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Conserved domains on  [gi|568926925|ref|XP_006538097|]
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FK506-binding protein 15 isoform X1 [Mus musculus]

Protein Classification

FKBP_C and Smc domain-containing protein( domain architecture ID 13624727)

protein containing domains FKBP_C, Smc, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
192-285 3.31e-28

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 109.21  E-value: 3.31e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   192 AVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVIGW 271
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 568926925   272 TQPTDSILVFEVEV 285
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 561-885 8.67e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 8.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNS------LQTATENTQARILHAEQ 634
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELeerleeLEEELAELEEELEELEE 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  635 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRR 714
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  715 QLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERcQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTL 794
Cdd:COG1196   418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE-EEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  795 AQAELQSqweakcEQLLASARDEHLQQyrevcAQRDAHQQKLALLQD--------ECLALQAQIAAFTEQKEHMQRLEKT 866
Cdd:COG1196   497 LEAEADY------EGFLEGVKAALLLA-----GLRGLAGAVAVLIGVeaayeaalEAALAAALQNIVVEDDEVAAAAIEY 565

                         330
                  ....*....|....*....
gi 568926925  867 KSQAPAGRAAADPSEKVKK 885
Cdd:COG1196   566 LKAAKAGRATFLPLDKIRA 584
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 944-1129 1.16e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  944 PLRPSLEQPGPATPGMPPAPPSGETQEAPEvlpeqvvgettPLPLQALPTPENGAQTrkgePAEAEVPSEIKDSSLPPQP 1023
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAPTTDPAGA-----------GEPSGAVPQPWLGALV----PGRVAVPRFRVPQPAPSRE 2987

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925 1024 AGIPA-HRVLGPPTSIPPKPPGPVTMDSESEEMLAADQRTVQPNgllgeEHVREVATDGLLQGNSRRLSL-TPDPEKGEP 1101
Cdd:PHA03247 2988 APASStPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPP-----DDTEDSDADSLFDSDSERSDLeALDPLPPEP 3062

                         170       180
                  ....*....|....*....|....*....
gi 568926925 1102 PalDPESQGGEAQPPECKQAEDVSSS-GP 1129
Cdd:PHA03247 3063 H--DPFAHEPDPATPEAGARESPSSQfGP 3089
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 302-497 2.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   302 SSRDSAAPSPIPASDSLSADPVVTPLPLPLKPGEPGLRsksnslseqlTVNSNPDTVKAKLISRMAKMgQPMLPILPPQl 381
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT----------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPS- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   382 dSNDSETEDATVLRGAGQSLVTP-SIQPSLQPaHPVLPQMASQAPQPSGSglQTPSAAlmqavsldshsavsgnaqnfQP 460
Cdd:pfam03154  260 -QVSPQPLPQPSLHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVPPGP--------------------SP 315

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 568926925   461 YAGVQAYAYPQTPSVTSQLQP-----VRPLYPAPLSQaPHFQ 497
Cdd:pfam03154  316 AAPGQSQQRIHTPPSQSQLQSqqpprEQPLPPAPLSM-PHIK 356
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
192-285 3.31e-28

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 109.21  E-value: 3.31e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   192 AVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVIGW 271
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 568926925   272 TQPTDSILVFEVEV 285
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 183-285 3.33e-26

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 103.72  E-value: 3.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  183 QDLVAAEGPAVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACA 262
Cdd:COG0545     4 KVLKEGTGAKPKAGDTVTVHYTGTLLD----GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....*.
gi 568926925  263 ---AGSEGVIgwtqPTDSILVFEVEV 285
Cdd:COG0545    80 ygeRGAGGVI----PPNSTLVFEVEL 101
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 561-885 8.67e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 8.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNS------LQTATENTQARILHAEQ 634
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELeerleeLEEELAELEEELEELEE 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  635 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRR 714
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  715 QLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERcQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTL 794
Cdd:COG1196   418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE-EEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  795 AQAELQSqweakcEQLLASARDEHLQQyrevcAQRDAHQQKLALLQD--------ECLALQAQIAAFTEQKEHMQRLEKT 866
Cdd:COG1196   497 LEAEADY------EGFLEGVKAALLLA-----GLRGLAGAVAVLIGVeaayeaalEAALAAALQNIVVEDDEVAAAAIEY 565

                         330
                  ....*....|....*....
gi 568926925  867 KSQAPAGRAAADPSEKVKK 885
Cdd:COG1196   566 LKAAKAGRATFLPLDKIRA 584
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 573-841 9.71e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.80  E-value: 9.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   573 ERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLM------MEKRNNSLQTATENTQARILHAEQEKAKVTEELAAA 646
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQELEEKLEELrlevseLEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   647 TAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEE 726
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   727 LTDLRAEKTSLEKNLS---ERKKKSAQERCQAEAEMDEIRKS-HQEELDRLRQLLKKArVSTDQAAAEQLTLAQAELqsq 802
Cdd:TIGR02168  395 IASLNNEIERLEARLErleDRRERLQQEIEELLKKLEEAELKeLQAELEELEEELEEL-QEELERLEEALEELREEL--- 470

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 568926925   803 weAKCEQLLASARDEHLQqyrevcaqrdaHQQKLALLQD 841
Cdd:TIGR02168  471 --EEAEQALDAAERELAQ-----------LQARLDSLER 496
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
563-898 9.22e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.16  E-value: 9.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  563 SNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTA---TENTQARILHAEQEKAKV 639
Cdd:PRK03918  324 NGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTgltPEKLEKELEELEKAKEEI 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  640 TEELAAATAQVSHL------------QLK------------MTAHQKKE-------------------TELQLQLTDNLK 676
Cdd:PRK03918  404 EEEISKITARIGELkkeikelkkaieELKkakgkcpvcgreLTEEHRKElleeytaelkriekelkeiEEKERKLRKELR 483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  677 ETDLLRGHVTRLQA------------------DLSELREASEQTQT-------------KFKSEKQSRRQLELKVTSLEE 725
Cdd:PRK03918  484 ELEKVLKKESELIKlkelaeqlkeleeklkkyNLEELEKKAEEYEKlkekliklkgeikSLKKELEKLEELKKKLAELEK 563

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  726 ELTDLRAEKTSLEKNLSERKKKSAQErcqAEAEMDEIRKSHQE---------ELDRLRQLLKKARVSTDQAAAEqLTLAQ 796
Cdd:PRK03918  564 KLDELEEELAELLKELEELGFESVEE---LEERLKELEPFYNEylelkdaekELEREEKELKKLEEELDKAFEE-LAETE 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  797 AELQSQwEAKCEQLLASARDEhlqQYREVcaqrdahQQKLALLQDECLALQAQIAAFTEQKEHMQR-LEKTKSQAPAGRA 875
Cdd:PRK03918  640 KRLEEL-RKELEELEKKYSEE---EYEEL-------REEYLELSRELAGLRAELEELEKRREEIKKtLEKLKEELEEREK 708

                         410       420
                  ....*....|....*....|...
gi 568926925  876 AADPSEKVKKIMNQVfQSLRGEF 898
Cdd:PRK03918  709 AKKELEKLEKALERV-EELREKV 730
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 566-829 1.67e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 62.06  E-value: 1.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   566 QRIIQENERLKQELlEKSSRIEEQNDKISDLIERNQR-YVEQSNLMMEkRNNSLQTATENTQARilhaEQEKAKvTEELA 644
Cdd:pfam17380  299 ERLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQAAiYAEQERMAME-RERELERIRQEERKR----ELERIR-QEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   645 AATAQVSHLQ-LKMTAHQKK----------------ETELQLQLTDNLKETDLLRGHVTRL-QADLSELREASEQTQTKF 706
Cdd:pfam17380  372 MEISRMRELErLQMERQQKNervrqeleaarkvkilEEERQRKIQQQKVEMEQIRAEQEEArQREVRRLEEERAREMERV 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   707 KSEKQSRRQlelKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEElDRLRQLLKKARVSTDQ 786
Cdd:pfam17380  452 RLEEQERQQ---QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEE-ERKRKLLEKEMEERQK 527

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 568926925   787 AAAEQLTLAQAELQSQWEAKCEQllasaRDEHLQQYREVCAQR 829
Cdd:pfam17380  528 AIYEEERRREAEEERRKQQEMEE-----RRRIQEQMRKATEER 565
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 190-308 3.03e-08

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 56.31  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  190 GPAVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSgkVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVI 269
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTLID----GKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568926925  270 GWtqPTDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAA 308
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268
growth_prot_Scy NF041483
polarized growth protein Scy;
571-821 6.16e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.51  E-value: 6.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  571 ENERLKQELLEKSSRIEEQNDkisDLIERNQRYVEQSNLMMEKRNNSLQTATENTqARILHAEQEKAkVTEELAAATAQV 650
Cdd:NF041483  503 ESERVRTEAIERATTLRRQAE---ETLERTRAEAERLRAEAEEQAEEVRAAAERA-ARELREETERA-IAARQAEAAEEL 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  651 SHLQlkmTAHQKKETELQLQLTDNLKETDLLRghvtrlqadlselREASEQTQtKFKSEKQSR-RQLElkvTSLEEELTD 729
Cdd:NF041483  578 TRLH---TEAEERLTAAEEALADARAEAERIR-------------REAAEETE-RLRTEAAERiRTLQ---AQAEQEAER 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  730 LRAEKTS-LEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQwEAKCE 808
Cdd:NF041483  638 LRTEAAAdASAARAEGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQEEAARR-RREAE 716

                         250
                  ....*....|...
gi 568926925  809 QLLASARDEHLQQ 821
Cdd:NF041483  717 ETLGSARAEADQE 729
PHA03247 PHA03247
large tegument protein UL36; Provisional
 944-1129 1.16e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  944 PLRPSLEQPGPATPGMPPAPPSGETQEAPEvlpeqvvgettPLPLQALPTPENGAQTrkgePAEAEVPSEIKDSSLPPQP 1023
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAPTTDPAGA-----------GEPSGAVPQPWLGALV----PGRVAVPRFRVPQPAPSRE 2987

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925 1024 AGIPA-HRVLGPPTSIPPKPPGPVTMDSESEEMLAADQRTVQPNgllgeEHVREVATDGLLQGNSRRLSL-TPDPEKGEP 1101
Cdd:PHA03247 2988 APASStPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPP-----DDTEDSDADSLFDSDSERSDLeALDPLPPEP 3062

                         170       180
                  ....*....|....*....|....*....
gi 568926925 1102 PalDPESQGGEAQPPECKQAEDVSSS-GP 1129
Cdd:PHA03247 3063 H--DPFAHEPDPATPEAGARESPSSQfGP 3089
tig TIGR00115
trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first ...
 185-255 1.22e-04

trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY). The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity. This protein is found in a single copy in virtually every bacterial genome. [Protein fate, Protein folding and stabilization]


Pssm-ID: 272913 [Multi-domain]  Cd Length: 410  Bit Score: 46.01  E-value: 1.22e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926925   185 LVAAEGPAVETGDSLEVAYTGwllqnHVLGQVFDSTANKDkpLRLKLGSGKVVKGLEDGLLGMKKGGKRLI 255
Cdd:TIGR00115  141 LVPVERGAAEKGDRVTIDFEG-----FIDGEAFEGGKAEN--FSLELGSGQFIPGFEEQLVGMKAGEEKEI 204
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 561-999 8.04e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.85  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQEnerlKQELLEKSSRIEEQ--NDKISDLierNQRYVEQSNLMMEKRNNSLQTAT-ENTQARILHAEQEKA 637
Cdd:NF033838   63 VESHLEKILSE----IQKSLDKRKHTQNValNKKLSDI---KTEYLYELNVLKEKSEAELTSKTkKELDAAFEQFKKDTL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  638 KVTEELAAATAQVSHLQLKmtAHQKKETELQLQLTDNLK--ETDLLRGHVTRLQADLSELREASEQTQtkfksEKQSRRQ 715
Cdd:NF033838  136 EPGKKVAEATKKVEEAEKK--AKDQKEEDRRNYPTNTYKtlELEIAESDVEVKKAELELVKEEAKEPR-----DEEKIKQ 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  716 LELKVTSLEEELTDLRAEKTSLEKnlSERKKKSAQERCQAEAEMDEIRKSHQE------------ELDRLRQLLKKARvS 783
Cdd:NF033838  209 AKAKVESKKAEATRLEKIKTDREK--AEEEAKRRADAKLKEAVEKNVATSEQDkpkrrakrgvlgEPATPDKKENDAK-S 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  784 TDQAAAEQlTLAQAELqsqweaKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAqiaAFTEQKEHMQRL 863
Cdd:NF033838  286 SDSSVGEE-TLPSPSL------KPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYPTNTYKTLELEI---AESDVKVKEAEL 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  864 EKTKSQAPAGRAaadpSEKVKKIMNQVfQSLRGEfeleesydgGTILRTIMHTIKmvtlqllnhqEEEEEEEEEEEEEKK 943
Cdd:NF033838  356 ELVKEEAKEPRN----EEKIKQAKAKV-ESKKAE---------ATRLEKIKTDRK----------KAEEEAKRKAAEEDK 411

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925  944 PLRPSLEQPGPATPGMP--PAP--------PSGE---TQEAPEVLPEQVVGETTPLPLQALPTPENGAQ 999
Cdd:NF033838  412 VKEKPAEQPQPAPAPQPekPAPkpekpaeqPKAEkpaDQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQ 480
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 302-497 2.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   302 SSRDSAAPSPIPASDSLSADPVVTPLPLPLKPGEPGLRsksnslseqlTVNSNPDTVKAKLISRMAKMgQPMLPILPPQl 381
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT----------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPS- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   382 dSNDSETEDATVLRGAGQSLVTP-SIQPSLQPaHPVLPQMASQAPQPSGSglQTPSAAlmqavsldshsavsgnaqnfQP 460
Cdd:pfam03154  260 -QVSPQPLPQPSLHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVPPGP--------------------SP 315

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 568926925   461 YAGVQAYAYPQTPSVTSQLQP-----VRPLYPAPLSQaPHFQ 497
Cdd:pfam03154  316 AAPGQSQQRIHTPPSQSQLQSqqpprEQPLPPAPLSM-PHIK 356
growth_prot_Scy NF041483
polarized growth protein Scy;
566-884 4.70e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  566 QRIIQEN----ERLKQELLEKSSRIEEQNDKisDLIERNQ---RYVEQSNLMMEKrnnsLQTATEnTQARILhAEQEKAK 638
Cdd:NF041483  104 QRILQEHaehqARLQAELHTEAVQRRQQLDQ--ELAERRQtveSHVNENVAWAEQ----LRARTE-SQARRL-LDESRAE 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVShlQLKMTAHQKKETELQLQLTDnlKETDLLRGHVTR---LQADLSELREAS---EQTQTKFKSE-KQ 711
Cdd:NF041483  176 AEQALAAARAEAE--RLAEEARQRLGSEAESARAE--AEAILRRARKDAerlLNAASTQAQEATdhaEQLRSSTAAEsDQ 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  712 SRRQL-------ELKVTSLEEELTDLRAEKtslEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVST 784
Cdd:NF041483  252 ARRQAaelsraaEQRMQEAEEALREARAEA---EKVVAEAKEAAAKQLASAESANEQRTRTAKEEIARLVGEATKEAEAL 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  785 dQAAAEQLtLAQAelqsqwEAKCEQLLASARDehlqQYREVCAQRDAHQ-QKLALLQDECLA-----LQAQIAAFTEQKE 858
Cdd:NF041483  329 -KAEAEQA-LADA------RAEAEKLVAEAAE----KARTVAAEDTAAQlAKAARTAEEVLTkasedAKATTRAAAEEAE 396

                         330       340
                  ....*....|....*....|....*....
gi 568926925  859 HMQRlektKSQAPAGR---AAADPSEKVK 884
Cdd:NF041483  397 RIRR----EAEAEADRlrgEAADQAEQLK 421
PHA03247 PHA03247
large tegument protein UL36; Provisional
 302-495 7.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  302 SSRDSAAPSPIPASDSLSADPVVTPLPLPLKPGEPGlrskSNSLSEQLTVNSNPDTVKAKLISRMAKMGQPMLPILPPQ- 380
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP----PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  381 ----------------LDSNDSETEDATVLRGAGQSLVTPSIQPSLQPAHPVLPqmASQAPQPSGSGLQTPSAALMQAvs 444
Cdd:PHA03247 2683 prrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPARPA-- 2758

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  445 ldSHSAVSGNAQNFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPH 495
Cdd:PHA03247 2759 --RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP 2807
growth_prot_Scy NF041483
polarized growth protein Scy;
672-831 7.48e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 40.58  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  672 TDNLKETDLLRGHVTRLQADL-SELREASEQTQTKFKSEKQSRR-----QLELKVTSLEEELTDLRAEK----TSLEKNL 741
Cdd:NF041483  909 SDAAAQADRLIGEATSEAERLtAEARAEAERLRDEARAEAERVRadaaaQAEQLIAEATGEAERLRAEAaetvGSAQQHA 988

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  742 SERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTlaqaELQSQWEAKCEQLLASARDEHLQQ 821
Cdd:NF041483  989 ERIRTEAERVKAEAAAEAERLRTEAREEADRTLDEARKDANKRRSEAAEQAD----TLITEAAAEADQLTAKAQEEALRT 1064

                         170
                  ....*....|
gi 568926925  822 YREVCAQRDA 831
Cdd:NF041483 1065 TTEAEAQADT 1074
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
192-285 3.31e-28

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 109.21  E-value: 3.31e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   192 AVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVIGW 271
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 568926925   272 TQPTDSILVFEVEV 285
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 183-285 3.33e-26

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 103.72  E-value: 3.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  183 QDLVAAEGPAVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACA 262
Cdd:COG0545     4 KVLKEGTGAKPKAGDTVTVHYTGTLLD----GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....*.
gi 568926925  263 ---AGSEGVIgwtqPTDSILVFEVEV 285
Cdd:COG0545    80 ygeRGAGGVI----PPNSTLVFEVEL 101
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 561-885 8.67e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 8.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNS------LQTATENTQARILHAEQ 634
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELeerleeLEEELAELEEELEELEE 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  635 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRR 714
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  715 QLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERcQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTL 794
Cdd:COG1196   418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE-EEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  795 AQAELQSqweakcEQLLASARDEHLQQyrevcAQRDAHQQKLALLQD--------ECLALQAQIAAFTEQKEHMQRLEKT 866
Cdd:COG1196   497 LEAEADY------EGFLEGVKAALLLA-----GLRGLAGAVAVLIGVeaayeaalEAALAAALQNIVVEDDEVAAAAIEY 565

                         330
                  ....*....|....*....
gi 568926925  867 KSQAPAGRAAADPSEKVKK 885
Cdd:COG1196   566 LKAAKAGRATFLPLDKIRA 584
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 601-892 1.69e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 91.92  E-value: 1.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  601 QRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDL 680
Cdd:COG1196   213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  681 LRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKK---SAQERCQAEA 757
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAElaeAEEALLEAEA 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  758 EMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQsqwEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLA 837
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER---LERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  838 LLQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAADPSEKVKKIMNQVFQ 892
Cdd:COG1196   450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 573-841 9.71e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.80  E-value: 9.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   573 ERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLM------MEKRNNSLQTATENTQARILHAEQEKAKVTEELAAA 646
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQELEEKLEELrlevseLEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   647 TAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEE 726
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   727 LTDLRAEKTSLEKNLS---ERKKKSAQERCQAEAEMDEIRKS-HQEELDRLRQLLKKArVSTDQAAAEQLTLAQAELqsq 802
Cdd:TIGR02168  395 IASLNNEIERLEARLErleDRRERLQQEIEELLKKLEEAELKeLQAELEELEEELEEL-QEELERLEEALEELREEL--- 470

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 568926925   803 weAKCEQLLASARDEHLQqyrevcaqrdaHQQKLALLQD 841
Cdd:TIGR02168  471 --EEAEQALDAAERELAQ-----------LQARLDSLER 496
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 531-857 1.19e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.42  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   531 LMTKVEELQKHSSgnsMLLPSMSV-TMETSMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNL 609
Cdd:TIGR02169  693 LQSELRRIENRLD---ELSQELSDaSRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   610 MMEKRNNsLQTATENTQARILHA-----EQEKAKVTEELAAATAQVSHLQLKMtahqkKETELQLQLTDNLKETdlLRGH 684
Cdd:TIGR02169  770 LEEDLHK-LEEALNDLEARLSHSripeiQAELSKLEEEVSRIEARLREIEQKL-----NRLTLEKEYLEKEIQE--LQEQ 841

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   685 VTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKsaqeRCQAEAEMDEIRK 764
Cdd:TIGR02169  842 RIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERK----IEELEAQIEKKRK 917

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   765 sHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQ-SQWEAKCEQLLASARD------EHLQQYREVCAQRDAHQQKLA 837
Cdd:TIGR02169  918 -RLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSlEDVQAELQRVEEEIRAlepvnmLAIQEYEEVLKRLDELKEKRA 996

                          330       340
                   ....*....|....*....|
gi 568926925   838 LLQDECLALQAQIAAFTEQK 857
Cdd:TIGR02169  997 KLEEERKAILERIEEYEKKK 1016
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 565-821 2.00e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 78.44  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  565 IQRIIQENERLKQELLEKSSRIEEQNDKIsDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELA 644
Cdd:COG1196   234 LRELEAELEELEAELEELEAELEELEAEL-AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  645 AATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLE 724
Cdd:COG1196   313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  725 EELTDLRAEKTSLEKNLSERKKKSAQERcQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQWE 804
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLERLE-EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471

                         250
                  ....*....|....*..
gi 568926925  805 AKCEQLLASARDEHLQQ 821
Cdd:COG1196   472 AALLEAALAELLEELAE 488
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 621-902 1.56e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 1.56e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   621 ATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASE 700
Cdd:TIGR02168  664 GSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   701 QTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKK--SAQERCQA-EAEMDEIRKSHQEELDRLRQLL 777
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQieQLKEELKAlREALDELRAELTLLNEEAANLR 823

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   778 KKARVSTDQAAAEQLTLaqAELQSQWEAKCEQL---------LASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQA 848
Cdd:TIGR02168  824 ERLESLERRIAATERRL--EDLEEQIEELSEDIeslaaeieeLEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925   849 QIAaftEQKEHMQRLEKTKSQAPAGRAAADPS-EKVKKIMNQVFQSLRGEFELEE 902
Cdd:TIGR02168  902 ELR---ELESKRSELRRELEELREKLAQLELRlEGLEVRIDNLQERLSEEYSLTL 953
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
624-831 4.97e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 74.18  E-value: 4.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  624 NTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQ--LQLTDNLKETDLLRGHVTRLQADLSELREASeq 701
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAEREIAELEAELERLDASS-- 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  702 tqTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELD-RLRQLLKKA 780
Cdd:COG4913   685 --DDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEeRFAAALGDA 762

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  781 RVstdQAAAEQLTLAQAELQSQwEAKCEQLLASARDEHLQQYREVCAQRDA 831
Cdd:COG4913   763 VE---RELRENLEERIDALRAR-LNRAEEELERAMRAFNREWPAETADLDA 809
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 507-778 2.82e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.63  E-value: 2.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   507 MTEARQHNTEIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSvtMETSMIMSNIQRIIQENERLKQELLEKSSRI 586
Cdd:TIGR02168  686 IEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALR--KDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   587 EEQNDKISDL----------IERNQRYVEQSNLMMEK------------------------RNNSLQTATENTQARILHA 632
Cdd:TIGR02168  764 EELEERLEEAeeelaeaeaeIEELEAQIEQLKEELKAlrealdelraeltllneeaanlreRLESLERRIAATERRLEDL 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   633 EQEKAKVTEELAAATAQVSHLQLKMTahqkketELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQS 712
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEELEELIE-------ELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRE 916

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925   713 RRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLK 778
Cdd:TIGR02168  917 LEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 627-905 3.18e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.24  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   627 ARILHAE-QEKAKVTEELAAataqVSHLQLKmtahqKKETELQL--------QLTDNLKEtdlLRGHVTRLQA------- 690
Cdd:TIGR02168  147 SEIIEAKpEERRAIFEEAAG----ISKYKER-----RKETERKLertrenldRLEDILNE---LERQLKSLERqaekaer 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   691 ------------------DLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKK----- 747
Cdd:TIGR02168  215 ykelkaelrelelallvlRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKElyala 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   748 SAQERCQAEAEMDEIRKSH----QEELDRLRQLLKKARVsTDQAAAEQLTLAQAELQSQWEAKCEQL--LASARDEHLQQ 821
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANlerqLEELEAQLEELESKLD-ELAEELAELEEKLEELKEELESLEAELeeLEAELEELESR 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   822 YREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQ-RLEKTKSQAPAGRAAADPSEKvKKIMNQVFQSLRGEFEL 900
Cdd:TIGR02168  374 LEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdRRERLQQEIEELLKKLEEAEL-KELQAELEELEEELEEL 452


