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Conserved domains on  [gi|551490478|ref|XP_005796811|]
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alpha-2,8-sialyltransferase 8F-like [Xiphophorus maculatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 80-351 1.05e-159

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23971:

Pssm-ID: 480271  Cd Length: 271  Bit Score: 448.24  E-value: 1.05e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  80 YQKFRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCG 159
Cdd:cd23971    3 HQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 160 KMIDSAEFVIRCNLPPLSNgyEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPVSL 239
Cdd:cd23971   83 REIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 240 RAFYTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNHYY 319
Cdd:cd23971  161 RALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHYY 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551490478 320 DDRKTKTKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23971  240 DNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 80-351 1.05e-159

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 448.24  E-value: 1.05e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  80 YQKFRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCG 159
Cdd:cd23971    3 HQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 160 KMIDSAEFVIRCNLPPLSNgyEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPVSL 239
Cdd:cd23971   83 REIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 240 RAFYTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNHYY 319
Cdd:cd23971  161 RALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHYY 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551490478 320 DDRKTKTKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23971  240 DNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 98-346 2.68e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.83  E-value: 2.68e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478   98 TITQANTPVGTKLVYdGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLs 177
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  178 NGYEKHVGINTDLVTANP-SILMEKFGALMGR--RRKFVESLRSY--GDSLLLLPAFSFGHNTPVSLRAFYTLEDFESPV 252
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  253 RP---IFFNPGYLHNLALFW-RSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfhpySFQTLTNHYYDDRKTK--- 325
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 551490478  326 -TKFHAMPDEFNHLLRLHSQGV 346
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 80-351 1.05e-159

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 448.24  E-value: 1.05e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  80 YQKFRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCG 159
Cdd:cd23971    3 HQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 160 KMIDSAEFVIRCNLPPLSNgyEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPVSL 239
Cdd:cd23971   83 REIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 240 RAFYTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNHYY 319
Cdd:cd23971  161 RALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHYY 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551490478 320 DDRKTKTKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23971  240 DNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 78-351 8.18e-117

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 339.42  E-value: 8.18e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  78 EPYQKFRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSS 157
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 158 CGKMIDSAEFVIRCNLPPLSNGYEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPV 237
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 238 SLRAFYTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfHPYSFQTLTNH 317
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFS-KNTEGKPISHH 239

                        250       260       270
                 ....*....|....*....|....*....|....
gi 551490478 318 YYDDRKTKTKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23991  240 YYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 98-346 2.68e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.83  E-value: 2.68e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478   98 TITQANTPVGTKLVYdGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLs 177
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  178 NGYEKHVGINTDLVTANP-SILMEKFGALMGR--RRKFVESLRSY--GDSLLLLPAFSFGHNTPVSLRAFYTLEDFESPV 252
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  253 RP---IFFNPGYLHNLALFW-RSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfhpySFQTLTNHYYDDRKTK--- 325
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 551490478  326 -TKFHAMPDEFNHLLRLHSQGV 346
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 81-351 1.03e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 288.39  E-value: 1.03e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  81 QKFRSQLSAKCHGLEKAtITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGK 160
Cdd:cd23963    4 DKFRKELERLLNTRKLF-LTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 161 MIDSAEFVIRCNLPPLSnGYEKHVGINTDLVTANPSILMEKFGALMGR--RRKFVESLRSYGDSLLLLPAFSFGHNTPVS 238
Cdd:cd23963   83 EIDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKKNrdRDKFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 239 LRAFYTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTiRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHY 318
Cdd:cd23963  162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPYHY 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 551490478 319 YDDRKTKT--KFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23963  240 YDDLSPSTknKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 83-350 2.98e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 284.81  E-value: 2.98e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  83 FRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMI 162
Cdd:cd23990    6 FKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 163 DSAEFVIRCNLPPLSNGYEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPVSLRAF 242
Cdd:cd23990   86 DSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 243 YTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNHYYDDR 322
Cdd:cd23990  166 YVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNP-SGIFITHHYYDNV 244

                        250       260
                 ....*....|....*....|....*...
gi 551490478 323 KTKTKFHAMPDEFNHLLRLHSQGVLKLH 350
Cdd:cd23990  245 KPRPGFHAMPSEIFNFLHMHSRGILRVH 272
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 83-351 7.16e-94

