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Conserved domains on  [gi|56466456|gb|EAL44542|]
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lipid phosphate phosphatase, putative [Entamoeba histolytica HM-1:IMSS]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Homo sapiens phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-215 4.31e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 182.80  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  45 VNVLYPYRDS-TFSEAVAGIVIYASTILIIIAFQIK-RLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALV 122
Cdd:cd03390   1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 123 AQGKE--------------------KDAWKSFPSGHSAASFCGYTYLSLYIAGELRIFSDRPELWRMIPVIIPMFLAGII 182
Cdd:cd03390  81 FPDGGtpsdtlvgidicctgdpgvlKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                       170       180       190
                ....*....|....*....|....*....|...
gi 56466456 183 VLTRTRDYYHNFSDVLAGSIIGILSACIGYFSK 215
Cdd:cd03390 161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-215 4.31e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 182.80  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  45 VNVLYPYRDS-TFSEAVAGIVIYASTILIIIAFQIK-RLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALV 122
Cdd:cd03390   1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 123 AQGKE--------------------KDAWKSFPSGHSAASFCGYTYLSLYIAGELRIFSDRPELWRMIPVIIPMFLAGII 182
Cdd:cd03390  81 FPDGGtpsdtlvgidicctgdpgvlKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                       170       180       190
                ....*....|....*....|....*....|...
gi 56466456 183 VLTRTRDYYHNFSDVLAGSIIGILSACIGYFSK 215
Cdd:cd03390 161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02715 PLN02715
lipid phosphate phosphatase
 14-212 1.25e-26

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 105.14  E-value: 1.25e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   14 DIIYIIVTGAVAAVLTFIDGFHMEVpGGENNVNVLYPYRDSTFSeaVAGIVIYAS--TILIIIAFQIKRLSFKHTIFTFI 91
Cdd:PLN02715  50 DWIILVILIAIEIGLNLISPFYRYV-GKDMMTDLKYPFKDNTVP--IWSVPVYAVllPIILFVCFYLKRRCVYDLHHSIL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   92 GLGASVTTWLMFVQGGKIYAGRPRPNMY---------------ALVAQGKE---KDAWKSFPSGHSAASFCGYTYLSLYI 153
Cdd:PLN02715 127 GLLFAVLITGVITDSIKVATGRPRPNFYwrcfpdgkelydalgGVICHGKAaevKEGHKSFPSGHTSWSFAGLTFLSLYL 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 56466456  154 AGELRIFSDRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:PLN02715 207 SGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCY 265
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 93-212 2.28e-18

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 78.23  E-value: 2.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456    93 LGASVTTWLMFVQGGKIYAGRPRPNMYAL-----VAQGKEKDAWKSFPSGHSAASFCGYTYLSLYIAGelrifsdRPELW 167
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLegglvPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR-------LRKIV 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 56466456   168 RMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:pfam01569  75 RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 59-212 2.68e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.99  E-value: 2.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  59 AVAGIVIYASTILIIIAFQIKRLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALVAQGKEKDAWKSFPSGH 138
Cdd:COG0671  44 LLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGH 123

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56466456 139 SAASFCGYTYLSLYiagelrifsdrpeLWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:COG0671 124 AAAAFALALVLALL-------------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
acidPPc smart00014
Acid phosphatase homologues;
108-210 5.26e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 66.22  E-value: 5.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456    108 KIYAGRPRP------NMYALVAQGKEKDAWKSFPSGHSAASFCGYTYLSLYIagelrifsdRPELWRMIPVIIPMFLAGI 181
Cdd:smart00014  15 KNYFGRPRPfflsigDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGRKLLIFLLLLLALV 85

                           90       100
                   ....*....|....*....|....*....
gi 56466456    182 IVLTRTRDYYHNFSDVLAGSIIGILSACI 210
Cdd:smart00014  86 VGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-215 4.31e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 182.80  E-value: 4.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  45 VNVLYPYRDS-TFSEAVAGIVIYASTILIIIAFQIK-RLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALV 122
Cdd:cd03390   1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 123 AQGKE--------------------KDAWKSFPSGHSAASFCGYTYLSLYIAGELRIFSDRPELWRMIPVIIPMFLAGII 182
Cdd:cd03390  81 FPDGGtpsdtlvgidicctgdpgvlKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                       170       180       190
                ....*....|....*....|....*....|...
gi 56466456 183 VLTRTRDYYHNFSDVLAGSIIGILSACIGYFSK 215
Cdd:cd03390 161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02715 PLN02715
lipid phosphate phosphatase
 14-212 1.25e-26

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 105.14  E-value: 1.25e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   14 DIIYIIVTGAVAAVLTFIDGFHMEVpGGENNVNVLYPYRDSTFSeaVAGIVIYAS--TILIIIAFQIKRLSFKHTIFTFI 91
Cdd:PLN02715  50 DWIILVILIAIEIGLNLISPFYRYV-GKDMMTDLKYPFKDNTVP--IWSVPVYAVllPIILFVCFYLKRRCVYDLHHSIL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   92 GLGASVTTWLMFVQGGKIYAGRPRPNMY---------------ALVAQGKE---KDAWKSFPSGHSAASFCGYTYLSLYI 153
Cdd:PLN02715 127 GLLFAVLITGVITDSIKVATGRPRPNFYwrcfpdgkelydalgGVICHGKAaevKEGHKSFPSGHTSWSFAGLTFLSLYL 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 56466456  154 AGELRIFSDRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:PLN02715 207 SGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCY 265
PLN02250 PLN02250
lipid phosphate phosphatase
 14-222 5.22e-25

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 100.39  E-value: 5.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   14 DIIYIIVTGAVAAVLTFIDGFHMEVpGGENNVNVLYPYRDSTFS-EAVAGIVIYASTILIIIAFQIKR--LSFKHTIftf 90
Cdd:PLN02250  25 DWLILLLLVVIEVVLNVIEPFHRFV-GKDMLTDLSYPLQDNTIPfWAVPLIAILLPFAVILVYYFIRRdvYDLHHAI--- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   91 IGLGASVTTWLMFVQGGKIYAGRPRPNMY-----------------ALVAQGKE--KDAWKSFPSGHSAASFCGYTYLSL 151
Cdd:PLN02250 101 LGLLFSVLITGVITDAIKDAVGRPRPDFFwrcfpdgkgvfhpvttdVLCTGAKSviKEGHKSFPSGHTSWSFAGLGFLSL 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56466456  152 YIAGELRIFSDRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGYFSKFESLFSP 222
Cdd:PLN02250 181 YLSGKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPPPYDI 251
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 88-212 6.77e-22

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 87.52  E-value: 6.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  88 FTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALV----AQGKEKDAWKSFPSGHSAASFCGYTYLSLYIagelrifsdR 163
Cdd:cd01610   3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCgpdgDPLLLTEGGYSFPSGHAAFAFALALFLALLL---------P 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 56466456 164 PELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:cd01610  74 RRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 14-216 8.58e-20

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 86.62  E-value: 8.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   14 DIIYIIVTGAVAAVLTFIDGFHMEVpGGENNVNVLYPYRDSTFSeaVAGIVIYAS--TILIIIAFQIKRLSFKHTIFTFI 91
Cdd:PLN02731  44 DWIILVLLVILECVLLIIHPFYRFV-GKDMMTDLSYPLKSNTVP--IWSVPVYAMllPLVIFIFIYFRRRDVYDLHHAVL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456   92 GLGASVTTWLMFVQGGKIYAGRPRPNMY---------------ALVAQGKE---KDAWKSFPSGHSAASFCGYTYLSLYI 153
Cdd:PLN02731 121 GLLYSVLVTAVLTDAIKNAVGRPRPDFFwrcfpdgkalydslgDVICHGDKsviREGHKSFPSGHTSWSFSGLGFLSLYL 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56466456  154 AGELRIFSDRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGYFSKF 216
Cdd:PLN02731 201 SGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFF 263
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 93-212 2.28e-18