                   ....*
gi 568926925   901 EESYD 905
Cdd:TIGR02168  453 QEELE 457
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
566-865 5.09e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 70.18  E-value: 5.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  566 QRIIQENERLK------QELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKV 639
Cdd:COG4717   139 AELAELPERLEeleerlEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEA 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  640 TEELAAATAQVSHLQLKMTAHQKKETELQLQ--------------LTDNLKETDLLRGHVTRLQA-----DLSELREASE 700
Cdd:COG4717   219 QEELEELEEELEQLENELEAAALEERLKEARlllliaaallallgLGGSLLSLILTIAGVLFLVLgllalLFLLLAREKA 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  701 QTQTKFKSEKQSRRQLELKVTSLEEELTDLRAeKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEE--LDRLRQLLK 778
Cdd:COG4717   299 SLGKEAEELQALPALEELEEEELEELLAALGL-PPDLSPEELLELLDRIEELQELLREAEELEEELQLEelEQEIAALLA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  779 KARVSTD-------------QAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLA 845
Cdd:COG4717   378 EAGVEDEeelraaleqaeeyQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAE 457

                         330       340
                  ....*....|....*....|
gi 568926925  846 LQAQIAAFTEQKEHMQRLEK 865
Cdd:COG4717   458 LEAELEQLEEDGELAELLQE 477
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 659-885 3.57e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 66.71  E-value: 3.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  659 AHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLE 738
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  739 KNLSERKKK------SAQERCQAEAEMDEIRKSHQEELDRLRQLLKKArVSTDQAAAEQLTLAQAELQSQWEAKCEQL-- 810
Cdd:COG4942    97 AELEAQKEElaellrALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYL-APARREQAEELRADLAELAALRAELEAERae 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  811 LASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAADPSEKVKK 885
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 566-798 9.07e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.63  E-value: 9.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   566 QRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQtateNTQARILHAEQEKAKVTEELAA 645
Cdd:TIGR02169  272 QLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLA----KLEAEIDKLLAEIEELEREIEE 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   646 ATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEE 725
Cdd:TIGR02169  348 ERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNA 427

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925   726 ELTDLRAEKTSLE---KNLSERKKKSAQERCQAEAEMDEIRKSH---QEELDRLRQLLKKARVSTDQAAAEQLTLAQAE 798
Cdd:TIGR02169  428 AIAGIEAKINELEeekEDKALEIKKQEWKLEQLAADLSKYEQELydlKEEYDRVEKELSKLQRELAEAEAQARASEERV 506
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
561-825 1.27e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.09  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLK--QELLEKssrIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAK 638
Cdd:COG4913   223 TFEAADALVEHFDDLEraHEALED---AREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEE 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNlkETDLLrghvTRLQADLSELREASEQTQTKFKSEKQSRRQLEL 718
Cdd:COG4913   300 LRAELARLEAELERLEARLDALREELDELEAQIRGN--GGDRL----EQLEREIERLERELEERERRRARLEALLAALGL 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  719 KVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQE---ELDRLRQL-------LKKARvstdQAA 788
Cdd:COG4913   374 PLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELREleaEIASLERRksniparLLALR----DAL 449

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  789 AEQLTLAQAEL------------QSQWEAKCEQLLASAR------DEHLQQYREV 825
Cdd:COG4913   450 AEALGLDEAELpfvgelievrpeEERWRGAIERVLGGFAltllvpPEHYAAALRW 504
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 515-739 3.33e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.69  E-value: 3.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   515 TEIRMAVNKVADKMDHLMTKVEELQKhssgnsmllpsmsvtmETSMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKIS 594
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALAN----------------EISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   595 DLIERNQRYVEQSNL--------------------MMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQ 654
Cdd:TIGR02168  334 ELAEELAELEEKLEElkeelesleaeleeleaeleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLE 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   655 lkmtAHQKKETELQLQLTDNLKETDL--LRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRA 732
Cdd:TIGR02168  414 ----DRRERLQQEIEELLKKLEEAELkeLQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA 489


                   ....*..
gi 568926925   733 EKTSLEK 739
Cdd:TIGR02168  490 RLDSLER 496
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
563-898 9.22e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.16  E-value: 9.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  563 SNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTA---TENTQARILHAEQEKAKV 639
Cdd:PRK03918  324 NGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTgltPEKLEKELEELEKAKEEI 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  640 TEELAAATAQVSHL------------QLK------------MTAHQKKE-------------------TELQLQLTDNLK 676
Cdd:PRK03918  404 EEEISKITARIGELkkeikelkkaieELKkakgkcpvcgreLTEEHRKElleeytaelkriekelkeiEEKERKLRKELR 483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  677 ETDLLRGHVTRLQA------------------DLSELREASEQTQT-------------KFKSEKQSRRQLELKVTSLEE 725
Cdd:PRK03918  484 ELEKVLKKESELIKlkelaeqlkeleeklkkyNLEELEKKAEEYEKlkekliklkgeikSLKKELEKLEELKKKLAELEK 563

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  726 ELTDLRAEKTSLEKNLSERKKKSAQErcqAEAEMDEIRKSHQE---------ELDRLRQLLKKARVSTDQAAAEqLTLAQ 796
Cdd:PRK03918  564 KLDELEEELAELLKELEELGFESVEE---LEERLKELEPFYNEylelkdaekELEREEKELKKLEEELDKAFEE-LAETE 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  797 AELQSQwEAKCEQLLASARDEhlqQYREVcaqrdahQQKLALLQDECLALQAQIAAFTEQKEHMQR-LEKTKSQAPAGRA 875
Cdd:PRK03918  640 KRLEEL-RKELEELEKKYSEE---EYEEL-------REEYLELSRELAGLRAELEELEKRREEIKKtLEKLKEELEEREK 708

                         410       420
                  ....*....|....*....|...
gi 568926925  876 AADPSEKVKKIMNQVfQSLRGEF 898
Cdd:PRK03918  709 AKKELEKLEKALERV-EELREKV 730
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
563-808 1.59e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  563 SNIQRIIQENErlkQELLEKSSRIEEQNDKISDLIERnqryVEqsnlMMEKRNNSLqtatENTQARILHAEQEKAKVTEE 642
Cdd:PRK03918  189 ENIEELIKEKE---KELEEVLREINEISSELPELREE----LE----KLEKEVKEL----EELKEEIEELEKELESLEGS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  643 LAAATAQVSHLQlKMTAHQKKETElqlQLTDNLKETDLLRGHVTRLQAdLSELREaseqtqtKFKSEKqsrRQLELKVTS 722
Cdd:PRK03918  254 KRKLEEKIRELE-ERIEELKKEIE---ELEEKVKELKELKEKAEEYIK-LSEFYE-------EYLDEL---REIEKRLSR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  723 LEEELTDLRAEKTSLEKnLSERKKKSAQERCQAEAEMDEIRKSHqEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQ 802
Cdd:PRK03918  319 LEEEINGIEERIKELEE-KEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGLTPEKLEKELEEL 396


                  ....*.
gi 568926925  803 WEAKCE 808
Cdd:PRK03918  397 EKAKEE 402
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
670-877 1.66e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.09  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  670 QLTDNLKETDLLRGHVTRLQADLSELREASEQtqtkfksekqsrrqlelkvtsLEEELTDLRAEKTSLEKNLseRKKKSA 749
Cdd:COG4717    75 ELEEELKEAEEKEEEYAELQEELEELEEELEE---------------------LEAELEELREELEKLEKLL--QLLPLY 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  750 QERCQAEAEMDEIrkshQEELDRLRQllKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDE---HLQQYREVC 826
Cdd:COG4717   132 QELEALEAELAEL----PERLEELEE--RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElqdLAEELEELQ 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  827 AQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAA 877
Cdd:COG4717   206 QRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAA 256
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 566-829 1.67e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 62.06  E-value: 1.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   566 QRIIQENERLKQELlEKSSRIEEQNDKISDLIERNQR-YVEQSNLMMEkRNNSLQTATENTQARilhaEQEKAKvTEELA 644
Cdd:pfam17380  299 ERLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQAAiYAEQERMAME-RERELERIRQEERKR----ELERIR-QEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   645 AATAQVSHLQ-LKMTAHQKK----------------ETELQLQLTDNLKETDLLRGHVTRL-QADLSELREASEQTQTKF 706
Cdd:pfam17380  372 MEISRMRELErLQMERQQKNervrqeleaarkvkilEEERQRKIQQQKVEMEQIRAEQEEArQREVRRLEEERAREMERV 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   707 KSEKQSRRQlelKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEElDRLRQLLKKARVSTDQ 786
Cdd:pfam17380  452 RLEEQERQQ---QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEE-ERKRKLLEKEMEERQK 527

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 568926925   787 AAAEQLTLAQAELQSQWEAKCEQllasaRDEHLQQYREVCAQR 829
Cdd:pfam17380  528 AIYEEERRREAEEERRKQQEMEE-----RRRIQEQMRKATEER 565
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 567-905 2.11e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 62.11  E-value: 2.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   567 RIIQENERLKQELLEKSSRIEEQNDK--------------ISDLIERNQRYvEQSNLMMEK-------RNNSLQTATENT 625
Cdd:pfam01576  149 KLSKERKLLEERISEFTSNLAEEEEKakslsklknkheamISDLEERLKKE-EKGRQELEKakrklegESTDLQEQIAEL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   626 QARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTD---NLKETDLLRGHVTRLQADLSE----LREA 698
Cdd:pfam01576  228 QAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISElqeDLESERAARNKAEKQRRDLGEeleaLKTE 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   699 SEQTQ--TKFKSEKQSRRQLEL---------------------------KVTSLEEELTDLRAEKTSLEKN--------- 740
Cdd:pfam01576  308 LEDTLdtTAAQQELRSKREQEVtelkkaleeetrsheaqlqemrqkhtqALEELTEQLEQAKRNKANLEKAkqalesena 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   741 --------LSERKKKSAQERCQAEAEMDEIRKSHQEElDRLRQLLkkarvstdqaaAEQLTLAQAELQS------QWEAK 806
Cdd:pfam01576  388 elqaelrtLQQAKQDSEHKRKKLEGQLQELQARLSES-ERQRAEL-----------AEKLSKLQSELESvssllnEAEGK 455

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   807 CEQLL--ASARDEHLQQYREVCAQRDahQQKLAL------LQDECLALQAQIAAFTEQKEHMQR--------LEKTKSQA 870
Cdd:pfam01576  456 NIKLSkdVSSLESQLQDTQELLQEET--RQKLNLstrlrqLEDERNSLQEQLEEEEEAKRNVERqlstlqaqLSDMKKKL 533

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 568926925   871 PAGRAAADPSEKVKKIMNQVFQSLRGEF-ELEESYD 905
Cdd:pfam01576  534 EEDAGTLEALEEGKKRLQRELEALTQQLeEKAAAYD 569
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 569-864 2.35e-09

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 60.70  E-value: 2.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   569 IQENERLKQELLEKSSRIEEqndkisdliernqryveqsnlMMEKRNnslqtatENTQARILHAEQEKAKVTEELAAAta 648
Cdd:pfam13868   28 IAEKKRIKAEEKEEERRLDE---------------------MMEEER-------ERALEEEEEKEEERKEERKRYRQE-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   649 qvshLQLKMTAHQKKETELQLQLtdnLKETDLLRGHVTRLQA-DLSELRE-ASEQTQT-----KFKSEKQSRRQLELKvt 721
Cdd:pfam13868   78 ----LEEQIEEREQKRQEEYEEK---LQEREQMDEIVERIQEeDQAEAEEkLEKQRQLreeidEFNEEQAEWKELEKE-- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   722 slEEELTDLRAEKTSLEKNLSERKKksaqercqaEAEMDEIRKSHQEELDRLRQLLKKARVstDQAAAEQL--TLAQAEL 799
Cdd:pfam13868  149 --EEREEDERILEYLKEKAEREEER---------EAEREEIEEEKEREIARLRAQQEKAQD--EKAERDELraKLYQEEQ 215

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925   800 QSQWEAK----------CEQLLASARDEHL---QQYREVCAQRDAHQQKLALLQdecLALQAQIAAFTEQKEHMQRLE 864
Cdd:pfam13868  216 ERKERQKereeaekkarQRQELQQAREEQIelkERRLAEEAEREEEEFERMLRK---QAEDEEIEQEEAEKRRMKRLE 290
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 562-803 2.71e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  562 MSNIQRIIQENERLKQELLEKssrIEEQNDKISDLIERNQRYVEQSNLmMEKRNNSLQTATENTQARIlhaEQEKAKVTE 641
Cdd:COG4942    36 IAELEKELAALKKEEKALLKQ---LAALERRIAALARRIRALEQELAA-LEAELAELEKEIAELRAEL---EAQKEELAE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  642 ELAAATAQVSHLQLKMTAHQKketelqlQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKfksekqsRRQLELKVT 721
Cdd:COG4942   109 LLRALYRLGRQPPLALLLSPE-------DFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL-------RAELEAERA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  722 SLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEElDRLRQLLKKARVSTDQAAAEQLTLAQAELQS 801
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA-EELEALIARLEAEAAAAAERTPAAGFAALKG 253


                  ..
gi 568926925  802 QW 803
Cdd:COG4942   254 KL 255
PTZ00121 PTZ00121
MAEBL; Provisional
 571-884 3.43e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  571 ENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKvTEELAAATAQV 650
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKK-ADAAKKKAEEK 1390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  651 shlqlKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEqtqTKFKSEkQSRRQLELKVTSlEEELTDL 730
Cdd:PTZ00121 1391 -----KKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE---AKKKAE-EAKKADEAKKKA-EEAKKAE 1460

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  731 RAEKTSLEKNLSERKKKSAQERCQAE--AEMDEIRKSHQEELDRLRQLLKKA---RVSTDQAAAEQLTLAQAELQSQWEA 805
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADeaKKKAEEAKKKADEAKKAAEAKKKAdeaKKAEEAKKADEAKKAEEAKKADEAK 1540

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  806 KCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQK--EHMQRLEKTKSQAPAGRAAADPSEKV 883
Cdd:PTZ00121 1541 KAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAriEEVMKLYEEEKKMKAEEAKKAEEAKI 1620


                  .
gi 568926925  884 K 884
Cdd:PTZ00121 1621 K 1621
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 518-869 7.53e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 60.37  E-value: 7.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   518 RMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSM--IMSNIQRIIQENERLKQELLEKSSRIEEQNDKisd 595
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKqvLEKELKHLREALQQTQQSHAYLTQKREAQEEQ--- 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   596 liERNQRYVEQSNLMMEKRNNsLQTATENTQARIlhaeqEKAKVTEELAAATAQVSHLQLKMtahQKKETELQLQLTDNL 675
Cdd:TIGR00618  256 --LKKQQLLKQLRARIEELRA-QEAVLEETQERI-----NRARKAAPLAAHIKAVTQIEQQA---QRIHTELQSKMRSRA 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   676 KEtdllRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQlelkvtslEEELTDLRAEKtSLEKNLSERKKKSAQERCQA 755
Cdd:TIGR00618  325 KL----LMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDA--------HEVATSIREIS-CQQHTLTQHIHTLQQQKTTL 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   756 EaemdEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYRevcaQRDAHQQK 835
Cdd:TIGR00618  392 T----QKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEK----LEKIHLQE 463

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 568926925   836 LALLQDECLALQAQIAAFTEQ-----KEHMQRLEKTKSQ 869
Cdd:TIGR00618  464 SAQSLKEREQQLQTKEQIHLQetrkkAVVLARLLELQEE 502
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 561-869 1.60e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 58.88  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   561 IMSNIQRIIQENERLKQELLEkssrIEEQNDKISD-LIERNQRYVEQSNLMMEKRNNSLQTATENT------QARILHAE 633
Cdd:TIGR04523  202 LLSNLKKKIQKNKSLESQISE----LKKQNNQLKDnIEKKQQEINEKTTEISNTQTQLNQLKDEQNkikkqlSEKQKELE 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   634 QEKAKVTE-------------ELAAATAQVSHLQLK--MTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREA 698
Cdd:TIGR04523  278 QNNKKIKElekqlnqlkseisDLNNQKEQDWNKELKseLKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   699 SEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAeaemdEIRKSHQEELDRLRQLLK 778
Cdd:TIGR04523  358 NSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQI-----KKLQQEKELLEKEIERLK 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   779 KARVS--------TDQAAAEQLTLAQAE-LQSQWEAKCEQLLASARDEHlQQYREVCAQRDAHQQKLALLQDECLALQAQ 849
Cdd:TIGR04523  433 ETIIKnnseikdlTNQDSVKELIIKNLDnTRESLETQLKVLSRSINKIK-QNLEQKQKELKSKEKELKKLNEEKKELEEK 511

                          330       340
                   ....*....|....*....|....
gi 568926925   850 IAAFTEQ----KEHMQRLEKTKSQ 869
Cdd:TIGR04523  512 VKDLTKKisslKEKIEKLESEKKE 535
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
516-781 2.05e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  516 EIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLlpsmsvTMETSMIMSNIQRI---IQENERLKQELLEKSSRIEEQNDK 592
Cdd:PRK03918  211 EISSELPELREELEKLEKEVKELEELKEEIEEL------EKELESLEGSKRKLeekIRELEERIEELKKEIEELEEKVKE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  593 ISDLIERNQRYVEQSNLM---------MEKRNNSLQTATENTQARILHAEQEKAKVtEELaaataqvshlqlkmtahQKK 663
Cdd:PRK03918  285 LKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEERIKELEEKEERL-EEL-----------------KKK 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  664 ETELQLQLtDNLKETDLLRGHVTRLQADLSELR-EASEQTQTKFKSEKQSrrqLELKVTSLEEELTDLRAEKTSLEKNLS 742
Cdd:PRK03918  347 LKELEKRL-EELEERHELYEEAKAKKEELERLKkRLTGLTPEKLEKELEE---LEKAKEEIEEEISKITARIGELKKEIK 422

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926925  743 ERKK-----KSAQERC-----------------QAEAEMDEIRKSHQEELDRLRQLLKKAR 781
Cdd:PRK03918  423 ELKKaieelKKAKGKCpvcgrelteehrkelleEYTAELKRIEKELKEIEEKERKLRKELR 483
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
623-805 2.43e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.24  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  623 ENTQARILHAEQEKAKVTEELAAATAQVSHLQlkmtaHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREaseqt 702
Cdd:COG4717    84 EEKEEEYAELQEELEELEEELEELEAELEELR-----EELEKLEKLLQLLPLYQELEALEAELAELPERLEELEE----- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  703 qtkfksEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARV 782
Cdd:COG4717   154 ------RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEE 227

                         170       180
                  ....*....|....*....|...
gi 568926925  783 STDQAAAEQLTLAQAELQSQWEA 805
Cdd:COG4717   228 ELEQLENELEAAALEERLKEARL 250
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 193-258 2.70e-08

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 53.95  E-value: 2.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925  193 VETGDSLEVAYTGWLLQnhvlGQVFDSTANkDKPLRLKLGSGKVVKGLEDGLLGMKKGGKR-LIITP 258
Cdd:COG1047     1 IEKGDVVTLHYTLKLED----GEVFDSTFE-GEPLEFLHGAGQLIPGLEEALEGMEVGDKKtVTLPP 62
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
567-800 2.81e-08

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 57.60  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  567 RIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQsnlmMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAA 646
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDK----LQEELEQLREELEQAREELEQLEEELEQARSELEQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  647 TAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEE 726
Cdd:COG4372    79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926925  727 LTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQ 800
Cdd:COG4372   159 LESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLG 232
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 190-308 3.03e-08

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 56.31  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  190 GPAVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSgkVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVI 269
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTLID----GKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 568926925  270 GWtqPTDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAA 308
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 569-882 3.97e-08

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 57.66  E-value: 3.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  569 IQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVE----QSNLMMEKRN---NSLQTATENTQARILHAEQE--KAKV 639
Cdd:COG5185   231 IEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLeklgENAESSKRLNenaNNLIKQFENTKEKIAEYTKSidIKKA 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  640 TEE----LAAATAQVSHLQLKMtahqKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQT--KFKSEKQsr 713
Cdd:COG5185   311 TESleeqLAAAEAEQELEESKR----ETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSseELDSFKD-- 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  714 rQLELKVTSLEEELTDLRAEKTSLEKNLSERKkksaqercqaeaemdeirKSHQEELDRLRQLLKKArVSTDQAAAEQLT 793
Cdd:COG5185   385 -TIESTKESLDEIPQNQRGYAQEILATLEDTL------------------KAADRQIEELQRQIEQA-TSSNEEVSKLLN 444

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  794 LAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAaftEQKEHMQR-LEKTKSQAPA 872
Cdd:COG5185   445 ELISELNKVMREADEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLE---KLRAKLERqLEGVRSKLDQ 521

                         330
                  ....*....|
gi 568926925  873 GRAAADPSEK 882
Cdd:COG5185   522 VAESLKDFMR 531
PTZ00121 PTZ00121
MAEBL; Provisional
 573-798 4.65e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 4.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  573 ERLKQELLEKSSRIEEQNDKisdliernqRYVEQSNLMMEKRNNSLQTATENTQArilhaeqEKAKVTEELaaataQVSH 652
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKA-------EEARIEEVM-----KLYE 1602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  653 LQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSE-------LREASEQT-----QTKFKSEKQSRRQLELKV 720
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEekkkaeeLKKAEEENkikaaEEAKKAEEDKKKAEEAKK 1682

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925  721 TSLEEELTDLRAEKTSLEKNLSER-KKKSAQERCQAEaemdEIRKSHQEELDRLRQLLKKARvsTDQAAAEQLTLAQAE 798
Cdd:PTZ00121 1683 AEEDEKKAAEALKKEAEEAKKAEElKKKEAEEKKKAE----ELKKAEEENKIKAEEAKKEAE--EDKKKAEEAKKDEEE 1755
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 493-758 5.48e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.42  E-value: 5.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   493 APHFQGSGDMMSFLMT--EARQHNTEIRMAVNKVADKmdHLMTKVEELQKH------------SSGNSMLLPSMSVTMET 558
Cdd:pfam05483  431 AEELKGKEQELIFLLQarEKEIHDLEIQLTAIKTSEE--HYLKEVEDLKTElekeklknieltAHCDKLLLENKELTQEA 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   559 S---MIMSNIQRIIQENERLKQELLEKSSRIEE------------------QNDKIS---DLIERNQRYVEQSNLMMEKR 614
Cdd:pfam05483  509 SdmtLELKKHQEDIINCKKQEERMLKQIENLEEkemnlrdelesvreefiqKGDEVKcklDKSEENARSIEYEVLKKEKQ 588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   615 N-------NSLQTATENTQARILHAEQE----KAKVTEE---LAAATAQVSHLQLKMTAHQKKETEL----QLQLTDN-L 675
Cdd:pfam05483  589 MkilenkcNNLKKQIENKNKNIEELHQEnkalKKKGSAEnkqLNAYEIKVNKLELELASAKQKFEEIidnyQKEIEDKkI 668

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   676 KETDLL----RGHVT-----RLQ-----------ADLSELREASEQTQTKFKSEKQS---------RRQLELKVtSLEEE 726
Cdd:pfam05483  669 SEEKLLeeveKAKAIadeavKLQkeidkrcqhkiAEMVALMEKHKHQYDKIIEERDSelglyknkeQEQSSAKA-ALEIE 747

                          330       340       350
                   ....*....|....*....|....*....|...
gi 568926925   727 LTDLRAEKTSLEKNLS-ERKKKsaqERCQAEAE 758
Cdd:pfam05483  748 LSNIKAELLSLKKQLEiEKEEK---EKLKMEAK 777
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 633-869 6.21e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.39  E-value: 6.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   633 EQEKAKVTEELAAATAQVSHLQLKmtahqkkETELQLQLtDNLKETdllRGHVTRLQADLSELR--EASEQTQTKFKSEK 710
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLI-------IDEKRQQL-ERLRRE---REKAERYQALLKEKReyEGYELLKEKEALER 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   711 QsRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRL----RQLLKKARVSTDQ 786
Cdd:TIGR02169  238 Q-KEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELeaeiASLERSIAEKERE 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   787 A--AAEQLTLAQAELQSQwEAKCEQLlasarDEHLQQYRevcAQRDAHQQKLALLQDECLALQAQI--------AAFTEQ 856
Cdd:TIGR02169  317 LedAEERLAKLEAEIDKL-LAEIEEL-----EREIEEER---KRRDKLTEEYAELKEELEDLRAELeevdkefaETRDEL 387

                          250
                   ....*....|...
gi 568926925   857 KEHMQRLEKTKSQ 869
Cdd:TIGR02169  388 KDYREKLEKLKRE 400
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 559-817 6.43e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.95  E-value: 6.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   559 SMIMSNIQRIIQENER---LKQEL-------LEKSSRIEEQNDKISDLIERNQRYVEQS-NLMMEKR--NNSLQTATENT 625
Cdd:TIGR04523  328 NQISQNNKIISQLNEQisqLKKELtnsesenSEKQRELEEKQNEIEKLKKENQSYKQEIkNLESQINdlESKIQNQEKLN 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   626 Q---ARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQT 702
Cdd:TIGR04523  408 QqkdEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQK 487

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   703 QTKFKSE-------KQSRRQLELKV-------TSLEEELTDLRAEKTSLEKNLSERKKK-----SAQERCQAEAEMDEIr 763
Cdd:TIGR04523  488 QKELKSKekelkklNEEKKELEEKVkdltkkiSSLKEKIEKLESEKKEKESKISDLEDElnkddFELKKENLEKEIDEK- 566

