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Conserved domains on  [gi|578838380|ref|XP_006724718|]
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serine/threonine-protein kinase PAK 3 isoform X1 [Homo sapiens]

Protein Classification

serine/threonine-protein kinase PAK( domain architecture ID 11108706)

serine/threonine-protein kinase PAK (p21-activated kinase) catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and is a Rho family GTPase-regulated kinase that mediates the function of Cdc42 (cell division cycle 42) and Rac

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
275-530 0e+00

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 568.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06647    1 SVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd06647   81 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd06647  161 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 240
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd06647  241 LEMDVEKRGSAKELLQ 256
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
69-141 5.85e-22

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


:

Pssm-ID: 395634  Cd Length: 59  Bit Score: 89.29  E-value: 5.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380   69 EISLPSDFEHTIHVGFDAVTGEFTpdlygsqmcpgklpeGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY 141
Cdd:pfam00786   1 MISAPTNFKHTVHVGFDPDTGFFT---------------GLPPEWAKLLDSSGITEDEQKENPKAVLDVLKFY 58
 
Name Accession Description Interval E-value
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
275-530 0e+00

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 568.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06647    1 SVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd06647   81 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd06647  161 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 240
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd06647  241 LEMDVEKRGSAKELLQ 256
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
283-530 4.08e-99

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 300.99  E-value: 4.08e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDrERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   362 GGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQsKRSTMVGT 440
Cdd:smart00220  81 GGDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGE-KLTTFVGT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE-RLSAVFRDFLNRCLEMDV 519
Cdd:smart00220 160 PEYMAPEVLLGKGYGKAVDIWSLGVILYELLTGKPPFPGDDQLLELFKKIGKPKPPFPPPEwDISPEAKDLIRKLLVKDP 239
                          250
                   ....*....|.
gi 578838380   520 DRRGSAKELLQ 530
Cdd:smart00220 240 EKRLTAEEALQ 250
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
282-539 6.79e-66

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 222.20  E-value: 6.79e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:COG0515    8 RYRILRLLGRGGMGVVYLARDLRLGRPVALKVLRpeLAADPEaRERFRREARALARLNHPNIVRVYDVGEEDGRPYLVME 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-T 436
Cdd:COG0515   88 YVEGESLADLLRRRgPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTgT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQNPERLSAVFRDFLNRCL 515
Cdd:COG0515  168 VVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLTGRPPFDGDSPAELLRAHLREpPPPPSELRPDLPPALDAIVLRAL 247
                        250       260
                 ....*....|....*....|....*
gi 578838380 516 EMDVDRR-GSAKELLQVLLAGGNSL 539
Cdd:COG0515  248 AKDPEERyQSAAELAAALRAVLRSL 272
Pkinase pfam00069
Protein kinase domain;
283-530 4.43e-64

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 208.64  E-value: 4.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKKKDknILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  361 AGGSLTDVVTE-TCMDEGQIAAVCREclqaldflhsnqvihrdiksdnILLGMDGSVKLTDFgfcaqitpeqskrstmVG 439
Cdd:pfam00069  81 EGGSLFDLLSEkGAFSEREAKFIMKQ----------------------ILEGLESGSSLTTF----------------VG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:pfam00069 123 TPWYMAPEVLGGNPYGPKVDVWSLGCILYELLTGKPPFPGINGNEIYELIIDQPYAFPELPSNLSEEAKDLLKKLLKKDP 202
                         250
                  ....*....|.
gi 578838380  520 DRRGSAKELLQ 530
Cdd:pfam00069 203 SKRLTATQALQ 213
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
287-526 2.10e-36

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 138.41  E-value: 2.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:PTZ00263  24 ETLGTGSFGRVRIAKHKGTGEYYAIKCLKKREilkMKQVQHVAQEKSILMELSHPFIVNMMCSFQDENRVYFLLEFVVGG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTETCMDEGQIAAV-CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeqSKRSTMVGTPY 442
Cdd:PTZ00263 104 ELFTHLRKAGRFPNDVAKFyHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKKVP---DRTFTLCGTPE 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:PTZ00263 181 YLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGYPPFFDDTPFRIYEKILAG---RLKFPNWFDGRARDLVKGLLQTDHTKR 257

                 ....*
gi 578838380 523 -GSAK 526
Cdd:PTZ00263 258 lGTLK 262
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
287-482 1.19e-28

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 119.90  E-value: 1.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILVMR---ENKN------PNIVNYLDsylVGDE---LW 354
Cdd:NF033483  13 ERIGRGGMAEVYLAKDTRLDRDVAVKVL------RPDLARDPEFVARfrrEAQSaaslshPNIVSVYD---VGEDggiPY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTEtcmdEG-----QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG---FCAQ 426
Cdd:NF033483  84 IVMEYVDGRTLKDYIRE----HGplspeEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGiarALSS 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 427 ITPEQSkrSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:NF033483 160 TTMTQT--NSVLGTVHYLSPEQARGGTVDARSDIYSLGIVLYEMLTGRPPFDGDSP 213
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
69-141 5.85e-22

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 89.29  E-value: 5.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380   69 EISLPSDFEHTIHVGFDAVTGEFTpdlygsqmcpgklpeGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY 141
Cdd:pfam00786   1 MISAPTNFKHTVHVGFDPDTGFFT---------------GLPPEWAKLLDSSGITEDEQKENPKAVLDVLKFY 58
CRIB_PAK_like cd01093
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
68-128 1.72e-19

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. This subgroup of CRIB/PBD-domains is found N-terminal of Serine/Threonine kinase domains in PAK and PAK-like proteins.


Pssm-ID: 238526  Cd Length: 46  Bit Score: 81.93  E-value: 1.72e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380  68 PEISLPSDFEHTIHVGFDAVTGEFTpdlygsqmcpgklpeGIPEQWARLLQTSNITKLEQK 128
Cdd:cd01093    1 PEISSPTNFKHRVHVGFDPQTGEFT---------------GLPEEWQRLLKSSGITKEEQK 46
 
Name Accession Description Interval E-value
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
275-530 0e+00

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 568.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06647    1 SVGDPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd06647   81 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd06647  161 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 240
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd06647  241 LEMDVEKRGSAKELLQ 256
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
263-530 0e+00

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 555.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 263 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 342
Cdd:cd06656    1 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 343 YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Cdd:cd06656   81 YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 423 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 502
Cdd:cd06656  161 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 240
                        250       260
                 ....*....|....*....|....*...
gi 578838380 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06656  241 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 268
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
262-530 0e+00

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 549.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 262 TDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341
Cdd:cd06654    1 SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd06654   81 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501
Cdd:cd06654  161 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE 240
                        250       260
                 ....*....|....*....|....*....
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06654  241 KLSAIFRDFLNRCLEMDVEKRGSAKELLQ 269
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
263-530 0e+00

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 517.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 263 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 342
Cdd:cd06655    1 DEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 343 YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Cdd:cd06655   81 FLDSFLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 423 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 502
Cdd:cd06655  161 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEK 240
                        250       260
                 ....*....|....*....|....*...
gi 578838380 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06655  241 LSPIFRDFLNRCLEMDVEKRGSAKELLQ 268
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
282-530 1.74e-166

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 472.85  E-value: 1.74e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd06614    1 LYKNLEKIGEGASGEVYKATDRATGKEVAIKKMRLRKQ-NKELIINEILIMKECKHPNIVDYYDSYLVGDELWVVMEYMD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:cd06614   80 GGSLTDIITQNpvRMNESQIAYVCREVLQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLTKEKSKRNSVVG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:cd06614  160 TPYWMAPEVIKRKDYGPKVDIWSLGIMCIEMAEGEPPYLEEPPLRALFLITTKGIPPLKNPEKWSPEFKDFLNKCLVKDP 239
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd06614  240 EKRPSAEELLQ 250
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
282-530 5.95e-136

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 395.03  E-value: 5.95e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd05122    1 LFEILEKIGKGGFGVVYKARHKKTGQIVAIKKINLESKEKKESILNEIAILKKCKHPNIVKYYGSYLKKDELWIVMEFCS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSkRSTMVG 439
Cdd:cd05122   81 GGSLKDLLKNTNktLTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSAQLSDGKT-RNTFVG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:cd05122  160 TPYWMAPEVIQGKPYGFKADIWSLGITAIEMAEGKPPYSELPPMKALFLIATNGPPGLRNPKKWSKEFKDFLKKCLQKDP 239
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd05122  240 EKRPTAEQLLK 250
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
275-530 2.16e-130

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 381.02  E-value: 2.16e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06648    1 SPGDPRSDLDNFVKIGEGSTGIVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd06648   81 VVMEFLEGGALTDIVTHTRMNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGFCAQVSKEVPRR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd06648  161 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRIRDNEPPKLKNLHKVSPRLRSFLDRM 240
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd06648  241 LVRDPAQRATAAELLN 256
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
261-530 6.13e-109

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 327.71  E-value: 6.13e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 261 MTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNI 340
Cdd:cd06659    1 VTHEQFKAALRMVVDQGDPRQLLENYVKIGEGSTGVVCIAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHPNV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
Cdd:cd06659   81 VEMYKSYLVGEELWVLMEYLQGGALTDIVSQTRLNEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP 500
Cdd:cd06659  161 FGFCAQISKDVPKRKSLVGTPYWMAPEVISRCPYGTEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 578838380 501 ERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06659  241 HKASPVLRDFLERMLVRDPQERATAQELLD 270
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
282-530 2.47e-99

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 301.53  E-value: 2.47e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd06613    1 DYELIQRIGSGTYGDVYKARNIATGELAAVKVIKLEPGDDFEIIQQEISMLKECRHPNIVAYFGSYLRRDKLWIVMEYCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 440
Cdd:cd06613   81 GGSLQDIYQVTGpLSELQIAYVCRETLKGLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQLTATIAKRKSFIGT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFLNRCL 515
Cdd:cd06613  161 PYWMAPEVaaVERKgGYDGKCDIWALGITAIELAELQPPMFDLHPMRALFLIPKSNfdPPKLKDKEKWSPDFHDFIKKCL 240
                        250
                 ....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQ 530
Cdd:cd06613  241 TKNPKKRPTATKLLQ 255
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
260-530 3.83e-99

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 302.34  E-value: 3.83e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 260 KMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 339
Cdd:cd06658    1 RVSHEQFRAALQLVVSPGDPREYLDSFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHEN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 340 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 419
Cdd:cd06658   81 VVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 420 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN 499
Cdd:cd06658  161 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKD 240
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 500 PERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06658  241 SHKVSSVLRGFLDLMLVREPSQRATAQELLQ 271
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
283-530 4.08e-99

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 300.99  E-value: 4.08e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDrERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   362 GGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQsKRSTMVGT 440
Cdd:smart00220  81 GGDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGE-KLTTFVGT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE-RLSAVFRDFLNRCLEMDV 519
Cdd:smart00220 160 PEYMAPEVLLGKGYGKAVDIWSLGVILYELLTGKPPFPGDDQLLELFKKIGKPKPPFPPPEwDISPEAKDLIRKLLVKDP 239
                          250
                   ....*....|.
gi 578838380   520 DRRGSAKELLQ 530
Cdd:smart00220 240 EKRLTAEEALQ 250
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
281-530 6.20e-98

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 298.39  E-value: 6.20e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd06609    1 ELFTLLERIGKGSFGEVYKGIDKRTNQVVAIKVIDLEEAEDEiEDIQQEIQFLSQCDSPYITKYYGSFLKGSKLWIIMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:cd06609   81 CGGGSVLDLLKPGPLDETYIAFILREVLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLADFGVSGQLTSTMSKRNTFVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFRDFLNRCLEMDV 519
Cdd:cd06609  161 TPFWMAPEVIKQSGYDEKADIWSLGITAIELAKGEPPLSDLHPMRVLFLIPKNNPPSLEGNK-FSKPFKDFVELCLNKDP 239
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd06609  240 KERPSAKELLK 250
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
262-530 7.65e-98

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 299.25  E-value: 7.65e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 262 TDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341
Cdd:cd06657    1 SHEQFRAALQMVVDPGDPRTYLDNFIKIGEGSTGIVCIATVKSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd06657   81 EMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPE 501
Cdd:cd06657  161 GFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLH 240
                        250       260
                 ....*....|....*....|....*....
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06657  241 KVSPSLKGFLDRLLVRDPAQRATAAELLK 269
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
279-530 2.82e-97

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 296.10  E-value: 2.82e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQqqPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd06612    1 PEEVFDILEKLGEGSYGSVYKAIHKETGQVVAIKVVPVE--EDLQEIIKEISILKQCDSPYIVKYYGSYFKNTDLWIVME 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06612   79 YCGAGSVSDIMKITNktLTEEEIAAILYQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKLADFGVSGQLTDTMAKRNT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 516
Cdd:cd06612  159 VIGTPFWMAPEVIQEIGYNNKADIWSLGITAIEMAEGKPPYSDIHPMRAIFMIPNKPPPTLSDPEKWSPEFNDFVKKCLV 238
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06612  239 KDPEERPSAIQLLQ 252
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
282-530 4.09e-89

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 275.17  E-value: 4.09e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd06606    1 RWKKGELLGKGSFGSVYLALNLDTGELMAVKEVELSGDSEEELeaLEREIRILSSLKHPNIVRYLGTERTENTLNIFLEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI----TPEQSKr 434
Cdd:cd06606   81 VPGGSLASLLkKFGKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAKRLaeiaTGEGTK- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 sTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELqnPERLSAVFRDFLN 512
Cdd:cd06606  160 -SLRGTPYWMAPEVIRGEGYGRAADIWSLGCTVIEMATGKPPWSElGNPVAALFKIGSSGEpPPI--PEHLSEEAKDFLR 236
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd06606  237 KCLQRDPKKRPTADELLQ 254
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
281-530 5.60e-86

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 267.69  E-value: 5.60e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd06610    1 DDYELIEVIGSGATAVVYAAYCLPKKEKVAIKRIDLEKcQTSMDELRKEIQAMSQCNHPNVVSYYTSFVVGDELWLVMPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDV----VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-TPEQSK- 433
Cdd:cd06610   81 LSGGSLLDImkssYPRGGLDEAIIATVLKEVLKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVSASLaTGGDRTr 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 --RSTMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN---PERLSAVF 507
Cdd:cd06610  161 kvRKTFVGTPCWMAPEVMEQvRGYDFKADIWSFGITAIELATGAAPYSKYPPMKVLMLTLQNDPPSLETgadYKKYSKSF 240
                        250       260
                 ....*....|....*....|...
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06610  241 RKMISLCLQKDPSKRPTAEELLK 263
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
278-530 2.57e-85

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 266.09  E-value: 2.57e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKElIINEILVMRENKN-PNIVNYLDSYL------VG 350
Cdd:cd06608    3 DPAGIFELVEVIGEGTYGKVYKARHKKTGQLAAIKIMDIIEDEEEE-IKLEINILRKFSNhPNIATFYGAFIkkdppgGD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 425
Cdd:cd06608   82 DQLWLVMEYCGGGSVTDLVKGLrkkgkRLKEEWIAYILRETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFGVSA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSKRSTMVGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP 500
Cdd:cd06608  162 QLDSTLGRRNTFIGTPYWMAPEVIACDqqpdaSYDARCDVWSLGITAIELADGKPPLCDMHPMRALFKIPRNPPPTLKSP 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 578838380 501 ERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06608  242 EKWSKEFNDFISECLIKNYEQRPFTEELLE 271
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
282-530 1.02e-81

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 256.00  E-value: 1.02e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd06627    1 NYQLGDLIGRGAFGSVYKGLNLNTGEFVAIKQISLEKIPKSDLksVMGEIDLLKKLNHPNIVKYIGSVKTKDSLYIILEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd06627   81 VENGSLASIIKKfGKFPESLVAVYIYQVLEGLAYLHEQGVIHRDIKGANILTTKDGLVKLADFGVATKLNEVEKDENSVV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqnPERLSAVFRDFLNRCLEMD 518
Cdd:cd06627  161 GTPYWMAPEVIEMSGVTTASDIWSVGCTVIELLTGNPPYYDLQPMAALFRIVQDDHPPL--PENISPELRDFLLQCFQKD 238
                        250
                 ....*....|..
gi 578838380 519 VDRRGSAKELLQ 530
Cdd:cd06627  239 PTLRPSAKELLK 250
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
289-530 1.39e-80

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 253.90  E-value: 1.39e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd06611   13 LGDGAFGKVYKAQHKETGLFAAAKIIQIESEEELEDFMVEIDILSECKHPNIVGLYEAYFYENKLWILIEFCDGGALDSI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 V--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 446
Cdd:cd06611   93 MleLERGLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGVSAKNKSTLQKRDTFIGTPYWMAP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 447 EVV---TRK--AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd06611  173 EVVaceTFKdnPYDYKADIWSLGITLIELAQMEPPHHELNPMRVLLKILKSEPPTLDQPSKWSSSFNDFLKSCLVKDPDD 252

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd06611  253 RPTAAELLK 261
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
283-530 1.81e-80

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 253.55  E-value: 1.81e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQqPKKEL--IINEILVM---RENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06917    3 YRRLELVGRGSYGAVYRGYHVKTGRVVALKVLNLDT-DDDDVsdIQKEVALLsqlKLGQPKNIIKYYGSYLKGPSLWIIM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd06917   82 DYCEGGSIRTLMRAGPIAERYIAVIMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAASLNQNSSKRSTF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqNPERLSAVFRDFLNRCLE 516
Cdd:cd06917  162 VGTPYWMAPEVITEgKYYDTKADIWSLGITTYEMATGNPPYSDVDALRAVMLIPKSKPPRL-EGNGYSPLLKEFVAACLD 240
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06917  241 EEPKDRLSADELLK 254
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
278-530 8.60e-75

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 238.80  E-value: 8.60e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd06642    1 DPEELFTKLERIGKGSFGEVYKGIDNRTKEVVAIKIIDLEEaEDEIEDIQQEITVLSQCDSPYITRYYGSYLKGTKLWII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06642   81 MEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpeRLSAVFRDFLNRCLE 516
Cdd:cd06642  161 FVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEG--QHSKPFKEFVEACLN 238
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06642  239 KDPRFRPTAKELLK 252
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
289-530 6.72e-73

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 231.78  E-value: 6.72e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd00180    1 LGKGSFGKVYKARDKETGKKVAVKVIPKEKLKKlLEELLREIEILKKLNHPNIVKLYDVFETENFLYLVMEYCEGGSLKD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG--TPYW 443
Cdd:cd00180   81 LLKEnkGPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGttPPYY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMvegeppylnenplralyliatngtpelqnperlsAVFRDFLNRCLEMDVDRRG 523
Cdd:cd00180  161 APPELLGGRYYGPKVDIWSLGVILYEL----------------------------------EELKDLIRRMLQYDPKKRP 206

                 ....*..
gi 578838380 524 SAKELLQ 530
Cdd:cd00180  207 SAKELLE 213
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
278-530 1.59e-72

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 233.02  E-value: 1.59e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd06640    1 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEaEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06640   81 MEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpeRLSAVFRDFLNRCLE 516
Cdd:cd06640  161 FVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG--DFSKPFKEFIDACLN 238
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06640  239 KDPSFRPTAKELLK 252
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
281-530 5.13e-72

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 231.18  E-value: 5.13e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06607    1 KIFEDLREIGHGSFGAVYYARNKRTSEVVAIKKMSYsgkQSTEKWQDIIKEVKFLRQLRHPNTIEYKGCYLREHTAWLVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGgSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSkrs 435
Cdd:cd06607   81 EYCLG-SASDIveVHKKPLQEVEIAAICHGALQGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSASLVCPANS--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 tMVGTPYWMAPEVVTRKAYGP---KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFRDFLN 512
Cdd:cd06607  157 -FVGTPYWMAPEVILAMDEGQydgKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLSSGE-WSDDFRNFVD 234
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd06607  235 SCLQKIPQDRPSAEDLLK 252
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
278-530 1.42e-70

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 228.37  E-value: 1.42e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06643    2 NPEDFWEIVGELGDGAFGKVYKAQNKETGILAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
Cdd:cd06643   82 EFCAGGAVDAVMLEleRPLTEPQIRVVCKQTLEALVYLHENKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTLQRRD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVV-----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDF 510
Cdd:cd06643  162 SFIGTPYWMAPEVVmcetsKDRPYDYKADVWSLGVTLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSPEFKDF 241
                        250       260
                 ....*....|....*....|
gi 578838380 511 LNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06643  242 LRKCLEKNVDARWTTSQLLQ 261
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
278-530 2.33e-70

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 227.26  E-value: 2.33e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd06641    1 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEaEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06641   81 MEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN* 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpeRLSAVFRDFLNRCLE 516
Cdd:cd06641  161 FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 238
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06641  239 KEPSFRPTAKELLK 252
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
282-530 8.35e-68

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 220.03  E-value: 8.35e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE--LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd08215    1 KYEKIRVIGKGSFGSAYLVRRKSDGKLYVLKEIDLSNMSEKEreEALNEVKLLSKLKHPNIVKYYESFEENGKLCIVMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETC-----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd08215   81 ADGGDLAQKIKKQKkkgqpFPEEQILDWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFGISKVLESTTDLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPElQNPERLSAVFRDFLNRC 514
Cdd:cd08215  161 KTVVGTPYYLSPELCENKPYNYKSDIWALGCVLYELCTLKHPFEANN-LPALVYKIVKGQYP-PIPSQYSSELRDLVNSM 238
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd08215  239 LQKDPEKRPSANEILS 254
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
282-530 2.52e-67

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 218.88  E-value: 2.52e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05117    1 KYELGKVLGRGSFGVVRLAVHKKTGEEYAVKIIDKKKLKSEdeEMLRREIEILKRLDHPNIVKLYEVFEDDKNLYLVMEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFcAQITPEQSKRS 435
Cdd:cd05117   81 CTGGELFDrIVKKGSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLaskDPDSPIKIIDFGL-AKIFEEGEKLK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPE--RLSAVFRDFLNR 513
Cdd:cd05117  160 TVCGTPYYVAPEVLKGKGYGKKCDIWSLGVILYILLCGYPPFYGETEQELFEKI-LKGKYSFDSPEwkNVSEEAKDLIKR 238
                        250
                 ....*....|....*..
gi 578838380 514 CLEMDVDRRGSAKELLQ 530
Cdd:cd05117  239 LLVVDPKKRLTAAEALN 255
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
278-529 9.31e-67

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 217.59  E-value: 9.31e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06646    6 NPQHDYELIQRVGSGTYGDVYKARNLHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06646   86 EYCGGGSLQDIYHVTGpLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKRKS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFL 511
Cdd:cd06646  166 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFV 245
                        250
                 ....*....|....*...
gi 578838380 512 NRCLEMDVDRRGSAKELL 529
Cdd:cd06646  246 KISLTKNPKKRPTAERLL 263
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
282-534 9.66e-67

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 217.45  E-value: 9.66e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI---INEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14014    1 RYRLVRLLGRGGMGEVYRARDTLLGRPVAIKVLRPELAEDEEFRerfLREARALARLSHPNIVRVYDVGEDDGRPYIVME 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd14014   81 YVEGGSLADLLRErGPLPPREALRILAQIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALGDSGLTQTGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 V-GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQNPERLSAVFRDFLNRCL 515
Cdd:cd14014  161 VlGTPAYMAPEQARGGPVDPRSDIYSLGVVLYELLTGRPPFDGDSPAAVLAKHLQEaPPPPSPLNPDVPPALDAIILRAL 240
                        250       260
                 ....*....|....*....|
gi 578838380 516 EMDVDRR-GSAKELLQVLLA 534
Cdd:cd14014  241 AKDPEERpQSAAELLAALRA 260
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
271-530 1.82e-66

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 217.57  E-value: 1.82e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 271 RSIV--SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348
Cdd:cd06638    6 KTIIfdSFPDPSDTWEIIETIGKGTYGKVFKVLNKKNGSKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVKFYGMYY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 349 -----VGDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKL 418
Cdd:cd06638   86 kkdvkNGDQLWLVLELCNGGSVTDLVKGFLkrgerMEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNILLTTEGGVKL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 419 TDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG 493
Cdd:cd06638  166 VDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIAceqqlDSTYDARCDVWSLGITAIELGDGDPPLADLHPMRALFKIPRNP 245
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 578838380 494 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06638  246 PPTLHQPELWSNEFNDFIRKCLTKDYEKRPTVSDLLQ 282
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
282-539 6.79e-66

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 222.20  E-value: 6.79e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:COG0515    8 RYRILRLLGRGGMGVVYLARDLRLGRPVALKVLRpeLAADPEaRERFRREARALARLNHPNIVRVYDVGEEDGRPYLVME 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-T 436
Cdd:COG0515   88 YVEGESLADLLRRRgPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTgT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQNPERLSAVFRDFLNRCL 515
Cdd:COG0515  168 VVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLTGRPPFDGDSPAELLRAHLREpPPPPSELRPDLPPALDAIVLRAL 247
                        250       260
                 ....*....|....*....|....*
gi 578838380 516 EMDVDRR-GSAKELLQVLLAGGNSL 539
Cdd:COG0515  248 AKDPEERyQSAAELAAALRAVLRSL 272
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
278-530 1.44e-64

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 212.21  E-value: 1.44e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06645    8 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHSNIVAYFGSYLRRDKLWICM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd06645   88 EFCGGGSLQDIYHVTGpLSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFL 511
Cdd:cd06645  168 FIGTPYWMAPEVaaVERKgGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFV 247
                        250
                 ....*....|....*....
gi 578838380 512 NRCLEMDVDRRGSAKELLQ 530
Cdd:cd06645  248 KMALTKNPKKRPTAEKLLQ 266
Pkinase pfam00069
Protein kinase domain;
283-530 4.43e-64

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 208.64  E-value: 4.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKKKDknILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  361 AGGSLTDVVTE-TCMDEGQIAAVCREclqaldflhsnqvihrdiksdnILLGMDGSVKLTDFgfcaqitpeqskrstmVG 439
Cdd:pfam00069  81 EGGSLFDLLSEkGAFSEREAKFIMKQ----------------------ILEGLESGSSLTTF----------------VG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:pfam00069 123 TPWYMAPEVLGGNPYGPKVDVWSLGCILYELLTGKPPFPGINGNEIYELIIDQPYAFPELPSNLSEEAKDLLKKLLKKDP 202
                         250
                  ....*....|.
gi 578838380  520 DRRGSAKELLQ 530
Cdd:pfam00069 203 SKRLTATQALQ 213
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
288-530 1.20e-63

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 209.37  E-value: 1.20e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQP-KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd06623    8 VLGQGSSGVVYKVRHKPTGKIYALKKIHVDGDEeFRKQLLRELKTLRSCESPYVVKCYGAFYKEGEISIVLEYMDGGSLA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTET-CMDEGQIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 444
Cdd:cd06623   88 DLLKKVgKIPEPVLAYIARQILKGLDYLHTKrHIIHRDIKPSNLLINSKGEVKIADFGISKVLENTLDQCNTFVGTVTYM 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR--ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd06623  168 SPERIQGESYSYAADIWSLGLTLLECALGKFPFLPPGQPSffELMQAICDGPPPSLPAEEFSPEFRDFISACLQKDPKKR 247

                 ....*...
gi 578838380 523 GSAKELLQ 530
Cdd:cd06623  248 PSAAELLQ 255
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
278-530 1.54e-63

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 210.27  E-value: 1.54e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd06644    9 DPNEVWEIIGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYMVEIEILATCNHPYIVKLLGAFYWDGKLWIMI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTEtcMDEG----QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
Cdd:cd06644   89 EFCPGGAVDAIMLE--LDRGltepQIQVICRQMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVSAKNVKTLQR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 RSTMVGTPYWMAPEVV---TRK--AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFR 508
Cdd:cd06644  167 RDSFIGTPYWMAPEVVmceTMKdtPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLSQPSKWSMEFR 246
                        250       260
                 ....*....|....*....|..
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06644  247 DFLKTALDKHPETRPSAAQLLE 268
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
273-530 9.19e-63

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 207.55  E-value: 9.19e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 273 IVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--- 349
Cdd:cd06636    8 LSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKksp 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 350 ---GDELWVVMEYLAGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd06636   88 pghDDQLWLVMEFCGAGSVTDLVKNTkgnALKEDWIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 CAQITPEQSKRSTMVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ 498
Cdd:cd06636  168 SAQLDRTVGRRNTFIGTPYWMAPEVIAcdenpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLK 247
                        250       260       270
                 ....*....|....*....|....*....|..
gi 578838380 499 NpERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06636  248 S-KKWSKKFIDFIEGCLVKNYLSRPSTEQLLK 278
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
288-530 8.02e-62

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 204.46  E-value: 8.02e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQ--QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd06626    7 KIGEGTFGKVYTAVNLDTGELMAMKEIRFQdnDPKTIKEIADEMKVLEGLDHPNLVRYYGVEVHREEVYIFMEYCQEGTL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfCAQI------TPEQSKRSTMV 438
Cdd:cd06626   87 EELLRHGRIlDEAVIRVYTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFG-SAVKlknnttTMAPGEVNSLV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVT---RKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd06626  166 GTPAYMAPEVITgnkGEGHGRAADIWSLGCVVLEMATGKRPWSElDNEWAIMYHVGMGHKPPIPDSLQLSPEGKDFLSRC 245
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd06626  246 LESDPKKRPTASELLD 261
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
289-529 1.72e-61

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 203.36  E-value: 1.72e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd06625    8 LGQGAFGQVYLCYDADTGRELAVKQVEIDPintEASKEVKAleCEIQLLKNLQHERIVQYYGCLQDEKSLSIFMEYMPGG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpeQSKRS-----TM 437
Cdd:cd06625   88 SVKDEIKAYgALTENVTRKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKRL---QTICSstgmkSV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELqnPERLSAVFRDFLNRCLE 516
Cdd:cd06625  165 TGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTTKPPWAEFEPMAAIFKIATQPTnPQL--PPHVSEDARDFLSLIFV 242
                        250
                 ....*....|...
gi 578838380 517 MDVDRRGSAKELL 529
Cdd:cd06625  243 RNKKQRPSAEELL 255
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
278-530 3.32e-61

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 204.50  E-value: 3.32e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06633   18 DPEEIFVDLHEIGHGSFGAVYFATNSHTNEVVAIKKMSYsgkQTNEKWQDIIKEVKFLQQLKHPNTIEYKGCYLKDHTAW 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGgSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd06633   98 LVMEYCLG-SASDLleVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 krstMVGTPYWMAPEVV---TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFRD 509
Cdd:cd06633  177 ----FVGTPYWMAPEVIlamDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNE-WTDSFRG 251
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06633  252 FVDYCLQKIPQERPSSAELLR 272
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
275-530 1.71e-60

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 202.14  E-value: 1.71e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKElIINEILVMRENKN-PNIVN-----YLDSYL 348
Cdd:cd06639   16 SLADPSDTWDIIETIGKGTYGKVYKVTNKKDGSLAAVKILDPISDVDEE-IEAEYNILRSLPNhPNVVKfygmfYKADQY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 349 VGDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd06639   95 VGGQLWLVLELCNGGSVTELVKGLLkcgqrLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 CAQITPEQSKRSTMVGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ 498
Cdd:cd06639  175 SAQLTSARLRRNTSVGTPFWMAPEVIACEqqydySYDARCDVWSLGITAIELADGDPPLFDMHPVKALFKIPRNPPPTLL 254
                        250       260       270
                 ....*....|....*....|....*....|..
gi 578838380 499 NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06639  255 NPEKWCRGFSHFISQCLIKDFEKRPSVTHLLE 286
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
286-530 4.06e-60

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 199.62  E-value: 4.06e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FE---KIGQGASGTVYTALDIATGQEVAIKQM---NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14007    2 FEigkPLGKGKFGNVYLAREKKSGFIVALKVIsksQLQKSGLEHQLRREIEIQSHLRHPNILRLYGYFEDKKRIYLILEY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPeqSKRSTMV 438
Cdd:cd14007   82 APNGELyKELKKQKRFDEKEAAKYIYQLALALDYLHSKNIIHRDIKPENILLGSNGELKLADFGWSVHAPS--NRRKTFC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAtngTPELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd14007  160 GTLDYLPPEMVEGKEYDYKVDIWSLGVLCYELLVGKPPFESKSHQETYKRIQ---NVDIKFPSSVSPEAKDLISKLLQKD 236
                        250
                 ....*....|..
gi 578838380 519 VDRRGSAKELLQ 530
Cdd:cd14007  237 PSKRLSLEQVLN 248
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
282-529 4.24e-59

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 197.24  E-value: 4.24e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-----ELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd06632    1 RWQKGQLLGSGSFGSVYEGFNGDTGDFFAVKEVSLVDDDKKsresvKQLEQEIALLSKLRHPNIVQYYGTEREEDNLYIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpEQSKRS 435
Cdd:cd06632   81 LEYVPGGSIHKLLQRyGAFEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGMAKHVE-AFSFAK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRK--AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG-TPELqnPERLSAVFRDFLN 512
Cdd:cd06632  160 SFKGSPYWMAPEVIMQKnsGYGLAVDIWSLGCTVLEMATGKPPWSQYEGVAAIFKIGNSGeLPPI--PDHLSPDAKDFIR 237
                        250
                 ....*....|....*..
gi 578838380 513 RCLEMDVDRRGSAKELL 529
Cdd:cd06632  238 LCLQRDPEDRPTASQLL 254
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
289-528 4.56e-59

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 196.58  E-value: 4.56e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNlqqqpKKELI--------INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd05123    1 LGKGSFGKVLLVRKKDTGKLYAMKVLR-----KKEIIkrkevehtLNERNILERVNHPFIVKLHYAFQTEEKLYLVLDYV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:cd05123   76 PGGELFSHLsKEGRFPEERARFYAAEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKELSSDGDRTYTFCG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:cd05123  156 TPEYLAPEVLLGKGYGKAVDWWSLGVLLYEMLTGKPPFYAENRKEIYEKILKS---PLKFPEYVSPEAKSLISGLLQKDP 232
                        250
                 ....*....|..
gi 578838380 520 DRR---GSAKEL 528
Cdd:cd05123  233 TKRlgsGGAEEI 244
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
287-530 1.23e-58

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 195.81  E-value: 1.23e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14003    6 KTLGEGSFGKVKLARHKLTGEKVAIKIIDKSKLKEEieEKIKREIEIMKLLNHPNIIKLYEVIETENKIYLVMEYASGGE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEqSKRSTMVGTPYW 443
Cdd:cd14003   86 LFDyIVNNGRLSEDEARRFFQQLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFRGG-SLLKTFCGTPAY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd14003  165 AAPEVLLGRKYdGPKADVWSLGVILYAMLTGYLPFDDDN-DSKLFRKILKGKYPI--PSHLSPDARDLIRRMLVVDPSKR 241

                 ....*...
gi 578838380 523 GSAKELLQ 530
Cdd:cd14003  242 ITIEEILN 249
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
278-530 1.79e-58

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 197.58  E-value: 1.79e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06635   22 DPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYsgkQSNEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAW 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGgSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd06635  102 LVMEYCLG-SASDLleVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANS 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 krstMVGTPYWMAPEVV---TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFRD 509
Cdd:cd06635  181 ----FVGTPYWMAPEVIlamDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-WSDYFRN 255
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06635  256 FVDSCLQKIPQDRPTSEELLK 276
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
289-532 2.70e-57

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 191.98  E-value: 2.70e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTAldIATGQEVAIKQMNLQ--QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd13999    1 IGSGSFGEVYKG--KWRGTDVAIKKLKVEddNDELLKEFRREVSILSKLRHPNIVQFIGACLSPPPLCIVTEYMPGGSLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 444
Cdd:cd13999   79 DLLHKkkIPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKNSTTEKMTGVVGTPRWM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPeLQNPERLSAVFRDFLNRCLEMDVDRRGS 524
Cdd:cd13999  159 APEVLRGEPYTEKADVYSFGIVLWELLTGEVPFKELSPIQIAAAVVQKGLR-PPIPPDCPPELSKLIKRCWNEDPEKRPS 237

                 ....*...
gi 578838380 525 AKELLQVL 532
Cdd:cd13999  238 FSEIVKRL 245
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
278-530 8.04e-57

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 192.63  E-value: 8.04e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL------VGD 351
Cdd:cd06637    3 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIkknppgMDD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd06637   83 QLWLVMEFCGAGSVTDLIKNTkgnTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQSKRSTMVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpERL 503
Cdd:cd06637  163 RTVGRRNTFIGTPYWMAPEVIAcdenpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKW 241
                        250       260
                 ....*....|....*....|....*..
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06637  242 SKKFQSFIESCLVKNHSQRPSTEQLMK 268
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
283-530 8.24e-57

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 191.50  E-value: 8.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALdIATGQEVAIKQMNL--------QQQPKKelIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06631    3 WKKGNVLGKGAYGTVYCGL-TSTGQLIAVKQVELdtsdkekaEKEYEK--LQEEVDLLKTLKHVNIVGYLGTCLEDNVVS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfCAQITPEQSK 433
Cdd:cd06631   80 IFMEFVPGGSIASILARfGALEEPVFCRYTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFG-CAKRLCINLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 RST-------MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAV 506
Cdd:cd06631  159 SGSqsqllksMRGTPYWMAPEVINETGHGRKSDIWSIGCTVFEMATGKPPWADMNPMAAIFAIGSGRKPVPRLPDKFSPE 238
                        250       260
                 ....*....|....*....|....
gi 578838380 507 FRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06631  239 ARDFVHACLTRDQDERPSAEQLLK 262
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
282-529 1.51e-55

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 188.13  E-value: 1.51e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELI---INEILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd06628    1 KWIKGALIGSGSFGSVYLGMNASSGELMAVKQVELpsvsaeNKDRKKSMLdalQREIALLRELQHENIVQYLGSSSDANH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI---- 427
Cdd:cd06628   81 LNIFLEYVPGGSVATLLNNyGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLeans 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 --TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqnPERLSA 505
Cdd:cd06628  161 lsTKNNGARPSLQGSVFWMAPEVVKQTSYTRKADIWSLGCLVVEMLTGTHPFPDCTQMQAIFKIGENASPTI--PSNISS 238
                        250       260
                 ....*....|....*....|....
gi 578838380 506 VFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd06628  239 EARDFLEKTFEIDHNKRPTADELL 262
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
278-530 8.66e-55

