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Conserved domains on  [gi|569005633|ref|XP_006531736|]
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latent-transforming growth factor beta-binding protein 3 isoform X9 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 223-264 1.14e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.67  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005633   223 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 264
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 738-780 8.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 8.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005633   738 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 780
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-199 3.39e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.39e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    164 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 199
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
553-593 5.93e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 5.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    553 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 593
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
891-926 8.45e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.45e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    891 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 926
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-503 1.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005633  469 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 503
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
594-634 2.61e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.61e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    594 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 634
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 955-991 3.93e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005633   955 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 991
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
675-708 6.26e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.26e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005633    675 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 708
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
635-674 1.32e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005633    635 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 674
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
845-873 7.99e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.99e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005633    845 DVDECLDESNCRNG-VCENTRGGYRCACTP 873
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-545 2.55e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005633    512 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 545
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-468 3.86e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005633    425 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 468
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
TB super family cl02926
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 100-130 7.03e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


The actual alignment was detected with superfamily member pfam00683:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.33  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   100 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 130
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1063-1101 7.33e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005633   1063 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1101
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 223-264 1.14e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.67  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005633   223 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 264
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 738-780 8.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 8.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005633   738 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 780
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-199 3.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.39e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    164 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 199
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
553-593 5.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 5.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    553 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 593
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
891-926 8.45e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.45e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    891 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 926
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-503 1.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005633  469 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 503
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
594-634 2.61e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.61e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    594 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 634
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-501 2.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.69e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005633    469 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 501
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 955-991 3.93e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005633   955 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 991
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 164-196 4.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005633  164 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 196
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 553-584 6.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.11e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569005633  553 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 584
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
675-708 6.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.26e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005633    675 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 708
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 675-710 8.61e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 8.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  675 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 710
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 594-628 1.05e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  594 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 628
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 891-931 1.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569005633  891 DVDECQDPAACRP-GRCVNLPGSYRCECHPPWEpgpsGRDCQ 931
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
635-674 1.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005633    635 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 674
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 635-674 3.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569005633  635 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 674
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
845-873 7.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.99e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005633    845 DVDECLDESNCRNG-VCENTRGGYRCACTP 873
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
635-664 1.12e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   635 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 664
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
164-193 1.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   164 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 193
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-545 2.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005633    512 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 545
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 845-873 2.59e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.59e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 569005633  845 DVDECLDESNCRN-GVCENTRGGYRCACTP 873
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-468 3.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005633    425 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 468
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
594-623 4.05e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   594 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 623
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 512-544 5.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005633  512 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 544
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-459 6.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  425 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 459
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 100-130 7.03e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.33  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   100 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 130
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1063-1101 7.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005633   1063 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1101
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 223-264 1.14e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.67  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005633   223 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 264
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 738-780 8.53e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 8.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005633   738 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 780
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-199 3.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 3.39e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    164 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 199
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
553-593 5.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 5.93e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    553 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 593
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
891-926 8.45e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.45e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005633    891 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 926
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-503 1.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005633  469 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 503
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
594-634 2.61e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.61e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005633    594 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 634
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-501 2.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.69e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005633    469 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 501
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 955-991 3.93e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.88  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005633   955 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 991
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 164-196 4.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005633  164 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 196
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 553-584 6.11e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.11e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569005633  553 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 584
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
675-708 6.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.26e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005633    675 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 708
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 675-710 8.61e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 8.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  675 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 710
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 594-628 1.05e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  594 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 628
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 891-931 1.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569005633  891 DVDECQDPAACRP-GRCVNLPGSYRCECHPPWEpgpsGRDCQ 931
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
635-674 1.32e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005633    635 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 674
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 635-674 3.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569005633  635 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 674
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
845-873 7.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.99e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005633    845 DVDECLDESNCRNG-VCENTRGGYRCACTP 873
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 670-713 9.74e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 9.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569005633  670 GRKCQDIDECSqdpglCLPHG---ACENLQGSYVCVCDEGFTLTQDQ 713
Cdd:cd01475   181 GKICVVPDLCA-----TLSHVcqqVCISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
635-664 1.12e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   635 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 664
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
164-193 1.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   164 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 193
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-545 2.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005633    512 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 545
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 592-629 2.57e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569005633  592 CIDVDECEAG-KVCQDgICTNTPGSFQCQCLSGYHLSRD 629
Cdd:cd01475   184 CVVPDLCATLsHVCQQ-VCISTPGSYLCACTEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 845-873 2.59e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.59e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 569005633  845 DVDECLDESNCRN-GVCENTRGGYRCACTP 873
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-468 3.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005633    425 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 468
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
594-623 4.05e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   594 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 623
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 512-544 5.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005633  512 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 544
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-459 6.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005633  425 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 459
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
167-199 6.33e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 6.33e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005633    167 ECAMPGMCRHGDCLNNPGSYRCVCPPGHSLGPS 199
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 100-130 7.03e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 35.33  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005633   100 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 130
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1063-1101 7.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005633   1063 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1101
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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