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925   764 kshQEELDRLRQLLKKARVSTDQAA--AEQLTLAQAELQSQWEAKcEQLLASARDE 817
Cdd:TIGR04523  567 ---NKEIEELKQTQKSLKKKQEEKQelIDQKEKEKKDLIKEIEEK-EKKISSLEKE 618
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 627-779 9.01e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 9.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  627 ARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQT--QT 704
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEalQK 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  705 KFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKK 779
Cdd:COG1579    97 EIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 658-830 9.35e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 9.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  658 TAHQKKETELQLQLTDNlkETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSL 737
Cdd:COG1579     1 AMPEDLRALLDLQELDS--ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  738 EKNLSE----------RKKKSAQERCQAEAE------MDEI------RKSHQEELDRLRQLLKKARVSTDQAAAEqltlA 795
Cdd:COG1579    79 EEQLGNvrnnkeyealQKEIESLKRRISDLEdeilelMERIeeleeeLAELEAELAELEAELEEKKAELDEELAE----L 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568926925  796 QAELQSQwEAKCEQLLASARDEHLQQYREVCAQRD 830
Cdd:COG1579   155 EAELEEL-EAEREELAAKIPPELLALYERIRKRKN 188
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
574-870 9.52e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.59  E-value: 9.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  574 RLKQELLEKSSRIEEQNDKIsdliERNQRYVEQSNLMM----EKRN--NSLQTATENTQARILHAEQEKAKVTEELAAAT 647
Cdd:PRK02224  210 GLESELAELDEEIERYEEQR----EQARETRDEADEVLeeheERREelETLEAEIEDLRETIAETEREREELAEEVRDLR 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  648 AQVSHLQ---------------------LKMTAHQKKETELQ-------LQLTDNLKETDLLRGHVTRLQADLSELREAS 699
Cdd:PRK02224  286 ERLEELEeerddllaeaglddadaeaveARREELEDRDEELRdrleecrVAAQAHNEEAESLREDADDLEERAEELREEA 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  700 EQTQTKFKSEKQSRRQLELKVTSLEEELTDLRaektsleknlsERKKKSAQERCQAEAEMDEIRkshqEELDRLRQLLKK 779
Cdd:PRK02224  366 AELESELEEAREAVEDRREEIEELEEEIEELR-----------ERFGDAPVDLGNAEDFLEELR----EERDELREREAE 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  780 ARVSTdQAAAEQLTLAQAELQSQWEAKCEQLLA-SARDEHLQQYREvcaQRDAHQQKLALLQDECLALQAQIAAFTEQKE 858
Cdd:PRK02224  431 LEATL-RTARERVEEAEALLEAGKCPECGQPVEgSPHVETIEEDRE---RVEELEAELEDLEEEVEEVEERLERAEDLVE 506

                         330
                  ....*....|..
gi 568926925  859 HMQRLEKTKSQA 870
Cdd:PRK02224  507 AEDRIERLEERR 518
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
641-849 1.04e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  641 EELAAATAQVSHLQLKMTAHQK-KETELQLQLTDNLKEtdllRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELK 719
Cdd:COG4913   242 EALEDAREQIELLEPIRELAERyAAARERLAELEYLRA----ALRLWFAQRRLELLEAELEELRAELARLEAELERLEAR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  720 VTSLEEELTDLRAEktsLEKNLSERKKKSAQERCQAEAEMDEIrkshQEELDRLRQLLKKARVSTDQAAAEQltlaqAEL 799
Cdd:COG4913   318 LDALREELDELEAQ---IRGNGGDRLEQLEREIERLERELEER----ERRRARLEALLAALGLPLPASAEEF-----AAL 385

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568926925  800 QSQWEAKCEQLlASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQ 849
Cdd:COG4913   386 RAEAAALLEAL-EEELEALEEALAEAEAALRDLRRELRELEAEIASLERR 434
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 619-872 1.21e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.54  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  619 QTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREA 698
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  699 SEQTQTK--------FKSEKQSRRQLELKVTSLEEELTDLRAektsLEKNLSERKKksaqercqaeaEMDEIRKShQEEL 770
Cdd:COG4942    99 LEAQKEElaellralYRLGRQPPLALLLSPEDFLDAVRRLQY----LKYLAPARRE-----------QAEELRAD-LAEL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  771 DRLRQLLKKARvstdqaaaEQLTLAQAELQSQweakcEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQI 850
Cdd:COG4942   163 AALRAELEAER--------AELEALLAELEEE-----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229

                         250       260
                  ....*....|....*....|..
gi 568926925  851 AAFteQKEHMQRLEKTKSQAPA 872
Cdd:COG4942   230 ARL--EAEAAAAAERTPAAGFA 249
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
562-841 2.08e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 54.52  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  562 MSNIQRIIQENERLKQELLEKSSRIEEQNDKISDL---IERNQRYVEQSNLMMEKrnnsLQTATENTQARILHAEQEKAK 638
Cdd:COG4372    37 LFELDKLQEELEQLREELEQAREELEQLEEELEQArseLEQLEEELEELNEQLQA----AQAELAQAQEELESLQEEAEE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELRE-----ASEQTQTKFKSEKQSR 713
Cdd:COG4372   113 LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQelqalSEAEAEQALDELLKEA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  714 RQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKK-ARVSTDQAAAEQL 792
Cdd:COG4372   193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKeIEELELAILVEKD 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  793 TLAQAELQSQWEAKCE--QLLASARDEHLQQYREVCAQRDAHQQKLALLQD 841
Cdd:COG4372   273 TEEEELEIAALELEALeeAALELKLLALLLNLAALSLIGALEDALLAALLE 323
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 528-870 2.40e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.51  E-value: 2.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   528 MDHLMTKVEELQKHSSGNSMLLPSMSVTMETSM--IMSNIQRiiqenerlKQELLEKSSRIEEQNDKISDLIERNQRYVE 605
Cdd:pfam15921  414 IDHLRRELDDRNMEVQRLEALLKAMKSECQGQMerQMAAIQG--------KNESLEKVSSLTAQLESTKEMLRKVVEELT 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   606 QSNLMMEKRNNSLQTATENTQARILHAEQEKAKVT----------EELAAATAQVSHLQlkmtaHQKKETE-LQLQLTDN 674
Cdd:pfam15921  486 AKKMTLESSERTVSDLTASLQEKERAIEATNAEITklrsrvdlklQELQHLKNEGDHLR-----NVQTECEaLKLQMAEK 560

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   675 LKETDLLRGHVTRLQADLSEL-REASEQTQTKFKSEKQ-SRRQLEL------------KVTSLEEELTDLRAEKTSLEKN 740
Cdd:pfam15921  561 DKVIEILRQQIENMTQLVGQHgRTAGAMQVEKAQLEKEiNDRRLELqefkilkdkkdaKIRELEARVSDLELEKVKLVNA 640

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   741 LSER---KKKSAQERCQAeaeMDEIRKSHQE--ELDRLRQLLKKarvsTDQAAAEQLTLAQAELQSQweakceqlLASAR 815
Cdd:pfam15921  641 GSERlraVKDIKQERDQL---LNEVKTSRNElnSLSEDYEVLKR----NFRNKSEEMETTTNKLKMQ--------LKSAQ 705

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925   816 DEhLQQYREVCAQ---RDAHQQKLAL-LQDECLALQAQIAAFTEQkehMQRLEKTKSQA 870
Cdd:pfam15921  706 SE-LEQTRNTLKSmegSDGHAMKVAMgMQKQITAKRGQIDALQSK---IQFLEEAMTNA 760
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 662-946 2.52e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  662 KKETELQLQLT-DNLKE-TDLLRGhvtrLQADLSELREASEQTQtKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEK 739
Cdd:COG1196   174 KEEAERKLEATeENLERlEDILGE----LERQLEPLERQAEKAE-RYRELKEELKELEAELLLLKLRELEAELEELEAEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  740 NLSERKKKSAQ-ERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEH 818
Cdd:COG1196   249 EELEAELEELEaELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  819 LQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQkehmqRLEKTKSQAPAGRAAADPSEKVKKIMNQVFQSLRGEF 898
Cdd:COG1196   329 EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA-----LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 568926925  899 ELEESydggtiLRTIMHTIKMVTLQLLNHQEEEEEEEEEEEEEKKPLR 946
Cdd:COG1196   404 ELEEA------EEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 506-904 2.69e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 55.11  E-value: 2.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   506 LMTEARQHNTEIRMAVNKVADKMDHLMTKVE-ELQKHSSGNSMLLPSMSvtmETSMIMSNIQRIIQENeRLKQELLEKSS 584
Cdd:pfam05483  202 LRVQAENARLEMHFKLKEDHEKIQHLEEEYKkEINDKEKQVSLLLIQIT---EKENKMKDLTFLLEES-RDKANQLEEKT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   585 RIEEQNDKisDLIERNQ---RYVEQSNLMMEKRNNSLQTATENTQArilhAEQEKAKVTEElaaATAQVSHLQLKMTAHQ 661
Cdd:pfam05483  278 KLQDENLK--ELIEKKDhltKELEDIKMSLQRSMSTQKALEEDLQI----ATKTICQLTEE---KEAQMEELNKAKAAHS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   662 KKETELQlQLTDNLKEtdLLRGHVTRLQADLSEL--------REASE-QTQTKFKSEKQSRRQlELKVTSLEEEltDLRA 732
Cdd:pfam05483  349 FVVTEFE-ATTCSLEE--LLRTEQQRLEKNEDQLkiitmelqKKSSElEEMTKFKNNKEVELE-ELKKILAEDE--KLLD 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   733 EKTSLEKnLSERKKKSAQERC---QA--------EAEMDEIRKSHQ---EELDRLRQLLKKARVSTDQ--AAAEQLTLAQ 796
Cdd:pfam05483  423 EKKQFEK-IAEELKGKEQELIfllQArekeihdlEIQLTAIKTSEEhylKEVEDLKTELEKEKLKNIEltAHCDKLLLEN 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   797 AELQSQWEAKCEQLLASARD--EHLQQYREVCAQRDAHQQKLALLQDEclaLQAQIAAFTEQKEHMQ-RLEKTKSQAPAG 873
Cdd:pfam05483  502 KELTQEASDMTLELKKHQEDiiNCKKQEERMLKQIENLEEKEMNLRDE---LESVREEFIQKGDEVKcKLDKSEENARSI 578

                          410       420       430
                   ....*....|....*....|....*....|.
gi 568926925   874 RAAADPSEKVKKIMNQVFQSLRGEFELEESY 904
Cdd:pfam05483  579 EYEVLKKEKQMKILENKCNNLKKQIENKNKN 609
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 561-744 3.70e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.62  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERnqryVEQsnlmMEKRNNSLQTATENTQARILHAE--QEKAK 638
Cdd:COG1579    15 LDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE----LED----LEKEIKRLELEIEEVEARIKKYEeqLGNVR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVSHLQLKMTAHQKKETELQLQLtdnlketdllrghvTRLQADLSELREASEQTQTKFKSEKQsrrQLEL 718
Cdd:COG1579    87 NNKEYEALQKEIESLKRRISDLEDEILELMERI--------------EELEEELAELEAELAELEAELEEKKA---ELDE 149

                         170       180
                  ....*....|....*....|....*.
gi 568926925  719 KVTSLEEELTDLRAEKTSLEKNLSER 744
Cdd:COG1579   150 ELAELEAELEELEAEREELAAKIPPE 175
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 574-847 3.89e-07

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 53.66  E-value: 3.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   574 RLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAataqvshl 653
Cdd:pfam15905   55 KVKSLELKKKSQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVAS-------- 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   654 qlkmtahqkketeLQLQLTDNLKETDLLR------GHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEEL 727
Cdd:pfam15905  127 -------------LEKQLLELTRVNELLKakfsedGTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNL 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   728 TDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQ--EELDRLRQLLKKARVSTDQAAAEQLTLAQA------EL 799
Cdd:pfam15905  194 EHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCvsEQVEKYKLDIAQLEELLKEKNDEIESLKQSleekeqEL 273

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925   800 QSQWE---AKCeQLLASARDEHLQQYREVCAQRDAH----QQKLALLQDECLALQ 847
Cdd:pfam15905  274 SKQIKdlnEKC-KLLESEKEELLREYEEKEQTLNAEleelKEKLTLEEQEHQKLQ 327
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 528-862 4.46e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 54.13  E-value: 4.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   528 MDHLMTKVEELQKHSSGNSMLLPSMSVTMetsmimsnIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQS 607
Cdd:pfam07888    3 LDELVTLEEESHGEEGGTDMLLVVPRAEL--------LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   608 NLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQlQLTDNLKETDLLRghvtr 687
Cdd:pfam07888   75 RRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELE-EDIKTLTQRVLER----- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   688 lQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQ 767
Cdd:pfam07888  149 -ETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHR 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   768 EELDrLRQLLKKARVSTDQAAAEQLTLA----------------QAEL-QSQWEAKCEQLLASARDEHLQQYREVCAQ-R 829
Cdd:pfam07888  228 KEAE-NEALLEELRSLQERLNASERKVEglgeelssmaaqrdrtQAELhQARLQAAQLTLQLADASLALREGRARWAQeR 306

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 568926925   830 DAHQQKLALLQDECLALQAQIAAFTE--QKEHMQR 862
Cdd:pfam07888  307 ETLQQSAEADKDRIEKLSAELQRLEErlQEERMER 341
PRK11281 PRK11281
mechanosensitive channel MscK;
632-879 5.49e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 54.15  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  632 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETE-LQLQLTDNLKETdllrghvTRLQADLSELReASEQTQTKFKSEK 710
Cdd:PRK11281   49 NKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEqLKQQLAQAPAKL-------RQAQAELEALK-DDNDEETRETLST 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  711 QSRRQLELKVTSLEEELTDLRAEKTSLEKNLSerKKKSAQERCQAEaeMDEirksHQEELDRLRQLLKKARVSTDQAAAE 790
Cdd:PRK11281  121 LSLRQLESRLAQTLDQLQNAQNDLAEYNSQLV--SLQTQPERAQAA--LYA----NSQRLQQIRNLLKGGKVGGKALRPS 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  791 QLTLAQAELQSqWEAKCE---QLLASArdEHLQQYREvcAQRDAHQQKLALLQDECLALQAQIAA--FTEQKEHMQRLEk 865
Cdd:PRK11281  193 QRVLLQAEQAL-LNAQNDlqrKSLEGN--TQLQDLLQ--KQRDYLTARIQRLEHQLQLLQEAINSkrLTLSEKTVQEAQ- 266

                         250
                  ....*....|....
gi 568926925  866 tkSQAPAGRAAADP 879
Cdd:PRK11281  267 --SQDEAARIQANP 278
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 661-951 7.41e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.92  E-value: 7.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   661 QKKETELQLQLTDNLKETDLLRGHVTRLQadlSELREASEQTqtkfkSEKQSRRQ-LELKVTSLEEELTDL--------- 730
Cdd:TIGR02169  680 RERLEGLKRELSSLQSELRRIENRLDELS---QELSDASRKI-----GEIEKEIEqLEQEEEKLKERLEELeedlssleq 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   731 -----RAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEqltlAQAELQSqwEA 805
Cdd:TIGR02169  752 eienvKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLNR--LT 825

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   806 KCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAaftEQKEHMQRLEKTKSqapagraaaDPSEKVKK 885
Cdd:TIGR02169  826 LEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE---ELEAALRDLESRLG---------DLKKERDE 893

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925   886 IMNQVFQSLRGEFELEESYDggtILRTIMHTIKmVTLQLLNHQEEEEEEEEEEEEEKKPLRPSLEQ 951
Cdd:TIGR02169  894 LEAQLRELERKIEELEAQIE---KKRKRLSELK-AKLEALEEELSEIEDPKGEDEEIPEEELSLED 955
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 632-852 9.38e-07

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 51.53  E-value: 9.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   632 AEQEKAKVTEELAAATAQV--SHLQL--KMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSElreaseqtQTKFK 707
Cdd:pfam12795    3 DELEKAKLDEAAKKKLLQDlqQALSLldKIDASKQRAAAYQKALDDAPAELRELRQELAALQAKAEA--------APKEI 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   708 SEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQercqAEAEMDEIRKshqeELDRLRQLLKKARVSTDQA 787
Cdd:pfam12795   75 LASLSLEELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPER----AQQQLSEARQ----RLQQIRNRLNGPAPPGEPL 146

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925   788 AAEQLTLAQAELQSQW----EAKCEQLLASARDEHLQqyrevcAQRDAHQQKLALLQDECLALQAQIAA 852
Cdd:pfam12795  147 SEAQRWALQAELAALKaqidMLEQELLSNNNRQDLLK------ARRDLLTLRIQRLEQQLQALQELLNE 209
PTZ00121 PTZ00121
MAEBL; Provisional
 570-885 1.14e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  570 QENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRN--NSLQTATENTQARILHAEQEKAKVTEELA--A 645
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaeEAKKKAEEAKKADEAKKKAEEAKKADEAKkkA 1492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  646 ATAQVSHLQLKMTAHQKKETElQLQLTDNLKETDLLRGHVTRLQAD----------------LSELREASEQTQTKFKSE 709
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKAD-EAKKAEEAKKADEAKKAEEAKKADeakkaeekkkadelkkAEELKKAEEKKKAEEAKK 1571

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  710 KQSRRQLELK---------------VTSLEEELTDLRAEKT-----------SLEKNLSERKKKSAQERCQAEA--EMDE 761
Cdd:PTZ00121 1572 AEEDKNMALRkaeeakkaeearieeVMKLYEEEKKMKAEEAkkaeeakikaeELKKAEEEKKKVEQLKKKEAEEkkKAEE 1651

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  762 IRKSHQEELDRLRQLLKKARvsTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYREVcAQRDAHQQKLAllqD 841
Cdd:PTZ00121 1652 LKKAEEENKIKAAEEAKKAE--EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAE-EKKKAEELKKA---E 1725

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 568926925  842 ECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAADPSEKVKK 885
Cdd:PTZ00121 1726 EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK 1769
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 574-904 1.25e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.05  E-value: 1.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   574 RLKQELLEKSsriEEQNDKISDLIERNQryVEQSNLMMEKRNNSLQTATEntqarilhAEQEKAKVTEELAAATAQVSHl 653
Cdd:TIGR00618  153 EFAQFLKAKS---KEKKELLMNLFPLDQ--YTQLALMEFAKKKSLHGKAE--------LLTLRSQLLTLCTPCMPDTYH- 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   654 qlkmTAHQKKETELQlQLTDNLKETDllrghvtRLQADLSELREASEQTQTKFKSEKQSRRQLElKVTSLEEELtdlraE 733
Cdd:TIGR00618  219 ----ERKQVLEKELK-HLREALQQTQ-------QSHAYLTQKREAQEEQLKKQQLLKQLRARIE-ELRAQEAVL-----E 280

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   734 KTSLEKNLSERKKKSAQErcqaEAEMDEIRKSHQEELDRLRQ---LLKKARVSTDQAAAEQLTL-AQAELQSQWEAKCEQ 809
Cdd:TIGR00618  281 ETQERINRARKAAPLAAH----IKAVTQIEQQAQRIHTELQSkmrSRAKLLMKRAAHVKQQSSIeEQRRLLQTLHSQEIH 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   810 LlasaRDEHLQQyrevCAQRDAHQQKLALLQdECLALQAQIAAFTEQkehMQRLEKTKSQAPAGRAAADPSEKVKKIMNQ 889
Cdd:TIGR00618  357 I----RDAHEVA----TSIREISCQQHTLTQ-HIHTLQQQKTTLTQK---LQSLCKELDILQREQATIDTRTSAFRDLQG 424

                          330
                   ....*....|....*
gi 568926925   890 VFQSLRGEFELEESY 904
Cdd:TIGR00618  425 QLAHAKKQQELQQRY 439
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
569-859 1.51e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.46  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  569 IQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEqsnlmMEKRNNSLQTATEN--TQARILHAEQEKAKVTEELAAA 646
Cdd:COG4717    70 LKELKELEEELKEAEEKEEEYAELQEELEELEEELEE-----LEAELEELREELEKleKLLQLLPLYQELEALEAELAEL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  647 TAQVSHLQLKMTAHQKKETELQlQLTDNLKEtdlLRGHVTRLQADLS-ELREASEQTQTKFKSEKQSRRQLELKVTSLEE 725
Cdd:COG4717   145 PERLEELEERLEELRELEEELE-ELEAELAE---LQEELEELLEQLSlATEEELQDLAEELEELQQRLAELEEELEEAQE 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  726 ELTDLRAEKTSLEKNL--------------------------------------------------------SERKKKSA 749
Cdd:COG4717   221 ELEELEEELEQLENELeaaaleerlkearlllliaaallallglggsllsliltiagvlflvlgllallfllLAREKASL 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  750 QERCQAEAEMDEIRKSHQEELDRLRQLL-------------KKARVSTDQAAAEQLTLAQAELQ-SQWEAKCEQLLASAR 815
Cdd:COG4717   301 GKEAEELQALPALEELEEEELEELLAALglppdlspeelleLLDRIEELQELLREAEELEEELQlEELEQEIAALLAEAG 380

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 568926925  816 DEHLQQYREVCAQRDAHQQKLALLQDeclaLQAQIAAFTEQKEH 859
Cdd:COG4717   381 VEDEEELRAALEQAEEYQELKEELEE----LEEQLEELLGELEE 420
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 570-869 2.14e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 52.48  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   570 QENERLKQELLEKSSRIEEQNDKISDLIERnqryVEQSNLMMEKRNNSLQTATENTQarilhaeqekakvtEELAAATAQ 649
Cdd:pfam01576  422 SESERQRAELAEKLSKLQSELESVSSLLNE----AEGKNIKLSKDVSSLESQLQDTQ--------------ELLQEETRQ 483

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   650 VSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELR----------EASEQTQTKFKSEKQSRRQ---- 715
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKkkleedagtlEALEEGKKRLQRELEALTQqlee 563

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   716 -------LELKVTSLEEELTDL-------RAEKTSLEKN-------LSERKKKSAQ---ERCQAEAEMDEIR-------- 763
Cdd:pfam01576  564 kaaaydkLEKTKNRLQQELDDLlvdldhqRQLVSNLEKKqkkfdqmLAEEKAISARyaeERDRAEAEAREKEtralslar 643

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   764 -----KSHQEELDRLRQLLK---------------------KARVSTDQAAAE---QLTLAQAELQSQWEAKCE-----Q 809
Cdd:pfam01576  644 aleeaLEAKEELERTNKQLRaemedlvsskddvgknvheleRSKRALEQQVEEmktQLEELEDELQATEDAKLRlevnmQ 723

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   810 LLA-------SARDEH--------LQQYREVCAQRDAH--QQKLAL-----LQDECLALQAQI-AAFTEQKEHMQRLEKT 866
Cdd:pfam01576  724 ALKaqferdlQARDEQgeekrrqlVKQVRELEAELEDErkQRAQAVaakkkLELDLKELEAQIdAANKGREEAVKQLKKL 803


                   ...
gi 568926925   867 KSQ 869
Cdd:pfam01576  804 QAQ 806
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
580-871 2.26e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  580 LEKSSRIEEQNDKISDLIER--------NQRYVEQ--------SNLMMEK------RNNSLQTATENTQARILHAEQEKA 637
Cdd:PRK03918  100 LDGSEVLEEGDSSVREWVERlipyhvflNAIYIRQgeidaileSDESREKvvrqilGLDDYENAYKNLGEVIKEIKRRIE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  638 KVtEELAAATAQVSHLqLKmtaHQKKETELQLQ----LTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSR 713
Cdd:PRK03918  180 RL-EKFIKRTENIEEL-IK---EKEKELEEVLReineISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSK 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  714 RQLELKVTSLEEELTDLRAEKTSLEKNLSERK--KKSAQERCQAEAEMDEIRKSHQE---ELDRLRQLLKK-----ARVS 783
Cdd:PRK03918  255 RKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYLDELREiekRLSRLEEEINGieeriKELE 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  784 TDQAAAEQLTLAQAELQSQWEA--KCEQLLASARD--EHLQQYR---------EVCAQRDAHQQKLALLQDECLALQAQI 850
Cdd:PRK03918  335 EKEERLEELKKKLKELEKRLEEleERHELYEEAKAkkEELERLKkrltgltpeKLEKELEELEKAKEEIEEEISKITARI 414

                         330       340
                  ....*....|....*....|....*
gi 568926925  851 AAF----TEQKEHMQRLEKTKSQAP 871
Cdd:PRK03918  415 GELkkeiKELKKAIEELKKAKGKCP 439
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 570-861 2.58e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.43  E-value: 2.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   570 QENERLKQELLEKSSRIEEQ----NDKISDLiERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAA 645
Cdd:pfam07888   69 EQWERQRRELESRVAELKEElrqsREKHEEL-EEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLE 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   646 ATAQVSHL---QLKMTAHQKKETELQLQLTDNLKETDllrGHVTRLQADLSELREASEQTQTkfksekqSRRQLELKVTS 722
Cdd:pfam07888  148 RETELERMkerAKKAGAQRKEEEAERKQLQAKLQQTE---EELRSLSKEFQELRNSLAQRDT-------QVLQLQDTITT 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   723 LEEELTDlrAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEEL----DRLRQLLKKARVstdQAAAEQLTLAQAE 798
Cdd:pfam07888  218 LTQKLTT--AHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMaaqrDRTQAELHQARL---QAAQLTLQLADAS 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   799 L-----QSQWEAKCEQLLASARDEH----------------LQQYR--------EVCAQRDAHQQKLALLQDECLALQAQ 849
Cdd:pfam07888  293 LalregRARWAQERETLQQSAEADKdrieklsaelqrleerLQEERmereklevELGREKDCNRVQLSESRRELQELKAS 372