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 280.95  E-value: 7.16e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  83 FRSQLSAKCHGLEKATITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPnKTWHTCAVVGNGGILANSSCGKMI 162
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 163 DSAEFVIRCNLPPLSNGYEKHVGINTDLVTANPSILMEKFGALMGRRRKFVESLRSYGDSLLLLPAFSFGHNTPVSLRAF 242
Cdd:cd23989   85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 243 YTLEDFESPVRPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDR 322
Cdd:cd23989  165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNV 243

                        250       260
                 ....*....|....*....|....*....
gi 551490478 323 KTKTKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23989  244 LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 135-351 1.08e-68

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 217.26  E-value: 1.08e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 135 PFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDLVTANPSILMEKFGALMGR--RRKF 212
Cdd:cd23970   62 PFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTE-GFEKDVGRKTNLTTFNPSILEKYYNNLLTIqdRNNF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 213 VESLRSYGDSLLLLPAFSFGHNTPVslraFYTLEDFESPVRPiFFN-----PG-YLHNLALFWRSQGLRTIRLSTGIIMT 286
Cdd:cd23970  141 FLSLKKLDGAILWIPAFFFHTSATV----TRTLVDFFVEHRG-QLKvqlawPGnIMQHVNRYWKTKHLSPKRLSTGILMY 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 287 SLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDRKTK-----TKFHAMPDEFNHLLRLHSQGVLKLHL 351
Cdd:cd23970  216 TLASAICEEIHLYGFWPFGFDPTG-TPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 98-350 1.35e-66

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 211.50  E-value: 1.35e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  98 TITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLS 177
Cdd:cd23969   21 SVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 178 nGYEKHVGINTDLVTANPSILMEKFGALMGR--RRKFVESLRSYGDSLLLLPAFSfghNTPVSLRAFYTLE---DFESPV 252
Cdd:cd23969  101 -GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFV---SKGGEEHVQWTNEiilKHKLNV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 253 RPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDRK--TKTKFHA 330
Cdd:cd23969  177 KTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNG-RAVKYHYYDNRKylTTARPHK 255

                        250       260
                 ....*....|....*....|
gi 551490478 331 MPDEFNHLLRLHSQGVLKLH 350
Cdd:cd23969  256 MPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 98-349 6.08e-52

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 173.60  E-value: 6.08e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478  98 TITQANTPVGTKLVYDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLS 177
Cdd:cd23988   21 SVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 178 nGYEKHVGINTDLVTANPSILMEKFGALMGR--RRKFVESLRSYGDSLLLLPAFSF-GHNTPVSLRAFYTLEDfESPVRP 254
Cdd:cd23988  101 -EFAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVkGGEKHVEWVNALILKN-KLKVRT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 255 IFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPF--DFHPYSFQTltnHYYDDRKTK----TKF 328
Cdd:cd23988  179 AYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkDANGNPVKY---HYYDDLKYRyfsnAGP 255

                        250       260
                 ....*....|....*....|.
gi 551490478 329 HAMPDEFNHLLRLHSQGVLKL 349
Cdd:cd23988  256 HRMPLEFKTLNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 112-351 3.42e-48

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 163.96  E-value: 3.42e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 112 YDGEKKRTLQVNLEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSNgYEKHVGINTDLV 191
Cdd:cd23987   35 YVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGTKTDLV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 192 TANPSILMEKFGALMGR--RRKFVESLRSYGDSLLLLPAF-SFGHNTPVSLRAFYTLEDFESpVRPIFFNPGYLHNLALF 268
Cdd:cd23987  114 TMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAFmAKGGEERVEWVNDLILKHHIN-VRTAYPSLRLLHAVRGY 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 269 WRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfHPYSFQTLTNHYYDDRK----TKTKFHAMPDEFNHLLRLHSQ 344
Cdd:cd23987  193 WLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFP-RDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKALKNLHQQ 271


                 ....*..
gi 551490478 345 GVLKLHL 351
Cdd:cd23987  272 GALKLTV 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 144-341 9.69e-30

