|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
650-794 |
3.44e-39 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 141.69 E-value: 3.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 650 CYDAFVSYSEQDshWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 729
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922750 730 SHFRLFDENNDAAILVLLEPIErKAIPQRFCKLRKIMnTKTYLEWPLDEgqQEVFWVNLRTAIKS 794
Cdd:smart00255 79 ALENALEEGGLRVIPIFYEVIP-SDVRKQPGKFRKVF-KKNYLKWPEDE--KEQFWKKALYAVPS 139
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
651-775 |
2.33e-18 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 83.18 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 651 YDAFVSYSEQDS-HWVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 729
Cdd:pfam01582 1 YDVFLSFRGSDTrEWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568922750 730 S-HFRLfdENNDAAILVLLEPIE---RKAI---PQRFCKLRKIMNTKTYLEWP 775
Cdd:pfam01582 79 IlECAL--DLGQKVIPIFYEVDPsdvRKQTgsfGKAFKKHKKVLTEEKVLKWR 129
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
345-565 |
1.32e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 86.14 E-value: 1.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 345 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsackgaWPSLQTLVLSQNHLRSMqktGEILLTL 422
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 423 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 498
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568922750 499 LKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQIL 565
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-305 |
1.85e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.21 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 53 FTSIPSGLT--AAMKSLDLSFNKITYIGHgDLRACANLQVLMLKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwF 130
Cdd:COG4886 148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-L 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 131 GPLSSLKYLNLMGNPYQTLgvtSLFPNLTNLQTLRIGN--VETFSEIrridfAGLTSLNELEIKALSLRNYQSQSLKSIR 208
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNnqLTDLPPL-----ANLTNLKTLDLSNNQLTDLKLKELELLL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 209 DIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE 288
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
|
250
....*....|....*..
gi 568922750 289 LSEVEFDDCTLNGLGDF 305
Cdd:COG4886 377 ATLLTLALLLLTLLLLL 393
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
87-145 |
3.89e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.47 E-value: 3.89e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 568922750 87 NLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNP 145
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
350-568 |
2.38e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 64.33 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 350 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSackgawpsLQTLVLSQNHLRSMQKT-----GEILLTLKN 424
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 425 LT-----------SLDISRNTFHPMPDSCqwPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 492
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 493 YISRNKLKTLPdASLFPVLLVMKIRENAVSTF-------------SKDQLGSFPK-----LETLEAGDNHFVCSCELL-S 553
Cdd:PRK15370 331 EAGENALTSLP-ASLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409
|
250
....*....|....*
gi 568922750 554 FTMETPALAQILVDW 568
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-238 |
3.56e-08 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 54.79 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 67 LDLSFNKITYIGhgDLRACANLQVLMLKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNpy 146
Cdd:cd21340 7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 147 qTLGVTSLFPNLTNLQTLRIGNVETFSEIR-RIDFAGLTSL-NELEIkaLSLRNYQSQSLKSIRDIHHL-TLHLSESAFL 223
Cdd:cd21340 79 -RISVVEGLENLTNLEELHIENQRLPPGEKlTFDPRSLAALsNSLRV--LNISGNNIDSLEPLAPLRNLeQLDASNNQIS 155
|
170
....*....|....*.