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 187.54  E-value: 8.66e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 354
Cdd:cd06634   12 DPEKLFSDLREIGHGSFGAVYFARDVRNNEVVAIKKMSYsgkQSNEKWQDIIKEVKFLQKLRHPNTIEYRGCYLREHTAW 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGgSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd06634   92 LVMEYCLG-SASDLleVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAPANS 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 krstMVGTPYWMAPEVV---TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpERLSAVFRD 509
Cdd:cd06634  171 ----FVGTPYWMAPEVIlamDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQS-GHWSEYFRN 245
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06634  246 FVDSCLQKIPQDRPTSDVLLK 266
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
282-531 8.78e-55

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 185.82  E-value: 8.78e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSYLVGDE--LWVVM 357
Cdd:cd08217    1 DYEVLETIGKGSFGTVRKVRRKSDGKILVWKEIDYGKmsEKEKQQLVSEVNILRELKHPNIVRYYDRIVDRANttLYIVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-----TETCMDEGQIAAVCRECLQALDFLH-----SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 427
Cdd:cd08217   81 EYCEGGDLAQLIkkckkENQYIPEEFIWKIFTQLLLALYECHnrsvgGGKILHRDLKPANIFLDSDNNVKLGDFGLARVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqnPERLSAVF 507
Cdd:cd08217  161 SHDSSFAKTYVGTPYYMSPELLNEQSYDEKSDIWSLGCLIYELCALHPPFQAANQLELAKKIKEGKFPRI--PSRYSSEL 238
                        250       260
                 ....*....|....*....|....
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQV 531
Cdd:cd08217  239 NEVIKSMLNVDPDKRPSVEELLQL 262
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
282-530 2.91e-53

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 181.68  E-value: 2.91e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14002    2 NYHVLELIGEGSFGKVYKGRRKYTGQVVALKFIPKRGKSEKELrnLRQEIEILRKLNHPNIIEMLDSFETKKEFVVVTEY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 lAGGSLTDVVT-ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeqskRSTMV 438
Cdd:cd14002   82 -AQGELFQILEdDGTLPEEEVRSIAKQLVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMS-----CNTLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 -----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNR 513
Cdd:cd14002  156 ltsikGTPLYMAPELVQEQPYDHTADLWSLGCILYELFVGQPPFYTNSIYQLVQMIVKD---PVKWPSNMSPEFKSFLQG 232
                        250
                 ....*....|....*..
gi 578838380 514 CLEMDVDRRGSAKELLQ 530
Cdd:cd14002  233 LLNKDPSKRLSWPDLLE 249
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
289-530 2.06e-52

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 179.91  E-value: 2.06e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQM---NLQQ-QPKKEliinEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd06624   16 LGKGTFGVVYAARDLSTQVRIAIKEIperDSREvQPLHE----EIALHSRLSHKNIVQYLGSVSEDGFFKIFMEQVPGGS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTET----CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:cd06624   92 LSALLRSKwgplKDNENTIGYYTKQILEGLKYLHDNKIVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGINPCTETFTG 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATNGT-PELqnPERLSAVFRDFLNRCL 515
Cdd:cd06624  172 TLQYMAPEVIDKgqRGYGPPADIWSLGCTIIEMATGKPPFIELgEPQAAMFKVGMFKIhPEI--PESLSEEAKSFILRCF 249
                        250
                 ....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQ 530
Cdd:cd06624  250 EPDPDKRATASDLLQ 264
KIND smart00750
kinase non-catalytic C-lobe domain; It is an interaction domain identified as being similar to ...
363-534 4.16e-51

kinase non-catalytic C-lobe domain; It is an interaction domain identified as being similar to the C-terminal protein kinase catalytic fold (C lobe). Its presence at the N terminus of signalling proteins and the absence of the active-site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of KIND only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features


Pssm-ID: 214801  Cd Length: 176  Bit Score: 172.97  E-value: 4.16e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   363 GSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQvihrdiKSDNILLGMDGSVKLtdFGFCAQITPEQSKrstmvGT 440
Cdd:smart00750   1 VSLADILEvrGRPLNEEEIWAVCLQCLGALRELHRQA------KSGNILLTWDGLLKL--DGSVAFKTPEQSR-----PD 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL-----QNPERLSA--VFRDFLNR 513
Cdd:smart00750  68 PYFMAPEVIQGQSYTEKADIYSLGITLYEALDYELPYNEERELSAILEILLNGMPADdprdrSNLEGVSAarSFEDFMRL 147
                          170       180
                   ....*....|....*....|.
gi 578838380   514 CLEMDVDRRGSAKELLQVLLA 534
Cdd:smart00750 148 CASRLPQRREAANHYLAHCRA 168
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
289-530 7.90e-50

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 172.74  E-value: 7.90e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN-----------LQQQPKK---ELIINEILVMRENKNPNIVN-Y--LDSyLVGD 351
Cdd:cd14008    1 LGRGSFGKVKLALDTETGQLYAIKIFNksrlrkrregkNDRGKIKnalDDVRREIAIMKKLDHPNIVRlYevIDD-PESD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG---FCA 425
Cdd:cd14008   80 KLYLVLEYCEGGPVMELDSGDrvpPLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGvseMFE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSKRstmVGTPYWMAPEV--VTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLrALYLIATNGTPELQNPER 502
Cdd:cd14008  160 DGNDTLQKT---AGTPAFLAPELcdGDSKTYsGKAADIWALGVTLYCLVFGRLPFNGDNIL-ELYEAIQNQNDEFPIPPE 235
                        250       260
                 ....*....|....*....|....*...
gi 578838380 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14008  236 LSPELKDLLRRMLEKDPEKRITLKEIKE 263
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
282-530 1.14e-49

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 172.57  E-value: 1.14e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL------QQQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGD 351
Cdd:cd06629    2 KWVKGELIGKGTYGRVYLAMNATTGEMLAVKQVELpktssdRADSRQKTVVDalksEIDTLKDLDHPNIVQYLGFEETED 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcaqitpe 430
Cdd:cd06629   82 YFSIFLEYVPGGSIGSCLrKYGKFEEDLVRFFTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGI------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 qSKRS----------TMVGTPYWMAPEVV--TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPEL 497
Cdd:cd06629  155 -SKKSddiygnngatSMQGSVFWMAPEVIhsQGQGYSAKVDIWSLGCVVLEMLAGRRPWSDDEAIAAMFKLgNKRSAPPV 233
                        250       260       270
                 ....*....|....*....|....*....|...
gi 578838380 498 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06629  234 PEDVNLSPEALDFLNACFAIDPRDRPTAAELLS 266
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
289-422 9.05e-49

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 165.31  E-value: 9.05e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNP--NIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd13968    1 MGEGASAKVFWAEGECTTIGVAVKIGDDVNNEEGEDLESEMDILRRLKGLelNIPKVLVTEDVDGPNILLMELVKGGTLI 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 367 DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Cdd:cd13968   81 AYTQEEELDEKDVESIMYQLAECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
282-529 4.29e-48

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 167.79  E-value: 4.29e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRF-EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVM- 357
Cdd:cd13983    1 RYLKFnEVLGRGSFKTVYRAFDTEEGIEVAWNEIKLRKLPKAERqrFKQEIEILKSLKHPNIIKFYDSWESKSKKEVIFi 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 -EYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQItpEQS 432
Cdd:cd13983   81 tELMTSGTLKQYLKRfKRLKLKVIKSWCRQILEGLNYLHTRDppIIHRDLKCDNIFInGNTGEVKIGDLGLATLL--RQS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMVGTPYWMAPEVVTRKaYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPelqnPERLSAV----FR 508
Cdd:cd13983  159 FAKSVIGTPEFMAPEMYEEH-YDEKVDIYAFGMCLLEMATGEYPYSECTNAAQIYKKVTSGIK----PESLSKVkdpeLK 233
                        250       260
                 ....*....|....*....|.
gi 578838380 509 DFLNRCLEmDVDRRGSAKELL 529
Cdd:cd13983  234 DFIEKCLK-PPDERPSARELL 253
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
287-530 6.44e-48

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 167.59  E-value: 6.44e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd08529    6 NKLGKGSFGVVYKVVRKVDGRVYALKQIDISRMSRkmREEAIDEARVLSKLNSPYVIKYYDSFVDKGKLNIVMEYAENGD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441
Cdd:cd08529   86 LHSLIKSQRgrpLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDTTNFAQTIVGTP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqnPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd08529  166 YYLSPELCEDKPYNEKSDVWALGCVLYELCTGKHPFEAQNQGALILKIVRGKYPPI--SASYSQDLSQLIDSCLTKDYRQ 243

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd08529  244 RPDTTELLR 252
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
283-530 1.99e-47

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 166.89  E-value: 1.99e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpkKELI----INEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd07829    1 YEKLEKLGEGTYGVVYKAKDKKTGEIVALKKIRLDNE--EEGIpstaLREISLLKELKHPNIVKLLDVIHTENKLYLVFE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAggslTDV-----VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
Cdd:cd07829   79 YCD----QDLkkyldKRPGPLPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARAFGIPLRT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 RSTMVGTPYWMAPEVVTR-KAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTPELQN----------- 499
Cdd:cd07829  155 YTHEVVTLWYRAPEILLGsKHYSTAVDIWSVGcIFA-ELITGKPLFPGDSEIDQLFKIfQILGTPTEESwpgvtklpdyk 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 500 -------PERLSAVF-------RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07829  234 ptfpkwpKNDLEKVLprldpegIDLLSKMLQYNPAKRISAKEALK 278
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
282-530 5.94e-47

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 165.95  E-value: 5.94e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd07833    2 KYEVLGVVGEGAYGVVLKCRNKATGEIVAIKKFKESEDDEdvKKTALREVKVLRQLRHENIVNLKEAFRRKGRLYLVFEY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LaGGSLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-PEQSKRST 436
Cdd:cd07833   82 V-ERTLLELLEAspGGLPPDAVRSYIWQLLQAIAYCHSHNIIHRDIKPENILVSESGVLKLCDFGFARALTaRPASPLTD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEV-VTRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI---------------------ATNG 493
Cdd:cd07833  161 YVATRWYRAPELlVGDTNYGKPVDVWAIGcIMA-ELLDGEPLFPGDSDIDQLYLIqkclgplppshqelfssnprfAGVA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 494 TPELQNPERLSAVFR--------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07833  240 FPEPSQPESLERRYPgkvsspalDFLKACLRMDPKERLTCDELLQ 284
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
289-528 2.43e-46

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 163.54  E-value: 2.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQM--------NLQQQPKKEliiNEILVMreNKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd05579    1 ISRGAYGRVYLAKKKSTGDLYAIKVIkkrdmirkNQVDSVLAE---RNILSQ--AQNPFVVKLYYSFQGKKNLYLVMEYL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGG---SLTDVVTetCMDEgQIAAVC-RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF------------- 423
Cdd:cd05579   76 PGGdlySLLENVG--ALDE-DVARIYiAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGLskvglvrrqikls 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 --CAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGTPELQNPE 501
Cdd:cd05579  153 iqKKSNGAPEKEDRRIVGTPDYLAPEILLGQGHGKTVDWWSLGVILYEFLVGIPPFHAETP-EEIFQNILNGKIEWPEDP 231
                        250       260       270
                 ....*....|....*....|....*....|
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRR---GSAKEL 528
Cdd:cd05579  232 EVSDEAKDLISKLLTPDPEKRlgaKGIEEI 261
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
283-530 3.66e-46

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 162.98  E-value: 3.66e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL------IINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd06630    2 WLKGPLLGTGAFSSCYQARDVKTGTLMAVKQVSFCRNSSSEQeevveaIREEIRMMARLNHPNIVRMLGATQHKSHFNIF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSK- 433
Cdd:cd06630   82 VEWMAGGSVASLLSKyGAFSENVIINYTLQILRGLAYLHDNQIIHRDLKGANLLVDSTGQrLRIADFGAAARLASKGTGa 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 ---RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIAT-NGTPELqnPERLSAV 506
Cdd:cd06630  162 gefQGQLLGTIAFMAPEVLRGEQYGRSCDVWSVGCVIIEMATAKPPWNAEkisNHLALIFKIASaTTPPPI--PEHLSPG 239
                        250       260
                 ....*....|....*....|....
gi 578838380 507 FRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06630  240 LRDVTLRCLELQPEDRPPARELLK 263
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
289-530 6.56e-46

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 162.51  E-value: 6.56e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE-LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd06605    9 LGEGNGGVVSKVRHRPSGQIMAVKVIRLEIDEALQkQILRELDVLHKCNSPYIVGFYGAFYSEGDISICMEYMDGGSLDK 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTET-CMDEGQIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRSTMVGTPYWMA 445
Cdd:cd06605   89 ILKEVgRIPERILGKIAVAVVKGLIYLHEKhKIIHRDVKPSNILVNSRGQVKLCDFGVSGQLV--DSLAKTFVGTRSYMA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 446 PEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN------PLRALYLIATNGTPELQNpERLSAVFRDFLNRCLEMDV 519
Cdd:cd06605  167 PERISGGKYTVKSDIWSLGLSLVELATGRFPYPPPNakpsmmIFELLSYIVDEPPPLLPS-GKFSPDFQDFVSQCLQKDP 245
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd06605  246 TERPSYKELME 256
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
287-532 8.39e-46

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 161.93  E-value: 8.39e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   287 EKIGQGASGTVY----TALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:smart00219   5 KKLGEGAFGEVYkgklKGKGGKKKVEVAVKTLKEDASEQqIEEFLREARIMRKLDHPNVVKLLGVCTEEEPLYIVMEYME 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   362 GGSLTDVVTET----CMDE-----GQIAAvcreclqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:smart00219  85 GGDLLSYLRKNrpklSLSDllsfaLQIAR-------GMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDY 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   433 KRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTPELqnPERLSAVFRDF 510
Cdd:smart00219 158 YRKRGGKLPIrWMAPESLKEGKFTSKSDVWSFGVLLWEIFTlGEQPYPGMSNEEVLEYLKNGYRLPQ--PPNCPPELYDL 235
                          250       260
                   ....*....|....*....|..
gi 578838380   511 LNRCLEMDVDRRGSAKELLQVL 532
Cdd:smart00219 236 MLQCWAEDPEDRPTFSELVEIL 257
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
287-532 3.99e-45

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 160.02  E-value: 3.99e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   287 EKIGQGASGTVY----TALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:smart00221   5 KKLGEGAFGEVYkgtlKGKGDGKEVEVAVKTLKEDASEQqIEEFLREARIMRKLDHPNIVKLLGVCTEEEPLMIVMEYMP 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   362 GGSLTDVVTETCMDEGQIAAVCRECLQA---LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:smart00221  85 GGDLLDYLRKNRPKELSLSDLLSFALQIargMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYKVKGG 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380   439 GTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTPELqnPERLSAVFRDFLNRCLE 516
Cdd:smart00221 165 KLPIrWMAPESLKEGKFTSKSDVWSFGVLLWEIFTlGEEPYPGMSNAEVLEYLKKGYRLPK--PPNCPPELYKLMLQCWA 242
                          250
                   ....*....|....*.
gi 578838380   517 MDVDRRGSAKELLQVL 532
Cdd:smart00221 243 EDPEDRPTFSELVEIL 258
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
289-522 9.39e-45

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 158.92  E-value: 9.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14009    1 IGRGSFATVWKGRHKQTGEVVAIKEISRKKLNKKlqENLESEIAILKSIKHPNIVRLYDVQKTEDFIYLVLEYCAGGDLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVV-TETCMDEgqiaAVCRECLQ----ALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFcAQITPEQSKRSTMV 438
Cdd:cd14009   81 QYIrKRGRLPE----AVARHFMQqlasGLKFLRSKNIIHRDLKPQNLLLstsGDDPVLKIADFGF-ARSLQPASMAETLC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRDFLNRCLEM 517
Cdd:cd14009  156 GSPLYMAPEILQFQKYDAKADLWSVGAILFEMLVGKPPFRGSNHVQLLRNIeRSDAVIPFPIAAQLSPDCKDLLRRLLRR 235

                 ....*
gi 578838380 518 DVDRR 522
Cdd:cd14009  236 DPAER 240
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
282-530 2.09e-44

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 159.07  E-value: 2.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQ-MNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd07847    2 KYEKLSKIGEGSYGVVFKCRNRETGQIVAIKKfVESEDDPViKKIALREIRMLKQLKHPNLVNLIEVFRRKRKLHLVFEY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd07847   82 CDHTVLNELEKNPrGVPEHLIKKIIWQTLQAVNFCHKHNCIHRDVKPENILITKQGQIKLCDFGFARILTGPGDDYTDYV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPE-VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI---------------ATNG------TPE 496
Cdd:cd07847  162 ATRWYRAPElLVGDTQYGPPVDVWAIGCVFAELLTGQPLWPGKSDVDQLYLIrktlgdliprhqqifSTNQffkglsIPE 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 497 LQNPERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07847  242 PETREPLESKFPnisspalSFLKGCLQMDPTERLSCEELLE 282
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
288-531 4.77e-44

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 157.17  E-value: 4.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNL--QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd08530    7 KLGKGSYGSVYKVKRLSDNQVYALKEVNLgsLSQKEREDSVNEIRLLASVNHPNIIRYKEAFLDGNRLCIVMEYAPFGDL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVV-----TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKrsTMVGT 440
Cdd:cd08530   87 SKLIskrkkKRRLFPEDDIWRIFIQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKVLKKNLAK--TQIGT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYLIATNGT-PELqnPERLSAVFRDFLNRCLEMDV 519
Cdd:cd08530  165 PLYAAPEVWKGRPYDYKSDIWSLGCLLYEMATFRPPF-EARTMQELRYKVCRGKfPPI--PPVYSQDLQQIIRSLLQVNP 241
                        250
                 ....*....|..
gi 578838380 520 DRRGSAKELLQV 531
Cdd:cd08530  242 KKRPSCDKLLQS 253
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
281-530 5.42e-44

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 156.95  E-value: 5.42e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIK---QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14099    1 KRYRRGKFLGKGGFAKCYEVTDMSTGKVYAGKvvpKSSLTKPKQREKLKSEIKIHRSLKHPNIVKFHDCFEDEENVYILL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd14099   81 ELCSNGSLMELLkRRKALTEPEVRYFMRQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAARLEYDGERKKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRK-AYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYL-IATNgtpELQNPERL--SAVFRDFLN 512
Cdd:cd14099  161 LCGTPNYIAPEVLEKKkGHSFEVDIWSLGVILYTLLVGKPPF-ETSDVKETYKrIKKN---EYSFPSHLsiSDEAKDLIR 236
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14099  237 SMLQPDPTKRPSLDEILS 254
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
287-522 1.39e-43

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 156.61  E-value: 1.39e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd05581    7 KPLGEGSYSTVVLAKEKETGKEYAIKVLDkrhIIKEKKVKYVTIEKEVLSRLAHPGIVKLYYTFQDESKLYFVLEYAPNG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG----FCA------------- 425
Cdd:cd05581   87 DLLEYIRKyGSLDEKCTRFYTAEIVLALEYLHSKGIIHRDLKPENILLDEDMHIKITDFGtakvLGPdsspestkgdads 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGtpELQNPERLSA 505
Cdd:cd05581  167 QIAYNQARAASFVGTAEYVSPELLNEKPAGKSSDLWALGCIIYQMLTGKPPFRGSNEYLTFQKI-VKL--EYEFPENFPP 243
                        250
                 ....*....|....*..
gi 578838380 506 VFRDFLNRCLEMDVDRR 522
Cdd:cd05581  244 DAKDLIQKLLVLDPSKR 260
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
288-530 1.55e-43

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 155.49  E-value: 1.55e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14081    8 TLGKGQTGLVKLAKHCVTGQKVAIKIVNKEKLSKESVlmkVEREIAIMKLIEHPNVLKLYDVYENKKYLYLVLEYVSGGE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYW 443
Cdd:cd14081   88 LFDyLVKKGRLTEKEARKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGM-ASLQPEGSLLETSCGSPHY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd14081  167 ACPEVIKGEKYdGRKADIWSCGVILYALLVGALPFDDDN-LRQLLEKVKRGVFHI--PHFISPDAQDLLRRMLEVNPEKR 243

                 ....*...
gi 578838380 523 GSAKELLQ 530
Cdd:cd14081  244 ITIEEIKK 251
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
286-522 2.23e-43

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 156.20  E-value: 2.23e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd05580    6 LKTLGTGSFGRVRLVKHKDSGKYYALKILKKAKiikLKQVEHVLNEKRILSEVRHPFIVNLLGSFQDDRNLYMVMEYVPG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPeqsKRSTMVGTP 441
Cdd:cd05580   86 GELfSLLRRSGRFPNDVAKFYAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRVKD---RTYTLCGTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGtpELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd05580  163 EYLAPEIILSKGHGKAVDWWALGILIYEMLAGYPPFFDENPMK-IYEKILEG--KIRFPSFFDPDAKDLIKRLLVVDLTK 239

                 .
gi 578838380 522 R 522
Cdd:cd05580  240 R 240
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
283-530 3.05e-43

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 154.70  E-value: 3.05e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMnLQQQPKKELIINEILVMRE----NKNPNIVNYLDSYL--VGDELWVV 356
Cdd:cd05118    1 YEVLRKIGEGAFGTVWLARDKVTGEKVAIKKI-KNDFRHPKAALREIKLLKHlndvEGHPNIVKLLDVFEhrGGNHLCLV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLaGGSLTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSk 433
Cdd:cd05118   80 FELM-GMNLYELIkdYPRGLPLDLIKSYLYQLLQALDFLHSNGIIHRDLKPENILInLELGQLKLADFGLARSFTSPPY- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 rSTMVGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPElqnperlsavFRDFL 511
Cdd:cd05118  158 -TPYVATRWYRAPEVlLGAKPYGSSIDIWSLGCILAELLTGRPLFPGDSEVDQLAKIvRLLGTPE----------ALDLL 226
                        250
                 ....*....|....*....
gi 578838380 512 NRCLEMDVDRRGSAKELLQ 530
Cdd:cd05118  227 SKMLKYDPAKRITASQALA 245
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
282-530 3.18e-43

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 154.79  E-value: 3.18e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14095    1 KYDIGRVIGDGNFAVVKECRDKATDKEYALKIIDKAKcKGKEHMIENEVAILRRVKHPNIVQLIEEYDTDTELYLVMELV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG----SVKLTDFGFcAQITPEQSkrS 435
Cdd:cd14095   81 KGGDLFDAITSSTkFTERDASRMVTDLAQALKYLHSLSIVHRDIKPENLLVVEHEdgskSLKLADFGL-ATEVKEPL--F 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA-LYLIATNGTPELQNP--ERLSAVFRDFLN 512
Cdd:cd14095  158 TVCGTPTYVAPEILAETGYGLKVDIWAAGVITYILLCGFPPFRSPDRDQEeLFDLILAGEFEFLSPywDNISDSAKDLIS 237
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14095  238 RMLVVDPEKRYSAGQVLD 255
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
289-530 4.47e-43

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 154.80  E-value: 4.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQ---QQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDE--LWVVMEYLA 361
Cdd:cd06653   10 LGRGAFGEVYLCYDADTGRELAVKQVPFDpdsQETSKEVnaLECEIQLLKNLRHDRIVQYYGCLRDPEEkkLSIFVEYMP 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTM 437
Cdd:cd06653   90 GGSVKDQLkAYGALTENVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTicmSGTGIKSV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELqnPERLSAVFRDFLNRcLE 516
Cdd:cd06653  170 TGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWAEYEAMAAIFKIATQPTkPQL--PDGVSDACRDFLRQ-IF 246
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06653  247 VEEKRRPTAEFLLR 260
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
289-530 7.29e-43

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 154.05  E-value: 7.29e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDE--LWVVMEYLA 361
Cdd:cd06652   10 LGQGAFGRVYLCYDADTGRELAVKQVQFDpESPETSKEVNalecEIQLLKNLLHERIVQYYGCLRDPQErtLSIFMEYMP 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQSKRSTM 437
Cdd:cd06652   90 GGSIKDQLKSyGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASKRlqtICLSGTGMKSV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELqnPERLSAVFRDFLNRCLe 516
Cdd:cd06652  170 TGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTnPQL--PAHVSDHCRDFLKRIF- 246
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd06652  247 VEAKLRPSADELLR 260
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
289-530 1.76e-42

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 152.42  E-value: 1.76e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQqPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD- 367
Cdd:cd14006    1 LGRGRFGVVKRCIEKATGREFAAKFIPKRD-KKKEAVLREISILNQLQHPRIIQLHEAYESPTELVLILELCSGGELLDr 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFGFCAQITPEQSKRSTMvGTPYWMA 445
Cdd:cd14006   80 LAERGSLSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLadRPSPQIKIIDFGLARKLNPGEELKEIF-GTPEFVA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 446 PEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRRG 523
Cdd:cd14006  159 PEIVNGEPVSLATDMWSIGVLTYVLLSGLSPFLGEDD-QETLANISACRVDFSEEyfSSVSQEAKDFIRKLLVKEPRKRP 237

                 ....*..
gi 578838380 524 SAKELLQ 530
Cdd:cd14006  238 TAQEALQ 244
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
281-530 2.48e-42

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 153.20  E-value: 2.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIK-------QMNLQQ-QPKKELIINEILVMRENKN-PNIVNYLDSYLVGD 351
Cdd:cd14181   10 QKYDPKEVIGRGVSSVVRRCVHRHTGQEFAVKiievtaeRLSPEQlEEVRSSTLKEIHILRQVSGhPSIITLIDSYESST 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd14181   90 FIFLVFDLMRRGELFDYLTEkVTLSEKETRSIMRSLLEAVSYLHANNIVHRDLKPENILLDDQLHIKLSDFGFSCHLEPG 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRStMVGTPYWMAPEVV------TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPE--R 502
Cdd:cd14181  170 EKLRE-LCGTPGYLAPEILkcsmdeTHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQMLMLRMI-MEGRYQFSSPEwdD 247
                        250       260
                 ....*....|....*....|....*...
gi 578838380 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14181  248 RSSTVKDLISRLLVVDPEIRLTAEQALQ 275
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
282-530 5.36e-42

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 152.73  E-value: 5.36e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN-----EILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd07841    1 RYEKGKKLGEGTYAVVYKARDKETGRIVAIKKIKLGERKEAKDGINftalrEIKLLQELKHPNIIGLLDVFGHKSNINLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGgSLTDVVTETCMD--EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd07841   81 FEFMET-DLEKVIKDKSIVltPADIKSYMLMTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARSFGSPNRKM 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVV-TRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTPELQN------------ 499
Cdd:cd07841  160 THQVVTRWYRAPELLfGARHYGVGVDMWSVGcIFA-ELLLRVPFLPGDSDIDQLGKIfEALGTPTEENwpgvtslpdyve 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 578838380 500 -----PERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07841  239 fkpfpPTPLKQIFPaasddalDLLQRLLTLNPNKRITARQALE 281
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
283-522 8.01e-42

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 151.50  E-value: 8.01e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEV-AIKQMNLQQ----QPKKEL------IINEILVMREN-KNPNIVNYLDSYLVG 350
Cdd:cd08528    2 YAVLELLGSGAFGCVYKVRKKSNGQTLlALKEINMTNpafgRTEQERdksvgdIISEVNIIKEQlRHPNIVRYYKTFLEN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTDVVT---ETCM--DEGQIAAVCRECLQALDFLH-SNQVIHRDIKSDNILLGMDGSVKLTDFGFC 424
Cdd:cd08528   82 DRLYIVMELIEGAPLGEHFSslkEKNEhfTEDRIWNIFVQMVLALRYLHkEKQIVHRDLKPNNIMLGEDDKVTITDFGLA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 425 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPERLS 504
Cdd:cd08528  162 KQKGPESSKMTSVVGTILYSCPEIVQNEPYGEKADIWALGCILYQMCTLQPPFYSTNMLTLATKI-VEAEYEPLPEGMYS 240
                        250
                 ....*....|....*...
gi 578838380 505 AVFRDFLNRCLEMDVDRR 522
Cdd:cd08528  241 DDITFVIRSCLTPDPEAR 258
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
286-530 1.35e-41

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 153.21  E-value: 1.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEK---IGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05573    3 FEVikvIGRGAFGEVWLVRDKDTGQVYAMKILRksdMLKREQIAHVRAERDILADADSPWIVRLHYAFQDEDHLYLVMEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLT------DVVTETcMDEGQIAavcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI------ 427
Cdd:cd05573   83 MPGGDLMnllikyDVFPEE-TARFYIA----ELVLALDSLHKLGFIHRDIKPDNILLDADGHIKLADFGLCTKMnksgdr 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 -------------------TPEQSKR----STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 484
Cdd:cd05573  158 esylndsvntlfqdnvlarRRPHKQRrvraYSAVGTPDYIAPEVLRGTGYGPECDWWSLGVILYEMLYGFPPFYSDSLVE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 485 AlYLIATNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd05573  238 T-YSKIMNWKESLVFPddPDVSPEAIDLIRRLLCDPEDRLGSAEEIKA 284
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
289-530 1.92e-41

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 150.10  E-value: 1.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05578    8 IGKGSFGKVCIVQKKDTKKMFAMKYMNKQKCIEKDsvrNVLNELEILQELEHPFLVNLWYSFQDEEDMYMVVDLLLGGDL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -----TDVVtetcMDEGQIAA-VCRECLqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVG 439
Cdd:cd05578   88 ryhlqQKVK----FSEETVKFyICEIVL-ALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNI-ATKLTDGTLATSTSG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-----ENPLRALYLIATNGTPELQNPErlsavFRDFLNRC 514
Cdd:cd05578  162 TKPYMAPEVFMRAGYSFAVDWWSLGVTAYEMLRGKRPYEIhsrtsIEEIRAKFETASVLYPAGWSEE-----AIDLINKL 236
                        250
                 ....*....|....*..
gi 578838380 515 LEMDVDRR-GSAKELLQ 530
Cdd:cd05578  237 LERDPQKRlGDLSDLKN 253
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
281-530 1.92e-41

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 151.04  E-value: 1.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN------LQQQPKKELIINeilvmRENKNPNIVNYLDSYLvgDE-- 352
Cdd:cd06621    1 DKIVELSSLGEGAGGSVTKCRLRNTKTIFALKTITtdpnpdVQKQILRELEIN-----KSCASPYIVKYYGAFL--DEqd 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 --LWVVMEYLAGGSLTDVVTETCMDEGQIA-----AVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 425
Cdd:cd06621   74 ssIGIAMEYCEGGSLDSIYKKVKKKGGRIGekvlgKIAESVLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITpeQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN-----PLRALYLIATNGTPELQNP 500
Cdd:cd06621  154 ELV--NSLAGTFTGTSYYMAPERIQGGPYSITSDVWSLGLTLLEVAQNRFPFPPEGepplgPIELLSYIVNMPNPELKDE 231
                        250       260       270
                 ....*....|....*....|....*....|....
gi 578838380 501 E----RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06621  232 PengiKWSESFKDFIEKCLEKDGTRRPGPWQMLA 265
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
282-530 2.19e-41

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 149.93  E-value: 2.19e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14098    1 KYQIIDRLGSGTFAEVKKAVEVETGKMRAIKQIVkrkvAGNDKNLQLFQREINILKSLEHPGIVRLIDWYEDDQHIYLVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFcAQITPEQSKR 434
Cdd:cd14098   81 EYVEGGDLMDFIMAWgAIPEQHARELTKQILEAMAYTHSMGITHRDLKPENILITQDDPviVKISDFGL-AKVIHTGTFL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRK------AYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYLIATNGT----PELQNpeRLS 504
Cdd:cd14098  160 VTFCGTMAYLAPEILMSKeqnlqgGYSNLVDMWSVGCLVYVMLTGALPF-DGSSQLPVEKRIRKGRytqpPLVDF--NIS 236
                        250       260
                 ....*....|....*....|....*.
gi 578838380 505 AVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14098  237 EEAIDFILRLLDVDPEKRMTAAQALD 262
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
281-530 2.60e-41

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 150.24  E-value: 2.60e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQP--------KKELIINEILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd14084    6 KKYIMSRTLGSGACGEVKLAYDKSTCKKVAIKIINKRKFTigsrreinKPRNIETEIEILKKLSHPCIIKIEDFFDAEDD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFcAQIT 428
Cdd:cd14084   86 YYIVLELMEGGELFDrVVSNKRLKEAICKLYFYQMLLAVKYLHSNGIIHRDLKPENVLLSSQEEeclIKITDFGL-SKIL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQSKRSTMVGTPYWMAPEVVT---RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERL 503
Cdd:cd14084  165 GETSLMKTLCGTPTYLAPEVLRsfgTEGYTRAVDCWSLGVILFICLSGYPPFSEEYTQMSLKEQILSGkyTFIPKAWKNV 244
                        250       260
                 ....*....|....*....|....*..
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14084  245 SEEAKDLVKKMLVVDPSRRPSIEEALE 271
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
282-530 2.81e-41

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 150.20  E-value: 2.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--------KELIINEILVMRE-NKNPNIVNYLDSYLVGDE 352
Cdd:cd14093    4 KYEPKEILGRGVSSTVRRCIEKETGQEFAVKIIDITGEKSseneaeelREATRREIEILRQvSGHPNIIELHDVFESPTF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd14093   84 IFLVFELCRKGELFDYLTEVVtLSEKKTRRIMRQLFEAVEFLHSLNIVHRDLKPENILLDDNLNVKISDFGFATRLDEGE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 sKRSTMVGTPYWMAPEVVTRK------AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPE--RL 503
Cdd:cd14093  164 -KLRELCGTPGYLAPEVLKCSmydnapGYGKEVDMWACGVIMYTLLAGCPPFWHRKQMVMLRNI-MEGKYEFGSPEwdDI 241
                        250       260
                 ....*....|....*....|....*..
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14093  242 SDTAKDLISKLLVVDPKKRLTAEEALE 268
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
282-529 2.90e-41

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 150.56  E-value: 2.90e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLqqqPKKE-----LIINEILVMRENK-NPNIVNYLDSYLVGDELWV 355
Cdd:cd07832    1 RYKILGRIGEGAHGIVFKAKDRETGETVALKKVAL---RKLEggipnQALREIKALQACQgHPYVVKLRDVFPHGTGFVL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLaGGSLTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSK 433
Cdd:cd07832   78 VFEYM-LSSLSEVLrdEERPLTEAQVKRYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGL-ARLFSEEDP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 R--STMVGTPYWMAPEVV--TRKaYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRAL-YLIATNGTPELQN-------- 499
Cdd:cd07832  156 RlySHQVATRWYRAPELLygSRK-YDEGVDLWAVGcIFA-ELLNGSPLFPGENDIEQLaIVLRTLGTPNEKTwpeltslp 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 500 -----------PERLSAVFR-------DFLNRCLEMDVDRRGSAKELL 529
Cdd:cd07832  234 dynkitfpeskGIRLEEIFPdcspeaiDLLKGLLVYNPKKRLSAEEAL 281
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
288-530 2.96e-41

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 151.29  E-value: 2.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd08216    5 EIGKCFKGggVVHLAKHKPTNTLVAVKKINLESDSKEDLkfLQQEILTSRQLQHPNILPYVTSFVVDNDLYVVTPLMAYG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 440
Cdd:cd08216   85 SCRDLLKTHFPEglpELAIAFILRDVLNALEYIHSKGYIHRSVKASHILISGDGKVVLSGLRYAYSMVKHGKRQRVVHDF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 P-------YWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYLIATNGTP--------------EL 497
Cdd:cd08216  165 PksseknlPWLSPEVLQQnlLGYNEKSDIYSVGITACELANGVVPF-SDMPATQMLLEKVRGTTpqlldcstypleedSM 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 498 QNPE-------------------RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd08216  244 SQSEdsstehpnnrdtrdipyqrTFSEAFHQFVELCLQRDPELRPSASQLLA 295
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
289-532 3.95e-41

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 149.79  E-value: 3.95e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGD----ELWVVMEYlAGG 363
Cdd:cd13985    8 LGEGGFSYVYLAHDVNTGRRYALKRMYFNDEEQLRVAIKEIEIMKRlCGHPNIVQYYDSAILSSegrkEVLLLMEY-CPG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS--- 435
Cdd:cd13985   87 SLVDILEKSPpspLSEEEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNTGRFKLCDFGSATTEHYPLERAEevn 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 ------TMVGTPYWMAPEVV---TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALyliatNGTPELQNPERLSAV 506
Cdd:cd13985  167 iieeeiQKNTTPMYRAPEMIdlySKKPIGEKADIWALGCLLYKLCFFKLPFDESSKLAIV-----AGKYSIPEQPRYSPE 241
                        250       260
                 ....*....|....*....|....*.
gi 578838380 507 FRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd13985  242 LHDLIRHMLTPDPAERPDIFQVINII 267
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
280-530 6.29e-41

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 148.67  E-value: 6.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14083    2 RDKYEFKEVLGTGAFSEVVLAEDKATGKLVAIKCIDKKAlKGKEDSLENEIAVLRKIKHPNIVQLLDIYESKSHLYLVME 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL---LGMDGSVKLTDFGFCAqiTPEQSKR 434
Cdd:cd14083   82 LVTGGELFDrIVEKGSYTEKDASHLIRQVLEAVDYLHSLGIVHRDLKPENLLyysPDEDSKIMISDFGLSK--MEDSGVM 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP-------LRALYliatngtpELQNP--ERLSA 505
Cdd:cd14083  160 STACGTPGYVAPEVLAQKPYGKAVDCWSIGVISYILLCGYPPFYDENDsklfaqiLKAEY--------EFDSPywDDISD 231
                        250       260
                 ....*....|....*....|....*
gi 578838380 506 VFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14083  232 SAKDFIRHLMEKDPNKRYTCEQALE 256
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
282-529 8.41e-41

