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Conserved domains on  [gi|568907658|ref|XP_006496543|]
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solute carrier family 23 member 3 isoform X3 [Mus musculus]

Protein Classification

permease family protein( domain architecture ID 581063)

permease family protein, similar to Saccharomyces cerevisiae boron transporter 1 which functions in boric acid/borate export across the plasma membrane thereby protects yeast cells from boron toxicity and is involved in the trafficking of proteins to the vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Xan_ur_permease super family cl23746
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
 247-332 5.95e-23

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


The actual alignment was detected with superfamily member pfam00860:

Pssm-ID: 474042 [Multi-domain]  Cd Length: 389  Bit Score: 100.06  E-value: 5.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658  247 TQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALLL 326
Cdd:pfam00860 304 TKVYSRRVGVTAGVILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGI 383


                  ....*.
gi 568907658  327 PRWLRE 332
Cdd:pfam00860 384 STVPEL 389
 
Name Accession Description Interval E-value
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
 247-332 5.95e-23

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 100.06  E-value: 5.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658  247 TQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALLL 326
Cdd:pfam00860 304 TKVYSRRVGVTAGVILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGI 383


                  ....*.
gi 568907658  327 PRWLRE 332
Cdd:pfam00860 384 STVPEL 389
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
 251-338 1.62e-11

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 65.92  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658 251 SRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALL----- 325
Cdd:COG2233  316 SRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNLLIVAVSLGLGLGvtgvp 395

                         90
                 ....*....|....*...
gi 568907658 326 -----LPRWLReaPVLLN 338
Cdd:COG2233  396 galatLPATLG--PLFLS 411
ncs2 TIGR00801
uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of ...
 247-340 1.67e-08

uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2, localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39). [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273276  Cd Length: 412  Bit Score: 56.53  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658  247 TQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMAL-- 324
Cdd:TIGR00801 302 TRVASRWVIVGAAVILIALGLVPKIAALITSIPSPVLGGAMLVMFGMVAASGIRILSRSKLDFRRNLLIIAASVGLGLgv 381

                          90
                  ....*....|....*..
gi 568907658  325 -LLPRWLREAPVLLNTG 340
Cdd:TIGR00801 382 tGVPDIFGNLPLLLLSG 398
 
Name Accession Description Interval E-value
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
 247-332 5.95e-23

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 100.06  E-value: 5.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658  247 TQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALLL 326
Cdd:pfam00860 304 TKVYSRRVGVTAGVILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGI 383


                  ....*.
gi 568907658  327 PRWLRE 332
Cdd:pfam00860 384 STVPEL 389
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
 251-338 1.62e-11

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 65.92  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658 251 SRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALL----- 325
Cdd:COG2233  316 SRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNLLIVAVSLGLGLGvtgvp 395

                         90
                 ....*....|....*...
gi 568907658 326 -----LPRWLReaPVLLN 338
Cdd:COG2233  396 galatLPATLG--PLFLS 411
ncs2 TIGR00801
uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of ...
 247-340 1.67e-08

uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2, localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39). [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273276  Cd Length: 412  Bit Score: 56.53  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568907658  247 TQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMAL-- 324
Cdd:TIGR00801 302 TRVASRWVIVGAAVILIALGLVPKIAALITSIPSPVLGGAMLVMFGMVAASGIRILSRSKLDFRRNLLIIAASVGLGLgv 381

                          90
                  ....*....|....*..
gi 568907658  325 -LLPRWLREAPVLLNTG 340
Cdd:TIGR00801 382 tGVPDIFGNLPLLLLSG 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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