCLNAIIYGLLNQNFRREY 279
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
372-634 9.04e-11

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 63.22  E-value: 9.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILvLVILITSQYKL-TVPRFLMCNLAFADL--CIGIYLLLIAsvdvhtkteyhnYAID---WQTGAGCDAA 445
Cdd:cd15394  10 VVLVGVVGNYL-LIYVICRTKKMhNVTNFLIGNLAFSDMlmCATCVPLTLA------------YAFEprgWVFGRFMCYF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFF----TVFaseLSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMK-----VSI 516
Cdd:cd15394  77 VFLmqpvTVY---VSVFTLTAIAVDRYYVTVYP--LRRRISRRTCAYIVAAIWLLSCGLAL-PAAAHTYYVEfkgldFSI 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQL-YVMSLLVLN-VLAFVVICGCYTHIYLTVRN----PNITSSSSDTKIAK-----RMAMLIFTDF-LC 584
Cdd:cd15394 151 CEEFWFGQEKQRLaYACSTLLITyVLPLLAISLSYLRISVKLRNrvvpGSMTQSQAEWDRARrrktfRLLVVVVVAFaIC 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   585 MAPISFFAISASLKVPLIT---VSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15394 231 WLPLHIFNVIRDIDIDLIDkqyFNLIQLLCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
364-634 9.30e-11

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 62.77  E-value: 9.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILaitGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaiDWQTGAG-C 442
Cdd:cd15213   5 ILMILMIFVGFL---GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITG--------RWIFGDIfC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTIthaMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVS---ICLP 519
Cdd:cd15213  74 RISAMLYWFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPrapQCVL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLV-LNVLAFVVICGCYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLK 598
Cdd:cd15213 151 GYTESPADRIYVVLLLVaVFFIPFLIMLYSYFCILNTVR-------SFKTRAFTTILILFIGFSVCWLPYTVYSLLSVFS 223
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 544349   599 VPL-ITVSKSKILLVLFYpINSCANPFLYAIFTKNFR 634
Cdd:cd15213 224 RYSsSFYVISTCLLWLSY-LKSAFNPVIYCWRIKKFR 259
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
367-637 1.05e-10

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.95  E-value: 1.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIwFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIY---LLLIASvdvhtkteYHNyaiDWQTG-AGC 442
Cdd:cd15400   6 VLI-FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYpypLVLVAI--------FHN---GWALGeMHC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHaaSIMLVGWIFAFAV-ALFPIFGISSYMKVSICLPMD 521
Cdd:cd15400  74 KVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWN--TLLYVCLIWALTVvAIVPNFFVGSLEYDPRIYSCT 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIY---LTVRNPNITSSSSDTKIAK-RMAMLIFTDF----LCMAPISFFA 592
Cdd:cd15400 152 FVQTASSSYTIAVVVIHfIVPITVVSFCYLRIWvlvIQVRRKVKSESKPRLKPSDfRNFLTMFVVFvifaICWAPLNLIG 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   593 ISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15400 232 LAVAINPQEMAPKVPEWLFVVSYFMayfNSCLNAIIYGLLNQNFRKEY 279
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
364-635 1.19e-10

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 62.99  E-value: 1.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQ-YKLTVPRFLMCNLAFADLCIGIYLLLIAsvdVHTKTEYhnyaiDWQTG-AG 441
Cdd:cd15926   2 IISIVYSVVCALGLVGNLLVLYLMKSKQgWKKSSINLFVTSLAVTDFQFVLTLPFWA---VENALDF-----TWLFGkAM 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLEcKVQLRHAASIMLVgWIFAFAV-ALFPIFGISSYMKVS---IC 517
Cdd:cd15926  74 CKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSK-RRRGCCSAKWLCV-LIWVLAIlASLPNAIFSTTATVSneeLC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSP------LSQLYVMSLLVLNVLAFVVICGCYTHI--YLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAP-I 588
Cdd:cd15926 152 LVKFPDNRgnaqfwLGLYHAQKVLLGFLIPLGIISLCYLLLvrFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPnQ 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   589 SFFAISASLKVPLITVSKSKILL-VLFYPI-------NSCANPFLYAIFTKNFRR 635
Cdd:cd15926 232 ALTTWGILIKLNVVHFSYEYFTTqVYIFPItvclahsNSCLNPILYCLMRREFRK 286
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
367-637 1.20e-10

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 63.03  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIA-SVDVHTKTEYHnyaidwqtgaGCDAA 445
Cdd:cd15069   5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAiTISLGFCTDFH----------SCLFL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDS- 524
Cdd:cd15069  75 ACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTNPADHg 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 ----------------PLSQLYVMSLLVLNVLAFVVICGCYTHIYLT---------VRNPNITSSSSDTKIAKRMAMLIF 579
Cdd:cd15069 155 tnhscclisclfenvvPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVacrqlqrteLMDHSRTTLQREIHAAKSLAIIVG 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   580 TDFLCMAPISFFAiSASLKVPLITVSKSKILL---VLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15069 235 IFALCWLPVHILN-CITLFQPEFSKSKPKWAMnvaILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
372-637 1.55e-10

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 62.68  E-value: 1.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVlvILITSQYK--LTVPRFLMCNLAFADLcigIYLLLIASVdvhTKTEYHNYaiDWQTGAG-CDAAGFF 448
Cdd:cd15095  10 IFLVGLAGNSLV--IYVVSRHRemRTVTNYYIVNLAVTDL---AFLVCCVPF---TAALYATP--SWVFGDFmCKFVNYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 ---TVFASELsvyTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-----FPIFGISSYMKVSICLPM 520
Cdd:cd15095  80 mqvTVQATCL---TLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIpvaiyYRLEEGYWYGPQTYCREV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLY-VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMA-------------MLIFTdfLCMA 586
Cdd:cd15095 157 WPSKAFQKAYmIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALrqkrkvtrmvivvVVLFA--ICWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   587 PIS----FFAISASLKVPlITVSKSKIL-LVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15095 235 PNHvlnlWQRFDPNFPET-YATYALKIAaLCLSYA-NSAVNPFVYAFMGENFRKYF 288
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
372-637 2.09e-10

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 61.74  E-value: 2.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkTEYHNYaidWQTG-AGCDAAGFFTV 450
Cdd:cd15062  10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSAT-----LEVLGY---WAFGrIFCDVWAAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSymkvsiclPMDIDSPLSQL- 529
Cdd:cd15062  82 LCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKE--------PAPADEQACGVn 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   530 ----YVM-SLLVLNVLAFVVICGCYTHIYLTVrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPIsFFAISASLKVPLITV 604
Cdd:cd15062 154 eepgYVLfSSLGSFYLPLAIILVMYCRVYVVA-----FKFSREKKAAKTLGIVVGAFVLCWFPF-FVVLPLGSLFSTLKP 227
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   605 SKS--KILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15062 228 PEPvfKVVFWLGY-FNSCLNPIIYPCSSREFKRAF 261
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
367-637 2.61e-10

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 61.90  E-value: 2.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVhTKTEYHNYaiDWQTGA-GCDAA 445
Cdd:cd15927   5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDL-----LLLLTCVPF-TSTIYTLD--SWPFGEfLCKLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRH----AASIMLVGWIFAFAVALFP---IFGISSYMKVSICL 518
Cdd:cd15927  77 EFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRtlvtAASIWIVSILLAIPEAIFShvvTFTLTDNQTIQICY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDidSPLSQLY--VMSL---LVLNVLAFVVICGCYT----HIYLTVRNPNITSSSSDT-------KIAKRMAMLIFTDF 582
Cdd:cd15927 157 PYP--QELGPNYpkIMVLlrfLVYYLIPLLIIGVFYVlmarHLIRSTRNIGSGQNQAAQrqiearkKVAKTVLAFVVLFA 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   583 LCMAPIS------FFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15927 235 VCWLPRHvfmlwfHFAPNGLVDYNAFWHVLKIVGFCLSF-INSCVNPVALYLLSGSFRRHF 294
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
367-637 2.65e-10

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 61.74  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhTKTEYHNYAIDWqtgagCDAAG 446
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVN--EVLDVWIFGHTW-----CQIWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDSPL 526
Cdd:cd15063  78 AVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPC 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 ------SQLYVM-SLLVLNVLAFVVICGCYTHIYLTVRnpnitsssSDTKIAKRMAMLIFTDFLCMAPisFFAISasLKV 599
Cdd:cd15063 158 tceltnGRGYVIySALGSFYIPMLVMLFFYFRIYRAAR--------METKAAKTVAIIVGCFIFCWLP--FFTVY--LVR 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   600 PLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15063 226 AFCEDCIPPLLFSVFFWLgycNSALNPCIYALFSRDFRFAF 266
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
364-637 3.01e-10

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 61.89  E-value: 3.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISIlAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNyaiDWQTG-AGC 442
Cdd:cd15125   3 IPSLYLLIITV-GLLGNITLVKIFITNSAMRSVPNIFISSLAAGDL-----LLLVTCVPVDASRYFYE---EWMFGtVGC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQL----RHAASIMLVGWIFAFAVALFP-IFGISSYMKVSI- 516
Cdd:cd15125  74 KLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVlrtcLKAIAIWVVSVLLAVPEAVFSeVAHIMPDDNTTFt 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 -CLPMDI-DSPLSQLY-VMSLLVLNVLAFVVICGCYTHIYLT-------VRNPNITSSSSDTKIAKRMA--MLIFTDF-- 582
Cdd:cd15125 154 aCIPYPQtDEMHPKIHsVLIFLVYFLIPLAIISIYYYHIAKTliksahnIPGEYSEHSKRQMETRKRLAkiVLVFVGLfa 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   583 LCMAPISFFAISASLKVPLITVSKSKILLVLFYPI----NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15125 234 FCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLVARVlsfcNSCVNPFALYLLSESFRRHF 292
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
368-637 4.22e-10

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 61.09  E-value: 4.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILAITGNILVLVILITSQyKLTVPRFL-MCNLAFADLCIGIYLLLIASVDvhtktEYHNYAIDWQTGagCDAAG 446
Cdd:cd15321  12 AITFLILFTIFGNVLVIIAVLTSR-SLRAPQNLfLVSLAAADILVATLIIPFSLAN-----ELMGYWYFRKTW--CEIYL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPmdiDSPL 526
Cdd:cd15321  84 ALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLP---QCKL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQ--LYVMSLLVLNVLA-FVVICGCYTHIYLTVRNpnitsssSDTKIAKRMAMLIFTDFLCMAPIsFFAISASLKVPLIT 603
Cdd:cd15321 161 NEeaWYILSSSIGSFFApCLIMILVYLRIYLIAKN-------REKRFTFVLAVVIGVFVLCWFPF-FFSYSLGAICPELC 232
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 544349   604 VSKSKILLVLFYP--INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15321 233 KVPHSLFQFFFWIgyCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
372-637 5.29e-10

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 61.11  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLliasvdvhtkteyhNYAIDWQTG--AGCDAAGFFT 449
Cdd:cd15068  10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI--------------PFAITISTGfcAACHGCLFIA 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFA---SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG-------ISSYMKVSICLP 519
Cdd:cd15068  76 CFVlvlTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGwnncgqpKEGKNHSQGCGE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLV-LNVLAFVVI-----CGCYTHIYLTVRN----------PNITSSSS---DTKIAKRMAMLIFT 580
Cdd:cd15068 156 GQVACLFEDVVPMNYMVyFNFFACVLVplllmLGVYLRIFLAARRqlkqmesqplPGERARSTlqkEVHAAKSLAIIVGL 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   581 DFLCMAPI------SFFAISASlKVPLITVskskILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15068 236 FALCWLPLhiincfTFFCPDCS-HAPLWLM----YLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
372-637 7.63e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 59.98  E-value: 7.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliaSVDVHTkteyhNYAI--DWQTG-AGCDAAGFF 448
Cdd:cd17790  10 LSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAF-----SMNLYT-----TYILmgHWALGtVACDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAF-----AVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd17790  80 DYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFvlwapAILFWQYLVGERTVLAGQCYIQFLS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLsqLYVMSLLVLNVLAFVVICGCYTHIYltvrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLIT 603
Cdd:cd17790 160 QPI--ITFGTAIAAFYLPVTIMIILYWRIY--------RETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVP 229
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   604 VSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd17790 230 KTLWELGYWLCY-VNSTVNPMCYALCNKSFRDTF 262
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
372-637 7.65e-10

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 60.50  E-value: 7.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQY--KLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYaidWQTG-AGCDAAGFF 448
Cdd:cd15002   9 ICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADL-----LLLLFSVPFRAAAYSKGS---WPLGwFVCKTADWF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALfPIF---GISSYMKVSICLpMDIDSP 525
Cdd:cd15002  81 GHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPL-PQWlfrTVKQSEGVYLCI-LCIPPL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSSDTKIAKR-----MAMLIFTDFLCMAP--ISFFAI- 593
Cdd:cd15002 158 AHEFMSAFVKLYPLFVFclplTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRklthmLLSVVLAFTILWLPewVAWLWLi 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   594 ----SASLKVPLITVSkSKILLVlfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15002 238 hiksSGSSPPQLFNVL-AQLLAF----SISSVNPIIFLLMSEEFREGF 280
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
371-637 8.39e-10

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 60.17  E-value: 8.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVL-VILITSQYKlTVPRFLMCNLAFAD--LCIGIYLLLIASVDVHtkteyhnyaidWQTGA------- 440
Cdd:cd15093   9 VVCLVGLCGNSLVIyVVLRYAKMK-TVTNIYILNLAIADelFMLGLPFLAASNALRH-----------WPFGSvlcrlvl 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIF---GISSYMKVSIC 517
Cdd:cd15093  77 SVDGINMFT------SIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVIL-PVVvfaGTRENQDGSSA 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLSQLYVMSLLVLNVLAFV----VICGCYTHIYLTVRNPNITSSS-----SDTKIAKRMAMLIFTDFLCMAPI 588
Cdd:cd15093 150 CNMQWPEPAAAWSAGFIIYTFVLGFLlpllIICLCYLLIVIKVKSAGLRAGWqqrkrSERKVTRMVVMVVVVFVICWLPF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   589 SFFAI---SASLKVPLITVSKSKILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15093 230 YVLQLvnvFVQLPETPALVGVYHFVVILSYA-NSCANPILYGFLSDNFKKSF 280
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
372-637 9.65e-10

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 60.04  E-value: 9.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVIL-ITSQYKlTVPRFLMCNLAFADLCIGIYllliaSVDVHTKTEYHNYaidWQTGA-GCDAAGFFT 449
Cdd:cd15300  10 VSLITIVGNVLVMISFkVNSQLK-TVNNYYLLSLACADLIIGIF-----SMNLYTSYILMGY---WALGSlACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMKVSICLPMDidspLSQL 529
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISF-ILWAPPILCWQYFVGKRTVPER----ECQI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   530 YVMSLLVLN----VLAFVVICGCYTHIYLTVRNPNItsssSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVS 605
Cdd:cd15300 156 QFLSEPTITfgtaIAAFYIPVSVMTILYCRIYKETI----KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLT 231
                       250       260       270
                ....*....|....*....|....*....|..
gi 544349   606 KSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15300 232 LWHLGYWLCY-VNSTVNPMCYALCNKTFRKTF 262
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
363-637 1.03e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 60.15  E-value: 1.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhtkteYHNYAIDWQTGA-G 441
Cdd:cd15191   1 TAIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWAT--------YYSYGYNWLFGSvM 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKvQLRHAASIMLVGWIFAFAVAL--------FPIfgisSYMK 513
Cdd:cd15191  73 CKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQRR-RSWQARLVCLLVWVLACLSSLptfyfrdtYYI----EELG 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   514 VSICLPMDIDSPLSQLYVMSLLVLNVLAF----VVICGCYTHI---YLTVRNPNITSSSSDtKIAKRMAMLIFTDFLCMA 586
Cdd:cd15191 148 VNACIMAFPNEKYAQWSAGLALMKNTLGFliplIVIATCYFGIgrhLLKTKGFGKNKQRRD-KVLKMVAAVVLAFLICWF 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   587 P---ISFFAISASLKVPLITVSKSKILLVLFYPI-----NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15191 227 PfhvLTFLDALARMGVINNCWVITVIDKALPFAIclgfsNSCINPFLYCFVGNHFREKL 285
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
372-637 1.18e-09

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 59.88  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiyllliASVDVHTKTEYHNYAI--DWQTG-AGCDAAGFF 448
Cdd:cd16002  10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAE----------ASMSAFNTVINFTYAIhnEWYYGlEYCKFHNFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAlFPIFGISSYMKVS---ICL---PMDI 522
Cdd:cd16002  80 PIAAVFASIYSMTAIALDRYMAIIHPLQP--RLSATATKVVICVIWVLAFLLA-FPQGYYSDTEEMPgrvVCYvewPEHE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGC-YTHIYLTVRNPNITSSSSDT---------KIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd16002 157 ERKYETVYHVCVTVLIYFLPLLVIGCaYTVVGITLWASEIPGDSSDRyheqvsakrKVVKMMIVVVCTFAICWLPYHIYF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   593 ISASLKVPLITVS--KSKILLVLFYPINSCA-NPFLYAIFTKNFRRDF 637
Cdd:cd16002 237 LLQYFHPELYEQKfiQQVYLAIMWLAMSSTMyNPIIYCCLNDRFRVGF 284
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
365-637 1.51e-09

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 59.32  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVdVHtkteYHNYAIDWQTGA-GCD 443
Cdd:cd15375   3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDL---LYVTSLPFL-IY----YYINGESWIFGEfMCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFPIFGISSYMKV---SICLPM 520
Cdd:cd15375  75 FIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVIS-LAEVSPMTFLITTKEKnnrTICLDF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLYVMSLLvLNVLAF----VVICGCYTHIYLTVRNPNITSSSSDTKiAKRMAMLIFTDF-LCMAPISFF-AIS 594
Cdd:cd15375 154 TSSDNLNTIWWYNWI-LTVLGFllplVIVTLCYTRIIYTLAKGPHTGSASKQK-ARRLIILILLVFyVCFLPFHILrVVR 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   595 ASLKVPLITVSKSKILLVLFY---PI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15375 232 IETRLPPVSCCLKHQVHAIYIitrPLaalNTFGNLLLYVVSGDNFQQAF 280
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
371-637 1.54e-09

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 59.31  E-value: 1.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLI-ASVDVHTKteyhnyaidWQTG-AGCDAAGFF 448
Cdd:cd15066   8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFnASVEITGR---------WMFGyFMCDVWNSL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFgiSSYMKVSICLPMDIDSPLSQ 528
Cdd:cd15066  79 DVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIF--LGWYTTEEHLQYRKTHPDQC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMS---LLVLNVLAF----VVICGCYTHIYLTVRNPNitssssdtKIAKRMAMLIFTDFLCMAPISFFAISASL---- 597
Cdd:cd15066 157 EFVVNkiyALISSSVSFwipcIVMIFTYYRIYLEAKREH--------KAAKTLGIIMGAFILCWLPFFLWYVTTTLcgda 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 544349   598 -KVPLITVSkskillVLFYP--INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15066 229 cPYPPILVS------ILFWIgyFNSTLNPLIYAYFNRDFREAF 265
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
364-634 1.54e-09