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 148.34  E-value: 8.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE--LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd08220    1 KYEKIRVVGRGAYGTVYLCRRKDDNKLVIIKQIPVEQMTKEErqAALNEVKVLSMLHHPNIIEYYESFLEDKALMIVMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFcAQITPEQSKRS 435
Cdd:cd08220   81 APGGTLFEYIQQRKgslLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNKKRTvVKIGDFGI-SKILSSKSKAY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGT--PElqnPERLSAVFRDFLNR 513
Cdd:cd08220  160 TVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAAN-LPALVLKIMRGTfaPI---SDRYSEELRHLILS 235
                        250
                 ....*....|....*.
gi 578838380 514 CLEMDVDRRGSAKELL 529
Cdd:cd08220  236 MLHLDPNKRPTLSEIM 251
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
287-532 1.63e-40

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 147.69  E-value: 1.63e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAL---DIATGQEVAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd00192    1 KKLGEGAFGEVYKGKlkgGDGKTVDVAVKTLKEDaSESERKDFLKEARVMKKLGHPNVVRLLGVCTEEEPLYLVMEYMEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSL----------TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd00192   81 GDLldflrksrpvFPSPEPSTLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSRDIYDDDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMvGTP---YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIaTNGTpELQNPERLSAVFR 508
Cdd:cd00192  161 YRKKT-GGKlpiRWMAPESLKDGIFTSKSDVWSFGVLLWEIFTlGATPYPGLSNEEVLEYL-RKGY-RLPKPENCPDELY 237
                        250       260
                 ....*....|....*....|....
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd00192  238 ELMLSCWQLDPEDRPTFSELVERL 261
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
287-532 5.40e-40

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 146.10  E-value: 5.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  287 EKIGQGASGTVY----TALDIATGQEVAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:pfam07714   5 EKLGEGAFGEVYkgtlKGEGENTKIKVAVKTLKEGaDEEEREDFLEEASIMKKLDHPNIVKLLGVCTQGEPLYIVTEYMP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  362 GGSLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:pfam07714  85 GGDLLDFLRKhkRKLTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYYRKRGGG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  440 -TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNG---TPELqNPERLsavfRDFLNR 513
Cdd:pfam07714 165 kLPIkWMAPESLKDGKFTSKSDVWSFGVLLWEIFTlGEQPYPGMSNEEVLEFLEDGYrlpQPEN-CPDEL----YDLMKQ 239
                         250
                  ....*....|....*....
gi 578838380  514 CLEMDVDRRGSAKELLQVL 532
Cdd:pfam07714 240 CWAYDPEDRPTFSELVEDL 258
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
283-530 7.96e-40

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 146.00  E-value: 7.96e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDE--LWV 355
Cdd:cd06651    9 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDpESPETSKEVSalecEIQLLKNLQHERIVQYYGCLRDRAEktLTI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ---ITPEQ 431
Cdd:cd06651   89 FMEYMPGGSVKDQLKAyGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRlqtICMSG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELqnPERLSAVFRDF 510
Cdd:cd06651  169 TGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTnPQL--PSHISEHARDF 246
                        250       260
                 ....*....|....*....|
gi 578838380 511 LnRCLEMDVDRRGSAKELLQ 530
Cdd:cd06651  247 L-GCIFVEARHRPSAEELLR 265
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
283-530 1.05e-39

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 146.14  E-value: 1.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd07830    1 YKVIKQLGDGTFGSVYLARNKETGELVAIKKMKKKFYSWEECMnLREVKSLRKlNEHPNIVKLKEVFRENDELYFVFEYM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGgSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfCAQITPEQSKRSTM 437
Cdd:cd07830   81 EG-NLYQLMKDrkgKPFSESVIRSIIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFG-LAREIRSRPPYTDY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQN-PE--RL--------- 503
Cdd:cd07830  159 VSTRWYRAPEILLRsTSYSSPVDIWALGCIMAELYTLRPLFPGSSEIDQLYKIcSVLGTPTKQDwPEgyKLasklgfrfp 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 504 --------------SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07830  239 qfaptslhqlipnaSPEAIDLIKDMLRWDPKKRPTASQALQ 279
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
288-531 5.55e-39

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 143.57  E-value: 5.55e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd08224    7 KIGKGQFSVVYRARCLLDGRLVALKKVQifeMMDAKARQDCLKEIDLLQQLNHPNIIKYLASFIENNELNIVLELADAGD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTE-----TCMDEGQI----AAVCReclqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
Cdd:cd08224   87 LSRLIKHfkkqkRLIPERTIwkyfVQLCS----ALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLGRFFSSKTTAAH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN-PLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd08224  163 SLVGTPYYMSPERIREQGYDFKSDIWSLGCLLYEMAALQSPFYGEKmNLYSLCKKIEKCEYPPLPADLYSQELRDLVAAC 242
                        250
                 ....*....|....*..
gi 578838380 515 LEMDVDRRGSAKELLQV 531
Cdd:cd08224  243 IQPDPEKRPDISYVLDV 259
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
287-522 2.09e-38

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 141.66  E-value: 2.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQE-VAIKQMNlqqqpKKEL-------IINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14121    1 EKLGSGTYATVYKAYRKSGAREvVAVKCVS-----KSSLnkastenLLTEIELLKKLKHPHIVELKDFQWDEEHIYLIME 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVV-TETCMDEGqiaaVCRECLQ----ALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd14121   76 YCSGGDLSRFIrSRRTLPES----TVRRFLQqlasALQFLREHNISHMDLKPQNLLLssRYNPVLKLADFGFAQHLKPND 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY----LNENPLRalylIATNGTPELQNPERLSAVF 507
Cdd:cd14121  152 EAHS-LRGSPLYMAPEMILKKKYDARVDLWSVGVILYECLFGRAPFasrsFEELEEK----IRSSKPIEIPTRPELSADC 226
                        250
                 ....*....|....*
gi 578838380 508 RDFLNRCLEMDVDRR 522
Cdd:cd14121  227 RDLLLRLLQRDPDRR 241
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
281-530 4.66e-38

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 141.79  E-value: 4.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14086    1 DEYDLKEELGKGAFSVVRRCVQKSTGQEFAAKIINTKKLSARDHqkLEREARICRLLKHPNIVRLHDSISEEGFHYLVFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM---DGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd14086   81 LVTGGELfEDIVAREFYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASkskGAAVKLADFGLAIEVQGDQQAW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGTPELQNPE--RLSAVFRDFLN 512
Cdd:cd14086  161 FGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHR-LYAQIKAGAYDYPSPEwdTVTPEAKDLIN 239
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14086  240 QMLTVNPAKRITAAEALK 257
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
281-530 5.85e-38

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 140.81  E-value: 5.85e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDiATGQEVAIKQMNLQ---QQPKKELIiNEI-LVMRENKNPNIVNYLDsYLVGDE---L 353
Cdd:cd14131    1 KPYEILKQLGKGGSSKVYKVLN-PKKKIYALKRVDLEgadEQTLQSYK-NEIeLLKKLKGSDRIIQLYD-YEVTDEddyL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYlagGSlTDVVT------ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSVKLTDFGFCAQI 427
Cdd:cd14131   78 YMVMEC---GE-IDLATilkkkrPKPIDPNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANFLL-VKGRLKLIDFGIAKAI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQS--KRSTMVGTPYWMAPEVVTRKAY----------GPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT 494
Cdd:cd14131  153 QNDTTsiVRDSQVGTLNYMSPEAIKDTSAsgegkpkskiGRPSDVWSLGCILYQMVYGKTPFQHiTNPIAKLQAIIDPNH 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578838380 495 ----PELQNPERLsavfrDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14131  233 eiefPDIPNPDLI-----DVMKRCLQRDPKKRPSIPELLN 267
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
283-530 6.67e-38

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 141.23  E-value: 6.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQM-NLQQQPKKELiinEILvMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14091    2 YEIKEEIGKGSYSVCKRCIHKATGKEYAVKIIdKSKRDPSEEI---EIL-LRYGQHPNIITLRDVYDDGNSVYLVTELLR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG----SVKLTDFGFCAQITPEQSkrst 436
Cdd:cd14091   78 GGELLDrILRQKFFSEREASAVMKTLTKTVEYLHSQGVVHRDLKPSNILYADESgdpeSLRICDFGFAKQLRAENG---- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTP-Y---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN---ENPLRALYLIaTNGTPELQNP--ERLSAVF 507
Cdd:cd14091  154 LLMTPcYtanFVAPEVLKKQGYDAACDIWSLGVLLYTMLAGYTPFASgpnDTPEVILARI-GSGKIDLSGGnwDHVSDSA 232
                        250       260
                 ....*....|....*....|...
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14091  233 KDLVRKMLHVDPSQRPTAAQVLQ 255
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
283-530 6.84e-38

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 140.51  E-value: 6.84e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKkelIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14010    2 YVLYDEIGRGKHSVVYKGRRKGTIEFVAIKCVDKSKRPE---VLNEVRLTHELKHPNVLKFYEWYETSNHLWLVVEYCTG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG---------------FCAQ 426
Cdd:cd14010   79 GDLETLLRQdGNLPESSVRKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGlarregeilkelfgqFSDE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 427 ITPEQ-SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP--ERL 503
Cdd:cd14010  159 GNVNKvSKKQAKRGTPYYMAPELFQGGVHSFASDLWALGCVLYEMFTGKPPFVAESFTELVEKILNEDPPPPPPKvsSKP 238
                        250       260
                 ....*....|....*....|....*..
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14010  239 SPDFKSLLKGLLEKDPAKRLSWDELVK 265
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
282-530 8.22e-38

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 140.23  E-value: 8.22e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14663    1 RYELGRTLGEGTFAKVKFARNTKTGESVAIKIIDKEQVAREgmvEQIKREIAIMKLLRHPNIVELHEVMATKTKIFFVME 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAqiTPEQSKRSTM 437
Cdd:cd14663   81 LVTGGELFSkIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLSA--LSEQFRQDGL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 V----GTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRDFLN 512
Cdd:cd14663  159 LhttcGTPNYVAPEVLARRGYdGAKADIWSCGVILFVLLAGYLPFDDEN-LMALYRKIMKGEFEY--PRWFSPGAKSLIK 235
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14663  236 RILDPNPSTRITVEQIMA 253
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
283-530 9.28e-38

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 140.78  E-value: 9.28e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQqpKKE----LIINEILVMRENKNPNIVNYLD------SYLVGDE 352
Cdd:cd07840    1 YEKIAQIGEGTYGQVYKARNKKTGELVALKKIRMEN--EKEgfpiTAIREIKLLQKLDHPNVVRLKEivtskgSAKYKGS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEY----LAGgsLTDVvTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd07840   79 IYMVFEYmdhdLTG--LLDN-PEVKFTESQIKCYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPYT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQSKRST-MVGTPYWMAPEVV---TRkaYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-TNGTP-------- 495
Cdd:cd07840  156 KENNADYTnRVITLWYRPPELLlgaTR--YGPEVDMWSVGCILAELFTGKPIFQGKTELEQLEKIFeLCGSPteenwpgv 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578838380 496 -------ELQNPERLSAVFRDFLNRC------------LEMDVDRRGSAKELLQ 530
Cdd:cd07840  234 sdlpwfeNLKPKKPYKRRLREVFKNVidpsaldlldklLTLDPKKRISADQALQ 287
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
282-530 1.37e-37

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 139.58  E-value: 1.37e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14072    1 NYRLLKTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLqkLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPeQSKRSTMV 438
Cdd:cd14072   81 ASGGEVFDyLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTP-GNKLDTFC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY-------LNENPLRALYLIatngtpelqnPERLSAVFRDF 510
Cdd:cd14072  160 GSPPYAAPELFQGKKYdGPEVDVWSLGVILYTLVSGSLPFdgqnlkeLRERVLRGKYRI----------PFYMSTDCENL 229
                        250       260
                 ....*....|....*....|
gi 578838380 511 LNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14072  230 LKKFLVLNPSKRGTLEQIMK 249
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
289-530 3.21e-37

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 138.62  E-value: 3.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14069    9 LGEGAFGEVFLAVNRNTEEAVAVKFVDMKRAPGdcPENIKKEVCIQKMLSHKNVVRFYGHRREGEFQYLFLEYASGGELF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR--STMVGTPYW 443
Cdd:cd14069   89 DKIEPDVgMPEDVAQFYFQQLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGLATVFRYKGKERllNKMCGTLPY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP-ERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd14069  169 VAPELLAKKKYrAEPVDVWSCGIVLFAMLAGELPWDQPSDSCQEYSDWKENKKTYLTPwKKIDTAALSLLRKILTENPNK 248

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd14069  249 RITIEDIKK 257
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
280-545 3.53e-37

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 139.36  E-value: 3.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14166    2 RETFIFMEVLGSGAFSEVYLVKQRSTGKLYALKCIKKSPLSRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL-LGMDGSVKL--TDFGFCAQitPEQSKRS 435
Cdd:cd14166   82 VSGGELFDRILERgVYTEKDASRVINQVLSAVKYLHENGIVHRDLKPENLLyLTPDENSKImiTDFGLSKM--EQNGIMS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGTPELQNP--ERLSAVFRDFLNR 513
Cdd:cd14166  160 TACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESR-LFEKIKEGYYEFESPfwDDISESAKDFIRH 238
                        250       260       270
                 ....*....|....*....|....*....|..
gi 578838380 514 CLEMDVDRRGSAKELLQVLLAGGNSLHNYAII 545
Cdd:cd14166  239 LLEKNPSKRYTCEKALSHPWIIGNTALHRDIY 270
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
280-529 5.01e-37

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 137.90  E-value: 5.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlqqqpKKEL------IINEILVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd14078    2 LKYYELHETIGSGGFAKVKLATHILTGEKVAIKIMD-----KKALgddlprVKTEIEALKNLSHQHICRLYHVIETDNKI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQitPEQS 432
Cdd:cd14078   77 FMVLEYCPGGELFDyIVAKDRLSEDEARVFFRQIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGLCAK--PKGG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRS---TMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGtpELQNPERLSAVFR 508
Cdd:cd14078  155 MDHhleTCCGSPAYAAPELIQGKPYiGSEADVWSMGVLLYALLCGFLPFDDDN-VMALYRKIQSG--KYEEPEWLSPSSK 231
                        250       260
                 ....*....|....*....|.
gi 578838380 509 DFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14078  232 LLLDQMLQVDPKKRITVKELL 252
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
280-530 7.58e-37

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 137.85  E-value: 7.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqqPKKEL------IINEILVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd14167    2 RDIYDFREVLGTGAFSEVVLAEEKRTQKLVAIKCI-----AKKALegketsIENEIAVLHKIKHPNIVALDDIYESGGHL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTDVVTETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL---LGMDGSVKLTDFGFcAQITP 429
Cdd:cd14167   77 YLIMQLVSGGELFDRIVEKGFyTERDASKLIFQILDAVKYLHDMGIVHRDLKPENLLyysLDEDSKIMISDFGL-SKIEG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGTPELQNP--ERLSAVF 507
Cdd:cd14167  156 SGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAK-LFEQILKAEYEFDSPywDDISDSA 234
                        250       260
                 ....*....|....*....|...
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14167  235 KDFIQHLMEKDPEKRFTCEQALQ 257
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
288-529 1.17e-36

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 137.96  E-value: 1.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLV-GDELWVVMEYLAGGSL 365
Cdd:cd06620   12 DLGAGNGGSVSKVLHIPTGTIMAKKVIHIDAKSSvRKQILRELQILHECHSPYIVSFYGAFLNeNNNIIICMEYMDCGSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -------TDVVTETCmdeGQIA-AVcrecLQALDFLHS-NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRST 436
Cdd:cd06620   92 dkilkkkGPFPEEVL---GKIAvAV----LEGLTYLYNvHRIIHRDIKPSNILVNSKGQIKLCDFGVSGELI--NSIADT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL-----------IATNGTPELQNPERLSA 505
Cdd:cd06620  163 FVGTSTYMSPERIQGGKYSVKSDVWSLGLSIIELALGEFPFAGSNDDDDGYNgpmgildllqrIVNEPPPRLPKDRIFPK 242
                        250       260
                 ....*....|....*....|....
gi 578838380 506 VFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd06620  243 DLRDFVDRCLLKDPRERPSPQLLL 266
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
282-530 1.49e-36

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 137.55  E-value: 1.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd07846    2 KYENLGLVGEGSYGMVMKCRHKETGQIVAIKKFLESEDDKmvKKIAMREIKMLKQLRHENLVNLIEVFRRKKRWYLVFEF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDV-VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd07846   82 VDHTVLDDLeKYPNGLDESRVRKYLFQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPE-VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI---------------------ATNGTPE 496
Cdd:cd07846  162 ATRWYRAPElLVGDTKYGKAVDVWAVGCLVTEMLTGEPLFPGDSDIDQLYHIikclgnliprhqelfqknplfAGVRLPE 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 497 LQNPE-------RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07846  242 VKEVEplerrypKLSGVVIDLAKKCLHIDPDKRPSCSELLH 282
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
282-530 1.85e-36

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 136.40  E-value: 1.85e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKELIINE-ILVMRENK------NPNIVNYLDSYLVGDELW 354
Cdd:cd08222    1 RYRVVRKLGSGNFGTVYLVSDLKATADEELKV--LKEISVGELQPDEtVDANREAKllskldHPAIVKFHDSFVEKESFC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTE-----TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSVKLTDFGFCAQITP 429
Cdd:cd08222   79 IVTEYCEGGDLDDKISEykksgTTIDENQILDWFIQLLLAVQYMHERRILHRDLKAKNIFL-KNNVIKVGDFGISRILMG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELqnPERLSAVFRD 509
Cdd:cd08222  158 TSDLATTFTGTPYYMSPEVLKHEGYNSKSDIWSLGCILYEMCCLKHAFDGQNLLSVMYKIVEGETPSL--PDKYSKELNA 235
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd08222  236 IYSRMLNKDPALRPSAAEILK 256
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
287-526 2.10e-36

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 138.41  E-value: 2.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:PTZ00263  24 ETLGTGSFGRVRIAKHKGTGEYYAIKCLKKREilkMKQVQHVAQEKSILMELSHPFIVNMMCSFQDENRVYFLLEFVVGG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTETCMDEGQIAAV-CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeqSKRSTMVGTPY 442
Cdd:PTZ00263 104 ELFTHLRKAGRFPNDVAKFyHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKKVP---DRTFTLCGTPE 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:PTZ00263 181 YLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGYPPFFDDTPFRIYEKILAG---RLKFPNWFDGRARDLVKGLLQTDHTKR 257

                 ....*
gi 578838380 523 -GSAK 526
Cdd:PTZ00263 258 lGTLK 262
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
281-529 2.33e-36

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 136.31  E-value: 2.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE-LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14184    1 EKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKAKCCGKEhLIENEVSILRRVKHPNIIMLIEEMDTPAELYLVMEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM--DG--SVKLTDFGFCAQItpeQSKR 434
Cdd:cd14184   81 VKGGDLFDAITSsTKYTERDASAMVYNLASALKYLHGLCIVHRDIKPENLLVCEypDGtkSLKLGDFGLATVV---EGPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA-LYLIATNGTPELQNP--ERLSAVFRDFL 511
Cdd:cd14184  158 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEdLFDQILLGKLEFPSPywDNITDSAKELI 237
                        250
                 ....*....|....*...
gi 578838380 512 NRCLEMDVDRRGSAKELL 529
Cdd:cd14184  238 SHMLQVNVEARYTAEQIL 255
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
283-526 3.34e-36

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 136.80  E-value: 3.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05612    3 FERIKTIGTGTFGRVHLVRDRISEHYYALKVMAIPEvirLKQEQHVHNEKRVLKEVSHPFIIRLFWTEHDQRFLYMLMEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpeQSKRSTMV 438
Cdd:cd05612   83 VPGGELfSYLRNSGRFSNSTGLFYASEIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKL---RDRTWTLC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLrALYLIATNGtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05612  160 GTPEYLAPEVIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPF-GIYEKILAG--KLEFPRHLDLYAKDLIKKLLVVD 236

                 ....*....
gi 578838380 519 VDRR-GSAK 526
Cdd:cd05612  237 RTRRlGNMK 245
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
289-530 4.59e-36

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 135.05  E-value: 4.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14103    1 LGRGKFGTVYRCVEKATGKELAAKFIKCRKAKDREDVRNEIEIMNQLRHPRLLQLYDAFETPREMVLVMEYVAGGELFER 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VTETCMDEGQIAAV--CRECLQALDFLHSNQVIHRDIKSDNIL-LGMDGS-VKLTDFGFCAQITPEQSKRsTMVGTPYWM 444
Cdd:cd14103   81 VVDDDFELTERDCIlfMRQICEGVQYMHKQGILHLDLKPENILcVSRTGNqIKIIDFGLARKYDPDKKLK-VLFGTPEFV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd14103  160 APEVVNYEPISYATDMWSVGVICYVLLSGLSPFMGDNDAETLANV-TRAKWDFDDEafDDISDEAKDFISKLLVKDPRKR 238

                 ....*...
gi 578838380 523 GSAKELLQ 530
Cdd:cd14103  239 MSAAQCLQ 246
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
281-529 4.87e-36

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 135.81  E-value: 4.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---------QQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVG 350
Cdd:cd14182    3 EKYEPKEILGRGVSSVVRRCIHKPTRQEYAVKIIDItgggsfspeEVQELREATLKEIDILRKvSGHPNIIQLKDTYETN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd14182   83 TFFFLVFDLMKKGELFDYLTEkVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQsKRSTMVGTPYWMAPEVV------TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPE-- 501
Cdd:cd14182  163 GE-KLREVCGTPGYLAPEIIecsmddNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMI-MSGNYQFGSPEwd 240
                        250       260
                 ....*....|....*....|....*...
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14182  241 DRSDTVKDLISRFLVVQPQKRYTAEEAL 268
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
287-530 6.62e-36

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 135.63  E-value: 6.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQM--NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEylaggs 364
Cdd:cd06617    7 EELGRGAYGVVDKMRHVPTGTIMAVKRIraTVNSQEQKRLLMDLDISMRSVDCPYTVTFYGALFREGDVWICME------ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 ltdvVTETCMD--------------EGQIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd06617   81 ----VMDTSLDkfykkvydkgltipEDILGKIAVSIVKALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGISGYLVD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYwMAPEVV----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNpERLS 504
Cdd:cd06617  157 SVAKTIDAGCKPY-MAPERInpelNQKGYDVKSDVWSLGITMIELATGRFPYDSwKTPFQQLKQVVEEPSPQLPA-EKFS 234
                        250       260
                 ....*....|....*....|....*.
gi 578838380 505 AVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06617  235 PEFQDFVNKCLKKNYKERPNYPELLQ 260
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
283-529 7.52e-36

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 135.64  E-value: 7.52e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDI-ATGQEVAIK--------QMNLQQQPKKElIINEILVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd14096    3 YRLINKIGEGAFSNVYKAVPLrNTGKPVAIKvvrkadlsSDNLKGSSRAN-ILKEVQIMKRLSHPNIVKLLDFQESDEYY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---------------------- 410
Cdd:cd14096   82 YIVLELADGGEIFHqIVRLTYFSEDLSRHVITQVASAVKYLHEIGVVHRDIKPENLLFepipfipsivklrkadddetkv 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 411 -----------GMDGSVKLTDFGFCAQITPEQSKrsTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN 479
Cdd:cd14096  162 degefipgvggGGIGIVKLADFGLSKQVWDSNTK--TPCGTVGYTAPEVVKDERYSKKVDMWALGCVLYTLLCGFPPFYD 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 480 ENpLRALYLIATNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14096  240 ES-IETLTEKISRGDYTFLSPwwDEISKSAKDLISHLLTVDPAKRYDIDEFL 290
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
282-481 7.63e-36

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 134.70  E-value: 7.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQP--KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd08225    1 RYEIIKKIGEGSFGKIYLAKAKSDSEHCVIKEIDLTKMPvkEKEASKKEVILLAKMKHPNIVTFFASFQENGRLFIVMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCAQITPEQSKRS 435
Cdd:cd08225   81 CDGGDLMKRINRqrgVLFSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNGMVaKLGDFGIARQLNDSMELAY 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd08225  161 TCVGTPYYLSPEICQNRPYNNKTDIWSLGCVLYELCTLKHPFEGNN 206
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
283-522 9.51e-36

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 135.22  E-value: 9.51e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14209    3 FDRIKTLGTGSFGRVMLVRHKETGNYYAMKILDKQKVVKLkqvEHTLNEKRILQAINFPFLVKLEYSFKDNSNLYMVMEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpeQSKRSTMV 438
Cdd:cd14209   83 VPGGEMFSHLRRIGrFSEPHARFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKRV---KGRTWTLC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd14209  160 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLLQVD 236

                 ....
gi 578838380 519 VDRR 522
Cdd:cd14209  237 LTKR 240
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
289-522 1.05e-35

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 136.19  E-value: 1.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII---------NEILVMR-ENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05570    3 LGKGSFGKVMLAERKKTDELYAIKVL------KKEVIIedddvectmTEKRVLAlANRHPFLTGLHACFQTEDRLYFVME 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05570   77 YVNGGDLMfHIQRARRFTEERARFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKEGIWGGNTTSTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY------------LNENPlraLYliatngtpelqnPERLSA 505
Cdd:cd05570  157 CGTPDYIAPEILREQDYGFSVDWWALGVLLYEMLAGQSPFegddedelfeaiLNDEV---LY------------PRWLSR 221
                        250
                 ....*....|....*..
gi 578838380 506 VFRDFLNRCLEMDVDRR 522
Cdd:cd05570  222 EAVSILKGLLTKDPARR 238
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
289-530 1.66e-35

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 133.92  E-value: 1.66e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd14185    8 IGDGNFAVVKECRHWNENQEYAMKIIDKSKlKGKEDMIESEILIIKSLSHPNIVKLFEVYETEKEIYLILEYVRGGDLFD 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGS--VKLTDFGFCAQITpeqSKRSTMVGTPY 442
Cdd:cd14185   88 AIIESVkFTEHDAALMIIDLCEALVYIHSKHIVHRDLKPENLLVqhNPDKSttLKLADFGLAKYVT---GPIFTVCGTPT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNP--ERLSAVFRDFLNRCLEMDV 519
Cdd:cd14185  165 YVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSpERDQEELFQIIQLGHYEFLPPywDNISEAAKDLISRLLVVDP 244
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd14185  245 EKRYTAKQVLQ 255
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
286-522 2.13e-35

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 135.43  E-value: 2.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FE---KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN-----EILVmrENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd05599    3 FEplkVIGRGAFGEVRLVRKKDTGHVYAMKKLRKSEMLEKEQVAHvraerDILA--EADNPWVVKLYYSFQDEENLYLIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLT------DVVTEtcmDEGQ--IAavcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd05599   81 EFLPGGDMMtllmkkDTLTE---EETRfyIA----ETVLAIESIHKLGYIHRDIKPDNLLLDARGHIKLSDFGLCTGLKK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTmVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAlYLIATNGTPELQNPE--RLSAVF 507
Cdd:cd05599  154 SHLAYST-VGTPDYIAPEVFLQKGYGKECDWWSLGVIMYEMLIGYPPFCSDDPQET-CRKIMNWRETLVFPPevPISPEA 231
                        250
                 ....*....|....*
gi 578838380 508 RDFLNRCLeMDVDRR 522
Cdd:cd05599  232 KDLIERLL-CDAEHR 245
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
283-530 3.55e-35

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 133.55  E-value: 3.55e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ--QQPKKELIINEILVMRENKN---PNIVNYLDSYLVGD-----E 352
Cdd:cd07838    1 YEEVAEIGEGAYGTVYKARDLQDGRFVALKKVRVPlsEEGIPLSTIREIALLKQLESfehPNVVRLLDVCHGPRtdrelK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEY----LAGgsLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQIT 428
Cdd:cd07838   81 LTLVFEHvdqdLAT--YLDKCPKPGLPPETIKDLMRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGL-ARIY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAV 506
Cdd:cd07838  158 SFEMALTSVVVTLWYRAPEVLLQSSYATPVDMWSVGcIFA-ELFNRRPLFRGSSEADQLGKIfDVIGLPSEEEWPRNSAL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 507 FR-----------------------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07838  237 PRssfpsytprpfksfvpeideeglDLLKKMLTFNPHKRISAFEALQ 283
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
289-526 4.98e-35

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 132.73  E-value: 4.98e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQM------NLQQQpkkELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd05572    1 LGVGGFGRVELVQLKSKGRTFALKCVkkrhivQTRQQ---EHIFSEKEILEECNSPFIVKLYRTFKDKKYLYMLMEYCLG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTET-CMDEGQ----IAAVcrecLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQsKRSTM 437
Cdd:cd05572   78 GELWTILRDRgLFDEYTarfyTACV----VLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGR-KTWTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY--LNENPLRaLYLIATNGTPELQNPERLSAVFRDFLNR-C 514
Cdd:cd05572  153 CGTPEYVAPEIILNKGYDFSVDYWSLGILLYELLTGRPPFggDDEDPMK-IYNIILKGIDKIEFPKYIDKNAKNLIKQlL 231
                        250
                 ....*....|..
gi 578838380 515 LEMDVDRRGSAK 526
Cdd:cd05572  232 RRNPEERLGYLK 243
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
336-522 7.97e-35

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 133.68  E-value: 7.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 336 KNPNIVNYLDSYLVGDELWVVMEYLAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 414
Cdd:cd05584   58 KHPFIVDLHYAFQTGGKLYLILEYLSGGELfMHLEREGIFMEDTACFYLAEITLALGHLHSLGIIYRDLKPENILLDAQG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 415 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgt 494
Cdd:cd05584  138 HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGAPPFTAENRKKTIDKILKG-- 215
                        170       180
                 ....*....|....*....|....*...
gi 578838380 495 pELQNPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd05584  216 -KLNLPPYLTNEARDLLKKLLKRNVSSR 242
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
282-530 1.14e-34

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 131.35  E-value: 1.14e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIIN--------------EILVM---RENKNPNIVNYL 344
Cdd:cd14004    1 DYTILKEMGEGAYGQVNLAIYKSKGKEVVIKFI------FKERILVdtwvrdrklgtvplEIHILdtlNKRSHPNIVKLL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 345 DSYLVGDELWVVMEYLAGG-SLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Cdd:cd14004   75 DFFEDDEFYYLVMEKHGSGmDLFDFIeRKPNMDEKEAKYIFRQVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDFG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 423 FCAQItpEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNenplralylIATNGTPELQNPE 501
Cdd:cd14004  155 SAAYI--KSGPFDTFVGTIDYAAPEVLRGNPYgGKEQDIWALGVLLYTLVFKENPFYN---------IEEILEADLRIPY 223
                        250       260
                 ....*....|....*....|....*....
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14004  224 AVSEDLIDLISRMLNRDVGDRPTIEELLT 252
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
285-524 1.79e-34

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 130.97  E-value: 1.79e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFE---KIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIIN---------EILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd14073    2 RYElleTLGKGTYGKVKLAIERATGREVAIKSI------KKDKIEDeqdmvrirrEIEIMSSLNHPHIIRIYEVFENKDK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQ 431
Cdd:cd14073   76 IVIVMEYASGGELYDYISERRrLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGL-SNLYSKD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRdf 510
Cdd:cd14073  155 KLLQTFCGSPLYASPEIVNGTPYqGPEVDCWSLGVLLYTLVYGTMPFDGSDFKRLVKQISSGDYREPTQPSDASGLIR-- 232
                        250
                 ....*....|....
gi 578838380 511 lnRCLEMDVDRRGS 524
Cdd:cd14073  233 --WMLTVNPKRRAT 244
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
289-529 1.92e-34

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 130.89  E-value: 1.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEV--AIKQMN------LQQQPKKELIiNEILVMRENKNPNIVNYLDSYLV-GDELWVVMEY 359
Cdd:cd13994    1 IGKGATSVVRIVTKKNPRSGVlyAVKEYRrrddesKRKDYVKRLT-SEYIISSKLHHPNIVKVLDLCQDlHGKWCLVMEY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETcmdeGQIAAVCREC-----LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG--FCAQITPEQS 432
Cdd:cd13994   80 CPGGDLFTLIEKA----DSLSLEEKDCffkqiLRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGtaEVFGMPAEKE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRST--MVGTPYWMAPEVVTRKAYGPK-VDIWSLGIMAIEMVEGEPPY---LNENPLRALY---LIATNGTPELQNPERL 503
Cdd:cd13994  156 SPMSagLCGSEPYMAPEVFTSGSYDGRaVDVWSCGIVLFALFTGRFPWrsaKKSDSAYKAYeksGDFTNGPYEPIENLLP 235
                        250       260
                 ....*....|....*....|....*.
gi 578838380 504 SAVfRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd13994  236 SEC-RRLIYRMLHPDPEKRITIDEAL 260
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
289-526 1.94e-34

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 131.06  E-value: 1.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05611    4 ISKGAFGSVYLAKKRSTGDYFAIKVLKKSDMIAKNQVTNvkaeRAIMMIQGESPYVAKLYYSFQSKDYLYLVMEYLNGGD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYW 443
Cdd:cd05611   84 CASLIkTLGGLPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGL-SRNGLEKRHNKKFVGTPDY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN--GTPELQNpERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd05611  163 LAPETILGVGDDKMSDWWSLGCVIFEFLFGYPPFHAETPDAVFDNILSRriNWPEEVK-EFCSPEAVDLINRLLCMDPAK 241

                 ....*
gi 578838380 522 RGSAK 526
Cdd:cd05611  242 RLGAN 246
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
289-530 2.73e-34

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 130.51  E-value: 2.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILvmrenKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd13995   12 IPRGAFGKVYLAQDTKTKKRMACKLIPVEQFKPSDVEIQACF-----RHENIAELYGALLWEETVHLFMEAGEGGSVLEK 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VtETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 446
Cdd:cd13995   87 L-ESCgpMREFEIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVF-MSTKAVLVDFGLSVQMTEDVYVPKDLRGTEIYMSP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 447 EVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd13995  165 EVILCRGHNTKADIYSLGATIIHMQTGSPPWVRRYPRSAypsyLYIIHKQAPPLEDIAQDCSPAMRELLEAALERNPNHR 244

                 ....*...
gi 578838380 523 GSAKELLQ 530
Cdd:cd13995  245 SSAAELLK 252
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
282-530 2.88e-34

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 130.55  E-value: 2.88e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQM---NLQQQPKKELIIN----EI-LVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd13993    1 RYQLISPIGEGAYGVVYLAVDLRTGRKYAIKCLyksGPNSKDGNDFQKLpqlrEIdLHRRVSRHPNIITLHDVFETEVAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTDVVTETCMDEGQ---IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCaqiTP 429
Cdd:cd13993   81 YIVLEYCPNGDLFEAITENRIYVGKtelIKNVFLQLIDAVKHCHSLGIYHRDIKPENILLSQDeGTVKLCDFGLA---TT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVT-----RKAYGPK-VDIWSLGIMAIEMVEGEPPYLNENPLRALYL-IATNGTPELQNPER 502
Cdd:cd13993  158 EKISMDFGVGSEFYMAPECFDevgrsLKGYPCAaGDIWSLGIILLNLTFGRNPWKIASESDPIFYdYYLNSPNLFDVILP 237
                        250       260
                 ....*....|....*....|....*...
gi 578838380 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd13993  238 MSDDFYNLLRQIFTVNPNNRILLPELQL 265
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
289-515 4.83e-34

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 129.80  E-value: 4.83e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIA-TGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14120    1 IGHGAFAVVFKGRHRKkPDLPVAIKCITKKNLSKsQNLLGKEIKILKELSHENVVALLDCQETSSSVYLVMEYCNGGDLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG---------SVKLTDFGFcAQITPEQSKRST 436
Cdd:cd14120   81 DYLQAkGTLSEDTIRVFLQQIAAAMKALHSKGIVHRDLKPQNILLSHNSgrkpspndiRLKIADFGF-ARFLQDGMMAAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP--LRALYLIATNGTPELqnPERLSAVFRDFLNRC 514
Cdd:cd14120  160 LCGSPMYMAPEVIMSLQYDAKADLWSIGTIVYQCLTGKAPFQAQTPqeLKAFYEKNANLRPNI--PSGTSPALKDLLLGL 237

                 .
gi 578838380 515 L 515
Cdd:cd14120  238 L 238
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
287-531 8.45e-34

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 129.38  E-value: 8.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd08228    8 KKIGRGQFSEVYRATCLLDRKPVALKKVQifeMMDAKARQDCVKEIDLLKQLNHPNVIKYLDSFIEDNELNIVLELADAG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVT-----ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd08228   88 DLSQMIKyfkkqKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE--NPLRALYLIATNGTPELQNpERLSAVFRDFLNRCLE 516
Cdd:cd08228  168 GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDkmNLFSLCQKIEQCDYPPLPT-EHYSEKLRELVSMCIY 246
                        250
                 ....*....|....*
gi 578838380 517 MDVDRRGSAKELLQV 531
Cdd:cd08228  247 PDPDQRPDIGYVHQI 261
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
289-522 9.00e-34

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 130.90  E-value: 9.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII---------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05595    3 LGKGTFGKVILVREKATGRYYAMKIL------RKEVIIakdevahtvTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd05595   77 ANGGELFfHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGITDGATMKTFC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05595  157 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME---EIRFPRTLSPEAKSLLAGLLKKD 233

                 ....
gi 578838380 519 VDRR 522
Cdd:cd05595  234 PKQR 237
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
285-530 1.06e-33

