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Conserved domains on  [gi|544584724|sp|Q8VDB2|]
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RecName: Full=Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 12 homolog; AltName: Full=Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; AltName: Full=Mannosyltransferase ALG12 homolog

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 17-405 2.26e-28

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 116.31  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   17 LLVTVATIHLVICPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplviAAFSSPVVYVLSLLEVSK 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   94 FYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  167 --QRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLT----VAVDSYFWRYLVWPE 240
Cdd:pfam03901 157 snYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  241 GVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTYALALPSLGFVALYSLLPHKELRFI 314
Cdd:pfam03901 237 LNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  315 IYTFPVLNIMAARGCTYILNKKswpYKVRAMLVTGHILVnVAYTATSLYVSHFNYPGGV-----AMQQLHELVPPQTDVL 389
Cdd:pfam03901 317 YPVYPLILLSAAIALTRLSRRS---WKVRKKLSLLFLLL-FFNVSLARLFGLVHQYGAPlavydVMSFLNETPRENRNPA 392

                         410       420
                  ....*....|....*....|.
gi 544584724  390 -----LHIDVAAAQTGVSRFL 405
Cdd:pfam03901 393 gppvnVCIGMECYSTPSSFFL 413
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-405 2.26e-28

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 116.31  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   17 LLVTVATIHLVICPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplviAAFSSPVVYVLSLLEVSK 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   94 FYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  167 --QRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLT----VAVDSYFWRYLVWPE 240
Cdd:pfam03901 157 snYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  241 GVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTYALALPSLGFVALYSLLPHKELRFI 314
Cdd:pfam03901 237 LNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  315 IYTFPVLNIMAARGCTYILNKKswpYKVRAMLVTGHILVnVAYTATSLYVSHFNYPGGV-----AMQQLHELVPPQTDVL 389
Cdd:pfam03901 317 YPVYPLILLSAAIALTRLSRRS---WKVRKKLSLLFLLL-FFNVSLARLFGLVHQYGAPlavydVMSFLNETPRENRNPA 392

                         410       420
                  ....*....|....*....|.
gi 544584724  390 -----LHIDVAAAQTGVSRFL 405
Cdd:pfam03901 393 gppvnVCIGMECYSTPSSFFL 413
PLN02816 PLN02816
mannosyltransferase
 123-326 1.51e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 53.88  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724 123 FGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAW-----------LQRRWALFVwlsAFVIIGFRAELAML 191
Cdd:PLN02816 144 YGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWpcirdssidypVNRKWGLVI---AALACAIRPTSAVI 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724 192 LGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPR 271
Cdd:PLN02816 221 WLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 300

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544584724 272 GLGCSLLFIPLGAVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAA 326
Cdd:PLN02816 301 MLFTFTPFSIAGIIKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSG 355
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-405 2.26e-28

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 116.31  E-value: 2.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   17 LLVTVATIHLVICPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplviAAFSSPVVYVLSLLEVSK 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724   94 FYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  167 --QRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLT----VAVDSYFWRYLVWPE 240
Cdd:pfam03901 157 snYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  241 GVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTYALALPSLGFVALYSLLPHKELRFI 314
Cdd:pfam03901 237 LNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724  315 IYTFPVLNIMAARGCTYILNKKswpYKVRAMLVTGHILVnVAYTATSLYVSHFNYPGGV-----AMQQLHELVPPQTDVL 389
Cdd:pfam03901 317 YPVYPLILLSAAIALTRLSRRS---WKVRKKLSLLFLLL-FFNVSLARLFGLVHQYGAPlavydVMSFLNETPRENRNPA 392

                         410       420
                  ....*....|....*....|.
gi 544584724  390 -----LHIDVAAAQTGVSRFL 405
Cdd:pfam03901 393 gppvnVCIGMECYSTPSSFFL 413
PLN02816 PLN02816
mannosyltransferase
 123-326 1.51e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 53.88  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724 123 FGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAW-----------LQRRWALFVwlsAFVIIGFRAELAML 191
Cdd:PLN02816 144 YGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWpcirdssidypVNRKWGLVI---AALACAIRPTSAVI 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544584724 192 LGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPR 271
Cdd:PLN02816 221 WLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLV 300

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544584724 272 GLGCSLLFIPLGAVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAA 326
Cdd:PLN02816 301 MLFTFTPFSIAGIIKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSG 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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