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 78.23  E-value: 2.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456    93 LGASVTTWLMFVQGGKIYAGRPRPNMYAL-----VAQGKEKDAWKSFPSGHSAASFCGYTYLSLYIAGelrifsdRPELW 167
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLegglvPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR-------LRKIV 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 56466456   168 RMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:pfam01569  75 RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 83-208 3.39e-16

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 73.05  E-value: 3.39e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  83 FKHTIFTFIGLGAsvtTWLmFVQGGKIYAGRPRP--------NMYALVAQGKE----------------KDAWKSFPSGH 138
Cdd:cd03384   3 YRFVGVFLFGLFA---TQL-LTDLGKYVTGRLRPhfldvckpNYTDLTCSLDHqyiadctcctgdpdliREARLSFPSGH 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56466456 139 SAASFCGYTYLSLYIagELRIFSDRPELwrMIPVIIPMFLA-GIIV-LTRTRDYYHNFSDVLAGSIIGILSA 208
Cdd:cd03384  79 ASLSMYAAVFLALYL--QARLKLRGSRL--LRPLLQFLLLAlALYVgLSRISDYKHHWSDVLAGALLGSVIA 146
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 59-212 2.68e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.99  E-value: 2.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  59 AVAGIVIYASTILIIIAFQIKRLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALVAQGKEKDAWKSFPSGH 138
Cdd:COG0671  44 LLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGH 123

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56466456 139 SAASFCGYTYLSLYiagelrifsdrpeLWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:COG0671 124 AAAAFALALVLALL-------------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
acidPPc smart00014
Acid phosphatase homologues;
108-210 5.26e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 66.22  E-value: 5.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456    108 KIYAGRPRP------NMYALVAQGKEKDAWKSFPSGHSAASFCGYTYLSLYIagelrifsdRPELWRMIPVIIPMFLAGI 181
Cdd:smart00014  15 KNYFGRPRPfflsigDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGRKLLIFLLLLLALV 85

                           90       100
                   ....*....|....*....|....*....
gi 56466456    182 IVLTRTRDYYHNFSDVLAGSIIGILSACI 210
Cdd:smart00014  86 VGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 63-216 4.86e-12

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 62.63  E-value: 4.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  63 IVIYASTILIIIAFQIKRLSFKHTIFTFIGLGASVTTWLMfvqggKIYAGRPRP-NMYALVAQGKekdawkSFPSGHSAA 141
Cdd:cd03392  42 AVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGALNTLL-----KLLVQRPRPpLHLLVPEGGY------SFPSGHAMG 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56466456 142 SFCGYTYLSLYIAGELrifsdRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGI--LSACIGYFSKF 216
Cdd:cd03392 111 ATVLYGFLAYLLARRL-----PRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLawLALLILLYRRL 182
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 93-212 2.13e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 58.88  E-value: 2.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  93 LGASVTTWLMFVQGGKIYAGRPRPNMYAlvaqgkekDAWKSFPSGHSAASFCGYTYLSlyiageLRIFSDRPELWRMIpv 172
Cdd:cd03394   8 LAEAAALTAAVTEGLKFAVGRARPDGSN--------NGYRSFPSGHTASAFAAATFLQ------YRYGWRWYGIPAYA-- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56466456 173 iipmfLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGY 212
Cdd:cd03394  72 -----LASLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 101-208 1.09e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 47.31  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 101 LMFVQGGKIYAGRPRP-----NMYALVAQgkekDAWkSFPSGHSAASFCGYTYL--SLYIAGELRIfsdrpelwrmiPVI 173
Cdd:cd03391  60 IITVAILKALVRRRRPaynspDMLDYVAV----DKY-SFPSGHASRAAFVARFLlnHLVLAVPLRV-----------LLV 123