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 59.78  E-value: 1.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVL-VILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIAsvdVHTKTEYHnyaidWQTG-AG 441
Cdd:cd15190  12 LIPVIYMLVFVLGLSGNGLVLwTVFRSKRKRRRSADTFIANLALADLTFVVTLPLWA---VYTALGYH-----WPFGsFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQlecKVQLRHAASIML---VGWIFAFAVALFPIF-----GISSYMK 513
Cdd:cd15190  84 CKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLA---SAKLRSRTSGIValgVIWLLAALLALPALIlrttsDLEGTNK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   514 VsICLpMDIDSPLSQ---------LYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRM----AMLIFT 580
Cdd:cd15190 161 V-ICD-MDYSGVVSNesewawiagLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLlkiiITLVVT 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   581 DFLCMAPISFF-AISASLKVPLITVSKS-KILLVLFYP-------INSCANPFLYAIFTKNFR 634
Cdd:cd15190 239 FALCWLPFHLVkTLYALMYLGILPFSCGfDLFLMNAHPyatclayVNSCLNPFLYAFFDPRFR 301
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
367-637 1.58e-09

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 59.44  E-value: 1.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVP--RFLMCNLAFADLCIGIYLLLIAsvdVHTKTEYHnyaidWQTG-AGCD 443
Cdd:cd14976   5 VVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTDLIFVLTLPFWA---VEYALDFV-----WPFGtAMCK 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSY--MKVSICLpM 520
Cdd:cd14976  77 VVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIpEAIFSTDTWssVNHTLCL-L 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLYVMSLLVLN-----VLAFV----VICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFF 591
Cdd:cd14976 156 RFPKNSSVTRWYNWLGMYqlqkvVLGFFlplgIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQAL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   592 AI-SASLKVPLITVSKSKILL-VLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd14976 236 SLwSALIKFDDVPFSDAFFAFqTYAFPVaiclahsNSCLNPVLYCLVRREFRDAL 290
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
364-637 1.65e-09

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 58.98  E-value: 1.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyhnYAI--DWQTGAG 441
Cdd:cd15060   2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVA----------YFLlgKWLFGIH 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 -CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGIS----SYMKVSI 516
Cdd:cd15060  72 lCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNdwpeNFTETTP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMD-----IDSPLSQLYVmSLLVLNVLafvvicgcYTHIYLtvrnpnitSSSSDTKIAKRMAMLIFTDFLCMAPisFF 591
Cdd:cd15060 152 CTLTEekgyvIYSSSGSFFI-PLLIMTIV--------YVKIFI--------ATSKERRAARTLGIIMGVFVVCWLP--FF 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   592 AISASLkvPLITVSKSKILLVLFYP----INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15060 213 LMYVIL--PFCETCSPSAKVVNFITwlgyVNSALNPVIYTIFNLDFRRAF 260
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
367-637 1.79e-09

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 59.15  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILItsQYKLT---VPRFLMcNLAFADLCIGIYLLLIAsvdvhtkteyHNYAIDWQTGAG-C 442
Cdd:cd14984   5 VLYSLVFLLGLVGNSLVLLVLL--YYRKLrsmTDVYLL-NLALADLLFVLTLPFWA----------VYAADGWVFGSFlC 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAA-GFFTV-FASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFG-ISSYMKVSICL 518
Cdd:cd14984  72 KLVsALYTInFYS--GILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLpEFIFSqVSEENGSSICS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLLVLNVLAFV----VICGCYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAIS 594
Cdd:cd14984 150 YDYPEDTATTWKTLLRLLQNILGFLlpllVMLFCYSRIIRTLLR---ARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   595 ASLKVPLITVSKSKILLVLFYPI---------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd14984 227 DTLQLLGIISRSCELSKSLDYALqvteslafsHCCLNPVLYAFVGVKFRKYL 278
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
371-641 1.81e-09

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 59.19  E-value: 1.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGiylllIASVDVHTKTEYHNYaidWQTGA-GCDAAGFFT 449
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIG-----VISMNLFTTYIIMNR---WALGNlACDLWLSID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMKVSICLPMdiDSPLSQL 529
Cdd:cd15299  84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISF-VLWAPAILFWQYFVGKRTVPP--DECFIQF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   530 YVMSLLVLN--VLAFVVICGCYTHIYLTVRNPNItsssSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKS 607
Cdd:cd15299 161 LSEPIITFGtaIAAFYLPVTIMTILYWRIYKETI----KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYW 236
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   608 KILLVLFYpINSCANPFLYAIFTKNFRRDFFILL 641
Cdd:cd15299 237 NLGYWLCY-INSTVNPVCYALCNKTFRTTFKMLL 269
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
368-637 2.23e-09

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 58.83  E-value: 2.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILAIT-GNILVLVILITSQYKLTVPRFLMCNLAFADLCIG-------IYLLLIASVDVHTKTeyhnyaidwqtg 439
Cdd:cd15310   5 LSYCALILAIVfGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVAtlvmpwvVYLEVTGGVWNFSRI------------ 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 aGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKV---QLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSI 516
Cdd:cd15310  73 -CCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTgqsSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 ClpmDIDSPLSQLYvmSLLVLNVLAFVVICGCYTHIYLTVrnpnitssSSDTKIAKRMAMLIFTDFLCMAPisFFAISA- 595
Cdd:cd15310 152 C---SISNPDFVIY--SSVVSFYLPFGVTLLVYVRIYVVL--------LREKKATQMLAIVLGAFIVCWLP--FFLTHIl 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   596 -----SLKVPLITVSKSKILLVlfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15310 217 nthcqACHVPPELYSATTWLGY----VNSALNPVIYTTFNIEFRRAF 259
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
364-637 2.35e-09

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 59.01  E-value: 2.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFIS-ILAITGNILVLVIlITSQYKLTVPRFLMCNLAFADLCIGIYLLLiaSVdVHTKTEYHnyaidWQTG-AG 441
Cdd:cd15116   1 ILSMVIYSVVfVLGVLGNGLVIFI-TGFKMKKTVNTVWFLNLAVADFLFTFFLPF--SI-AYTAMDFH-----WPFGrFM 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVA----LFPIFGISSYMKVSIC 517
Cdd:cd15116  72 CKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSspsfIFRDTAPSQNNNKIIC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 -----LPMDIDSP-LSQLYVMSLLVLNV--------LAFVVICGCYTHIYLTVRNPNITSSSSDTKIakrMAMLIFTDFL 583
Cdd:cd15116 152 fnnfsLSGDNSSPeVNQLRNMRHQVMTItrfllgflIPFTIIICCYAAIVLKLKRNRLAKSSKPFKI---IAAVIVTFFL 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   584 CMAP------ISFFAISASLKVPLITVSKSKILLVlfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15116 229 CWAPyhilnlLEMEATRSPASVFKIGLPITSSLAF----INSCLNPILYVFMGQDFKKFK 284
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
364-637 2.45e-09

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 59.03  E-value: 2.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVL-VILITSQYKlTVPRFLMCNLAFADLC--IGIYLLLIASVDVHtkteyhnyaidWQTGA 440
Cdd:cd15094   2 ISAVLYGLICIVGLVGNGLVIyVVLRYAKMK-TVTNLYILNLAVADECflIGLPFLIVTMILKY-----------WPFGA 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 G-CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSI--- 516
Cdd:cd15094  70 AmCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVML-PIILYASTVPDSGrys 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNVLAFVVICGC----YTHIYLTVRNPNITSSSSDTKIAKR----MAMLIFTDF-LCMAP 587
Cdd:cd15094 149 CTIVWPDSSAVNGQKAFTLYTFLLGFAIPLLLisvfYTLVILRLRTVGPKNKSKEKRRSHRkvtrLVLTVISVYiICWLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   588 ISFFAISASLKVPLITVSKSKILLVLFYPI----NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15094 229 YWAFQVHLIFLPPGTDMPKWEILMFLLLTVlsyaNSMVNPLLYAFLSENFRKSF 282
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
372-637 2.48e-09

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 58.66  E-value: 2.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGI-YLLLIasvdvhtkteyhnyaidWQTGAGCDAAGFFTV 450
Cdd:cd15342  10 VSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVaYLFLM-----------------FHTGPWTAKLSLYQW 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASE--------LSVYTLTAITLERWHTItHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMdi 522
Cdd:cd15342  73 FLRQglldtsltASVANLLAIAVERHQTI-FTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLKRCSTM-- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 dSPL-SQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSS---SSDTK-------IAKRMAMLIFTDFLCMAPISFF 591
Cdd:cd15342 150 -APLySRSYLVFWALSNLLTFLIMVAVYTRIFIYVRRKSQRMSehhSSHPRyretvlgLMKTVVIILGAFVVCWTPGQVV 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   592 AISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15342 229 LLLDGLGCESCNVLAYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
374-634 2.95e-09

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 58.55  E-value: 2.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLM-CNLAFADLCIGIYLLLIASvdvhtkteYHNYAIDWQTG-AGCDAAGFftVF 451
Cdd:cd15376  12 LVAVLGNGLALWLFVTRERRPWHTGVVFsFNLAVSDLLYALSLPLLAA--------YYYPPKNWRFGeAACKLERF--LF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASEL--SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKV----SICLPMDIDSP 525
Cdd:cd15376  82 TCNLygSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSA-PVLSFSHLEVErhnkTECLGTAVDSR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNV---LAFVVICGCYTHIYLTV-RNPNITssssdTKIAKRMAMLI----------FTDFLCMAPISFF 591
Cdd:cd15376 161 LPTYLPYSLFLAVVgcgLPFLLTLASYLAIVWAVlRSPGIT-----TLEKRKVAALVavvvalyavsFVPYHILRNLNLY 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   592 AISASLKV-----PLITVSKSKILLvlfyPINSCANPFLYAIFTKNFR 634
Cdd:cd15376 236 RRLQWLKAaaslrIYFAYQVTKGLV----TLNMCIHPLLYMAVADSIR 279
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
372-628 3.46e-09

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 58.63  E-value: 3.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaiDWQTG-AGCDAAGFFTV 450
Cdd:cd15212  10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRP-------GWLFGdRLCLANGFFNA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHamQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISS----YMKVSICLPMDI---- 522
Cdd:cd15212  83 CFGIVSTLTMTLISFDRYYAIVR--QPQGKIGRRRALQLLAAAWLTALGFSL-PWYLLASapeyYEKLGFYHCLYVlhsg 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVL-NVLAFVVICGCYTHIYLTVRN------PNITSSS-----SDTKIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd15212 160 PSRLGAAYSSVLIVLcYLLPFALMCFCHYNICKTVRLsesrvrPVTTYAHllrfySEMRTATTVLIMIVFIICCWGPYCL 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPiNSCANPFLYAI 628
Cdd:cd15212 240 LGLVAAAGGYQFPPLMDTVAIWMAWA-NGAINPLIYAI 276
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
374-636 3.93e-09

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 58.29  E-value: 3.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNiLVLVILITSQYKL-TVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTG-AGCDAAGFFTVF 451
Cdd:cd15395  12 ILGVSGN-LALIIIILKQKEMhNVTNILIVNLSFSDLLMTIMCLPFTFV--------YTLMDHWVFGeAMCKLNSMVQCI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAL-FPIFGI-------------SSYMKVSIC 517
Cdd:cd15395  83 SITVSIFSLVLIAIERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVLTSLpFLIFQVltdepfknvnvslDAYKGKYVC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDIDSPLSQLYVMSLLVLNV---LAFVVIcgCYTHIYLTVRNPN--------ITSSSSDTKIAKRMAMLIFTDF-LCM 585
Cdd:cd15395 161 LDQFPSDTIRLSYTTCLLVLQYfgpLCFIFI--CYLKIYIRLKRRNnmmdkmrdNKYRSSETKRINIMLISIVVAFaVCW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   586 APISFFAISASLKVPLITVSKSKILLVLFY---PINSCANPFLYAIFTKNFRRD 636
Cdd:cd15395 239 LPLNIFNAVFDWNHEAIATCNHNLLFLICHltaMISTCVNPIFYGFLNKNFQRD 292
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
364-635 4.21e-09

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 58.25  E-value: 4.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVDVHTKTEYhnyaiDWQTGAG-C 442
Cdd:cd15189   2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL---VFVSGLPFWAMNILNQF-----NWPFGELlC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAV----ALFPIFGISSYMKVSICL 518
Cdd:cd15189  74 RVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLsiptFLLRKIKAIPDLNITACV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 pmdIDSPLSQLYVMSLLVLNVLAFV----VICGCYTHIYLTVRNPNITSSSSDTKIAKRMAM---LIFTDFLCMAPISFF 591
Cdd:cd15189 154 ---LLYPHEAWHFAHIVLLNIVGFLlpllVITFCNYNILQALRTREESTRCEDRNDSKATALvlaVTLLFLVCWGPYHFF 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   592 AISASLKVPLITVSK--------SKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15189 231 TFLDFLFDVGVLDECfwehfidiGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
364-634 4.33e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 57.94  E-value: 4.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYAidWQTGAGCD 443
Cdd:cd15085   2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDL-----MMALCGTTIVTVTNYEGYF--YLGDAFCI 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----MKVSICLP 519
Cdd:cd15085  75 FQGFAVNYFGIVSLWSLTLLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYgpegVQTSCSIG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMS-LLVLNVLAFVVICGCYTHIYLTVRNPNIT-------SSSSDTKIAKRMAMLIFTDFL-CMAPISF 590
Cdd:cd15085 154 WEERSWSNYSYLILyFLMCFVIPVAIIGFSYGNVLRSLHKLNKKieqqggkNCPEEEERAVIMVLAMVIAFLiCWLPYTV 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15085 234 FALIVVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
372-637 4.82e-09

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 57.94  E-value: 4.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlciGIYLLLIASVDVHTKTEYHNY-AIDWQTGAGCDAAGFFTv 450
Cdd:cd15973  10 VCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD---ELFMLSVPFLAASAALQHWPFgSAMCRTVLSVDGINMFT- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 faselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSYMK--VSICLPMDIDSPLS 527
Cdd:cd15973  86 -----SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISpIIIFADTATRKgqAVACNLIWPHPAWS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   528 QLYVMSLLVLNVLAFVV-ICGCYTHIYLTVRNPNITSS-----SSDTKIAkRMAMLIFTDF-LCMAPisFFAIS-ASLKV 599
Cdd:cd15973 161 AAFVIYTFLLGFLLPVLaIGLCYILIIGKMRAVALKAGwqqrrKSEKKIT-RMVLMVVTVFvICWMP--FYVVQlLNLFL 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   600 PLITVSKSKILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15973 238 PRLDATVNHASLILSYA-NSCANPILYGFLSDNFRRSF 274
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
374-634 5.69e-09

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 57.88  E-value: 5.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIgiylLLIASVDVHTKTEYHnyaiDWQTG-AGCDAAGFFTVFA 452
Cdd:cd15928  12 LVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI----FLVLPLDLYRLWRYR----PWRFGdLLCRLMYFFSETC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAF--AVALFPIFGISSYMKVSI-----CLPMDIDSP 525
Cdd:cd15928  84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIvsAGPALVLVGVEHIQGQQTprgfeCTVVNVSSG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LsqLYVMsLLVLNVLAFVVICgCYTHIY-LTVRNPNITSSSSDTKIAKR-----------MAMLIFTDFLCMAP------ 587
Cdd:cd15928 164 L--LSVM-LWVSTSFFFVPMV-CLSLLYgLIGRALWDRRQRSRTAGASRrdnnhrqtvrmLAVIVLAFVLCWLPfhvgrv 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   588 ISFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFR 634
Cdd:cd15928 240 IFNHSRASTKHLHYVSQYFNLVSFVLFY-LSAAINPILYNLMSKRYR 285
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
365-634 6.51e-09

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 57.53  E-value: 6.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQyKLTVP-RFLMCNLAFADLCigiylLLIASVDVHTKTEYHNYAIDWQTGagCD 443
Cdd:cd15080   3 LAAYMFLLILLGFPINFLTLYVTVQHK-KLRTPlNYILLNLAVADLF-----MVFGGFTTTMYTSMHGYFVFGPTG--CN 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDID 523
Cdd:cd15080  75 LEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGID 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 ------SPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDT-----KIAKRMAMLIFTDFL-CMAPISF 590
Cdd:cd15080 154 yytlkpEVNNESFVIYMFVVHfTIPLIVIFFCYGRLVCTVKEAAAQQQESATtqkaeKEVTRMVIIMVIAFLiCWVPYAS 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   591 FAI-----SASLKVPLITVSKSkillvLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15080 234 VAFyifthQGSDFGPIFMTIPA-----FFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
367-637 6.59e-09

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 57.38  E-value: 6.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYK-LTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIdwqtgagCDAA 445
Cdd:cd15104   4 VILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVL-------CLLR 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIfGISSYMKVSICLPMDIDSP 525
Cdd:cd15104  77 MCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPL-ISPQFQQTSYKGKCSFFAA 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNVL-AFVVICGCYTHIYLTVRN---------------PNITSSSSDTKIAKRMAMLIFTDFLCMAPIS 589
Cdd:cd15104 156 FHPRVLLVLSCMVFFpALLLFVFCYCDILKIARVhsraiykvehalarqIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQ 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   590 FFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15104 236 ITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
371-637 6.68e-09

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 57.82  E-value: 6.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVDVhtkteYHNYAIDWQTG-AGCDAAGFFT 449
Cdd:cd14977   9 VIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDL---LLLLLCVPLNA-----YNLLTKDWLFGdVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLE----CKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVS---IClPMDI 522
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQtigaCLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSsltVC-IMKP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLY-------VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSD-TKIAKRMAMLIFTDFLCMAPISF-FAI 593
Cdd:cd14977 160 STPFAETYpkarswwLFGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRGTKKhMKQRRQLAKTVLCLVLVFAFCWLpEHI 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   594 SASLKVPLIT---VSKSKILLVLFY------PINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14977 240 SNILRATLYNevlIDTRSTLDILDLigqflsFFNSCVNPIALYLLSEPFRRAF 292
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
374-634 7.09e-09

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 57.09  E-value: 7.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVIlITSQYKLTVPRFLMCNLAFADL--CIGIYLLLiasvdVHTKTEYHnyaidWQTG-AGCDAAGFFTV 450
Cdd:cd15115  12 LLGVPGNGLVIWV-AGLKMKRTVNTIWFLNLAVADLlcCLSLPFSI-----AHLLLNGH-----WPYGrFLCKLLPSIIV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIF---GISSYMKVSICLPMDIDSpls 527
Cdd:cd15115  81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCL-PVFiyrTTVTDGNHTRCGYDFLVA--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   528 qLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSdtKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKS 607
Cdd:cd15115 157 -ITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQS--KTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLM 233
                       250       260
                ....*....|....*....|....*....
gi 544349   608 KI--LLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15115 234 SWdhLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
367-630 1.02e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 57.06  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTGAG-CDAA 445
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAI--------WAYTVAWLAGNTmCKLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMqleCKVQLRHAASIML-VGWIFA--FAVALFPIFGISSYMKVSI---CLP 519
Cdd:cd15384  77 KYLQVFGLYLSTYITVLISLDRCVAILYPM---KRNQAPERVRRMVtVAWILSpiFSIPQAVIFHVERGPFVEDfhqCVT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPL--SQLYVM-SLLVLNVLAFVVICGCYTHIYLTV----------------RNPNITSSSSDTKI-AKRMAMLIF 579
Cdd:cd15384 154 YGFYTAEwqEQLYNMlSLVFMFPIPLVIMVTCYVLIFITLskssrdfqgleiytrnRGPNRQRLFHKAKVkSLRMSAVIV 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   580 TDF-LCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFT 630
Cdd:cd15384 234 TAFiLCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIYGAFH 285
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
364-637 1.10e-08

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 56.50  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQyKLTVP-RFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTG-AG 441
Cdd:cd15334   2 LISLTLSILALMTTAINSLVITAIIVTR-KLHHPaNYLICSLAVTDFLVAVLVMPFSIMYIVKET--------WIMGqVV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMD 521
Cdd:cd15334  73 CDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECIIK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLNVLAFVVICgcYTHIYltvrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPisFFA---ISASLK 598
Cdd:cd15334 153 HDHIVFTIYSTFGAFYIPLALILIL--YYKIY--------RAATRERKAATTLGLILGAFVICWLP--FFVkevIVNTCD 220
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   599 VPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15334 221 SCYISEEMSNFLTWLGY-INSLINPLIYTIFNEDFKKAF 258
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
367-637 1.14e-08