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 112.84  E-value: 9.69e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDLVTANPSILmekfGALMGRRRKFVESLRSYGDSL 223
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWA----GFYLRGPRCGCHPLPLEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 224 LLLPAFSFGHNTPVSLRAFYtledfeSPVRPIFFNP--GYLHNLA---LFW--RSQGLRTIRLSTGIIMTSLALELCDNV 296
Cdd:cd19952   76 LILSRAAAADFKRLKRRKKR------HDNAVLLLTDpaPDLLSYVrkrLEKlgLKSFFGGNAPSSGLLAVLLALQLCDSV 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 551490478 297 QLYGFWPFDFHPYSFQtltNHYYDDRKT--KTKFHAMPDEFNhLLRL 341
Cdd:cd19952  150 DLYGFGVDSGHAPKVP---YHYYDLVEAeeGTAVHSFDLEAE-LLRA 192
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 143-352 7.22e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 97.13  E-value: 7.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGINTDL-------VTANPSILMEK-FGAL-MGRRRKFV 213
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFyvhtahsITSSLMILQKRgFKNIpQDKDIKYI 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 214 ---ESLRSYG--DSLLLLPAFSFGHNTPVSLRAFYTlEDFeSPVRPIFFNPGYLHNLA-LFWRSQGLRTI-----RLSTG 282
Cdd:cd23973  164 lfpEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYFS-GDF-TEDKYLVLHPDFLRYVKnRFLRSKTLKGKywaiyRPTTG 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551490478 283 IIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKFHAMPD---EFNHLLRLHSQGVLKLHLG 352
Cdd:cd23973  242 AFLLLTALHLCDTVSAYGFITEDYRKYP-----DHYYDKKKTKLVFYINHDfrlEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 143-350 8.10e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 85.39  E-value: 8.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPpLSNGYEKHVGINTDLVTANP-SILMEK-FGALMGRRRKFV-----ES 215
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHA-LTKGFEKDVGTKTSFYTFFPeSLHNSLlKHVPQDKDTKYLfipfkIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 216 LRSYGDSLLL---LPAFSFGHNTPVSLRA-FYTLEDFESpVRPIFFNpgYLHNlalFW-RSQglRTIRLSTGIIMTSLAL 290
Cdd:cd23964  163 DYDYLDAVLSgkpVPDGCDKGKRPPPLFGpKLNATNVRL-LHPDFIR--YLFN---RWlNSS--TSYRPTTGALMLLTAL 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551490478 291 ELCDNVQLYGfwpFDFHPYSfqtlTNHYYDD-RKTKTKF---HAMPDEFNHLLRLHSQGVLKLH 350
Cdd:cd23964  235 HTCDQVSVYG---FGYDPRF----SLHYYDKtFVKFTVFyanHDFTNERKLWRKLHEEGIINLY 291
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 144-325 2.82e-17

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 79.26  E-value: 2.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDLVTANPSilmekfGAlmgrrrkFVESLRSYGDSL 223
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVK-GYEKDVGSKTTFRMFYPE------SA-------FRDPEEYDSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 224 LLLPAFSfghntPVSLRAFYTLEDFESPVRPIFF------------------NPGYLHNLAL----FWRSQGLRTIRLST 281
Cdd:cd23967   71 LVLVPFK-----SMDLLWLQAVIKGKKPNGKGGFwkkiatsvpkppkkirilNPYILQEAAFdligLPMNGKQGKNVPTT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 551490478 282 GIIMTSLALELCDNVQLYGFWpfdfHPYSFQTLTNHYYDDRKTK 325
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAGFG----YDPSDPNAPLHYYDSLTMK 185
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 144-351 1.07e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 79.80  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGINTDLVTANPSILMekfgalmgrrrkfvESLRSYG--- 220
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLM--------------NSLRAYAgvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 221 --------------------DSLLLLPAFSfghNTPVS---------LRAF---YTLEDFESpVRPIFFNpgYLHNlaLF 268
Cdd:cd23974  152 fngppqsketryiflpdhdrDYLLVKAALT---HTPIDrgrdkskrpSKYFgkdVTAEKFKI-YHPDFIR--YLRN--RF 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 269 WRSQGLRT-----IRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKFHAmpdefNHLLR--- 340
Cdd:cd23974  224 LWSPILNTkqrdiYRPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYS-----DHYYDKTYHKVVFYA-----NHDLRlem 293