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 129.80  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEKIGQGASGTVYTALDIATGQEVAIKQM--NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAg 362
Cdd:cd06618   19 NLGEIGSGTCGQVYKMRHKKTGHVMAVKQMrrSGNKEENKRILMDLDVVLKSHDCPYIVKCYGYFITDSDVFICMELMS- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 gsltdvvteTCMD-----------EGQIAAVCRECLQALDFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd06618   98 ---------TCLDkllkriqgpipEDILGKMTVSIVKALHYLKEKHgVIHRDVKPSNILLDESGNVKLCDFGISGRLVDS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKrSTMVGTPYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTPELQNPERLSAV 506
Cdd:cd06618  169 KAK-TRSAGCAAYMAPERIDPPdnpKYDIRADVWSLGISLVELATGQFPYrNCKTEFEVLTKILNEEPPSLPPNEGFSPD 247
                        250       260
                 ....*....|....*....|....
gi 578838380 507 FRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06618  248 FCSFVDLCLTKDHRYRPKYRELLQ 271
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
280-511 1.31e-33

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 128.97  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQ-EVAIKQMNLQQQPKKE-LIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14202    1 KFEFSRKDLIGHGAFAVVFKGRHKEKHDlEVAVKCINKKNLAKSQtLLGKEIKILKELKHENIVALYDFQEIANSVYLVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---------VKLTDFGFcAQI 427
Cdd:cd14202   81 EYCNGGDLADYLhTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGrksnpnnirIKIADFGF-ARY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP--LRALYLIATNGTPELqnPERLSA 505
Cdd:cd14202  160 LQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQASSPqdLRLFYEKNKSLSPNI--PRETSS 237

                 ....*.
gi 578838380 506 VFRDFL 511
Cdd:cd14202  238 HLRQLL 243
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
287-530 4.07e-33

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 128.04  E-value: 4.07e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd06622    7 DELGKGNYGSVYKVLHRPTGVTMAMKEIRLElDESKFNQIIMELDILHKAVSPYIVDFYGAFFIEGAVYMCMEYMDAGSL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETC----MDEGQIAAVCRECLQALDFL-HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKrsTMVGT 440
Cdd:cd06622   87 DKLYAGGVategIPEDVLRRITYAVVKGLKFLkEEHNIIHRDVKPTNVLVNGNGQVKLCDFGVSGNLVASLAK--TNIGC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELqnPERLSAVFRDFL 511
Cdd:cd06622  165 QSYMAPERIKsggpnqNPTYTVQSDVWSLGLSILEMALGRYPYPPEtyaNIFAQLSAIVDGDPPTL--PSGYSDDAQDFV 242
                        250
                 ....*....|....*....
gi 578838380 512 NRCLEMDVDRRGSAKELLQ 530
Cdd:cd06622  243 AKCLNKIPNRRPTYAQLLE 261
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
283-539 5.07e-33

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 127.31  E-value: 5.07e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII-NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14169    5 YELKEKLGEGAFSEVVLAQERGSQRLVALKCIPKKALRGKEAMVeNEIAVLRRINHENIVSLEDIYESPTHLYLAMELVT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM---DGSVKLTDFGFCAqiTPEQSKRSTM 437
Cdd:cd14169   85 GGELFDRIIERgSYTEKDASQLIGQVLQAVKYLHQLGIVHRDLKPENLLYATpfeDSKIMISDFGLSK--IEAQGMLSTA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGTPELQNP--ERLSAVFRDFLNRCL 515
Cdd:cd14169  163 CGTPGYVAPELLEQKPYGKAVDVWAIGVISYILLCGYPPFYDENDSE-LFNQILKAEYEFDSPywDDISESAKDFIRHLL 241
                        250       260
                 ....*....|....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQVL-LAGGNSL 539
Cdd:cd14169  242 ERDPEKRFTCEQALQHPwISGDTAL 266
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
283-530 6.30e-33

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 126.53  E-value: 6.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTA--LDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14080    2 YRLGKTIGEGSYSKVKLAeyTKSGLKEKVACKIIDKKKAPKDFLekfLPRELEILRKLRHPNIIQVYSIFERGSKVFIFM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR-- 434
Cdd:cd14080   82 EYAEHGDLLEYIqKRGALSESQARIWFRQLALAVQYLHSLDIAHRDLKCENILLDSNNNVKLSDFGFARLCPDDDGDVls 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKV-DIWSLGIMAIEMVEGEPPYlNENPLRALYLIATN---GTPElqNPERLSAVFRDF 510
Cdd:cd14080  162 KTFCGSAAYAAPEILQGIPYDPKKyDIWSLGVILYIMLCGSMPF-DDSNIKKMLKDQQNrkvRFPS--SVKKLSPECKDL 238
                        250       260
                 ....*....|....*....|
gi 578838380 511 LNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14080  239 IDQLLEPDPTKRATIEEILN 258
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
289-531 6.48e-33

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 128.20  E-value: 6.48e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMREN-KNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05575    3 IGKGSFGKVLLARHKAEGKLYAVKVLQKKAILKRnevKHIMAERNVLLKNvKHPFLVGLHYSFQTKDKLYFVLDYVNGGE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 L-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd05575   83 LfFHLQRERHFPEPRARFYAAEIASALGYLHSLNIIYRDLKPENILLDSQGHVVLTDFGLCKEGIEPSDTTSTFCGTPEY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN-----------PLRalylIATNGTPELqnperlsavfRDFLN 512
Cdd:cd05575  163 LAPEVLRKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRDtaemydnilhkPLR----LRTNVSPSA----------RDLLE 228
                        250       260
                 ....*....|....*....|
gi 578838380 513 RCLEMDVDRR-GSAKELLQV 531
Cdd:cd05575  229 GLLQKDRTKRlGSGNDFLEI 248
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
282-530 6.55e-33

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 126.46  E-value: 6.55e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd08218    1 KYVRIKKIGEGSFGKALLVKSKEDGKQYVIKEINISKMSPKEReeSRKEVAVLSKMKHPNIVQYQESFEENGNLYIVMDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE---TCMDEGQIAA-VCRECLqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
Cdd:cd08218   81 CDGGDLYKRINAqrgVLFPEDQILDwFVQLCL-ALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVLNSTVELAR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGT-PELqnPERLSAVFRDFLNRC 514
Cdd:cd08218  160 TCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGN-MKNLVLKIIRGSyPPV--PSRYSYDLRSLVSQL 236
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd08218  237 FKRNPRDRPSINSILE 252
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
289-530 7.07e-33

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 126.22  E-value: 7.07e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK----KELIINEILVMRENKNPNIVNYLDsYLVGDE---LWVVMEYLA 361
Cdd:cd14119    1 LGEGSYGKVKEVLDTETLCRRAVKILKKRKLRRipngEANVKREIQILRRLNHRNVIKLVD-VLYNEEkqkLYMVMEYCV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GG--SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP--EQSKRSTM 437
Cdd:cd14119   80 GGlqEMLDSAPDKRLPIWQAHGYFVQLIDGLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEALDLfaEDDTCTTS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAY--GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCL 515
Cdd:cd14119  160 QGSPAFQPPEIANGQDSfsGFKVDIWSAGVTLYNMTTGKYPFEGDNIYKLFENIGKG---EYTIPDDVDPDLQDLLRGML 236
                        250
                 ....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQ 530
Cdd:cd14119  237 EKDPEKRFTIEQIRQ 251
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
283-530 7.84e-33

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 127.45  E-value: 7.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIinEILvMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14175    3 YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEI--EIL-LRYGQHPNIITLKDVYDDGKHVYLVTELMRG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL----GMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd14175   80 GELLDkILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYvdesGNPESLRICDFGFAKQLRAENGLLMTP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN---ENPLRALYLIATNG-TPELQNPERLSAVFRDFLNR 513
Cdd:cd14175  160 CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANgpsDTPEEILTRIGSGKfTLSGGNWNTVSDAAKDLVSK 239
                        250
                 ....*....|....*..
gi 578838380 514 CLEMDVDRRGSAKELLQ 530
Cdd:cd14175  240 MLHVDPHQRLTAKQVLQ 256
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
283-530 8.22e-33

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 126.54  E-value: 8.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14114    4 YDILEELGTGAFGVVHRCTERATGNNFAAKFIMTPHESDKETVRKEIQIMNQLHHPKLINLHDAFEDDNEMVLILEFLSG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTmV 438
Cdd:cd14114   84 GELFERIAAEhyKMSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIMCTTKRSneVKLIDFGLATHLDPKESVKVT-T 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRDFLNRCLEM 517
Cdd:cd14114  163 GTAEFAAPEIVEREPVGFYTDMWAVGVLSYVLLSGLSPFAGENDDETLRNVkSCDWNFDDSAFSGISEEAKDFIRKLLLA 242
                        250
                 ....*....|...
gi 578838380 518 DVDRRGSAKELLQ 530
Cdd:cd14114  243 DPNKRMTIHQALE 255
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
287-530 9.39e-33

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 126.23  E-value: 9.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQ----QPKKELIINEILvmreNKNP-----NIVNYLDSYLVGDELWVVM 357
Cdd:cd14133    5 EVLGKGTFGQVVKCYDLLTGEEVALKIIKNNKdyldQSLDEIRLLELL----NKKDkadkyHIVRLKDVFYFKNHLCIVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLaGGSLTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDGS-VKLTDFGFCAQITPEqs 432
Cdd:cd14133   81 ELL-SQNLYEFLKQNKfqyLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLaSYSRCqIKIIDFGSSCFLTQR-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 kRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPelqnPERL-------S 504
Cdd:cd14133  158 -LYSYIQSRYYRAPEVILGLPYDEKIDMWSLGCILAELYTGEPLFPGASEVDQLaRIIGTIGIP----PAHMldqgkadD 232
                        250       260
                 ....*....|....*....|....*.
gi 578838380 505 AVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14133  233 ELFVDFLKKLLEIDPKERPTASQALS 258
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
289-481 1.16e-32

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 127.81  E-value: 1.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05601    9 IGRGHFGEVQVVKEKATGDIYAMKVLKKSETLAQEEVSFfeeERDIMAKANSPWITKLQYAFQDSENLYLVMEYHPGGDL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPY 442
Cdd:cd05601   89 LSLLSryDDIFEESMARFYLAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGSAAKLSSDKTVTSKMpVGTPD 168
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 443 WMAPEVVT------RKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05601  169 YIAPEVLTsmnggsKGTYGVECDWWSLGIVAYEMLYGKTPFTEDT 213
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
289-529 2.12e-32

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 125.23  E-value: 2.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd08221    8 LGRGAFGEAVLYRKTEDNSLVVWKEVNLSRLSEKERrdALNEIDILSLLNHDNIITYYNHFLDGESLFIEMEYCNGGNLH 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd08221   88 DKIAQQKnqlFPEEVVLWYLYQIVSAVSHIHKAGILHRDIKTLNIFLTKADLVKLGDFGISKVLDSESSMAESIVGTPYY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNpERLSAVFRDFLNRCLEMDVDRRG 523
Cdd:cd08221  168 MSPELVQGVKYNFKSDIWAVGCVLYELLTLKRTFDATNPLRLAVKI-VQGEYEDID-EQYSEEIIQLVHDCLHQDPEDRP 245

                 ....*.
gi 578838380 524 SAKELL 529
Cdd:cd08221  246 TAEELL 251
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
287-530 2.36e-32

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 125.90  E-value: 2.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIinEILvMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14178    9 EDIGIGSYSVCKRCVHKATSTEYAVKIIDKSKRDPSEEI--EIL-LRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 D-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL----GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441
Cdd:cd14178   86 DrILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYmdesGNPESIRICDFGFAKQLRAENGLLMTPCYTA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN---ENPLRALYLIATnGTPELQ--NPERLSAVFRDFLNRCLE 516
Cdd:cd14178  166 NFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANgpdDTPEEILARIGS-GKYALSggNWDSISDAAKDIVSKMLH 244
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14178  245 VDPHQRLTAPQVLR 258
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
283-530 4.37e-32

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 124.90  E-value: 4.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd07836    2 FKQLEKLGEGTYATVYKGRNRTTGEIVALKEIHLDaEEGTPSTAIREISLMKELKHENIVRLHDVIHTENKLMLVFEYMD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GG--SLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd07836   82 KDlkKYMDTHGVRGaLDPNTVKSFTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFSNEV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVT-RKAYGPKVDIWSLG-IMAiEMVEGEPPYL---NENPLRALYLIAtnGTPELQN-------PE----- 501
Cdd:cd07836  162 VTLWYRAPDVLLgSRTYSTSIDIWSVGcIMA-EMITGRPLFPgtnNEDQLLKIFRIM--GTPTESTwpgisqlPEykptf 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 578838380 502 -------------RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07836  239 pryppqdlqqlfpHADPLGIDLLHRLLQLNPELRISAHDALQ 280
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
287-529 5.23e-32

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 125.17  E-value: 5.23e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQM--NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEyLAGGS 364
Cdd:cd06616   12 GEIGRGAFGTVNKMLHKPSGTIMAVKRIrsTVDEKEQKRLLMDLDVVMRSSDCPYIVKFYGALFREGDCWICME-LMDIS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDV------VTETCMDEGQIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRSTM 437
Cdd:cd06616   91 LDKFykyvyeVLDSVIPEEILGKIAVATVKALNYLKEElKIIHRDVKPSNILLDRNGNIKLCDFGISGQL--VDSIAKTR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 -VGT-PYwMAPEVVT----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPL-RALYLIATNGTPELQNPERL--SAVFR 508
Cdd:cd06616  169 dAGCrPY-MAPERIDpsasRDGYDVRSDVWSLGITLYEVATGKFPYPKWNSVfDQLTQVVKGDPPILSNSEERefSPSFV 247
                        250       260
                 ....*....|....*....|.
gi 578838380 509 DFLNRCLEMDVDRRGSAKELL 529
Cdd:cd06616  248 NFVNLCLIKDESKRPKYKELL 268
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
287-470 5.52e-32

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 124.33  E-value: 5.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNL-QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd13996   12 ELLGSGGFGSVYKVRNKVDGVTYAIKKIRLtEKSSASEKVLREVKALAKLNHPNIVRYYTAWVEEPPLYIQMELCEGGTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTE----TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQIT------------ 428
Cdd:cd13996   92 RDWIDRrnssSKNDRKLALELFKQILKGVSYIHSKGIVHRDLKPSNIFLDNDdLQVKIGDFGLATSIGnqkrelnnlnnn 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578838380 429 --PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd13996  172 nnGNTSNNSVGIGTPLYASPEQLDGENYNEKADIYSLGIILFEM 215
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
288-530 5.61e-32

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 124.16  E-value: 5.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNlQQQPKKELIINEIL-----VMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14070    9 KLGEGSFAKVREGLHAVTGEKVAIKVID-KKKAKKDSYVTKNLrregrIQQMIRHPNITQLLDILETENSYYLVMELCPG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF--CAQITPEQSKRSTMVG 439
Cdd:cd14070   88 GNLMHRIYDKKrLEEREARRYIRQLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLsnCAGILGYSDPFSTQCG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN-PLRALYLIATNGtpELQN-PERLSAVFRDFLNRCLEM 517
Cdd:cd14070  168 SPAYAAPELLARKKYGPKVDVWSIGVNMYAMLTGTLPFTVEPfSLRALHQKMVDK--EMNPlPTDLSPGAISFLRSLLEP 245
                        250
                 ....*....|...
gi 578838380 518 DVDRRGSAKELLQ 530
Cdd:cd14070  246 DPLKRPNIKQALA 258
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
288-530 6.91e-32

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 123.50  E-value: 6.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQ------PKKELIINEILVMR---ENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14005    7 LLGKGGFGTVYSGVRIRDGLPVAVKFVPKSRVtewamiNGPVPVPLEIALLLkasKPGVPGVIRLLDWYERPDGFLLIME 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGG-SLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGfCAQITpEQSKRS 435
Cdd:cd14005   87 RPEPCqDLFDFITERgALSENLARIIFRQVVEAVRHCHQRGVLHRDIKDENLLINLRtGEVKLIDFG-CGALL-KDSVYT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPK-VDIWSLGIMAIEMVEGEPPYLNEnplraLYLIatngTPELQNPERLSAVFRDFLNRC 514
Cdd:cd14005  165 DFDGTRVYSPPEWIRHGRYHGRpATVWSLGILLYDMLCGDIPFEND-----EQIL----RGNVLFRPRLSKECCDLISRC 235
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd14005  236 LQFDPSKRPSLEQILS 251
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
289-530 7.68e-32

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 125.96  E-value: 7.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII---------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05593   23 LGKGTFGKVILVREKASGKYYAMKIL------KKEVIIakdevahtlTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd05593   97 VNGGELFfHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFC 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05593  177 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---DIKFPRTLSADAKSLLSGLLIKD 253
                        250
                 ....*....|....*..
gi 578838380 519 VDRR-----GSAKELLQ 530
Cdd:cd05593  254 PNKRlgggpDDAKEIMR 270
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
276-511 9.67e-32

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 123.58  E-value: 9.67e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 276 VGDpkKKYTRFEKIGQGASGTVYTALD-IATGQEVAIKQMNLQQQPKKELII-NEILVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd14201    3 VGD--FEYSRKDLVGHGAFAVVFKGRHrKKTDWEVAIKSINKKNLSKSQILLgKEIKILKELQHENIVALYDVQEMPNSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---------VKLTDFGF 423
Cdd:cd14201   81 FLVMEYCNGGDLADYLqAKGTLSEDTIRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRkkssvsgirIKIADFGF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 cAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP--LRALYLIATNGTPELqnPE 501
Cdd:cd14201  161 -ARYLQSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPqdLRMFYEKNKNLQPSI--PR 237
                        250
                 ....*....|
gi 578838380 502 RLSAVFRDFL 511
Cdd:cd14201  238 ETSPYLADLL 247
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
283-530 1.24e-31

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 122.76  E-value: 1.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14079    4 YILGKTLGVGSFGKVKLAEHELTGHKVAVKILNrqkIKSLDMEEKIRREIQILKLFRHPHIIRLYEVIETPTDIFMVMEY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMV 438
Cdd:cd14079   84 VSGGELFDyIVQKGRLSEDEARRFFQQIISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGL-SNIMRDGEFLKTSC 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRDFLNRCLEM 517
Cdd:cd14079  163 GSPNYAAPEVISGKLYaGPEVDVWSCGVILYALLCGSLPFDDEH-IPNLFKKIKSGIYTI--PSHLSPGARDLIKRMLVV 239
                        250
                 ....*....|...
gi 578838380 518 DVDRRGSAKELLQ 530
Cdd:cd14079  240 DPLKRITIPEIRQ 252
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
287-529 1.26e-31

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 123.33  E-value: 1.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMN--------LQQQPKKELIIN-EILVMREN------KNPNIVNYLDSYLVGD 351
Cdd:cd14077    7 KTIGAGSMGKVKLAKHIRTGEKCAIKIIPrasnaglkKEREKRLEKEISrDIRTIREAalssllNHPHICRLRDFLRTPN 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPE 430
Cdd:cd14077   87 HYYMLFEYVDGGQLLDyIISHGKLKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGL-SNLYDP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRD 509
Cdd:cd14077  166 RRLLRTFCGSLYFAAPELLQAQPYtGPEVDVWSFGVVLYVLVCGKVPFDDEN-MPALHAKIKKGKVEY--PSYLSSECKS 242
                        250       260
                 ....*....|....*....|
gi 578838380 510 FLNRCLEMDVDRRGSAKELL 529
Cdd:cd14077  243 LISRMLVVDPKKRATLEQVL 262
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
283-530 1.33e-31

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 123.78  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14085    5 FEIESELGRGATSVVYRCRQKGTQKPYAVKKL--KKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMDEGQIAAVC-RECLQALDFLHSNQVIHRDIKSDNIL---LGMDGSVKLTDFGFcAQITPEQSKRSTMV 438
Cdd:cd14085   83 GELFDRIVEKGYYSERDAADAvKQILEAVAYLHENGIVHRDLKPENLLyatPAPDAPLKIADFGL-SKIVDQQVTMKTVC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP--ERLSAVFRDFLNRCLE 516
Cdd:cd14085  162 GTPGYCAPEILRGCAYGPEVDMWSVGVITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPwwDDVSLNAKDLVKKLIV 241
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14085  242 LDPKKRLTTQQALQ 255
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
279-530 1.39e-31

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 123.77  E-value: 1.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlQQQPK---KELIIneilvMRENKNPNIVNYLDSYLVGDE--- 352
Cdd:cd14137    2 VEISYTIEKVIGSGSFGVVYQAKLLETGEVVAIKKV--LQDKRyknRELQI-----MRRLKHPNIVKLKYFFYSSGEkkd 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 ---LWVVMEYLAGgSLTDVVTETCMDEGQIAAV---------CReclqALDFLHSNQVIHRDIKSDNILL-GMDGSVKLT 419
Cdd:cd14137   75 evyLNLVMEYMPE-TLYRVIRHYSKNKQTIPIIyvklysyqlFR----GLAYLHSLGICHRDIKPQNLLVdPETGVLKLC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 420 DFGFCAQITP-EQSKrsTMVGTPYWMAPEVVTR-KAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLIA-TNGTP 495
Cdd:cd14137  150 DFGSAKRLVPgEPNV--SYICSRYYRAPELIFGaTDYTTAIDIWSAGcVLA-ELLLGQPLFPGESSVDQLVEIIkVLGTP 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 496 ELQ-----NPER------------LSAVFR--------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14137  227 TREqikamNPNYtefkfpqikphpWEKVFPkrtppdaiDLLSKILVYNPSKRLTALEALA 286
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
289-522 1.58e-31

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 123.24  E-value: 1.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTV----------YTALDIATGQEVaIKQMNLQQQPKK--------------ELIINEILVMRENKNPNIVNY- 343
Cdd:cd14118    2 IGKGSYGIVklayneedntLYAMKILSKKKL-LKQAGFFRRPPPrrkpgalgkpldplDRVYREIAILKKLDHPNVVKLv 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 344 --LDSyLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd14118   81 evLDD-PNEDNLYMVFELVDKGAVMEVPTDNPLSEETARSYFRDIVLGIEYLHYQKIIHRDIKPSNLLLGDDGHVKIADF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK-VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQ 498
Cdd:cd14118  160 GVSNEFEGDDALLSSTAGTPAFMAPEALSesRKKFSGKaLDIWAMGVTLYCFVFGRCPFEDDHILGLHEKIKTD---PVV 236
                        250       260
                 ....*....|....*....|....*.
gi 578838380 499 NPER--LSAVFRDFLNRCLEMDVDRR 522
Cdd:cd14118  237 FPDDpvVSEQLKDLILRMLDKNPSER 262
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
237-530 2.10e-31

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 124.94  E-value: 2.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 237 PPSAENANSSTLYRNTDRQRKKSKMTDEeiLEKLRsivsvgdpkkkytrfeKIGQGASGTVYTALDIATGQEVAIKQM-- 314
Cdd:PLN00034  48 PPPSSSSSSSSSSSASGSAPSAAKSLSE--LERVN----------------RIGSGAGGTVYKVIHRPTGRLYALKVIyg 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 315 NLQQQPKKElIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDvvtETCMDEGQIAAVCRECLQALDFLH 394
Cdd:PLN00034 110 NHEDTVRRQ-ICREIEILRDVNHPNVVKCHDMFDHNGEIQVLLEFMDGGSLEG---THIADEQFLADVARQILSGIAYLH 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 395 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV----TRKAY-GPKVDIWSLGIMAIE 469
Cdd:PLN00034 186 RRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERIntdlNHGAYdGYAGDIWSLGVSILE 265
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 470 MVEGEPPY-LNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:PLN00034 266 FYLGRFPFgVGRQGDWASLMCAICMSQPPEAPATASREFRHFISCCLQREPAKRWSAMQLLQ 327
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
289-477 2.52e-31

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 121.45  E-value: 2.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYtaLDIATGQEVAIKQMNLQQQpkkeliiNEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14059    1 LGSGAQGAVF--LGKFRGEEVAVKKVRDEKE-------TDIKHLRKLNHPNIIKFKGVCTQAPCYCILMEYCPYGQLYEV 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 V-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpEQSKRSTMVGTPYWMAPE 447
Cdd:cd14059   72 LrAGREITPSLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELS-EKSTKMSFAGTVAWMAPE 150
                        170       180       190
                 ....*....|....*....|....*....|
gi 578838380 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14059  151 VIRNEPCSEKVDIWSFGVVLWELLTGEIPY 180
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
285-530 3.06e-31

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 123.42  E-value: 3.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFE---KIGQGASGTVYTALDIATGQEVAIK----QMNLQQQPKKELiinEIL-VMRENK---NPNIVNYLDSYLVGDEL 353
Cdd:cd14210   14 RYEvlsVLGKGSFGQVVKCLDHKTGQLVAIKiirnKKRFHQQALVEV---KILkHLNDNDpddKHNIVRYKDSFIFRGHL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEyLAGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFG---FCA 425
Cdd:cd14210   91 CIVFE-LLSINLYELLKSNnfqGLSLSLIRKFAKQILQALQFLHKLNIIHCDLKPENILLkqPSKSSIKVIDFGsscFEG 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPE--QSKrstmvgtpYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN--------------PLRALYLI 489
Cdd:cd14210  170 EKVYTyiQSR--------FYRAPEVILGLPYDTAIDMWSLGCILAELYTGYPLFPGENeeeqlacimevlgvPPKSLIDK 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 490 AT--------NGTPELQNPER----------LSAV-------FRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14210  242 ASrrkkffdsNGKPRPTTNSKgkkrrpgsksLAQVlkcddpsFLDFLKKCLRWDPSERMTPEEALQ 307
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
281-530 3.07e-31

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 122.41  E-value: 3.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14183    6 ERYKVGRTIGDGNFAVVKECVERSTGREYALKIINKSKcRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPTELYLVMEL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGS--VKLTDFGFCAQItpeQSKR 434
Cdd:cd14183   86 VKGGDLFDAITSTNkYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVyeHQDGSksLKLGDFGLATVV---DGPL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATNGTPELQNP--ERLSAVFRDFL 511
Cdd:cd14183  163 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSgDDQEVLFDQILMGQVDFPSPywDNVSDSAKELI 242
                        250
                 ....*....|....*....
gi 578838380 512 NRCLEMDVDRRGSAKELLQ 530
Cdd:cd14183  243 TMMLQVDVDQRYSALQVLE 261
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
289-481 3.39e-31

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 123.37  E-value: 3.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINE-----------ILVMrENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd05591    3 LGKGSFGKVMLAERKGTDEVYAIKVL------KKDVILQDddvdctmtekrILAL-AAKHPFLTALHSCFQTKDRLFFVM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd05591   76 EYVNGGDLMfQIQRARKFDEPRARFYAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGKTTTT 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05591  156 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADN 200
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
283-530 3.90e-31

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 122.82  E-value: 3.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIinEILvMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14177    6 YELKEDIGVGSYSVCKRCIHRATNMEFAVKIIDKSKRDPSEEI--EIL-MRYGQHPNIITLKDVYDDGRYVYLVTELMKG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMD-----GSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd14177   83 GELLDrILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILY-MDdsanaDSIRICDFGFAKQLRGENGLLLT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL---NENPLRALYLIAtNGTPELQ--NPERLSAVFRDFL 511
Cdd:cd14177  162 PCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFAngpNDTPEEILLRIG-SGKFSLSggNWDTVSDAAKDLL 240
                        250
                 ....*....|....*....
gi 578838380 512 NRCLEMDVDRRGSAKELLQ 530
Cdd:cd14177  241 SHMLHVDPHQRYTAEQVLK 259
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
279-529 4.12e-31

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 122.65  E-value: 4.12e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQP--KKELIINEILVMRENKNPNIVNYLDSYLVGDEL 353
Cdd:cd14094    1 FEDVYELCEVIGKGPFSVVRRCIHRETGQQFAVKIVDVakfTSSPglSTEDLKREASICHMLKHPHIVELLETYSSDGML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLT-DVVTET----CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG-MDGS--VKLTDFGFCA 425
Cdd:cd14094   81 YMVFEFMDGADLCfEIVKRAdagfVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLAsKENSapVKLGGFGVAI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENplRALYLIATNGTPELQNPE--RL 503
Cdd:cd14094  161 QLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTK--ERLFEGIIKGKYKMNPRQwsHI 238
                        250       260
                 ....*....|....*....|....*.
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14094  239 SESAKDLVRRMLMLDPAERITVYEAL 264
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
289-532 4.28e-31

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 121.39  E-value: 4.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTAldIATGQEVAIKQMNLQQQpkKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14058    1 VGRGSFGVVCKA--RWRNQIVAVKIIESESE--KKAFEVEVRQLSRVDHPNIIKLYGACSNQKPVCLVMEYAEGGSLYNV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 ----VTETCMDEGQIAAVCRECLQALDFLHSNQ---VIHRDIKSDNILLGMDGSV-KLTDFGFCAQItpeQSKRSTMVGT 440
Cdd:cd14058   77 lhgkEPKPIYTAAHAMSWALQCAKGVAYLHSMKpkaLIHRDLKPPNLLLTNGGTVlKICDFGTACDI---STHMTNNKGS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT--PELQN-PERLsavfRDFLNRCLE 516
Cdd:cd14058  154 AAWMAPEVFEGSKYSEKCDVFSWGIILWEVITRRKPFDHiGGPAFRIMWAVHNGErpPLIKNcPKPI----ESLMTRCWS 229
                        250
                 ....*....|....*.
gi 578838380 517 MDVDRRGSAKELLQVL 532
Cdd:cd14058  230 KDPEKRPSMKEIVKIM 245
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
282-530 5.36e-31

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 121.10  E-value: 5.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14087    2 KYDIKALIGRGSFSRVVRVEHRVTRQPYAIKMIE-TKCRGREVCESELNVLRRVRHTNIIQLIEVFETKERVYMVMELAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFCAQIT--PEQSKRS 435
Cdd:cd14087   81 GGELFDrIIAKGSFTERDATRVLQMVLDGVKYLHGLGITHRDLKPENLLYyhpGPDSKIMITDFGLASTRKkgPNCLMKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TmVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP-ERLSAVFRDFLNRC 514
Cdd:cd14087  161 T-CGTPEYIAPEILLRKPYTQSVDMWAVGVIAYILLSGTMPFDDDNRTRLYRQILRAKYSYSGEPwPSVSNLAKDFIDRL 239
                        250
                 ....*....|....*.
gi 578838380 515 LEMDVDRRGSAKELLQ 530
Cdd:cd14087  240 LTVNPGERLSATQALK 255
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
287-530 5.64e-31

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 121.30  E-value: 5.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENK-NPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd14106   14 TPLGRGKFAVVRKCIHKETGKEYAAKFLRKRRrgQDCRNEILHEIAVLELCKdCPRVVNLHEVYETRSELILILELAAGG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDV-VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG---MDGSVKLTDFGFCAQITPEQSKRStMVG 439
Cdd:cd14106   94 ELQTLlDEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLTsefPLGDIKLCDFGISRVIGEGEEIRE-ILG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGtpELQNPERL----SAVFRDFLNRCL 515
Cdd:cd14106  173 TPDYVAPEILSYEPISLATDMWSIGVLTYVLLTGHSPFGGDDK-QETFLNISQC--NLDFPEELfkdvSPLAIDFIKRLL 249
                        250
                 ....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQ 530
Cdd:cd14106  250 VKDPEKRLTAKECLE 264
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
287-533 7.86e-31

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 120.95  E-value: 7.86e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldIATGQEVAIKQMNLQQQPKKEL--IINEILVMREnKNPNIVNYL---DSYLVGDELWVVMEYLA 361
Cdd:cd13979    9 EPLGSGGFGSVYKA--TYKGETVAVKIVRRRRKNRASRqsFWAELNAARL-RHENIVRVLaaeTGTDFASLGLIIMEYCG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVtetcmDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfCAQITPE---- 430
Cdd:cd13979   86 NGTLQQLI-----YEGSEPLPLAHRILisldiarALRFCHSHGIVHLDVKPANILISEQGVCKLCDFG-CSVKLGEgnev 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER--LSAVFR 508
Cdd:cd13979  160 GTPRSHIGGTYTYRAPELLKGERVTPKADIYSFGITLWQMLTRELPYAGLRQHVLYAVVAKDLRPDLSGLEDseFGQRLR 239
                        250       260
                 ....*....|....*....|....*.
gi 578838380 509 DFLNRCLEMDVDRRGSAK-ELLQVLL 533
Cdd:cd13979  240 SLISRCWSAQPAERPNADeSLLKSLE 265
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
281-529 8.16e-31

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 121.12  E-value: 8.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14097    1 KIYTFGRKLGQGSFGVVIEATHKETQTKWAIKKINREKagSSAVKLLEREVDILKHVNHAHIIHLEEVFETPKRMYLVME 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVT-ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-------GMDGSVKLTDFGFCAQ-ITP 429
Cdd:cd14097   81 LCEDGELKELLLrKGFFSENETRHIIQSLASAVAYLHKNDIVHRDLKLENILVkssiidnNDKLNIKVTDFGLSVQkYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGTPELQNP--ERLSAVF 507
Cdd:cd14097  161 GEDMLQETCGTPIYMAPEVISAHGYSQQCDIWSIGVIMYMLLCGEPPFVAKSE-EKLFEEIRKGDLTFTQSvwQSVSDAA 239
                        250       260
                 ....*....|....*....|..
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14097  240 KNVLQQLLKVDPAHRMTASELL 261
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
281-530 8.61e-31

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 120.40  E-value: 8.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIAT-------GQEVAIKQMNLQQQPKKelIINEI-LVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd14019    1 NKYRIIEKIGEGTFSSVYKAEDKLHdlydrnkGRLVALKHIYPTSSPSR--ILNELeCLERLGGSNNVSGLITAFRNEDQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTEtcMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQ 431
Cdd:cd14019   79 VVAVLPYIEHDDFRDFYRK--MSLTDIRIYLRNLFKALKHVHSFGIIHRDVKPGNFLYNREtGKGVLVDFGLAQREEDRP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGE-PPYLNENPLRALYLIAT-NGTPELQnperlsavfr 508
Cdd:cd14019  157 EQRAPRAGTRGFRAPEVLFKcPHQTTAIDIWSAGVILLSILSGRfPFFFSSDDIDALAEIATiFGSDEAY---------- 226
                        250       260
                 ....*....|....*....|..
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14019  227 DLLDKLLELDPSKRITAEEALK 248
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
336-529 1.16e-30

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 120.16  E-value: 1.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 336 KNPNIVNYLDSYLV---GDELWVV---MEYLAGGSLTDV---VTETCMDegQIAAVCRECLQALDFLHSNQVIHRDIKSD 406
Cdd:cd14012   56 RHPNLVSYLAFSIErrgRSDGWKVyllTEYAPGGSLSELldsVGSVPLD--TARRWTLQLLEALEYLHRNGVVHKSLHAG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 407 NILL---GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP-YWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd14012  134 NVLLdrdAGTGIVKLTDYSLGKTLLDMCSRGSLDEFKQtYWLPPELAQgSKSPTRKTDVWDLGLLFLQMLFGLDVLEKYT 213
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 482 PLRAlyliatngtpeLQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14012  214 SPNP-----------VLVSLDLSASLQDFLSKCLSLDPKKRPTALELL 250
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
287-530 1.50e-30

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 120.02  E-value: 1.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14190   10 EVLGGGKFGKVHTCTEKRTGLKLAAKVINKQNSKDKEMVLLEIQVMNQLNHRNLIQLYEAIETPNEIVLFMEYVEGGELF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 D-VVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQsKRSTMVGTPY 442
Cdd:cd14190   90 ErIVDEDYhLTEVDAMVFVRQICEGIQFMHQMRVLHLDLKPENILCVNRTGhqVKIIDFGLARRYNPRE-KLKVNFGTPE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd14190  169 FLSPEVVNYDQVSFPTDMWSMGVITYMLLSGLSPFLGDDDTETLnNVLMGNWYFDEETFEHVSDEAKDFVSNLIIKERSA 248

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd14190  249 RMSATQCLK 257
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
287-547 1.51e-30

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 120.75  E-value: 1.51e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd06619    7 EILGHGNGGTVYKAYHLLTRRILAVKVIPLDITVElQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 tDVVTEtcMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRSTMVGTPYWMA 445
Cdd:cd06619   87 -DVYRK--IPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLV--NSIAKTYVGTNAYMA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 446 PEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL----NEN---PLRALYLIATNGTPELQNPErLSAVFRDFLNRCLEMD 518
Cdd:cd06619  162 PERISGEQYGIHSDVWSLGISFMELALGRFPYPqiqkNQGslmPLQLLQCIVDEDPPVLPVGQ-FSEKFVHFITQCMRKQ 240
                        250       260
                 ....*....|....*....|....*....
gi 578838380 519 VDRRGSAKELLQVLLAGGNSLHNYAIISM 547
Cdd:cd06619  241 PKERPAPENLMDHPFIVQYNDGNAEVVSM 269
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
289-482 1.53e-30

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 121.02  E-value: 1.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK---KELIINEILVMRENKNPNIVNYLDsylVGDELWVV--------- 356
Cdd:cd13989    1 LGSGGFGYVTLWKHQDTGEYVAIKKCRQELSPSdknRERWCLEVQIMKKLNHPNVVSARD---VPPELEKLspndlplla 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVT--ETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG-MDGSV--KLTDFGFcAQITP 429
Cdd:cd13989   78 MEYCSGGDLRKVLNqpENCcgLKESEVRTLLSDISSAISYLHENRIIHRDLKPENIVLQqGGGRViyKLIDLGY-AKELD 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL-NENP 482
Cdd:cd13989  157 QGSLCTSFVGTLQYLAPELFESKKYTCTVDYWSFGTLAFECITGYRPFLpNWQP 210
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
276-530 1.85e-30