gi 568922750 224 -LEIFADILSSVRYLE 238
Cdd:cd21340 156 dLEELLDLLSSWPSLR 171
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
85-564 |
1.99e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 48.31 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 85 CANLQVLMLKSSRINTIE----------GDAFYSLGSLEHLDLSDNHLS-SLSSSWFGPLSSLKYLNLMGNPYqtlgvTS 153
Cdd:PLN00113 58 CLWQGITCNNSSRVVSIDlsgknisgkiSSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF-----TG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 154 LFPN--LTNLQTLRIGN----------VETFSEIRRIDFAG----------LTSLNELEIKALSLRNYQSQSLKSIRDIH 211
Cdd:PLN00113 133 SIPRgsIPNLETLDLSNnmlsgeipndIGSFSSLKVLDLGGnvlvgkipnsLTNLTSLEFLTLASNQLVGQIPRELGQMK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 212 HLT-LHLSESAFLLEIFADI--LSSVRYLELRDTNLArfqfSPLPVDEVS-SPMKKLAFRGSVLTDESFNELLKLLRYIl 287
Cdd:PLN00113 213 SLKwIYLGYNNLSGEIPYEIggLTSLNHLDLVYNNLT----GPIPSSLGNlKNLQYLFLYQNKLSGPIPPSIFSLQKLI- 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 288 elsEVEFDDCTLNGlgdfnpsesDVVSELGKVETVTIrrLHipqfyLFydlstvysllekvkritvENSKVFLVPCSFSQ 367
Cdd:PLN00113 288 ---SLDLSDNSLSG---------EIPELVIQLQNLEI--LH-----LF------------------SNNFTGKIPVALTS 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 368 hLKSLEFLDLSENLMVEEYLKNSackGAWPSLQTLVLSQNHLrsmqkTGEILLTL---KNLTSLDISRNTFH-PMPDS-- 441
Cdd:PLN00113 331 -LPRLQVLQLWSNKFSGEIPKNL---GKHNNLTVLDLSTNNL-----TGEIPEGLcssGNLFKLILFSNSLEgEIPKSlg 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 442 -CQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNL----DSFSLFLPRLQELYISRNK-LKTLPDAS--------- 506
Cdd:PLN00113 402 aCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFgskrlenld 481
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568922750 507 ---------------LFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFvcSCELLSFTMETPALAQI 564
Cdd:PLN00113 482 lsrnqfsgavprklgSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL--SGQIPASFSEMPVLSQL 552
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
397-538 |
4.71e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 397 PSLQTLVLSQNHLRSMqktgEILLTLKNLTSLDISRNTFHPmpdscqwPEKMRFLNLSSTGIRvvktcipQTLEVLDVSN 476
Cdd:cd21340 68 VNLKKLYLGGNRISVV----EGLENLTNLEELHIENQRLPP-------GEKLTFDPRSLAALS-------NSLRVLNISG 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568922750 477 NNLDSFSLF--LPRLQELYISRNKLKTLPDA----SLFPVLLVMKIRENAVSTFSK--DQL-GSFPKLETL 538
Cdd:cd21340 130 NNIDSLEPLapLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVL 200
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
487-545 |
1.08e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.08e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568922750 487 PRLQELYISRNKLKTLPDASLF--PVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHF 545
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
543-596 |
1.67e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.72 E-value: 1.67e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568922750 543 NHFVCSCELLSFTMEtpALAQILVDWPDSYLCDSPPRLHGhRLQDARPSVLECH 596
Cdd:smart00082 1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
59-435 |
1.84e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.22 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 59 GLTAAMKSLDLSFNKITyiGH--GDLRACANLQVLMLKSSRI---------------------NTIEGDAFYSLG---SL 112
Cdd:PLN00113 161 GSFSSLKVLDLGGNVLV--GKipNSLTNLTSLEFLTLASNQLvgqiprelgqmkslkwiylgyNNLSGEIPYEIGgltSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 113 EHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFpNLTNLQTLRIGNVETFSEIRRI-------------- 178
Cdd:PLN00113 239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELviqlqnleilhlfs 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 179 -DFAG-----LTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLEIFADILSSVRYLELrdtnlarFQFSP 251
Cdd:PLN00113 318 nNFTGkipvaLTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTvLDLSTNNLTGEIPEGLCSSGNLFKL-------ILFSN 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 252 LPVDEVSSPMKKL-AFRGSVLTDESFNEllKLLRYILELSEVEFDDCTLNGLgdfnpsesdvvseLGKVETvtiRRLHIP 330
Cdd:PLN00113 391 SLEGEIPKSLGACrSLRRVRLQDNSFSG--ELPSEFTKLPLVYFLDISNNNL-------------QGRINS---RKWDMP 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 331 QFYLFyDLStvysllekvkritvENSKVFLVPCSFSQhlKSLEFLDLSENL---MVEEYLknsackGAWPSLQTLVLSQN 407
Cdd:PLN00113 453 SLQML-SLA--------------RNKFFGGLPDSFGS--KRLENLDLSRNQfsgAVPRKL------GSLSELMQLKLSEN 509
|
410 420 430
....*....|....*....|....*....|.