                        250
                 ....*....|....*.
gi 551490478 341 -----LHSQGVLKLHL 351
Cdd:cd23974  294 qlwqkLHKAGLIKLYM 309
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 116-342 2.12e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.38  E-value: 2.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 116 KKRTLQVNLEIFSTFFKG-----HPFPN------KTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHV 184
Cdd:cd23968    9 KKAAPFSTLRKTTSPFKDllslrYPFPEsslentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK-GFEKDV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 185 GINTDLVTANPSILMekfgalmgRRRKFVESLRSYGDSLLLlpAFSFGHNTpVSLRAFYTLEDFES-----------PVR 253
Cdd:cd23968   88 GSKTTLRLINSQILS--------KPEFNFLTDPLYRNVTLL--VWDPSSYN-VNLEKWYKKPDFDFfpnyikyrrrhPEE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 254 PIFF-NPGYLHNLalfW----RSQGLRTIRL--STGIIMTSLALELCDNVQLYGFWPfdfhpySFQTLTN-HYYDDRKTK 325
Cdd:cd23968  157 PFYLiDPRFLWRL---WdilqEYTPEKIKPNppSSGFIGIVLMLHLCDWVDVYEYVP------SVRQTDRcHYYDVEKDL 227

                        250       260
                 ....*....|....*....|.
gi 551490478 326 TK----FHAMPDEFNHLLRLH 342
Cdd:cd23968  228 ACtlgaWHPLAAEKLLVRHLN 248
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 143-321 5.75e-15

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.86  E-value: 5.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDLVTANP-SIlmekfgalmgrrrkFVESLRSYGD 221
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPeSI--------------FSDPSHYDPN 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 222 SLLLLPAFS----------FGHNtPVSLRAFYTledfeSPVRPIFF--------NPGYLHNLALFWRSQGLR------TI 277
Cdd:cd23984   69 TTVVLIPFKphdlrwlldlLMGK-KVSAKGFWK-----KPALNLIYkpnqirilNPFILRIAAYELLHFPKRfpkekkPK 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 551490478 278 RLSTGIIMTSLALELCDNVQLYGFwpfdfhPYSFQTLTN--HYYDD 321
Cdd:cd23984  143 HPTTGIIAITLALHICNEVHIAGF------KYDFSNLNStlHYYGN 182
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 128-350 9.47e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.09  E-value: 9.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 128 STFFKGHPFPNKTWHtCAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGINTDL------VTANPSILMEK 201
Cdd:cd23972   70 AKLFFPRDTPGKCIR-CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygftvnTMKNSLISYWN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 202 FGAL-----MGRRRKFVES-LRSY---GDSLLLLPAFSfGHNTPVSLRAFYTLEdfESPVRPIFFNPGYLHNLA-LFWRS 271
Cdd:cd23972  148 LGFTrtpqgQDLQYIFIPSdIRDYvmlRSAILGVPVPE-GLDKGDRPHKYFGPE--ASAKKFKLLHPDFISYLTdRFLKS 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 272 QGLRT-----IRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKFHAMPD---EFNHLLRLHS 343
Cdd:cd23972  225 KLLNThyghlYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFS-----DHYYERKKKPLVFYANHDmllEAALWRRLHK 299


                 ....*..
gi 551490478 344 QGVLKLH 350
Cdd:cd23972  300 AGILQLY 306
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 143-341 5.97e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 69.69  E-value: 5.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDLVTANPsilmekfgalmgRRRKFVESLRSYGDS 222
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIRLFYP------------ESAQFDPGIENDPDT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 223 LLLLPAFSfghntPVSLRAFYTLEDFESPVRPIFF-----------------NPGYLHNLALFWRS---QGLRTIRLSTG 282
Cdd:cd23982   71 LLVLVPFK-----PLDFYWLYEILSNEKRVRKGFWkqppriwdanpkqirilNPYYTYVAATKLLQvpgQRKKKQKPTTG 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551490478 283 IIMTSLALELCDNVQLYGF-WPFDFHPYSFQtltnHYYDD---RKTKTKFHAMPDEFNHLLRL 341
Cdd:cd23982  146 LLAITLALHLCDEVHIAGFgYPDNGNSNQPI----HYYNQitlKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 143-350 6.90e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 71.16  E-value: 6.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDlvtanpsilmekfgalmgRRRKFVESLRSY--G 220
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTK-GFEKDVGSKTT------------------HHFMYPESAVDLdpG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 221 DSLLLLP-----------AFSFGH--NTPVSLRAFYTLedfeSPVRPIFFNPGYLHNLALFW-RSQGlrtiRL-STGIIM 285
Cdd:cd23966  140 VHLVLVPfkvldlqwlisALTTGEitRTYTPVKRFIKA----DKDKVLVINPAFIKYVHDNWtEHHG----RYpSTGFLA 211

