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Conserved domains on  [gi|568915307|ref|XP_006498754|]
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dipeptidyl peptidase 4 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
102-472 6.23e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 379.74  E-value: 6.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  102 SPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRqliTEEKIPNN---TQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHR 178
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETN---RVEPLPPGegkIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  179 ITSTGeENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQyPKTVWIPYPKAGAVNP 258
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  259 TVKFFIVNIDslssssSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCpseqq 338
Cdd:pfam00930 156 TVELFVYDLA------SGKTVEVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL----- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  339 hvEMSTTGWVgrFRPAEPHFTS-DGSSFYKiISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEA--LTSDYLYYISNq 415
Cdd:pfam00930 225 --EETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT- 298
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568915307  416 yKEMPGGRNLYKIQLTDHTNVKCLSCDLNPErcqYYAVSFSKEAKYYQLGCWGPGLP 472
Cdd:pfam00930 299 -EDSPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 super family cl47529
Prolyl oligopeptidase family;
553-680 2.04e-39

Prolyl oligopeptidase family;


The actual alignment was detected with superfamily member pfam00326:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 144.29  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  553 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSM 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568915307  633 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPIPEDNLDHYRVF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYL 132
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
36-56 3.00e-05

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


:

Pssm-ID: 465875  Cd Length: 21  Bit Score: 40.93  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|.
gi 568915307   36 DSRRTYSLADYLKSTFRVKSY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
102-472 6.23e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 379.74  E-value: 6.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  102 SPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRqliTEEKIPNN---TQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHR 178
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETN---RVEPLPPGegkIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  179 ITSTGeENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQyPKTVWIPYPKAGAVNP 258
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  259 TVKFFIVNIDslssssSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCpseqq 338
Cdd:pfam00930 156 TVELFVYDLA------SGKTVEVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL----- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  339 hvEMSTTGWVgrFRPAEPHFTS-DGSSFYKiISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEA--LTSDYLYYISNq 415
Cdd:pfam00930 225 --EETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT- 298
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568915307  416 yKEMPGGRNLYKIQLTDHTNVKCLSCDLNPErcqYYAVSFSKEAKYYQLGCWGPGLP 472
Cdd:pfam00930 299 -EDSPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
553-680 2.04e-39

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 144.29  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  553 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSM 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568915307  633 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPIPEDNLDHYRVF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYL 132
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
516-678 4.55e-31

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 121.66  E-value: 4.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 516 TRFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDASFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTL 595
Cdd:COG1506    8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 596 EVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGLpiPED 672
Cdd:COG1506   73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGG--PWE 150

                 ....*.
gi 568915307 673 NLDHYR 678
Cdd:COG1506  151 DPEAYA 156
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
36-56 3.00e-05

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 40.93  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|.
gi 568915307   36 DSRRTYSLADYLKSTFRVKSY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
102-472 6.23e-127

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 379.74  E-value: 6.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  102 SPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRqliTEEKIPNN---TQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHR 178
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETN---RVEPLPPGegkIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  179 ITSTGeENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQyPKTVWIPYPKAGAVNP 258
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGPG-PEVREIKYPKAGAPNP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  259 TVKFFIVNIDslssssSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCpseqq 338
Cdd:pfam00930 156 TVELFVYDLA------SGKTVEVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL----- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  339 hvEMSTTGWVgrFRPAEPHFTS-DGSSFYKiISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEA--LTSDYLYYISNq 415
Cdd:pfam00930 225 --EETSDGWV--ELHQDPHFIKrDGSGFLW-ISERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGvdETRDLVYFTAT- 298
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568915307  416 yKEMPGGRNLYKIQLTDHTNVKCLSCDLNPErcqYYAVSFSKEAKYYQLGCWGPGLP 472
Cdd:pfam00930 299 -EDSPTERHLYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
553-680 2.04e-39

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 144.29  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307  553 FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSM 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568915307  633 VLGSGSGVFKCGIAVAPVSRWEYYDS----VYTERYMGLPIPEDNLDHYRVF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDYL 132
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
516-678 4.55e-31

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 121.66  E-value: 4.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 516 TRFWYQMILPPhfdKSKKYPLLLDVYAGPCSQkaDASFRLnWATYLAStENIIVASFDGRGSGYQGdkimhainRRLGTL 595
Cdd:COG1506    8 TTLPGWLYLPA---DGKKYPVVVYVHGGPGSR--DDSFLP-LAQALAS-RGYAVLAPDYRGYGESA--------GDWGGD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 596 EVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSV---YTERYMGLpiPED 672
Cdd:COG1506   73 EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGG--PWE 150

                 ....*.
gi 568915307 673 NLDHYR 678
Cdd:COG1506  151 DPEAYA 156
DPPIV_rep pfam18811
Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an ...
36-56 3.00e-05

Dipeptidyl peptidase IV (DPP IV) low complexity region; Dipeptidyl peptidase IV includes an helical N-terminal region, the pfam00930 domain and the pfam00326 domain, comprising the active site. This Pfam entry represents a sequence that can be repeated in the low complexity region between the helical N-terminus and the DPPIV_N domain.


Pssm-ID: 465875  Cd Length: 21  Bit Score: 40.93  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|.
gi 568915307   36 DSRRTYSLADYLKSTFRVKSY 56
Cdd:pfam18811   1 DSRRTFTLEDYLNNTFRYKSY 21
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
560-650 7.84e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 44.57  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 560 YLAstenIIVASFDGRGSGYQGDKIMHAINRrLGTLEVEDQIEAARQFVK-MGFVDSKRVAIWGWSYGGYVTsMVLGSGS 638
Cdd:COG0412   57 YVV----LAPDLYGRGGPGDDPDEARALMGA-LDPELLAADLRAALDWLKaQPEVDAGRVGVVGFCFGGGLA-LLAAARG 130
                         90
                 ....*....|..
gi 568915307 639 GVFKCGIAVAPV 650
Cdd:COG0412  131 PDLAAAVSFYGG 142
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
519-670 2.25e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 43.36  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 519 WYqmiLPPhfDKSKKYPLLldVYAGPCSqkADASFRLNWATYLAStENIIVASFDGRGSGY-QGDKimhainRRLGTLEV 597
Cdd:COG1073   27 LY---LPA--GASKKYPAV--VVAHGNG--GVKEQRALYAQRLAE-LGFNVLAFDYRGYGEsEGEP------REEGSPER 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915307 598 EDqIEAARQFVK-MGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVfKCGIAVAPvsrweyYDSV------YTERYMGLPIP 670
Cdd:COG1073   91 RD-ARAAVDYLRtLPGVDPERIGLLGISLGGGYALNAAATDPRV-KAVILDSP------FTSLedlaaqRAKEARGAYLP 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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