gi 568922750 408 HLrsmqkTGEI---LLTLKNLTSLDISRNTF 435
Cdd:PLN00113 510 KL-----SGEIpdeLSSCKKLVSLDLSHNQL 535
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
650-794 |
3.44e-39 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 141.69 E-value: 3.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 650 CYDAFVSYSEQDshWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 729
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922750 730 SHFRLFDENNDAAILVLLEPIErKAIPQRFCKLRKIMnTKTYLEWPLDEgqQEVFWVNLRTAIKS 794
Cdd:smart00255 79 ALENALEEGGLRVIPIFYEVIP-SDVRKQPGKFRKVF-KKNYLKWPEDE--KEQFWKKALYAVPS 139
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
651-775 |
2.33e-18 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 83.18 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 651 YDAFVSYSEQDS-HWVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 729
Cdd:pfam01582 1 YDVFLSFRGSDTrEWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568922750 730 S-HFRLfdENNDAAILVLLEPIE---RKAI---PQRFCKLRKIMNTKTYLEWP 775
Cdd:pfam01582 79 IlECAL--DLGQKVIPIFYEVDPsdvRKQTgsfGKAFKKHKKVLTEEKVLKWR 129
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
345-565 |
1.32e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 86.14 E-value: 1.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 345 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsackgaWPSLQTLVLSQNHLRSMqktGEILLTL 422
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 423 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 498
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568922750 499 LKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQIL 565
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-305 |
1.85e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.21 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 53 FTSIPSGLT--AAMKSLDLSFNKITYIGHgDLRACANLQVLMLKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwF 130
Cdd:COG4886 148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-L 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 131 GPLSSLKYLNLMGNPYQTLgvtSLFPNLTNLQTLRIGN--VETFSEIrridfAGLTSLNELEIKALSLRNYQSQSLKSIR 208
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNnqLTDLPPL-----ANLTNLKTLDLSNNQLTDLKLKELELLL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 209 DIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE 288
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
|
250
....*....|....*..
gi 568922750 289 LSEVEFDDCTLNGLGDF 305
Cdd:COG4886 377 ATLLTLALLLLTLLLLL 393
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
654-728 |
1.38e-14 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 70.81 E-value: 1.38e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922750 654 FVSYSEQDSHWVENLmVQQLENSDppFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELD 728
Cdd:pfam13676 2 FISYAGEDRAWAEWL-ADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
62-310 |
7.70e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.20 E-value: 7.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 62 AAMKSLDLSFNKITYIGHgDLRACANLQVLMLKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwFGPLSSLKYLNL 141
Cdd:COG4886 113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 142 MGNPYQTLGVTslFPNLTNLQTLRIGNvetfSEIRRI--DFAGLTSLNEleikaLSLRNYQSQSLKSIRDIHHLT-LHLS 218
Cdd:COG4886 190 SNNQITDLPEP--LGNLTNLEELDLSG----NQLTDLpePLANLTNLET-----LDLSNNQLTDLPELGNLTNLEeLDLS 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 219 ESAflleiFADI-----LSSVRYLELRDTNLARFQFSPLPVD-EVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEV 292
Cdd:COG4886 259 NNQ-----LTDLpplanLTNLKTLDLSNNQLTDLKLKELELLlGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
|
250
....*....|....*...
gi 568922750 293 EFDDCTLNGLGDFNPSES 310
Cdd:COG4886 334 LVTLTTLALSLSLLALLT 351
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
87-145 |
3.89e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.47 E-value: 3.89e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 568922750 87 NLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNP 145
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
277-555 |
2.13e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 69.96 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 277 NELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIpqfylfYDLSTVYSLLEKVKRITVENS 356
Cdd:COG4886 73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQL------TDLPEELANLTNLKELDLSNN 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 357 KVFLVPCSFSQhLKSLEFLDLSENLMVEeyLKNSAckGAWPSLQTLVLSQNHLRSMQKTgeiLLTLKNLTSLDISRNTFH 436
Cdd:COG4886 147 QLTDLPEPLGN-LTNLKSLDLSNNQLTD--LPEEL--GNLTNLKELDLSNNQITDLPEP---LGNLTNLEELDLSGNQLT 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 437 PMPDSCQWPEKMRFLNLSSTGIrvvkTCIPQ-----TLEVLDVSNNNLDSF--SLFLPRLQELYISRNKLKTLPDASLFP 509
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNNQL----TDLPElgnltNLEELDLSNNQLTDLppLANLTNLKTLDLSNNQLTDLKLKELEL 294