                          330
                   ....*....|..
gi 568926925   850 IAAFTEQKEHMQ 861
Cdd:pfam07888  373 LRVAQKEKEQLQ 384
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 577-870 2.72e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 51.76  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  577 QELLEkssRIEEQNDKIsdliernqRYVEQSNLMmeKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQV----SH 652
Cdd:PRK04778   85 EEQLF---EAEELNDKF--------RFRKAKHEI--NEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLkdlyRE 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  653 LQLKMTAH-------------QKKETELQLQLTDNLKET----------DLLRGHVTRLQADLSELREASEQTQTKFKSE 709
Cdd:PRK04778  152 LRKSLLANrfsfgpaldelekQLENLEEEFSQFVELTESgdyveareilDQLEEELAALEQIMEEIPELLKELQTELPDQ 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  710 ----KQSRRQLE-----LKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQA-EAEMDEI----------RKSHQEE 769
Cdd:PRK04778  232 lqelKAGYRELVeegyhLDHLDIEKEIQDLKEQIDENLALLEELDLDEAEEKNEEiQERIDQLydilerevkaRKYVEKN 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  770 LDRLRQLLKKARVSTDQAAAE--------QLTLAQAELQSQWEAKCEQLLAsardehlqQYREVCAQRDAHQQKLALLQD 841
Cdd:PRK04778  312 SDTLPDFLEHAKEQNKELKEEidrvkqsyTLNESELESVRQLEKQLESLEK--------QYDEITERIAEQEIAYSELQE 383

                         330       340       350
                  ....*....|....*....|....*....|...
gi 568926925  842 ECLALQAQIAAFTEQ----KEHMQRLEKTKSQA 870
Cdd:PRK04778  384 ELEEILKQLEEIEKEqeklSEMLQGLRKDELEA 416
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 576-775 2.80e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  576 KQELLEKSSRIEEQNDKISDLIERNQRYVEQsnlmMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQL 655
Cdd:COG1579     5 DLRALLDLQELDSELDRLEHRLKELPAELAE----LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  656 KMTAHqKKETELQ-LQltdnlKETDLLRGHVTRLQADLSELREASEQTQTKFKsekqsrrQLELKVTSLEEELTDLRAEk 734
Cdd:COG1579    81 QLGNV-RNNKEYEaLQ-----KEIESLKRRISDLEDEILELMERIEELEEELA-------ELEAELAELEAELEEKKAE- 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568926925  735 tsleknLSERKKKSAQERCQAEAEMDEIRKSHQEEL----DRLRQ 775
Cdd:COG1579   147 ------LDEELAELEAELEELEAEREELAAKIPPELlalyERIRK 185
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
686-913 3.14e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.06  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  686 TRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKkksaQERCQAEAEMDEIrks 765
Cdd:COG4372     6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLE----EELEQARSELEQL--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  766 hQEELDRLRQLLKKARVSTDQAAaEQLTLAQAELQSqweakceqlLASARDEHLQQYREVCAQRDAHQQKLALLQDECLA 845
Cdd:COG4372    79 -EEELEELNEQLQAAQAELAQAQ-EELESLQEEAEE---------LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAE 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925  846 LQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAADPSEKVKKIMNQVFQSLRGEFELEESYDGGTILRTI 913
Cdd:COG4372   148 REEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRE 215
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 566-928 3.22e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.65  E-value: 3.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   566 QRIIQENERLKQELL---EKSS-RIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTAT----ENTQARILHAE---- 633
Cdd:pfam05483  112 RKIIEAQRKAIQELQfenEKVSlKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKkyeyEREETRQVYMDlnnn 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   634 -QEKAKVTEEL--AAATAQVS-HLQLKMTAH--QKKETELQLQLTDNLKETDLLRGHVTRLQADLSEL-------REASE 700
Cdd:pfam05483  192 iEKMILAFEELrvQAENARLEmHFKLKEDHEkiQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLtflleesRDKAN 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   701 QTQTKFKSEKQSRRQLELKVTSLEEELTDLR-------AEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQE----- 768
Cdd:pfam05483  272 QLEEKTKLQDENLKELIEKKDHLTKELEDIKmslqrsmSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAhsfvv 351

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   769 -ELD----RLRQLLK--KARVSTDQaaaEQLTLAQAELQSQW-------------EAKCEQLLAS-ARDEHL----QQYR 823
Cdd:pfam05483  352 tEFEattcSLEELLRteQQRLEKNE---DQLKIITMELQKKSseleemtkfknnkEVELEELKKIlAEDEKLldekKQFE 428

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   824 EVCAQRDAHQQKLALL----QDECLALQAQIAAFTEQKEH-MQRLEKTKSQAPagraaadpSEKVKKI---MNQVFQSLR 895
Cdd:pfam05483  429 KIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHyLKEVEDLKTELE--------KEKLKNIeltAHCDKLLLE 500

                          410       420       430
                   ....*....|....*....|....*....|...
gi 568926925   896 GEFELEESYDggtilrtimhtikmVTLQLLNHQ 928
Cdd:pfam05483  501 NKELTQEASD--------------MTLELKKHQ 519
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 589-864 3.62e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 51.49  E-value: 3.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  589 QNDKISDLIERNQRYVeQSNLMM---EKRNNSLQTAT-ENTQA---RILHAEQEK-AKVTEELAAATAQVSHLQlkmTAH 660
Cdd:COG3096   254 DRDLFKHLITEATNYV-AADYMRhanERRELSERALElRRELFgarRQLAEEQYRlVEMARELEELSARESDLE---QDY 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  661 QKKETELQLQLTdNLKetdlLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKN 740
Cdd:COG3096   330 QAASDHLNLVQT-ALR----QQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQA 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  741 LSE------------RKKKSAQERCQ--------AEAEMDEIRKSHQEELDRLRQLlkKARVSTDQAAAEQLTLAQAELQ 800
Cdd:COG3096   405 LDVqqtraiqyqqavQALEKARALCGlpdltpenAEDYLAAFRAKEQQATEEVLEL--EQKLSVADAARRQFEKAYELVC 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  801 S---------QWEAKCEQLLASARDEHL--------QQYREvcAQRDAHQQKLA--LLQDECLALQAQIAAFTEQKEHMQ 861
Cdd:COG3096   483 KiageversqAWQTARELLRRYRSQQALaqrlqqlrAQLAE--LEQRLRQQQNAerLLEEFCQRIGQQLDAAEELEELLA 560


                  ...
gi 568926925  862 RLE 864
Cdd:COG3096   561 ELE 563
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
686-945 3.63e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  686 TRLQADLSELREASEQTQtKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLseRKKKSAQERCQAEAEMDEIrks 765
Cdd:COG4717    71 KELKELEEELKEAEEKEE-EYAELQEELEELEEELEELEAELEELREELEKLEKLL--QLLPLYQELEALEAELAEL--- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  766 hQEELDRLRQllKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDE---HLQQYREVCAQRDAHQQKLALLQDE 842
Cdd:COG4717   145 -PERLEELEE--RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElqdLAEELEELQQRLAELEEELEEAQEE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  843 CLALQAQIAAFTEQKEHMQRLE---------------------------------------------------KTKSQAP 871
Cdd:COG4717   222 LEELEEELEQLENELEAAALEErlkearlllliaaallallglggsllsliltiagvlflvlgllallflllaREKASLG 301

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926925  872 AGRAAADPSEKVKKIMNQVFQSLRGEFELEESYDGGTILRTIMHTIKMVTLQLLNHQEEEEEEEEEEEEEKKPL 945
Cdd:COG4717   302 KEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAL 375
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
552-824 3.80e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 50.29  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  552 MSVTMETSM---IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQAR 628
Cdd:COG1340     1 SKTDELSSSleeLEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  629 ILHAEQEKaKVTEELAAATAQVSHLQLKMTAHQKKETEL-QL---QLTDNL---KETDLLRgHVTRLQADLSELREASEQ 701
Cdd:COG1340    81 DELNEKLN-ELREELDELRKELAELNKAGGSIDKLRKEIeRLewrQQTEVLspeEEKELVE-KIKELEKELEKAKKALEK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  702 ------TQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKS---AQERCQAEAEMDEIRKSH---QEE 769
Cdd:COG1340   159 neklkeLRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEAdelHKEIVEAQEKADELHEEIielQKE 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925  770 LDRLRQLLKKARvstDQAAAEQLTLAQAELQSQWEAKCEQLLASAR---DEHLQQYRE 824
Cdd:COG1340   239 LRELRKELKKLR---KKQRALKREKEKEELEEKAEEIFEKLKKGEKlttEELKLLQKS 293
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 495-863 4.06e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 51.27  E-value: 4.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   495 HFQGSGDMMSFLMteaRQHNTEIRMAVNKVADKMDHLmtkvEELQKHSSGNSMLLPSMSvtmetsmiMSNIQRIIQENER 574
Cdd:pfam15921  214 HFRSLGSAISKIL---RELDTEISYLKGRIFPVEDQL----EALKSESQNKIELLLQQH--------QDRIEQLISEHEV 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   575 LKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENtqariLHAEQEKAKVTEElaaatAQVSHLQ 654
Cdd:pfam15921  279 EITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQ-----LRSELREAKRMYE-----DKIEELE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   655 LKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADL----SELREASEQTQTKFKSEKQS-------RRQLE---LKV 720
Cdd:pfam15921  349 KQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLhkreKELSLEKEQNKRLWDRDTGNsitidhlRRELDdrnMEV 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   721 TSLEEELTDLRAE-KTSLEKNLS--ERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQllKKARVSTDQAAAEQLTLAQA 797
Cdd:pfam15921  429 QRLEALLKAMKSEcQGQMERQMAaiQGKNESLEKVSSLTAQLESTKEMLRKVVEELTA--KKMTLESSERTVSDLTASLQ 506

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926925   798 ELQSQWEAKCEQL--LASARDEHLQQYREVCAQRDAHQQklalLQDECLALQAQIAA-------FTEQKEHMQRL 863
Cdd:pfam15921  507 EKERAIEATNAEItkLRSRVDLKLQELQHLKNEGDHLRN----VQTECEALKLQMAEkdkvieiLRQQIENMTQL 577
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 565-865 4.29e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 4.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   565 IQRIIQENERLKQ---ELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTE 641
Cdd:TIGR00618  565 MQEIQQSFSILTQcdnRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALK 644

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   642 ELAAATAQVSHLQLKMTAHQKKETELQLQLTD-NLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKV 720
Cdd:TIGR00618  645 LTALHALQLTLTQERVREHALSIRVLPKELLAsRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   721 TSLEEELTDLRAEKTSLEKNLSERKKKsAQERCQAEAEMDEiRKSHQE-----ELDRLRQLLKKARVSTDQAAAEQLTLA 795
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMHQ-ARTVLKARTEAHF-NNNEEVtaalqTGAELSHLAAEIQFFNRLREEDTHLLK 802

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   796 QAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDA------HQQKLALLQD-ECLALQAQiaAFTEQKEHMQRLEK 865
Cdd:TIGR00618  803 TLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEeksatlGEITHQLLKYeECSKQLAQ--LTQEQAKIIQLSDK 877
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
569-868 4.53e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 4.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  569 IQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQsnlmmEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATA 648
Cdd:PRK02224  470 IEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-----EDRIERLEERREDLEELIAERRETIEEKRERAEELRE 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  649 QVSHLQLKMTAHQKKETELQLqltdnlkETDLLRGHVTRLQADLSELreaseqtqtkfkseKQSRRQLElKVTSLEEELT 728
Cdd:PRK02224  545 RAAELEAEAEEKREAAAEAEE-------EAEEAREEVAELNSKLAEL--------------KERIESLE-RIRTLLAAIA 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  729 DLRAEKTSLeknlserkkksaQERCQAEAEMDEIRKSHQEEL-DRLRQL---LKKARVSTDQAAAEQLTLAQAELqsqwe 804
Cdd:PRK02224  603 DAEDEIERL------------REKREALAELNDERRERLAEKrERKRELeaeFDEARIEEAREDKERAEEYLEQV----- 665

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926925  805 akceqllasarDEHLQQYREvcaQRDAhqqklalLQDECLALQAQIAAFTEQKEHMQRLEKTKS 868
Cdd:PRK02224  666 -----------EEKLDELRE---ERDD-------LQAEIGAVENELEELEELRERREALENRVE 708
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
565-803 4.86e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 4.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  565 IQRIIQENERLKQELLEKSS-----RIEEQNDKISDLIERNQRYVEQSNLMmekrnnSLQTATENTQARILHAEQEKAKV 639
Cdd:COG3206   158 AEAYLEQNLELRREEARKALefleeQLPELRKELEEAEAALEEFRQKNGLV------DLSEEAKLLLQQLSELESQLAEA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  640 TEELAAATAQVSHLQlkmtahqkKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASE----------QTQTKFKS- 708
Cdd:COG3206   232 RAELAEAEARLAALR--------AQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSArytpnhpdviALRAQIAAl 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  709 EKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERcQAEAEMDEIrkshQEELDRLRQLLKKArvstdQAA 788
Cdd:COG3206   304 RAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELP-ELEAELRRL----EREVEVARELYESL-----LQR 373

                         250
                  ....*....|....*
gi 568926925  789 AEQLTLAQAELQSQW 803
Cdd:COG3206   374 LEEARLAEALTVGNV 388
COG5022 COG5022
Myosin heavy chain [General function prediction only];
521-734 5.02e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 51.23  E-value: 5.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  521 VNKVADKMDHLMTKVEELQKHSSGNSML---LPSMSVTMETSM---IMSNIQRIIQ-ENERLKQELLEKSSRIEEQNDKI 593
Cdd:COG5022   894 ISSLKLVNLELESEIIELKKSLSSDLIEnleFKTELIARLKKLlnnIDLEEGPSIEyVKLPELNKLHEVESKLKETSEEY 973

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  594 SDLIERNQRYVEQSNLMMEKRNNSLQTATE-NTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLT 672
Cdd:COG5022   974 EDLLKKSTILVREGNKANSELKNFKKELAElSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQKLKG 1053

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926925  673 DNLKEtdllrghVTRLQADLSELREASEQTQTKFKSEKQSRRQ--LELKVTSLEEELTDLRAEK 734
Cdd:COG5022  1054 LLLLE-------NNQLQARYKALKLRRENSLLDDKQLYQLESTenLLKTINVKDLEVTNRNLVK 1110
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 648-857 7.70e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 50.24  E-value: 7.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   648 AQVSHLQLKMTAHQKKETELQLQLtdnlketDLLRGHVTRLQADLSELREASEQTQTKFKS-------EKQSRRQLELKv 720
Cdd:pfam09726  402 QDIKKLKAELQASRQTEQELRSQI-------SSLTSLERSLKSELGQLRQENDLLQTKLHNavsakqkDKQTVQQLEKR- 473

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   721 tsLEEEltdlRAEKTSLEKNLSERKK-------KSAQERCQAEA---EMDEIRKSHQEELD-RLRQLLKKARVSTDQAAa 789
Cdd:pfam09726  474 --LKAE----QEARASAEKQLAEEKKrkkeeeaTAARAVALAAAsrgECTESLKQRKRELEsEIKKLTHDIKLKEEQIR- 546

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925   790 eqltlaqaelqsQWEAKCEQllasardehLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQK 857
Cdd:pfam09726  547 ------------ELEIKVQE---------LRKYKESEKDTEVLMSALSAMQDKNQHLENSLSAETRIK 593
mukB PRK04863
chromosome partition protein MukB;
641-881 9.55e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.34  E-value: 9.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  641 EELAAATAQVSHLQLKMTAHQKKETELQLQLtDNLKET-DLLRGHVTR--------LQADLSELREASEQTQTKFKSEKQ 711
Cdd:PRK04863  837 AELRQLNRRRVELERALADHESQEQQQRSQL-EQAKEGlSALNRLLPRlnlladetLADRVEEIREQLDEAEEAKRFVQQ 915

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  712 SRRQLELkvtsLEEELTDLRAEktsleknlserkkksaqercqaEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAA--- 788
Cdd:PRK04863  916 HGNALAQ----LEPIVSVLQSD----------------------PEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQrra 969

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  789 ------AEQLTLAQAELQSQWEAKCEQlLASARDEHLQQYREVCAQrdaHQQKLALLQDeclaLQAQIAAFTEQ-KEHMQ 861
Cdd:PRK04863  970 hfsyedAAEMLAKNSDLNEKLRQRLEQ-AEQERTRAREQLRQAQAQ---LAQYNQVLAS----LKSSYDAKRQMlQELKQ 1041

                         250       260
                  ....*....|....*....|...
gi 568926925  862 RLEKTKSQAPAG---RAAADPSE 881
Cdd:PRK04863 1042 ELQDLGVPADSGaeeRARARRDE 1064
PRK11281 PRK11281
mechanosensitive channel MscK;
564-800 1.31e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 49.91  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  564 NIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERN-----QRYVEQSNLMMEKRNNSLQTATENTQarilhaeqekak 638
Cdd:PRK11281   74 KIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNdeetrETLSTLSLRQLESRLAQTLDQLQNAQ------------ 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 vtEELAAATAQVSHLQLK-------MTAHQKKETELQLQLTDNLKETDLLRG-HVTRLQADLS------ELREASEQTQT 704
Cdd:PRK11281  142 --NDLAEYNSQLVSLQTQperaqaaLYANSQRLQQIRNLLKGGKVGGKALRPsQRVLLQAEQAllnaqnDLQRKSLEGNT 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  705 KFKSEKQSRRQL-ELKVTSLEEELTDLRAEKTslEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVS 783
Cdd:PRK11281  220 QLQDLLQKQRDYlTARIQRLEHQLQLLQEAIN--SKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRLLKA 297

                         250
                  ....*....|....*..
gi 568926925  784 TDQAAaeqlTLAQAELQ 800
Cdd:PRK11281  298 TEKLN----TLTQQNLR 310
CAGE1 pfam15066
Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...
 573-752 1.51e-05

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.


Pssm-ID: 464481  Cd Length: 528  Bit Score: 49.06  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   573 ERLKQELLEKSSR-------IEEQNDKISDLIErnqryvEQSNLMMEKR--NNSLQTATE---NTQARILHAEQEKAKVT 640
Cdd:pfam15066  345 EKKVKELQMKITKqqvfvdiINKLKENVEELIE------DKYNVILEKNdiNKTLQNLQEilaNTQKHLQESRKEKETLQ 418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   641 EELAAATAQVSHLQLK-MTAHQKKETE----LQLQLTDNLKEtdllrGHVTRLQADLSELREASEQTQTKFKSEKQSRRQ 715
Cdd:pfam15066  419 LELKKIKVNYVHLQERyITEMQQKNKSvsqcLEMDKTLSKKE-----EEVERLQQLKGELEKATTSALDLLKREKETREQ 493

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 568926925   716 LELkvtSLEEELTdlRAEKtsleKNLSERKK-KSAQER 752
Cdd:pfam15066  494 EFL---SLQEEFQ--KHEK----ENLEERQKlKSRLEK 522
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
641-824 1.56e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  641 EELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTrlqaDLSELREASEQTQtKFKSEKQSRRQLELKV 720
Cdd:COG4717   337 EELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVE----DEEELRAALEQAE-EYQELKEELEELEEQL 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  721 TSLEEELTDLRAEKTslEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQ 800
Cdd:COG4717   412 EELLGELEELLEALD--EEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELA 489

                         170       180
                  ....*....|....*....|....
gi 568926925  801 SQWEAKceQLLASARDEHLQQYRE 824
Cdd:COG4717   490 EEWAAL--KLALELLEEAREEYRE 511
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 571-871 1.72e-05

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 49.26  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   571 ENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLmmekrnnslqtATENTQARILHAEQEKAKVTEEL-AAATAQ 649
Cdd:pfam05667  223 EEEWNSQGLASRLTPEEYRKRKRTKLLKRIAEQLRSAAL-----------AGTEATSGASRSAQDLAELLSSFsGSSTTD 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   650 VSHLQLKMTAHQKKET---ELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEE 726
Cdd:pfam05667  292 TGLTKGSRFTHTEKLQftnEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   727 LTDLRAEKTSLEKNLsERKKKSAQERCQAEAEMDEirkshqeeldrLRQLLkkarvstdQAAAEQLtlaqAELQSQWEAK 806
Cdd:pfam05667  372 LEELKEQNEELEKQY-KVKKKTLDLLPDAEENIAK-----------LQALV--------DASAQRL----VELAGQWEKH 427

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   807 CEQLLasardEHLQQYREVCA-QRDAHQQKLA---LLQDECLalqaQIAAFTEQKEHMQR-LEKTKSQAP 871
Cdd:pfam05667  428 RVPLI-----EEYRALKEAKSnKEDESQRKLEeikELREKIK----EVAEEAKQKEELYKqLVAEYERLP 488
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 641-904 1.87e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  641 EELAAATAQVSHLQLKMTAHQKKETELQLQLtDNLKET-DLLR---GHVTRL-QADLSELREASEQTQTKFKSEKQSRRQ 715
Cdd:COG3096   836 AELAALRQRRSELERELAQHRAQEQQLRQQL-DQLKEQlQLLNkllPQANLLaDETLADRLEELREELDAAQEAQAFIQQ 914

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  716 LELKVTSLEEELTDLRAEKTS---LEKNLSERKKKSAQERCQAEAeMDEI--RKSH-------------QEELDRLRQLL 777
Cdd:COG3096   915 HGKALAQLEPLVAVLQSDPEQfeqLQADYLQAKEQQRRLKQQIFA-LSEVvqRRPHfsyedavgllgenSDLNEKLRARL 993

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  778 KKArvstdQAAAEQLTLAQAELQSQWeAKCEQLLASARdehlqqyrevcAQRDAHQQKLALLQDECLALQAQIAAFTEQK 857
Cdd:COG3096   994 EQA-----EEARREAREQLRQAQAQY-SQYNQVLASLK-----------SSRDAKQQTLQELEQELEELGVQADAEAEER 1056

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 568926925  858 --EHMQRLEktkSQAPAGRAAADPSEKVKKIMNQVFQSLRGEF-ELEESY 904
Cdd:COG3096  1057 arIRRDELH---EELSQNRSRRSQLEKQLTRCEAEMDSLQKRLrKAERDY 1103
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 573-848 1.88e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  573 ERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMmEKRNNSL-------QTATENTQARILHAEQ-----EKAK-- 638
Cdd:COG3096   350 ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAA-EEEVDSLksqladyQQALDVQQTRAIQYQQavqalEKARal 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 ----------VTEELAA-------ATAQVSHLQLKMT----AHQKKETELQL------------------QLTDNLKETD 679
Cdd:COG3096   429 cglpdltpenAEDYLAAfrakeqqATEEVLELEQKLSvadaARRQFEKAYELvckiageversqawqtarELLRRYRSQQ 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  680 LLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSlEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEM 759
Cdd:COG3096   509 ALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDA-AEELEELLAELEAQLEELEEQAAEAVEQRSELRQQL 587

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  760 DEIRKshqeeldRLRQLLKKARV-STDQAAAEQLtlaqaELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLAL 838
Cdd:COG3096   588 EQLRA-------RIKELAARAPAwLAAQDALERL-----REQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQA 655

                         330
                  ....*....|
gi 568926925  839 LQDECLALQA 848
Cdd:COG3096   656 LESQIERLSQ 665
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 569-867 2.13e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.20  E-value: 2.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   569 IQENERLKqELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTatentqarilhaeqekakvtEELAAATA 648
Cdd:pfam02463  169 RKKKEALK-KLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKL--------------------ELEEEYLL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   649 QVSHLQLkmtaHQKKETELQLQLTDNLKETDLLRGhvtrlqadLSELREASEQTQTKFKSEkqsrrqlELKVTSLEEE-- 726
Cdd:pfam02463  228 YLDYLKL----NEERIDLLQELLRDEQEEIESSKQ--------EIEKEEEKLAQVLKENKE-------EEKEKKLQEEel 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   727 -LTDLRAEKTSLEKNLSERKKKSAQErcQAEAEMDEIRKsHQEELDRLRQLLKKARVS-TDQAAAEQLTLAQAELQSQWE 804
Cdd:pfam02463  289 kLLAKEEEELKSELLKLERRKVDDEE--KLKESEKEKKK-AEKELKKEKEEIEELEKElKELEIKREAEEEEEEELEKLQ 365

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926925   805 AKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFtEQKEHMQRLEKTK 867
Cdd:pfam02463  366 EKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELA-RQLEDLLKEEKKE 427
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 643-880 2.89e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  643 LAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTkfksekqsrrqlelKVTS 722
Cdd:COG3883     4 LALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQA--------------EIDK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  723 LEEELTDLRAEKTSLEKNLSERkKKSAQERCQAEAEMDEI--RKSHQEELDRLrQLLKKArVSTDQAAAEQLTLAQAELQ 800
Cdd:COG3883    70 LQAEIAEAEAEIEERREELGER-ARALYRSGGSVSYLDVLlgSESFSDFLDRL-SALSKI-ADADADLLEELKADKAELE 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  801 SQWEAKCEQL--LASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAAD 878
Cdd:COG3883   147 AKKAELEAKLaeLEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAA 226


