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Conserved domains on  [gi|55769546|ref|NP_060376|]
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p21-activated protein kinase-interacting protein 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-275 1.54e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  41 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 117
Cdd:cd00200  50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 118 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 191
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 192 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 268
Cdd:cd00200 206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                ....*..
gi 55769546 269 GFIKMWK 275
Cdd:cd00200 283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-275 1.54e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  41 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 117
Cdd:cd00200  50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 118 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 191
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 192 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 268
Cdd:cd00200 206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                ....*..
gi 55769546 269 GFIKMWK 275
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
26-277 6.17e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.17e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  26 DHEQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAED 102
Cdd:COG2319 148 DLATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSAD 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 103 GLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVV 181
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLA 304

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 182 I--IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfei 256
Cdd:COG2319 305 SgsDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS--- 381

                       250       260
                ....*....|....*....|.
gi 55769546 257 PEHHVIVSASSDGFIKMWKLK 277
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 5.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55769546    112 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-271 9.09e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546   54 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 122
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  123 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 197
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  198 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 269
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 55769546  270 FI 271
Cdd:PLN00181 722 YI 723
WD40 pfam00400
WD domain, G-beta repeat;
113-151 1.12e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.12e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55769546   113 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-275 1.54e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  41 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 117
Cdd:cd00200  50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 118 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 191
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 192 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 268
Cdd:cd00200 206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                ....*..
gi 55769546 269 GFIKMWK 275
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
26-277 6.17e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.17e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  26 DHEQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAED 102
Cdd:COG2319 148 DLATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSAD 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 103 GLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVV 181
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLA 304

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 182 I--IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfei 256
Cdd:COG2319 305 SgsDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS--- 381

                       250       260
                ....*....|....*....|.
gi 55769546 257 PEHHVIVSASSDGFIKMWKLK 277
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
28-282 1.64e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 1.64e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  28 EQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLIC 106
Cdd:COG2319  66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgKTLASGSADGTVR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 107 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNA-HIVEWSPRGeQYVVI--I 183
Cdd:COG2319 146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDG-KLLASgsA 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 184 QNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHH 260
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVaFS---PDGK 301

                       250       260
                ....*....|....*....|..
gi 55769546 261 VIVSASSDGFIKMWKLKQDKKV 282
Cdd:COG2319 302 LLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
26-282 3.47e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 3.47e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  26 DHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF-YGNRHLISGAEDGL 104
Cdd:COG2319  22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 105 ICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKQNAHIVE---WSPRGeQYVV 181
Cdd:COG2319 102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTsvaFSPDG-KLLA 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 182 I--IQNKIDIYQLDTASISGTITN-EKRISSVKFLSES-VLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfei 256
Cdd:COG2319 179 SgsDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVaFS--- 255

                       250       260
                ....*....|....*....|....*.
gi 55769546 257 PEHHVIVSASSDGFIKMWKLKQDKKV 282
Cdd:COG2319 256 PDGRLLASGSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-151 4.16e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 4.16e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  37 THHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKW 113
Cdd:cd00200 172 TLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTG 251

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55769546 114 ECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-156 5.82e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 5.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  39 HAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWEC 115
Cdd:cd00200 132 RGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKC 211

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55769546 116 LKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 156
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-282 1.17e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.17e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  74 EHGALVHHSGTITCLKF-YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFsPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 153 VEGRSAFIknikQNAHI-----VEWSPRGeQYVV--IIQNKIDIYQLDTASISGTITN-EKRISSVKFL-SESVLAVAGD 223
Cdd:cd00200  81 ETGECVRT----LTGHTsyvssVAFSPDG-RILSssSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSpDGTFVASSSQ 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 224 EEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWKLKQDKKV 282
Cdd:cd00200 156 DGTIKLWDLRTGKCVATLTGHTGEVNSVaFS---PDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 5.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55769546    112 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 54-205 6.80e-06

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 47.72  E-value: 6.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  54 FVVTGSKDETIHIYDMK-----KKIEHGALVH-HSGTITCLKFYGNrhlISGAEDGLICIWDAKKWECLKSIKAhKGQVT 127
Cdd:cd20718 210 FIVASQGSNTMWVLDLKtgkvvARIPTGKTPHpGPGATWGRKGVTA---TPHLGEGIVTVWDLDTWKPVKYIPT-PGPGR 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546 128 FLSIHPSGKLalsVGTDKTLRTWN-----LVEGRS----AFIKNIKQN-AHIVEWSPRGEqYVVII---QNKIDIYQLDT 194
Cdd:cd20718 286 FVRTHPSSPY---VWADTVFGPENadeiyVIDKETlkvvKTLIPKPGKrALHPEFTRDGK-YVYVSvwdGGEVVVYDAET 361

                       170
                ....*....|.
gi 55769546 195 ASISGTITNEK 205
Cdd:cd20718 362 LELVKRIPAET 372
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-271 9.09e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546   54 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 122
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  123 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 197
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55769546  198 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 269
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 55769546  270 FI 271
Cdd:PLN00181 722 YI 723
WD40 pfam00400
WD domain, G-beta repeat;
113-151 1.12e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.12e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55769546   113 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 1.54e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 55769546     78 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 109
Cdd:smart00320   8 LKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
78-109 4.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.19e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 55769546    78 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 109
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-275 4.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 55769546    234 SLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWK 275
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVaFS---PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-274 7.66e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55769546   237 CLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMW 274
Cdd:pfam00400   3 LLKTLEGHTGSVTSLaFS---PDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 36-68 8.75e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 55769546     36 FTHHAHTASLSAVAV--NSRFVVTGSKDETIHIYD 68
Cdd:smart00320   6 KTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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