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568922750 510 VLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFT 555
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
65-283 |
5.12e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.34 E-value: 5.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 65 KSLDLSFNKityighgDLRACANLQVLMLKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwFGPLSSLKYLNLMGN 144
Cdd:COG4886 99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 145 PYQTLGvtSLFPNLTNLQTLRIGN--VETFSEirriDFAGLTSLNEleikaLSLRNYQSQSL-KSIRDIHHLT-LHLSES 220
Cdd:COG4886 170 QLTDLP--EELGNLTNLKELDLSNnqITDLPE----PLGNLTNLEE-----LDLSGNQLTDLpEPLANLTNLEtLDLSNN 238
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922750 221 AflLEIFADI--LSSVRYLELRDTNLARfqfspLPVDEVSSPMKKLAFRGSVLTDESFNELLKLL 283
Cdd:COG4886 239 Q--LTDLPELgnLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLL 296
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
350-568 |
2.38e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 64.33 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 350 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSackgawpsLQTLVLSQNHLRSMQKT-----GEILLTLKN 424
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 425 LT-----------SLDISRNTFHPMPDSCqwPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 492
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 493 YISRNKLKTLPdASLFPVLLVMKIRENAVSTF-------------SKDQLGSFPK-----LETLEAGDNHFVCSCELL-S 553
Cdd:PRK15370 331 EAGENALTSLP-ASLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409
|
250
....*....|....*
gi 568922750 554 FTMETPALAQILVDW 568
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
65-122 |
4.17e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 4.17e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 568922750 65 KSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHL 122
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-238 |
3.56e-08 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 54.79 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 67 LDLSFNKITYIGhgDLRACANLQVLMLKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNpy 146
Cdd:cd21340 7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 147 qTLGVTSLFPNLTNLQTLRIGNVETFSEIR-RIDFAGLTSL-NELEIkaLSLRNYQSQSLKSIRDIHHL-TLHLSESAFL 223
Cdd:cd21340 79 -RISVVEGLENLTNLEELHIENQRLPPGEKlTFDPRSLAALsNSLRV--LNISGNNIDSLEPLAPLRNLeQLDASNNQIS 155
|
170
....*....|....*.
gi 568922750 224 -LEIFADILSSVRYLE 238
Cdd:cd21340 156 dLEELLDLLSSWPSLR 171
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
72-391 |
2.11e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.17 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 72 NKITYIGHGDLRACANLQVLMLKSSrintiegDAFYSLGSLEHLDLSDNHLSSLSSSwFGPLSSLKYLNLMGNPYQTLGv 151
Cdd:COG4886 82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP- 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 152 tSLFPNLTNLQTLRIGNvetfSEIRRID--FAGLTSLNEleikaLSLRNYQSQSL-KSIRDIHHLT-LHLSESAfLLEIF 227
Cdd:COG4886 153 -EPLGNLTNLKSLDLSN----NQLTDLPeeLGNLTNLKE-----LDLSNNQITDLpEPLGNLTNLEeLDLSGNQ-LTDLP 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 228 ADI--LSSVRYLELRDTNLarfqfSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYiLELSEVEFDDCTLNGLGDF 305
Cdd:COG4886 222 EPLanLTNLETLDLSNNQL-----TDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT-LDLSNNQLTDLKLKELELL 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 306 NPSESDVVSELGKVETVTIRRLH--IPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMV 383
Cdd:COG4886 296 LGLNSLLLLLLLLNLLELLILLLllTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
|
....*...
gi 568922750 384 EEYLKNSA 391
Cdd:COG4886 376 EATLLTLA 383
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-245 |
9.32e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.78 E-value: 9.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 53 FTSIPSGLTA--AMKSLDLSFNKITYIGhgDLRACANLQVLMLKSSRINTIegDAFYSLGSLEHLDLSDNHLSSLSSSWF 130
Cdd:COG4886 217 LTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKEL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 131 GPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEirrIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDI 210
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT---LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
|
170 180 190
....*....|....*....|....*....|....*
gi 568922750 211 HHLTLHLSESAFLLEIFADILSSVRYLELRDTNLA 245
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
82-145 |
1.10e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.09 E-value: 1.10e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568922750 82 LRACAN-LQVLMLKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLS--SSWFGPLSSLKYLNLMGNP 145
Cdd:cd21340 115 LAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNP 179