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551490478 286 TSLALELCDNVQLYGF-------WpfdfhpysfqtltNHYYDD-----RKTKTKFHAMPDEFNHLLRLHSQGVLKLH 350
Cdd:cd23966  212 LIFALHICDEVSVFGFgadskgnW-------------HHYWEKnrsagAFRKTGVHDADFESDIIKKLAKEGKIRVY 275
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 142-325 1.02e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 66.88  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 142 HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDL-VTANPSIlmekfgALMGRRRKFVESLRSYG 220
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTR-GYEKDVGRRTTIrVVSHSSL------PRLLRNAILLLAGTRAP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 221 DSLLLlpafsFGHNTPVSLRAFYT------LEDFESPVRPIFFNPG-YLHNLALFWRSQGL-RTIR---LSTGIIMTSLA 289
Cdd:cd23965   75 TVVVF-----WGPETKMNKDGAGKynllrsLSKKYPDVEFYSLTPEkMDYADELFEKETGKsRIKSgtwLSTGWFTMLLA 149

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 551490478 290 LELCDNVQLYGFWPFDF---HPYSfqTLTNHYYDDRKTK 325
Cdd:cd23965  150 LDVCDEIKVYGMVPENYcreHPNS--KVPYHYYEPGGLK 186
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 144-333 4.25e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 55.90  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLsNGYEKHVGINTDLVTANPSilmekfGALMG-----RRRKFVESLRS 218
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPE------GAPKSeqeydPTSLFVAVLFK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 219 YGDSLLLLPAFSfghNTPVSL--RAFYTLEDFES-PVRPIFF---NPGYLHNLAL------------FWRSQGLRTIrls 280
Cdd:cd23983   78 SVDFAWLKAMVK---KEPLSFwsRLFFWKEVADSiPLKPSQFrilNPLIIKETALdilqypepqsrlWGWDKNVPTL--- 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 551490478 281 tGIIMTSLALELCDNVQLYGFwpfdfhPYSFQTLTN--HYYDDRKTKT-KFHAMPD 333
Cdd:cd23983  152 -GVTAVVLATHLCDEVSLAGF------GYDLSQPHAplHYYDSVCMAAmNTQTMHN 200
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 144-201 6.03e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 55.31  E-value: 6.03e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLsNGYEKHVGINTDLVTANPSILMEK 201
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQK 61
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 125-301 1.13e-08

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 55.65  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 125 EIFSTFFKGHP--FPNKTW-----HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDL------- 190
Cdd:cd23979   57 EVLSKLFQIIPgeNPYRSWdpsrcRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTTHhfmypes 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 191 ---VTANPSILMEKFGALmgrrrkfveslrsygDSLLLLPAFSFGHntpvsLRAFYtledfeSPVRPIF---------FN 258
Cdd:cd23979  136 aknLPANVSFVLVPFKTL---------------DLLWITSALSTGQ-----IRFTY------APVKQFLrvdkdkvqiYN 189

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 551490478 259 PGYLHNLALFWRSQGLRTIrlSTGIIMTSLALELCDNVQLYGF 301
Cdd:cd23979  190 PAFFKYIHDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGF 230
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 142-322 5.79e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 52.93  E-value: 5.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 142 HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGINTDL-VTANPSIlmekFGALmgRRRKFVESLRSYG 220
Cdd:cd23978    2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV----YRVL--RRPQEFLNRTPET 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 221 DSLLLLPAFSFGHNTPVSL--------RAFYTLEDFE-SPVRPIFFNpgylhnlALFWRSQGLRTIR----LSTGIIMTS 287
Cdd:cd23978   75 TLIFWGPPNKMQKDGKSNLfriiqrasMTFPNMSAFVvSPRRMRQFD-------DLFRGETGRDRKKshswLSTGWFTMV 147

