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Conserved domains on  [gi|56605926|ref|NP_001008465|]
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COMM domain-containing protein 5 [Gallus gallus]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 117-226 9.20e-65

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 196.13  E-value: 9.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926 117 ELRIPEDFITDFSSIVFGNRRPVSEGTALMQASRLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDGTAHRFEVPV 196
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 56605926 197 AKFQELRYNVALILKEMNDLEKRSILKIQD 226
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 117-226 9.20e-65

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 196.13  E-value: 9.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926 117 ELRIPEDFITDFSSIVFGNRRPVSEGTALMQASRLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDGTAHRFEVPV 196
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 56605926 197 AKFQELRYNVALILKEMNDLEKRSILKIQD 226
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 150-209 4.20e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.49  E-value: 4.20e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605926   150 RLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDG----TAHRFEVPVAKFQELRYNVALI 209
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 117-226 9.20e-65

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 196.13  E-value: 9.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926 117 ELRIPEDFITDFSSIVFGNRRPVSEGTALMQASRLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDGTAHRFEVPV 196
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 56605926 197 AKFQELRYNVALILKEMNDLEKRSILKIQD 226
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 131-226 2.04e-17

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 74.27  E-value: 2.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926 131 IVFGNRRPVSEGTALMQASrLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDGTAHrfevpvaKFQELRYNVALIL 210
Cdd:cd04748   1 LLTENKAEIEELLSKQSLS-LPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNN-------SSEKICFEMTKEE 72

                        90
                ....*....|....*.
gi 56605926 211 KEmNDLEKRSILKIQD 226
Cdd:cd04748  73 LQ-NFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 150-209 4.20e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.49  E-value: 4.20e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56605926   150 RLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDG----TAHRFEVPVAKFQELRYNVALI 209
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEEA 64
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 94-194 2.30e-04

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 40.37  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926  94 LLREALRLPLSTfkqEVFKEDLKELRIPEDFITDFSSIVFGNRRPVSEGTALMqASRLPNVQDFKWRVDVAISTSSLARA 173
Cdd:cd04750  43 LLIESTKLKLSE---RDFQDSIEFLGFSDDLNEILLQLYESNRKEIRNILKEL-SPDLPHYHNLEWRLDVQIASRSLRSQ 118

                        90       100
                ....*....|....*....|.
gi 56605926 174 LQPSILMLMKLSDGTAHRFEV 194
Cdd:cd04750 119 VKPVITMKLHLEDENKKIETH 139
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 151-186 6.70e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 37.93  E-value: 6.70e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 56605926 151 LPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSD 186
Cdd:cd04757  31 LPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQE 66
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 150-216 2.86e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 37.41  E-value: 2.86e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605926 150 RLPNVQDFKWRVDVAISTSSLARALQPSILMLMKLSDG-----TAHRFEVPVAKFQELRYNVALILKEMNDL 216
Cdd:cd04752 103 RLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNAdtgeiTPHPFSVSADKFRVLLAELKQAQTLMETL 174
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 76-218 9.12e-03

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 35.95  E-value: 9.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605926  76 STDLSEEQLAFLISGMYTLLREALR--LPLSTFKQEVFKEDLKELRIPEDFITDFSSIVFGNRRPVSEgtALMQASRL-P 152
Cdd:cd04749  29 YPEDPLEEFRALHNKMRGLLKSIASadMDINQLEAFLTAQTKKQGGITSLQAAVIAKFWKVHKKKIRE--SLLAQSRWeN 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56605926 153 NVQDFKWRVDVAISTSSLARALQPSILMLMKLSDgTAHRFEVPVAKFQELRynVALILKEMNDLEK 218
Cdd:cd04749 107 SLRGLSWRVDLKTQSRHIAQINSPVAIVELELGK-TGQESEFVCLEFDEAK--VNRVLKQLAEIQE 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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