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
85-564 |
1.99e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 48.31 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 85 CANLQVLMLKSSRINTIE----------GDAFYSLGSLEHLDLSDNHLS-SLSSSWFGPLSSLKYLNLMGNPYqtlgvTS 153
Cdd:PLN00113 58 CLWQGITCNNSSRVVSIDlsgknisgkiSSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF-----TG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 154 LFPN--LTNLQTLRIGN----------VETFSEIRRIDFAG----------LTSLNELEIKALSLRNYQSQSLKSIRDIH 211
Cdd:PLN00113 133 SIPRgsIPNLETLDLSNnmlsgeipndIGSFSSLKVLDLGGnvlvgkipnsLTNLTSLEFLTLASNQLVGQIPRELGQMK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 212 HLT-LHLSESAFLLEIFADI--LSSVRYLELRDTNLArfqfSPLPVDEVS-SPMKKLAFRGSVLTDESFNELLKLLRYIl 287
Cdd:PLN00113 213 SLKwIYLGYNNLSGEIPYEIggLTSLNHLDLVYNNLT----GPIPSSLGNlKNLQYLFLYQNKLSGPIPPSIFSLQKLI- 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 288 elsEVEFDDCTLNGlgdfnpsesDVVSELGKVETVTIrrLHipqfyLFydlstvysllekvkritvENSKVFLVPCSFSQ 367
Cdd:PLN00113 288 ---SLDLSDNSLSG---------EIPELVIQLQNLEI--LH-----LF------------------SNNFTGKIPVALTS 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 368 hLKSLEFLDLSENLMVEEYLKNSackGAWPSLQTLVLSQNHLrsmqkTGEILLTL---KNLTSLDISRNTFH-PMPDS-- 441
Cdd:PLN00113 331 -LPRLQVLQLWSNKFSGEIPKNL---GKHNNLTVLDLSTNNL-----TGEIPEGLcssGNLFKLILFSNSLEgEIPKSlg 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 442 -CQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNL----DSFSLFLPRLQELYISRNK-LKTLPDAS--------- 506
Cdd:PLN00113 402 aCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFgskrlenld 481
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568922750 507 ---------------LFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFvcSCELLSFTMETPALAQI 564
Cdd:PLN00113 482 lsrnqfsgavprklgSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL--SGQIPASFSEMPVLSQL 552
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
397-538 |
4.71e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 397 PSLQTLVLSQNHLRSMqktgEILLTLKNLTSLDISRNTFHPmpdscqwPEKMRFLNLSSTGIRvvktcipQTLEVLDVSN 476
Cdd:cd21340 68 VNLKKLYLGGNRISVV----EGLENLTNLEELHIENQRLPP-------GEKLTFDPRSLAALS-------NSLRVLNISG 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568922750 477 NNLDSFSLF--LPRLQELYISRNKLKTLPDA----SLFPVLLVMKIRENAVSTFSK--DQL-GSFPKLETL 538
Cdd:cd21340 130 NNIDSLEPLapLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVL 200
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
487-545 |
1.08e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.08e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568922750 487 PRLQELYISRNKLKTLPDASLF--PVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHF 545
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
451-545 |
1.57e-04 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 45.15 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 451 LNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPdaSLFPVLLVMKIRENAVSTFSK---- 526
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP--VLPPGLLELSIFSNPLTHLPAlpsg 283
|
90 100 110
....*....|....*....|....*....|.
gi 568922750 527 --------DQLGSF----PKLETLEAGDNHF 545
Cdd:PRK15387 284 lcklwifgNQLTSLpvlpPGLQELSVSDNQL 314
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
543-596 |
1.67e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.72 E-value: 1.67e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 568922750 543 NHFVCSCELLSFTMEtpALAQILVDWPDSYLCDSPPRLHGhRLQDARPSVLECH 596
Cdd:smart00082 1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
59-435 |
1.84e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.22 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 59 GLTAAMKSLDLSFNKITyiGH--GDLRACANLQVLMLKSSRI---------------------NTIEGDAFYSLG---SL 112
Cdd:PLN00113 161 GSFSSLKVLDLGGNVLV--GKipNSLTNLTSLEFLTLASNQLvgqiprelgqmkslkwiylgyNNLSGEIPYEIGgltSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 113 EHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFpNLTNLQTLRIGNVETFSEIRRI-------------- 178
Cdd:PLN00113 239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELviqlqnleilhlfs 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 179 -DFAG-----LTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLEIFADILSSVRYLELrdtnlarFQFSP 251
Cdd:PLN00113 318 nNFTGkipvaLTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTvLDLSTNNLTGEIPEGLCSSGNLFKL-------ILFSN 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 252 LPVDEVSSPMKKL-AFRGSVLTDESFNEllKLLRYILELSEVEFDDCTLNGLgdfnpsesdvvseLGKVETvtiRRLHIP 330
Cdd:PLN00113 391 SLEGEIPKSLGACrSLRRVRLQDNSFSG--ELPSEFTKLPLVYFLDISNNNL-------------QGRINS---RKWDMP 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 331 QFYLFyDLStvysllekvkritvENSKVFLVPCSFSQhlKSLEFLDLSENL---MVEEYLknsackGAWPSLQTLVLSQN 407
Cdd:PLN00113 453 SLQML-SLA--------------RNKFFGGLPDSFGS--KRLENLDLSRNQfsgAVPRKL------GSLSELMQLKLSEN 509
|
410 420 430
....*....|....*....|....*....|.