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 56.59  E-value: 1.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIyllLIASVDVHTktEYHNYaiDWQTGAG-CDAA 445
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAI---LVMPFAVYV--EVNGG--KWYLGPIlCDIY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGI--SSYMKVSICLPMDID 523
Cdd:cd15053  78 IAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLnnVPYRDPEECRFYNPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 ----SPLSQLYVMSLLVLNVlafvvicgcYTHIYLTVRNpnitssssDTKIAKRMAMLIFTDFLCMAPisFF------AI 593
Cdd:cd15053 158 fiiySSISSFYIPCIVMLLL---------YYRIFRALRR--------EKKATKTLAIVLGVFLFCWLP--FFtlnilnAI 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   594 SASLKVPLITVSKSKILLVLF--YpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15053 219 CPKLQNQSCHVGPALFSLTTWlgY-VNSFLNPIIYTIFNIEFRKAF 263
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
364-635 1.37e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 56.58  E-value: 1.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADL---CIGIYLLLIASVDVHtkteyhnyaidWQTGA 440
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDIlitLLNTPFTLVRFVNST-----------WVFGK 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 G-CDAAGFFTVFASELSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAVAL--------FPIFgISSY 511
Cdd:cd15389  71 ImCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHP--LKPRITPCQGVVVIAIIWIMASCLSLphaiyqklVEFE-YSNE 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   512 MKVSICLPmDIDSPlSQLYVMSL-----LVLNVLAFVVICGCYTHIY--LTVRNpNITSSSSDTKIAKR--------MAM 576
Cdd:cd15389 148 RTRSRCLP-SFPEP-SDLFWKYLdlatfILQYVLPLLIIGVAYTRVAkkLWLRN-AIGDVTTEQYVAQRrkkkktikMLM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544349   577 LIFTDF-LCMAPISFFAISASLKvpliTVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRR 635
Cdd:cd15389 225 LVVLLFaICWLPLNCYHVLLSSH----PIRSNSALFFAFHWLamsSTCYNPFIYCWLNDSFRS 283
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
364-637 1.43e-08

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 56.28  E-value: 1.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADL--CI-GIYLLLIASVDVHtkteyhnyaidWQTG- 439
Cdd:cd15086   2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLlvCVlGTPFSFAASTQGR-----------WLIGe 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKvQLRHAASIMLVGWIFAFAVALFPIFGISSY----MKVS 515
Cdd:cd15086  71 HGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPTEADVS-DYRKAWLGVGGSWLYSLLWTLPPLLGWSSYgpegPGTT 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTD----FLCMAPISF 590
Cdd:cd15086 150 CSVQWTSRSANSISYIICLFIFClLLPFLVMVYCYGRLLYAIKQVGKINKSTARKREQHVLLMVVTMvicyLLCWLPYGV 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   591 FAISASLKVP-LITVSKSKILLVLFYPINSCaNPFLYAIFTKNFRRDF 637
Cdd:cd15086 230 MALLATFGKPgLVTPVASIVPSILAKSSTVV-NPIIYVFMNKQFYRCF 276
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
371-635 1.80e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 56.17  E-value: 1.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYL-LLIasvdvhtkteyHNYAI--DWQTG-AGCDAAG 446
Cdd:cd15168   9 VVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLpFLI-----------YYYANgdHWIFGdFMCKLVR 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVS--ICLPMDIDS 524
Cdd:cd15168  78 FLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNrtTCYDTTSPE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQ--LYVMSLLVLN-VLAFVVICGCYTHIYLTV--RNPNITSSSSDTKIAKRMAMLIFTDFLCMAPisfFAI--SASL 597
Cdd:cd15168 158 ELNDyvIYSMVLTGLGfLLPLLIILACYGLIVRALirKLGEGVTSALRRKSIRLVIIVLALFAVCFLP---FHVtrTINL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   598 KVPLITVSKSKILLVLFY----------PINSCANPFLYAIFTKNFRR 635
Cdd:cd15168 235 AARLLSGTASCATLNGIYvaykvtrplaSLNSCLNPLLYFLAGDKFRR 282
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
371-642 1.82e-08

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 56.41  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILV-------LVILITSQYK-LTVP-RFLMCNLAFADLCIGIYllliasvdvHTKTEYHNYAIDWQT--G 439
Cdd:cd15084  10 YLTVAVLMGMVVAlasfvngLVIVVSIKYKkLRSPlNYILVNLAVADLLVTLF---------GSSVSFSNNIVGFFVfgK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSI--- 516
Cdd:cd15084  81 TMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMG-DFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLrts 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLP-MDIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNITSSSSDT-----KIAKRMAMLIFTDFL-CMAPI 588
Cdd:cd15084 160 CGPnWYTGGTNNNSYILALFVTCfALPLSTIIFSYSNLLLTLRAVAAQQKESETtqraeKEVTRMVIAMVMAFLiCWLPY 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   589 SFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLS 642
Cdd:cd15084 240 ATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLC 293
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
364-637 2.02e-08

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 55.96  E-value: 2.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhtkteyHNYAIDWQTGA--- 440
Cdd:cd15974   2 LIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLAT---------QNAISYWPFGSflc 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 ----GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSI 516
Cdd:cd15974  73 rlvmTVDGVNQFT------SIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVL-PVIIFSDVQPDLN 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSS----DTKIAKRMAMLIFTDFL-CMAP 587
Cdd:cd15974 146 TCNISWPEPVSVWSTAFIIYTAVLGFfgplLVICLCYLLIVIKVKSSGLRVGSTkrrkSERKVTRMVVIIVVVFVfCWLP 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   588 ---ISFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15974 226 fymLNIVNLIVILPEEPAFVGVYFFVVVLSY-ANSCANPILYGFLSDNFKQSF 277
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
363-637 2.20e-08

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 55.93  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLiasvdvhtKTEYHNYAIDWQTGAG- 441
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPF--------QIVYHIQRNHWIFGKPl 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CD--AAGFFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPI-----------FGI 508
Cdd:cd15368  73 CNvvTVLFYANMYS--SILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVL-TALSPLertdltyyvkeLNI 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   509 SSYMKV--SICLPmDIDSPLSQLYVMsLLVLNVLAFVVICGCYTHIYLT-VRNPNITSSSSDTKIAKRMAMLIFTDFLCM 585
Cdd:cd15368 150 TTCFDVlkWTMLP-NIAAWAAFLFTL-FILLFLIPFIITVYCYVLIILKlVQTSERYGREQKRRAIYLALIVLLVFITCF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   586 APISFFAISASlkVPLITVSKS-----KILLVLfYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15368 228 APNNFILLAHM--VSRLFYGKSlyhayKLTLSL-SCLNSCLDPFIYYFASKEFRKKL 281
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
364-637 2.36e-08

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 55.99  E-value: 2.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITS-QYKLTVPRFLMCNLAFADLCIGIYLL----LIASVDvhtkteyhnyaiDWQT 438
Cdd:cd15097   2 IVPVVFSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVpfqaTIYSLE------------GWVF 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   439 GAG-CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFA--FAVALFPIFGISSYMKVS 515
Cdd:cd15097  70 GSFlCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSllFAGPYLSYYDLIDYANST 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHI--YL-TVRNPniTSSSSDTKIAKRMA---MLIFTDFLCMAPIS 589
Cdd:cd15097 150 VCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTikYLwTAVDP--LEAMSESKRAKRKVtkmIIIVTALFCLCWLP 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   590 FFAISASL---KVPLITVSKS-KILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15097 228 HHVVILCYlygDFPFNQATYAfRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
364-637 2.56e-08

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 55.71  E-value: 2.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIdwqtgagCD 443
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLF-------CK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGW----IFAFAVALFPIFGISSYMKVSICLP 519
Cdd:cd15314  75 IHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWsvsaLVGFGIIFLELNIKGIYYNHVACEG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDI--DSPLSQLyVMSLLVLNVLAFVVICgCYTHIYLTVR-----------NPNITSSSSDTKIAKRMAMLIFTDFLCMA 586
Cdd:cd15314 155 GCLvfFSKVSSV-VGSVFSFYIPAVIMLC-IYLKIFLVAQrqarsiqsartKSGASSSKMERKATKTLAIVMGVFLLCWT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   587 PiSFFAISAslkVPLITVSKSKIL---LVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15314 233 P-FFLCNII---DPFINYSIPPVLievLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
369-634 2.73e-08

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 55.68  E-value: 2.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   369 IWFISILAITGNILVLVILITSQYK-LTVP-RFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYAIDWQtgAGCDAAG 446
Cdd:cd15081  17 VWMIFVVFASVFTNGLVLVATLKFKkLRHPlNWILVNLAIADLGETVIASTISVVN-----QIFGYFILGH--PMCVLEG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----MKVSiCLPmDI 522
Cdd:cd15081  90 FTVSVCGITGLWSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYwphgLKTS-CGP-DV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 ----DSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVR------NPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFF 591
Cdd:cd15081 167 fsgsSDPGVQSYMIVLMITCcIIPLAIIILCYLQVWLAIRavaqqqKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFF 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 544349   592 AISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15081 247 ACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
371-634 2.75e-08

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 55.66  E-value: 2.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVlvILITSQYK--LTVPRFLMCNLAFADLCIgiylLLIASVDVHTKTEYHnyaiDWQTGAG-CDAAGF 447
Cdd:cd15131   9 LLFVVGVTGNLMT--MLVVSKYRdmRTTTNLYLSSMAFSDLLI----FLCMPLDLYRLWQYR----PWNFGDLlCKLFQF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAlFPIFGISSYMKVSICLPMDIDSPLS 527
Cdd:cd15131  79 VSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSA-GPIFVLVGVEHENGTNPIDTNECKA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   528 QLYVMSLLVLNVLA------FVVICGCYTHIYLTV-------RNPNITSSSS-----DTKIAKRMAMLIFTDFLCMAPIS 589
Cdd:cd15131 158 TEYAVRSGLLTIMVwvssvfFFLPVFCLTVLYSLIgrklwrrRRENIGPNAShrdknNRQTVKMLAVVVFAFVLCWLPFH 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   590 ----FFAIS---ASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFR 634
Cdd:cd15131 238 vgryLFSKSfeaGSLEIALISQYCNLVSFVLFY-LSAAINPILYNIMSKKYR 288
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
364-637 2.82e-08

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 55.47  E-value: 2.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVdVHTKTEYHNYAIDWQTG-AGC 442
Cdd:cd14995   2 VATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADL-----MVLVAAG-LPNEIESLLGPDSWIYGyAGC 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF-------------GIS 509
Cdd:cd14995  76 LLITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFlldlsikhygddiVVR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   510 SYMKVSICLPMDIdsplsqlYVMSLLVLNVLAFVVICGCYTHIyltvrnpNITSSSSDTKIAKRMAMLIFTDFLCMAP-- 587
Cdd:cd14995 156 CGYKVSRHYYLPI-------YLADFVLFYVIPLLLAIVLYGLI-------GRILFSSRKQVTKMLAVVVVLFALLWMPyr 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   588 ----ISFFAISASLKVPLITVSKSKILlvlfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd14995 222 tlvvYNSFASPPYLDLWFLLFCRTCIY------LNSAINPILYNLMSQKFRAAF 269
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
368-637 2.88e-08

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 55.34  E-value: 2.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteYHNYAIDWQTG-AGCDAAG 446
Cdd:cd15328   6 LLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV-------HELSGRRWQLGrSLCQVWI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPI-FG-------ISSYMKVSICL 518
Cdd:cd15328  79 SFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLlFGwgetyseDSEECQVSQEP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYvmslLVLNVLAFVvicgcYTHIYltvrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPisFFAisASLK 598
Cdd:cd15328 159 SYTVFSTFGAFY----LPLCVVLFV-----YWKIY--------KAAQKEKRAALMVGILIGVFVLCWIP--FFL--TELI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   599 VPLITVS-----KSkILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15328 218 SPLCSCDippiwKS-IFLWLGYS-NSFFNPLIYTAFNKNYNNAF 259
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
365-637 2.89e-08

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 55.34  E-value: 2.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYaidWQTG-AGCD 443
Cdd:cd15322   3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAN-----EVMGY---WYFGkVWCE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGI---SSYMKVSIClpm 520
Cdd:cd15322  75 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekkSGQPEGPIC--- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSplSQLYVMSLLVLNVLA-FVVICGCYTHIYLTVRNpnitsssSDTKIAKRMAMLIFTDFLCMAPISF---FAISAS 596
Cdd:cd15322 152 KIND--EKWYIISSCIGSFFApCLIMVLVYIRIYQIAKN-------REKRFTFVLAVVIGVFVICWFPFFFtytLTAVCD 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   597 LKVPLiTVSKskiLLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15322 223 CSVPE-TLFK---FFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
364-505 3.35e-08

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 55.54  E-value: 3.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILaitGNILVLV-ILITSQYKlTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTGA-G 441
Cdd:cd15058   5 LLLALIILAIVV---GNLLVIIaIARTSRLQ-TMTNIFITSLACADLVMGLLVVPLGATIVVTGK--------WQLGNfW 72
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPI 505
Cdd:cd15058  73 CELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPI 136
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
364-637 3.37e-08

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 55.39  E-value: 3.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlCIGIYLLLIASVDVHTKTeyhnyaidWQTG-AGC 442
Cdd:cd15090   2 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGT--------WPFGnILC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSICLPMDI 522
Cdd:cd15090  73 KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL-PVMFMATTKYRQGSIDCTL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAF------VVICGCYTHIYLTVRNPNITSSSSDT----KIAKRMAMLIFTDFL-CMAPISFF 591
Cdd:cd15090 152 TFSHPSWYWENLLKICVFIFafimpvLIITVCYGLMILRLKSVRMLSGSKEKdrnlRRITRMVLVVVAVFIvCWTPIHIY 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   592 AI-SASLKVP--LITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15090 232 VIiKALVTIPetTFQTVSWHFCIALGY-TNSCLNPVLYAFLDENFKRCF 279
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
371-637 3.65e-08

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 55.60  E-value: 3.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtkteyhNYAIDWQ-TGAGCDAAGFFT 449
Cdd:cd15981   9 FIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVD--------NLITGWPfDNAMCKMSGLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAF------AVAL--------FPIFGISSYMKVS 515
Cdd:cd15981  81 GMSVSASVFTLVAIAVERFRCIVHPFRQ--KLTLRKAIVTIVIIWVLALiimcpsAVTLtvtreehhFMVDDYNNSYPLY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLY---VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDT----KIAKRMAMLIftDFLCMAPI 588
Cdd:cd15981 159 SCWEAWPDTEMRKIYttvLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEeegrRVSKRKIKVI--NMLIIVAL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   589 sFFAISAslkVPLIT---------VSKSKILLVLFYPI---------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15981 237 -FFTLSW---LPLWTlmlltdyghLSEDQLNLVTVYVFpfahwlaffNSSVNPIIYGYFNENFRRGF 299
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
372-637 5.90e-08

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 54.81  E-value: 5.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiyLLLIASVDVhtKTEYHNYAIDWQTGagcDAAGFFTVF 451
Cdd:cd15921  10 IFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISD------LLLVCTLPL--RLTYYVLNSHWPFG---DIACRIILY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASEL----SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAvALFPIFGISSYMK---VSICL--PMDI 522
Cdd:cd15921  79 VLYVnmysSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGL-ASSPLLFAKSKQHdegSTRCLelAHDA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTD---FLCMAPIS-----FFAIS 594
Cdd:cd15921 158 VDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSRRKACALIIISLgifLVCFLPYHivrtiHLITE 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   595 ASLKVP---LITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15921 238 RQIKEScgyILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
365-637 5.93e-08

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 54.44  E-value: 5.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIW-FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIasvdvhtkTEYHNYAIDWQTG-AGC 442
Cdd:cd15979   2 VRILLYsVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPF--------TLIPNLMGTFIFGeVIC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFgissymKVSICLPMD 521
Cdd:cd15979  74 KAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIpYPVY------SVTVPVPVG 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQL-------------YVMSLLVLNVLAFVVICGCYTHIYLTVRNPNItsssSDTKIAKRMAMLIFTDFLCMAPI 588
Cdd:cd15979 148 DRPRGHQCrhawpsaqvrqawYVLLLLILFFIPGVVMIVAYGLISRELYRGLL----AKKRVIRMLVVIVAMFFLCWLPI 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   589 -------SFFAISASLKVPLITVSkskiLLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15979 224 fsantwrAFDPLSAHRALSGAPIS----FIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
372-637 6.24e-08

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 54.52  E-value: 6.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKteyHNYAIDWQTG-AGCDAAGFFTV 450
Cdd:cd15124  10 IILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDL-----LLLVTCAPVDAS---RYLADEWLFGrVGCKLIPFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLEC-----KVQLRhAASIMLVGWIFAFAVALF----PIFGISSYMKVSICLPMD 521
Cdd:cd15124  82 TSVGVSVFTLTALSADRYKAIVRPMDIQAsnalmKICLK-AALIWILSMLLAIPEAVFsdlhPFYDKSTNKTFVSCAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPL-SQLYVM-SLLVLNVLAFVVICGCYTHIY--LTVRNPNI-----TSSSSDTKIAKRMA--MLIFTDF--LCMAPI 588
Cdd:cd15124 161 HSNELhPKIHSMaSFLIFYVIPLSIISVYYYFIAknLIRSAYNLpvegnVHVRRQIESRKRLAktVLVFVGLfaFCWLPN 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   589 SFFAISASLKVPLITVSK----SKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15124 241 HIIYLYRSYHYSEVDTSMlhfvSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
364-637 6.24e-08

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 54.45  E-value: 6.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIasvdvhtkteYHNYAIDWQTGAGCD 443
Cdd:cd15295   2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPL----------YIPYTLTNRWDFGRG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASEL---SVYTLTAITLERWHTITHAMQLECK-VQLRHAASIMLVGWIFAFAVAlFPIFGISSYMKV--SIC 517
Cdd:cd15295  72 LCVFWLVIDYLLctaSVYNIVLISYDRYQSVSNAVSYRNQqTATLRIVTQMVAVWVLAFLVH-GPAILVSDSWKTedGEC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPmdidSPLSQLYVmsLLVLNVLAFVV--ICGCY--THIYLTVRnpnitSSSSDTKIAKRMAMLIFTDFLCMAPISFFAI 593
Cdd:cd15295 151 EP----EFFSNWYI--LAITSVLEFLVpvILVAYfnTQIYWSLW-----KRLRDRKLAKSLAIILGTFAICWAPYSLFTI 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   594 saslkvplITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15295 220 --------IRAACEKHRGSPWYNFafwlqwfNSFINPFLYPLCHKRFRKAF 262
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
371-635 7.78e-08

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 54.37  E-value: 7.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFAD-LCIGIYLLLIAsvdvhtkteYHNYAIDWQTG-AGCDAAGFF 448
Cdd:cd15158   9 VITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDlLCVCTLPLRVV---------YYVHKGQWLFGdFLCRISSYA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFPIFGISSYMKV---SICL-PMDIDS 524
Cdd:cd15158  80 LYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFV-TLTSSPFLMSGSHDTEtnkTKCFePPQSNQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVM---SLLVLNVLAFVVICGCYTHIYLTV--RNPNITSSSSDTKIAKRMAMLIFTDFL-CMAP--------ISF 590
Cdd:cd15158 159 QLTKLLVLnyiSLVVGFIIPFLVILICYAMIIRTLlkNTMKARKQQSSRKKAIRMIIIVLLAFLvSFMPyhiqrtihLHF 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15158 239 LSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
367-636 9.22e-08