                        90       100       110
                ....*....|....*....|....*....|....*
gi 56466456 174 IpmfLAGIIVLTRTRDYYHNFSDVLAGSIIGILSA 208
Cdd:cd03391 124 L---WATVVGISRVLLGRHHVLDVLAGAFLGYLEA 155
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 108-213 1.41e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 44.23  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 108 KIYAGRPRP------NMYALVAQGKEkDAWKSFPSGHSAASFCGYTYLSLyiagelrIFsdrPELWrmipviiPMFLAGI 181
Cdd:cd03389  89 KFIIGRARPkllfddGLYGFDPFHAD-YAFTSFPSGHSATAGAAAAALAL-------LF---PRYR-------WAFILLA 150

                        90       100       110
                ....*....|....*....|....*....|....
gi 56466456 182 IVLTRTR--DYYHNFSDVLAGSIIGILSACIGYF 213
Cdd:cd03389 151 LLIAFSRviVGAHYPSDVIAGSLLGAVTALALYQ 184
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 70-213 1.71e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 44.18  E-value: 1.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  70 ILIIIAFQIKRLSFKH--TIFTFIGLGASVTTWLmfvQGG--KIYAGRPRP----NMYALVAQGKEKDAWkSFPSGHSAA 141
Cdd:cd03395  38 IFLLLALFILFRKGPIglLILLLVLLAVGFADQL---ASGflKPLVARLRPcnalDGVRLVVLGDQGGSY-SFASSHAAN 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56466456 142 SFCGYTYLSLyiagelrIFSDRPELWRMIPviipmfLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIGYF 213
Cdd:cd03395 114 SFALALFIWL-------FFRRGLFSPVLLL------WALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 63-212 3.00e-04

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 40.75  E-value: 3.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  63 IVIYASTILIIIAFQIKRLSFKHTIFTFIGLGASVTTWLMFVQGGKIYAGRPRPNMYALVAQGKEKDAW----------- 131
Cdd:cd03396  42 SIALAVLLLALALLFFRRKRLRRRRRALLLLILVIGLGLLVVAILKSHWGRPRPWDLTEFGGDAPYTPLfsgpsngcgkg 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 132 KSFPSGHSAAsfcGYTYLSLYIAgelriFSDRPELWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIGILSACIG 211
Cdd:cd03396 122 CSFPSGHASA---GFALLALYFL-----FRRRRPRLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLIALLL 193


                .
gi 56466456 212 Y 212
Cdd:cd03396 194 Y 194
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 47-206 7.37e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 39.18  E-value: 7.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456  47 VLYPYRDS-TFSEAVAGIVIYASTILIIIAFQIKRLsfKHTIFTFIGLGAS-VTTWLMfvqggKIYAGRPRPNMYALVAQ 124
Cdd:cd03382   6 VLYDPGDLlSFLLAYLSLLPVAILVGYATLILFRRE--LEAIYLFIGLLANeALNYVL-----KRIIKEPRPCSGAYFVR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 125 gkekdAWKSFPSGHSAASFCGYTYLSLYIAGELRIFSDRpeLWRMIPVIIPMFLAGIIVLTRTRDYYHNFSDVLAGSIIG 204
Cdd:cd03382  79 -----SGYGMPSSHSQFMGFFAVYLLLFIYLRLGRLNSL--VSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVG 151


                ..
gi 56466456 205 IL 206
Cdd:cd03382 152 IL 153
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 108-204 3.35e-03

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 37.70  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56466456 108 KIYAGRPRP-NMYALVAQGKEKDAW----KSFPSGHSAAsfcGYTY-LSL-YIAGELrifsdRPELwrmipviipmflag 180
Cdd:cd03397 121 KKYYNRPRPfVLNDEPICTPPDESGlakdGSYPSGHTAA---GYAWaLILaELVPER-----ADEI-------------- 178

                        90       100       110
                ....*....|....*....|....*....|..
gi 56466456 181 iivLTRTRDY--------YHNFSDVLAGSIIG 204
Cdd:cd03397 179 ---LARGSEYgqsrivcgVHWPSDVMGGRIMA 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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