gi 568922750 408 HLrsmqkTGEI---LLTLKNLTSLDISRNTF 435
Cdd:PLN00113 510 KL-----SGEIpdeLSSCKKLVSLDLSHNQL 535
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
372-543 |
5.59e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 372 LEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFL 451
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 452 NLSSTGIRVVKTCIPQTLEVLDVSNNNLDSfslFLPRLQELYISRNKLKTLPDA-SLFPVLLVMKIRENAVSTFSKDqLG 530
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS---NLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLPEP-LG 156
|
170
....*....|...
gi 568922750 531 SFPKLETLEAGDN 543
Cdd:COG4886 157 NLTNLKSLDLSNN 169
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
424-499 |
7.23e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 424 NLTSLDISRNTFHPMPDSCqwpekmrFLNLSStgirvvktcipqtLEVLDVSNNNLDSFSL----FLPRLQELYISRNKL 499
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGA-------FKGLSN-------------LKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
81-144 |
1.73e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 41.73 E-value: 1.73e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568922750 81 DLRACANLQVLMLKSsriNTIEGDAFYSLG---SLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGN 144
Cdd:PLN03150 437 DISKLRHLQSINLSG---NSIRGNIPPSLGsitSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
65-161 |
3.06e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.42 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 65 KSLDLSFNK-----ITYIGHGdLRACANLQVLMLKSSRINTIEG----DAFYSLGSLEHLDLSDNHLSS-----LSSSWF 130
Cdd:cd00116 168 KELNLANNGigdagIRALAEG-LKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALL 246
|
90 100 110
....*....|....*....|....*....|....*..
gi 568922750 131 GPLSSLKYLNLMGNPYQTLGVTSL------FPNLTNL 161
Cdd:cd00116 247 SPNISLLTLSLSCNDITDDGAKDLaevlaeKESLLEL 283
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
111-145 |
3.19e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 3.19e-03
10 20 30
....*....|....*....|....*....|....*
gi 568922750 111 SLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNP 145
Cdd:pfam12799 2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNN 34
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
362-433 |
3.79e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.77 E-value: 3.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568922750 362 PCSFSQHLKSLEFLDLSENLMVE----EYLKNsackgawpsLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRN 433
Cdd:cd21340 112 PRSLAALSNSLRVLNISGNNIDSleplAPLRN---------LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
261-513 |
8.99e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 38.88 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 261 MKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRR--LHIPQFYLFYDL 338
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDnaLGPDGCGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 339 STVYSLLE-KVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMveeylkNSACKGAW-------PSLQTLVLSQNHLR 410
Cdd:cd00116 105 LRSSSLQElKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRL------EGASCEALakalranRDLKELNLANNGIG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922750 411 S------------------------------MQKTGEILLTLKNLTSLDISRNtfhpmpdscqwpekmrflNLSSTGIRV 460
Cdd:cd00116 179 DagiralaeglkancnlevldlnnngltdegASALAETLASLKSLEVLNLGDN------------------NLTDAGAAA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922750 461 VKTCIP---QTLEVLDVSNNNLD-----SFSLFL---PRLQELYISRNKLKTLPDASLFPVLLV 513
Cdd:cd00116 241 LASALLspnISLLTLSLSCNDITddgakDLAEVLaekESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
467-504 |
8.99e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.91 E-value: 8.99e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568922750 467 QTLEVLDVSNNNLDSFSLF--LPRLQELYISRN-KLKTLPD 504
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPPLakLPNLETLDLSGNnKITDLSD 41
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
397-458 |
9.45e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.19 E-value: 9.45e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922750 397 PSLQTLVLSQNHLRSMQKtgEILLTLKNLTSLDISRN---TFHpmPDSCQWPEKMRFLNLSSTGI 458
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNlltTLS--PGAFSGLPSLRYLDLSGNRL 61
|
|
| |