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 53.93  E-value: 9.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLL-LIASVDvhtkteYHNYAIDWQTGAG-CDA 444
Cdd:cd15160   5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDL---LYILtLPLWID------YTANHHNWTFGPLsCKV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIF---AFAVALFPIFGISSYMKVSICLPM- 520
Cdd:cd15160  76 VGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLelgTHSVFLGHDELFRDEPNHTLCYEKy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAP---ISFFAISASL 597
Cdd:cd15160 156 PMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPyhvVLLVRSVIEL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   598 KVPLITVSKSKI-----LLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15160 236 VQNGLCGFEKRVftayqISLCLTSLNCVADPILYIFVTEDVRQD 279
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
372-634 9.69e-08

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 54.01  E-value: 9.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdVHTKTEYHNYAidwqtgagCDAAGFFTVF 451
Cdd:cd15070  10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIV-VSLGVTIHFYS--------CLFMSCLLVV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG----ISSYMKVSICLPMDIDS--P 525
Cdd:cd15070  81 FTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGwnrkPSLESVNTTPLQCQFTSvmR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSS----------DTKIAKRMAMLIFTDFLCMAPISF--FAI 593
Cdd:cd15070 161 MDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGfretgafygrEFKTAKSLALVLFLFAVCWLPLSIinCVV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   594 SASLKVPLITVskskILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15070 241 YFNPKVPKIAL----YLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
364-637 9.97e-08

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 53.65  E-value: 9.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTGA-GC 442
Cdd:cd15333   6 SLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGT--------WTLGQvVC 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF--GISSYMKVSIC--- 517
Cdd:cd15333  78 DIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFwrQAKAEEEVSECvvn 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 ---LPMDIDSPLSQLYVMSLLVLNVlafvvicgcYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPisFFAIs 594
Cdd:cd15333 158 tdhILYTVYSTVGAFYIPTLLLIAL---------YGRIYVEAR-------ARERKATKTLGIILGAFIVCWLP--FFII- 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   595 aSLKVPlITVSKSKILLVLF------YPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15333 219 -SLVLP-ICKDACWFHLAIFdfftwlGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
374-635 1.06e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 53.79  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITS--QYKLTVPRFLMCNLAFADLCiGIYLLLIASVDVHTKTEyhnyaiDWQTG-AGCDAAGFFTV 450
Cdd:cd14981  12 VFGVLGNLLALIVLARSskSHKWSVFYRLVAGLAITDLL-GILLTSPVVLAVYASNF------EWDGGqPLCDYFGFMMS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAAsIMLVG-WIFAFAVALFPIFGISSYMKV---SICLPMDIDSPL 526
Cdd:cd14981  85 FFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRAR-LMLGAvWAFALLIASLPLLGLGSYVLQypgTWCFLDFYSKNT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQL---YVMSLLVLNVLAFVVICGCYThIYLTVRNPNITSSSSDTKIAKR------MAMLIFTDFL------CMAPISFF 591
Cdd:cd14981 164 GDAayaYLYSILGLLILLVTLLCNLLV-IITLLRMRRRKKRHRRSRRSARrqkrneIQMVVLLLAItvvfsvCWLPLMIR 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   592 AISASLKvPLITVSKSKILLVLFYPINSCANPFLYAIFTK-NFRR 635
Cdd:cd14981 243 VLINATG-DSEKNGKTDLLAVRMASWNQILDPWVYILLRKeVLRR 286
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
371-637 1.32e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 53.89  E-value: 1.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASV-DVHTKTEY-HNYAIDWQTgagcdaagfF 448
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVnDLLGYWLFgETFCNIWIS---------F 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF-GISSYMKVSICLPMDIDSPLS 527
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlGWHRLSQDEIKGLNHASNPKP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   528 QLYvMSL-----LVLNVLAFVVIC----GCYTHIYLTVR------------------NPNITSSS-------SDTKIAKR 573
Cdd:cd15065 159 SCA-LDLnptyaVVSSLISFYIPClvmlLIYSRLYLYARkhvvniksqklpsesgskFQVPSLSSkhnnqgvSDHKAAVT 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   574 MAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15065 238 LGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGY-FNSCLNPIIYSIFNSEFRRAF 300
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
372-634 1.38e-07

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 53.65  E-value: 1.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVDVHTKTEYhnyaiDWQTGAG-CDAAGFFTV 450
Cdd:cd15380  10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDL---VFVLGLPFWAENIRNQF-----NWPFGNFlCRVISGVIK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSY-----MKVSICLpmdIDSP 525
Cdd:cd15380  82 ANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSI-PTFLFRSVkhvpdLNISACI---LLFP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSS-----DTKiAKRMAMLIFTDFL-CMAPISFFAISA 595
Cdd:cd15380 158 HEAWHFARRVELNIVGFllplAAIVFFNFHIIASLRERTEESRKRcgglkDTK-ATRLILTLVLMFLvCWTPYHFFAFLD 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   596 SL-KVPLIT-------VSKSKILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15380 237 FLfQVEVIQgcfweefIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
367-626 1.42e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 53.20  E-value: 1.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTkteyhnYAIDWqTGAGCDAAG 446
Cdd:cd14964   3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLT------EASSR-PQALCYLIY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGIssYMKVSICLPMDIDSPL 526
Cdd:cd14964  76 LLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGK--GAIPRYNTLTGSCYLI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQLYVMSLLVLNVLAFVVICGC--------YTHIYLTVRNPNITSSSSDT--KIAKRMAMLIFTDFLCMAPISFFAISAS 596
Cdd:cd14964 154 CTTIYLTWGFLLVSFLLPLVAFlvifsrivLRLRRRVRAIRSAASLNTDKnlKATKSLLILVITFLLCWLPFSIVFILHA 233
                       250       260       270
                ....*....|....*....|....*....|
gi 544349   597 LKVPLITVSKSKILLVLFYPINSCANPFLY 626
Cdd:cd14964 234 LVAAGQGLNLLSILANLLAVLASTLNPFIY 263
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
367-637 1.43e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 53.65  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFIS---ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtktEYHNYaidWQTGAG-C 442
Cdd:cd15056   2 VLSTFLSlviLLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIE-----LVNNR---WIYGETfC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTIThAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF------GISSYMKVSI 516
Cdd:cd15056  74 LVRTSLDVLLTTASIMHLCCIALDRYYAIC-CQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMqgwnhiGIEDLIAFNC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLpmdiDSPLSQLYVMS--LLVLNVLAF----VVICGCYTHIYLTVR----------NPNITSSSSD----------TKI 570
Cdd:cd15056 153 AS----GSTSCVFMVNKpfAIICSTVAFyipaLLMVLAYYRIYVAAReqahqirslqRAGSSNHEADqhrnsrmrteTKA 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   571 AKRMAMLIFTDFLCMAPisFFAisASLKVPLITVSKS----KILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15056 229 AKTLGIIMGCFCVCWAP--FFV--TNIVDPFIGYRVPyllwTAFLWLGY-INSGLNPFLYAFFNKSFRRAF 294
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
364-637 1.43e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 53.36  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigiyLLLIASVDVHTKT-EYHNYaidWQTG-AG 441
Cdd:cd15325   2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVAD------LLLTSTVLPFSAIfEILGY---WAFGrVF 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSymkvsiclPMD 521
Cdd:cd15325  73 CNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKE--------PAP 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQL-----YVM-SLLVLNVLAFVVICGCYTHIYLTVrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPIsFFAISA 595
Cdd:cd15325 145 EDETICQIteepgYALfSALGSFYLPLAIILVMYCRVYVVA-----LKFSREKKAAKTLGIVVGCFVLCWLPF-FLVMPI 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   596 SLKVPLITVSKS--KILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15325 219 GSIFPAYKPSDTvfKITFWLGY-FNSCINPIIYPCSSQEFKKAF 261
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
364-637 1.79e-07

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 53.13  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhtkteYHNYaiDWQTGA-GC 442
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWAS--------YHSS--GWIFGEiLC 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAG--FFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMK----VSI 516
Cdd:cd15182  72 KAVTsiFYIGFYS--SILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISI-LASLPELILSTVMKsdedGSL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLnvLAFVVICGCYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISAS 596
Cdd:cd15182 149 CEYSSIKWKLGYYYQQNLFFL--IPLGIIVYCYVRILQTLMR---TRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRS 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   597 LK-VPLITVSKSKILLVLFYPINS------CANPFLYAIFTKNFRRDF 637
Cdd:cd15182 224 LKdLTIPICECSKQLDYAFYICRNiafshcCLNPVFYVFVGVKFRNHL 271
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
375-637 1.86e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 53.39  E-value: 1.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   375 LAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKteyHNYAIDWQTG-AGCDAAGFFTVFAS 453
Cdd:cd15123  13 VGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDL-----LLLLTCVPVDAT---RYIADTWLFGrIGCKLLSFIQLTSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   454 ELSVYTLTAITLERWHTITHAMQLECKVQLRH----AASIMLVGWIFAFAVALFP-IFGISS---YMKVSICLPMDIDSP 525
Cdd:cd15123  85 GVSVFTLTVLSADRYRAIVKPLELQTSDAVLKtcckAGCVWIVSMLFAIPEAVFSdLYSFRDpekNTTFEACAPYPVSEK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLY--VMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSS-----------SDTKIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd15123 165 ILQEIhsLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMPAeehsharkqieSRKRVAKTVLVLVALFAFCWLPNHILY 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   593 ISASLKV-PLITVSKSKILLVLFYPI----NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15123 245 LYRSFTYhTSVDSSAFHLIATIFSRVlafsNSCVNPFALYWLSKSFRQHF 294
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
364-635 1.99e-07

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 52.86  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNilVLVILITSQYK-LTVP-RFLMCNLAFADLciGIYLLLIASVDVHTKTEYHNYAidwqtGAG 441
Cdd:cd15075   2 ILSIIMAVFSIASVVLN--ATVIIVTLRHKqLRQPlNYALVNLAVADL--GTTVFGGLLSVVTNAVGYFNLG-----RVG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSI---CL 518
Cdd:cd15075  73 CVLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVmtsCA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PmDIDS--PLSQLYVMS-LLVLNVLAFVVICGCYTHIYLTVR-------NPNITSSSSDTKIAKRMAMLIFTDFLCMAPI 588
Cdd:cd15075 152 P-DWYSrdPVNVSYILCyFSFCFAIPFAIILVSYGYLLWTLRqvaklgvAEGGSTAKAEVQVARMVVVMVMAFLLCWLPY 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 544349   589 SFFAisaslkvpLITVSKSKI---LLVLFYPI-----NSCANPFLYAIFTKNFRR 635
Cdd:cd15075 231 AAFA--------LTVVSKPDVyinPLIATVPMylaksSTVYNPIIYIFMNKQFRD 277
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
364-635 2.14e-07

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 52.89  E-value: 2.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKlTVPRFLMCNLAFADLC--IGIYLLLiasvdvhtkteyHNYAIDWQTGAG 441
Cdd:cd15339   2 ILPSFIGILCSTGLVGNILVLFTIIRSRKK-TVPDIYVCNLAVADLVhiIVMPFLI------------HQWARGGEWVFG 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 ---CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAlFPIFGISSYMK----V 514
Cdd:cd15339  69 splCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILV-LPVWVYAKVIKfrdgL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   515 SICLpMDIDSPLSQLYVMslLVLNVLAFV----VICGCYT----HIYLTVRNpNITSSSSDTKIAKRMAMLIFTdfLCMA 586
Cdd:cd15339 148 ESCA-FNLTSPDDVLWYT--LYQTITTFFfplpLILICYIlilcYTWEMYRK-NKKAGRYNTSIPRQRVMRLTK--MVLV 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   587 PISFFAISAS----LKVPLITVSKSKILLVLFYPIN-------SCANPFLYAIFTKNFRR 635
Cdd:cd15339 222 LVGVFLVSAApyhvIQLVNLSVSQPTLAFYVSYYLSiclsyasSSINPFLYILLSGNFRK 281
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
371-637 2.48e-07

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 52.51  E-value: 2.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGI-YLLLIASVDVHTKTEYHNyaiDWQTGAGcdaagfft 449
Cdd:cd15101   9 TVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLaYFFLMFNTGPNTRRLTVS---TWFLRQG-------- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASEL--SVYTLTAITLERwHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMdidSPL- 526
Cdd:cd15101  78 LLDTSLtaSVANLLAIAVER-HISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNM---APLy 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQLYVMSLLVLNVLAFVVICGCYTHIYLTVRN-PNITSSSSDTKIAKRMAML--------IFTDFL-CMAP---ISFFAI 593
Cdd:cd15101 154 SRSYLVFWAISNLVTFLVMVVVYARIFVYVRRrTNRMSPHTSGSIRNRDTMMsllktvviVLGAFVvCWTPglvVLLLDG 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   594 SASLKVPLITVSKSKILLVLFypiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15101 234 LCCRQCNVLAVEKFFLLLAEF---NSAVNPIIYSYRDKEMSGTF 274
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
370-635 2.84e-07

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 52.59  E-value: 2.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   370 WFIsILAITG------NILVLVILITSQyKLTVPRF-LMCNLAFADLCIGIYLLLIASVdvhtkteyhNYAIDWQTGAGC 442
Cdd:cd15960   3 WDI-ALCVTGtvmaceNAIVIAILFYTP-SLRAPMFiLIGSLALADLLAGLGLIANFVA---------IYVMNSEAVTLC 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIClpmDI 522
Cdd:cd15960  72 SAGLLLAAFSA--SVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLRAPASC---SV 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLAFVVICGCYTHI---------YLTVRN--PNITSSSSDTKIAKRMAMLIFTDFLCMAPISFF 591
Cdd:cd15960 147 LRPVTKNNAAVLAVSFLLLFALMMQLYLQIcriafrhaqQIAVQHqfVNFCLASSTRKGVSTLSLILATFAFCWVPFAVY 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   592 AISASLKVPLITVskskILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15960 227 SMVADSSYPMIYT----YYLVLPAACNSVINPIIYAFRNPDIQK 266
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
376-637 2.85e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 52.29  E-value: 2.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   376 AITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTG-AGCDAAGFFTVFASE 454
Cdd:cd15330  14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL--------YQVLNKWTLGqVTCDLFIALDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   455 LSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISS--------YMKVSICLPMDIDSPL 526
Cdd:cd15330  86 SSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTpedrsdpdACTISKDPGYTIYSTF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQLYVMSLLVLnVLafvvicgcYTHIYltvrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPisFFAISASLKVPLITVSK 606
Cdd:cd15330 166 GAFYIPLILML-VL--------YGRIF--------KAAARERKTVKTLGIIMGTFILCWLP--FFIVALVLPFCESTCHM 226
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   607 SKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15330 227 PELLGAIINWLgysNSLLNPIIYAYFNKDFQSAF 260
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
363-637 2.99e-07

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 52.51  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGiyLLLIASVDVHTKTEYHNYAIDWQTGAGc 442
Cdd:cd15347   1 QVASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAG--VAFIANILLSGSVTFRLTPVQWFIREG- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 daAGFFTVFASelsVYTLTAITLERWHTIThamQLECKVQLRHAASIMLVG--WIFAFAVALFPIFG---ISSYMKVSIC 517
Cdd:cd15347  78 --TAFITLSAS---VFSLLAIAIERHVAIT---KVKLYGSDKNCRMVLLIGacWVISIVLGGLPILGwncIGNLEDCSTV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMDidSPLSQLYVMSLLVLNVLAFVVIcgcYTHIYLTVRNPNITSSSSDT-KIAKRMAMLIFTDFLCMAP-ISFFAISA 595
Cdd:cd15347 150 LPLY--SKHYILFVVTIFSIILLSIVIL---YVRIYCIVRSSHAEMAAPQTlALLKTVTIVLGVFIVCWLPaFIILLLDT 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 544349   596 SLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15347 225 SCKVKSCPILYKADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
367-637 3.16e-07

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 52.15  E-value: 3.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVDVHTKTeyhnyAIDWQTGAG-CDAA 445
Cdd:cd15215   4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADL---LQTVLVMPWVIATSV-----PLFWPLDSHlCTAL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFG---ISSYMKVSICLPMDI 522
Cdd:cd15215  76 VVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGwgqAAFDERNALCSVIWG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPlsQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNpnitssSSDTKIAKRMAMLIFTDFLCMAPISFF---AISASLKV 599
Cdd:cd15215 156 SSY--SYTILSVVSSFVLPVIIMLACYSMVFRAARR------CYHCKAAKVIFIIIFSYVLSMGPYSFLsvlAVWVDTQV 227
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   600 PLITVSkskILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15215 228 PQWVIS---IILWLFF-LQCCIHPYIYGYMHKSIKKEF 261
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
374-636 3.43e-07

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 52.52  E-value: 3.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTeyhnyaidWQTGAG-CDAAGFFTVFA 452
Cdd:cd15391  12 FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH--------WVFPAPmCPIVLYVQLVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQleCKVQLRHAASIMLVGWIFAFAVALFPIFG--ISSYMKVS----IC---LPMDID 523
Cdd:cd15391  84 VTASVLTNTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLSSVQLFAgrTQRYGQYSegrvLCgesWPGPDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 S-PLSQLYVMslLVLNVLAFVVICGCYTHIYLTVRNPNITSSS----------SDTKIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd15391 162 SrSAYTVFVM--LLTYIIPLLILTSTYGYVGFRLWNRTAPGNAdkgrddmqikSKRKVIKMLVFVVLMFGICWLPLHLFN 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   593 ISASLKVPLITVSKSKILLVLFYPI-----NSCANPFLYAIFTKNFRRD 636
Cdd:cd15391 240 LVQDFSTVFRNMPQHTTRLIYGACHwiamsNSFVNPIIYLFMNDSFRSI 288
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
371-635 3.57e-07

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 52.47  E-value: 3.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYL-LLIAsvdvhtkteyhNYAID--WQTGA-GCDAAG 446
Cdd:cd15968   9 FVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLpLLIY-----------NYAMRdrWLFGDfMCRLVR 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIF-----GISSYMKVSICLPMD 521
Cdd:cd15968  78 FLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTL-PILifartGIIRNRTVCYDLAPP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTV-RNPNITSSSSDTKIAK--RMAMLIFTDF-LCMAPIS-----FF 591
Cdd:cd15968 157 ALFPHYVPYGMALTVSGfLLPFSIILWCYCLVVRTLcRTLGPAEPPAQARRRKsiRTIVTVTLLFaLCFLPFHitrtiYL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 544349   592 AISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRR 635
Cdd:cd15968 237 AVRVTPGVPCHVLEAVAACYKITRPLasaNSVLNPLLYFLTKKKFGR 283
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
456-637 4.03e-07

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 52.09  E-value: 4.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   456 SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGIS----SYMKVSIC-----LPMDIDSPL 526
Cdd:cd15120  86 SVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSI-PYLAFRetrlDEKGKTICqnnyaLSTNWESAE 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQ---------LYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIakrMAMLIFTDFLCMAPisfFAISASL 597
Cdd:cd15120 165 VQasrqwihvaMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKV---MFTAVVSFFVCWLP---YHLHSGL 238
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 544349   598 K----VPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15120 239 VltrgRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
367-637 4.57e-07