                  ..
gi 568926925  879 PS 880
Cdd:COG3883   227 AA 228
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 561-820 2.92e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.80  E-value: 2.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKI---SDLIERNQRYVEQSNLMMEKRNNSLqtaTENTQARILHAEQEKA 637
Cdd:COG3096   925 LVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDAVGLLGENSDL---NEKLRARLEQAEEARR 1001

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  638 KVTEELAAATAQV-----------SHLQLKMTAHQKKETELQ---LQLTDNLKETdlLRGHVTRLQADLSELReaseqtq 703
Cdd:COG3096  1002 EAREQLRQAQAQYsqynqvlaslkSSRDAKQQTLQELEQELEelgVQADAEAEER--ARIRRDELHEELSQNR------- 1072

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  704 tkfksekqSRRqlelkvTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEaemdeirkSHQEELDRLRQLLKKARVS 783
Cdd:COG3096  1073 --------SRR------SQLEKQLTRCEAEMDSLQKRLRKAERDYKQEREQVV--------QAKAGWCAVLRLARDNDVE 1130

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 568926925  784 TDQAAAEQLTLAQAELQSQWEAKCEQL-LASARDEHLQ 820
Cdd:COG3096  1131 RRLHRRELAYLSADELRSMSDKALGALrLAVADNEHLR 1168
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 576-896 3.15e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.41  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  576 KQELLEKSSRIEEQNDKISDLIERnQRYVEQSNLMMEKRNNSLQTATENtQARILHAEQEKAKVTEELAAATAQVSHLQL 655
Cdd:COG3096   298 RRQLAEEQYRLVEMARELEELSAR-ESDLEQDYQAASDHLNLVQTALRQ-QEKIERYQEDLEELTERLEEQEEVVEEAAE 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  656 kmtahQKKETELQLQLTDnlKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQL---ELKVTSLEEELTDLRA 732
Cdd:COG3096   376 -----QLAEAEARLEAAE--EEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKARALCglpDLTPENAEDYLAAFRA 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  733 EKTSLEKNLSERKKK---SAQERCQAEAEMDEIRK-----SHQEELDRLRQLLKKARvsTDQAAAEQLT-----LAQAE- 798
Cdd:COG3096   449 KEQQATEEVLELEQKlsvADAARRQFEKAYELVCKiagevERSQAWQTARELLRRYR--SQQALAQRLQqlraqLAELEq 526

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  799 -LQSQWEAK-------------------CEQLLASA---RDEHLQQYREVCAQRDAHQQKLAllqdeclALQAQIAAFTe 855
Cdd:COG3096   527 rLRQQQNAErlleefcqrigqqldaaeeLEELLAELeaqLEELEEQAAEAVEQRSELRQQLE-------QLRARIKELA- 598

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 568926925  856 qkehmqrlektkSQAPAGRAAADPSEKVKKIMNQVFQSLRG 896
Cdd:COG3096   599 ------------ARAPAWLAAQDALERLREQSGEALADSQE 627
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 630-821 3.66e-05

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 48.21  E-value: 3.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   630 LHAEQEKAKVTE--ELAAATAQVSHLQLKmtahqKKETELQLQLT-DNLKETDLLRGHVTRLQADLSELreaSEQTQTKF 706
Cdd:pfam09731  236 EKAQSLAKLVDQykELVASERIVFQQELV-----SIFPDIIPVLKeDNLLSNDDLNSLIAHAHREIDQL---SKKLAELK 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   707 KSEKQsrrQLELKVTSLEEELTDLRAEktsLEKNLSE-RKKKSAQERCQAEAEMDEIRKSHQEEldrLRQLLKKARVSTD 785
Cdd:pfam09731  308 KREEK---HIERALEKQKEELDKLAEE---LSARLEEvRAADEAQLRLEFEREREEIRESYEEK---LRTELERQAEAHE 378

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 568926925   786 QAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQ 821
Cdd:pfam09731  379 EHLKDVLVEQEIELQREFLQDIKEKVEEERAGRLLK 414
46 PHA02562
endonuclease subunit; Provisional
 509-747 4.03e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.70  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  509 EARQHNTEIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMetsmiMSNIQRIIQENERLKQELLEKSSRIEE 588
Cdd:PHA02562  178 ELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDEL-----VEEAKTIKAEIEELTDELLNLVMDIED 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  589 QNDKISDLierNQRYVEQSNLM--------MEKRNNSLQTATENtqariLHAEQEK-AKVTEELAAATAQVShlqlKMTA 659
Cdd:PHA02562  253 PSAALNKL---NTAAAKIKSKIeqfqkvikMYEKGGVCPTCTQQ-----ISEGPDRiTKIKDKLKELQHSLE----KLDT 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  660 HQKKETELQLQLTDNLKEtdllrghVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEK 739
Cdd:PHA02562  321 AIDELEEIMDEFNEQSKK-------LLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVK 393


                  ....*...
gi 568926925  740 NLSERKKK 747
Cdd:PHA02562  394 TKSELVKE 401
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 656-801 4.12e-05

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 46.05  E-value: 4.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   656 KMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQtqtkFKSEKQSRRQLELKVTSLEEELTDLRAEKt 735
Cdd:pfam13851   34 EIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLEN----YEKDKQSLKNLKARLKVLEKELKDLKWEH- 108

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925   736 sleKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKaRVstdQAAAEQLTLAQAELQS 801
Cdd:pfam13851  109 ---EVLEQRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEK-KL---QALGETLEKKEAQLNE 167
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 561-817 4.18e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 48.30  E-value: 4.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   561 IMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIER-NQRYVEQSNLMMEKR-------NNSLQTATENTQARILHA 632
Cdd:pfam12128  267 YKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDElNGELSAADAAVAKDRselealeDQHGAFLDADIETAAADQ 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   633 EQ------EKAKVTEELAAATAQVSHLQLKMTA-HQKKETELQLQLTDNLKETDLLRGHVTR--------LQADLSELRE 697
Cdd:pfam12128  347 EQlpswqsELENLEERLKALTGKHQDVTAKYNRrRSKIKEQNNRDIAGIKDKLAKIREARDRqlavaeddLQALESELRE 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   698 ASEQTQTKFKSEKQ--SRRQLELK-----VTSLEEELTDLRAEKTSLEknlserKKKSAQERCQAEAEmdeirkSHQEEL 770
Cdd:pfam12128  427 QLEAGKLEFNEEEYrlKSRLGELKlrlnqATATPELLLQLENFDERIE------RAREEQEAANAEVE------RLQSEL 494

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 568926925   771 DRLRQLLKKARVSTDQA--AAEQLTLAQAELQSQWEAKCEQLLASARDE 817
Cdd:pfam12128  495 RQARKRRDQASEALRQAsrRLEERQSALDELELQLFPQAGTLLHFLRKE 543
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 632-903 4.42e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 47.72  E-value: 4.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   632 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQlqltdnlKETDLLRGHVTRLQADLSElrEASEQTQTKFKSEKQ 711
Cdd:pfam05701   61 AEAAKAQVLEELESTKRLIEELKLNLERAQTEEAQAK-------QDSELAKLRVEEMEQGIAD--EASVAAKAQLEVAKA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   712 SRRQLELKVTSLEEELTDLRAEKTSLeknLSERkKKSAQERCQAEAEMDEIRKSHQE---ELDRLRQLLKKARVSTDQAA 788
Cdd:pfam05701  132 RHAAAVAELKSVKEELESLRKEYASL---VSER-DIAIKRAEEAVSASKEIEKTVEEltiELIATKESLESAHAAHLEAE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   789 AEQLTLAQAELQ--SQWEAKCEQLlasarDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQK-----EHMQ 861
Cdd:pfam05701  208 EHRIGAALAREQdkLNWEKELKQA-----EEELQRLNQQLLSAKDLKSKLETASALLLDLKAELAAYMESKlkeeaDGEG 282

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568926925   862 RLEKTKSQAPAGRAAADPS-EKVK----------KIMNQVFQSLRGEFELEES 903
Cdd:pfam05701  283 NEKKTSTSIQAALASAKKElEEVKaniekakdevNCLRVAAASLRSELEKEKA 335
PTZ00121 PTZ00121
MAEBL; Provisional
 509-902 4.64e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 4.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  509 EARQHNTEIRM-AVNKV--ADKMDHLMTKVEELQKHSSGNSMLLPSMSVtmetsmiMSNIQRIIQENERLKQELLEKSsr 585
Cdd:PTZ00121 1216 EARKAEDAKKAeAVKKAeeAKKDAEEAKKAEEERNNEEIRKFEEARMAH-------FARRQAAIKAEEARKADELKKA-- 1286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  586 ieEQNDKISDLIERNQ-RYVEQSNLMME--KRNNSLQTATENTQ--ARILHAEQEKAKVTEELAAATAQVSHLQLKMTAH 660
Cdd:PTZ00121 1287 --EEKKKADEAKKAEEkKKADEAKKKAEeaKKADEAKKKAEEAKkkADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE 1364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  661 QKKETELQlqltdnlKETDLLRGHVTRLQADlsELREASEqtqTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKN 740
Cdd:PTZ00121 1365 KAEAAEKK-------KEEAKKKADAAKKKAE--EKKKADE---AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK 1432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  741 LSERKKKSAQERCQAEA--EMDEIRKSHQ-----EELDRLRQLLKKA----RVSTDQAAAEQLTLAQAELQSQWEA--KC 807
Cdd:PTZ00121 1433 ADEAKKKAEEAKKADEAkkKAEEAKKAEEakkkaEEAKKADEAKKKAeeakKADEAKKKAEEAKKKADEAKKAAEAkkKA 1512

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  808 EQLLASARDEHLQQYREVCAQRDAHQQKLAllQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGRAAADPSEKVKKIM 887
Cdd:PTZ00121 1513 DEAKKAEEAKKADEAKKAEEAKKADEAKKA--EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE 1590

                         410
                  ....*....|....*
gi 568926925  888 NQVFQSLRGEFELEE 902
Cdd:PTZ00121 1591 EARIEEVMKLYEEEK 1605
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 595-773 5.22e-05

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 45.31  E-value: 5.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   595 DLIERNQRYVEQSNLMmEKRNNSLQTATEN-TQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTD 673
Cdd:pfam08614    4 ELIDAYNRLLDRTALL-EAENAKLQSEPESvLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRGELAQRLVD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   674 nlketdllrghvtrLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEEL-------TDLRAEKTSLEKNLSerkk 746
Cdd:pfam08614   83 --------------LNEELQELEKKLREDERRLAALEAERAQLEEKLKDREEELrekrklnQDLQDELVALQLQLN---- 144

                          170       180
                   ....*....|....*....|....*..
gi 568926925   747 ksaqercQAEAEMDEIRKSHQEELDRL 773
Cdd:pfam08614  145 -------MAEEKLRKLEKENRELVERW 164
mukB PRK04863
chromosome partition protein MukB;
573-856 5.40e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  573 ERLKQELLEKSSRIEEQN---DKISDLIERNQRYVEQSNLMMEKRNNSL---QTATENTQARIL---HAEQ--EKAKVTE 641
Cdd:PRK04863  351 ERYQADLEELEERLEEQNevvEEADEQQEENEARAEAAEEEVDELKSQLadyQQALDVQQTRAIqyqQAVQalERAKQLC 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  642 ELAAATA-QVSHLQLKMTAHQKKETELQLQLTDNLKETD-----------LLR---GHVTR------------------- 687
Cdd:PRK04863  431 GLPDLTAdNAEDWLEEFQAKEQEATEELLSLEQKLSVAQaahsqfeqayqLVRkiaGEVSRseawdvarellrrlreqrh 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  688 -------LQADLSELREASEQTQTKFKSEKQSRRQLELKVTSlEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAemd 760
Cdd:PRK04863  511 laeqlqqLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDD-EDELEQLQEELEARLESLSESVSEARERRMALRQ--- 586

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  761 eirksHQEELD-RLRQLLKKARV-STDQAAAEQLtlaqaELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLAL 838
Cdd:PRK04863  587 -----QLEQLQaRIQRLAARAPAwLAAQDALARL-----REQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQA 656

                         330
                  ....*....|....*...
gi 568926925  839 LQDECLALQAQIAAFTEQ 856
Cdd:PRK04863  657 LDEEIERLSQPGGSEDPR 674
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 565-869 5.73e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.84  E-value: 5.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   565 IQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRyvEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELA 644
Cdd:pfam13868   78 LEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQ--AEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDE 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   645 AATAQVSHLQLKMTAHQKKETELQLQltdnlKEtdllrghvtRLQADLSELREASEQTQtkfksekqsrrqlelkvtsle 724
Cdd:pfam13868  156 RILEYLKEKAEREEEREAEREEIEEE-----KE---------REIARLRAQQEKAQDEK--------------------- 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   725 EELTDLRAEKTsLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELdRLRQLLKKARVSTDQAAAEQLTLAQAELQSQwe 804
Cdd:pfam13868  201 AERDELRAKLY-QEEQERKERQKEREEAEKKARQRQELQQAREEQI-ELKERRLAEEAEREEEEFERMLRKQAEDEEI-- 276

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   805 akcEQLLASARDEHLQQYR-EVCAQ-RDAHQQKLALLQDEclaLQAQIAAFTEQKEHMQRLEKTKSQ 869
Cdd:pfam13868  277 ---EQEEAEKRRMKRLEHRrELEKQiEEREEQRAAEREEE---LEEGERLREEEAERRERIEEERQK 337
growth_prot_Scy NF041483
polarized growth protein Scy;
571-821 6.16e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.51  E-value: 6.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  571 ENERLKQELLEKSSRIEEQNDkisDLIERNQRYVEQSNLMMEKRNNSLQTATENTqARILHAEQEKAkVTEELAAATAQV 650
Cdd:NF041483  503 ESERVRTEAIERATTLRRQAE---ETLERTRAEAERLRAEAEEQAEEVRAAAERA-ARELREETERA-IAARQAEAAEEL 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  651 SHLQlkmTAHQKKETELQLQLTDNLKETDLLRghvtrlqadlselREASEQTQtKFKSEKQSR-RQLElkvTSLEEELTD 729
Cdd:NF041483  578 TRLH---TEAEERLTAAEEALADARAEAERIR-------------REAAEETE-RLRTEAAERiRTLQ---AQAEQEAER 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  730 LRAEKTS-LEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQwEAKCE 808
Cdd:NF041483  638 LRTEAAAdASAARAEGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQEEAARR-RREAE 716

                         250
                  ....*....|...
gi 568926925  809 QLLASARDEHLQQ 821
Cdd:NF041483  717 ETLGSARAEADQE 729
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 584-802 9.09e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 9.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  584 SRIEEQNDKISDLIERNQRYVEQSNLMMEKRNnSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQ--LKMTAHQ 661
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELE-ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERReeLGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  662 KKETELQLQLTDNLKE----TDLLR---------GHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELT 728
Cdd:COG3883    95 LYRSGGSVSYLDVLLGsesfSDFLDrlsalskiaDADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926925  729 DLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQ 802
Cdd:COG3883   175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAG 248
PHA03247 PHA03247
large tegument protein UL36; Provisional
 944-1129 1.16e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  944 PLRPSLEQPGPATPGMPPAPPSGETQEAPEvlpeqvvgettPLPLQALPTPENGAQTrkgePAEAEVPSEIKDSSLPPQP 1023
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAPTTDPAGA-----------GEPSGAVPQPWLGALV----PGRVAVPRFRVPQPAPSRE 2987

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925 1024 AGIPA-HRVLGPPTSIPPKPPGPVTMDSESEEMLAADQRTVQPNgllgeEHVREVATDGLLQGNSRRLSL-TPDPEKGEP 1101
Cdd:PHA03247 2988 APASStPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPP-----DDTEDSDADSLFDSDSERSDLeALDPLPPEP 3062

                         170       180
                  ....*....|....*....|....*....
gi 568926925 1102 PalDPESQGGEAQPPECKQAEDVSSS-GP 1129
Cdd:PHA03247 3063 H--DPFAHEPDPATPEAGARESPSSQfGP 3089
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 632-743 1.16e-04

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 43.01  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   632 AEQEKAKVTEELAAATAQVSHLQLKM--------TAHQKKETELQLQlTDNLKETDLLRGHVTRLQADLSELREASEQTQ 703
Cdd:pfam07926    6 LQSEIKRLKEEAADAEAQLQKLQEDLekqaeiarEAQQNYERELVLH-AEDIKALQALREELNELKAEIAELKAEAESAK 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568926925   704 TKFKSEKQSrrqlelkvtsLEEELTDLRAEKTSLEKNLSE 743
Cdd:pfam07926   85 AELEESEES----------WEEQKKELEKELSELEKRIED 114
Tig COG0544
FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, ...
 185-250 1.19e-04

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440310 [Multi-domain]  Cd Length: 424  Bit Score: 45.89  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925  185 LVAAEGPAvETGDSLEVAYTGWllqnhVLGQVFDSTANKDKPLrlKLGSGKVVKGLEDGLLGMKKG 250
Cdd:COG0544   151 LVPVERAA-EEGDRVTIDFEGT-----IDGEEFEGGKAEDYSL--ELGSGSFIPGFEEQLVGMKAG 208
tig TIGR00115
trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first ...
 185-255 1.22e-04

trigger factor; Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY). The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity. This protein is found in a single copy in virtually every bacterial genome. [Protein fate, Protein folding and stabilization]


Pssm-ID: 272913 [Multi-domain]  Cd Length: 410  Bit Score: 46.01  E-value: 1.22e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926925   185 LVAAEGPAVETGDSLEVAYTGwllqnHVLGQVFDSTANKDkpLRLKLGSGKVVKGLEDGLLGMKKGGKRLI 255
Cdd:TIGR00115  141 LVPVERGAAEKGDRVTIDFEG-----FIDGEAFEGGKAEN--FSLELGSGQFIPGFEEQLVGMKAGEEKEI 204
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 577-778 1.26e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.58  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   577 QELLEKSSRIEEQNDKISDLIERNQRYVEQ-----------------SNLMMEKRNNSLQTATENTQAR---ILHAEQEK 636
Cdd:TIGR01612 1489 KEHIDKSKGCKDEADKNAKAIEKNKELFEQykkdvtellnkysalaiKNKFAKTKKDSEIIIKEIKDAHkkfILEAEKSE 1568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   637 AKVTE--------ELAAATAQVSH-----LQLKMTAHQKKE---TELQLQLTDNLKETDLLRGHVTRLQAD-----LSEL 695
Cdd:TIGR01612 1569 QKIKEikkekfriEDDAAKNDKSNkaaidIQLSLENFENKFlkiSDIKKKINDCLKETESIEKKISSFSIDsqdteLKEN 1648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   696 REASEQTQTKFKSEKQSRRQLELKVTsleeELTDLRAEKTSLEKNLSERKKKsaQERCQAEaEMDEIRKSHQEELDRLRQ 775
Cdd:TIGR01612 1649 GDNLNSLQEFLESLKDQKKNIEDKKK----ELDELDSEIEKIEIDVDQHKKN--YEIGIIE-KIKEIAIANKEEIESIKE 1721


                   ...
gi 568926925   776 LLK 778
Cdd:TIGR01612 1722 LIE 1724
PTZ00121 PTZ00121
MAEBL; Provisional
 570-772 1.33e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  570 QENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQsnlmmekrnnsLQTATENTQARilhAEQEKAKVTEELAAATaq 649
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE-----------LKKAEEENKIK---AAEEAKKAEEDKKKAE-- 1678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  650 vshlQLKMTAHQKKETELQLQL-TDNLKETDLLRGHVTRLQADLSELREASEQT-----QTKFKSEKQSRRQLELKVtsl 723
Cdd:PTZ00121 1679 ----EAKKAEEDEKKAAEALKKeAEEAKKAEELKKKEAEEKKKAEELKKAEEENkikaeEAKKEAEEDKKKAEEAKK--- 1751

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568926925  724 EEEltdlraEKTSLEKNLSERKKKSAQERCQAEA----EMDEIRKSHQEELDR 772
Cdd:PTZ00121 1752 DEE------EKKKIAHLKKEEEKKAEEIRKEKEAvieeELDEEDEKRRMEVDK 1798
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 518-868 1.45e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 46.35  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   518 RMAVNK-----VADKMDHLMTKVEELQK----HSSGNSMLLPSMSVT------METSMIMS--NIQRIIQENERLKQE-- 578
Cdd:pfam10174   54 RISVLKeqyrvTQEENQHLQLTIQALQDelraQRDLNQLLQQDFTTSpvdgedKFSTPELTeeNFRRLQSEHERQAKElf 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   579 LLEKS-----SRIEEQndkisdliernqryvEQSnlmMEKRNNSLQTATENTQARIL--HAEQEKAKVTEELAAATAQVS 651
Cdd:pfam10174  134 LLRKTleemeLRIETQ---------------KQT---LGARDESIKKLLEMLQSKGLpkKSGEEDWERTRRIAEAEMQLG 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   652 HLQLKMtahQKKETELQlqltdNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLeeeltdlr 731
Cdd:pfam10174  196 HLEVLL---DQKEKENI-----HLREELHRRNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQML-------- 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   732 aeKTSLEKNLSERkkksaqercQAEAEMDEIRKSH----QEELDRLRQLL--KKARVSTDQAAAEQLTLAQAElqsqwea 805
Cdd:pfam10174  260 --KTNGLLHTEDR---------EEEIKQMEVYKSHskfmKNKIDQLKQELskKESELLALQTKLETLTNQNSD------- 321

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   806 kCEQllasardeHLQQYREVCAqrdAHQQKLALLQDECLALQAQI----AAFTEQKEHMQRLEKTKS 868
Cdd:pfam10174  322 -CKQ--------HIEVLKESLT---AKEQRAAILQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKS 376
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 557-821 1.46e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 45.68  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   557 ETSMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKIsdlIERNQRYVEQSNLMMEKRNnslqtatentqARILHAEQEK 636
Cdd:pfam13868   99 EREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEF---NEEQAEWKELEKEEEREED-----------ERILEYLKEK 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   637 AKVTEELAaatAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRghVTRLQADLSE-----LREASEQTQTKFKSEKQ 711
Cdd:pfam13868  165 AEREEERE---AEREEIEEEKEREIARLRAQQEKAQDEKAERDELR--AKLYQEEQERkerqkEREEAEKKARQRQELQQ 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   712 SRR-QLELKVTSLEEELTDLRAEKtslEKNLSERKKKSAQERCQAEAEMdEIRKSHQEELDRLRQLLKKARvstdqAAAE 790
Cdd:pfam13868  240 AREeQIELKERRLAEEAEREEEEF---ERMLRKQAEDEEIEQEEAEKRR-MKRLEHRRELEKQIEEREEQR-----AAER 310

                          250       260       270
                   ....*....|....*....|....*....|.
gi 568926925   791 QLTLAQAELQSQWEAKCEQLLASARDEHLQQ 821
Cdd:pfam13868  311 EEELEEGERLREEEAERRERIEEERQKKLKE 341
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
615-816 1.60e-04

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 46.00  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  615 NNSLQTATENTQA---RILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQAD 691
Cdd:COG5283    13 KSALESAKQRVAAlaqALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDTRQLSAAQRRLRSS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  692 LSELREASEQTQTKFKSEKQSRRQLelkvTSLEEELTDLRAEKTSLEkNLSERKKKSAQERCQAEAEMDEIRKSHQ---- 767
Cdd:COG5283    93 LEQTNRQLERQQQRLARLGARQDRL----KAARARLQRLAGAGAAAA-AIGAALAASVKPAIDFEDAMADVAATVDldks 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926925  768 -EELDRLRQLLKKA----RVSTDQAAAEQLTLAQAELQSQweakceQLLASARD 816
Cdd:COG5283   168 sEQFKALGKQARELsaqtPQSADDIAAGQAALAQAGVSAE------DILAFTPT 215
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 619-805 1.74e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  619 QTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSE---- 694
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  695 -----------------------------LREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERK 745
Cdd:COG3883    95 lyrsggsvsyldvllgsesfsdfldrlsaLSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  746 KKSAQERcQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQWEA 805
Cdd:COG3883   175 AQQAEQE-ALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 717-865 1.84e-04

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 43.74  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   717 ELKVTSLEEELTDL--RAEKTSLE----KNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARvSTDQAAAE 790
Cdd:pfam15619   10 LHKIKELQNELAELqsKLEELRKEnrllKRLQKRQEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQ-EKERDLER 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926925   791 QLTLAQAELQSQwEAKCEQLLASARDEHLqqyrevcAQRDAHQQKLALLQDEclaLQaqiaaftEQKEHMQRLEK 865
Cdd:pfam15619   89 KLKEKEAELLRL-RDQLKRLEKLSEDKNL-------AEREELQKKLEQLEAK---LE-------DKDEKIQDLER 145
mukB PRK04863
chromosome partition protein MukB;
505-906 2.05e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.72  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  505 FLMTearqHNTEIRMAVNKVADKMDHLMTKVEELqKHSSGNSMLLPSMsVTMETSMIMSNIQRIiqENER---------L 575
Cdd:PRK04863  220 YLLP----ENSGVRKAFQDMEAALRENRMTLEAI-RVTQSDRDLFKHL-ITESTNYVAADYMRH--ANERrvhleealeL 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  576 KQELLE-KSSRIEEQNDKIS-----DLIERNQRYVEQSNLMMEKRNNSLQTAtENTQARILHAEQEKAKVTEELAAATAQ 649
Cdd:PRK04863  292 RRELYTsRRQLAAEQYRLVEmarelAELNEAESDLEQDYQAASDHLNLVQTA-LRQQEKIERYQADLEELEERLEEQNEV 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  650 VShlqlkmTAHQKKEtELQLQLTDNLKETDllrghvtRLQADLSELREASEQTQTKFKSEKQSRRQLE----------LK 719
Cdd:PRK04863  371 VE------EADEQQE-ENEARAEAAEEEVD-------ELKSQLADYQQALDVQQTRAIQYQQAVQALErakqlcglpdLT 436