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 120.92  E-value: 1.85e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 276 VGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqqPKKEL------IINEILVMRENKNPNIVNYLDSYLV 349
Cdd:cd14168    5 VEDIKKIFEFKEVLGTGAFSEVVLAEERATGKLFAVKCI-----PKKALkgkessIENEIAVLRKIKHENIVALEDIYES 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 350 GDELWVVMEYLAGGSLTDVVTETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGS-VKLTDFGFcA 425
Cdd:cd14168   80 PNHLYLVMQLVSGGELFDRIVEKGFyTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYfsQDEESkIMISDFGL-S 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRaLYLIATNGTPELQNP--ERL 503
Cdd:cd14168  159 KMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSK-LFEQILKADYEFDSPywDDI 237
                        250       260
                 ....*....|....*....|....*..
gi 578838380 504 SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14168  238 SDSAKDFIRNLMEKDPNKRYTCEQALR 264
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
264-530 1.99e-30

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 122.06  E-value: 1.99e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 264 EEILEKLRSIVSVGDpkkkYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII---------NEILVMRE 334
Cdd:cd05594   12 EVSLTKPKHKVTMND----FEYLKLLGKGTFGKVILVKEKATGRYYAMKIL------KKEVIVakdevahtlTENRVLQN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 335 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIKSDNILLGM 412
Cdd:cd05594   82 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFfHLSRERVFSEDRARFYGAEIVSALDYLHSEKnVVYRDLKLENLMLDK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN 492
Cdd:cd05594  162 DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 578838380 493 gtpELQNPERLSAVFRDFLNRCLEMDVDRR---GS--AKELLQ 530
Cdd:cd05594  242 ---EIRFPRTLSPEAKSLLSGLLKKDPKQRlggGPddAKEIMQ 281
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
280-477 2.00e-30

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 119.67  E-value: 2.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDiATGQEVAIKQMNLQQ-QPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd14161    2 KHRYEFLETLGKGTYGRVKKARD-SSGRLVAIKSIRKDRiKDEQDLlhIRREIEIMSSLNHPHIISVYEVFENSSKIVIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRS 435
Cdd:cd14161   81 MEYASRGDLYDYISERQrLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGL-SNLYNQDKFLQ 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 578838380 436 TMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14161  160 TYCGSPLYASPEIVNGRPYiGPEVDSWSLGVLLYILVHGTMPF 202
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
283-530 2.01e-30

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 120.47  E-value: 2.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpkKELI----INEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd07835    1 YQKLEKIGEGTYGVVYKARDKLTGEIVALKKIRLETE--DEGVpstaIREISLLKELNHPNIVRLLDVVHSENKLYLVFE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGG--SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-------AQITP 429
Cdd:cd07835   79 FLDLDlkKYMDSSPLTGLDPPLIKSYLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGALKLADFGLArafgvpvRTYTH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EqskrstmVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQN-------- 499
Cdd:cd07835  159 E-------VVTLWYRAPEILLgSKHYSTPVDIWSVGCIFAEMVTRRPLFPGDSEIDQLFRIfRTLGTPDEDVwpgvtslp 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 500 ----------PERLSAVF-------RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07835  232 dykptfpkwaRQDLSKVVpsldedgLDLLSQMLVYDPAKRISAKAALQ 279
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
289-530 2.77e-30

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 119.29  E-value: 2.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIK---QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14116   13 LGKGKFGNVYLAREKQSKFILALKvlfKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQiTPeQSKRSTMVGTPYWM 444
Cdd:cd14116   93 YRELQKlSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVH-AP-SSRRTTLCGTLDYL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY---LNENPLRALYLIatngtpELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd14116  171 PPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFeanTYQETYKRISRV------EFTFPDFVTEGARDLISRLLKHNPSQ 244

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd14116  245 RPMLREVLE 253
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
283-486 3.15e-30

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 118.94  E-value: 3.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII---NEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14162    2 YIVGKTLGHGSYAVVKKAYSTKHKCKVAIKIVSKKKAPEDYLQKflpREIEVIKGLKHPNLICFYEAIETTSRVYIIMEL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF-CAQITPEQSKR--- 434
Cdd:cd14162   82 AENGDLLDYIrKNGALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFaRGVMKTKDGKPkls 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKV-DIWSLGIMAIEMVEGEPPYLNENpLRAL 486
Cdd:cd14162  162 ETYCGSYAYASPEILRGIPYDPFLsDIWSMGVVLYTMVYGRLPFDDSN-LKVL 213
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
289-534 3.70e-30

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 119.30  E-value: 3.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALdIATGQEVAIKQMNLQ--QQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14066    1 IGSGGFGTVYKGV-LENGTVVAVKRLNEMncAASKKEFL-TELEMLGRLRHPNLVRLLGYCLESDEKLLVYEYMPNGSLE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETCMDE----GQIAAVCRECLQALDFLHS---NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP--EQSKRSTM 437
Cdd:cd14066   79 DRLHCHKGSPplpwPQRLKIAKGIARGLEYLHEecpPPIIHGDIKSSNILLDEDFEPKLTDFGLARLIPPseSVSKTSAV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYLiatNGTPELQnpERLSAVFRDFLNRCL-E 516
Cdd:cd14066  159 KGTIGYLAPEYIRTGRVSTKSDVYSFGVVLLELLTGKPAV-DENRENASRK---DLVEWVE--SKGKEELEDILDKRLvD 232
                        250
                 ....*....|....*...
gi 578838380 517 MDVDRRGSAKELLQVLLA 534
Cdd:cd14066  233 DDGVEEEEVEALLRLALL 250
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
290-532 4.50e-30

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 118.14  E-value: 4.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 290 GQGASGTVYTALDIATGQEVAIKQMNlqqQPKKELIINEILVMRenknpNIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
Cdd:cd14060    2 GGGSFGSVYRAIWVSQDKEVAVKKLL---KIEKEAEILSVLSHR-----NIIQFYGAILEAPNYGIVTEYASYGSLFDYL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 370 TET---CMDEGQIAAVCRECLQALDFLHSN---QVIHRDIKSDNILLGMDGSVKLTDFGfcAQITPEQSKRSTMVGTPYW 443
Cdd:cd14060   74 NSNeseEMDMDQIMTWATDIAKGMHYLHMEapvKVIHRDLKSRNVVIAADGVLKICDFG--ASRFHSHTTHMSLVGTFPW 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTpELQNPERLSAVFRDFLNRCLEMDVDRRG 523
Cdd:cd14060  152 MAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNE-RPTIPSSCPRSFAELMRRCWEADVKERP 230

                 ....*....
gi 578838380 524 SAKELLQVL 532
Cdd:cd14060  231 SFKQIIGIL 239
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
289-532 5.36e-30

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 118.26  E-value: 5.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTAldIATGQEVAIKQmnLQQQPKKELIINEILVMRENK------NPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14061    2 IGVGGFGKVYRG--IWRGEEVAVKA--ARQDPDEDISVTLENVRQEARlfwmlrHPNIIALRGVCLQPPNLCLVMEYARG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMDEG-------QIAavcreclQALDFLHSNQ---VIHRDIKSDNILLG--------MDGSVKLTDFGFC 424
Cdd:cd14061   78 GALNRVLAGRKIPPHvlvdwaiQIA-------RGMNYLHNEApvpIIHRDLKSSNILILeaienedlENKTLKITDFGLA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 425 AQITpeQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgTPELQNPERLS 504
Cdd:cd14061  151 REWH--KTTRMSAAGTYAWMAPEVIKSSTFSKASDVWSYGVLLWELLTGEVPYKGIDGLAVAYGVAVN-KLTLPIPSTCP 227
                        250       260
                 ....*....|....*....|....*...
gi 578838380 505 AVFRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14061  228 EPFAQLMKDCWQPDPHDRPSFADILKQL 255
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
289-522 7.50e-30

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 119.77  E-value: 7.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII---------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05571    3 LGKGTFGKVILCREKATGELYAIKIL------KKEVIIakdevahtlTENRVLQNTRHPFLTSLKYSFQTNDRLCFVMEY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd05571   77 VNGGELfFHLSRERVFSEDRTRFYGAEIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKEEISYGATTKTFC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05571  157 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNRDHEVLFELILME---EVRFPSTLSPEAKSLLAGLLKKD 233

                 ....
gi 578838380 519 VDRR 522
Cdd:cd05571  234 PKKR 237
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
288-477 9.46e-30

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 117.82  E-value: 9.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14075    9 ELGSGNFSQVKLGIHQLTKEKVAIKILDKTKldQKTQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYASGGEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQsKRSTMVGTPYWM 444
Cdd:cd14075   89 yTKISTEGKLSESEAKPLFAQIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHAKRGE-TLNTFCGSPPYA 167
                        170       180       190
                 ....*....|....*....|....*....|....
gi 578838380 445 APEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14075  168 APELFKDEHYiGIYVDIWALGVLLYFMVTGVMPF 201
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
289-526 9.87e-30

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 119.30  E-value: 9.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05603    3 IGKGSFGKVLLAKRKCDGKFYAVKVLQkktiLKKKEQNHIMAERNVLLKNLKHPFLVGLHYSFQTSEKLYFVLDYVNGGE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 L-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ-ITPEQSKrSTMVGTPY 442
Cdd:cd05603   83 LfFHLQRERCFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEgMEPEETT-STFCGTPE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELQNPERLSAVfrDFLNRCLEMDVDRR 522
Cdd:cd05603  162 YLAPEVLRKEPYDRTVDWWCLGAVLYEMLYGLPPFYSRD-VSQMYDNILHKPLHLPGGKTVAAC--DLLQGLLHKDQRRR 238

                 ....
gi 578838380 523 GSAK 526
Cdd:cd05603  239 LGAK 242
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
278-529 1.13e-29

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 117.73  E-value: 1.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPK--KKYTRFEKIGQGASGTVYTALDIATGQ----EVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNYLDSYLVGD 351
Cdd:cd14187    2 DPRtrRRYVRGRFLGKGGFAKCYEITDADTKEvfagKIVPKSLLLKPH-QKEKMSMEIAIHRSLAHQHVVGFHGFFEDND 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDV-VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd14187   81 FVYVVLELCRRRSLLELhKRRKALTEPEARYYLRQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEYD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYL-IATNgtpELQNPERLSAVFRD 509
Cdd:cd14187  161 GERKKTLCGTPNYIAPEVLSKKGHSFEVDIWSIGCIMYTLLVGKPPF-ETSCLKETYLrIKKN---EYSIPKHINPVAAS 236
                        250       260
                 ....*....|....*....|
gi 578838380 510 FLNRCLEMDVDRRGSAKELL 529
Cdd:cd14187  237 LIQKMLQTDPTARPTINELL 256
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
287-530 1.51e-29

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 117.13  E-value: 1.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIK---QMNLQQQPKKELIiNEILVMRENKNPNIVNYldsYLVGD---ELWVVMEYL 360
Cdd:cd14074    9 ETLGRGHFAVVKLARHVFTGEKVAVKvidKTKLDDVSKAHLF-QEVRCMKLVQHPNVVRL---YEVIDtqtKLYLILELG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQsKRSTM 437
Cdd:cd14074   85 DGGDMYDYIMkhENGLNEDLARKYFRQIVSAISYCHKLHVVHRDLKPENVVFfEKQGLVKLTDFGFSNKFQPGE-KLETS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELqnPERLSAVFRDFLNRCLE 516
Cdd:cd14074  164 CGSLAYSAPEILLGDEYdAPAVDIWSLGVILYMLVCGQPPFQEANDSETLTMI-MDCKYTV--PAHVSPECKDLIRRMLI 240
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14074  241 RDPKKRASLEEIEN 254
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
289-532 1.80e-29

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 117.36  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14221    1 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VTEtcMDE----GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT--------------PE 430
Cdd:cd14221   81 IKS--MDShypwSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMVdektqpeglrslkkPD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM---VEGEPPYLnenPLRALYLIATNGTPELQNPERLSAVF 507
Cdd:cd14221  159 RKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIigrVNADPDYL---PRTMDFGLNVRGFLDRYCPPNCPPSF 235
                        250       260
                 ....*....|....*....|....*
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14221  236 FPIAVLCCDLDPEKRPSFSKLEHWL 260
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
287-530 1.82e-29

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 117.00  E-value: 1.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKEliiNEI-LVMRENKNPNIVNYLDSY--LVGDE--LWVVMEYLA 361
Cdd:cd14089    7 QVLGLGINGKVLECFHKKTGEKFALKV--LRDNPKAR---REVeLHWRASGCPHIVRIIDVYenTYQGRkcLLVVMECME 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFcAQITPEQSKRS 435
Cdd:cd14089   82 GGELFSRIQERAdsaFTEREAAEIMRQIGSAVAHLHSMNIAHRDLKPENLLYsskGPNAILKLTDFGF-AKETTTKKSLQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLG-IMAIeMVEGEPPYLNENPLRalylIA-------TNGTPELQNPE--RLSA 505
Cdd:cd14089  161 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGvIMYI-LLCGYPPFYSNHGLA----ISpgmkkriRNGQYEFPNPEwsNVSE 235
                        250       260
                 ....*....|....*....|....*
gi 578838380 506 VFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14089  236 EAKDLIRGLLKTDPSERLTIEEVMN 260
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
281-477 1.96e-29

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 116.95  E-value: 1.96e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIK---QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14189    1 RSYCKGRLLGKGGFARCYEMTDLATNKTYAVKvipHSRVAKPHQREKIVNEIELHRDLHHKHVVKFSHHFEDAENIYIFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDV-VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd14189   81 ELCSRKSLAHIwKARHTLLEPEVRYYLKQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARLEPPEQRKKT 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14189  161 ICGTPNYLAPEVLLRQGHGPESDVWSLGCVMYTLLCGNPPF 201
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
289-529 2.41e-29

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 116.50  E-value: 2.41e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14186    9 LGKGSFACVYRARSLHTGLEVAIKMIDkkaMQKAGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd14186   89 SRYLKNRKkpFTEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHFTMCGTPNY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMDVDRRG 523
Cdd:cd14186  169 ISPEIATRSAHGLESDVWSLGCMFYTLLVGRPPFDTDTVKNTLNKVVLA---DYEMPAFLSREAQDLIHQLLRKNPADRL 245

                 ....*.
gi 578838380 524 SAKELL 529
Cdd:cd14186  246 SLSSVL 251
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
289-529 3.54e-29

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 116.42  E-value: 3.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVMEYLAGGS 364
Cdd:cd14165    9 LGEGSYAKVKSAYSERLKCNVAIKIIDKKKAPDDfveKFLPRELEILARLNHKSIIKTYEIFETSDgKVYIVMELGVQGD 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVT-ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR----STMVG 439
Cdd:cd14165   89 LLEFIKlRGALPEDVARKMFHQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRCLRDENGRivlsKTFCG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKV-DIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPER--LSAVFRDFLNRCLE 516
Cdd:cd14165  169 SAAYAAPEVLQGIPYDPRIyDIWSLGVILYIMVCGSMPYDDSNVKKMLKIQKEH---RVRFPRSknLTSECKDLIYRLLQ 245
                        250
                 ....*....|...
gi 578838380 517 MDVDRRGSAKELL 529
Cdd:cd14165  246 PDVSQRLCIDEVL 258
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
289-478 4.23e-29

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 116.45  E-value: 4.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14154    1 LGKGFFGQAIKVTHRETGEVMVMKELIRFDEEAQRNFLKEVKVMRSLDHPNVLKFIGVLYKDKKLNLITEYIPGGTLKDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VTEtcMDE----GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-------------------- 424
Cdd:cd14154   81 LKD--MARplpwAQRVRFAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLArliveerlpsgnmspsetlr 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 425 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM---VEGEPPYL 478
Cdd:cd14154  159 HLKSPDRKKRYTVVGNPYWMAPEMLNGRSYDEKVDIFSFGIVLCEIigrVEADPDYL 215
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
278-533 4.65e-29

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 117.81  E-value: 4.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFE---KIGQGASGTVYTALDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 350
Cdd:cd05602    1 NPHAKPSDFHflkVIGKGSFGKVLLARHKSDEKFYAVKVLQkkaiLKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd05602   81 DKLYFVLDYINGGELfYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENplralyliatngTPELqnperlsavFRD 509
Cdd:cd05602  161 PNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN------------TAEM---------YDN 219
                        250       260
                 ....*....|....*....|....
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQVLL 533
Cdd:cd05602  220 ILNKPLQLKPNITNSARHLLEGLL 243
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
283-530 4.74e-29

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 116.55  E-value: 4.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKELI----INEILVMRENKNPNIVNyLDSYLVG---DELWV 355
Cdd:cd07843    7 YEKLNRIEEGTYGVVYRARDKKTGEIVALKK--LKMEKEKEGFpitsLREINILLKLQHPNIVT-VKEVVVGsnlDKIYM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGgSLTDVVTEtcMDE----GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd07843   84 VMEYVEH-DLKSLMET--MKQpflqSEVKCLMLQLLSGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAREYGSPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-------------------- 489
Cdd:cd07843  161 KPYTQLVVTLWYRAPELLLgAKEYSTAIDMWSVGcIFA-ELLTKKPLFPGKSEIDQLNKIfkllgtptekiwpgfselpg 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 490 ATNGTPELQNPERLSAVFR---------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07843  240 AKKKTFTKYPYNQLRKKFPalslsdngfDLLNRLLTYDPAKRISAEDALK 289
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
286-525 5.01e-29

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 116.35  E-value: 5.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEK---IGQGASGTVYTALDIATGQEVAIKQMN-----LQQQPKKELIINEILVMRENknPNIVNYLDSYLVGDELWVVM 357
Cdd:cd05609    2 FETiklISNGAYGAVYLVRHRETRQRFAMKKINkqnliLRNQIQQVFVERDILTFAEN--PFVVSMYCSFETKRHLCMVM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGG---SLTDVVTETCMDEGQIAAVcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG------------ 422
Cdd:cd05609   80 EYVEGGdcaTLLKNIGPLPVDMARMYFA--ETVLALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGlskiglmslttn 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 423 ----FCAQITPEQSKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGtpELQ 498
Cdd:cd05609  158 lyegHIEKDTREFLDKQ-VCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP-EELFGQVISD--EIE 233
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 499 NPER---LSAVFRDFLNRCLEMD-VDRRGSA 525
Cdd:cd05609  234 WPEGddaLPDDAQDLITRLLQQNpLERLGTG 264
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
283-496 5.25e-29

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 116.45  E-value: 5.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd07860    2 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEgvPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGG--SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-AQITPEQSKRSTM 437
Cdd:cd07860   82 HQDlkKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLArAFGVPVRTYTHEV 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 438 VgTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPE 496
Cdd:cd07860  162 V-TLWYRAPEILLgCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIfRTLGTPD 221
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
287-481 6.52e-29

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 115.59  E-value: 6.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE--LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14082    9 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKLRFPTKQesQLRNEVAILQQLSHPGVVNLECMFETPERVFVVMEKLHGDM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFcAQITPEQSKRSTMVG 439
Cdd:cd14082   89 LEMILSSEKgrLPERITKFLVTQILVALRYLHSKNIVHCDLKPENVLLASAEPfpqVKLCDFGF-ARIIGEKSFRRSVVG 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYlNEN 481
Cdd:cd14082  168 TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPF-NED 208
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
283-522 1.05e-28

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 116.65  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlqqqpKKELIINE----------ILVmrENKNPNIVNYLDSYLVGDE 352
Cdd:cd05598    3 FEKIKTIGVGAFGEVSLVRKKDTNALYAMKTLR-----KKDVLKRNqvahvkaerdILA--EADNEWVVKLYYSFQDKEN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETCMDEGQIAavcR----ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd05598   76 LYFVMDYIPGGDLMSLLIKKGIFEEDLA---RfyiaELVCAIESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFR 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 -PEQSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNPE--R 502
Cdd:cd05598  153 wTHDSKYylaHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMLVGQPPFLAQTPAETQLKV-INWRTTLKIPHeaN 231
                        250       260
                 ....*....|....*....|
gi 578838380 503 LSAVFRDFLNRcLEMDVDRR 522
Cdd:cd05598  232 LSPEAKDLILR-LCCDAEDR 250
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
287-482 1.19e-28

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 119.90  E-value: 1.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILVMR---ENKN------PNIVNYLDsylVGDE---LW 354
Cdd:NF033483  13 ERIGRGGMAEVYLAKDTRLDRDVAVKVL------RPDLARDPEFVARfrrEAQSaaslshPNIVSVYD---VGEDggiPY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTEtcmdEG-----QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG---FCAQ 426
Cdd:NF033483  84 IVMEYVDGRTLKDYIRE----HGplspeEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGiarALSS 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 427 ITPEQSkrSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:NF033483 160 TTMTQT--NSVLGTVHYLSPEQARGGTVDARSDIYSLGIVLYEMLTGRPPFDGDSP 213
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
282-530 1.37e-28

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 116.09  E-value: 1.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL----QQQPKKelIINEILVMRENKNPNIVNYLD-----SYLVGDE 352
Cdd:cd07834    1 RYELLKPIGSGAYGVVCSAYDKRTGRKVAIKKISNvfddLIDAKR--ILREIKILRHLKHENIIGLLDilrppSPEEFND 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYL---------AGGSLTDVVTETCMdeGQIaavcrecLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd07834   79 VYIVTELMetdlhkvikSPQPLTDDHIQYFL--YQI-------LRGLKYLHSAGVIHRDLKPSNILVNSNCDLKICDFGL 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 CAQITPEQSKRsTM---VGTPYWMAPEVV-TRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTPEL 497
Cdd:cd07834  150 ARGVDPDEDKG-FLteyVVTRWYRAPELLlSSKKYTKAIDIWSVGcIFA-ELLTRKPLFPGRDYIDQLNLIvEVLGTPSE 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 498 QN--------------------PERLSAVF-------RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07834  228 EDlkfissekarnylkslpkkpKKPLSEVFpgaspeaIDLLEKMLVFNPKKRITADEALA 287
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
285-529 1.39e-28

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 114.40  E-value: 1.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ-------QQPKKELIINEILvmreNKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd13997    4 ELEQIGSGSFSEVFKVRSKVDGCLYAVKKSKKPfrgpkerARALREVEAHAAL----GQHPNIVRYYSSWEEGGHLYIQM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTE----TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeqsk 433
Cdd:cd13997   80 ELCENGSLQDALEElspiSKLSEAEVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLE----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 RSTMV--GTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPpyLNEN-----PLRALYLiatngtPELQNPeRLSA 505
Cdd:cd13997  155 TSGDVeeGDSRYLAPELLNeNYTHLPKADIFSLGVTVYEAATGEP--LPRNgqqwqQLRQGKL------PLPPGL-VLSQ 225
                        250       260
                 ....*....|....*....|....
gi 578838380 506 VFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd13997  226 ELTRLLKVMLDPDPTRRPTADQLL 249
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
283-530 1.40e-28

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 114.46  E-value: 1.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE--LIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVMEY 359
Cdd:cd08223    2 YQFLRVIGKGSYGEVWLVRHKRDRKQYVIKKLNLKNASKRErkAAEQEAKLLSKLKHPNIVSYKESFEGEDgFLYIVMGF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd08223   82 CEGGDLYTRLKEqkgVLLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARVLESSSDMATT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRAL-YLIATNGTPELqnPERLSAVFRDFLNRCL 515
Cdd:cd08223  162 LIGTPYYMSPELFSNKPYNHKSDVWALGCCVYEMATLKHAF-NAKDMNSLvYKILEGKLPPM--PKQYSPELGELIKAML 238
                        250
                 ....*....|....*
gi 578838380 516 EMDVDRRGSAKELLQ 530
Cdd:cd08223  239 HQDPEKRPSVKRILR 253
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
289-532 1.46e-28

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 114.41  E-value: 1.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATgqeVAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLdSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14062    1 IGSGSFGTVYKGRWHGD---VAVKKLNVTDPTPSQLQAfkNEVAVLRKTRHVNILLFM-GYMTKPQLAIVTQWCEGSSLY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT----PEQSKRSTmvGT 440
Cdd:cd14062   77 KHlhVLETKFEMLQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGLATVKTrwsgSQQFEQPT--GS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQN-----PERLSAVFRDf 510
Cdd:cd14062  155 ILWMAPEVIRMQdenPYSFQSDVYAFGIVLYELLTGQLPYSHINNRDQILFMVGRGylRPDLSKvrsdtPKALRRLMED- 233
                        250       260
                 ....*....|....*....|..
gi 578838380 511 lnrCLEMDVDRRGSAKELLQVL 532
Cdd:cd14062  234 ---CIKFQRDERPLFPQILASL 252
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
280-530 1.54e-28

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 116.40  E-value: 1.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEK-IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-----KELI---------INEILVMRENKNPNIVNYL 344
Cdd:PTZ00024   7 SERYIQKGAhLGEGTYGKVEKAYDTLTGKIVAIKKVKIIEISNdvtkdRQLVgmcgihfttLRELKIMNEIKHENIMGLV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 345 DSYLVGDELWVVMEYLAGgSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:PTZ00024  87 DVYVEGDFINLVMDIMAS-DLKKVVdRKIRLTESQVKCILLQILNGLNVLHKWYFMHRDLSPANIFINSKGICKIADFGL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 -----CAQITPEQSKRSTM---------VGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL 488
Cdd:PTZ00024 166 arrygYPPYSDTLSKDETMqrreemtskVVTLWYRAPELLMgAEKYHFAVDMWSVGCIFAELLTGKPLFPGENEIDQLGR 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 489 I-ATNGTPELQN-----------------PERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:PTZ00024 246 IfELLGTPNEDNwpqakklplyteftprkPKDLKTIFPnasddaiDLLQSLLKLNPLERISAKEALK 312
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
284-530 1.93e-28

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 115.54  E-value: 1.93e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEK---IGQGASGTVYTALDIATGQEVAIKQMNLQQQpkKELI----INEILVMRENKNPNIVNYLDsYLVGDEL--- 353
Cdd:cd07845    7 TEFEKlnrIGEGTYGIVYRARDTTSGEIVALKKVRMDNE--RDGIpissLREITLLLNLRHPNIVELKE-VVVGKHLdsi 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEY----LAggSLTDVVTeTCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd07845   84 FLVMEYceqdLA--SLLDNMP-TPFSESQVKCLMLQLLRGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLARTYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTP---------ELQ 498
Cdd:cd07845  161 PAKPMTPKVVTLWYRAPELLLgCTTYTTAIDMWAVGCILAELLAHKPLLPGKSEIEQLDLIIQLlGTPnesiwpgfsDLP 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 499 NPER-----------------LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07845  241 LVGKftlpkqpynnlkhkfpwLSEAGLRLLNFLLMYDPKKRATAEEALE 289
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
289-481 1.94e-28

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 115.77  E-value: 1.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILV---MRENK-------NPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05590    3 LGKGSFGKVMLARLKESGRLYAVKVL------KKDVILQDDDVectMTEKRilslarnHPFLTQLYCCFQTPDRLFFVME 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05590   77 FVNGGDLMFHIQKSRrFDEARARFYAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIFNGKTTSTF 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05590  157 CGTPDYIAPEILQEMLYGPSVDWWAMGVLLYEMLCGHAPFEAEN 200
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
289-477 2.14e-28

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 115.48  E-value: 2.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELII--NEI----------LVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd05589    7 LGRGHFGKVLLAEYKPTGELFAIKAL------KKGDIIarDEVeslmcekrifETVNSARHPFLVNLFACFQTPEHVCFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSL-----TDVVTETcmdEGQIAAVCreCLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd05589   81 MEYAAGGDLmmhihEDVFSEP---RAVFYAAC--VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFG 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05589  156 DRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGESPF 201
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
289-522 2.25e-28

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 115.56  E-value: 2.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINE-----ILVMRE-----NKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05592    3 LGKGSFGKVMLAELKGTNQYFAIKAL------KKDVVLEDddvecTMIERRvlalaSQHPFLTHLFCTFQTESHLFFVME 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05592   77 YLNGGDLMfHIQQSGRFDEDRARFYGAEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKENIYGENKASTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGTPELqnPERLSAVFRDFLNRCLEM 517
Cdd:cd05592  157 CGTPDYIAPEILKGQKYNQSVDWWSFGVLLYEMLIGQSPFHGEDE-DELFWSICNDTPHY--PRWLTKEAASCLSLLLER 233

                 ....*
gi 578838380 518 DVDRR 522
Cdd:cd05592  234 NPEKR 238
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
288-530 4.65e-28

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 113.49  E-value: 4.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMR-ENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14197   16 ELGRGKFAVVRKCVEKDSGKEFAAKFMRKRRkgQDCRMEIIHEIAVLElAQANPWVINLHEVYETASEMILVLEYAAGGE 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD---GSVKLTDFGFCAQITPEQSKRSTMv 438
Cdd:cd14197   96 IFNQCVadrEEAFKEKDVKRLMKQILEGVSFLHNNNVVHLDLKPQNILLTSEsplGDIKIVDFGLSRILKNSEELREIM- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEM 517
Cdd:cd14197  175 GTPEYVAPEILSYEPISTATDMWSIGVLAYVMLTGISPFLGDDKQETFLNISQmNVSYSEEEFEHLSESAIDFIKTLLIK 254
                        250
                 ....*....|...
gi 578838380 518 DVDRRGSAKELLQ 530
Cdd:cd14197  255 KPENRATAEDCLK 267
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
287-477 6.96e-28

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 113.28  E-value: 6.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEI-LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14090    8 ELLGEGAYASVQTCINLYTGKEYAVKIIEKHPGHSRSRVFREVeTLHQCQGHPNILQLIEYFEDDERFYLVFEKMRGGPL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFCAQI-----------TPE 430
Cdd:cd14090   88 LSHIEKrVHFTEQEASLVVRDIASALDFLHDKGIAHRDLKPENILCESMDKvspVKICDFDLGSGIklsstsmtpvtTPE 167
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 431 QskrSTMVGTPYWMAPEVV---TRKA--YGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14090  168 L---LTPVGSAEYMAPEVVdafVGEAlsYDKRCDLWSLGVILYIMLCGYPPF 216
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
289-477 7.07e-28

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 114.25  E-value: 7.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILV---MRENK-------NPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05619   13 LGKGSFGKVFLAELKGTNQFFAIKAL------KKDVVLMDDDVectMVEKRvlslaweHPFLTHLFCTFQTKENLFFVME 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVtETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd05619   87 YLNGGDLMFHI-QSChkFDLPRATFYAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTST 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05619  166 FCGTPDYIAPEILLGQKYNTSVDWWSFGVLLYEMLIGQSPF 206
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
289-522 1.22e-27

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 113.12  E-value: 1.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILV---MRENK-------NPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05620    3 LGKGSFGKVLLAELKGKGEYFAVKAL------KKDVVLIDDDVectMVEKRvlalaweNPFLTHLYCTFQTKEHLFFVME 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05620   77 FLNGGDLMFHIQDKGrFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENVFGDNRASTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgTPELqnPERLSAVFRDFLNRCLEM 517
Cdd:cd05620  157 CGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD-TPHY--PRWITKESKDILEKLFER 233

                 ....*
gi 578838380 518 DVDRR 522
Cdd:cd05620  234 DPTRR 238
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
287-530 1.24e-27

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 111.98  E-value: 1.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14192   10 EVLGGGRFGQVHKCTELSTGLTLAAKIIKVKGAKEREEVKNEINIMNQLNHVNLIQLYDAFESKTNLTLIMEYVDGGELF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETCMDEGQIAAV--CRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFGFCAQITPEQsKRSTMVGTPY 442
Cdd:cd14192   90 DRITDESYQLTELDAIlfTRQICEGVHYLHQHYILHLDLKPENILCvnSTGNQIKIIDFGLARRYKPRE-KLKVNFGTPE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd14192  169 FLAPEVVNYDFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMnNIVNCKWDFDAEAFENLSEEAKDFISRLLVKEKSC 248

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd14192  249 RMSATQCLK 257
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
281-549 1.36e-27

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 113.82  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd05610    4 EEFVIVKPISRGAFGKVYLGRKKNNSKLYAVKVVKKADMINKNMvhqVQAERDALALSKSPFIVHLYYSLQSANNVYLVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC------------ 424
Cdd:cd05610   84 EYLIGGDVKSLLhIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSkvtlnrelnmmd 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 425 ------------------AQI----------------TPEQSKRST-------MVGTPYWMAPEVVTRKAYGPKVDIWSL 463
Cdd:cd05610  164 ilttpsmakpkndysrtpGQVlslisslgfntptpyrTPKSVRRGAarvegerILGTPDYLAPELLLGKPHGPAVDWWAL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 464 GIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLAGGNSLHNYA 543
Cdd:cd05610  244 GVCLFEFLTGIPPFNDETPQQVFQNILNRDIPWPEGEEELSVNAQNAIEILLTMDPTKRAGLKELKQHPLFHGVDWENLQ 323

                 ....*.
gi 578838380 544 IISMAF 549
Cdd:cd05610  324 NQTMPF 329
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
283-530 1.43e-27

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 112.03  E-value: 1.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK------KELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd14194    7 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSsrrgvsREDIEREVSILKEIQHPNVITLHEVYENKTDVILI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSV-----KLTDFGFCAQITPE 430
Cdd:cd14194   87 LELVAGGELFDFLAEKeSLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIML-LDRNVpkpriKIIDFGLAHKIDFG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRD 509
Cdd:cd14194  166 NEFKN-IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVsAVNYEFEDEYFSNTSALAKD 244
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14194  245 FIRRLLVKDPKKRMTIQDSLQ 265
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
282-528 1.93e-27

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 111.98  E-value: 1.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTV----------YTALDIATGQEVaIKQMNLQQQPKK-----------------ELIINEILVMRE 334
Cdd:cd14199    3 QYKLKDEIGKGSYGVVklayneddntYYAMKVLSKKKL-MRQAGFPRRPPPrgaraapegctqprgpiERVYQEIAILKK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 335 NKNPNIVNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 412
Cdd:cd14199   82 LDHPNVVKLVEVLddPSEDHLYMVFELVKQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDVKPSNLLVGE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV--TRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNEnplRALYLI 489
Cdd:cd14199  162 DGHIKIADFGVSNEFEGSDALLTNTVGTPAFMAPETLseTRKIFsGKALDVWAMGVTLYCFVFGQCPFMDE---RILSLH 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 490 ATNGTPELQNPER--LSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd14199  239 SKIKTQPLEFPDQpdISDDLKDLLFRMLDKNPESRISVPEI 279
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
281-530 2.40e-27

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 110.87  E-value: 2.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIK---QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd14188    1 KRYCRGKVLGKGGFAKCYEMTDLTTNKVYAAKiipHSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd14188   81 EYCSRRSMAHILkARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAARLEPLEHRRRT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELqnPERLSAVFRDFLNRCLE 516
Cdd:cd14188  161 ICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTN-LKETYRCIREARYSL--PSSLLAPAKHLIASMLS 237
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14188  238 KNPEDRPSLDEIIR 251
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
289-481 2.84e-27

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 112.10  E-value: 2.84e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEILV---MRE-------NKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05587    4 LGKGSFGKVMLAERKGTDELYAIKIL------KKDVIIQDDDVectMVEkrvlalsGKPPFLTQLHSCFQTMDRLYFVME 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ-ITPEQSKRsT 436
Cdd:cd05587   78 YVNGGDLMyHIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEgIFGGKTTR-T 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05587  157 FCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 201
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
283-530 3.02e-27

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 112.81  E-value: 3.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIinEILvMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14176   21 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI--EIL-LRYGQHPNIITLKDVYDDGKYVYVVTELMKG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL----GMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd14176   98 GELLDkILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYvdesGNPESIRICDFGFAKQLRAENGLLMTP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN---ENPLRALYLIATnGTPELQNP--ERLSAVFRDFLN 512
Cdd:cd14176  178 CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANgpdDTPEEILARIGS-GKFSLSGGywNSVSDTAKDLVS 256
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14176  257 KMLHVDPHQRLTAALVLR 274
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
289-481 3.27e-27

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 112.36  E-value: 3.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05604    4 IGKGSFGKVLLAKRKRDGKYYAVKVLQkkviLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTDKLYFVLDFVNGGE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd05604   84 LFfHLQRERSFPEPRARFYAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEGISNSDTTTTFCGTPEY 163
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05604  164 LAPEVIRKQPYDNTVDWWCLGSVLYEMLYGLPPFYCRD 201
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
283-530 4.70e-27

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 110.27  E-value: 4.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVA---IKQMNLQQQPK---KELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd14105    7 YDIGEELGSGQFAVVKKCREKSTGLEYAakfIKKRRSKASRRgvsREDIEREVSILRQVLHPNIITLHDVFENKTDVVLI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSV-----KLTDFGFCAQITPE 430
Cdd:cd14105   87 LELVAGGELFDFLAEKeSLSEEEATEFLKQILDGVNYLHTKNIAHFDLKPENIML-LDKNVpipriKLIDFGLAHKIEDG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNP--ERLSAVFR 508
Cdd:cd14105  166 NEFKN-IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI-TAVNYDFDDEyfSNTSELAK 243
                        250       260
                 ....*....|....*....|..
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14105  244 DFIRQLLVKDPRKRMTIQESLR 265
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
289-477 5.11e-27

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 109.79  E-value: 5.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14071    8 IGKGNFAVVKLARHRITKTEVAIKIIDKSQLDEENLkkIYREVQIMKMLNHPHIIKLYQVMETKDMLYLVTEYASNGEIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 D-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQsKRSTMVGTPYWMA 445
Cdd:cd14071   88 DyLAQHGRMSEKEARKKFWQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPGE-LLKTWCGSPPYAA 166
                        170       180       190
                 ....*....|....*....|....*....|...
gi 578838380 446 PEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14071  167 PEVFEGKEYeGPQLDIWSLGVVLYVLVCGALPF 199
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
287-529 7.14e-27

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 110.01  E-value: 7.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVA---IKQMNLQQQPKKElIINEILVMRENK-NPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14198   14 KELGRGKFAVVRQCISKSTGQEYAakfLKKRRRGQDCRAE-ILHEIAVLELAKsNPRVVNLHEVYETTSEIILILEYAAG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD---GSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd14198   93 GEIFNLCVPDLAEmvsENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSIyplGDIKIVDFGMSRKIGHACELREI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MvGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCL 515
Cdd:cd14198  173 M-GTPEYLAPEILNYDPITTATDMWNIGVIAYMLLTHESPFVGEdNQETFLNISQVNVDYSEETFSSVSQLATDFIQKLL 251
                        250
                 ....*....|....
gi 578838380 516 EMDVDRRGSAKELL 529
Cdd:cd14198  252 VKNPEKRPTAEICL 265
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
282-477 9.62e-27