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 51.79  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiylLLIASVDVHTKTEYHNYaidWQTG-AGCDAA 445
Cdd:cd15092   5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADT------LVLLTLPFQGTDIFLGF---WPFGnALCKTV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVG-WIFAFAVAL-FPIFGISSYMKVSICLPMDID 523
Cdd:cd15092  76 IAIDYYNMFTSTFTLTAMSVDRYVAICHPIK-ALDVRTPHKAKVVNVCiWALASVVGVpVMVMGSAQVEDEEIECLVEIP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFVV----ICGCYTHIYLTVRNPNITSSSSDT----KIAKRMAMLIFTDFL-CMAPISFFAIS 594
Cdd:cd15092 155 TPQDYWDPVFGICVFLFSFIIpvliISVCYSLMIRRLRGVRLLSGSKEKdrnlRRITRLVLVVVAVFVgCWTPIQIFVLA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   595 ASLKVPLITVSKSKIL---LVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15092 235 QGLGVQPSSETAVAILrfcTALGY-VNSSLNPVLYAFLDENFKACF 279
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
372-637 4.78e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 51.51  E-value: 4.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliaSVDVHTKTEYHNYaidWQTGA-GCDAAGFFTV 450
Cdd:cd15297  10 LSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVF-----SMNLYTLYTVIGY---WPLGPvVCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAV----ALFPIFGISSYMkvsiclpmdidSPL 526
Cdd:cd15297  82 VVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILwapaILFWQFIVGGRT-----------VPE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQLYVMSLLVLNVLAFVVICGCYTH-IYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCM-APISFFAISASLKVPLITV 604
Cdd:cd15297 151 GECYIQFFSNAAVTFGTAIAAFYLPvIIMTVLYWQISRASSREKKVTRTILAILLAFIITwTPYNVMVLINTFCASCIPN 230
                       250       260       270
                ....*....|....*....|....*....|...
gi 544349   605 SKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15297 231 TVWTIGYWLCY-INSTINPACYALCNATFKKTF 262
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
372-511 5.18e-07

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 51.68  E-value: 5.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVL-VILITSQYKLTVprfLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIdwqtgAGCDAAGFFTV 450
Cdd:cd15220   9 LDLTALVGNTAVMvVIAKTPHLRKFA---FVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGE-----AECRVYIFLSV 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY 511
Cdd:cd15220  81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSY 141
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
374-634 5.56e-07

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 51.63  E-value: 5.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCigiYLLLIAsvdvhTKTEYHNYAIDWQTGA-GCDAAGFFTVFA 452
Cdd:cd15161  12 ILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLS---YVLILP-----MRLVYHLSGNHWPFGEvPCRLAGFLFYLN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFPIFGISSYMK---VSICLPMDIDSPlSQL 529
Cdd:cd15161  84 MYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIV-TVAMAPLLVSPQTVEvnnTTVCLQLYREKA-SRG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   530 YVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKiAKRMAMLIFTDFL-CMAPISFFAISASLKVPLITVS-KS 607
Cdd:cd15161 162 ALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKDK-AIKMIILVLTIFLiCFVPYHISRYIYILSHNGAGAScSS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 544349   608 KILLVLFYPINSC-------ANPFLYAIFTKNFR 634
Cdd:cd15161 241 RRGLALANRITSCltclngaLDPVMYFFVAEKFR 274
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
374-561 6.33e-07

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 51.62  E-value: 6.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigIYLLLIASVDVHTKTEYHnyaidWQTGAG-CDAAGFFTVFA 452
Cdd:cd15967  12 VVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADL---LYLLTLPFLVVYYLKGRK-----WIFGQVfCKITRFCFNLN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMDIDSPLSQlYVM 532
Cdd:cd15967  84 LYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSNGTKCFDTTFNDYLES-YLT 162
                       170       180       190
                ....*....|....*....|....*....|....
gi 544349   533 SLLVLNVLAFV----VICGCYTHIYLTV-RNPNI 561
Cdd:cd15967 163 YSLGWTVTGFVipllIILGCYGHVVVVLcRNNNV 196
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
372-637 6.60e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 51.40  E-value: 6.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYAI---DWqtgaGC--DAAG 446
Cdd:cd15357  10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDL-----LVLLFGMPLEVYEMWSNYPFlfgPV----GCyfKTAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTV-FASELSVytlTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFA--FAVALFPIFGI-----------SSYM 512
Cdd:cd15357  81 FETVcFASILSV---TTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSvlFSIPNTSIHGIklqyfpngtliPDSA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   513 KVSICLPMDIDSPLSQlyVMSLLvLNVLAFVVICGCYTHIYLTVR----------NPNITSSSSDTkIAKRMAMLIFTDF 582
Cdd:cd15357 158 TCTVVKPLWIYNLIIQ--ITSLL-FYVLPMGVISVLYYLMGLKLRgdksleademNVNIQRPSRKS-VTKMLFVLVLVFA 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   583 LCMAPIS----FFAISASLKVPLITV-SKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15357 234 ICWAPFHvdrlFFSFVVEWTEPLANVfNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
372-637 7.31e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 51.08  E-value: 7.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQyKLTVP-RFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIdwqtgagCDAAGFFTV 450
Cdd:cd15335  10 ITILTTVLNSAVIAAICTTK-KLHQPaNYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFI-------CEIWLSVDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGiSSYMKVSICLPMDIDSPLSQLY 530
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFW-RNHHDANIPSQCIIQHDHVIYT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   531 VMSLLVLNVLAFVVICGCYTHIYltvrnpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKIL 610
Cdd:cd15335 161 IYSTFGAFYIPLTLILILYYRIY--------HAASRERKAARILGLILGAFILSWLPFFIKELIVGLSVMTVSPEVADFL 232
                       250       260
                ....*....|....*....|....*..
gi 544349   611 LVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15335 233 TWLGY-VNSLVNPLLYTSFNEDFKLAF 258
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
371-637 7.56e-07

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 51.43  E-value: 7.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDvhtkteyhNYAIDWQTGAG-CDAAGFFT 449
Cdd:cd15980   9 LIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLD--------NIIAGWPFGSTvCKMSGMVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAV----ALFPIFGISSYMKVSI--------- 516
Cdd:cd15980  81 GISVSASVFTLVAIAVDRFRCIVYPFKQ--KLTISTAVVIIVIIWVLAIAImcpsAVMLHVQEEKNYRVVLgsqnktspv 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 --CLPMDIDSPLSQLYVMSL---LVLNVLAFVVIcgCYTHIYLTV------------RNPNITSSSSDTKIAKRM---AM 576
Cdd:cd15980 159 ywCREDWPNQEMRKIYTTVLfanIYLAPLSLIVI--MYARIGITLfktamphtgkhnQEQRHVVSRKKQKVIKMLlivAL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   577 LIFTDFLCMAPISFFAISASLkvpliTVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15980 237 LFILSWLPLWTLMMLSDYANL-----SPNQLQIINIYIYPFahwlaffNSSVNPIIYGFFNENFRRGF 299
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
363-635 7.65e-07

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 51.37  E-value: 7.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   363 DILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCI---GIYLLLIASVDvhtkteyHNYAIDwqtG 439
Cdd:cd15078   1 ELLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsllGVTFTFMSCVR-------GRWVFD---V 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASImlvgWIFAFAVALFPIFGISSYM----KVS 515
Cdd:cd15078  71 AGCVWDGFSNSLFGIVSIMTLTVLAYERYIRVVHAKVVNFSWSWRAITYI----WLYSLAWTGAPLLGWNRYTlevhGLG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLV-LNVLAFVVICGCYTHIYLTVRN----------PNITSSSSDTKIAKRMAMLIFTDFLC 584
Cdd:cd15078 147 CSFDWKSKDPNDTSFVLLFFLgCLVVPLGIMAYCYGHILYEIRMlrsvedlqtfQVIKILKYEKKVAKMCLLMISTFLIC 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   585 MAP---ISFFAISASLKVPLITVSkskILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15078 227 WMPyavVSLLVTSGYSKLVTPTIA---IIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
366-637 7.81e-07

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 51.21  E-value: 7.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   366 RVLIWFI-SILAITGNILVLVILITSQYKLTVP-RFLMCNLAFADLCIgiyLLLIASVDVhtkteYHNYAIDWQTG-AGC 442
Cdd:cd15383   3 RVAVTFVlFVLSACSNLAVLWSATRNRRRKLSHvRILILHLAAADLLV---TFVVMPLDA-----AWNVTVQWYAGdLAC 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLeckVQLRHAASIML-VGWIFAFAVA-----LFPIFGISSYMKVSI 516
Cdd:cd15383  75 RLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAI---GSARRRNRIMLcAAWGLSALLAlpqlfLFHTVTATPPVNFTQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 C-----LPMDIDSPLSQLYVMSLLVLnvLAFVVICGCYTHIYLTVRNP----------NITSSSSDTKIAK------RMA 575
Cdd:cd15383 152 CathgsFPAHWQETLYNMFTFFCLFL--LPLLIMIFCYTRILLEISRRmkekkdsaknEVALRSSSDNIPKarmrtlKMT 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   576 MLIFTDF-LCMAPISFFAI----SASLKVPLITVSKSKILLvLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15383 230 IVIVSSFiVCWTPYYLLGLwywfSPEMLEQTVPESLSHILF-LFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
372-637 8.75e-07

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 51.27  E-value: 8.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCigiyLLLIASVDVHTKTEYHNYaidwQTGA-GCDAAGFFTV 450
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLL----TLLVCPWMFLVHDFFQNY----VLGSvGCKLEGFLEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMqlECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMK-------VSICLPMDID 523
Cdd:cd15000  81 SLLLASVLALCAVSYDRLTAIVLPS--EARLTKRGAKIVIVITWIVGLLLAL-PLAIYRSYRErqwknflETYCAENTQV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFVVIcgCYTHIYL--------TVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISA 595
Cdd:cd15000 158 LPIYWHVIITVLVWLPLGIMLI--CYSAIFWkldkyerrVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYR 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   596 SLKVPLITV--SKSKILLVLFYP------INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15000 236 YKLVPNDNTqnSVSGSFHILWFAskylmfLNAAVNPLIYGFTNENFRKAF 285
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
364-635 1.10e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 50.95  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVlvILITSQYK-LTVP-RFLMCNLAFADLCIGiylLLIASVDVHTKTEYHNYAIDWqtgaG 441
Cdd:cd15082  15 VLAALMFVVTSLSLAENFAV--MLVTFRFKqLRQPlNYIIVNLSVADFLVS---LTGGTISFLTNARGYFFLGVW----A 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSI---CL 518
Cdd:cd15082  86 CVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIgttCE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLS-QLYVMSLLVLN-VLAFVVICGCYTHIYLTVRNPNIT------SSSSDTKIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd15082 165 PNWYSGNMHdHTYIITFFTTCfILPLGVIFVSYGKLLQKLRKVSNTqgrlgnARKPERQVTRMVVVMIVAFMVCWTPYAA 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   591 FAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15082 245 FSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRK 289
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
367-637 1.28e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 50.60  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHtkteyhnYAIDWQ-TGAGCDAA 445
Cdd:cd15306   5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIL-------FEAMWPlPLVLCPIW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLEckvQLRHAASIML---VGWIFAFAVAL-FPIFGISSYMKVSICLPMD 521
Cdd:cd15306  78 LFLDVLFSTASIMHLCAISLDRYIAIKKPIQAS---QYNSRATAFIkitVVWLISIGIAIpVPIKGIETDVDNPNNITCV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVmslLVLNVLAFVVICGCYTHIY-LTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600
Cdd:cd15306 155 LTKERFGDFI---LFGSLAAFFTPLAIMIVTYfLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDS 231
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   601 LITVSKSKILLVLFYP--INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15306 232 CNQTTLQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAF 270
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
364-637 1.84e-06

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 50.05  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaiDWQTG-AGC 442
Cdd:cd15331   2 LTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQ--------HWFLGpEVC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAmqleCKVQLRHAASIML---VGWIFAFAVALFPIFG------ISSYMK 513
Cdd:cd15331  74 DMWISMDVLCCTASILHLVAIALDRYWAVTNI----DYIRRRTAKRILImiaVVWFVSLIISIAPLFGwkdeddLDRVLK 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   514 VSICLpmdidspLSQLY---VMSLLVLNVLAFVVICGCYTHIYLTVRNpnitssssDTKIAKRMAMLIFTDFLCMAPisF 590
Cdd:cd15331 150 TGVCL-------ISQDYgytIFSTVGAFYVPLLLMIIIYWKIYQAAKR--------ERKAARTLAIITGAFVVCWLP--F 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   591 FAIsaSLKVPLI-TVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15331 213 FLV--ALVMPFCgAWQISRFLESFFLWLgyfNSLLNPIIYTIFSPDFRGAF 261
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
367-637 2.43e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 49.52  E-value: 2.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVhtkteYHNYAidWQ-TGAGCDAA 445
Cdd:cd15305   5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAI-----LYDYA--WPlPRYLCPIW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAAsIMLVGWIFAFAVAL---FPIFGISSYMKV---SICLP 519
Cdd:cd15305  78 ISLDVLFSTASIMHLCAISLDRYVAIRNPIE-HSRFNSRTKA-MMKIAAVWTISIGIsmpIPVIGLQDDEKVfvnGTCVL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLVLNVLafvVICGCYThIYLTVRNPNITSSSSDTKIAKrmamLIFTDFLCM-APisfFAISASLK 598
Cdd:cd15305 156 NDENFVLIGSFVAFFIPLIIM---VITYCLT-IQVLQRQQAINNERRASKVLG----IVFFLFLIMwCP---FFITNILS 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   599 VPLITVSKSKIL------LVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15305 225 VLCKEACDQKLMeellnvFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
365-636 3.76e-06

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 48.98  E-value: 3.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhtkteyhNYAIDWQTGAG-CD 443
Cdd:cd15174   3 LPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWAT----------AASSGWVFGTFlCK 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSYMK---VSICLp 519
Cdd:cd15174  73 VVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFVWLLSTILsLPEILFSQSKEeesVTTCT- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSLLVLNV-----LAFVVICGCYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAIS 594
Cdd:cd15174 152 MVYPSNESNRFKVAVLALKVtvgffLPFVVMVICYTLIIHTLLQ---AKRFQKHKALKVIIAVVTVFVLSQLPYNSILLI 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 544349   595 ASLKVPLITVSK----------SKILLVLFYpINSCANPFLYAIFTKNFRRD 636
Cdd:cd15174 229 KTINAYNITITDcatsqnldiaGQVTQSIAF-LHSCLNPFLYVFVGVRFRKD 279
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
365-637 4.74e-06

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 48.92  E-value: 4.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHtkteyhnyaiDWQTGAG-CD 443
Cdd:cd15180   3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVH----------GWIFGTGlCK 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAG--FFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfP--IFGISSY---MKVSI 516
Cdd:cd15180  73 LAGavFKINFYC--GIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSI-PdfIFLEATKdprQNKTE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNV---LAFVVICGCYTHIYLTVRnpnitSSSSDTKIAKRMAM---LIFTDFLCMAPISF 590
Cdd:cd15180 150 CVHNFPQSDTYWWLALRLLYHIVgflLPLAVMVYCYTSILLRLL-----RSSQGFQKQRAIRVivaVVVVFFLCWTPYNI 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   591 FAISASLKVPLI---------TVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15180 225 ALLVDTLIDLSVldrncgtesRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
374-637 6.32e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 48.41  E-value: 6.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyllLIASVDVHTKTEYhnYAIDWQTG-------AGCDAAG 446
Cdd:cd15091  12 VVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADA-------LVTTTMPFQSTVY--LMNSWPFGdvlckivISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTvfaselSVYTLTAITLERWHTITHAMQ-LECKVQLRhAASIMLVGWIFAFAValfpifGISSYMKVSICLPMDIDSP 525
Cdd:cd15091  83 MFT------SIFTLTMMSVDRYIAVCHPVKaLDFRTPLK-AKIINICIWLLSSSV------GISAIVLGGTKVREDVDST 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQL-----------YVMSLLVLnVLAFVV----ICGCYTHIYLTVRNPNITSSSSDT-----KIAKRMAMLIFTDFLCM 585
Cdd:cd15091 150 ECSLqfpdddyswwdTFMKICVF-IFAFVIpvliIIVCYTLMILRLKSVRLLSGSREKdrnlrRITRLVLVVVAVFVVCW 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   586 APISFFAISASLkvplITVSKSKILLVLFY------PINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15091 229 TPIHIFILVEAL----GSVSHSTAAVSSYYfcialgYTNSSLNPILYAFLDENFKRCF 282
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
380-634 6.69e-06

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 48.21  E-value: 6.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   380 NILVLVILITSQYKLTVPRFLMcNLAFADLcigiyLLLIAsvdVHTKTEYHNYAIDWQTGAG-CDAAGFFTVFASELSVY 458
Cdd:cd15372  18 NGLALWVLATQVKRLPSTIFLI-NLAVADL-----LLILV---LPFKISYHFLGNNWPFGEGlCRVVTAFFYGNMYCSVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   459 TLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY----MKVSIC---LPMDIDSPLSQLYV 531
Cdd:cd15372  89 LLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYplerLNITLChdvLPLDEQDTYLFYYF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   532 MSLLVLN-VLAFVVICGCYTHIYLTVrnpnITSSSSDTKIAKRMAMLIFTDFLCMAPISFfaisaslkVPLITVSKSK-- 608
Cdd:cd15372 169 ACLAVLGfLLPLVVILFCYGSVLHTL----LRSGQRYGHAMKLTVLVLVSFVLCFTPSNL--------LLLLHYSDPTld 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   609 ---------ILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15372 237 dggnlyivyMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
364-637 6.91e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 48.25  E-value: 6.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIasvdvhtkteYHNYAI--DWQTGAG 441
Cdd:cd15296   2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPL----------YIPYVLtgRWKFGRG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 -CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLEC-KVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLP 519
Cdd:cd15296  72 lCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRAqKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIPE 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPL--SQLYVMSLLVLNVLA-FVVICGCYTHIYLTVRNPNItSSSSDTKIAKRMAMLIFTDFLCMAPISFFA-ISA 595
Cdd:cd15296 152 GECYAEFfyNWYFLMTASTLEFFTpFISVTYFNLSIYLNIQKRRF-RLSRDKKVAKSLAIIVCVFGLCWAPYTLLMiIRA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 544349   596 SLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15296 231 ACHGHCVPDYWYETSFWLLW-VNSAINPVLYPLCHMSFRRAF 271
LRR_8 pfam13855
Leucine rich repeat;
72-132 8.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349      72 LEKIEISQNDvLEVIEANVFSNLPKLHEIRIEKaNNLLYIDPDAFQNLPNLRYLLISNTGI 132
Cdd:pfam13855   3 LRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSN-NLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
371-511 9.49e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 48.22  E-value: 9.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLL--LIASVdvhtkteyhNYAIDWQTGA-GCDAAGF 447
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFpfVMASV---------RHGSGWIYGAlSCKVIAF 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY 511
Cdd:cd15005  80 LAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTY 143
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
365-628 1.14e-05

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 47.56  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTkteyHNYAIDWQTgagCDA 444
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLS----QRKAISYEA---CIA 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFavaLFPIFGISSYMKVSICLPMDIDS 524
Cdd:cd15938  76 QLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGF---LHSIVQTLLTIQLPFCGPNQVNN 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 ------PLSQL-----YVMSLL------VLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFtdflcMAP 587
Cdd:cd15938 153 ffcdvpPVIKLactdtCVTELLmvsnsgLISTVCFVVLVTSYTTILVTIRSTEGRRKALSTCASHLMVVTLF-----FGP 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   588 ISFFAISaslkvPLITVSKSKILLVLFYPINSCANPFLYAI 628
Cdd:cd15938 228 CIFIYAR-----PFSTFPVDKHVSVLYNVITPMLNPLIYTL 263
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
368-637 1.25e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 47.31  E-value: 1.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHtkteyhnYAIDWQTGAG-CDAAG 446
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTEL-------FGGVWPLPLVlCLLWV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL-FPIFGISSYMKVSI---CLPMDI 522
Cdd:cd15052  79 TLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSpIPVLGIIDTTNVLNngtCVLFNP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYVMSLLVLNVLafvVICGCYThiyltvrnpnITSSSSDTKIAKRMAMLIFTDFLCMAPisFFAI--------S 594
Cdd:cd15052 159 NFVIYGSIVAFFIPLLIM---VVTYALT----------IRLLSNEQKASKVLGIVFAVFVICWCP--FFITniltglceE 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 544349   595 ASLKVPLITVSkskILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15052 224 CNCRISPWLLS---VFVWLGY-VSSTINPIIYTIFNKTFRRAF 262
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
374-627 1.67e-05