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  720 VTSLEEELTDLRA-EKTSLEKNLS-ERKKKSAQE-RCQAEAEMDEIRK-----SHQEELDRLRQLLKKARvsTDQAAAEQ 791
Cdd:PRK04863  437 ADNAEDWLEEFQAkEQEATEELLSlEQKLSVAQAaHSQFEQAYQLVRKiagevSRSEAWDVARELLRRLR--EQRHLAEQ 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  792 LT-----LAQAELQSQWEAKCEQLLASARDEHLQQYR---EVCAQRDAHQQKLALLQDECLALQAQ-IAAFTEQKEHMQR 862
Cdd:PRK04863  515 LQqlrmrLSELEQRLRQQQRAERLLAEFCKRLGKNLDdedELEQLQEELEARLESLSESVSEARERrMALRQQLEQLQAR 594

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  863 LEKTKSQAPAGRAAADPSEKV-----------KKIMNQVFQSLRGEFELEESYDG 906
Cdd:PRK04863  595 IQRLAARAPAWLAAQDALARLreqsgeefedsQDVTEYMQQLLERERELTVERDE 649
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 515-785 2.08e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.27  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   515 TEIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSMIMS--NIQRIiQENERLKQELLEKSSRIEEQNDK 592
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRaaHEARI-RELEEDIKTLTQRVLERETELER 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   593 ISDLIER--NQRYVEQSnlmmEKRNnsLQTATENTQA--RILHAEQEKAKVTEELAAATAQ-----VSHLQLKMTAHQKK 663
Cdd:pfam07888  155 MKERAKKagAQRKEEEA----ERKQ--LQAKLQQTEEelRSLSKEFQELRNSLAQRDTQVLqlqdtITTLTQKLTTAHRK 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   664 ETELQLQLTD--NLKE--------TDLLRG----------------HVTRLQA-----DLSELREASEQTQTKFKSEKQS 712
Cdd:pfam07888  229 EAENEALLEElrSLQErlnaserkVEGLGEelssmaaqrdrtqaelHQARLQAaqltlQLADASLALREGRARWAQERET 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   713 RRQ-----------LELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKS--------------HQ 767
Cdd:pfam07888  309 LQQsaeadkdriekLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASlrvaqkekeqlqaeKQ 388

                          330
                   ....*....|....*...
gi 568926925   768 EELDRLRQLLKKARVSTD 785
Cdd:pfam07888  389 ELLEYIRQLEQRLETVAD 406
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 679-779 2.31e-04

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 42.99  E-value: 2.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   679 DLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQ----LELKVTSLEEELTDLRAEKTSLE---KNLSERKKKSAQE 751
Cdd:pfam09744   39 ESLASRNQEHNVELEELREDNEQLETQYEREKALRKRaeeeLEEIEDQWEQETKDLLSQVESLEeenRRLEADHVSRLEE 118

                           90       100
                   ....*....|....*....|....*...
gi 568926925   752 RcqaEAEMDEIRKSHQEeldRLRQLLKK 779
Cdd:pfam09744  119 K---EAELKKEYSKLHE---RETEVLRK 140
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 566-805 2.45e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 44.75  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   566 QRIIQENERLKQELLEKSSRieeqndkisdliernqryveqsnlmmekrnNSLQTATENTqARILHAEQEKAKVTEELAA 645
Cdd:pfam09787   17 ARILQSKEKLIASLKEGSGV------------------------------EGLDSSTALT-LELEELRQERDLLREEIQK 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   646 ATAQVSHLQlkmtahqkkeTELQlqltdnlkETDllrghvTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEE 725
Cdd:pfam09787   66 LRGQIQQLR----------TELQ--------ELE------AQQQEEAESSREQLQELEEQLATERSARREAEAELERLQE 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   726 ELTDLRAEKtsleknlsERKKKSAQERCQaeaemdeirkSHQEELDRLR-QLLKKARVSTDQAAAE----QLTLAQAELQ 800
Cdd:pfam09787  122 ELRYLEEEL--------RRSKATLQSRIK----------DREAEIEKLRnQLTSKSQSSSSQSELEnrlhQLTETLIQKQ 183


                   ....*
gi 568926925   801 SQWEA 805
Cdd:pfam09787  184 TMLEA 188
PLC-beta_C pfam08703
PLC-beta C terminal; This domain corresponds to the alpha helical C terminal domain of ...
 687-826 2.46e-04

PLC-beta C terminal; This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.


Pssm-ID: 462571 [Multi-domain]  Cd Length: 176  Bit Score: 43.13  E-value: 2.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   687 RLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEM------- 759
Cdd:pfam08703    9 RLEQELLELREEQYEQEKKRKEQHLTEQIQKLKELAREKQAAELKALKESSESEKKEMKKKLERKRLESIQEAkkrtsdk 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   760 -------DEIRKSH-QEELDRLRQL----------LKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARdEHLQQ 821
Cdd:pfam08703   89 aaqerlkKEINNSHiQEVVQSIKQLeekqkrrqekLEEKQAECLQQIKEEEPQLQAELNAEYEEKLKGLPAEVR-ESVKS 167


                   ....*
gi 568926925   822 YREVC 826
Cdd:pfam08703  168 CLKEG 172
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 563-751 2.86e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 2.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   563 SNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNL---------------MMEKRNN----------- 616
Cdd:TIGR02169  304 ASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKrrdklteeyaelkeeLEDLRAEleevdkefaet 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   617 -----SLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQAD 691
Cdd:TIGR02169  384 rdelkDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   692 LSELREASEQTQTKFksekqsrRQLELKVTSLEEELTDLRAEKTSLEKnlSERKKKSAQE 751
Cdd:TIGR02169  464 LSKYEQELYDLKEEY-------DRVEKELSKLQRELAEAEAQARASEE--RVRGGRAVEE 514
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 601-824 3.02e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.17  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   601 QRYVEQSNLmmeKRNNSLQTATENtQARILHAEQEKAKVTEELAAATaqvshlQLKMTAHQKKEtELQLQLTDNLKETDL 680
Cdd:pfam01576  811 QRELEEARA---SRDEILAQSKES-EKKLKNLEAELLQLQEDLAASE------RARRQAQQERD-ELADEIASGASGKSA 879

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   681 LRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTdlrAEKTSLEKNLS-----ERKKKSAQERCQa 755
Cdd:pfam01576  880 LQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELA---AERSTSQKSESarqqlERQNKELKAKLQ- 955

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926925   756 eaEMD-EIRKSHQEELDRLRQLLKKARVSTDQAAAEQltLAQAELQSQWEAKCEQLLASARDE--HLQQYRE 824
Cdd:pfam01576  956 --EMEgTVKSKFKSSIAALEAKIAQLEEQLEQESRER--QAANKLVRRTEKKLKEVLLQVEDErrHADQYKD 1023
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 521-769 3.33e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.21  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  521 VNKVADKMDHLMTKVEELQ----KHSSGNSMLLPSMSVTMETSMIMSNIQ--------------RIIQENERL------K 576
Cdd:PTZ00440 2317 VKLYIENITHLLNRINTLIndldNYQDENYGKDKNIELNNENNSYIIKTKekinnlkeefskllKNIKRNNTLcnnnniK 2396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  577 QELLEKSSRIEEQNDKISDLIERNQRYV-------EQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQ 649
Cdd:PTZ00440 2397 DFISNIGKSVETIKQRFSSNLPEKEKLHqieenlnEIKNIMNETKRISNVDAFTNKILQDIDNEKNKENNNMNAEKIDDL 2476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  650 VSHLqlkmTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQS-RRQLELKVTSLEE--- 725
Cdd:PTZ00440 2477 IENV----TSHNEKIKSELLIINDALRRVKEKKDEMNKLFNSLTENNNNNNNSAKNIVDNSTYiINELESHVSKLNElls 2552

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  726 ----ELTDLRAEKTSLEKNL---SERKKKSAQERCQAEAEMDEIRKSHQEE 769
Cdd:PTZ00440 2553 yidnEIKELENEKLKLLEKAkieESRKERERIESETQEDNTDEEQINRQQQ 2603
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 569-781 3.51e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 45.04  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   569 IQENERLKQEllekssrieeQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQA------RILHAEQEKAKVTEE 642
Cdd:TIGR00606  417 LQSKERLKQE----------QADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQlegssdRILELDQELRKAERE 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   643 LAAA--TAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQ--------- 711
Cdd:TIGR00606  487 LSKAekNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRhsdeltsll 566

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   712 ----SRRQLELKVTSL-------EEELTDLRAEKTSLEKNL----SERKKKSAQERCQAEAEMDEIRKSHQE-ELDRLRQ 775
Cdd:TIGR00606  567 gyfpNKKQLEDWLHSKskeinqtRDRLAKLNKELASLEQNKnhinNELESKEEQLSSYEDKLFDVCGSQDEEsDLERLKE 646


                   ....*.
gi 568926925   776 LLKKAR 781
Cdd:TIGR00606  647 EIEKSS 652
PRK00106 PRK00106
ribonuclease Y;
618-798 3.72e-04

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 44.86  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  618 LQTATENTQARILHAEQEKAKVTEElaaATAQVSHLqlkmtahqKKETELQlqlTDNLKETDLLRGHvtrlqadlSELRE 697
Cdd:PRK00106   26 MKSAKEAAELTLLNAEQEAVNLRGK---AERDAEHI--------KKTAKRE---SKALKKELLLEAK--------EEARK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  698 ASEQTQTKFKSEKQSRRQLELKVT----SLEEELTDLRAEKTSL---EKNLSErKKKSAQERcqaEAEMDEIRKSHQEEL 770
Cdd:PRK00106   84 YREEIEQEFKSERQELKQIESRLTeratSLDRKDENLSSKEKTLeskEQSLTD-KSKHIDER---EEQVEKLEEQKKAEL 159

                         170       180
                  ....*....|....*....|....*...
gi 568926925  771 DRLRQLlkkarvstDQAAAEQLTLAQAE 798
Cdd:PRK00106  160 ERVAAL--------SQAEAREIILAETE 179
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 565-869 4.18e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 4.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   565 IQRIIQENER---LKQELLEKSSRIEEQNDKISDLIE---------------RNQRYVEQSNLMMEKRNNSLQTATENTQ 626
Cdd:TIGR04523   67 EEKINNSNNKikiLEQQIKDLNDKLKKNKDKINKLNSdlskinseikndkeqKNKLEVELNKLEKQKKENKKNIDKFLTE 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   627 ARILHAE--------------------------QEKAKVTEELAAATAQVSHLQLKMTAHQKKE---TELQLQLTDNLKE 677
Cdd:TIGR04523  147 IKKKEKEleklnnkyndlkkqkeelenelnlleKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIqknKSLESQISELKKQ 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   678 TDLLRGHVTRLQADLSELREASEQTQTKFKSEKQS---------RRQLEL-----KVTSLEE-------ELTDLRAEKTS 736
Cdd:TIGR04523  227 NNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEqnkikkqlsEKQKELeqnnkKIKELEKqlnqlksEISDLNNQKEQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   737 -LEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLK--KARVSTDQAAAEQLTLAQAELQS------QWEAKC 807
Cdd:TIGR04523  307 dWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKelTNSESENSEKQRELEEKQNEIEKlkkenqSYKQEI 386

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925   808 EQLLASARD--EHLQQYREVCAQRDahqQKLALLQDECLALQAQI----AAFTEQKEHMQRLEKTKSQ 869
Cdd:TIGR04523  387 KNLESQINDleSKIQNQEKLNQQKD---EQIKKLQQEKELLEKEIerlkETIIKNNSEIKDLTNQDSV 451
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 694-869 4.34e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.56  E-value: 4.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   694 ELREASEQTQTKFKSEKQSRRQLELKVTSLEEEltdLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKsHQEELDRL 773
Cdd:pfam15709  356 EQEEQRRLQQEQLERAEKMREELELEQQRRFEE---IRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQ-QQEEFRRK 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   774 RQLLKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYRevcaQRDAHQQKlALLQDECLALQAQIAAF 853
Cdd:pfam15709  432 LQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQR----QKQEAEEK-ARLEAEERRQKEEEAAR 506

                          170
                   ....*....|....*.
gi 568926925   854 TEQKEHMQRLEKTKSQ 869
Cdd:pfam15709  507 LALEEAMKQAQEQARQ 522
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 511-779 4.85e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 4.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   511 RQHNTEIRMAVNKVADKMDHLMTKVEELQKHSS--GNSML-LPSMSVTMETSMIMSNIQRIIQENERLKQELLEKSSRI- 586
Cdd:pfam10174  474 KKENKDLKEKVSALQPELTEKESSLIDLKEHASslASSGLkKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTn 553

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   587 EEQNDKISDLIERNQRYVEQSN--------LM-----MEKRNNSLQTATENTQARILHAEQEKAKvteelaaATAQVSHL 653
Cdd:pfam10174  554 PEINDRIRLLEQEVARYKEESGkaqaeverLLgilreVENEKNDKDKKIAELESLTLRQMKEQNK-------KVANIKHG 626

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   654 QLKMtahQKKETELqlqLTDNLKETDLLRGHVTRLQadLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAE 733
Cdd:pfam10174  627 QQEM---KKKGAQL---LEEARRREDNLADNSQQLQ--LEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAE 698

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926925   734 KtslEKNLSERKKKSAQERCQAEAEMD------EI----RKSHQEEL-------DRLRQLLKK 779
Cdd:pfam10174  699 R---RKQLEEILEMKQEALLAAISEKDaniallELssskKKKTQEEVmalkrekDRLVHQLKQ 758
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 632-779 5.77e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 42.59  E-value: 5.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   632 AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQlqltdNLKEtdllrgHVTRLQADLSELREASEQTQTKFKSEKQ 711
Cdd:pfam13851   52 IQQENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLK-----NLKA------RLKVLEKELKDLKWEHEVLEQRFEKVER 120

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925   712 SRRQLELKvtsLEEELTDLRaEKTSLEKNLSERKKKSAQERC-QAEAEMDEIRKSHQEELDRLRQLLKK 779
Cdd:pfam13851  121 ERDELYDK---FEAAIQDVQ-QKTGLKNLLLEKKLQALGETLeKKEAQLNEVLAAANLDPDALQAVTEK 185
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
713-862 6.07e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  713 RRQLELKVTSLEEELTDLRAEKTSLEKnlserkkksAQERCQAEAEMDEIRKSHQE---ELDRLRQLLKKARVSTDQAAA 789
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALED---------AREQIELLEPIRELAERYAAareRLAELEYLRAALRLWFAQRRL 290

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926925  790 EQLTLAQAELQSQWEAKCEQL--LASARDEHLQQYREVCAQRDAHQ-QKLAllqdeclALQAQIAAFTEQKEHMQR 862
Cdd:COG4913   291 ELLEAELEELRAELARLEAELerLEARLDALREELDELEAQIRGNGgDRLE-------QLEREIERLERELEERER 359
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 689-877 6.89e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.64  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  689 QADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEmdEIRKSHQE 768
Cdd:PRK09510   74 AKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAA--AAKAKAEA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  769 ELDRLRQLLKKARVSTD-QAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLAllqdecLALQ 847
Cdd:PRK09510  152 EAKRAAAAAKKAAAEAKkKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAA------EAKA 225

                         170       180       190
                  ....*....|....*....|....*....|
gi 568926925  848 AQIAAFTEQKEHMQRLEKTKSQAPAGRAAA 877
Cdd:PRK09510  226 AAAKAAAEAKAAAEKAAAAKAAEKAAAAKA 255
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 561-822 7.31e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.67  E-value: 7.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQENERLKQELL--------EKSSRIEEQNDKISDLIERN---QRYVEQSN-------LMMEKRNNSLQTAT 622
Cdd:PRK04778  254 IEKEIQDLKEQIDENLALLEeldldeaeEKNEEIQERIDQLYDILEREvkaRKYVEKNSdtlpdflEHAKEQNKELKEEI 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  623 ENTQA--RILHAEQEKAK-VTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKE-TDLLRGHVtRLQADLSELRea 698
Cdd:PRK04778  334 DRVKQsyTLNESELESVRqLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQlEEIEKEQE-KLSEMLQGLR-- 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  699 seqtqtkfKSEKQSRRQLELKVTSLEEelTDLRAEK---TSLEKNLSERKKKSAQERCQAEAEMDEIRKshqeELDRLRQ 775
Cdd:PRK04778  411 --------KDELEAREKLERYRNKLHE--IKRYLEKsnlPGLPEDYLEMFFEVSDEIEALAEELEEKPI----NMEAVNR 476

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 568926925  776 LLKKArvstdQAAAEQLtlaqaelqsqwEAKCEQLLASAR-DEHLQQY 822
Cdd:PRK04778  477 LLEEA-----TEDVETL-----------EEETEELVENATlTEQLIQY 508
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 185-285 7.75e-04

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 42.09  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  185 LVAAEGPAVETGDSLEVAYTGWLLQnhvlGQVFDSTANKDKPLRLKLGSgkVVKGLEDGLLGMKKGGKRLIITPSACAAG 264
Cdd:PRK11570  109 LTQGEGAIPARTDRVRVHYTGKLID----GTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYG 182

                          90       100
                  ....*....|....*....|.
gi 568926925  265 SEGViGWTQPTDSILVFEVEV 285
Cdd:PRK11570  183 ERGA-GASIPPFSTLVFEVEL 202
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 566-803 7.96e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.89  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  566 QRIIQENERLKQELLEKssrIEEQNDKISDL------IERNQRYVEQSNLMMEKRN-------------NSL-QTATENT 625
Cdd:PRK10929   71 QQVIDNFPKLSAELRQQ---LNNERDEPRSVppnmstDALEQEILQVSSQLLEKSRqaqqeqdrareisDSLsQLPQQQT 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  626 QARILHAEQE---KAKVTEELAAATAQVSHLQLKMTAHQKKETELQL-QLTDNLKE------TDLLRGHVTRLQADLSEL 695
Cdd:PRK10929  148 EARRQLNEIErrlQTLGTPNTPLAQAQLTALQAESAALKALVDELELaQLSANNRQelarlrSELAKKRSQQLDAYLQAL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  696 ReaseqTQTKFKSEKQSRRQLElKVTSLEEELTDLRAEKTS-LEKN--LSERKKKSAQercqaeaEMDEIrKSHQEeldr 772
Cdd:PRK10929  228 R-----NQLNSQRQREAERALE-STELLAEQSGDLPKSIVAqFKINreLSQALNQQAQ-------RMDLI-ASQQR---- 289

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568926925  773 lrqllkkarvstdQAAAEQLTLAQA----ELQSQW 803
Cdd:PRK10929  290 -------------QAASQTLQVRQAlntlREQSQW 311
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 561-999 8.04e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.85  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  561 IMSNIQRIIQEnerlKQELLEKSSRIEEQ--NDKISDLierNQRYVEQSNLMMEKRNNSLQTAT-ENTQARILHAEQEKA 637
Cdd:NF033838   63 VESHLEKILSE----IQKSLDKRKHTQNValNKKLSDI---KTEYLYELNVLKEKSEAELTSKTkKELDAAFEQFKKDTL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  638 KVTEELAAATAQVSHLQLKmtAHQKKETELQLQLTDNLK--ETDLLRGHVTRLQADLSELREASEQTQtkfksEKQSRRQ 715
Cdd:NF033838  136 EPGKKVAEATKKVEEAEKK--AKDQKEEDRRNYPTNTYKtlELEIAESDVEVKKAELELVKEEAKEPR-----DEEKIKQ 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  716 LELKVTSLEEELTDLRAEKTSLEKnlSERKKKSAQERCQAEAEMDEIRKSHQE------------ELDRLRQLLKKARvS 783
Cdd:NF033838  209 AKAKVESKKAEATRLEKIKTDREK--AEEEAKRRADAKLKEAVEKNVATSEQDkpkrrakrgvlgEPATPDKKENDAK-S 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  784 TDQAAAEQlTLAQAELqsqweaKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAqiaAFTEQKEHMQRL 863
Cdd:NF033838  286 SDSSVGEE-TLPSPSL------KPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYPTNTYKTLELEI---AESDVKVKEAEL 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  864 EKTKSQAPAGRAaadpSEKVKKIMNQVfQSLRGEfeleesydgGTILRTIMHTIKmvtlqllnhqEEEEEEEEEEEEEKK 943
Cdd:NF033838  356 ELVKEEAKEPRN----EEKIKQAKAKV-ESKKAE---------ATRLEKIKTDRK----------KAEEEAKRKAAEEDK 411

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926925  944 PLRPSLEQPGPATPGMP--PAP--------PSGE---TQEAPEVLPEQVVGETTPLPLQALPTPENGAQ 999
Cdd:NF033838  412 VKEKPAEQPQPAPAPQPekPAPkpekpaeqPKAEkpaDQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQ 480
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
563-775 9.04e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 9.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  563 SNIQRIiqenERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNL--------MMEKRNNSLQTATENTQARILH--- 631
Cdd:COG4913   607 DNRAKL----AALEAELAELEEELAEAEERLEALEAELDALQERREAlqrlaeysWDEIDVASAEREIAELEAELERlda 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  632 -------AEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETD-LLRGHVTRLQADLSELREASEQTq 703
Cdd:COG4913   683 ssddlaaLEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaAEDLARLELRALLEERFAAALGD- 761

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926925  704 tkfKSEKQSRRQLELKVTSLEEELTDLRAEktsLEKNLSERKKKSAQERCQAEAEMDEIRkSHQEELDRLRQ 775
Cdd:COG4913   762 ---AVERELRENLEERIDALRARLNRAEEE---LERAMRAFNREWPAETADLDADLESLP-EYLALLDRLEE 826
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 531-826 1.08e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   531 LMTKVEELQK----HSSGNSmllpsmSVTMETSMIMSNIQRIIQENERLKQELLEKSSRIEEQndkiSDLIERNQRYVeq 606
Cdd:pfam05557  281 LSRRIEQLQQreivLKEENS------SLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRH----KALVRRLQRRV-- 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   607 snLMMEKRNNSLQTATENtqariLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQkkeTELQLQLTDNLKETDLLRGHVT 686
Cdd:pfam05557  349 --LLLTKERDGYRAILES-----YDKELTMSNYSPQLLERIEEAEDMTQKMQAHN---EEMEAQLSVAEEELGGYKQQAQ 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   687 RLQADLSELREASEQTQTKFKSEKQSrrQLELKVTSLEEELTDLRAEKTSLEKNLSER---------KKKSAQERCQAEA 757
Cdd:pfam05557  419 TLERELQALRQQESLADPSYSKEEVD--SLRRKLETLELERQRLREQKNELEMELERRclqgdydpkKTKVLHLSMNPAA 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   758 EMDEIRKSH----QEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEHL--------QQYREV 825
Cdd:pfam05557  497 EAYQQRKNQleklQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKELESAELKNQRLkevfqakiQEFRDV 576


                   .
gi 568926925   826 C 826
Cdd:pfam05557  577 C 577
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 571-869 1.09e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 43.27  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   571 ENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQ-SNLmmEKRNNSLQTATENTQARILHAEQ---EKAKVTEELAaa 646
Cdd:pfam10174  381 EIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQlAGL--KERVKSLQTDSSNTDTALTTLEEalsEKERIIERLK-- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   647 taqvshlqlkmTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSE----LREASEQTQTKFKS--EKQSR-RQLELK 719
Cdd:pfam10174  457 -----------EQREREDRERLEELESLKKENKDLKEKVSALQPELTEkessLIDLKEHASSLASSglKKDSKlKSLEIA 525

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   720 VTSLEEELTDLRAE-KTSLEKNLSERKKKSAQERCQA-EAEM----DEIRKShQEELDRLRQLLKKA---RVSTDQ--AA 788
Cdd:pfam10174  526 VEQKKEECSKLENQlKKAHNAEEAVRTNPEINDRIRLlEQEVarykEESGKA-QAEVERLLGILREVeneKNDKDKkiAE 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   789 AEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDEclalqaqiaafteqkEHMQRLEKTKS 868
Cdd:pfam10174  605 LESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLE---------------ELMGALEKTRQ 669


