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Conserved domains on  [gi|544419009|ref|XP_005549187|]
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actin-related protein 2/3 complex subunit 1B [Macaca fascicularis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.43e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319  275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        250
                 ....*....|....
gi 544419009 251 TFITDNSLVAAGHD 264
Cdd:COG2319  337 AFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.43e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319  275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        250
                 ....*....|....
gi 544419009 251 TFITDNSLVAAGHD 264
Cdd:COG2319  337 AFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-264 8.85e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRInrAARCVRWAPNENKFAVGSGSRVISIcy 124
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 125 feqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS-AYIKEVEERPAPTPWGSKMPF-GELMFES 198
Cdd:cd00200   78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFsPDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 199 SSSC----------------------GWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDN 256
Cdd:cd00200  152 SSSQdgtiklwdlrtgkcvatltghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231


                 ....*...
gi 544419009 257 SLVAAGHD 264
Cdd:cd00200  232 YLLASGSE 239
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 4.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.62e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 544419009    41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
42-79 5.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 544419009   42 WTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.43e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319  275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        250
                 ....*....|....
gi 544419009 251 TFITDNSLVAAGHD 264
Cdd:COG2319  337 AFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
15-262 4.74e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 4.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVilR 94
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--G 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISICyfeqENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAyik 174
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSADGTVRLW----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--- 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 175 eveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFIT 254
Cdd:COG2319  318 ---------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                 ....*...
gi 544419009 255 DNSLVAAG 262
Cdd:COG2319  383 DGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 3.14e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKWtkVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLL--LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLatgkLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 171 ayikeveerpAPTpwgskmpfGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319  233 ----------LAT--------GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                        250
                 ....*....|....
gi 544419009 251 TFITDNSLVAAGHD 264
Cdd:COG2319  295 AFSPDGKLLASGSD 308
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-264 8.85e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRInrAARCVRWAPNENKFAVGSGSRVISIcy 124
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 125 feqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS-AYIKEVEERPAPTPWGSKMPF-GELMFES 198
Cdd:cd00200   78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFsPDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 199 SSSC----------------------GWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDN 256
Cdd:cd00200  152 SSSQdgtiklwdlrtgkcvatltghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231


                 ....*...
gi 544419009 257 SLVAAGHD 264
Cdd:cd00200  232 YLLASGSE 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-265 4.71e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009   4 HSFLVEPISCHAWNKdrsQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkg 83
Cdd:cd00200   50 HTGPVRDVAASADGT---YLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  84 RTWKPTLVILRINRAARCVRWAPNeNKFAVGSGS-RVISICyfeqENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQdGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 163 DFKCRIFSAYikeveerpaptpwgSKMPFGELmfesSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLAS 242
Cdd:cd00200  198 DGTIKLWDLS--------------TGKCLGTL----RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        250       260
                 ....*....|....*....|....
gi 544419009 243 ETLPLLALTFITDNS-LVAAGHDC 265
Cdd:cd00200  260 HTNSVTSLAWSPDGKrLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-226 3.43e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 3.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009   9 EPISCHAWNKDRSQIAICPNNHEVHIYEksGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKP 88
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGKC 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISIcyFEQENDWWVCKHIKKpiRSTVLSLDWHPNNVLLAAGSCDFKCRI 168
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRV 245

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 544419009 169 FSAYIkeveerpaptpwgskmpfGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTV 226
Cdd:cd00200  246 WDLRT------------------GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-170 8.53e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 8.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  10 PISCHAWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPT 89
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  90 LVilRINRAARCVRWAPNENKFAVGSGSRVISIcyfeqendW-WVCKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFK 165
Cdd:cd00200  215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 544419009 166 CRIFS 170
Cdd:cd00200  285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 2.26e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKWtkVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKgrTWKPTLVILR 94
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTG 328

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544419009  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendW----WVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRL--------WdlatGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
59-264 4.39e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 4.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009  59 DWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRinRAARCVRWAPNENKFAVGSGSRVISIcyfeQENDWWVCKHIK 138
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544419009 139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAyikeVEERPAPTPWGSKmpfgelmfesssscGWVHGVCFSASGSRVA 218
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTGHT--------------GAVRSVAFSPDGKTLA 136

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 544419009 219 WVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHD 264
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 4.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.62e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 544419009    41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
42-79 5.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 544419009   42 WTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-79 3.73e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 3.73e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544419009   9 EPISCHAWNKDRSQIAICPNNHEVHIYekSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
15-83 3.74e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.74e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544419009  15 AWNKDRSQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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