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 47.09  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVL-VILITSQyKLTVPRFLMCNLAFADLCIgiylLLIASVDVHTKTEYHnyaidWQTG-AGCDAAGFFTVF 451
Cdd:cd14975  12 AIGLPGNSFVIwSILIKVK-QRSVTMLLVLNLALADLAV----LLTLPVWIYFLATGT-----WDFGlAACKGCVYVCAV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWI--FAFAVALFPIFGISSYMKVSICLPMDidsPLSQL 529
Cdd:cd14975  82 SMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLlaVLLATPVIAFRHVEETVENGMCKYRH---YSDGQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   530 YVMSLLVLNVLAFVV----ICGCYTHIYltvRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAI----SASLKVPL 601
Cdd:cd14975 159 LVFHLLLETVVGFAVpftaVVLCYSCLL---RRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLlevvSELIGGSK 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 544349   602 ITVSKSKILLVLFYP------INSCANPFLYA 627
Cdd:cd14975 236 MAGTLGKVAEAGRPIagalafLSSSINPLLYA 267
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
456-637 1.82e-05

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 47.11  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   456 SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPIFGISSYMKV---SICLPMDIDSPLSQLYVM 532
Cdd:cd15338  90 STYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSL-LSITPVWMYAGLMPLpdgSVGCALLLPNPETDTYWF 168
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   533 SL---LVLNVLAFVVICGCYTHIYL----TVRNPNITSSSSDTKIAKRMAMLI-FTDFLCMAPISFFAISA-SLKVPLIT 603
Cdd:cd15338 169 TLyqfFLAFALPLVVICVVYFKILQnmasTVAPLPQRSLRVRTKKVTRMAVAIcLAFFICWAPFYILQLAHlSIDRPSLA 248
                       170       180       190
                ....*....|....*....|....*....|....
gi 544349   604 VSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15338 249 FLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
364-637 1.95e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 46.69  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLvILITSQYKLTVPRFL-MCNLAFADLCIGIYLLliASVDVHTKTEYHNYAIDWQTGAGc 442
Cdd:cd15102   2 ATSVVFVAICCFIVLENLLVL-IAIWRHMKFHRPMYYfLGNLALSDLLAGAAYL--ANILLSGARTLRLSPAQWFLREG- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 daaGFFTVFASelSVYTLTAITLERWHTIT----HAMQLECKVQLRHAASimlvgWIFAFAVALFPIFG---ISSYMKVS 515
Cdd:cd15102  78 ---SMFVALSA--SVFSLLAIAIERHLTMAkmkpYGASKTSRVLLLIGAC-----WLISLLLGGLPILGwncLGALDACS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMdidspLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVR-----NPNITSSSSDTKIAKRMAMLIFTDFLCMAPIsF 590
Cdd:cd15102 148 TVLPL-----YSKHYVLFCVTIFAGILAAIVALYARIYCLVRasgrkATRASASPRSLALLKTVLIVLLVFIACWGPL-F 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   591 FAISASLKVPLIT---VSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15102 222 ILLLLDVACPVKTcpiLYKADWFLALAV-LNSALNPIIYTLRSRELRRAV 270
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
367-637 2.01e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 46.74  E-value: 2.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGiyLLLIASVDVHTKTEYhnyaidWQTGAG-CDAA 445
Cdd:cd15301   5 IVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIG--VISMPLFTVYTALGY------WPLGYEvCDTW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfaVALFPIFGIS-SYMKVSICLPMD--- 521
Cdd:cd15301  77 LAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIIS--LLLWPPWIYSwPYIEGKRTVPAGtcy 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVM--SLLVLNVLAFVVICGCYTHIYltvRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKV 599
Cdd:cd15301 155 IQFLETNPYVTfgTALAAFYVPVTIMCILYWRIW---RETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFP 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   600 PLITVSKskILLVLFYP---INSCANPFLYAIFTKNFRRDF 637
Cdd:cd15301 232 CSDTIPT--ELWDFSYYlcyINSTINPLCYALCNAAFRRTY 270
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
372-637 2.42e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 46.76  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIA-SVDVHTKTEYHNyaidwqtgagCDAAGFFTV 450
Cdd:cd15071  10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAiIINIGPQTEFYS----------CLMVACPVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKV-----------SICLP 519
Cdd:cd15071  80 ILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVerawaanssmgELVIK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   520 MDIDSPLSQLYVMSL----LVLNVLAFVVIcgCYTHIYLTVR---NPNITSSSSDT--------KIAKRMAMLIFTDFLC 584
Cdd:cd15071 160 CQFETVISMEYMVYFnffvWVLPPLLLMLL--IYLEVFYLIRkqlNKKVSSSSSDPqkyygkelKIAKSLALILFLFALS 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   585 MAP------ISFFAisASLKVPLITVskskILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15071 238 WLPlhilncITLFC--PSCKKPMILT----YIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
367-511 3.10e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 46.09  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIyLLLIASVDVHTKTEYHnYAIDWqtgagCDAAG 446
Cdd:cd15214   4 IAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSV-LVLPFVVTSSIRREWI-FGVVW-----CNFSA 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSY 511
Cdd:cd15214  77 LLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSL 141
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
372-637 3.36e-05

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 46.10  E-value: 3.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlCIGIYLLLIASVDVHTKTeyhnyaidWQTGAG-CDAAGFFTV 450
Cdd:cd15089  10 VCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMET--------WPFGELlCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQ-LECKVQLRhAASIMLVGWIFAFAVAlFPIFGISSYMK----VSICLPMDIDSP 525
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKaLDFRTPAK-AKLINICIWVLSSGVG-VPIMVMAVTKTprdgAVVCMLQFPSPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYVMSLLVLnVLAFV----VICGCYTHIYLTVRNPNITSSSSDT----KIAKRMAMLIFTDFL-CMAPISFFAISAS 596
Cdd:cd15089 159 WYWDTVTKICVF-IFAFVvpilVITVCYGLMILRLRSVRLLSGSKEKdrnlRRITRMVLVVVAAFIiCWTPIHIFVIVWT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 544349   597 L----KVPLITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15089 238 LvdidRRNPLVVAALHLCIALGY-ANSSLNPVLYAFLDENFKRCF 281
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
367-637 3.53e-05

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 45.80  E-value: 3.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIyLLLIASVDVHTKTEYHNYAIDwqtgagCDAAG 446
Cdd:cd15309   5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVAT-LVMPWVVYLEVVGEWRFSRIH------CDIFV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIML-VGWIFAFAVALFPIFGISSyMKVSICLpmdIDSP 525
Cdd:cd15309  78 TLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIsVVWVLSFAISCPLLFGLNN-TDQNECI---IANP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYvmSLLVLNVLAFVVICGCYTHIYLTVRNpnitssssDTKIAKRMAMLIFTDFLCMAP---ISFFAISASLKVPLI 602
Cdd:cd15309 154 AFVVY--SSIVSFYVPFIVTLLVYVQIYIVLQK--------EKKATQMLAIVLGVFIICWLPffiTHILNMHCDCNIPPA 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 544349   603 TVSKSKILLVlfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15309 224 LYSAFTWLGY----VNSAVNPIIYTTFNIEFRKAF 254
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
364-634 4.07e-05

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 45.89  E-value: 4.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFIS-ILAITGNilVLVILITS-QYKLTVPRFLMCNLAFADLcigIYLLLIASVDVHTKTEYHnyaidWQTG-A 440
Cdd:cd15119   1 IVSIVIYIVAfVLGVPGN--AIVIWVTGfKWKKTVNTLWFLNLAIADF---VFVLFLPLHITYVALDFH-----WPFGvW 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 GCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAV---ALFPIFGISSYMKVSIC 517
Cdd:cd15119  71 LCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAIsgpALYFRDTMELSINVTIC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LP--MDIDSPLSQLYVMSLLVLN-----VLAFVVICGCYTHIYLTVRNPNITSSSsdtKIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd15119 151 FNnfHKHDGDLIVMRHTILVWVRfffgfLFPLLTMVVCYSLLAIKVKRRTLLISS---KFFWTISAVIVAFFVCWTPYHI 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   591 FAIsasLKVPLITVSKSKILLVLFYP-------INSCANPFLYAIFTKNFR 634
Cdd:cd15119 228 FSI---LELSIHHSSYLHNVLRAGIPlatslafINSCLNPILYVLIGKKFK 275
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
364-635 4.20e-05

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 45.93  E-value: 4.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILItsqYKLTVPRFLMC---NLAFADLCIGIYLLLiaSVDVHTKTEYHNYAIDWQTGA 440
Cdd:cd15349   2 ALTVLFICISVLIILENLLVLLAIL---RRVRLRRWVYIclaNIALSDLLTGTSYLV--NICLSGERTFRLTPALWFLRE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 GCdaagFFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIC--- 517
Cdd:cd15349  77 GL----LFTALAA--STFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSCssl 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 LPMdidspLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRN-----PNITSSSSDTKIAKRMAMLIFTDFLCMAP----- 587
Cdd:cd15349 151 LPL-----YSKSYILFCLVIFFIILLTIIGLYFAIYCLVRAsgqrvISARSRRRSLRLLKTVLMILGAFMVCWGPlfill 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   588 -ISFFAISASLKvPLITVSKSKILLVLfypiNSCANPFLYAIFTKNFRR 635
Cdd:cd15349 226 lVDFFCSSRSCK-PLFGMEWVLALAVL----NSAINPLIYSFRSLEVRR 269
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
372-637 4.30e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 45.78  E-value: 4.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYllliaSVDVHTKTEYHNYaidWQTGA-GCDAAGFFTV 450
Cdd:cd15298  10 LSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAF-----SMNLYTVYIIKGY---WPLGAvVCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAF-----AVALFPIFGISSYMKVSICLPMDIDSP 525
Cdd:cd15298  82 VVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFvlwapAILFWQFVVGKRTVPDNQCFIQFLSNP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 lsQLYVMSLLVLNVLAFVVICGCYTHIYLtvrnpnitSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVS 605
Cdd:cd15298 162 --AVTFGTAIAAFYLPVVIMTVLYIHISL--------ASARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDT 231
                       250       260       270
                ....*....|....*....|....*....|..
gi 544349   606 KSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15298 232 VWSIGYWLCY-VNSTINPACYALCNATFKKTF 262
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
372-637 4.38e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 46.05  E-value: 4.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAIT-GNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaiDWQTGA-GCDAAGFFT 449
Cdd:cd15959   9 LAILVIVgGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTG--------HWPLGTtVCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF-----------GISSYMKVSIC- 517
Cdd:cd15959  81 VLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMnqwwrdgadeeAQRCYDNPRCCd 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   518 ----LPMDIDSPLSQLYVMSLLVLNVLAFVVICGCyTHIYL----TVRNPNITSSSSDTKIAKR---------------- 573
Cdd:cd15959 161 fvtnMPYAIVSSTVSFYVPLLVMIFVYVRVFVVAT-RQVRLirkdKVRFPPEESPPAESRPACGrrpsrllaikehkalk 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   574 ---MAMLIFTdfLCMAPISFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAiFTKNFRRDF 637
Cdd:cd15959 240 tlgIIMGTFT--LCWLPFFVANIIKVFCRSLVPDPAFLFLNWLGY-ANSAFNPIIYC-RSPDFRSAF 302
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
371-634 4.39e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 45.97  E-value: 4.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITG-NILVLVILITSQYKLTVPR--FLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYAIDWQTGagCDAAGF 447
Cdd:cd15077   6 FMLFLVIAGfPINVLTIICTIKYKKLRSHlnYILVNLAVANL-----IVVCFGSTTAFYSFSQMYFVLGPLA--CKIEGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   448 FTVFASELSVYTLTAITLERWHTITHAMQlECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSI---CLP---MD 521
Cdd:cd15077  79 TATLGGMVSLWSLAVVAFERFLVICKPLG-NFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLqcsCGPdwyTT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLSQLYVMSLLVLNV-LAFVVICGCYTHIYLTVR------NPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAI- 593
Cdd:cd15077 158 NNKWNNESYVMFLFCFCFgVPLSIIVFSYGRLLLTLRavakqqEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALw 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   594 -----SASLKVPLITVSKskillvLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15077 238 vvtnrGEPFDLRLASIPS------VFSKASTVYNPVIYVFMNKQFR 277
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
374-636 4.64e-05

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 45.89  E-value: 4.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvHTKTEYhnyaidWQTG-AGCDAAGFFTVFA 452
Cdd:cd15397  12 AVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVV--YTLMDY------WIFGeVLCKMTPFIQCMS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAL----FPIFGISSYMKVSICLPMDIDS---- 524
Cdd:cd15397  84 VTVSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLpflaFHILTDEPYKNLSHFFAPLADKavct 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 ---PLSQL---YVMSLLVLNV---LAFVVICgcYTHIYLTVRNPN--ITSSSSDTKIAKRM----AML--IFTDF-LCMA 586
Cdd:cd15397 162 eswPSEHHklaYTTWLLLFQYclpLLFILVC--YLRIYLRLRRRKdmLERRGEYNRRAGHSkrinVMLvsLVAAFaLCWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 544349   587 PISFFAISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRD 636
Cdd:cd15397 240 PLNVFNAIADWNHEAIPHCQHNLIFSLCHLAamaSTCVNPIIYGFLNSNFKKE 292
LRRNT smart00013
Leucine rich repeat N-terminal domain;
17-50 4.74e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 4.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544349       17 GCHHRlCHCSNGVFLCQESKVTEIPSDLPRDAVE 50
Cdd:smart00013   1 ACPAP-CNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
371-634 4.80e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 45.59  E-value: 4.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcIGIYLLLIASVDVHTKteYHNYAIDwqtgagCDAAGFFTV 450
Cdd:cd14989   9 FLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADL-ILVADSLIEVFNLNEK--YYDIAVL------CTFMSLFLQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFP--IFGISSYMKVSICLpmdidSPLSQ 528
Cdd:cd14989  80 INMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPftAVQAQHTGEVHFCF-----ADVRE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMSLLVLNVLAFVVICGCYTHIYLT-VRNPNITSSSSDTKIAKRM-AMLIFTDFLCMAPISFFAISASLKVPLITVSK 606
Cdd:cd14989 155 IQWLEVTLGFIIPFSIIGLCYSLIVRVlVRAQKHRRLRPRRQKALRMiLVVVLVFFICWLPENVFISIQLLQGTQEPSES 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   607 SKILLVLFYPI-----------NSCANPFLYAIFTKNFR 634
Cdd:cd14989 235 YDESFRHNHPLtghivnlaafsNSCLNPLIYSFLGETFR 273
LRR_5 pfam13306
Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This ...
56-123 5.39e-05

Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 433104 [Multi-domain]  Cd Length: 127  Bit Score: 43.30  E-value: 5.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544349      56 TKLRVIPKGAFSGFGDLEKIEISQNdvLEVIEANVFSNLpKLHEIRIEkaNNLLYIDPDAFQNLPNLR 123
Cdd:pfam13306  65 SSLTSIGEYAFSNCSNLKSITLPSN--LTSIGSYAFSNC-SLKSITIP--SSVTTIGSYAFSNCSNLK 127
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
364-635 5.51e-05

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 45.51  E-value: 5.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhTKTEYHnyaiDWQTGAG-C 442
Cdd:cd15193   2 YIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAA----STALGG----QWLFGEGlC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSIClpmdI 522
Cdd:cd15193  74 KLSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGI-PSLVYRNLINESVC----V 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   523 DSPLSQLYV-MSLLVL---NVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAK--RMAMLIFTDFLC-------MAPIS 589
Cdd:cd15193 149 EDSSSRFFQgISLATLfltFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNslRIVFAIVTAFVLswlpfntLKAVR 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 544349   590 FFAISASLKVPLITVSKSKILLVL---FYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15193 229 LLLELGGGVLPCHTTVAIRQGLTItacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
367-637 5.95e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 45.31  E-value: 5.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHtkteyhnYAIDWQTGAG-CDAA 445
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTIL-------YGYRWPLPSKlCAVW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 GFFTVFASELSVYTLTAITLERWHTI---THAMQLECKVQLRhaASIMLVgWIFAFAVAL-FPIFGISSYMKV---SICL 518
Cdd:cd15304  78 IYLDVLFSTASIMHLCAISLDRYIAIrnpIHHSRFNSRTKAF--LKIIAV-WTISVGISMpIPVFGLQDDSKVfkeGSCL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLLVLNVLAFVVicgcythiYLTVRNPNiTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLK 598
Cdd:cd15304 155 LADENFVLIGSFVAFFIPLTIMVITY--------FLTIKSLQ-QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVIC 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 544349   599 VPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15304 226 KESCNEVVIGGLLNVFVWIgylSSAVNPLVYTLFNKTYRSAF 267
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
367-637 6.37e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 45.09  E-value: 6.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVlVILITSQYKLTVPRFLMCNLAFADL--CIGIYLLLIASVDVHtkteyhnyaiDWQTG-AGCD 443
Cdd:cd15114   5 VLYAVVFLVGVPGNALV-AWVTGFEAKRSVNAVWFLNLAVADLlcCLSLPILAVPIAQDG----------HWPFGaAACK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAL------------FPI------ 505
Cdd:cd15114  74 LLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVpsfiyrrihqehFPEktvcvv 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   506 -FGISSYMKVSIClpmdidsplsqlyVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSssdTKIAKRMAMLIFTDFLC 584
Cdd:cd15114 154 dYGGSTGVEWAVA-------------IIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKS---RRTLKVVTAVVVGFFLC 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   585 MAPIS----FFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15114 218 WTPYHvvglIIAASAPNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
17-45 7.44e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 7.44e-05
                          10        20
                  ....*....|....*....|....*....
gi 544349      17 GCHHRlCHCSNGVFLCQESKVTEIPSDLP 45
Cdd:pfam01462   1 ACPVP-CHCSATVVNCSDRGLTAVPRDLP 28
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
372-637 7.97e-05