                   .
gi 568926925   869 Q 869
Cdd:pfam10174  670 E 670
PRK11637 PRK11637
AmiB activator; Provisional
 575-806 1.10e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 43.14  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  575 LKQELLEKSSRIEEQNDKISDLIER----NQRYVEQSNLMMEKRNNSLQTATENTQ--ARILHAEQEKAKVTEELAAata 648
Cdd:PRK11637   52 IQQDIAAKEKSVRQQQQQRASLLAQlkkqEEAISQASRKLRETQNTLNQLNKQIDElnASIAKLEQQQAAQERLLAA--- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  649 qvshlQLKMTAHQKKETELQLqltdnlketdLLRGHVT----RLQADLSELREASEQTQTKFKsekQSRRQLELKVTSLE 724
Cdd:PRK11637  129 -----QLDAAFRQGEHTGLQL----------ILSGEESqrgeRILAYFGYLNQARQETIAELK---QTREELAAQKAELE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  725 EE-------LTDLRAEKTSLEKNLSERKK------KSAQERCQAEAEMdeirksHQEElDRLRQLLKKARVSTDQAAAEQ 791
Cdd:PRK11637  191 EKqsqqktlLYEQQAQQQKLEQARNERKKtltgleSSLQKDQQQLSEL------RANE-SRLRDSIARAEREAKARAERE 263

                         250
                  ....*....|....*
gi 568926925  792 LTLAQAELQSQWEAK 806
Cdd:PRK11637  264 AREAARVRDKQKQAK 278
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
639-889 1.16e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.59  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLEL 718
Cdd:COG1340     6 LSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  719 KVTSLEEELTDLRAEKTSLEKNLSERKKKsaqercqaEAEMDEIRKSHQ-------------EELDRLRQLLKKARVSTD 785
Cdd:COG1340    86 KLNELREELDELRKELAELNKAGGSIDKL--------RKEIERLEWRQQtevlspeeekelvEKIKELEKELEKAKKALE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  786 QAAAEQLTLAQA-ELQSQWEAKCEQL--LASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQI----AAFTEQKE 858
Cdd:COG1340   158 KNEKLKELRAELkELRKEAEEIHKKIkeLAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKAdelhEEIIELQK 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 568926925  859 HMQRLEKT-----KSQAPAGRAAADPS--EKVKKIMNQ 889
Cdd:COG1340   238 ELRELRKElkklrKKQRALKREKEKEEleEKAEEIFEK 275
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
562-713 1.16e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  562 MSNIQRIIQENERLKQELLEKSSRIEEQN-------DKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQ 634
Cdd:COG4717   346 IEELQELLREAEELEEELQLEELEQEIAAllaeagvEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAL 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  635 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDL--LRGHVTRLQADLSEL----------REASEQT 702
Cdd:COG4717   426 DEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELaeLLQELEELKAELRELaeewaalklaLELLEEA 505

                         170
                  ....*....|.
gi 568926925  703 QTKFKSEKQSR 713
Cdd:COG4717   506 REEYREERLPP 516
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 569-812 1.17e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.50  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   569 IQENE-RLKQELLEKSSRIEEQNDKISDLIERNQryvEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAAT 647
Cdd:TIGR00606  370 IQSLAtRLELDGFERGPFSERQIKNFHTLVIERQ---EDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKK 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   648 AQVSHLQLKMtahQKKETELQlQLTDNLKETDLLRGHVTRLQADLSELREAS--EQTQTKFKSEKQSRRQLELKVTSLEE 725
Cdd:TIGR00606  447 EILEKKQEEL---KFVIKELQ-QLEGSSDRILELDQELRKAERELSKAEKNSltETLKKEVKSLQNEKADLDRKLRKLDQ 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   726 ELTDLRAEKTSLEKNLSERKKKSaqercQAEAEMDEIRKSHQEEL--------------DRLRQLLKKARVSTDQAAAEQ 791
Cdd:TIGR00606  523 EMEQLNHHTTTRTQMEMLTKDKM-----DKDEQIRKIKSRHSDELtsllgyfpnkkqleDWLHSKSKEINQTRDRLAKLN 597

                          250       260
                   ....*....|....*....|....*.
gi 568926925   792 LTLAQAE-----LQSQWEAKCEQLLA 812
Cdd:TIGR00606  598 KELASLEqnknhINNELESKEEQLSS 623
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 557-900 1.26e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 42.97  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   557 ETSMIMSNIQRIIQENERLKQELleKSSRIEE--------------QNDKI----SDLIERNQRYVEQSN---------- 608
Cdd:pfam15964  136 ELSEMKQRVQVVVLENEKLQQEL--KSQTQEEtlreqtlldssgnmQNSWCtpedSRVHQTSKRPASHNLaerlksattg 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   609 ------LMMEKRNNSLQTATENTQARILHAEQ---EKAKVTEEL------------AAATAQVSHLQLKMTAHQ----KK 663
Cdd:pfam15964  214 edekwrLELEKLKLLYEAKTEVLESQVKSLRKdlaESQKTCEDLkerlkhkeslvaASTSSRVGGLCLKCAQHEavlaQT 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   664 ETELQLQLTDNL-KETDLLRGHVTRLQADLSEL--REASEQTQTKFKSEKQSRRQLElKVTSL---EEELTDLRAEKTSL 737
Cdd:pfam15964  294 HTNVHMQTIERLtKERDDLMSALVSVRSSLAEAqqRESSAYEQVKQAVQMTEEANFE-KTKALiqcEQLKSELERQKERL 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   738 EKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQ------AAAEQLTLAQAELQSQwEAKCEQLL 811
Cdd:pfam15964  373 EKELASQQEKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEKvtreknSLVSQLEEAQKQLASQ-EMDVTKVC 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   812 ASAR----------DEHLQQYREVCA-------------------------QRDAHQQKLALLQDECLALqAQIAAFTEQ 856
Cdd:pfam15964  452 GEMRyqlnqtkmkkDEAEKEHREYRTktgrqleikdqeieklglelseskqRLEQAQQDAARAREECLKL-TELLGESEH 530

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 568926925   857 KEHMQRLEKTKSQAPAGRAAAdpsekvkkimNQVFQSLRGEFEL 900
Cdd:pfam15964  531 QLHLTRLEKESIQQSFSNEAK----------AQALQAQQREQEL 564
NtpE COG1390
Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal ...
 741-912 1.30e-03

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 441000 [Multi-domain]  Cd Length: 196  Bit Score: 41.47  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  741 LSERKKKSAQERCQAEAEMDEIRKSHQEELDRLR-QLLKKARVSTDQAAAEQltLAQAELQSQweakceQLLASARDEHL 819
Cdd:COG1390    12 LEEAEAEAEEILEEAEEEAEKILEEAEEEAEEIKeEILEKAEREAEREKRRI--ISSAELEAR------KELLEAKEELI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  820 QQYREvcaqrdahqqklallqdeclALQAQIAAFTEQKEHMQRLEKT----KSQAPAGRAAADPSEKVKKIMNQVFQSLR 895
Cdd:COG1390    84 EEVFE--------------------EALEKLKNLPKDPEYKELLKKLlkeaAEELGSGDLVVYVNEKDKELLEELLKELK 143

                         170       180
                  ....*....|....*....|.
gi 568926925  896 GE-FELEE---SYDGGTILRT 912
Cdd:COG1390   144 KKgLEVSEediDILGGVIVES 164
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 631-882 1.33e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.51  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  631 HAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEK 710
Cdd:COG3883    13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  711 QSRRQLELKVTSLE-----EELTDLrAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKkarvstd 785
Cdd:COG3883    93 RALYRSGGSVSYLDvllgsESFSDF-LDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKA------- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  786 qaaaeQLTLAQAELQSQWEAKcEQLLASARdehlqqyrevcAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEK 865
Cdd:COG3883   165 -----ELEAAKAELEAQQAEQ-EALLAQLS-----------AEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227

                         250
                  ....*....|....*..
gi 568926925  866 TKSQAPAGRAAADPSEK 882
Cdd:COG3883   228 AAAAAAAAAAAAAAAAA 244
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 648-869 1.35e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   648 AQVSHLQLKMTAHQK-KETELQLQLTDNLKETDL-LRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLE---LKVTS 722
Cdd:TIGR00606  187 ALETLRQVRQTQGQKvQEHQMELKYLKQYKEKACeIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEhnlSKIMK 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   723 LEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQ 802
Cdd:TIGR00606  267 LDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELL 346

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   803 WEAKCEQLLASARDEHLQQYrEVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQ 869
Cdd:TIGR00606  347 VEQGRLQLQADRHQEHIRAR-DSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQ 412
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 569-951 1.36e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  569 IQENERLKQELlekssRIEEQNDKISDlIERNQRYVEQsnlmmeKRNNSLQTATENTQARILHAEQEKAKVTEELAAATA 648
Cdd:COG5185   127 KSEIVALKDEL-----IKVEKLDEIAD-IEASYGEVET------GIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISE 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  649 QVSHLQLKMTAHQKKETELQLQLTDNLKETdllrghvtrlqADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELT 728
Cdd:COG5185   195 LKKAEPSGTVNSIKESETGNLGSESTLLEK-----------AKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNT 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  729 DLRAEKTSLEKNLSERKKKsaqercQAEAEMDEIRKsHQEELDRlrqllkkarvSTDQAAAEQLTLaqaELQSQWEAkce 808
Cdd:COG5185   264 DLRLEKLGENAESSKRLNE------NANNLIKQFEN-TKEKIAE----------YTKSIDIKKATE---SLEEQLAA--- 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  809 qllASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQApagRAAADPSEKVKKIMN 888
Cdd:COG5185   321 ---AEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEEL---DSFKDTIESTKESLD 394

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926925  889 QVFQSLRGEFELeesydggtILRTIMHTIKMVTLQLLNHQEEEEEEEEEEEEEKKPLRPSLEQ 951
Cdd:COG5185   395 EIPQNQRGYAQE--------ILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISE 449
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 662-777 1.39e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 39.93  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   662 KKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSE--KQSR-----RQLELKVTSLEEELTDLRAEK 734
Cdd:pfam07926    1 AELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERElvLHAEdikalQALREELNELKAEIAELKAEA 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 568926925   735 TSLEKNLSERKKKSAQERCQAEAEMDEIRKSHqEELDRLRQLL 777
Cdd:pfam07926   81 ESAKAELEESEESWEEQKKELEKELSELEKRI-EDLNEQNKLL 122
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 704-906 1.41e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   704 TKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKksaqercQAEAEMDEIRKSHQEELDRLRQLLKKARVS 783
Cdd:pfam12128  244 TKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSA-------ELNQLLRTLDDQWKEKRDELNGELSAADAA 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   784 TdqaaaeqltlaqaelqsqweAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRL 863
Cdd:pfam12128  317 V--------------------AKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAK 376

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 568926925   864 EKTKSQAPAGRAAADPSEKVKKIMNQVFQSLRGEFELEESYDG 906
Cdd:pfam12128  377 YNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQA 419
COG5022 COG5022
Myosin heavy chain [General function prediction only];
662-897 1.46e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.14  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  662 KKETELQLQLTDNLKETDLLRGHVtrLQADLSElreaSEQTQTKFKSEKQS--RRQLELKVTSLEEELTDLRAEKTSLE- 738
Cdd:COG5022   823 QKTIKREKKLRETEEVEFSLKAEV--LIQKFGR----SLKAKKRFSLLKKEtiYLQSAQRVELAERQLQELKIDVKSISs 896

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  739 -KNLSERKKKSAQE-RCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQSQ---WEAKCEQL--L 811
Cdd:COG5022   897 lKLVNLELESEIIElKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNKLHEVeskLKETSEEYedL 976

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  812 ASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQiaafTEQKEHMQR-------LEKTKSQAPAGRAAADPSEKVK 884
Cdd:COG5022   977 LKKSTILVREGNKANSELKNFKKELAELSKQYGALQES----TKQLKELPVevaelqsASKIISSESTELSILKPLQKLK 1052

                         250
                  ....*....|...
gi 568926925  885 KIMNQVFQSLRGE 897
Cdd:COG5022  1053 GLLLLENNQLQAR 1065
PRK12704 PRK12704
phosphodiesterase; Provisional
 626-802 1.71e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  626 QARILHAEQEKAKVTEElAAATAQVshlqlkmtahQKKETELQLQltdnlKETDLLRghvTRLQADLSELREASEQTQTK 705
Cdd:PRK12704   30 EAKIKEAEEEAKRILEE-AKKEAEA----------IKKEALLEAK-----EEIHKLR---NEFEKELRERRNELQKLEKR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  706 FKSEKQS-RRQLELkVTSLEEELTDLRAEKTSLEKNLSERKKksaqercqaeaEMDEIRKSHQEELDRLRQLlkkarvST 784
Cdd:PRK12704   91 LLQKEENlDRKLEL-LEKREEELEKKEKELEQKQQELEKKEE-----------ELEELIEEQLQELERISGL------TA 152

                         170
                  ....*....|....*...
gi 568926925  785 DQAAAEQLTLAQAELQSQ 802
Cdd:PRK12704  153 EEAKEILLEKVEEEARHE 170
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
751-870 1.75e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  751 ERCQAEAEMDEIrKSHQEELDRLRQLLKKARvstdqaaaeqltlAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRD 830
Cdd:COG4913   219 EEPDTFEAADAL-VEHFDDLERAHEALEDAR-------------EQIELLEPIRELAERYAAARERLAELEYLRAALRLW 284

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568926925  831 AHQQKLALLQDECLALQAQIAAFTEQKEhmqRLEKTKSQA 870
Cdd:COG4913   285 FAQRRLELLEAELEELRAELARLEAELE---RLEARLDAL 321
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
571-781 1.75e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  571 ENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILhaeqEKAKVT--EELAAATA 648
Cdd:COG4717   317 EEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL----AEAGVEdeEELRAALE 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  649 QVSHLQlkmtAHQKKETELQLQLTDNLKETDLLRGhvtrlQADLSELREASEQTQTKfksekqsRRQLELKVTSLEEELT 728
Cdd:COG4717   393 QAEEYQ----ELKEELEELEEQLEELLGELEELLE-----ALDEEELEEELEELEEE-------LEELEEELEELREELA 456

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925  729 DLRAEKTSLEKNLSERKKKSAQERCQAEAE---------------MDEIRKSHQEEldRLRQLLKKAR 781
Cdd:COG4717   457 ELEAELEQLEEDGELAELLQELEELKAELRelaeewaalklalelLEEAREEYREE--RLPPVLERAS 522
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 559-798 1.82e-03

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 41.63  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   559 SMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSL---QTATENTQARILHAEQ- 634
Cdd:pfam06008    8 TGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLakaQQVNAESERTLGHAKEl 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   635 -EKAK-VTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREAS---EQTQTKFKSE 709
Cdd:pfam06008   88 aEAIKnLIDNIKEINEKVATLGENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQdllSRIQTWFQSP 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   710 KQSRRQLElkvTSLEEELTDLRAEKTSLEKNLSE--RKKKSAQERCQAEAEMDEIRKSHQEELDRLR----QLLKKARVS 783
Cdd:pfam06008  168 QEENKALA---NALRDSLAEYEAKLSDLRELLREaaAKTRDANRLNLANQANLREFQRKKEEVSEQKnqleETLKTARDS 244

                          250
                   ....*....|....*
gi 568926925   784 TDQAAaeqLTLAQAE 798
Cdd:pfam06008  245 LDAAN---LLLQEID 256
Tropomyosin_1 pfam12718
Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and ...
 692-810 2.03e-03

Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and Tpm2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpm1p spans five. Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis. The family also contains higher eukaryote Tpm3 members.


Pssm-ID: 403808 [Multi-domain]  Cd Length: 142  Bit Score: 39.98  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   692 LSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDL-------RAEKTSLEKNLSERKKK---SAQERCQAEA---- 757
Cdd:pfam12718    2 MNSLKLEAENAQERAEELEEKVKELEQENLEKEQEIKSLthknqqlEEEVEKLEEQLKEAKEKaeeSEKLKTNNENltrk 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926925   758 ------EMDEIRKSHQEELDRLRQllkkarvsTDqAAAEQLTLAQAELQS---QWEAKCEQL 810
Cdd:pfam12718   82 iqlleeELEESDKRLKETTEKLRE--------TD-VKAEHLERKVQALEQerdEWEKKYEEL 134
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
571-824 2.03e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  571 ENERLKQELLEKSSRIEEQNDKISDLIER-NQRYVEQSNLmmEKRNNSLQTATENTQARI------LHAEQEKAKVTEEL 643
Cdd:PRK02224  371 ELEEAREAVEDRREEIEELEEEIEELRERfGDAPVDLGNA--EDFLEELREERDELREREaeleatLRTARERVEEAEAL 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  644 AAA---------TAQVSHLQLKMTAHQKKEtELQLQLTDNLKETDLLRGHVTRLqadlSELREASEQTQTKFKSEKQSRR 714
Cdd:PRK02224  449 LEAgkcpecgqpVEGSPHVETIEEDRERVE-ELEAELEDLEEEVEEVEERLERA----EDLVEAEDRIERLEERREDLEE 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  715 QLELKVTSLEEE---LTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEI------RKSHQEELDRLRqllkkaRVSTD 785
Cdd:PRK02224  524 LIAERRETIEEKrerAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVaelnskLAELKERIESLE------RIRTL 597

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 568926925  786 QAAAEQLTLAQAELQSQWEAKCEqlLASARDEHLQQYRE 824
Cdd:PRK02224  598 LAAIADAEDEIERLREKREALAE--LNDERRERLAEKRE 634
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 638-880 2.19e-03

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 41.24  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   638 KVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQtkfksekQSRRQLE 717
Cdd:pfam06008   16 KINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTL-------GHAKELA 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   718 LKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERcQAEAE--MDEIRKshqeeldrlRQLLKKARVSTDQAAAEQLTLA 795
Cdd:pfam06008   89 EAIKNLIDNIKEINEKVATLGENDFALPSSDLSRM-LAEAQrmLGEIRS---------RDFGTQLQNAEAELKAAQDLLS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   796 QA-ELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQAPAGR 874
Cdd:pfam06008  159 RIqTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETL 238


                   ....*.
gi 568926925   875 AAADPS 880
Cdd:pfam06008  239 KTARDS 244
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
654-865 2.19e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  654 QLKMTAHQKKETELQLQLTDnlketdllrghvtrLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEEltdlRAE 733
Cdd:PRK02224  191 QLKAQIEEKEEKDLHERLNG--------------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER----REE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  734 KTSLEKNLSE-RKKKSAQERcQAEAEMDEIRkSHQEELDRLRQLLKKARVST--DQAAAEQLTLAQAELQSQwEAKCEQL 810
Cdd:PRK02224  253 LETLEAEIEDlRETIAETER-EREELAEEVR-DLRERLEELEEERDDLLAEAglDDADAEAVEARREELEDR-DEELRDR 329

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926925  811 LASAR---DEHLQQYREVCAQRDAHQQKLALLQDECLALQAQI----AAFTEQKEHMQRLEK 865
Cdd:PRK02224  330 LEECRvaaQAHNEEAESLREDADDLEERAEELREEAAELESELeearEAVEDRREEIEELEE 391
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 302-497 2.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   302 SSRDSAAPSPIPASDSLSADPVVTPLPLPLKPGEPGLRsksnslseqlTVNSNPDTVKAKLISRMAKMgQPMLPILPPQl 381
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT----------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPS- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   382 dSNDSETEDATVLRGAGQSLVTP-SIQPSLQPaHPVLPQMASQAPQPSGSglQTPSAAlmqavsldshsavsgnaqnfQP 460
Cdd:pfam03154  260 -QVSPQPLPQPSLHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVPPGP--------------------SP 315

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 568926925   461 YAGVQAYAYPQTPSVTSQLQP-----VRPLYPAPLSQaPHFQ 497
Cdd:pfam03154  316 AAPGQSQQRIHTPPSQSQLQSqqpprEQPLPPAPLSM-PHIK 356
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 601-869 2.56e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 42.09  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  601 QRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAataqvshLQLKMTAHQkketelqlqltdnlketdl 680
Cdd:PRK10246  238 AQQQQQQSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAA-------LSLAQPARQ------------------- 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  681 LRGHVTRLQ---ADLSELREASEQTQTKFKSEKQSRRQLElkvTSLEEELTDLRAEKTSLEKNLSE--RKKKSAQERCQA 755
Cdd:PRK10246  292 LRPHWERIQeqsAALAHTRQQIEEVNTRLQSTMALRARIR---HHAAKQSAELQAQQQSLNTWLAEhdRFRQWNNELAGW 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  756 EAEMDEiRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAElqsqweakceqlLASARDEHLQQ--YRE----VCAQR 829
Cdd:PRK10246  369 RAQFSQ-QTSDREQLRQWQQQLTHAEQKLNALPAITLTLTADE------------VAAALAQHAEQrpLRQrlvaLHGQI 435

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 568926925  830 DAHQQKLALLQDECLALQAQIAAFTEQKEHMQRLEKTKSQ 869
Cdd:PRK10246  436 VPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQ 475
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 606-878 2.59e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   606 QSNLMMEKRNNSLQTATENTQARilHAEQEkakvtEELAAATAQVSHLQLKMT--AHQKKETELQLQLTDNLKETDLLRG 683
Cdd:pfam12128  597 ASEEELRERLDKAEEALQSAREK--QAAAE-----EQLVQANGELEKASREETfaRTALKNARLDLRRLFDEKQSEKDKK 669

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   684 HvtrlQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNL-SERKKKSAQ-------ERCQA 755
Cdd:pfam12128  670 N----KALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVeGALDAQLALlkaaiaaRRSGA 745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   756 EAEMDEIRKSHQEELDRLR-QLLKKARVSTDQAAAEQlTLAQAelqsqweAKCEQLLASARDEHLQQYREvcaQRDAHQQ 834
Cdd:pfam12128  746 KAELKALETWYKRDLASLGvDPDVIAKLKREIRTLER-KIERI-------AVRRQEVLRYFDWYQETWLQ---RRPRLAT 814

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 568926925   835 KLALLQDECLALQAQIAAFTEQKEhmQRLEKTKSQAPAGRAAAD 878
Cdd:pfam12128  815 QLSNIERAISELQQQLARLIADTK--LRRAKLEMERKASEKQQV 856
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
 681-779 2.61e-03

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 39.61  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   681 LRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQercqaeaemd 760
Cdd:pfam11559   64 LEAEIERLQSKIERLKTQLEDLERELALLQAKERQLEKKLKTLEQKLKNEKEELQRLKNALQQIKTQFAH---------- 133

                           90
                   ....*....|....*....
gi 568926925   761 EIRKsHQEELDRLRQLLKK 779
Cdd:pfam11559  134 EVKK-RDREIEKLKERLAQ 151
DUF4618 pfam15397
Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...
 684-866 2.74e-03

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.


Pssm-ID: 464704 [Multi-domain]  Cd Length: 258  Bit Score: 41.09  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   684 HVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRaekTSLEKnlsERKKKSAQeRCQAEAEMDEIR 763
Cdd:pfam15397   61 NKKQLQQAKAELQEWEEKEESKLNKLEQQLEQLNAKIQKTQEELNFLS---TYKDK---EYPVKAVQ-IANLVRQLQQLK 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   764 KSHQEELDRLRQLLKKARvstdqaaaeqltlaqAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLAllqdEC 843
Cdd:pfam15397  134 DSQQDELDELEEMRRMVL---------------ESLSRKIQKKKEKILSSLAEKTLSPYQESLLQKTRDNQVML----KE 194

                          170       180
                   ....*....|....*....|...
gi 568926925   844 LALQAQIAAftEQKEHMQRLEKT 866
Cdd:pfam15397  195 IEQFREFID--ELEEEIPKLKAE 215
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 562-856 2.74e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.34  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   562 MSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEkrnnSLQTATE--------NTQARILHAE 633
Cdd:TIGR00606  321 LVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQ----SLATRLEldgfergpFSERQIKNFH 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   634 QEKAKVTEELAAATAQ-VSHLQLKMTAHQKKETELQLQLTDNLKetdLLRGHVTRLQADLSELREASEQTQtkfKSEKQS 712
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQlCADLQSKERLKQEQADEIRDEKKGLGR---TIELKKEILEKKQEELKFVIKELQ---QLEGSS 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   713 RRQLElkvtsLEEELTDLRAEKTSLEKN-LSERKKKSAQERCQAEAEMDEIRKSHQEELDRLR---------QLLKKARV 782
Cdd:TIGR00606  471 DRILE-----LDQELRKAERELSKAEKNsLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNhhtttrtqmEMLTKDKM 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   783 STDQAAAEQLTLAQAELQSQ-----WEAKCEQLLASARDEhLQQYREVCAQRDAHQQKLALLQ----DECLALQAQIAAF 853
Cdd:TIGR00606  546 DKDEQIRKIKSRHSDELTSLlgyfpNKKQLEDWLHSKSKE-INQTRDRLAKLNKELASLEQNKnhinNELESKEEQLSSY 624


                   ...
gi 568926925   854 TEQ 856
Cdd:TIGR00606  625 EDK 627
PRK15095 PRK15095
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 214-266 3.24e-03

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 237908 [Multi-domain]  Cd Length: 156  Bit Score: 39.69  E-value: 3.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568926925  214 GQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACAAGSE 266
Cdd:PRK15095   22 GSTAESTRNNGKPALFRLGDGSLSEGLEQQLLGLKVGDKKTFSLEPEAAFGVP 74
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 533-779 3.55e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 3.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   533 TKVEELQKH-SSGNSMLLpsmSVTMETSMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDL--------------- 596
Cdd:TIGR04523  482 QNLEQKQKElKSKEKELK---KLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLedelnkddfelkken 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   597 ----IERNQRYVEQsnlmMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLT 672
Cdd:TIGR04523  559 lekeIDEKNKEIEE----LKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIK 634

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   673 DnlketdllrghvtrLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDL-RAEKTSL-EKNLSERKKKSAQ 750
Cdd:TIGR04523  635 N--------------IKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIiELMKDWLkELSLHYKKYITRM 700

                          250       260
                   ....*....|....*....|....*....
gi 568926925   751 ERCQAEAEMDEIRKSHQEELDRLRQLLKK 779
Cdd:TIGR04523  701 IRIKDLPKLEEKYKEIEKELKKLDEFSKE 729
CENP-F_leu_zip pfam10473
Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 668-800 4.27e-03

Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance.