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 551490478 288 LALELCDNVQLYGFWPFDF--HPYSFQTLTNHYYDDR 322
Cdd:cd23978  148 IAVELCDNVHVYGMVPPNYcsKRPTPKKMPYHYYEPK 184
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 143-320 9.39e-08

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 52.53  E-value: 9.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDLVTANPSILMEKfgalmgrRRKFVESlRSYGDS 222
Cdd:cd23986   51 SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNP-------NHHFIDS-SLYKDV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 223 LLLL--PA-FSfghntpVSLRAFYTLEDF-----------ESPVRPIF-FNPGYLHNLALFWRSQGLRTIR---LSTGII 284
Cdd:cd23986  122 ILVAwdPApYS------ANLHKWYKKPDYnlftpyvqyrkRNPNQPFYiLHPKFIWQLWDIIQENTQEKIQpnpPSSGFI 195

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 551490478 285 MTSLALELCDNVQLYgfwpfDFHPYSFQTLTNHYYD 320
Cdd:cd23986  196 GILIMMSMCREVHVY-----EYIPSVRQTDLCHYHE 226
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 143-301 3.27e-07

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 51.04  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDLVTANPsilmekfgalmgrrrkfvESLRSYGD- 221
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYP------------------ESFRELAQn 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 222 -SLLLLPAFSFGHNTPVSLRAFYTLEDFESPV---------RPIFFNPGYLHNLALFWRSQGLRTIrlSTGIIMTSLALE 291
Cdd:cd23980  144 vSMILVPFKTLDLEWVISATTTGTISHTYVPVprkikvkkeKILIYHPAFIKYVFDRWLQGHGRYP--STGILSVIFSLH 221

                        170
                 ....*....|
gi 551490478 292 LCDNVQLYGF 301
Cdd:cd23980  222 VCDEVDLYGF 231
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 119-319 2.48e-06

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 48.16  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 119 TLQVNLEIFSTFFKGHPFPNKT-------WHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVG------ 185
Cdd:cd23985   16 MLEGTDFPFNTSEWEGYLPKKSlreevgpLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGtkttir 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 186 -INTDLVTANpsilmekfgalmgrRRKFV-ESLRSYGDSLLLLPAfSFGHNTPvslrafytlEDFESPVRPIFFN----- 258
Cdd:cd23985   95 lINSQLVTTE--------------KHKFLkDSLYNEGILIVWDPA-PYHSDIP---------EWYKNPDYNFFENyktyr 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551490478 259 ------PGYLHNLALFW------RSQGLRTIRL---STGIIMTSLALELCDNVQLYgfwpfDFHPYSFQTLTNHYY 319
Cdd:cd23985  151 rlnpnqPFYILHPQMQWelwdiiQENSPEEIQPnppSSGMLGIILMMTLCDQVDVY-----EFLPSKRKTDVCHYY 221
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 143-320 9.19e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 46.40  E-value: 9.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 143 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDL-VTANPSI--LMEKFGALMGRRRKFV------ 213
Cdd:cd23976   17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSIqrILRNRNELLNVSQGTVfifwgp 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551490478 214 -ESLRSYGDSLLLlpafsfgHNTPVSLRAFYTLEDFespvrpIFFNPGYLHNLALFWRSQGL-RTIR---LSTGIIMTSL 288
Cdd:cd23976   96 sNYMRRDGKGLVY-------NNLQLMNQILPKLKVY------TITRHKMLQFDELFKRETGKdRKISntwLSTGWFTMII 162

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 551490478 289 ALELCDNVQLYGFWPFDF-----HPysfqTLTNHYYD 320
Cdd:cd23976  163 ALELCDRINVYGMVPPDFcrdpnHP----SVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 144-190 6.13e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 40.62  E-value: 6.13e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 551490478 144 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGINTDL 190
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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