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 109.29  E-value: 9.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ------QQPKKELIIneilvMRENKNPNIVNYLDSYLVGDELWV 355
Cdd:cd08219    1 QYNVLRVVGEGSFGRALLVQHVNSDQKYAMKEIRLPksssavEDSRKEAVL-----LAKMKHPNIVAFKESFEADGHLYI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd08219   76 VMEYCDGGDLMQKIKLQrgkLFPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLTSPGA 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 433 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd08219  156 YACTYVGTPYYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPF 200
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
278-529 1.81e-26

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 109.77  E-value: 1.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnLQQQPKKELIIN---EILVMRENKNPNIVNYL---------- 344
Cdd:cd07865    9 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQIVALKKV-LMENEKEGFPITalrEIKILQLLKHENVVNLIeicrtkatpy 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 345 -----DSYLVgdelwvvMEY----LAGGSLTDVVTetcMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS 415
Cdd:cd07865   88 nrykgSIYLV-------FEFcehdLAGLLSNKNVK---FTLSEIKKVMKMLLNGLYYIHRNKILHRDMKAANILITKDGV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 416 VKLTDFG----FCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI 489
Cdd:cd07865  158 LKLADFGlaraFSLAKNSQPNRYTNRVVTLWYRPPELLLgERDYGPPIDMWGAGcIMA-EMWTRSPIMQGNTEQHQLTLI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 490 AT---NGTPEL----------------QN-----PERLSAVFR-----DFLNRCLEMDVDRRGSAKELL 529
Cdd:cd07865  237 SQlcgSITPEVwpgvdklelfkkmelpQGqkrkvKERLKPYVKdpyalDLIDKLLVLDPAKRIDADTAL 305
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
287-532 2.64e-26

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 107.91  E-value: 2.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05041    1 EKIGRGNFGDVYRGVLKPDNTEVAVKtcRETLPPDLKRKFL-QEARILKQYDHPNIVKLIGVCVQKQPIMIVMELVPGGS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ-ITPEQSKRSTMVGTP 441
Cdd:cd05041   80 LLTFLrkKGARLTVKQLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMSREeEDGEYTVSDGLKQIP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 Y-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGtpELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:cd05041  160 IkWTAPEALNYGRYTSESDVWSFGILLWEIFSlGATPYPGMSNQQTREQIESGY--RMPAPELCPEAVYRLMLQCWAYDP 237
                        250
                 ....*....|...
gi 578838380 520 DRRGSAKELLQVL 532
Cdd:cd05041  238 ENRPSFSEIYNEL 250
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
286-530 2.65e-26

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 109.06  E-value: 2.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKI---GQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd06615    3 FEKLgelGAGNGGVVTKVLHRPSGLIMARKLIHLEIKPAiRNQIIRELKVLHECNSPYIVGFYGAFYSDGEISICMEHMD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRSTMVG 439
Cdd:cd06615   83 GGSLDQVLKKAGrIPENILGKISIAVLRGLTYLREKhKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEG-------------------EPPYLNENPLRALYLIATNGTP----- 495
Cdd:cd06615  161 TRSYMSPERLQGTHYTVQSDIWSLGLSLVEMAIGrypipppdakeleamfgrpVSEGEAKESHRPVSGHPPDSPRpmaif 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 496 EL------QNPERL-----SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd06615  241 ELldyivnEPPPKLpsgafSDEFQDFVDKCLKKNPKERADLKELTK 286
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
289-530 2.69e-26

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 107.74  E-value: 2.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD- 367
Cdd:cd14115    1 IGRGRFSIVKKCLHKATRKDVAVKFVSKKMK-KKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILVLELMDDGRLLDy 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 -VVTETCMDEgQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD---GSVKLTDFGFCAQITPEQsKRSTMVGTPYW 443
Cdd:cd14115   80 lMNHDELMEE-KVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRipvPRVKLIDLEDAVQISGHR-HVHHLLGNPEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAtngTPELQNPER----LSAVFRDFLNRCLEMDV 519
Cdd:cd14115  158 AAPEVIQGTPVSLATDIWSIGVLTYVMLSGVSPFLDESKEETCINVC---RVDFSFPDEyfgdVSQAARDFINVILQEDP 234
                        250
                 ....*....|.
gi 578838380 520 DRRGSAKELLQ 530
Cdd:cd14115  235 RRRPTAATCLQ 245
STKc_ROCK cd05596
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
289-480 3.53e-26

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK is also referred to as Rho-associated kinase or simply as Rho kinase. It contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain. It is activated via interaction with Rho GTPases and is involved in many cellular functions including contraction, adhesion, migration, motility, proliferation, and apoptosis. The ROCK subfamily consists of two isoforms, ROCK1 and ROCK2, which may be functionally redundant in some systems, but exhibit different tissue distributions. Both isoforms are ubiquitously expressed in most tissues, but ROCK2 is more prominent in brain and skeletal muscle while ROCK1 is more pronounced in the liver, testes, and kidney. Studies in knockout mice result in different phenotypes, suggesting that the two isoforms do not compensate for each other during embryonic development. The ROCK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270747 [Multi-domain]  Cd Length: 352  Bit Score: 109.77  E-value: 3.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05596   34 IGRGAFGEVQLVRHKSTKKVYAMKLLSKFEMIKRSdsaFFWEERDIMAHANSEWIVQLHYAFQDDKYLYMVMDYMPGGDL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-TMVGTPYWM 444
Cdd:cd05596  114 VNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFVHRDVKPDNMLLDASGHLKLADFGTCMKMDKDGLVRSdTAVGTPDYI 193
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578838380 445 APEVVTRKA----YGPKVDIWSLGIMAIEMVEGEPPYLNE 480
Cdd:cd05596  194 SPEVLKSQGgdgvYGRECDWWSVGVFLYEMLVGDTPFYAD 233
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
297-527 3.59e-26

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 107.80  E-value: 3.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 297 VYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCM 374
Cdd:cd14088   17 IFRAKDKTTGKLYTCKKFLKRDGRKvRKAAKNEINILKMVKHPNILQLVDVFETRKEYFIFLELATGREVFDwILDQGYY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 375 DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG---MDGSVKLTDFGFcAQItpEQSKRSTMVGTPYWMAPEVVTR 451
Cdd:cd14088   97 SERDTSNVIRQVLEAVAYLHSLKIVHRNLKLENLVYYnrlKNSKIVISDFHL-AKL--ENGLIKEPCGTPEYLAPEVVGR 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 452 KAYGPKVDIWSLGIMAIEMVEGEPPYLN-------ENPLRALYLIATNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRR 522
Cdd:cd14088  174 QRYGRPVDCWAIGVIMYILLSGNPPFYDeaeeddyENHDKNLFRKILAGDYEFDSPywDDISQAAKDLVTRLMEVEQDQR 253

                 ....*
gi 578838380 523 GSAKE 527
Cdd:cd14088  254 ITAEE 258
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
289-522 3.80e-26

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 107.86  E-value: 3.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIA---TGQEVAIKQMN----LQQQPKKELIINEILVM-RENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd05583    2 LGTGAYGKVFLVRKVGghdAGKLYAMKVLKkatiVQKAKTAEHTMTERQVLeAVRQSPFLVTLHYAFQTDAKLHLILDYV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-TMV 438
Cdd:cd05583   82 NGGELfTHLYQREHFTESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFLPGENDRAySFC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRK--AYGPKVDIWSLGIMAIEMVEGEPPYLNENplralyliATNGTPELQN---------PERLSAVF 507
Cdd:cd05583  162 GTIEYMAPEVVRGGsdGHDKAVDWWSLGVLTYELLTGASPFTVDG--------ERNSQSEISKrilkshppiPKTFSAEA 233
                        250
                 ....*....|....*
gi 578838380 508 RDFLNRCLEMDVDRR 522
Cdd:cd05583  234 KDFILKLLEKDPKKR 248
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
288-530 4.02e-26

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 108.13  E-value: 4.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRE-NKNPNIVNYLDsyLVGDE----LWVVMEyLA 361
Cdd:cd07831    6 KIGEGTFSEVLKAQSRKTGKYYAIKCMKKHFKSLEQVNnLREIQALRRlSPHPNILRLIE--VLFDRktgrLALVFE-LM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSVKLTDFGFCAQITPEQSkRSTMVG 439
Cdd:cd07831   83 DMNLYELIKgrKRPLPEKRVKNYMYQLLKSLDHMHRNGIFHRDIKPENILI-KDDILKLADFGSCRGIYSKPP-YTEYIS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPE-VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP-----ELQNPER---------- 502
Cdd:cd07831  161 TRWYRAPEcLLTDGYYGPKMDIWAVGCVFFEILSLFPLFPGTNELDQIAKIhDVLGTPdaevlKKFRKSRhmnynfpskk 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 578838380 503 ----------LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07831  241 gtglrkllpnASAEGLDLLKKLLAYDPDERITAKQALR 278
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
286-529 4.26e-26

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 108.99  E-value: 4.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKI---GQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd06650    7 FEKIselGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAiRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFL-HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRSTMVG 439
Cdd:cd06650   87 GGSLDQVLKKAGrIPEQILGKVSIAVIKGLTYLrEKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM----------------------VEGEP---PYLNENPLRALYLIATNGT 494
Cdd:cd06650  165 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMavgrypipppdakelelmfgcqVEGDAaetPPRPRTPGRPLSSYGMDSR 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 495 PEL-----------QNPERL-----SAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd06650  245 PPMaifelldyivnEPPPKLpsgvfSLEFQDFVNKCLIKNPAERADLKQLM 295
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
289-479 4.35e-26

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 108.08  E-value: 4.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLD-----SYLVGDELWVVMEYLAG 362
Cdd:cd14039    1 LGTGGFGNVCLYQNQETGEKIAIKSCRLELSVKnKDRWCHEIQIMKKLNHPNVVKACDvpeemNFLVNDVPLLAMEYCSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVT--ETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV---KLTDFGFcAQITPEQSKRS 435
Cdd:cd14039   81 GDLRKLLNkpENCcgLKESQVLSLLSDIGSGIQYLHENKIIHRDLKPENIVLQEINGKivhKIIDLGY-AKDLDQGSLCT 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN 479
Cdd:cd14039  160 SFVGTLQYLAPELFENKSYTVTVDYWSFGTMVFECIAGFRPFLH 203
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
289-522 4.99e-26

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 108.43  E-value: 4.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIIN---------EILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05585    2 IGKGSFGKVMQVRKKDTSRIYALKTI------RKAHIVSrsevthtlaERTVLAQVDCPFIVPLKFSFQSPEKLYLVLAF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd05585   76 INGGELfHHLQREGRFDLSRARFYTAELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMKDDDKTNTFC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgtpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05585  156 GTPEYLAPELLLGHGYTKAVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILQE---PLRFPDGFDRDAKDLLIGLLNRD 232

                 ....
gi 578838380 519 VDRR 522
Cdd:cd05585  233 PTKR 236
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
289-522 5.81e-26

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 107.18  E-value: 5.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIAT-----GQEVAIKQM---NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14076    9 LGEGEFGKVKLGWPLPKanhrsGVQVAIKLIrrdTQQENCQTSKIMREINILKGLTHPNIVRLLDVLKTKKYIGIVLEFV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETCMDEGQIAavCR---ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK-RST 436
Cdd:cd14076   89 SGGELFDYILARRRLKDSVA--CRlfaQLISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFANTFDHFNGDlMST 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPE-VVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLN--ENP----LRALYLIATNgTPeLQNPERLSAVFR 508
Cdd:cd14076  167 SCGSPCYAAPElVVSDSMYaGRKADIWSCGVILYAMLAGYLPFDDdpHNPngdnVPRLYRYICN-TP-LIFPEYVTPKAR 244
                        250
                 ....*....|....
gi 578838380 509 DFLNRCLEMDVDRR 522
Cdd:cd14076  245 DLLRRILVPNPRKR 258
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
287-530 6.19e-26

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 106.92  E-value: 6.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd14193   10 EILGGGRFGQVHKCEEKSSGLKLAAKIIKARSQKEKEEVKNEIEVMNQLNHANLIQLYDAFESRNDIVLVMEYVDGGELF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL-LGMDGS-VKLTDFGFCAQITPEQSKRSTMvGTPY 442
Cdd:cd14193   90 DRIIDENynLTELDTILFIKQICEGIQYMHQMYILHLDLKPENILcVSREANqVKIIDFGLARRYKPREKLRVNF-GTPE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDR 521
Cdd:cd14193  169 FLAPEVVNYEFVSFPTDMWSLGVIAYMLLSGLSPFLGEDDNETLnNILACQWDFEDEEFADISEEAKDFISKLLIKEKSW 248

                 ....*....
gi 578838380 522 RGSAKELLQ 530
Cdd:cd14193  249 RMSASEALK 257
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
279-482 7.20e-26

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 106.83  E-value: 7.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14111    1 PQKPYTFLDEKARGRFGVIRRCRENATGKNFPAKIVPYQAE-EKQGVLQEYEILKSLHHERIMALHEAYITPRYLVLIAE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGS-LTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR-ST 436
Cdd:cd14111   80 FCSGKElLHSLIDRFRYSEDDVVGYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQSFNPLSLRQlGR 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:cd14111  160 RTGTLEYMAPEMVKGEPVGPPADIWSIGVLTYIMLSGRSPFEDQDP 205
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
282-482 8.86e-26

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 106.61  E-value: 8.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14665    1 RYELVKDIGSGNFGVARLMRDKQTKELVAVKYIE-RGEKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgmDGS----VKLTDFGFCAQITPEQSKRST 436
Cdd:cd14665   80 GGELFERICNAGrFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLL--DGSpaprLKICDFGYSKSSVLHSQPKST 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 437 mVGTPYWMAPEVVTRKAYGPKV-DIWSLGIMAIEMVEGEPPYlnENP 482
Cdd:cd14665  158 -VGTPAYIAPEVLLKKEYDGKIaDVWSCGVTLYVMLVGAYPF--EDP 201
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
289-533 9.19e-26

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 109.71  E-value: 9.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEliinEILVMRENKNPnIVN----YLDS--YLVGDE--LWVVMEYL 360
Cdd:cd05624   80 IGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRA----ETACFREERNV-LVNgdcqWITTlhYAFQDEnyLYLVMDYY 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM- 437
Cdd:cd05624  155 VGGDLLTLLSkfEDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVa 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRK-----AYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELQNPERLSAVFRDfln 512
Cdd:cd05624  235 VGTPDYISPEILQAMedgmgKYGPECDWWSLGVCMYEMLYGETPFYAES-LVETYGKIMNHEERFQFPSHVTDVSEE--- 310
                        250       260
                 ....*....|....*....|.
gi 578838380 513 rclemdvdrrgsAKELLQVLL 533
Cdd:cd05624  311 ------------AKDLIQRLI 319
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
281-530 9.23e-26

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 108.53  E-value: 9.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlqqQPKKELI-----INEILVMRENKNPNIVNYLDSYLVGDEL-- 353
Cdd:cd07851   15 DRYQNLSPVGSGAYGQVCSAFDTKTGRKVAIKKLS---RPFQSAIhakrtYRELRLLKHMKHENVIGLLDVFTPASSLed 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 ----WVVMEyLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItp 429
Cdd:cd07851   92 fqdvYLVTH-LMGADLNNIVKCQKLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHT-- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 eQSKRSTMVGTPYWMAPEVV-TRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTP--EL------- 497
Cdd:cd07851  169 -DDEMTGYVATRWYRAPEIMlNWMHYNQTVDIWSVGcIMA-ELLTGKTLFPGSDHIDQLKRImNLVGTPdeELlkkisse 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 498 --QN-----PER----LSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07851  247 saRNyiqslPQMpkkdFKEVFSganplaiDLLEKMLVLDPDKRITAAEALA 297
STKc_NDR_like_fungal cd05629
Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs ...
289-530 9.27e-26

Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group is composed of fungal NDR-like proteins including Saccharomyces cerevisiae CBK1 (or CBK1p), Schizosaccharomyces pombe Orb6 (or Orb6p), Ustilago maydis Ukc1 (or Ukc1p), and Neurospora crassa Cot1. Like NDR kinase, group members contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. CBK1 is an essential component in the RAM (regulation of Ace2p activity and cellular morphogenesis) network. CBK1 and Orb6 play similar roles in coordinating cell morphology with cell cycle progression. Ukc1 is involved in morphogenesis, pathogenicity, and pigment formation. Cot1 plays a role in polar tip extension.The fungal NDR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270778 [Multi-domain]  Cd Length: 377  Bit Score: 109.17  E-value: 9.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05629    9 IGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMFKKDQLAHvkaERDVLAESDSPWVVSLYYSFQDAQYLYLIMEFLPGGDL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA------------------Q 426
Cdd:cd05629   89 mTMLIKYDTFSEDVTRFYMAECVLAIEAVHKLGFIHRDIKPDNILIDRGGHIKLSDFGLSTgfhkqhdsayyqkllqgkS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 427 ITPEQSKRSTM-----------------------------VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05629  169 NKNRIDNRNSVavdsinltmsskdqiatwkknrrlmaystVGTPDYIAPEIFLQQGYGQECDWWSLGAIMFECLIGWPPF 248
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 478 LNENPlRALYLIATNGTPELQNPE--RLSAVFRDFLNRCLEMDVDR--RGSAKELLQ 530
Cdd:cd05629  249 CSENS-HETYRKIINWRETLYFPDdiHLSVEAEDLIRRLITNAENRlgRGGAHEIKS 304
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
283-530 1.27e-25

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 106.24  E-value: 1.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14191    4 YDIEERLGSGKFGQVFRLVEKKTKKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEMVSG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMD--EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFGFCAQITPEQSKRsTMV 438
Cdd:cd14191   84 GELFERIIDEDFEltERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCvnKTGTKIKLIDFGLARRLENAGSLK-VLF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTNGTPELQNP--ERLSAVFRDFLNRCLE 516
Cdd:cd14191  163 GTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV-TSATWDFDDEafDEISDDAKDFISNLLK 241
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14191  242 KDMKARLTCTQCLQ 255
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
289-481 1.28e-25

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 107.78  E-value: 1.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDS-YLVGDELWVVMEYLAGGS 364
Cdd:cd05616    8 LGKGSFGKVMLAERKGTDELYAVKILKkdvVIQDDDVECTMVEKRVLALSGKPPFLTQLHScFQTMDRLYFVMEYVNGGD 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd05616   88 LMYHIQQVGrFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 167
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05616  168 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 205
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
353-513 1.31e-25

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 107.49  E-value: 1.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd05582   72 LYLILDFLRGGDLfTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHE 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI--ATNGTPELQNPER---LSAV 506
Cdd:cd05582  152 KKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMTMIlkAKLGMPQFLSPEAqslLRAL 231

                 ....*...
gi 578838380 507 F-RDFLNR 513
Cdd:cd05582  232 FkRNPANR 239
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
282-522 1.48e-25

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 106.25  E-value: 1.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIK--QMNLQ-QQPKKELII----NEILVMRENKNPNIVNYLDSYLVG-DEL 353
Cdd:cd13990    1 RYLLLNLLGKGGFSEVYKAFDLVEQRYVACKihQLNKDwSEEKKQNYIkhalREYEIHKSLDHPRIVKLYDVFEIDtDSF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLtDVVTETC--MDEGQIAAVCRECLQALDFL--HSNQVIHRDIKSDNILLG---MDGSVKLTDFGFCAQ 426
Cdd:cd13990   81 CTVLEYCDGNDL-DFYLKQHksIPEREARSIIMQVVSALKYLneIKPPIIHYDLKPGNILLHsgnVSGEIKITDFGLSKI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 427 ITPEQSKRSTM------VGTPYWMAPEVVTRKAYGP----KVDIWSLGIMAIEMVEGEPPY-LNENPLRalylIATNGTP 495
Cdd:cd13990  160 MDDESYNSDGMeltsqgAGTYWYLPPECFVVGKTPPkissKVDVWSVGVIFYQMLYGRKPFgHNQSQEA----ILEENTI 235
                        250       260       270
                 ....*....|....*....|....*....|...
gi 578838380 496 ----ELQNPER--LSAVFRDFLNRCLEMDVDRR 522
Cdd:cd13990  236 lkatEVEFPSKpvVSSEAKDFIRRCLTYRKEDR 268
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
289-532 1.54e-25

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 105.65  E-value: 1.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKelIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14065    1 LGKGFFGEVYKVTHRETGKVMVMKELKRFDEQRS--FLKEVKLMRRLSHPNILRFIGVCVKDNKLNFITEYVNGGTLEEL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VTEtcMDE----GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVK---LTDFGFCAQI------TPEQSKRS 435
Cdd:cd14065   79 LKS--MDEqlpwSQRVSLAKDIASGMAYLHSKNIIHRDLNSKNCLVREANRGRnavVADFGLAREMpdektkKPDRKKRL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM---VEGEPPYLnenPLRALYLIATNGTPELQN---PERlsavFRD 509
Cdd:cd14065  157 TVVGSPYWMAPEMLRGESYDEKVDVFSFGIVLCEIigrVPADPDYL---PRTMDFGLDVRAFRTLYVpdcPPS----FLP 229
                        250       260
                 ....*....|....*....|...
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14065  230 LAIRCCQLDPEKRPSFVELEHHL 252
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
289-471 1.69e-25

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 106.18  E-value: 1.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14222    1 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKRLNLLTEFIEGGTLKDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 V--TETCMDEgQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ--------------- 431
Cdd:cd14222   81 LraDDPFPWQ-QKVSFAKGIASGMAYLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEEKkkpppdkpttkkrtl 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 432 -----SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV 471
Cdd:cd14222  160 rkndrKKRYTVVGNPYWMAPEMLNGKSYDEKVDIFSFGIVLCEII 204
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
281-475 1.84e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 106.27  E-value: 1.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQE-VAIKQMNLQQQPKKELI--INEILVMRE---NKNPNIVNYLDSYLVG---- 350
Cdd:cd07862    1 QQYECVAEIGEGAYGKVFKARDLKNGGRfVALKRVRVQTGEEGMPLstIREVAVLRHletFEHPNVVRLFDVCTVSrtdr 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 -DELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQI 427
Cdd:cd07862   81 eTKLTLVFEHVDQDLTTylDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARI 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 428 TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd07862  160 YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKP 207
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
282-475 1.90e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 106.20  E-value: 1.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI--INEILVMR---ENKNPNIVNYLD---SYLVGDEL 353
Cdd:cd07863    1 QYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVQTNEDGLPLstVREVALLKrleAFDHPNIVRLMDvcaTSRTDRET 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WV--VMEYLAGGSLT--DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITP 429
Cdd:cd07863   81 KVtlVFEHVDQDLRTylDKVPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGL-ARIYS 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd07863  160 CQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKP 205
STKc_Sid2p_like cd05600
Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the ...
288-528 1.99e-25

Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group contains fungal kinases including Schizosaccharomyces pombe Sid2p and Saccharomyces cerevisiae Dbf2p. Group members show similarity to NDR kinases in that they contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Sid2p plays a crucial role in the septum initiation network (SIN) and in the initiation of cytokinesis. Dbf2p is important in regulating the mitotic exit network (MEN) and in cytokinesis. The Sid2p-like group is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270751 [Multi-domain]  Cd Length: 386  Bit Score: 108.20  E-value: 1.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05600   18 QVGQGGYGSVFLARKKDTGEICALKIMKkkvLFKLNEVNHVLTERDILTTTNSPWLVKLLYAFQDPENVYLAMEYVPGGD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ------------ 431
Cdd:cd05600   98 FRTLLNNSgILSEEHARFYIAEMFAAISSLHQLGYIHRDLKPENFLIDSSGHIKLTDFGLASGTLSPKkiesmkirleev 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 -------------------------SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY----LNENP 482
Cdd:cd05600  178 kntafleltakerrniyramrkedqNYANSVVGSPDYMAPEVLRGEGYDLTVDYWSLGCILFECLVGFPPFsgstPNETW 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 483 LRALYLIATNGTPELQNPER---LSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd05600  258 ANLYHWKKTLQRPVYTDPDLefnLSDEAWDLITKLITDPQDRLQSPEQI 306
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
289-477 2.27e-25

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 105.72  E-value: 2.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14117   14 LGKGKFGNVYLAREKQSKFIVALKVLFKSQIEKEGVehqLRREIEIQSHLRHPNILRLYNYFHDRKRIYLILEYAPRGEL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQiTPEQsKRSTMVGTPYWM 444
Cdd:cd14117   94 YKELQKHGrFDEQRTATFMEELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGWSVH-APSL-RRRTMCGTLDYL 171
                        170       180       190
                 ....*....|....*....|....*....|...
gi 578838380 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14117  172 PPEMIEGRTHDEKVDLWCIGVLCYELLVGMPPF 204
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
279-529 2.34e-25

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 105.53  E-value: 2.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTAldiATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLdSYLVGDELWVV 356
Cdd:cd14151    6 PDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLqaFKNEVGVLRKTRHVNILLFM-GYSTKPQLAIV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQS-- 432
Cdd:cd14151   82 TQWCEGSSLYHHlhIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGL-ATVKSRWSgs 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 -KRSTMVGTPYWMAPEVVTRKAYGP---KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQN-----PE 501
Cdd:cd14151  161 hQFEQLSGSILWMAPEVIRMQDKNPysfQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGylSPDLSKvrsncPK 240
                        250       260
                 ....*....|....*....|....*...
gi 578838380 502 RLSAVFRDflnrCLEMDVDRRGSAKELL 529
Cdd:cd14151  241 AMKRLMAE----CLKKKRDERPLFPQIL 264
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
289-481 2.58e-25

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 107.00  E-value: 2.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMRENKNPNIVNYLDS-YLVGDELWVVMEYLAGGS 364
Cdd:cd05615   18 LGKGSFGKVMLAERKGSDELYAIKILKkdvVIQDDDVECTMVEKRVLALQDKPPFLTQLHScFQTVDRLYFVMEYVNGGD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 443
Cdd:cd05615   98 LMYHIQQVGkFKEPQAVFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMVEGVTTRTFCGTPDY 177
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05615  178 IAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGED 215
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
283-470 3.25e-25

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 105.53  E-value: 3.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKI---GQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd14046    5 LTDFEELqvlGKGAFGQVVKVRNKLDGRYYAIKKIKLRsESKNNSRILREVMLLSRLNHQHVVRYYQAWIERANLYIQME 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG-----FCAQITPEQS 432
Cdd:cd14046   85 YCEKSTLRDLIDSgLFQDTDRLWRLFRQILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGlatsnKLNVELATQD 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 433 KRST-------------MVGTPYWMAPEVV--TRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd14046  165 INKStsaalgssgdltgNVGTALYVAPEVQsgTKSTYNEKVDMYSLGIIFFEM 217
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
283-530 3.50e-25

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 105.46  E-value: 3.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD-----ELWVVM 357
Cdd:cd13986    2 YRIQRLLGEGGFSFVYLVEDLSTGRLYALKKILCHSKEDVKEAMREIENYRLFNHPNILRLLDSQIVKEaggkkEVYLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVtETCMDEG------QIAAVCRECLQALDFLHSNQ---VIHRDIKSDNILLGMDGSVKLTDFGFC--AQ 426
Cdd:cd13986   82 PYYKRGSLQDEI-ERRLVKGtffpedRILHIFLGICRGLKAMHEPElvpYAHRDIKPGNVLLSEDDEPILMDLGSMnpAR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 427 ITPEQSKRSTMV-------GTPYWMAPEVVTRKAYG---PKVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTP 495
Cdd:cd13986  161 IEIEGRREALALqdwaaehCTMPYRAPELFDVKSHCtidEKTDIWSLGCTLYALMYGESPFeRIFQKGDSLALAVLSGNY 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 578838380 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd13986  241 SFPDNSRYSEELHQLVKSMLVVNPAERPSIDDLLS 275
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
287-522 3.65e-25

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 105.50  E-value: 3.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQM---NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd08229   30 KKIGRGQFSEVYRATCLLDGVPVALKKVqifDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAG 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVV-----TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd08229  110 DLSRMIkhfkkQKRLIPEKTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE--NPLRALYLIATNGTPELQNpERLSAVFRDFLNRCLE 516
Cdd:cd08229  190 GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDkmNLYSLCKKIEQCDYPPLPS-DHYSEELRQLVNMCIN 268

                 ....*.
gi 578838380 517 MDVDRR 522
Cdd:cd08229  269 PDPEKR 274
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
275-529 3.65e-25

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 106.67  E-value: 3.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlqqQPKKELI-----INEILVMRENKNPNIVNYLDSYLV 349
Cdd:cd07878    9 TVWEVPERYQNLTPVGSGAYGSVCSAYDTRLRQKVAVKKLS---RPFQSLIharrtYRELRLLKHMKHENVIGLLDVFTP 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 350 G------DELWVVMEyLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd07878   86 AtsienfNEVYLVTN-LMGADLNNIVKCQKLSDEHVQFLIYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 CAQITPEQSKrstMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEP-----PYLNEnpLRALYLIATNGTPEL 497
Cdd:cd07878  165 ARQADDEMTG---YVATRWYRAPEIMLNwMHYNQTVDIWSVGCIMAELLKGKAlfpgnDYIDQ--LKRIMEVVGTPSPEV 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 498 -----------------QNPER-LSAVFR-------DFLNRCLEMDVDRRGSAKELL 529
Cdd:cd07878  240 lkkisseharkyiqslpHMPQQdLKKIFRganplaiDLLEKMLVLDSDKRISASEAL 296
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
282-495 3.86e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 105.19  E-value: 3.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd07861    1 DYTKIEKIGEGTYGVVYKGRNKKTGQIVAMKKIRLESEEEgvPSTAIREISLLKELQHPNIVCLEDVLMQENRLYLVFEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LA---GGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd07861   81 LSmdlKKYLDSLPKGKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTH 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 437 MVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP 495
Cdd:cd07861  161 EVVTLWYRAPEVLLGSPrYSTPVDIWSIGTIFAEMATKKPLFHGDSEIDQLFRIfRILGTP 221
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
289-534 4.52e-25

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 104.90  E-value: 4.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGDEL-------WVVMEYL 360
Cdd:cd14036    8 IAEGGFAFVYEAQDVGTGKEYALKRLLSNEEEKNKAIIQEINFMKKlSGHPNIVQFCSAASIGKEEsdqgqaeYLLLTEL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTE----TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQS 432
Cdd:cd14036   88 CKGQLVDFVKKveapGPFSPDTVLKIFYQTCRAVQHMHKQSppIIHRDLKIENLLIGNQGQIKLCDFGSATTEahYPDYS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 ----KRS------TMVGTPYWMAPEVV---TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALyliatNGTPELQN 499
Cdd:cd14036  168 wsaqKRSlvedeiTRNTTPMYRTPEMIdlySNYPIGEKQDIWALGCILYLLCFRKHPFEDGAKLRII-----NAKYTIPP 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 578838380 500 PERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd14036  243 NDTQYTVFHDLIRSTLKVNPEERLSITEIVEQLQE 277
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
287-530 5.01e-25

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 104.65  E-value: 5.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK------KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14196   11 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRAsrrgvsREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGS-----VKLTDFGFCAQITpEQSKR 434
Cdd:cd14196   91 SGGELFDFLAQKeSLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIML-LDKNipiphIKLIDFGLAHEIE-DGVEF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRDFLNR 513
Cdd:cd14196  169 KNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANItAVSYDFDEEFFSHTSELAKDFIRK 248
                        250
                 ....*....|....*..
gi 578838380 514 CLEMDVDRRGSAKELLQ 530
Cdd:cd14196  249 LLVKETRKRLTIQEALR 265
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
288-528 5.10e-25

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 104.52  E-value: 5.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILvmrenKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd13991   13 RIGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGL-----TSPRVVPLYGAVREGPWVNIFMDLKEGGSLGQ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSKRSTMV-----GT 440
Cdd:cd13991   88 LIKEQgCLPEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSDGSdAFLCDFGHAECLDPDGLGKSLFTgdyipGT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVD 520
Cdd:cd13991  168 ETHMAPEVVLGKPCDAKVDVWSSCCMMLHMLNGCHPWTQYYSGPLCLKIANEPPPLREIPPSCAPLTAQAIQAGLRKEPV 247

                 ....*...
gi 578838380 521 RRGSAKEL 528
Cdd:cd13991  248 HRASAAEL 255
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
287-530 5.41e-25

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 104.85  E-value: 5.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKELIINeiLVMRENKNPNIVNYLDSY-----LVGDE-----LWVV 356
Cdd:cd14171   12 QKLGTGISGPVRVCVKKSTGERFALKI--LLDRPKARTEVR--LHMMCSGHPNIVQIYDVYansvqFPGESsprarLLIV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVT-ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFcAQItpEQS 432
Cdd:cd14171   88 MELMEGGELFDRISqHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLKPENLLLkdnSEDAPIKLCDFGF-AKV--DQG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMVGTPYWMAPEVV-----------------TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-------YL 488
Cdd:cd14171  165 DLMTPQFTPYYVAPQVLeaqrrhrkersgiptspTPYTYDKSCDMWSLGVIIYIMLCGYPPFYSEHPSRTItkdmkrkIM 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 578838380 489 IATNGTPElQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14171  245 TGSYEFPE-EEWSQISEMAKDIVRKLLCVDPEERMTIEEVLH 285
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
282-530 6.04e-25

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 104.31  E-value: 6.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFE-KIGQGASGTVYTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY---LVGDELWV 355
Cdd:cd14033    1 RFLKFNiEIGRGSFKTVYRGLDTETTVEVAWCELQTRKlsKGERQRFSEEVEMLKGLQHPNIVRFYDSWkstVRGHKCII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 -VMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNILL-GMDGSVKLTDFGFCAqiTPE 430
Cdd:cd14033   81 lVTELMTSGTLKTYLKRfREMKLKLLQRWSRQILKGLHFLHSRcpPILHRDLKCDNIFItGPTGSVKIGDLGLAT--LKR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKaYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP-----ELQNPErlsa 505
Cdd:cd14033  159 ASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCILEMATSEYPYSECQNAAQIYRKVTSGIKpdsfyKVKVPE---- 233
                        250       260
                 ....*....|....*....|....*
gi 578838380 506 vFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14033  234 -LKEIIEGCIRTDKDERFTIQDLLE 257
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
283-530 6.13e-25

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 104.31  E-value: 6.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVA---IKQMNLQQQPK---KELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd14195    7 YEMGEELGSGQFAIVRKCREKGTGKEYAakfIKKRRLSSSRRgvsREEIEREVNILREIQHPNIITLHDIFENKTDVVLI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGSV-----KLTDFGFCAQITPE 430
Cdd:cd14195   87 LELVSGGELFDFLAEKeSLTEEEATQFLKQILDGVHYLHSKRIAHFDLKPENIML-LDKNVpnpriKLIDFGIAHKIEAG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRD 509
Cdd:cd14195  166 NEFKN-IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNIsAVNYDFDEEYFSNTSELAKD 244
                        250       260
                 ....*....|....*....|.
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14195  245 FIRRLLVKDPKKRMTIAQSLE 265
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
279-529 6.19e-25

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 104.42  E-value: 6.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDE 352
Cdd:cd14031    7 PGGRFLKFDiELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQqrFKEEAEMLKGLQHPNIVRFYDSWesvLKGKK 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWV-VMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQI 427
Cdd:cd14031   87 CIVlVTELMTSGTLKTYLKRfKVMKPKVLRSWCRQILKGLQFLHTRTppIIHRDLKCDNIFItGPTGSVKIGDLGLATLM 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKrsTMVGTPYWMAPEVVtRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 507
Cdd:cd14031  167 RTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEV 243
                        250       260
                 ....*....|....*....|..
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14031  244 KEIIEGCIRQNKSERLSIKDLL 265
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
230-477 7.02e-25

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 107.80  E-value: 7.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 230 VPNKEVTPPSAenanSSTLYRNTDRQRKKSKMTDEEILEK---------LRSIVSV---------GDPKKK-YTRFEKIG 290
Cdd:PTZ00267   1 MPNNEVEHGSA----SAELLNQYAKYFPHVLFTSEEAFEKycadldpeaYKKCVDLpegeevpesNNPREHmYVLTTLVG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 291 QGASGTVYTALDIA-TGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 369
Cdd:PTZ00267  77 RNPTTAAFVATRGSdPKEKVVAKFVMLNDERQAAYARSELHCLAACDHFGIVKHFDDFKSDDKLLLIMEYGSGGDLNKQI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 370 TETCMD-----EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS--KRSTMVGTPY 442
Cdd:PTZ00267 157 KQRLKEhlpfqEYEVGLLFYQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGFSKQYSDSVSldVASSFCGTPY 236
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:PTZ00267 237 YLAPELWERKRYSKKADMWSLGVILYELLTLHRPF 271
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
284-526 7.71e-25

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 105.01  E-value: 7.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKI---GQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIIN---------EILVMRENKNPNIVNYLDSYLVGD 351
Cdd:cd05574    1 DHFKKIkllGKGDVGRVYLVRLKGTGKLFAMKVL------DKEEMIKrnkvkrvltEREILATLDHPFLPTLYASFQTST 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTET---CMDEGQI---AAvcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF--GF 423
Cdd:cd05574   75 HLCFVMDYCPGGELFRLLQKQpgkRLPEEVArfyAA---EVLLALEYLHLLGFVYRDLKPENILLHESGHIMLTDFdlSK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 CAQITP--------------------------EQSKRS-TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 476
Cdd:cd05574  152 QSSVTPppvrkslrkgsrrssvksieketfvaEPSARSnSFVGTEEYIAPEVIKGDGHGSAVDWWTLGILLYEMLYGTTP 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 477 YLNENPLRALYLIaTNGTPELQNPERLSAVFRDFLNRCLEMDVDRR-GSAK 526
Cdd:cd05574  232 FKGSNRDETFSNI-LKKELTFPESPPVSSEAKDLIRKLLVKDPSKRlGSKR 281
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
282-482 8.24e-25