Pssm-ID: 463102 [Multi-domain]  Cd Length: 140  Bit Score: 38.82  E-value: 4.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   668 QLQLTDNLKET----DLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTslekNLSE 743
Cdd:pfam10473    5 QLHVLEKLKESerkaDSLKDKVENLERELEMSEENQELAILEAENSKAEVETLKAEIEEMAQNLRDLELDLV----TLRS 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   744 RKKKSAQERCQAEAEMDEIRKSHqEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQ 800
Cdd:pfam10473   81 EKENLTKELQKKQERVSELESLN-SSLENLLEEKEQEKVQMKEESKTAVEMLQTQLK 136
PRK01156 PRK01156
chromosome segregation protein; Provisional
 562-864 4.30e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.43  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  562 MSNIQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSlqtatENTQARILHAEQEKAKVTE 641
Cdd:PRK01156  182 ISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNL-----KSALNELSSLEDMKNRYES 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  642 ELAAATAQVSHLQLKMTAHQKKETELQlQLTDN--LKETDLLRGHVTrLQADLSELREASEQTQTKFKSEKQSRRQLEL- 718
Cdd:PRK01156  257 EIKTAESDLSMELEKNNYYKELEERHM-KIINDpvYKNRNYINDYFK-YKNDIENKKQILSNIDAEINKYHAIIKKLSVl 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  719 ------------KVTSLEEELTDLRAEKT---SLEKNLSERKKKSAQERCQAE---AEMDEIRKSHQEELDRLRQLLKKA 780
Cdd:PRK01156  335 qkdyndyikkksRYDDLNNQILELEGYEMdynSYLKSIESLKKKIEEYSKNIErmsAFISEILKIQEIDPDAIKKELNEI 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  781 RVSTDQAAAEqltlaQAELQSQWEAKCEQLLASARDEHLQQYREVCAQ-------------RDAHQQKLALLQDECLALQ 847
Cdd:PRK01156  415 NVKLQDISSK-----VSSLNQRIRALRENLDELSRNMEMLNGQSVCPVcgttlgeeksnhiINHYNEKKSRLEEKIREIE 489

                         330
                  ....*....|....*..
gi 568926925  848 AQIAAFTEQKEHMQRLE 864
Cdd:PRK01156  490 IEVKDIDEKIVDLKKRK 506
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 570-842 4.35e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 41.74  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  570 QENERLKQELLEKSSRIEEQNDKISDLIERN----QRYVEQSNLMMEKRNNSLQTATENT--QARI------LHAEQEKA 637
Cdd:PTZ00440  560 KLKRSMKNDIKNKIKYIEENVDHIKDIISLNdeidNIIQQIEELINEALFNKEKFINEKNdlQEKVkyilnkFYKGDLQE 639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  638 KVTEEL------------AAATAQVSHLQLKMTAHQKKETELQL----QLTDNLKetdllrghvTRLQaDLSELREA--S 699
Cdd:PTZ00440  640 LLDELShflddhkylyheAKSKEDLQTLLNTSKNEYEKLEFMKSdnidNIIKNLK---------KELQ-NLLSLKENiiK 709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  700 EQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLE---KNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQL 776
Cdd:PTZ00440  710 KQLNNIEQDISNSLNQYTIKYNDLKSSIEEYKEEEEKLEvykHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTI 789

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  777 LKKARVSTDQAAA--EQLTLAQAELQSqWEAKCEQLLASAR--DEHLQQYREVCAQRDahqQKLALLQDE 842
Cdd:PTZ00440  790 LNKENKISNDINIlkENKKNNQDLLNS-YNILIQKLEAHTEknDEELKQLLQKFPTED---ENLNLKELE 855
HAP1_N pfam04849
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ...
 574-824 4.38e-03

HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.


Pssm-ID: 461455 [Multi-domain]  Cd Length: 309  Bit Score: 40.78  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   574 RLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQ---TATENTQARILHAEQEKAKVTEELAAATAQV 650
Cdd:pfam04849   87 RIGQSLLKQNSVLTERNEALEEQLGSAREEILQLRHELSKKDDLLQiysNDAEESETESSCSTPLRRNESFSSLHGCVQL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   651 SHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADL-SELREASeqTQTKFKSEkqsrrQLELKVtsleEELTD 729
Cdd:pfam04849  167 DALQEKLRGLEEENLKLRSEASHLKTETDTYEEKEQQLMSDCvEQLSEAN--QQMAELSE-----ELARKM----EENLR 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   730 LRAEKTSLEKNLSErkkksAQERCqaeaemdeirKSHQEELDRLRQLLKKARvstdqAAAEQLTLAQAELQSQWeAKCEQ 809
Cdd:pfam04849  236 QQEEITSLLAQIVD-----LQHKC----------KELGIENEELQQHLQASK-----EAQRQLTSELQELQDRY-AECLG 294

                          250
                   ....*....|....*
gi 568926925   810 LLASARDEhLQQYRE 824
Cdd:pfam04849  295 MLHEAQEE-LKELRK 308
FAM184 pfam15665
Family with sequence similarity 184, A and B; The function of FAM184 is not known.
 512-708 4.51e-03

Family with sequence similarity 184, A and B; The function of FAM184 is not known.


Pssm-ID: 464788 [Multi-domain]  Cd Length: 211  Bit Score: 40.03  E-value: 4.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   512 QHNTEIRMAVNKVADKMDHLMTKVEE---LQKHSSgnsmllpsmsvTMETSmimsniqriIQENERLKQELLEK----SS 584
Cdd:pfam15665   22 AHEEEIQQILAETREKILQYKSKIGEeldLKRRIQ-----------TLEES---------LEQHERMKRQALTEfeqyKR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   585 RIEEQNDKISDliERNQRYVEQSNLMMEKRNN---SLQTATENTQArilhAEQEKAKVTEELAAATAQ-VSHLQLKMTAH 660
Cdd:pfam15665   82 RVEERELKAEA--EHRQRVVELSREVEEAKRAfeeKLESFEQLQAQ----FEQEKRKALEELRAKHRQeIQELLTTQRAQ 155

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 568926925   661 QKKETELQLQLTDNLK-ETDLLRGHVTRLQADLSELREASEQTQTKFKS 708
Cdd:pfam15665  156 SASSLAEQEKLEELHKaELESLRKEVEDLRKEKKKLAEEYEQKLSKAQA 204
growth_prot_Scy NF041483
polarized growth protein Scy;
566-884 4.70e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  566 QRIIQEN----ERLKQELLEKSSRIEEQNDKisDLIERNQ---RYVEQSNLMMEKrnnsLQTATEnTQARILhAEQEKAK 638
Cdd:NF041483  104 QRILQEHaehqARLQAELHTEAVQRRQQLDQ--ELAERRQtveSHVNENVAWAEQ----LRARTE-SQARRL-LDESRAE 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  639 VTEELAAATAQVShlQLKMTAHQKKETELQLQLTDnlKETDLLRGHVTR---LQADLSELREAS---EQTQTKFKSE-KQ 711
Cdd:NF041483  176 AEQALAAARAEAE--RLAEEARQRLGSEAESARAE--AEAILRRARKDAerlLNAASTQAQEATdhaEQLRSSTAAEsDQ 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  712 SRRQL-------ELKVTSLEEELTDLRAEKtslEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVST 784
Cdd:NF041483  252 ARRQAaelsraaEQRMQEAEEALREARAEA---EKVVAEAKEAAAKQLASAESANEQRTRTAKEEIARLVGEATKEAEAL 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  785 dQAAAEQLtLAQAelqsqwEAKCEQLLASARDehlqQYREVCAQRDAHQ-QKLALLQDECLA-----LQAQIAAFTEQKE 858
Cdd:NF041483  329 -KAEAEQA-LADA------RAEAEKLVAEAAE----KARTVAAEDTAAQlAKAARTAEEVLTkasedAKATTRAAAEEAE 396

                         330       340
                  ....*....|....*....|....*....
gi 568926925  859 HMQRlektKSQAPAGR---AAADPSEKVK 884
Cdd:NF041483  397 RIRR----EAEAEADRlrgEAADQAEQLK 421
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
679-781 4.88e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.00  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  679 DLLRGHVTRLQADLSELREASEQTQTKFKSEKQSR-RQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEA 757
Cdd:COG2433   380 EALEELIEKELPEEEPEAEREKEHEERELTEEEEEiRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERR 459

                          90       100
                  ....*....|....*....|....*.
gi 568926925  758 EMDEIRK--SHQEELDRLRQLLKKAR 781
Cdd:COG2433   460 EIRKDREisRLDREIERLERELEEER 485
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 633-752 6.06e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 40.81  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   633 EQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTD-----NLKETDL---------LRGHVTRLQADLSELREA 698
Cdd:pfam05911  694 KSEKENLEVELASCTENLESTKSQLQESEQLIAELRSELASlkesnSLAETQLkcmaesyedLETRLTELEAELNELRQK 773

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925   699 SEQTQTKFKSEKQSRRQLELKVTSLEEELTdlRAEKTSLEKNL-SERKKKSAQER 752
Cdd:pfam05911  774 FEALEVELEEEKNCHEELEAKCLELQEQLE--RNEKKESSNCDaDQEDKKLQQEK 826
SYCE1 pfam15233
Synaptonemal complex central element protein 1; This family of proteins includes synaptonemal ...
 628-764 6.17e-03

Synaptonemal complex central element protein 1; This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis.


Pssm-ID: 464575 [Multi-domain]  Cd Length: 152  Bit Score: 38.64  E-value: 6.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   628 RILHAEQEKAKVTEELAAATAQVSHLQ------------LKMTAHQKKETELQLQLTDNLKETDLLRGHvtrlqADLSEL 695
Cdd:pfam15233   13 RINELQQAKKKSSEELGEAQALWEALQreldslngekvhLEEVLNKKQEALRILQLHCQEKESEAQRQH-----TLNEEC 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926925   696 REASEQTQTKFKSEKQSRRQLELKVtslEEELTDLraekTSLEKNLSE--RKKKSAQERCQAEAEMDEIRK 764
Cdd:pfam15233   88 KQRIEQYTFQIQEEKLKHRKQRMDF---EEQLEDL----MEQHKDLWEfhVPQRLAREIRALESSKEQLLK 151
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 620-877 6.23e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 40.94  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  620 TATENTQARILHAEQEK-----AKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQA---- 690
Cdd:PRK10246  407 TADEVAAALAQHAEQRPlrqrlVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTiceq 486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  691 -----DLSELRE-----------------ASEQTQTKFKSEKQSRR-QLELKVTSLEEELTDLRAEKTSLEKNLsERKKK 747
Cdd:PRK10246  487 earikDLEAQRAqlqagqpcplcgstshpAVEAYQALEPGVNQSRLdALEKEVKKLGEEGAALRGQLDALTKQL-QRDES 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  748 SAQERCQAEAEM------------------DEI------RKSHQEELDRLRQllKKARVSTDQAAAEQLTLAQAELQSQW 803
Cdd:PRK10246  566 EAQSLRQEEQALtqqwqavcaslnitlqpqDDIqpwldaQEEHERQLRLLSQ--RHELQGQIAAHNQQIIQYQQQIEQRQ 643

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  804 EAKCEQLLA---------------SARDEHLQQYREVCAQRDAHQQKLALLQ---------------------------- 840
Cdd:PRK10246  644 QQLLTALAGyaltlpqedeeaswlATRQQEAQSWQQRQNELTALQNRIQQLTplletlpqsddlphseetvaldnwrqvh 723

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 568926925  841 DECLALQAQIAAFTEQK-EHMQRLEKTKSQAPAGRAAA 877
Cdd:PRK10246  724 EQCLSLHSQLQTLQQQDvLEAQRLQKAQAQFDTALQAS 761
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
565-784 7.13e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.79  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  565 IQRIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQsnlMMEKRN--NSLQTATENTQARILHAEQEKAKVTEE 642
Cdd:PRK02224  511 IERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAE---AEEKREaaAEAEEEAEEAREEVAELNSKLAELKER 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  643 L-------------AAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRG-----HVTRLQADLSELREASEQTQT 704
Cdd:PRK02224  588 IeslerirtllaaiADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAefdeaRIEEAREDKERAEEYLEQVEE 667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  705 KFKSEKQSRRQLELKVTSLEEELTDLraektsleKNLSERkKKSAQERCQA-EAEMDEIrkshqEELD----RLRQLLKK 779
Cdd:PRK02224  668 KLDELREERDDLQAEIGAVENELEEL--------EELRER-REALENRVEAlEALYDEA-----EELEsmygDLRAELRQ 733


                  ....*
gi 568926925  780 ARVST 784
Cdd:PRK02224  734 RNVET 738
mukB PRK04863
chromosome partition protein MukB;
507-783 7.16e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.71  E-value: 7.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  507 MTEARQHNTEIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSMImsniqriiqenERLkQELLEKSSRI 586
Cdd:PRK04863  839 LRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADETLA-----------DRV-EEIREQLDEA 906

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  587 EEqnDKISdlIERNQRYVEQsnlmMEKRNNSLQTATEN---TQARILHAEQEKAKVTEELAAATAQVSHLqlkmtAHQKK 663
Cdd:PRK04863  907 EE--AKRF--VQQHGNALAQ----LEPIVSVLQSDPEQfeqLKQDYQQAQQTQRDAKQQAFALTEVVQRR-----AHFSY 973

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  664 ETELQLqLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKF----------KSEKQSRRQLelkVTSLEEELTDL--- 730
Cdd:PRK04863  974 EDAAEM-LAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLaqynqvlaslKSSYDAKRQM---LQELKQELQDLgvp 1049

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926925  731 ---------RAEKTSLEKNLSE-RKKKSAQERCQA--EAEMDEIRK---SHQEELDRLRQLLKKARVS 783
Cdd:PRK04863 1050 adsgaeeraRARRDELHARLSAnRSRRNQLEKQLTfcEAEMDNLTKklrKLERDYHEMREQVVNAKAG 1117
PHA03247 PHA03247
large tegument protein UL36; Provisional
 302-495 7.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  302 SSRDSAAPSPIPASDSLSADPVVTPLPLPLKPGEPGlrskSNSLSEQLTVNSNPDTVKAKLISRMAKMGQPMLPILPPQ- 380
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP----PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  381 ----------------LDSNDSETEDATVLRGAGQSLVTPSIQPSLQPAHPVLPqmASQAPQPSGSGLQTPSAALMQAvs 444
Cdd:PHA03247 2683 prrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPARPA-- 2758

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926925  445 ldSHSAVSGNAQNFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPH 495
Cdd:PHA03247 2759 --RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP 2807
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
508-785 7.39e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.89  E-value: 7.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  508 TEARQHNT---EIRMAVNKVADKMDHLMTKV----EELQKHSSgnsmllpsmsvtmETSMIMSNIQRIIQENERLKQELL 580
Cdd:COG1340    22 EEIEELKEkrdELNEELKELAEKRDELNAQVkelrEEAQELRE-------------KRDELNEKVKELKEERDELNEKLN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  581 EKSSRIEEQN-------------DKISDLIERNQRYVEQSNLMMEKRNNSLQTATEntQARILHAEQEKAKVTEELAAAT 647
Cdd:COG1340    89 ELREELDELRkelaelnkaggsiDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKE--LEKELEKAKKALEKNEKLKELR 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  648 AQVSHLQLKM-TAHQKKET------ELQLQLTDNLKETDllrghvtrlqadlsELREASEQTQTKFKSEKQSRRQLELKV 720
Cdd:COG1340   167 AELKELRKEAeEIHKKIKElaeeaqELHEEMIELYKEAD--------------ELRKEADELHKEIVEAQEKADELHEEI 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  721 TSLEEELTDLRAEKTSLEKNLSERKKKSAQErcqaeaemdEIRKSHQEELDRLRqllKKARVSTD 785
Cdd:COG1340   233 IELQKELRELRKELKKLRKKQRALKREKEKE---------ELEEKAEEIFEKLK---KGEKLTTE 285
growth_prot_Scy NF041483
polarized growth protein Scy;
672-831 7.48e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 40.58  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  672 TDNLKETDLLRGHVTRLQADL-SELREASEQTQTKFKSEKQSRR-----QLELKVTSLEEELTDLRAEK----TSLEKNL 741
Cdd:NF041483  909 SDAAAQADRLIGEATSEAERLtAEARAEAERLRDEARAEAERVRadaaaQAEQLIAEATGEAERLRAEAaetvGSAQQHA 988

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  742 SERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTlaqaELQSQWEAKCEQLLASARDEHLQQ 821
Cdd:NF041483  989 ERIRTEAERVKAEAAAEAERLRTEAREEADRTLDEARKDANKRRSEAAEQAD----TLITEAAAEADQLTAKAQEEALRT 1064

                         170
                  ....*....|
gi 568926925  822 YREVCAQRDA 831
Cdd:NF041483 1065 TTEAEAQADT 1074
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 632-840 7.80e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 39.28  E-value: 7.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   632 AEQEKAKVTEELAAATAQV--SHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQaDLSELREASEQTQTKFKSe 709
Cdd:pfam04012   34 MQSELVKARQALAQTIARQkqLERRLEQQTEQAKKLEEKAQAALTKGNEELAREALAEKK-SLEKQAEALETQLAQQRS- 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   710 kqSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKkksaqercqaeaemdeirksHQEELDrlrQLLKKARVSTDQAAA 789
Cdd:pfam04012  112 --AVEQLRKQLAALETKIQQLKAKKNLLKARLKAAK--------------------AQEAVQ---TSLGSLSTSSATDSF 166

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568926925   790 EQLTLAQAELQSQWEAKCEqlLASARDEhLQQYREVCAQRDAHQQKLALLQ 840
Cdd:pfam04012  167 ERIEEKIEEREARADAAAE--LASAVDL-DAKLEQAGIQMEVSEDVLARLK 214
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 718-852 8.29e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 40.45  E-value: 8.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  718 LKVTSLEEELTDLRAEKTSLEKnlserkkksaqERCQAEAEMDEirkSHQEELDRLRQLLKKARvstdqaaaEQLtlaqA 797
Cdd:COG0542   404 MEIDSKPEELDELERRLEQLEI-----------EKEALKKEQDE---ASFERLAELRDELAELE--------EEL----E 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568926925  798 ELQSQWEakceqllasARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAA 852
Cdd:COG0542   458 ALKARWE---------AEKELIEEIQELKEELEQRYGKIPELEKELAELEEELAE 503
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 696-809 8.42e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.48  E-value: 8.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   696 REASEQT----QTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKnlsERKKKSAQERCQAEAEMDEIRKSHQEELD 771
Cdd:pfam05672   21 RQAREQRereeQERLEKEEEERLRKEELRRRAEEERARREEEARRLEE---ERRREEEERQRKAEEEAEEREQREQEEQE 97

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 568926925   772 RLRQLLKKARVSTdQAAAEQLTLAQAELQSQWEAKCEQ 809
Cdd:pfam05672   98 RLQKQKEEAEAKA-REEAERQRQEREKIMQQEEQERLE 134
PHA03247 PHA03247
large tegument protein UL36; Provisional
 309-501 9.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 9.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  309 PSPIPASDSLSADPVVTPLPL--PLKPGEPglrsksnsLSEQLTVNSNPDTVKAKLISRMAKMGQPMLPilpPQLDSnds 386
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPPSLPLggSVAPGGD--------VRRRPPSRSPAAKPAAPARPPVRRLARPAVS---RSTES--- 2897

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  387 etedatvlrgagQSLVTPSIQPSLQPAHPVLPQMASQAPQPSGSGLQTPSAALMQA-VSLDSHSAVSGNAQNFQPYAGVQ 465
Cdd:PHA03247 2898 ------------FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPpLAPTTDPAGAGEPSGAVPQPWLG 2965

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 568926925  466 AYAYPQTPSVTSQLQPVRPLYPAPLSQAPHFQGSGD 501
Cdd:PHA03247 2966 ALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
Filament pfam00038
Intermediate filament protein;
570-777 9.43e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 39.52  E-value: 9.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   570 QENERLkQEL-------LEKSSRIEEQND----KISDLIERNQRYVEQSNLMMEK-----RNNSLQTATENTQARI---- 629
Cdd:pfam00038    1 NEKEQL-QELndrlasyIDKVRFLEQQNKlletKISELRQKKGAEPSRLYSLYEKeiedlRRQLDTLTVERARLQLeldn 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   630 --LHAEQEKAKVTEELA-----------------AATAQVSHLQLKMTA-----------HQKKETELQLQLTDN--LKE 677
Cdd:pfam00038   80 lrLAAEDFRQKYEDELNlrtsaendlvglrkdldEATLARVDLEAKIESlkeelaflkknHEEEVRELQAQVSDTqvNVE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   678 TDLLRGhvTRLQADLSELR------------EASEQTQTKF-----------------KSE-KQSRRQLElkvtSLEEEL 727
Cdd:pfam00038  160 MDAARK--LDLTSALAEIRaqyeeiaaknreEAEEWYQSKLeelqqaaarngdalrsaKEEiTELRRTIQ----SLEIEL 233

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568926925   728 TDLRAEKTSLEKNLSERKKKSAQERCQA-------EAEMDEIRKSHQEELDRLRQLL 777
Cdd:pfam00038  234 QSLKKQKASLERQLAETEERYELQLADYqeliselEAELQETRQEMARQLREYQELL 290
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
664-779 9.48e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.23  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925  664 ETELQLQLTDNLKETDLLRGHVTRLQADLSELR-------EASEQTQTKFKSEKQSRRQLELKvtslEEELTDLRAEKTS 736
Cdd:COG2433   401 KEHEERELTEEEEEIRRLEEQVERLEAEVEELEaeleekdERIERLERELSEARSEERREIRK----DREISRLDREIER 476

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568926925  737 LEKNLserkkksaqercqaeAEMDEIRKSHQEELDRLRQLLKK 779
Cdd:COG2433   477 LEREL---------------EEERERIEELKRKLERLKELWKL 504
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 570-951 9.51e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 9.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   570 QENERLKQEL-LEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQtatentQARILHAEQEKAKVTEELAAATA 648
Cdd:TIGR00618  386 QQKTTLTQKLqSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQ------QRYAELCAAAITCTAQCEKLEKI 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   649 QVSHLQLKMTAHQKKETELQlQLTDNLKETDLLRGHVTRLQADL------SELREASEQTQTKFKSEKQSR-RQLELKVT 721
Cdd:TIGR00618  460 HLQESAQSLKEREQQLQTKE-QIHLQETRKKAVVLARLLELQEEpcplcgSCIHPNPARQDIDNPGPLTRRmQRGEQTYA 538

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   722 SLEEELTDLRAEKTSLEKNLSERKKKsAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQaELQS 801
Cdd:TIGR00618  539 QLETSEEDVYHQLTSERKQRASLKEQ-MQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLAC-EQHA 616

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   802 QWEAKCEQLlasaRDEHLQQYREVCAQRDahQQKLALLQDECLALQAQiaaftEQKEHMQRLEKTKSQAPAGRAAADPSE 881
Cdd:TIGR00618  617 LLRKLQPEQ----DLQDVRLHLQQCSQEL--ALKLTALHALQLTLTQE-----RVREHALSIRVLPKELLASRQLALQKM 685

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   882 KVKKimnqvfQSLRGEFELeesydggtilrtimhtikmvtlqlLNHQEEEEEEEEEEEEEKKPLRPSLEQ 951
Cdd:TIGR00618  686 QSEK------EQLTYWKEM------------------------LAQCQTLLRELETHIEEYDREFNEIEN 725
Apolipoprotein pfam01442
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ...
 638-824 9.76e-03

Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.


Pssm-ID: 460211 [Multi-domain]  Cd Length: 175  Bit Score: 38.40  E-value: 9.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   638 KVTEELAAATAQVSHLQLKMtAHQKKETELQLqltdnLKETDLLRGhvtRLQADLSELREASEQTQTKFKSEKQSR-RQL 716
Cdd:pfam01442    1 LLEDSLDELSTYAEELQEQL-GPVAQELVDRL-----EKETEALRE---RLQKDLEEVRAKLEPYLEELQAKLGQNvEEL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926925   717 ELKVTSLEEELTDLRAEKT-SLEKNLSErkkKSAQERCQAEAEMDEIRKSHQEELDRLRQLLkKARVstdQAAAEQLTLA 795
Cdd:pfam01442   72 RQRLEPYTEELRKRLNADAeELQEKLAP---YGEELRERLEQNVDALRARLAPYAEELRQKL-AERL---EELKESLAPY 144

                          170       180
                   ....*....|....*....|....*....
gi 568926925   796 QAELQSQWEAKCEQLLASArDEHLQQYRE 824
Cdd:pfam01442  145 AEEVQAQLSQRLQELREKL-EPQAEDLRE 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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