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 45.02  E-value: 7.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLV-ILITSQYKLTVpRFLMCNLAFADLCIGI-YLLLIASVDVHTKteyHNYAIDWQTGAGCDAAGFFT 449
Cdd:cd15344  10 VCIFIMLANLLVMVaIYVNRRFHFPI-YYLMANLAAADFFAGLaYFYLMFNTGPNTR---RLTVSTWLLRQGLIDTSLTA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 vfaselSVYTLTAITLERwHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSICLPMdidSPL-SQ 528
Cdd:cd15344  86 ------SVANLLAIAIER-HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNM---APLySD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTK----------IAKRMAMLIFTDFLCMAPiSFFAISASLK 598
Cdd:cd15344 156 SYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGprrnrdtmmsLLKTVVIVLGAFIICWTP-GLVLLLLDVC 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 544349   599 VPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15344 235 CPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
378-635 8.47e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 44.96  E-value: 8.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   378 TGNILVLVILItsQYK--LTVPRFLMCNLAFADLcigiyllLIASVDVHTKTEYhnYAI---DWQTG-AGCDAAGFFTVF 451
Cdd:cd15204  16 VGNLLLIAVLA--RYKklRTLTNLLIANLALSDF-------LVAVFCLPFEMDY--YVVrqrSWTHGdVLCAVVNYLRTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHamQLECKVQLRHAASIMLVGWIFAFAVAL--------FPIFGISSymkvSIC---LPM 520
Cdd:cd15204  85 SLYVSTNALLVIAIDRYLVIVH--PLKPRMKRRTACVVIALVWVVSLLLAIpsavysktTPYANQGK----IFCgqiWPV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DiDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTV---RNPNITSSSSDTKIAKR-----MAMLIFTDF-LCMAPISF 590
Cdd:cd15204 159 D-QQAYYKAYYLFLFVLEfVLPVLIMTLCYLRIVRKVwfrRVPGQQTEQIRRRLRRRrrkvrLLVVILTAFvLCWAPYYG 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   591 FAISASLKVPLItvSKSKILLVLFYPI------NSCANPFLYAIFTKNFRR 635
Cdd:cd15204 238 YAIVRDFFPTLL--SKEKLNTTIFYIVealamsNSMINTVVYVAFNNNIRK 286
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
365-637 9.13e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 44.73  E-value: 9.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   365 LRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyhnYAIDWQTGAGCDA 444
Cdd:cd15050   3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIV----------YLLESKWILGRPV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVF---ASELSVYTLTAITLERWHTITHAMQLeCKVQLRHAASIMLVG-WIFAFaVALFPIFGISSYMKV--SICL 518
Cdd:cd15050  73 CLFWLSMdyvASTASIFSLFILCIDRYRSVQQPLKY-LKYRTKTRASLMISGaWLLSF-LWVIPILGWHHFARGgeRVVL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   519 PMDIDSPLSQLYVMSLL--VLNVLAFVVICGC-YTHIYLTVRNpnitssssDTKIAKRMAMLIFTDFLCMAP--ISFFAI 593
Cdd:cd15050 151 EDKCETDFHDVTWFKVLtaILNFYIPSLLMLWfYAKIFKAVNR--------ERKAAKQLGFIMAAFILCWIPyfILFMVI 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   594 SASLKVPLITVSKSKILLVLfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15050 223 AFCKNCCNENLHMFTIWLGY---INSTLNPFIYPLCNENFKKTF 263
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
351-639 1.13e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 44.77  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    351 DAFNPCEDIMGDD----ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMcNLAFADLcigiylLLIASVDVHTk 426
Cdd:PHA03087  25 EDYADCDLNIGYDtnstILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLL-NLAVSDL------LFVMTLPFQI- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    427 teYHNYAIDWQTGA-GCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFaVALFPI 505
Cdd:PHA03087  97 --YYYILFQWSFGEfACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISI-IETTPI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    506 FGISSYMKV---SICLPM-DIDSPLSQLYVMslLVLNVLAFVV----ICGCYTHIYLTVRNPNITSSSsdtKIAKRMAML 577
Cdd:PHA03087 174 LFVYTTKKDhetLICCMFyNNKTMNWKLFIN--FEINIIGMLIpltiLLYCYSKILITLKGINKSKKN---KKAIKLVLI 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544349    578 IFTDF-LCMAP--ISFFAISA-SLKVPLITVSKSKILLVLFYP-----INSCANPFLYAI----FTKNFRRDFFI 639
Cdd:PHA03087 249 IVILFvIFWLPfnVSVFVYSLhILHFKSGCKAVKYIQYALHVTeiislSHCCINPLIYAFvsefFNKHKKKSLKL 323
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
371-634 1.18e-04

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 44.32  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASvdvhtkteYHNYAIDWQTG-AGCDAAGFFT 449
Cdd:cd15157   9 IIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRAD--------YYLMGSHWVFGdIACRIMSYSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF-GISSYMKVSICLPMDIDSpLSQ 528
Cdd:cd15157  81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSkGTSKYNSQTKCLDLHPSK-IDK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMSLLVLNV---LAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTdfLCMAPISFFAISASLKVPLITVS 605
Cdd:cd15157 160 LLILNYIVLVVgfiLPFCTLSICYILIIKALLKPRVPQSKLRVSHKKALLTIIIT--LILFLLCFLPYHILRTVHLMQWS 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 544349   606 KSK---------ILLVLFYPINSCANPFLYAIFTKNFR 634
Cdd:cd15157 238 EGQcnlrlhkavVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
456-637 1.19e-04

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 44.32  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   456 SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGI---SSYMKVSICLPMDiDSPLSQLYVM 532
Cdd:cd15922  87 SIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGL-PFFFVlktSVIDGKTKCLSIH-QSELSLLYFV 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   533 SLLVLNVLAFVVICG----CYTHIYLTVRNPNITSSSSDTKIAKRMAM-----LIFTdfLCMAPIS-----------FFA 592
Cdd:cd15922 165 WNFVLLILGFLLPFGvsltCYALLGASIAKMNSNNARGRAMKAKSLQMigislVIFI--ICFVPLHvtrtvgvvvklFYP 242
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 544349   593 ISASLkvpLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15922 243 ESCTL---LHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
364-635 1.33e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 44.46  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVdvhtkteyHNYAIDWQTGAG-C 442
Cdd:cd15316   2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTV--------RSVESCWYFGESfC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVAlFPIFGISSY------MKVSI 516
Cdd:cd15316  74 TFHTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYS-FSVFYTGVNddgleeLVNAL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRN---------PNITSSSSDTK--IAKRMAMLIFTDFLCM 585
Cdd:cd15316 153 NCVGGCQIILNQNWVLVDFLLFFIPTFAMIILYGKIFLVAKQqarkiemtsSKAESSSESYKdrVARRERKAAKTLGITV 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 544349   586 APISFFAISASLKVpLITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRR 635
Cdd:cd15316 233 IAFLVSWLPYLIDV-LIDAFMNFITPPYIYEIccwcayyNSAMNPLIYALFYPWFRK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-240 1.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 44.57  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    72 LEKIEISQNDVLEVIEAnvFSNLPKLHEIRIekANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAVHKIQSLQKVLLD- 150
Cdd:COG4886 211 LEELDLSNNSIIELLSS--LSNLKNLSGLEL--SNNKLEDLPESIGNLSNLETLDLSNNQISSISSLGSLTNLRELDLSg 286
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   151 ----------IQDNINIHTVERNSFMGLSFE--SMTVWLSK----NGIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVF 214
Cdd:COG4886 287 nslsnalpliALLLLLLELLLNLLLTLKALElkLNSILLNNnilsNGETSSPEALSILESLNNLWTLDNALDESNLNRYI 366
                       170       180
                ....*....|....*....|....*.
gi 544349   215 QGAsgPVILDISRTRIRSLPSYGLEN 240
Cdd:COG4886 367 VKN--PNAIGSLLDLVKKHVNQLLEK 390
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
372-637 1.50e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 44.09  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIylLLIASVDVHTKTEYHNYAIDWqtgagCDAAGFFTVF 451
Cdd:cd15324  10 IILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVAT--LVIPFSLANEVMGYWYFGSTW-----CAFYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIfgISSYMKVSICLPMDidsplSQLYV 531
Cdd:cd15324  83 FCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPL--LMTKHDEWECLLND-----ETWYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   532 MSLLVLNVLA-FVVICGCYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSkiL 610
Cdd:cd15324 156 LSSCTVSFFApGLIMILVYCKIYRVAK-------MREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDA--L 226
                       250       260       270
                ....*....|....*....|....*....|
gi 544349   611 LVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15324 227 FNLFFWIgycNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
364-635 1.63e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.99  E-value: 1.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLV-ILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaidwQTGAG- 441
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLcFLYSAELRKQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRN----------RQPFGd 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   442 --CDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWI----FAFAVALFPIFGISS-YMKV 514
Cdd:cd15219  71 gfCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLhsltFSLVALFLSWLGYSSlYASC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   515 SICLPMDIDSPLSQLYVMSL-LVLNVLAFVVICGCYTHiYLTVRNPNitssssdtKIAKRMAMLIFTDFLCMAPIsffai 593
Cdd:cd15219 151 TLHLPREEERRRFAVFTAFFhAFTFLLSLLVLCVTYLK-VLKVRRRQ--------RATKKISIFIGTFVLCFAPY----- 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   594 saslkvplitVSKSKILLVLFYPINS--------------CANPFLYAIFTKNFRR 635
Cdd:cd15219 217 ----------VITRLVELLPFVTINRywgivskcltyskaASDPFVYSLLRQQYRK 262
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
372-636 2.07e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 43.99  E-value: 2.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTkteyhnyaiDWQTG--AGCDAAGFFT 449
Cdd:cd15388  10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDIT---------DRFRGpdVLCRLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASImLVGWIFAFAVALFPIFgISSYMKVSI----CLPMDIDSP 525
Cdd:cd15388  81 VVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPV-CVAWAISLILSLPQVF-IFSKVEVAPgvyeCWACFIEPW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   526 LSQLYV--MSLLVLnVLAFVVICGC--------YTHIYL------TVRNPNITSSSSDTKIAK---------RMAMLIFT 580
Cdd:cd15388 159 GLKAYVtwITLVVF-VLPTLIITVCqvlifkeiHINIYLksqiivAVVKKKQLLSSRASSVAEvskamiktvKMTLVIVL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   581 DF-LCMAPisFFAIS--ASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15388 238 VYvLCWAP--FFLVQlwSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAFSSSVSKE 294
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
368-635 2.38e-04

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 43.49  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILaitGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLlliasvdvHTKTEYHNYAIDWQTGAG-CDAAG 446
Cdd:cd15159   9 LILVFGLL---GNTLALHVICQKRKKINSTTLYLINLAVSDILFTLAL--------PGRIAYYALGFDWPFGDWlCRLTA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF-GISSYMKVSI-CLPMDIDS 524
Cdd:cd15159  78 LLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFmPMTKEMGGRItCMEYPNFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYVMsLLVLNVLAFVV----ICGCYTHI----YLTVRNPNITSSSSDTKIAKRMAMLIFTDFL-CMAP----ISFF 591
Cdd:cd15159 158 KIKRLPLI-LLGACVIGFGVpvgiILFCYSQItlklCRTAKENPLTEKSGHHKKACNVILLVLLVFVvCFSPyhlnIIQF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   592 AISASLKVPLITVSKS-KILL---VLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15159 237 MIRKLLYQPSCSELKAfKISLqitVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
374-637 2.52e-04

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 43.58  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCigiyLLLIASVDVhtkTEYhnyAIDWQTGA-GCDAAGFFTVFA 452
Cdd:cd15181  12 LLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLL----LLLTFPFSV---VES---IAGWVFGTfLCKLVGAIHKLN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   453 SELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGI----SSYMKVSICLPMDIDSPLSQ 528
Cdd:cd15181  82 FYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLevetSTNANRTSCSFHQYGIHESN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMSLLVLNVLAF----VVICGCYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDF-LCMAPISFFAISASLKVPLIT 603
Cdd:cd15181 162 WWLTSRFLYHVVGFflplLIMGYCYATIVVTLCQ---SSRRLQKQKAIRVAILVTLVFcLCWLPYNIVIFLDTLDDLKAV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 544349   604 VSKSKILLVLFYPI---------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15181 239 VKNCKLNDLLDAAItvteslgfsHCCLNPILYAFIGVKFRNDL 281
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
375-635 2.89e-04

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 43.32  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   375 LAITGNILVLVILITSQYKLTVP--RFLMCnLAFADLCIGIYLLLIAsvdVHTKTEYHnyaidWQTG-AGCDAAGFFTVF 451
Cdd:cd15925  13 IGLLGNLAVMYLLRNCARRAPPPidVFVFN-LALADFGFALTLPFWA---VESALDFH-----WPFGgAMCKMVLTATVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAfAVALFP--IFGISS-YMKVSICL-PMDIDSPLS 527
Cdd:cd15925  84 NVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAA-LLATVPtaIFATEGeVCGVELCLlKFPSNYWLG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   528 QLYVMSLLVLNVLAFVVICGCYTHI--YLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAP---ISFFAISasLKVPLI 602
Cdd:cd15925 163 AYHLQRVVVAFVVPLGVITTSYLLLlsFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPnhvVTFWGVL--VKFRAV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 544349   603 TVSKSKILLVLF-YPI-------NSCANPFLYAIFTKNFRR 635
Cdd:cd15925 241 PWNSTFYFIHTYvFPVttclahsNSCLNPVLYCLMRREFRQ 281
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
383-637 2.94e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 43.09  E-value: 2.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   383 VLVILITSQYKLTVPRFLMC-NLAFADLCIGIYLLLiasvdvhtkteYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLT 461
Cdd:cd15961  20 IVVLIIFQNPSLRAPMFLLIgSLALADLLAGIGLIL-----------NFIFAYLLQSEAAKLVTVGLIVASFSASVCSLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   462 AITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIClpmDIDSPLSQLYVMSLLVLNVLA 541
Cdd:cd15961  89 AITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADESTC---SVVRPLTKNNAAILSVSFLLM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   542 FVVICGCYTHI---------YLTVRNPNITSSSSDT--KIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSkiL 610
Cdd:cd15961 166 FALMLQLYIQIckivmrhahQIALQHHFLATSHYVTtrKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYAT--L 243
                       250       260
                ....*....|....*....|....*..
gi 544349   611 LVLFYpiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15961 244 LPATY--NSIINPVIYAFRNQEIQKAL 268
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
372-590 3.06e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 43.23  E-value: 3.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGcDAAGFFTVF 451
Cdd:cd15350  10 IAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGPFETKLD-DIMDSLFCL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   452 ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFpIFGISSYMKVSIClpmdidsplsqlyv 531
Cdd:cd15350  89 SLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGIL-MILFFHFVATVIC-------------- 153
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   532 msLLVLNVLAFVVICGCYTHIYLTVR----------NPNITSSSSDTKIAKRMAMLIFTDFLCMAPISF 590
Cdd:cd15350 154 --FTVLFFLMLVLILCLYVHMFLLARsharkiaslpNHHAQHQRSNMRGAITLTILLGVFVCCWAPFVL 220
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
369-629 4.06e-04

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 42.88  E-value: 4.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   369 IWFISILAITG---NILVLVILITSQYKL---TVPRFL--MCNLAFADLcigIYLLLIASVDVhtktEYHNYAIDWQT-G 439
Cdd:cd15143   4 VWFSTIFSAIGlasNLFAFIVLVKSSRKTksrSRSSFLifLCGLVVTDF---LGLLVTGTIVI----SFHLTNFNWRVvD 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   440 AGCDAAGFF---TVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYM---- 512
Cdd:cd15143  77 PDCYLCNFMglsMVFYGLCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLGRYTlqyp 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   513 -------------KVSICLpmdIDSPLSQLYVMSLLVLNVLAFVVICGCYtHIYLTVRNPNitssSSDTKIAKRMAMLIF 579
Cdd:cd15143 157 gswcfltllfdskDVAFGL---LFSFLGILSVGLSFLLNTVSVVTLCRVY-HDRESVQRRR----DSEVEMMVQLLGIMV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   580 TDFLCMAPISFFAISASLKVPL-------ITVSKSKILLVL--FYPINSCANPFLYAIF 629
Cdd:cd15143 229 IASVCWLPLLVFIAQTVLQKPPamllagqIPRLTEKKLLIYlrFATWNQILDPWVYILF 287
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
367-637 4.79e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 42.56  E-value: 4.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIylLLIASVDVHTKTEYHNYAIDWQTGAGcdaaG 446
Cdd:cd15346   5 VVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV--AYTANLLLSGATTYKLTPTQWFLREG----S 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASelSVYTLTAITLERWHTIthaMQLECKVQLRHAASIMLVG--WIFAFAVALFPIFG---ISSYMKVSICLPMD 521
Cdd:cd15346  79 MFVALSA--SVFSLLAIAIERYITM---LKMKLHNGSNSFRSFLLISacWVISLILGGLPIMGwncISALSSCSTVLPLY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 IDSPLsqLYVMSLLVLNVLAFVVIcgcYTHIYLTVRNPNI----------TSSSSDTKIA--KRMAMLIFTDFLCMAPI- 588
Cdd:cd15346 154 HKHYI--LFCTTVFTLLLLSIVIL---YCRIYSLVRTRSRrltfrknirkASRSSEKSMAllKTVIIVLSVFIACWAPLf 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 544349   589 SFFAISASLKVPLITV-SKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15346 229 ILLLLDVGCKVKTCSIlFKAEYFLVLAV-LNSATNPIIYTLTNKEMRRAF 277
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
371-627 5.49e-04

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 42.56  E-value: 5.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQyKLTVP-RFLMCNLAFADLCIGI-YLLLIASVDVHTKTEYHNyaiDWQTGAGCDAAGFf 448
Cdd:cd15343   9 FCCLFIFVSNSLVIAAVVKNK-RFHYPfYYLLANLAAADFFAGIaYVFLMFNTGPVSKTLTVN---RWFLRQGLLDTSL- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   449 tvfasELSVYTLTAITLERWHTITHaMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIClpmdidSPLSQ 528
Cdd:cd15343  84 -----SASLTNLLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISAC------SSLAP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   529 LYVMSLL----VLNVLAFVVICGCYTHIYLTV-RNPNITSSSSDTKIAKR--------MAMLIFTDF-LCMAPISFFAIS 594
Cdd:cd15343 152 IYSRSYLvfwsVSNLVVFLIMVVVYLRIYVYVqRKTNVLSPHTSGSINRRrtpiklmkTVMTVLGAFvICWTPGLVVLLL 231
                       250       260       270
                ....*....|....*....|....*....|...
gi 544349   595 ASLKVPLITVSKSKILLVLFYPINSCANPFLYA 627
Cdd:cd15343 232 DGLNCTRCGVQHVKRWFLLLALLNSVMNPIIYS 264
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
456-637 5.58e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 42.42  E-value: 5.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   456 SVYTLTAITLERWHTITHAMQLECKV--QLRHAASIMLVGWIFAFAVAL-FPIFG--ISSYMKVSICLpMDIDSPLSQLY 530
Cdd:cd15087  86 SIYFLTVMSVDRYLVVLATVRSRRMPyrTYRAAKIVSLCVWLLVTIIVLpFTVFAgvYSNELGRKSCV-LSFPSPESLWF 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   531 VMSLLVLNVLAFVV----ICGCYTHIYLTVRNPNITSSSSDTKIAKR-MAMLIF----TDFLCMAPI---SFFAISASLK 598
Cdd:cd15087 165 KASRIYTLVLGFAIpvstICILYTMMLYKLRNMRLNSNAKALDKAKKkVTLMVLvvlaVCLFCWTPFhlsTVVALTTDLP 244
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 544349   599 VPLITVSKSKILLVLFYPiNSCANPFLYAIFTKNFRRDF 637
Cdd:cd15087 245 QTPLVIGISYFITSLSYA-NSCLNPFLYAFLDDSFRKSF 282
LRR_5 pfam13306
Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This ...
57-194 5.99e-04

Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 433104 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349      57 KLRVIPKGAFSGFGDLEKIEISQNdvLEVIEANVFSNLpKLHEIRIEkaNNLLYIDPDAFQNLPNLRYLLISNtgikhlp 136
Cdd:pfam13306  21 SLTSIGEYAFSNCTSLKSITLPSS--LTSIGSYAFYNC-SLTSITIP--SSLTSIGEYAFSNCSNLKSITLPS------- 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349     137 avhkiqslqkvlldiqdniNIHTVERNSFMGLSFESMTVWlskNGIQEIHNCAFNGTQ 194
Cdd:pfam13306  89 -------------------NLTSIGSYAFSNCSLKSITIP---SSVTTIGSYAFSNCS 124
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
371-635 6.11e-04