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 103.70  E-value: 8.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14662    1 RYELVKDIGSGNFGVARLMRNKETKELVAVKYIE-RGLKIDENVQREIINHRSLRHPNIIRFKEVVLTPTHLAIVMEYAA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgmDGS----VKLTDFGFCAQITPEQSKRST 436
Cdd:cd14662   80 GGELFERICNAGrFSEDEARYFFQQLISGVSYCHSMQICHRDLKLENTLL--DGSpaprLKICDFGYSKSSVLHSQPKST 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 437 mVGTPYWMAPEVVTRKAYGPKV-DIWSLGIMAIEMVEGEPPYlnENP 482
Cdd:cd14662  158 -VGTPAYIAPEVLSRKEYDGKVaDVWSCGVTLYVMLVGAYPF--EDP 201
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
282-530 9.88e-25

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 105.19  E-value: 9.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLD------SYLVGDEL 353
Cdd:cd07850    1 RYQNLKPIGSGAQGIVCAAYDTVTGQNVAIKKLSrpFQNVTHAKRAYRELVLMKLVNHKNIIGLLNvftpqkSLEEFQDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEyLAGGSLTDVVtETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSK 433
Cdd:cd07850   81 YLVME-LMDANLCQVI-QMDLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFM 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG-IMAiEMVE---------------------GEPP-------------YL 478
Cdd:cd07850  158 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGcIMG-EMIRgtvlfpgtdhidqwnkiieqlGTPSdefmsrlqptvrnYV 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578838380 479 NENPLRALYLIA-----TNGTPELQNPERLSA-VFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07850  237 ENRPKYAGYSFEelfpdVLFPPDSEEHNKLKAsQARDLLSKMLVIDPEKRISVDDALQ 294
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
287-534 1.04e-24

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 103.57  E-value: 1.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldIATGQEVAIKQMnlQQQPKKELIINEILVMRENK------NPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14147    9 EVIGIGGFGKVYRG--SWRGELVAVKAA--RQDPDEDISVTAESVRQEARlfamlaHPNIIALKAVCLEEPNLCLVMEYA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ---VIHRDIKSDNILLGMDG--------SVKLTDFGFCAQItp 429
Cdd:cd14147   85 AGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEAlvpVIHRDLKSNNILLLQPIenddmehkTLKITDFGLAREW-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTpELQNPERLSAVFRD 509
Cdd:cd14147  163 HKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKL-TLPIPSTCPEPFAQ 241
                        250       260
                 ....*....|....*....|....*
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd14147  242 LMADCWAQDPHRRPDFASILQQLEA 266
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
288-478 1.18e-24

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 103.89  E-value: 1.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLD-----SYLVGDEL-WVVMEYL 360
Cdd:cd14038    1 RLGTGGFGNVLRWINQETGEQVAIKQCRQELSPKnRERWCLEIQIMKRLNHPNVVAARDvpeglQKLAPNDLpLLAMEYC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVT--ETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSV-KLTDFGFCAQItpEQSK 433
Cdd:cd14038   81 QGGDLRKYLNqfENCcgLREGAILTLLSDISSALRYLHENRIIHRDLKPENIVLqqGEQRLIhKIIDLGYAKEL--DQGS 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 434 RST-MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL 478
Cdd:cd14038  159 LCTsFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFL 204
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
289-528 1.45e-24

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 103.38  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05577    1 LGRGGFGEVCACQVKATGKMYACKKLDKKRIKKKKgetMALNEKIILEKVSSPFIVSLAYAFETKDKLCLVLTLMNGGDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 ---TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItPEQSKRSTMVGTPY 442
Cdd:cd05577   81 kyhIYNVGTRGFSEARAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAVEF-KGGKKIKGRVGTHG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 WMAPEVVTRK-AYGPKVDIWSLGIMAIEMVEGEPPY------LNENPLRALYLiatngTPELQNPERLSAVFRDFLNRCL 515
Cdd:cd05577  160 YMAPEVLQKEvAYDFSVDWFALGCMLYEMIAGRSPFrqrkekVDKEELKRRTL-----EMAVEYPDSFSPEARSLCEGLL 234
                        250
                 ....*....|....*...
gi 578838380 516 EMDVDRR-----GSAKEL 528
Cdd:cd05577  235 QKDPERRlgcrgGSADEV 252
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
284-471 2.47e-24

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 103.03  E-value: 2.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKI---GQGASGTVYTALDIATGQEVAIKQMNLqqqPKKELIINEilVMRENK------NPNIVNYLDSYLVG---- 350
Cdd:cd14048    6 TDFEPIqclGRGGFGVVFEAKNKVDDCNYAVKRIRL---PNNELAREK--VLREVRalakldHPGIVRYFNAWLERppeg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 -----DE--LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQ----ALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 419
Cdd:cd14048   81 wqekmDEvyLYIQMQLCRKENLKDWMNRRCTMESRELFVCLNIFKqiasAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVG 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838380 420 DFGFCA---QITPEQSKRSTM---------VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV 471
Cdd:cd14048  161 DFGLVTamdQGEPEQTVLTPMpayakhtgqVGTRLYMSPEQIHGNQYSEKVDIFALGLILFELI 224
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
282-530 2.70e-24

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 103.34  E-value: 2.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI--INEILVMRENKNPNIVNYLDsyLVGDE------- 352
Cdd:cd07864    8 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPItaIREIKILRQLNHRSVVNLKE--IVTDKqdaldfk 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 -----LWVVMEY----LAGGSLTDVVTetcMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd07864   86 kdkgaFYLVFEYmdhdLMGLLESGLVH---FSEDHIKSFMKQLLEGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 424 cAQITPEQSKR--STMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-TNGTP---- 495
Cdd:cd07864  163 -ARLYNSEESRpyTNKVITLWYRPPELLLgEERYGPAIDVWSCGCILGELFTKKPIFQANQELAQLELISrLCGSPcpav 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 496 ---------------ELQNPERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07864  242 wpdviklpyfntmkpKKQYRRRLREEFSfiptpalDLLDHMLTLDPSKRCTAEQALN 298
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
283-530 3.22e-24

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 101.85  E-value: 3.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQM--NLQQQ----PKKELIINEILVMRE----NKNPNIVNYLDSYLVGDE 352
Cdd:cd14101    2 YTMGNLLGKGGFGTVYAGHRISDGLQVAIKQIsrNRVQQwsklPGVNPVPNEVALLQSvgggPGHRGVIRLLDWFEIPEG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEY-LAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAqiTP 429
Cdd:cd14101   82 FLLVLERpQHCQDLFDYITERgALDESLARRFFKQVVEAVQHCHSKGVVHRDIKDENILVDLrTGDIKLIDFGSGA--TL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY-LNENPLRAlyliatngtpELQNPERLSAVF 507
Cdd:cd14101  160 KDSMYTDFDGTRVYSPPEWILYHQYhALPATVWSLGILLYDMVCGDIPFeRDTDILKA----------KPSFNKRVSNDC 229
                        250       260
                 ....*....|....*....|...
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14101  230 RSLIRSCLAYNPSDRPSLEQILL 252
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
289-534 3.37e-24

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 102.04  E-value: 3.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTAldIATGQEVAIKQMnlQQQPKKELIINEILVMRENK------NPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14146    2 IGVGGFGKVYRA--TWKGQEVAVKAA--RQDPDEDIKATAESVRQEAKlfsmlrHPNIIKLEGVCLEEPNLCLVMEFARG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMDEG-----------------QIAavcreclQALDFLHSNQV---IHRDIKSDNILLG--------MDG 414
Cdd:cd14146   78 GTLNRALAAANAAPGprrarripphilvnwavQIA-------RGMLYLHEEAVvpiLHRDLKSSNILLLekiehddiCNK 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 415 SVKLTDFGFCAQItpEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 494
Cdd:cd14146  151 TLKITDFGLAREW--HRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578838380 495 pELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd14146  229 -TLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILEQLTA 267
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
287-530 3.65e-24

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 3.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYLDSYLVGDELWVVMEYLAGGS- 364
Cdd:cd14174    8 ELLGEGAYAKVQGCVSLQNGKEYAVKIIEKNAGHSRSRVFREVETLYQCQgNKNILELIEFFEDDTRFYLVFEKLRGGSi 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD---GSVKLTDFGF---------CAQI-TPEQ 431
Cdd:cd14174   88 LAHIQKRKHFNEREASRVVRDIASALDFLHTKGIAHRDLKPENILCESPdkvSPVKICDFDLgsgvklnsaCTPItTPEL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 skrSTMVGTPYWMAPEVV---TRKA--YGPKVDIWSLGIMAIEMVEGEPPYLNE----------NPLRA----LYLIATN 492
Cdd:cd14174  168 ---TTPCGSAEYMAPEVVevfTDEAtfYDKRCDLWSLGVILYIMLSGYPPFVGHcgtdcgwdrgEVCRVcqnkLFESIQE 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578838380 493 GTPELQNPE--RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14174  245 GKYEFPDKDwsHISSEAKDLISKLLVRDAKERLSAAQVLQ 284
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
289-534 3.69e-24

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 101.99  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALdiATGQEVAIKQMnlQQQPKKELIINEILVMRENK------NPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14148    2 IGVGGFGKVYKGL--WRGEEVAVKAA--RQDPDEDIAVTAENVRQEARlfwmlqHPNIIALRGVCLNPPHLCLVMEYARG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ---VIHRDIKSDNILLG--------MDGSVKLTDFGFCAQItpEQ 431
Cdd:cd14148   78 GALNRALAGKKVPPHVLVNWAVQIARGMNYLHNEAivpIIHRDLKSSNILILepienddlSGKTLKITDFGLAREW--HK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTpELQNPERLSAVFRDFL 511
Cdd:cd14148  156 TTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKL-TLPIPSTCPEPFARLL 234
                        250       260
                 ....*....|....*....|...
gi 578838380 512 NRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd14148  235 EECWDPDPHGRPDFGSILKRLED 257
STKc_MRCK_alpha cd05623
Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 ...
280-509 3.79e-24

Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270773 [Multi-domain]  Cd Length: 409  Bit Score: 104.71  E-value: 3.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEliinEILVMRENKNPnIVNYlDS-------YLVGDE 352
Cdd:cd05623   71 KEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA----ETACFREERDV-LVNG-DSqwittlhYAFQDD 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 --LWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd05623  145 nnLYLVMDYYVGGDLLTLLSkfEDRLPEDMARFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLM 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQSKRSTM-VGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENpLRALYLIATNGTPELQNPER 502
Cdd:cd05623  225 EDGTVQSSVaVGTPDYISPEILQamedgKGKYGPECDWWSLGVCMYEMLYGETPFYAES-LVETYGKIMNHKERFQFPTQ 303

                 ....*..
gi 578838380 503 LSAVFRD 509
Cdd:cd05623  304 VTDVSEN 310
STKc_DMPK_like cd05597
Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; ...
289-481 4.51e-24

Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is composed of DMPK and DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK). DMPK is expressed in skeletal and cardiac muscles, and in central nervous tissues. The functional role of DMPK is not fully understood. It may play a role in the signal transduction and homeostasis of calcium. The DMPK gene is implicated in myotonic dystrophy 1 (DM1), an inherited multisystemic disorder with symptoms that include muscle hyperexcitability, progressive muscle weakness and wasting, cataract development, testicular atrophy, and cardiac conduction defects. The genetic basis for DM1 is the mutational expansion of a CTG repeat in the 3'-UTR of DMPK. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270748 [Multi-domain]  Cd Length: 331  Bit Score: 103.20  E-value: 4.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEliinEILVMRENKnpnivnylDSYLVGDELWV------------- 355
Cdd:cd05597    9 IGRGAFGEVAVVKLKSTEKVYAMKILNKWEMLKRA----ETACFREER--------DVLVNGDRRWItklhyafqdenyl 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 --VMEYLAGGSL-------TDVVTETcMDEGQIAavcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ 426
Cdd:cd05597   77 ylVMDYYCGGDLltllskfEDRLPEE-MARFYLA----EMVLAIDSIHQLGYVHRDIKPDNVLLDRNGHIRLADFGSCLK 151
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 427 ITPEQSKRSTM-VGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd05597  152 LREDGTVQSSVaVGTPDYISPEILQamedgKGRYGPECDWWSLGVCMYEMLYGETPFYAES 212
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
265-528 4.55e-24

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 102.33  E-value: 4.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 265 EILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDiATGQEVAIKqmnlqqqpKKELIINEILVMRENKNPnivnyl 344
Cdd:cd14200   31 KVLSKKKLLKQYGFPRRPPPRGSKAAQGEQAKPLAPLE-RVYQEIAIL--------KKLDHVNIVKLIEVLDDP------ 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 345 dsylVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC 424
Cdd:cd14200   96 ----AEDNLYMVFDLLRKGPVMEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDDGHVKIADFGVS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 425 AQITPEQSKRSTMVGTPYWMAPEVV--TRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLrALYLIATNGTPELQNPE 501
Cdd:cd14200  172 NQFEGNDALLSSTAGTPAFMAPETLsdSGQSFsGKALDVWAMGVTLYCFVYGKCPFIDEFIL-ALHNKIKNKPVEFPEEP 250
                        250       260
                 ....*....|....*....|....*..
gi 578838380 502 RLSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd14200  251 EISEELKDLILKMLDKNPETRITVPEI 277
STKc_ROCK1 cd05622
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
257-477 5.10e-24

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270772 [Multi-domain]  Cd Length: 405  Bit Score: 104.32  E-value: 5.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 257 KKSKMTDEEILEKLRSIVSVGDPKKKYTRFEK---IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEIL 330
Cdd:cd05622   46 RKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVvkvIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSdsaFFWEERD 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 331 VMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL 410
Cdd:cd05622  126 IMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLL 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 411 GMDGSVKLTDFGFCAQITPEQSKR-STMVGTPYWMAPEVVTRKA----YGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05622  206 DKSGHLKLADFGTCMKMNKEGMVRcDTAVGTPDYISPEVLKSQGgdgyYGRECDWWSVGVFLYEMLVGDTPF 277
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
287-466 5.77e-24

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 101.59  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGD-----ELWVVMEYL 360
Cdd:cd14037    9 KYLAEGGFAHVYLVKTSNGGNRAALKRVYVNDEHDLNVCKREIEIMKRlSGHKNIVGYIDSSANRSgngvyEVLLLMEYC 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFG-FCAQITPEQSKR 434
Cdd:cd14037   89 KGGGVIDLMNQrlqTGLTESEILKIFCDVCEAVAAMHYLKppLIHRDLKVENVLISDSGNYKLCDFGsATTKILPPQTKQ 168
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 578838380 435 STMV--------GTPYWMAPEVV---TRKAYGPKVDIWSLGIM 466
Cdd:cd14037  169 GVTYveedikkyTTLQYRAPEMIdlyRGKPITEKSDIWALGCL 211
STKc_LATS2 cd05626
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs ...
283-523 5.77e-24

Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS2 is an essential mitotic regulator responsible for coordinating accurate cytokinesis completion and governing the stabilization of other mitotic regulators. It is also critical in the maintenance of proper chromosome number, genomic stability, mitotic fidelity, and the integrity of centrosome duplication. Downregulation of LATS2 is associated with poor prognosis in acute lymphoblastic leukemia and breast cancer. The LATS2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173715 [Multi-domain]  Cd Length: 381  Bit Score: 103.94  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05626    3 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHvkaERDILAEADNEWVVKLYYSFQDKDNLYFVMDY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQIAAV-CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA------------- 425
Cdd:cd05626   83 IPGGDMMSLLIRMEVFPEVLARFyIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTgfrwthnskyyqk 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 -------------------------------QITPEQSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV 471
Cdd:cd05626  163 gshirqdsmepsdlwddvsncrcgdrlktleQRATKQHQRclaHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578838380 472 EGEPPYLNENPLRA-LYLIATNGTPELQNPERLSAVFRDFLNR-CLEMDvDRRG 523
Cdd:cd05626  243 VGQPPFLAPTPTETqLKVINWENTLHIPPQVKLSPEAVDLITKlCCSAE-ERLG 295
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
283-529 6.32e-24

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 101.12  E-value: 6.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKElIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14107    4 YEVKEEIGRGTFGFVKRVTHKGNGECCAAKFIPLRSSTRAR-AFQERDILARLSHRRLTCLLDQFETRKTLILILELCSS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL--GMDGSVKLTDFGFCAQITPEQSKRSTMvG 439
Cdd:cd14107   83 EELLDrLFLKGVVTEAEVKLYIQQVLEGIGYLHGMNILHLDIKPDNILMvsPTREDIKICDFGFAQEITPSEHQFSKY-G 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPlRALYLIATNGTPELQNPE--RLSAVFRDFLNRCLEM 517
Cdd:cd14107  162 SPEFVAPEIVHQEPVSAATDIWALGVIAYLSLTCHSPFAGEND-RATLLNVAEGVVSWDTPEitHLSEDAKDFIKRVLQP 240
                        250
                 ....*....|..
gi 578838380 518 DVDRRGSAKELL 529
Cdd:cd14107  241 DPEKRPSASECL 252
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
283-470 7.29e-24

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 101.03  E-value: 7.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQqpkkELIINEILVMRENKNPNIVNYLDSYLVGDE---------- 352
Cdd:cd14047    8 FKEIELIGSGGFGQVFKAKHRIDGKTYAIKRVKLNN----EKAEREVKALAKLDHPNIVRYNGCWDGFDYdpetsssnss 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 ------LWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd14047   84 rsktkcLFIQMEFCEKGTLESWIEKrngEKLDKVLALEIFEQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFGL 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 424 CAQITpEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd14047  164 VTSLK-NDGKRTKSKGTLSYMSPEQISSQDYGKEVDIYALGLILFEL 209
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
283-477 7.59e-24

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 100.70  E-value: 7.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGAsgtvYTALDIATGQE----VAIKQMNLQQQPK---KELIINEILVMRENKNPNIVNYLDSY-LVGDELW 354
Cdd:cd14164    2 YTLGTTIGEGS----FSKVKLATSQKycckVAIKIVDRRRASPdfvQKFLPRELSILRRVNHPNIVQMFECIeVANGRLY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDV--VTETCMDEGQIAAVcrECLQALDFLHSNQVIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQ 431
Cdd:cd14164   78 IVMEAAATDLLQKIqeVHHIPKDLARDMFA--QMVGAVNYLHDMNIVHRDLKCENILLSADDrKIKIADFGFARFVEDYP 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGP-KVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14164  156 ELSTTFCGSRAYTPPEVILGTPYDPkKYDVWSLGVVLYVMVTGTMPF 202
STKc_ROCK2 cd05621
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
264-477 9.68e-24

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2 was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270771 [Multi-domain]  Cd Length: 379  Bit Score: 103.16  E-value: 9.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 264 EEILEKLRSIVSVGDpkkKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNI 340
Cdd:cd05621   38 EKIVNKIRELQMKAE---DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSdsaFFWEERDIMAFANSPWV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 341 VNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
Cdd:cd05621  115 VQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLAD 194
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 421 FGFCAQITPEQSKR-STMVGTPYWMAPEVVTRKA----YGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05621  195 FGTCMKMDETGMVHcDTAVGTPDYISPEVLKSQGgdgyYGRECDWWSVGVFLFEMLVGDTPF 256
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
282-475 1.05e-23

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 102.27  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqQQPKKELII-----NEILVMRENKNPNIVNYLDSYLVGDE-LWV 355
Cdd:cd07856   11 RYSDLQPVGMGAFGLVCSARDQLTGQNVAVKKI---MKPFSTPVLakrtyRELKLLKHLRHENIISLSDIFISPLEdIYF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEyLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQItpEQSKRS 435
Cdd:cd07856   88 VTE-LLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGL-ARI--QDPQMT 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 436 TMVGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd07856  164 GYVSTRYYRAPEImLTWQKYDVEVDIWSAGCIFAEMLEGKP 204
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
278-529 1.10e-23

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 104.57  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE-------------------LIINEILVMRENKNP 338
Cdd:PTZ00283  29 EQAKKYWISRVLGSGATGTVLCAKRVSDGEPFAVKVVDMEGMSEADknraqaevccllncdffsiVKCHEDFAKKDPRNP 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 339 NIVNYLDsylvgdelwVVMEYLAGGSLTDVV-----TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD 413
Cdd:PTZ00283 109 ENVLMIA---------LVLDYANAGDLRQEIksrakTNRTFREHEAGLLFIQVLLAVHHVHSKHMIHRDIKSANILLCSN 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 414 GSVKLTDFGF----CAQITPEQSKrsTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI 489
Cdd:PTZ00283 180 GLVKLGDFGFskmyAATVSDDVGR--TFCGTPYYVAPEIWRRKPYSKKADMFSLGVLLYELLTLKRPFDGENMEEVMHKT 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578838380 490 ATNGTPELqnPERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:PTZ00283 258 LAGRYDPL--PPSISPEMQEIVTALLSSDPKRRPSSSKLL 295
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
279-532 1.14e-23

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 100.50  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYtaLDIATGQEVAIKQMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05039    4 NKKDLKLGELIGKGEFGDVM--LGDYRGQKVAVKCLKDDSTAAQAFL-AEASVMTTLRHPNLVQLLGVVLEGNGLYIVTE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTD--------VVTEtcmdEGQIAaVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfcaqITPE 430
Cdd:cd05039   81 YMAKGSLVDylrsrgraVITR----KDQLG-FALDVCEGMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFG----LAKE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNEnPLRALYLIATNGTpELQNPERLSAVFR 508
Cdd:cd05039  152 ASSNQDGGKLPIkWTAPEALREKKFSTKSDVWSFGILLWEIYSfGRVPYPRI-PLKDVVPHVEKGY-RMEAPEGCPPEVY 229
                        250       260
                 ....*....|....*....|....
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05039  230 KVMKNCWELDPAKRPTFKQLREKL 253
PK_STRAD_beta cd08226
Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain ...
296-529 1.15e-23

Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity.STRAD-beta is also referred to as ALS2CR2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein), since the human gene encoding it is located within the juvenile ALS2 critical region on chromosome 2q33-q34. It is not linked to the development of ALS2. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. The STRAD-beta subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270864 [Multi-domain]  Cd Length: 328  Bit Score: 101.87  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 296 TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS----LTDVV 369
Cdd:cd08226   15 SVYLARHTPTGTLVTVKITNLDNCSEEHLKAlqNEVVLSHFFRHPNIMTHWTVFTEGSWLWVISPFMAYGSarglLKTYF 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 370 TETcMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKR--------STMVgT 440
Cdd:cd08226   95 PEG-MNEALIGNILYGAIKALNYLHQNGCIHRSVKASHILISGDGLVSLSGLsHLYSMVTNGQRSKvvydfpqfSTSV-L 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PyWMAPEVVTRKAYG--PKVDIWSLGIMAIEMVEGEPPYLN-----------ENPLRALYLIA----------------- 490
Cdd:cd08226  173 P-WLSPELLRQDLHGynVKSDIYSVGITACELARGQVPFQDmrrtqmllqklKGPPYSPLDIFpfpelesrmknsqsgmd 251
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578838380 491 --------------TNGTPELQNP--ERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd08226  252 sgigesvatssmtrTMTSERLQTPssKTFSPAFHNLVELCLQQDPEKRPSASSLL 306
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
333-513 1.16e-23

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 102.41  E-value: 1.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 333 RENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Cdd:cd05617   71 QASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMfHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLD 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 412 MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY--LNENPLRAL--Y 487
Cdd:cd05617  151 ADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFdiITDNPDMNTedY 230
                        170       180       190
                 ....*....|....*....|....*....|
gi 578838380 488 LIATNGTPELQNPERLS----AVFRDFLNR 513
Cdd:cd05617  231 LFQVILEKPIRIPRFLSvkasHVLKGFLNK 260
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
281-530 1.73e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 101.48  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQM--NLQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLV--GDELWV 355
Cdd:cd07852    7 RRYEILKKLGKGAYGIVWKAIDKKTGEVVALKKIfdAFRNATDAQRTFREIMFLQElNDHPNIIKLLNVIRAenDKDIYL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAggslTD---VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd07852   87 VFEYME----TDlhaVIRANILEDIHKQYIMYQLLKALKYLHSGGVIHRDLKPSNILLNSDCRVKLADFGLARSLSQLEE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMVGTPY----WM-APEV-VTRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTP------ELQ 498
Cdd:cd07852  163 DDENPVLTDYvatrWYrAPEIlLGSTRYTKGVDMWSVGcILG-EMLLGKPLFPGTSTLNQLEKIiEVIGRPsaedieSIQ 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 499 NPERLSAVFR---------------------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07852  242 SPFAATMLESlppsrpksldelfpkaspdalDLLKKLLVFNPNKRLTAEEALR 294
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
289-477 1.84e-23

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 100.06  E-value: 1.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKELIINeiLVMRENKNPNIVNYLDSY---LVGDE-LWVVMEYLAGGS 364
Cdd:cd14172   12 LGLGVNGKVLECFHRRTGQKCALKL--LYDSPKARREVE--HHWRASGGPHIVHILDVYenmHHGKRcLLIIMECMEGGE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM---DGSVKLTDFGFcAQITPEQSKRSTMV 438
Cdd:cd14172   88 LFSRIQErgdQAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLYTSkekDAVLKLTDFGF-AKETTVQNALQTPC 166
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14172  167 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPF 205
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
288-476 1.90e-23

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 100.65  E-value: 1.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYtaLDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd14158   22 KLGEGGFGVVF--KGYINDKNVAVKKLAamvdISTEDLTKQFEQEIQVMAKCQHENLVELLGYSCDGPQLCLVYTYMPNG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTetCMDEGQIAAVCREC------LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKR--- 434
Cdd:cd14158  100 SLLDRLA--CLNDTPPLSWHMRCkiaqgtANGINYLHENNHIHRDIKSANILLDETFVPKISDFGL-ARASEKFSQTimt 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578838380 435 STMVGTPYWMAPEVVtRKAYGPKVDIWSLGIMAIEMVEGEPP 476
Cdd:cd14158  177 ERIVGTTAYMAPEAL-RGEITPKSDIFSFGVVLLEIITGLPP 217
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
282-529 2.11e-23

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 105.20  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  282 KYTRFEKIGQGASGTVYTALDIATgQEV----AIKQMNLQQQPKKELIInEILVMRENKNPNIVNYLDSYL--VGDELWV 355
Cdd:PTZ00266   14 EYEVIKKIGNGRFGEVFLVKHKRT-QEFfcwkAISYRGLKEREKSQLVI-EVNVMRELKHKNIVRYIDRFLnkANQKLYI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  356 VMEYLAGGSLTDVVtETC------MDEGQIAAVCRECLQALDFLHS-------NQVIHRDIKSDNILLG----------- 411
Cdd:PTZ00266   92 LMEFCDAGDLSRNI-QKCykmfgkIEEHAIVDITRQLLHALAYCHNlkdgpngERVLHRDLKPQNIFLStgirhigkita 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380  412 ----MDGS--VKLTDFGFCAQITPEQSKRSTmVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPL 483
Cdd:PTZ00266  171 qannLNGRpiAKIGDFGLSKNIGIESMAHSC-VGTPYYWSPELLLHetKSYDDKSDMWALGCIIYELCSGKTPFHKANNF 249
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 578838380  484 RALYLIATNGtPELQ---NPERLSAVFRDFLNrcleMDVDRRGSAKELL 529
Cdd:PTZ00266  250 SQLISELKRG-PDLPikgKSKELNILIKNLLN----LSAKERPSALQCL 293
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
286-522 2.12e-23

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 99.71  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTVYTAldiATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLdSYLVGDELWVVMEYLAGG 363
Cdd:cd14150    5 LKRIGTGSFGTVFRG---KWHGDVAVKILKVTEPTPEQLqaFKNEMQVLRKTRHVNILLFM-GFMTRPNFAIITQWCEGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT----PEQSKRSTm 437
Cdd:cd14150   81 SLYRHlhVTETRFDTMQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTrwsgSQQVEQPS- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 vGTPYWMAPEVVTRKAYGP---KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQN-PERLSAVFRDFL 511
Cdd:cd14150  160 -GSILWMAPEVIRMQDTNPysfQSDVYAYGVVLYELMSGTLPYSNINNRDQIIFMVGRGylSPDLSKlSSNCPKAMKRLL 238
                        250
                 ....*....|.
gi 578838380 512 NRCLEMDVDRR 522
Cdd:cd14150  239 IDCLKFKREER 249
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
280-505 2.40e-23

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 101.57  E-value: 2.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDEL---- 353
Cdd:cd07880   14 PDRYRDLKQVGSGAYGTVCSALDRRTGAKVAIKKLYrpFQSELFAKRAYRELRLLKHMKHENVIGLLDVFTPDLSLdrfh 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 --WVVMEYLaGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQitpEQ 431
Cdd:cd07880   94 dfYLVMPFM-GTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---TD 169
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 432 SKRSTMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTPELQNPERLSA 505
Cdd:cd07880  170 SEMTGYVVTRWYRAPEVILNwMHYTQTVDIWSVGCIMAEMLTGKPLFKGHDHLDQLMeIMKVTGTPSKEFVQKLQS 245
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
283-530 2.93e-23

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 99.28  E-value: 2.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14113    9 YSEVAELGRGRFSVVKKCDQRGTKRAVATKFVN-KKLMKRDQVTHELGVLQSLQHPQLVGLLDTFETPTSYILVLEMADQ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFCAQI--TPEQSKrst 436
Cdd:cd14113   88 GRLLDyVVRWGNLTEEKIRFYLREILEALQYLHNCRIAHLDLKPENILVDQSLSkptIKLADFGDAVQLntTYYIHQ--- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAtngTPELQNPER----LSAVFRDFLN 512
Cdd:cd14113  165 LLGSPEFAAPEIILGNPVSLTSDLWSIGVLTYVLLSGVSPFLDESVEETCLNIC---RLDFSFPDDyfkgVSQKAKDFVC 241
                        250
                 ....*....|....*...
gi 578838380 513 RCLEMDVDRRGSAKELLQ 530
Cdd:cd14113  242 FLLQMDPAKRPSAALCLQ 259
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
257-529 3.09e-23

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 100.12  E-value: 3.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 257 KKSKMTDEeiLEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE--LIINEILVMR 333
Cdd:cd14030    2 ERNKQQDE--IEELETKAVG*SPDGRFLKFDiEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSErqRFKEEAGMLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 334 ENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSD 406
Cdd:cd14030   80 GLQHPNIVRFYDSWestVKGKKCIVlVTELMTSGTLKTYLKRfKVMKIKVLRSWCRQILKGLQFLHTRTppIIHRDLKCD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 407 NILL-GMDGSVKLTDFGFCAqiTPEQSKRSTMVGTPYWMAPEVVTRKaYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 485
Cdd:cd14030  160 NIFItGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQ 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 578838380 486 LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14030  237 IYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYAIKDLL 280
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
282-531 7.02e-23

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 98.65  E-value: 7.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDI-ATGQEVAIKQM--NLQQQPKKELIINEILVMRENKN---PNIVNYLDSYLVGDELWV 355
Cdd:cd14052    1 RFANVELIGSGEFSQVYKVSERvPTGKVYAVKKLkpNYAGAKDRLRRLEEVSILRELTLdghDNIVQLIDSWEYHGHLYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDVVTE----TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQ 431
Cdd:cd14052   81 QTELCENGSLDVFLSElgllGRLDEFRVWKILVELSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGM-ATVWPLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRStMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM---VE----GEP------------PYLNENPLRALYLIATN 492
Cdd:cd14052  160 RGIE-REGDREYIAPEILSEHMYDKPADIFSLGLILLEAaanVVlpdnGDAwqklrsgdlsdaPRLSSTDLHSASSPSSN 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 578838380 493 GTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQV 531
Cdd:cd14052  239 PPPDPPNMPILSGSLDRVVRWMLSPEPDRRPTADDVLAT 277
K-ycf53 COG5752
Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 ...
280-532 7.68e-23

Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 porphyrin-binding domain [Signal transduction mechanisms];


Pssm-ID: 444462 [Multi-domain]  Cd Length: 466  Bit Score: 101.62  E-value: 7.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALD--IATGQEVAIKQMNLQQQPKK------ELIINEILVMRE-NKNPNIVNYLDSYLVG 350
Cdd:COG5752   31 KERYRAIKPLGQGGFGRTFLAVDedIPSHPHCVIKQFYFPEQGPSsfqkavELFRQEAVRLDElGKHPQIPELLAYFEQD 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQIT 428
Cdd:COG5752  111 QRLYLVQEFIEGQTLAQeLEKKGVFSESQIWQLLKDLLPVLQFIHSRNVIHRDIKPANIIRRRsDGKLVLIDFGVAKLLT 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 429 PEQ-SKRSTMVGTPYWMAPEVVTRKAYgPKVDIWSLGIMAIEMVEGEPPY-----LNENPLRALYLiatngTPELQNPER 502
Cdd:COG5752  191 ITAlLQTGTIIGTPEYMAPEQLRGKVF-PASDLYSLGVTCIYLLTGVSPFdlfdvSEDRWVWRDFL-----PPGTKVSDR 264
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 503 LSAVfrdfLNRCLEMDV-DRRGSAKELLQVL 532
Cdd:COG5752  265 LGQI----LDKLLQNALkQRYQSATEVLQAL 291
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
284-477 7.98e-23

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 99.30  E-value: 7.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELiinEILVMRENkNPNIVNYLDSYlvGDEL--WVVMEYLA 361
Cdd:cd14092    9 LREEALGDGSFSVCRKCVHKKTGQEFAVKIVSRRLDTSREV---QLLRLCQG-HPNIVKLHEVF--QDELhtYLVMELLR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFcAQITPEQSKRSTM 437
Cdd:cd14092   83 GGELLERIRKKKRfTESEASRIMRQLVSAVSFMHSKGVVHRDLKPENLLFtdeDDDAEIKIVDFGF-ARLKPENQPLKTP 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578838380 438 VGTPYWMAPEVV----TRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14092  162 CFTLPYAAPEVLkqalSTQGYDESCDLWSLGVILYTMLSGQVPF 205
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
283-477 8.52e-23

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 98.56  E-value: 8.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05630    2 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKgeaMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItPEQSKRST 436
Cdd:cd05630   82 MNGGDLKFHIyhmGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKG 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05630  161 RVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF 201
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
289-489 1.09e-22

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 98.14  E-value: 1.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLt 366
Cdd:cd07848    9 VGEGAYGVVLKCRHKETKEIVAIKKFKDSEENEevKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNML- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST-MVGTPYW 443
Cdd:cd07848   88 ELLEEmpNGVPPEKVRSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGSNANYTeYVATRWY 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 444 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI 489
Cdd:cd07848  168 RSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTI 213
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
282-530 1.13e-22

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 98.27  E-value: 1.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQ----PKKELiiNEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd07839    1 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDdegvPSSAL--REICLLKELKHKNIVRLYDVLHSDKKLTLVF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYlaggslTDVVTETCMD--EGQI-AAVCR----ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd07839   79 EY------CDQDLKKYFDscNGDIdPEIVKsfmfQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLN----ENPLRALYLIAtnGTPELQN------ 499
Cdd:cd07839  153 VRCYSAEVVTLWYRPPDVLFgAKLYSTSIDMWSAGCIFAELANAGRPLFPgndvDDQLKRIFRLL--GTPTEESwpgvsk 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 500 -PE------------------RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07839  231 lPDykpypmypattslvnvvpKLNSTGRDLLQNLLVCNPVQRISAEEALQ 280
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
289-497 1.17e-22

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 97.52  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd13978    1 LGSGGFGTVSKARHVSWFGMVAIKCLHSSPNCIEERkaLLKEAEKMERARHSYVLPLLGVCVERRSLGLVMEYMENGSLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTETCMD-----EGQIAavcRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGF--CAQITPEQSKRSTM 437
Cdd:cd13978   81 SLLEREIQDvpwslRFRII---HEIALGMNFLHNMDppLLHHDLKPENILLDNHFHVKISDFGLskLGMKSISANRRRGT 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 438 ---VGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATNGTPEL 497
Cdd:cd13978  158 enlGGTPIYMAPEAFDDFNKKPtsKSDVYSFAIVIWAVLTRKEPFENAiNPLLIMQIVSKGDRPSL 223
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
287-530 1.40e-22

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 98.18  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYLDSYLVGDELWVVMEYLAGGS- 364
Cdd:cd14173    8 EVLGEGAYARVQTCINLITNKEYAVKIIEKRPGHSRSRVFREVEMLYQCQgHRNVLELIEFFEEEDKFYLVFEKMRGGSi 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD---GSVKLTDF---------GFCAQI-TPEQ 431
Cdd:cd14173   88 LSHIHRRRHFNELEASVVVQDIASALDFLHNKGIAHRDLKPENILCEHPnqvSPVKICDFdlgsgiklnSDCSPIsTPEL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 skrSTMVGTPYWMAPEVV-----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE----------NPLRA----LYLIATN 492
Cdd:cd14173  168 ---LTPCGSAEYMAPEVVeafneEASIYDKRCDLWSLGVILYIMLSGYPPFVGRcgsdcgwdrgEACPAcqnmLFESIQE 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 578838380 493 GTPELqnPER----LSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14173  245 GKYEF--PEKdwahISCAAKDLISKLLVRDAKQRLSAAQVLQ 284
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
282-529 1.84e-22

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 98.96  E-value: 1.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNlqqQPKKELI-----INEILVMRENKNPNIVNYLDSYLVG------ 350
Cdd:cd07877   18 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS---RPFQSIIhakrtYRELRLLKHMKHENVIGLLDVFTPArsleef 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMeYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd07877   95 NDVYLVT-HLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKrstMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSA--- 505
Cdd:cd07877  174 MTG---YVATRWYRAPEIMLNwMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRlVGTPGAELLKKISSesa 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 506 -----------------VF-------RDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd07877  251 rnyiqsltqmpkmnfanVFiganplaVDLLEKMLVLDSDKRITAAQAL 298
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
283-513 1.97e-22