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 42.40  E-value: 6.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiylLLIASVDVHTKTEYHNyaiDWQTGAGCDAAGFFTV 450
Cdd:cd15152   9 VILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADL------LQVLSLPLRIFYYLNK---SWPFGKFLCMFCFYLK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASEL-SVYTLTAITLERWHTITHAMQLeCKVQLRHAASIMLVGWI-FAFAVALFPIFGISSYMKVSIC---LPM-DIDS 524
Cdd:cd15152  80 YVNMYaSIYFLVCISVRRCLYLIYPFRY-NDCKRKCDVYISIAGWLvVCVGCLPFPLLRQSQDTNPTCCfadLPLrNVGL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLYV-MSLLVLNVLAFVVICGCYTHIYLTVRNPN-ITSSSSDTKIAKRMAMLIFTDFL-CMAPISF-FAISASLKVP 600
Cdd:cd15152 159 TTSVIMLtIAELTGFVTPLLIVLYCSWKTVMSLREKTpVLQDLGEKKKALKMILTCAVVFLiCFAPYHIsFPLDFLVKSN 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 544349   601 LITVSKSKILLVLFYPI-------NSCANPFLYAIFTKNFRR 635
Cdd:cd15152 239 KIKSCTARKVILIFHPValclaslNSCLDPVIYYFTTDEFKR 280
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
364-637 8.45e-04

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 41.71  E-value: 8.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFI-SILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlciGIYLLLIASVDVHTKTEYhnyaidWQTGA-- 440
Cdd:cd15972   1 VLIPLVYLVvCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD---ELFMLGLPFLAAQNALSY------WPFGSfm 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   441 -----GCDAAGFFTvfaselSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVS 515
Cdd:cd15972  72 crlvmTVDAINQFT------SIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVL-PVVIFSGVPGGM 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   516 ICLPMDIDSPLSQLYVMSLLVLNVLAF----VVICGCYTHIYLTVRNPNITSSSSDTKIAK------RMAMLIFTDF-LC 584
Cdd:cd15972 145 GTCHIAWPEPAQVWRAGFIIYTATLGFfcplLVICLCYLLIVVKVRSSGRRVRATSTKRRGserkvtRMVVIVVAAFvLC 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   585 MAPisFFAIS-ASLKVPLitvSKSKILLVLFYPI------NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15972 225 WLP--FYALNiVNLVCPL---PEEPSLFGLYFFVvvlsyaNSCANPIIYGFLSDNFKQGF 279
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
370-556 1.07e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 41.46  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   370 WFIsILAITGNIL-----VLVILITSQYKLTVPRF-LMCNLAFADLCIGIYLLLiasvdvhtkTEYHNYAIDWQTGAGCD 443
Cdd:cd15962   3 WDI-MLCISGTVIacenaIVVAIIFYTPTLRTPMFvLIGSLATADLLAGCGLIL---------NFVFQYVIQSETISLIT 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAGFFTVFASelSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIClpmDID 523
Cdd:cd15962  73 VGFLVASFTA--SVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEERASC---SIV 147
                       170       180       190
                ....*....|....*....|....*....|...
gi 544349   524 SPLSQlyvmSLLVLNVLAFVVICGCYTHIYLTV 556
Cdd:cd15962 148 RPLTK----SNVTLLSASFFFIFILMLHLYIKI 176
LRR_8 pfam13855
Leucine rich repeat;
95-154 1.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544349      95 PKLHEIRIEkANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAV--HKIQSLQKvlLDIQDN 154
Cdd:pfam13855   1 PNLRSLDLS-NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRY--LDLSGN 59
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
372-637 1.99e-03

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 40.59  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIylLLIASVDVHTKTEYhnyaidWQTG-AGCDAAGFFTV 450
Cdd:cd15396  10 VTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCV--MCIPFTAVYTLMDH------WIFGeTMCKLTSFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQLecKVQLRHAASIMLVGWIFAFAVAL-FPIF---------GISS----YMKVSI 516
Cdd:cd15396  82 VSVSVSIFSLVLIAIERYQLIVNPRGW--KPSASHAYWGIVLIWLFSLMISIpFLIFhqltdepfrNLSShsdfYKDKVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLPMDIDSPLSQLYVMSLLVLNV---LAFVVICGCYTHIYLTVRNPNI------TSSSSDTKIAKRMAMLIFTDF-LCMA 586
Cdd:cd15396 160 CIEAWPSETERLIFTTSLLVFQYfvpLGFIFICYLKIFVCLKKRNSKIdrmrenESRLSENKRINTMLISIVVTFaACWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 544349   587 PISFFAISASLKVPLITVSKSKILLVLFY---PINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15396 240 PLNIFNVVFDWNHEVLMSCHHNLVFTLCHlvaMVSTCINPIFYGFLNKNFQKDL 293
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
368-637 2.19e-03

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 40.52  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILAITG---NILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIAsvdvhtkteyHNYAIDWQTGA-GCD 443
Cdd:cd15173   3 LPCMYSVMFVTGlvgNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWA----------YSAAHEWIFGTvMCK 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AA-GFFTV-FASelSVYTLTAITLERWHTITHAMQL---ECKVQLRHAASIMLVgWIFAFAVALfP--IFGISSYMKVSI 516
Cdd:cd15173  73 ITnGLYTInLYS--SMLILTCITVDRFIVIVQATKAhncHAKKMRWGKVVCTLV-WVISLLLSL-PqfIYSEVRNLSSKI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   517 CLpMDIDSPLSQLYV----MSLLVLNVLAFVVICgcYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFA 592
Cdd:cd15173 149 CS-MVYPPDAIEVVVniiqMTVGFFLPLLAMIIC--YSVIIKTLLH---AKGFQKHKSLKIIFVVVAVFILTQLPYNIMK 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 544349   593 ISASLKVPLITVSKSKILLVLFYPI---NSCANPFLYAIFTKNFRRDF 637
Cdd:cd15173 223 LIRTLHIENTDSTNFKYAILITEAIaylHACLNPILYAFVGVKFRKNF 270
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
372-637 2.23e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 40.66  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAIT-------GNILVLVILITSQYKLTVPRF-LMCNLAFADLcIGIYLLLIASVDVHTKTEYHNYAIDWQTGAGCD 443
Cdd:cd15340   3 IAVLSLTlgtftvlENLLVLCVILHSRSLRCRPSYhFIGSLAVADL-LGSVIFVYSFLDFHVFHRKDSPNVFLFKLGGVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   444 AAgfftvFASELSVYTLTAItlERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGISSYMKVSIClpMDID 523
Cdd:cd15340  82 AS-----FTASVGSLFLTAI--DRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNSVC--SDIF 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLL-VLNVLAFVVIcgcYTHIYLTVRNPN--------------ITSSSSDTKI--------------AKRM 574
Cdd:cd15340 153 PLIDETYLMFWIgVTSVLLLFIV---YAYMYILWKAHHhavrmlqrgtqksiIVYTSEDGKVqttrpdqtrmdirlAKTL 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544349   575 AMLIFTDFLCMAP---ISFFAISASLKVPLITVSKSKILLVLfypINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15340 230 VLILVVLIICWGPllaIMVYDVFGKMNKLIKTVFAFCSMLCL---LNSTVNPIIYALRSKDLRHAF 292
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
364-637 2.64e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 40.20  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAIT-GNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVHTKTEYHNYAIDWQTGAgC 442
Cdd:cd15308   1 AAALVGGVLLILAIIaGNVLVCLSVCTERALKTTTNYFIVSLAVADL-----LLALLVLPLYVYSEFQGGVWTLSPVL-C 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 DAAGFFTVFASELSVYTLTAITLERWhtITHAMQLECKVQLRHAASIMLVG--WIFAFAVALFPIFGISSYMkvsiclpm 520
Cdd:cd15308  75 DALMTMDVMLCTASIFNLCAISVDRF--IAVSVPLNYNRRQGSVRQLLLISatWILSFAVASPVIFGLNNVP-------- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   521 DIDSPLSQLYVMSLLVLN-VLAFVVICGCYTHIYLTVrnpnITSSSSDTKIAKRMAMLIFTDFLCMAPisFF------AI 593
Cdd:cd15308 145 NRDPAVCKLEDNNYVVYSsVCSFFIPCPVMLVLYCAM----FRGLGRERKAMRVLPVVVGAFLFCWTP--FFvvhitrAL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   594 SASLKVPLITVSkskILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15308 219 CESCSIPPQLIS---IVTWLGY-VNSALNPVIYTVFNAEFRNVF 258
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
113-258 3.09e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349     113 PDAFQNLPN-LRYLLISNTGIKHLPAVHKIQSLQKvlLDIQDNinihTVER-----NSFMGLsfESMTVWLSKNgIQEIH 186
Cdd:PLN03210  581 PEGFDYLPPkLRLLRWDKYPLRCMPSNFRPENLVK--LQMQGS----KLEKlwdgvHSLTGL--RNIDLRGSKN-LKEIP 651
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544349     187 NCAFnGTQLDELNLSDNSNLEELPNDVfQGASGPVILDISR-TRIRSLPS-YGLENLKKLRAKSTYRLKKLPSL 258
Cdd:PLN03210  652 DLSM-ATNLETLKLSDCSSLVELPSSI-QYLNKLEDLDMSRcENLEILPTgINLKSLYRLNLSGCSRLKSFPDI 723
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
368-635 3.46e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 39.82  E-value: 3.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   368 LIWFISILaitGNILVLVILITSQYKLTVPRFLMCNLAFADLcigiyLLLIASVDVhtkTEYHNYAIDWQTG-AGCDAAG 446
Cdd:cd15008   8 VLWLVSVF---GNSLVCLVIHRSRRTQSTTNYFVVSMACADL-----LLSVASAPF---VLLQFTSGRWTLGsAMCKLVR 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   447 FFTVFASELSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIF--AFAVALFPIFGISSYMKVSICLPmdiDS 524
Cdd:cd15008  77 YFQYLTPGVQIYVLLSICVDRFYTIVYP--LSFKVSREKAKKMIAASWLFdaAFVSPALFFYGSNWGPHCNFFLP---DS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLY-VMSLLVLNVLAFVVICGCYTHIY----------LTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPisFFAi 593
Cdd:cd15008 152 WDGAAYaIIHLLVGFLVPSILIILFYQKVIkyiwrigtdgRTVRRTMNIVPRTKVKTIKMFLMLNSMFLLSWLP--FYV- 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   594 sASLKVPLITVSKSKILLVLFYPI----NSCANPFLYAIFTKNFRR 635
Cdd:cd15008 229 -VQLWHPRESDYRQSSLVFLAVTWisfsSSASKPTLYSVYNANFRR 273
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
367-635 3.50e-03

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 39.82  E-value: 3.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAI--TGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHnyaidwqtgAGCDA 444
Cdd:cd15186   3 LSIFYSLVFAFglVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHN---------AMCKL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALfPIFgISSYMKVSICLPmDIDS 524
Cdd:cd15186  74 TTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAV-PQF-MFTKMKENECLG-DYPE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   525 PLSQLY-VMSLLVLNVLAFV----VICGCYTHIYLTVRNpniTSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKV 599
Cdd:cd15186 151 VLQEIWpVLRNVELNFLGFLlpllIMSYCYFRIIQTLFS---CKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKL 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 544349   600 ----PLITVSKS-KILLVLFYPI---NSCANPFLYAIFTKNFRR 635
Cdd:cd15186 228 ydffPSCDMKKDlRLALSVTETIafsHCCLNPLIYAFAGEKFRR 271
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
372-636 3.79e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.80  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASV-DVhtktEYHNYAIDWQtgagCDAAGFFTV 450
Cdd:cd15387  10 ILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIwDI----TFRFYGPDFL----CRLVKYLQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   451 FASELSVYTLTAITLERWHTITHAMQlecKVQLRHAASIMLVGWIFAFAVALfPIFGISSYMKVSI----CLPMDIDSPL 526
Cdd:cd15387  82 VGMFASTYMLLLMSIDRCLAICQPLR---SLHRRSDRVYVLFSWLLSLVFSI-PQVHIFSLREVGNgvydCWADFIQPWG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   527 SQLYVMSL-LVLNVLAFVVICGCYTHIYL---------TVRNPNITSSSSDTK------------IAK------RMAMLI 578
Cdd:cd15387 158 PKAYITWItLSVYIIPVLILSVCYGLISFkiwqnvklkTRRETKTPLSSAASGgaalarvssvklISKakirtvKMTFVI 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   579 FTDF-LCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRRD 636
Cdd:cd15387 238 VLAYiVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMFFTGHLFHD 296
LRR_8 pfam13855
Leucine rich repeat;
193-245 4.00e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 544349     193 TQLDELNLSDNsNLEELPNDVFQGASGPVILDISRTRIRSLPSYGLENLKKLR 245
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLR 52
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
371-506 4.25e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 39.75  E-value: 4.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   371 FISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADlcigIYLLLIASVDVHTKTEYHNyaidWQTG-AGCDAAGFFT 449
Cdd:cd15398   9 FISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSD----ILVVLFCSPFTLTCVLLDQ----WIFGeVMCHIVPFLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 544349   450 VFASELSVYTLTAITLERWHTITHAmqLECKVQLRHAASIMLVGWIFAFAV-ALFPIF 506
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHP--LSNHLTANHGYFLLGTVWTLGFTIcSPLPVF 136
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
372-637 4.34e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 39.51  E-value: 4.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   372 ISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIG-------IYLLLIASVDVHTKTEYHNyaIDwqtgagcda 444
Cdd:cd15353  10 LGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngsetVVITLLNGNDTDAQSFTVN--ID--------- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   445 AGFFTVFASEL--SVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIF-AFAVALFPIFGISSymKVSICLpmd 521
Cdd:cd15353  79 NVIDSVICSSLlaSICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTAcTVSGVLFIIYSDSS--VVIICL--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 idspLSQLYVMSLLVLNVlafvvicgcYTHIYLTVR----------NPNITSSSSDTKIAKRMAMLIFTDFLCMAPIsFF 591
Cdd:cd15353 154 ----ISMFFTMLALMASL---------YVHMFLLARlhikriavlpGTGPIRQGANMKGAITLTILLGVFVVCWAPF-FL 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 544349   592 AISASLKVP-----LITVSKSKILLVLFYpINSCANPFLYAIFTKNFRRDF 637
Cdd:cd15353 220 HLIFYISCPrnpycVCFMSHFNMYLILIM-CNSVIDPLIYAFRSQELRKTF 269
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
367-505 4.75e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 39.46  E-value: 4.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   367 VLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKT-EYHNYAIDWQTGAgcdaa 445
Cdd:cd15957   5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTwTFGNFWCEFWTSI----- 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   446 gffTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPI 505
Cdd:cd15957  80 ---DVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPI 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-245 5.55e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 39.57  E-value: 5.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349    93 NLPKLHEIRIEKaNNLLYIDPDAFQNLPNLRYLLISNTGIKHLPA--------------VHKIQSLQKVL--------LD 150
Cdd:COG4886 114 ELTNLTSLDLDN-NNITDIPPLIGLLKSNLKELDLSDNKIESLPSplrnlpnlknldlsFNDLSDLPKLLsnlsnlnnLD 192
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   151 IQDNiNIHTVErnSFMGLSFESMTVWLSKNGIQEIHNCAFNGTQLDELNLSdnSNLEELPNDVFQGASGPVILDISRTRI 230
Cdd:COG4886 193 LSGN-KISDLP--PEIELLSALEELDLSNNSIIELLSSLSNLKNLSGLELS--NNKLEDLPESIGNLSNLETLDLSNNQI 267
                       170
                ....*....|....*
gi 544349   231 RSLPSygLENLKKLR 245
Cdd:COG4886 268 SSISS--LGSLTNLR 280
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
399-511 7.64e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 38.88  E-value: 7.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   399 FLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaidWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQL 477
Cdd:cd15072  37 LLVLSLAVADMGISLNALVAASSSLLRR---------WPYGsEGCQAHGFQGFFTALASICSSAAIAWDRYHHYCTRSKL 107
                        90       100       110
                ....*....|....*....|....*....|....
gi 544349   478 ECKvqlrHAASIMLVGWIFAFAVALFPIFGISSY 511
Cdd:cd15072 108 QWS----TAISLVLFVWLFSAFWAAMPLLGWGEY 137
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
374-635 8.31e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 38.69  E-value: 8.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   374 ILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLL---LIASVDVHtkteyhnyaidWQTGAG-CDAAGFFT 449
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLpfsTIRSVESC-----------WYFGDSfCRLHTCLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   450 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIF------GISSYMKVSICLpmdid 523
Cdd:cd15318  81 TLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYtkaveeGLAELLTSVPCV----- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   524 SPLSQLYVMSLLVLNVLAFVVIC----GCYTHIYLTVRNPN--ITSSSSDT--------KIAKRMAMLIFTDFLCMAPIS 589
Cdd:cd15318 156 GSCQLLYNKLWGWLNFPVFFIPClimiGLYVKIFIVAKRQAraIASLLSDTngaskrerKAAKTLGIAVGVYLLCWLPFT 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 544349   590 FFAISASLkVPLITVSKSKILLVLFYPINSCANPFLYAIFTKNFRR 635
Cdd:cd15318 236 IDTMVDSL-LNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
364-565 8.35e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 38.62  E-value: 8.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQyKLTVPR-FLMCNLAFADLC---------IGIYLLLIASVDVhtkteyhnya 433
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDS-RLHTPMyFFLSNLSFLDICytsvtvpkmLANLLSGDKTISF---------- 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   434 idwqtgAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMqleckvqlrHAASIM---------LVGWIFAFAVALFP 504
Cdd:cd13954  71 ------SGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPL---------HYPTIMnkrvcillaAGSWLIGFLNSLIH 135
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544349   505 IFGISsymKVSICLPMDID------SPLSQL-----YVMSLLVLnVLAFVVICGC-------YTHIYLTVRnpNITSSS 565
Cdd:cd13954 136 TVLIS---QLPFCGSNVINhffcdiPPLLKLscsdtSLNELVIF-ILAGFVGLGSflltlvsYIYIISTIL--KIPSAE 208
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
364-634 9.37e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 38.67  E-value: 9.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   364 ILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKteyhnyaiDWQTG-AGC 442
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITT--------RWIFGdAFC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   443 D-AAGFFTVFASElSVYTLTAITLERWHTIthaMQLECKVQLRHAASIMLVGWIFAFAVAlFPIFGISSYMKVSICLPMD 521
Cdd:cd15404  74 RvSAMFFWLFVME-GVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVA-FPLAVGSPDLQIPSRAPQC 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349   522 I----DSPLSQLYVMSL-LVLNVLAFVVICGCYTHIYLTVRnpnitssSSDTKIAKRMAMLIFTDFLCMAPISFFAISAS 596
Cdd:cd15404 149 VfgytTNPGYQAYVILImLIFFFIPFMVMLYSFMGILNTVR-------SFKTRAFTTILILFIVFTVCWAPFTTYSLVAT 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 544349   597 LKVPLITVSK----SKILLVLFYpINSCANPFLYAIFTKNFR 634
Cdd:cd15404 222 FNSHFYHKHNffeiSTWLLWLCY-LKSALNPLIYYWRIKKFR 262
LRR_5 pfam13306
Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This ...
84-216 9.81e-03

Leucine rich repeats (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 433104 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 9.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544349      84 EVIEANVFSNLpKLHEIRIEkaNNLLYIDPDAFQNLPNLRYLLISNTgikhlpaVHKIQ-------SLQKVllDIQDNIN 156
Cdd:pfam13306   1 TSIGSYAFYNC-SLTSITIP--SSLTSIGEYAFSNCTSLKSITLPSS-------LTSIGsyafyncSLTSI--TIPSSLT 68
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544349     157 ihTVERNSFMGLS-FESMTVWlskNGIQEIHNCAFNGTQLDELNLSdnSNLEELPNDVFQG 216
Cdd:pfam13306  69 --SIGEYAFSNCSnLKSITLP---SNLTSIGSYAFSNCSLKSITIP--SSVTTIGSYAFSN 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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