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 98.59  E-value: 1.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQM----NLQQQPKKELiiNEILVMRENKNPNIVNYLD------SYLVGDE 352
Cdd:cd07855    7 YEPIETIGSGAYGVVCSAIDTKSGQKVAIKKIpnafDVVTTAKRTL--RELKILRHFKHDNIIAIRDilrpkvPYADFKD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEyLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF--CAQITP 429
Cdd:cd07855   85 VYVVLD-LMESDLHHIIhSDQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMarGLCTSP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKR--STMVGTPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQ-----NP 500
Cdd:cd07855  164 EEHKYfmTEYVATRWYRAPELMlSLPEYTQAIDMWSVGCIFAEMLGRRQLFPGKNYVHQLQLILTVlGTPSQAvinaiGA 243
                        250
                 ....*....|...
gi 578838380 501 ERLSAVFRDFLNR 513
Cdd:cd07855  244 DRVRRYIQNLPNK 256
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
287-534 2.01e-22

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 97.04  E-value: 2.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldIATGQEVAIKQMnlQQQPKKELIINEILVMRENK------NPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14145   12 EIIGIGGFGKVYRA--IWIGDEVAVKAA--RHDPDEDISQTIENVRQEAKlfamlkHPNIIALRGVCLKEPNLCLVMEFA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ---VIHRDIKSDNILLGM--------DGSVKLTDFGFCAQItp 429
Cdd:cd14145   88 RGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHCEAivpVIHRDLKSSNILILEkvengdlsNKILKITDFGLAREW-- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTpELQNPERLSAVFRD 509
Cdd:cd14145  166 HRTTKMSAAGTYAWMAPEVIRSSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKL-SLPIPSTCPEPFAR 244
                        250       260
                 ....*....|....*....|....*
gi 578838380 510 FLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd14145  245 LMEDCWNPDPHSRPPFTNILDQLTA 269
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
288-477 2.26e-22

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 97.41  E-value: 2.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTAldiATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLdSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14149   19 RIGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFqaFRNEVAVLRKTRHVNILLFM-GYMTKDNLAIVTQWCEGSSL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT----PEQSKRSTmvG 439
Cdd:cd14149   95 YKHlhVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSrwsgSQQVEQPT--G 172
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 440 TPYWMAPEVVTRKAYGP---KVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14149  173 SILWMAPEVIRMQDNNPfsfQSDVYSYGIVLYELMTGELPY 213
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
280-533 2.56e-22

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 96.36  E-value: 2.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYtaLDIATGQ-EVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05059    3 PSELTFLKELGSGQFGVVH--LGKWRGKiDVAIKMIK-EGSMSEDDFIEEAKVMMKLSHPKLVQLYGVCTKQRPIFIVTE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd05059   80 YMANGCLLNYLRERrgKFQTEQLLEMCKDVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDDEYTSSV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 mvGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEM-VEGEPPYLNENPLRALYLIATNgtPELQNPERLSAVFRDFLN 512
Cdd:cd05059  160 --GTKFpvkWSPPEVFMYSKFSSKSDVWSFGVLMWEVfSEGKMPYERFSNSEVVEHISQG--YRLYRPHLAPTEVYTIMY 235
                        250       260
                 ....*....|....*....|.
gi 578838380 513 RCLEMDVDRRGSAKELLQVLL 533
Cdd:cd05059  236 SCWHEKPEERPTFKILLSQLT 256
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
289-525 2.81e-22

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 98.07  E-value: 2.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIA---TGQEVAIKQMN----LQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd05614    8 LGTGAYGKVFLVRKVSghdANKLYAMKVLRkaalVQKAKTVEHTRTERNVLEHvRQSPFLVTLHYAFQTDAKLHLILDYV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-TMV 438
Cdd:cd05614   88 SGGELfTHLYQRDHFSEDEVRFYSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSKEFLTEEKERTySFC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNE---NPLRALYLIATNGTPELqnPERLSAVFRDFLNRC 514
Cdd:cd05614  168 GTIEYMAPEIIRGKSgHGKAVDWWSLGILMFELLTGASPFTLEgekNTQSEVSRRILKCDPPF--PSFIGPVARDLLQKL 245
                        250
                 ....*....|..
gi 578838380 515 LEMDVDRR-GSA 525
Cdd:cd05614  246 LCKDPKKRlGAG 257
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
274-511 3.59e-22

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 98.18  E-value: 3.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 274 VSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
Cdd:cd07876   10 VQVADSTftvlKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSrpFQNQTHAKRAYRELVLLKCVNHKNIISLLNVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 348 LVG------DELWVVMEyLAGGSLTDVVtETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd07876   90 TPQksleefQDVYLVME-LMDANLCQVI-HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFcAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNP 500
Cdd:cd07876  168 GL-ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWnKVIEQLGTPSAEFM 246
                        250
                 ....*....|.
gi 578838380 501 ERLSAVFRDFL 511
Cdd:cd07876  247 NRLQPTVRNYV 257
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
281-530 3.61e-22

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 98.05  E-value: 3.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLD---SYLVGDEL-- 353
Cdd:cd07879   15 ERYTSLKQVGSGAYGSVCSAIDKRTGEKVAIKKLSrpFQSEIFAKRAYRELTLLKHMQHENVIGLLDvftSAVSGDEFqd 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 -WVVMEYLaggsLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd07879   95 fYLVMPYM----QTDLqkIMGHPLSEDKVQYLVYQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHADAE 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKrstMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERL----- 503
Cdd:cd07879  171 MTG---YVVTRWYRAPEVILNwMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIlKVTGVPGPEFVQKLedkaa 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 504 ----------------------SAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07879  248 ksyikslpkyprkdfstlfpkaSPQAVDLLEKMLELDVDKRLTATEALE 296
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
289-532 4.14e-22

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 95.85  E-value: 4.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIiNEILVMRE-NKNPNIVNYLDSYLVGDELWV-VMEYLAGGSLT 366
Cdd:cd13987    1 LGEGTYGKVLLAVHKGSGTKMALKFVPKPSTKLKDFL-REYNISLElSVHPHIIKTYDVAFETEDYYVfAQEYAPYGDLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVT-ETCMDEgqiaAVCRECLQ----ALDFLHSNQVIHRDIKSDNILLgMDGS---VKLTDFGFC-AQITPEQSKRSTm 437
Cdd:cd13987   80 SIIPpQVGLPE----ERVKRCAAqlasALDFMHSKNLVHRDIKPENVLL-FDKDcrrVKLCDFGLTrRVGSTVKRVSGT- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 vgTPYwMAPEVV-TRKAYG----PKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-------ATNGTPELQNP--ERL 503
Cdd:cd13987  154 --IPY-TAPEVCeAKKNEGfvvdPSIDVWAFGVLLFCCLTGNFPWEKADSDDQFYEEfvrwqkrKNTAVPSQWRRftPKA 230
                        250       260
                 ....*....|....*....|....*....
gi 578838380 504 SAVFRdflnRCLEMDVDRRGSAKELLQVL 532
Cdd:cd13987  231 LRMFK----KLLAPEPERRCSIKEVFKYL 255
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
283-476 4.53e-22

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 97.43  E-value: 4.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd06649    7 FERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAiRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC-MDEGQIAAVCRECLQALDFL-HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpeQSKRSTMVG 439
Cdd:cd06649   87 GGSLDQVLKEAKrIPEEILGKVSIAVLRGLAYLrEKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVG 164
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 476
Cdd:cd06649  165 TRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYP 201
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
289-532 5.34e-22

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 95.66  E-value: 5.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Cdd:cd14156    1 IGSGFFSKVYKVTHGATGKVMVVKIY--KNDVDQHKIVREISLLQKLSHPNIVRYLGICVKDEKLHPILEYVSGGCLEEL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 VT--ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVK---LTDFGFCAQI----TPEQSKRSTMVG 439
Cdd:cd14156   79 LAreELPLSWREKVELACDISRGMVYLHSKNIYHRDLNSKNCLIRVTPRGReavVTDFGLAREVgempANDPERKLSLVG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN--PERlsavFRDFLNRCLEM 517
Cdd:cd14156  159 SAFWMAPEMLRGEPYDRKVDVFSFGIVLCEILARIPADPEVLPRTGDFGLDVQAFKEMVPgcPEP----FLDLAASCCRM 234
                        250
                 ....*....|....*
gi 578838380 518 DVDRRGSAKELLQVL 532
Cdd:cd14156  235 DAFKRPSFAELLDEL 249
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
279-534 5.76e-22

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 95.87  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVY--TALDIATGQ---EVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd05032    4 PREKITLIRELGQGSFGMVYegLAKGVVKGEpetRVAIKTVNENASMRERIeFLNEASVMKEFNCHHVVRLLGVVSTGQP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETCMDE-----------GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd05032   84 TLVVMELMAKGDLKSYLRSRRPEAennpglgpptlQKFIQMAAEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKRSTMVGT-PY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYL---NENPLRalYLIATNgtp 495
Cdd:cd05032  164 GMTRDIYETDYYRKGGKGLlPVrWMAPESLKDGVFTTKSDVWSFGVVLWEMATlAEQPYQglsNEEVLK--FVIDGG--- 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 578838380 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd05032  239 HLDLPENCPDKLLELMRMCWQYNPKMRPTFLEIVSSLKD 277
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
69-141 5.85e-22

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 89.29  E-value: 5.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380   69 EISLPSDFEHTIHVGFDAVTGEFTpdlygsqmcpgklpeGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY 141
Cdd:pfam00786   1 MISAPTNFKHTVHVGFDPDTGFFT---------------GLPPEWAKLLDSSGITEDEQKENPKAVLDVLKFY 58
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
283-481 6.08e-22

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 95.35  E-value: 6.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKElIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14108    4 YDIHKEIGRGAFSYLRRVKEKSSDLSFAAKFIPVRAKKKTS-ARRELALLAELDHKSIVRFHDAFEKRRVVIIVTELCHE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTMvGT 440
Cdd:cd14108   83 ELLERITKRPTVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKPENLLMADQKTdqVRICDFGNAQELTPNEPQYCKY-GT 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 441 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd14108  162 PEFVAPEIVNQSPVSKVTDIWPVGVIAYLCLTGISPFVGEN 202
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
280-477 6.27e-22

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 96.58  E-value: 6.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd05632    1 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKgesMALNEKQILEKVNSQFVVNLAYAYETKDALCLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItPEQSK 433
Cdd:cd05632   81 LTIMNGGDLKFHIYNMGnpgFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGES 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578838380 434 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05632  160 IRGRVGTVGYMAPEVLNNQRYTLSPDYWGLGCLIYEMIEGQSPF 203
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
282-506 9.85e-22

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 96.39  E-value: 9.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD-----ELW 354
Cdd:cd07859    1 RYKIQEVIGKGSYGVVCSAIDTHTGEKVAIKKINdvFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSrrefkDIY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEyLAGGSLTDVVT---ETCMDEGQIaaVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQI---- 427
Cdd:cd07859   81 VVFE-LMESDLHQVIKandDLTPEHHQF--FLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGL-ARVafnd 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTN--GTPelqNPERL 503
Cdd:cd07859  157 TPTAIFWTDYVATRWYRAPELCGSffSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLI-TDllGTP---SPETI 232

                 ...
gi 578838380 504 SAV 506
Cdd:cd07859  233 SRV 235
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
281-530 1.05e-21

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 96.22  E-value: 1.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN-LQQQPKKELIINEILVMRENKNPNIVNYLD-----SYLVGDELW 354
Cdd:cd07849    5 PRYQNLSYIGEGAYGMVCSAVHKPTGQKVAIKKISpFEHQTYCLRTLREIKILLRFKHENIIGILDiqrppTFESFKDVY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAggslTD---VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQ 431
Cdd:cd07849   85 IVQELME----TDlykLIKTQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGL-ARIADPE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTM----VGTPYWMAPEV-VTRKAYGPKVDIWSLG-IMAiEMVEGEPPYLNENPLRALYLI-ATNGTP---ELQNPE 501
Cdd:cd07849  160 HDHTGFlteyVATRWYRAPEImLNSKGYTKAIDIWSVGcILA-EMLSNRPLFPGKDYLHQLNLIlGILGTPsqeDLNCII 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 502 RLSA-----------------VFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07849  239 SLKArnyikslpfkpkvpwnkLFPnadpkalDLLDKMLTFNPHKRITVEEALA 291
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
289-522 1.48e-21

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 95.07  E-value: 1.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIA---TGQEVAIKQMN----LQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd05613    8 LGTGAYGKVFLVRKVSghdAGKLYAMKVLKkatiVQKAKTAEHTRTERQVLEHiRQSPFLVTLHYAFQTDTKLHLILDYI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSL-TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-TMV 438
Cdd:cd05613   88 NGGELfTHLSQRERFTENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEFLLDENERAySFC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVT--RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQNPERLSAVFRDFLNRCL 515
Cdd:cd05613  168 GTIEYMAPEIVRggDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRiLKSEPPYPQEMSALAKDIIQRLL 247

                 ....*..
gi 578838380 516 EMDVDRR 522
Cdd:cd05613  248 MKDPKKR 254
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
282-530 1.67e-21

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 94.54  E-value: 1.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14104    1 KYMIAEELGRGQFGIVHRCVETSSKKTYMAKFVKVKGA-DQVLVKKEISILNIARHRNILRLHESFESHEELVMIFEFIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd14104   80 GVDIFERITTARfeLNEREIVSYVRQVCEALEFLHSKNIGHFDIRPENIIYCTRRGsyIKIIEFGQSRQLKPGDKFRLQY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VgTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLE 516
Cdd:cd14104  160 T-SAEFYAPEVHQHESVSTATDMWSLGCLVYVLLSGINPFEAETNQQTIENIRNaEYAFDDEAFKNISIEALDFVDRLLV 238
                        250
                 ....*....|....
gi 578838380 517 MDVDRRGSAKELLQ 530
Cdd:cd14104  239 KERKSRMTAQEALN 252
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
279-528 1.71e-21

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 94.76  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTV----YTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLD-SYLVGD- 351
Cdd:cd05038    2 EERHLKFIKQLGEGHFGSVelcrYDPLGDNTGEQVAVKSLQPSGEEQhMSDFKREIEILRTLDHEYIVKYKGvCESPGRr 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITP 429
Cdd:cd05038   82 SLRLIMEYLPSGSLRDYLQRHrdQIDLKRLLLFASQICKGMEYLGSQRYIHRDLAARNILVESEDLVKISDFGL-AKVLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EqSKRSTMVGTP-----YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPpylNENPLRA-LYLIATNGTPE------ 496
Cdd:cd05038  161 E-DKEYYYVKEPgespiFWYAPECLRESRFSSASDVWSFGVTLYELFTyGDP---SQSPPALfLRMIGIAQGQMivtrll 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 497 --LQNPERLSA-------VFrDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd05038  237 elLKSGERLPRppscpdeVY-DLMKECWEYEPQDRPSFSDL 276
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
283-529 1.76e-21

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 93.91  E-value: 1.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQmnlqqqpKKELIINEilVMRENK------------NPNIVNYLDSYLVG 350
Cdd:cd14050    3 FTILSKLGEGSFGEVFKVRSREDGKLYAVKR-------SRSRFRGE--KDRKRKleeverheklgeHPNCVRFIKAWEEK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEyLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP 429
Cdd:cd14050   74 GILYIQTE-LCDTSLQQYCEEThSLPESEVWNILLDLLKGLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGLVVELDK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMvGTPYWMAPEVVtRKAYGPKVDIWSLGIMA------IEMVEGEPPYlneNPLRALYLIA--TNGtpelqnpe 501
Cdd:cd14050  153 EDIHDAQE-GDPRYMAPELL-QGSFTKAADIFSLGITIlelacnLELPSGGDGW---HQLRQGYLPEefTAG-------- 219
                        250       260
                 ....*....|....*....|....*...
gi 578838380 502 rLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14050  220 -LSPELRSIIKLMMDPDPERRPTAEDLL 246
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
281-482 2.45e-21

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 93.83  E-value: 2.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKqMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14110    3 KTYAFQTEINRGRFSVVRQCEEKRSGQMLAAK-IIPYKPEDKQLVLREYQVLRRLSHPRIAQLHSAYLSPRHLVLIEELC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ----SKRS 435
Cdd:cd14110   82 SGPELLYNLAErNSYSEAEVTDYLWQILSAVDYLHSRRILHLDLRSENMIITEKNLLKIVDLGNAQPFNQGKvlmtDKKG 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 436 TMVGTpywMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:cd14110  162 DYVET---MAPELLEGQGAGPQTDIWAIGVTAFIMLSADYPVSSDLN 205
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
283-477 2.77e-21

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 94.26  E-value: 2.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd07870    2 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMKTEEGVPFTaIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 ggslTDVVTETCMDEG-----QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-AQITPEQSKRS 435
Cdd:cd07870   82 ----TDLAQYMIQHPGglhpyNVRLFMFQLLRGLAYIHGQHILHRDLKPQNLLISYLGELKLADFGLArAKSIPSQTYSS 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 578838380 436 TMVgTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd07870  158 EVV-TLWYRPPDVLLGATdYSSALDIWGAGCIFIEMLQGQPAF 199
STKc_NDR2 cd05627
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze ...
289-482 3.56e-21

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR2 (also called STK38-like) plays a role in proper centrosome duplication. In addition, it is involved in regulating neuronal growth and differentiation, as well as in facilitating neurite outgrowth. NDR2 is also implicated in fear conditioning as it contributes to the coupling of neuronal morphological changes with fear-memory consolidation. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270776 [Multi-domain]  Cd Length: 366  Bit Score: 95.51  E-value: 3.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05627   10 IGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHiraERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ------------- 431
Cdd:cd05627   90 mTLLMKKDTLSEEATQFYIAETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHrtefyrnlthnpp 169
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 432 ---------SKRS-------------TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:cd05627  170 sdfsfqnmnSKRKaetwkknrrqlaySTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 242
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
289-490 4.70e-21

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 94.56  E-value: 4.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI---INE--ILVMRENKN-PNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd05586    1 IGKGTFGQVYQVRKKDTRRIYAMKVLSKKVIVAKKEVahtIGErnILVRTALDEsPFIVGLKFSFQTPTDLYLVTDYMSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441
Cdd:cd05586   81 GELFwHLQKEGRFSEDRAKFYIAELVLALEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKADLTDNKTTNTFCGTT 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 490
Cdd:cd05586  161 EYLAPEVlLDEKGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYRNIA 210
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
282-495 5.53e-21

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 93.34  E-value: 5.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:PLN00009   3 QYEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEQEDEgvPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LaggsltDVVTETCMDEGQ--------IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQITPE 430
Cdd:PLN00009  83 L------DLDLKKHMDSSPdfaknprlIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRrTNALKLADFGLARAFGIP 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 431 QSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP 495
Cdd:PLN00009 157 VRTFTHEVVTLWYRAPEILLgSRHYSTPVDIWSVGCIFAEMVNQKPLFPGDSEIDELFKIfRILGTP 223
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
277-530 5.89e-21

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 93.76  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 277 GDPKKkYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqQP-KKELIINEILVMRE-NKNPNIVNYLDsyLVGDELW 354
Cdd:cd14132   15 GSQDD-YEIIRKIGRGKYSEVFEGINIGNNEKVVIKVL----KPvKKKKIKREIKILQNlRGGPNIVKLLD--VVKDPQS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 ----VVMEYLAG-------GSLTDvvtetcMDegqIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG-SVKLTDFG 422
Cdd:cd14132   88 ktpsLIFEYVNNtdfktlyPTLTD------YD---IRYYMYELLKALDYCHSKGIMHRDVKPHNIMIDHEKrKLRLIDWG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 423 FCAQITPEQsKRSTMVGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATN-GTPELQN 499
Cdd:cd14132  159 LAEFYHPGQ-EYNVRVASRYYKGPELlVDYQYYDYSLDMWSLGCMLASMIFRKEPFFHgHDNYDQLVKIAKVlGTDDLYA 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838380 500 ---------PERLSAVFR------------------------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14132  238 yldkygielPPRLNDILGrhskkpwerfvnsenqhlvtpealDLLDKLLRYDHQERITAKEAMQ 301
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
281-532 6.26e-21

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 92.35  E-value: 6.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVytALDIATGQEVAIKqmNLQQQPKKELIINEILVMRENKNPNIVNYLdSYLVGDE--LWVVME 358
Cdd:cd05082    6 KELKLLQTIGKGEFGDV--MLGDYRGNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLL-GVIVEEKggLYIVTE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
Cdd:cd05082   81 YMAKGSLVDYLRsrgRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGtpyWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYlNENPLRALYLIATNGTpELQNPERLSAVFRDFLNRC 514
Cdd:cd05082  161 LPVK---WTAPEALREKKFSTKSDVWSFGILLWEIYSfGRVPY-PRIPLKDVVPRVEKGY-KMDAPDGCPPAVYDVMKNC 235
                        250
                 ....*....|....*...
gi 578838380 515 LEMDVDRRGSAKELLQVL 532
Cdd:cd05082  236 WHLDAAMRPSFLQLREQL 253
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
289-477 7.87e-21

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 93.32  E-value: 7.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMN-LQQQPKKELIINEILVMRENKNPNIVNYL--DSYLVGDELWVVMEYLAGGSL 365
Cdd:cd13988    1 LGQGATANVFRGRHKKTGDLYAVKVFNnLSFMRPLDVQMREFEVLKKLNHKNIVKLFaiEEELTTRHKVLVMELCPCGSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL--LGMDGSV--KLTDFGFCAQITPEQSKRStM 437
Cdd:cd13988   81 YTVLEEPSnaygLPESEFLIVLRDVVAGMNHLRENGIVHRDIKPGNIMrvIGEDGQSvyKLTDFGAARELEDDEQFVS-L 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 438 VGTPYWMAPEVVTR--------KAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd13988  160 YGTEEYLHPDMYERavlrkdhqKKYGATVDLWSIGVTFYHAATGSLPF 207
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
282-472 9.65e-21

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 93.39  E-value: 9.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMR--ENKNPNIVNY---------------- 343
Cdd:cd13977    1 KYSLIREVGRGSYGVVYEAVVRRTGARVAVKKIRCNAPENVELALREFWALSsiQRQHPNVIQLeecvlqrdglaqrmsh 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 344 ----LDSYLVGDE----------------LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDI 403
Cdd:cd13977   81 gsskSDLYLLLVEtslkgercfdprsacyLWFVMEFCDGGDMNEYLLSRRPDRQTNTSFMLQLSSALAFLHRNQIVHRDL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 404 KSDNILLGM---DGSVKLTDFGF---CAQITPE--------QSKRSTMVGTPYWMAPEvVTRKAYGPKVDIWSLGIMAIE 469
Cdd:cd13977  161 KPDNILISHkrgEPILKVADFGLskvCSGSGLNpeepanvnKHFLSSACGSDFYMAPE-VWEGHYTAKADIFALGIIIWA 239

                 ...
gi 578838380 470 MVE 472
Cdd:cd13977  240 MVE 242
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
286-522 1.01e-20

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 92.64  E-value: 1.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd05608    6 FRVLGKGGFGEVSACQMRATGKLYACKKLNKKRLKKRkgyEGAMVEKRILAKVHSRFIVSLAYAFQTKTDLCLVMTIMNG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLT----DVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05608   86 GDLRyhiyNVDEENpGFQEPRACFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAVELKDGQTKTKGY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL--------NENPLRALYLIATngtpelqNPERLSAVFRD 509
Cdd:cd05608  166 AGTPGFMAPELLLGEEYDYSVDYFTLGVTLYEMIAARGPFRargekvenKELKQRILNDSVT-------YSEKFSPASKS 238
                        250
                 ....*....|...
gi 578838380 510 FLNRCLEMDVDRR 522
Cdd:cd05608  239 ICEALLAKDPEKR 251
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
282-529 1.13e-20

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 92.06  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFE-KIGQGASGTVYTALDIATGQEVAI------KQMNLQQQPKKEliinEILVMRENKNPNIVNYLDSYLVGDE-- 352
Cdd:cd14032    1 RFLKFDiELGRGSFKTVYKGLDTETWVEVAWcelqdrKLTKVERQRFKE----EAEMLKGLQHPNIVRFYDFWESCAKgk 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 --LWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAq 426
Cdd:cd14032   77 rcIVLVTELMTSGTLKTYLKRfKVMKPKVLRSWCRQILKGLLFLHTRTppIIHRDLKCDNIFItGPTGSVKIGDLGLAT- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 427 iTPEQSKRSTMVGTPYWMAPEVVtRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP-----ELQNPE 501
Cdd:cd14032  156 -LKRASFAKSVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKpasfeKVTDPE 233
                        250       260
                 ....*....|....*....|....*...
gi 578838380 502 rlsavFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd14032  234 -----IKEIIGECICKNKEERYEIKDLL 256
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
338-513 1.22e-20

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 93.56  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 338 PNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV 416
Cdd:cd05618   81 PFLVGLHSCFQTESRLFFVIEYVNGGDLMfHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 417 KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY----LNENPLRAL--YLIA 490
Cdd:cd05618  161 KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFdivgSSDNPDQNTedYLFQ 240
                        170       180
                 ....*....|....*....|....*..
gi 578838380 491 TNGTPELQNPERLS----AVFRDFLNR 513
Cdd:cd05618  241 VILEKQIRIPRSLSvkaaSVLKSFLNK 267
PK_STRAD_alpha cd08227
Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain ...
289-529 1.38e-20

Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha, stabilized through ATP and MO25, may be needed to activate LKB1. A mutation which results in a truncation of a C-terminal part of the human STRAD-alpha pseudokinase domain and disrupts its association with LKB1, leads to PMSE (polyhydramnios, megalencephaly, symptomatic epilepsy) syndrome. Several splice variants of STRAD-alpha exist which exhibit different effects on the localization and activation of LKB1. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. The STRAD alpha subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173767 [Multi-domain]  Cd Length: 327  Bit Score: 93.08  E-value: 1.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd08227    6 IGRGFEDlmTVNLARYKPTGEYVTVRRINLEACTNEmvTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETCMD---EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLT---------DFGFCAQITPEQS 432
Cdd:cd08227   86 AKDLICTHFMDgmsELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSglrsnlsmiNHGQRLRVVHDFP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMVgTPyWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPPYlNENPLRALYLIATNGT---------------- 494
Cdd:cd08227  166 KYSVKV-LP-WLSPEVLQQnlQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGTvpclldtttipaeelt 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 495 --------------------PELQNPE--------RLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd08227  243 mkpsrsgansglgesttvstPRPSNGEssshpynrTFSPHFHHFVEQCLQRNPDARPSASTLL 305
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
283-475 1.44e-20

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 92.38  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpkKELI----INEILVMRENKNPNIVNYLD-SYLVGDE----- 352
Cdd:cd07866   10 YEILGKLGEGTFGEVYKARQIKTGRVVALKKILMHNE--KDGFpitaLREIKILKKLKHPNVVPLIDmAVERPDKskrkr 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 --LWVVMEY----LAGGSLTDVVTETcmdEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQ 426
Cdd:cd07866   88 gsVYMVTPYmdhdLSGLLENPSVKLT---ESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLARP 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 427 IT--PEQSKR---------STMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd07866  165 YDgpPPNPKGgggggtrkyTNLVVTRWYRPPELLLgERRYTTAVDIWGIGCVFAEMFTRRP 225
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
276-474 1.56e-20

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 93.91  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 276 VGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQmnlqqqPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV 355
Cdd:PHA03212  87 AGIEKAGFSILETFTPGAEGFAFACIDNKTCEHVVIKA------GQRGGTATEAHILRAINHPSIIQLKGTFTYNKFTCL 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VME--------YLAGGSLTDVvtetCmdegQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG-FCAQ 426
Cdd:PHA03212 161 ILPryktdlycYLAAKRNIAI----C----DILAIERSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGaACFP 232
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 427 ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 474
Cdd:PHA03212 233 VDINANKYYGWAGTIATNAPELLARDPYGPAVDIWSAGIVLFEMATCH 280
STKc_LATS1 cd05625
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the ...
283-523 1.60e-20

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumor suppressor and is implicated in cell cycle regulation. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes. The LATS1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270775 [Multi-domain]  Cd Length: 382  Bit Score: 93.57  E-value: 1.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqQPKKELIINEIL-------VMRENKNPNIVNYLDSYLVGDELWV 355
Cdd:cd05625    3 FVKIKTLGIGAFGEVCLARKVDTKALYATKTL----RKKDVLLRNQVAhvkaerdILAEADNEWVVRLYYSFQDKDNLYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDVVTETCMDEGQIAAV-CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA--------- 425
Cdd:cd05625   79 VMDYIPGGDMMSLLIRMGVFPEDLARFyIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTgfrwthdsk 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 -----------------------------QITP------EQSKR---STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
Cdd:cd05625  159 yyqsgdhlrqdsmdfsnewgdpencrcgdRLKPlerraaRQHQRclaHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVIL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 468 IEMVEGEPPYLNENPLRA-LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRG 523
Cdd:cd05625  239 FEMLVGQPPFLAQTPLETqMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLG 295
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
283-477 1.64e-20

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 91.98  E-value: 1.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05631    2 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKgeaMALNEKRILEKVNSRFVVSLAYAYETKDALCLVLTI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItPEQSKRST 436
Cdd:cd05631   82 MNGGDLKFHIynmGNPGFDEQRAIFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQI-PEGETVRG 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05631  161 RVGTVGYMAPEVINNEKYTFSPDWWGLGCLIYEMIQGQSPF 201
STKc_NDR1 cd05628
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze ...
289-482 1.96e-20

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR1 (also called STK38) plays a role in proper centrosome duplication. It is highly expressed in thymus, muscle, lung and spleen. It is not an essential protein because mice deficient of NDR1 remain viable and fertile. However, these mice develop T-cell lymphomas and appear to be hypersenstive to carcinogenic treatment. NDR1 appears to also act as a tumor suppressor. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270777 [Multi-domain]  Cd Length: 376  Bit Score: 93.18  E-value: 1.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05628    9 IGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQvghIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 -TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ------------- 431
Cdd:cd05628   89 mTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHrtefyrnlnhslp 168
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 432 ---------SKRS-------------TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
Cdd:cd05628  169 sdftfqnmnSKRKaetwkrnrrqlafSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 241
STKc_TTBK cd14017
Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the ...
282-477 2.08e-20

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270919 [Multi-domain]  Cd Length: 263  Bit Score: 91.17  E-value: 2.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpkKELIINEILVMRENKN-PNIVNYLDSYLVGDELWVVMEyL 360
Cdd:cd14017    1 RWKVVKKIGGGGFGEIYKVRDVVDGEEVAMKVESKSQP--KQVLKMEVAVLKKLQGkPHFCRLIGCGRTERYNYIVMT-L 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTET---CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS----VKLTDFGFCAQITP---- 429
Cdd:cd14017   78 LGPNLAELRRSQprgKFSVSTTLRLGIQILKAIEDIHEVGFLHRDVKPSNFAIGRGPSdertVYILDFGLARQYTNkdge 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 430 -EQSKRST--MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14017  158 vERPPRNAagFRGTVRYASVNAHRNKEQGRRDDLWSWFYMLIEFVTGQLPW 208
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
289-529 3.49e-20

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 91.25  E-value: 3.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQmnLQQQPKKELIINeiLVMRENKNPNIVNYLDSY--LVGDE--LWVVMEYLAGGS 364
Cdd:cd14170   10 LGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVE--LHWRASQCPHIVRIVDVYenLYAGRkcLLIVMECLDGGE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM---DGSVKLTDFGFCAQITPEQSkRSTMV 438
Cdd:cd14170   86 LFSRIQDrgdQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSkrpNAILKLTDFGFAKETTSHNS-LTTPC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR---ALYLIATNGTPELQNPE--RLSAVFRDFLNR 513
Cdd:cd14170  165 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAispGMKTRIRMGQYEFPNPEwsEVSEEVKMLIRN 244
                        250
                 ....*....|....*.
gi 578838380 514 CLEMDVDRRGSAKELL 529
Cdd:cd14170  245 LLKTEPTQRMTITEFM 260
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
287-471 3.50e-20

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 90.85  E-value: 3.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALdiATGQEVAIKQMNLQQ----QPKKELIINEILvmrenKNPNIVNYLDSYLVG----DELWVVME 358
Cdd:cd14053    1 EIKARGRFGAVWKAQ--YLNRLVAVKIFPLQEkqswLTEREIYSLPGM-----KHENILQFIGAEKHGesleAEYWLITE 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN----------QVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd14053   74 FHERGSLCDYLKGNVISWNELCKIAESMARGLAYLHEDipatngghkpSIAHRDFKSKNVLLKSDLTACIADFGLALKFE 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 429 PEQSKRST--MVGTPYWMAPEVV------TRKAYgPKVDIWSLGIMAIEMV 471
Cdd:cd14053  154 PGKSCGDThgQVGTRRYMAPEVLegainfTRDAF-LRIDMYAMGLVLWELL 203
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
282-529 4.18e-20

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 91.24  E-value: 4.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKI---GQGASGTVYTALDIATGQE----VAIKQMNLQQQPK--KElIINEILVMRENKNPNIVNYLDSYLVgDE 352
Cdd:cd05108    5 KETEFKKIkvlGSGAFGTVYKGLWIPEGEKvkipVAIKELREATSPKanKE-ILDEAYVMASVDNPHVCRLLGICLT-ST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETCMDEGQ--IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd05108   83 VQLITQLMPFGCLLDYVREHKDNIGSqyLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYlNENPLRALYLIATNGTPELQNPERLSAVF 507
Cdd:cd05108  163 EKEYHAEGGkVPIkWMALESILHRIYTHQSDVWSYGVTVWElMTFGSKPY-DGIPASEISSILEKGERLPQPPICTIDVY 241
                        250       260
                 ....*....|....*....|..
gi 578838380 508 RdFLNRCLEMDVDRRGSAKELL 529
Cdd:cd05108  242 M-IMVKCWMIDADSRPKFRELI 262
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
281-470 4.40e-20

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 90.64  E-value: 4.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYL--VGDELWVV 356
Cdd:cd14049    6 NEFEEIARLGKGGYGKVYKVRNKLDGQYYAIKKILIKKVTKRDCmkVLREVKVLAGLQHPNIVGYHTAWMehVQLMLYIQ 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEyLAGGSLTDVVTE---------------TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDGSVKLTD 420
Cdd:cd14049   86 MQ-LCELSLWDWIVErnkrpceeefksapyTPVDVDVTTKILQQLLEGVTYIHSMGIVHRDLKPRNIFLhGSDIHVRIGD 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 421 FGF-CAQITPEQSKRSTM-----------VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd14049  165 FGLaCPDILQDGNDSTTMsrlnglthtsgVGTCLYAAPEQLEGSHYDFKSDMYSIGVILLEL 226
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
284-532 4.42e-20

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 90.01  E-value: 4.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKIGQGASGTVYTALDIATgQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd05112    7 TFVQEIGSGQFGLVHLGYWLNK-DKVAIKTIR-EGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTEtcmDEGQIAA-----VCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTmv 438
Cdd:cd05112   85 CLSDYLRT---QRGLFSAetllgMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVVKVSDFGMTRFVLDDQYTSST-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPYlnENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 514
Cdd:cd05112  160 GTKFpvkWSSPEVFSFSRYSSKSDVWSFGVLMWEVFsEGKIPY--ENRSNSEVVEDINAGFRLYKPRLASTHVYEIMNHC 237
                        250
                 ....*....|....*...
gi 578838380 515 LEMDVDRRGSAKELLQVL 532
Cdd:cd05112  238 WKERPEDRPSFSLLLRQL 255
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
282-530 5.09e-20

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 91.30  E-value: 5.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIK----QMNLQQQPKKELIINEILVMRENKNP-NIVNYLDSYLVGDELWVV 356
Cdd:cd14225   44 RYEILEVIGKGSFGQVVKALDHKTNEHVAIKiirnKKRFHHQALVEVKILDALRRKDRDNShNVIHMKEYFYFRNHLCIT 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEyLAGGSLTDVVTETCMDEGQIAAVCREC---LQALDFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGF-CAqitpE 430
Cdd:cd14225  124 FE-LLGMNLYELIKKNNFQGFSLSLIRRFAislLQCLRLLYRERIIHCDLKPENILLRQRGqsSIKVIDFGSsCY----E 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-------------------- 490
Cdd:cd14225  199 HQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSLGCILAELYTGYPLFPGENEVEQLACIMevlglpppelienaqrrrlf 278
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 491 ----------TN--GTPELQNPERLSAV-------FRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14225  279 fdskgnprciTNskGKKRRPNSKDLASAlktsdplFLDFIRRCLEWDPSKRMTPDEALQ 337
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
353-482 5.17e-20

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 91.33  E-value: 5.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLT-DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd05588   71 LFFVIEFVNGGDLMfHMQRQRRLPEEHARFYSAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPG 150
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578838380 432 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY----LNENP 482
Cdd:cd05588  151 DTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMLAGRSPFdivgSSDNP 205
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
282-530 5.32e-20

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 90.66  E-value: 5.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQ----PKKELIINEILVMReNKNPNIVNYLDSYLVGDE----L 353
Cdd:cd07837    2 AYEKLEKIGEGTYGKVYKARDKNTGKLVALKKTRLEMEeegvPSTALREVSLLQML-SQSIYIVRLLDVEHVEENgkplL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGG-----SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQI 427
Cdd:cd07837   81 YLVFEYLDTDlkkfiDSYGRGPHNPLPAKTIQSFMYQLCKGVAHCHSHGVMHRDLKPQNLLVDKQkGLLKIADLGLGRAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQ------- 498
Cdd:cd07837  161 TIPIKSYTHEIVTLWYRAPEVLLGSThYSTPVDMWSVGCIFAEMSRKQPLFPGDSELQQLLHIfRLLGTPNEEvwpgvsk 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 499 ----------NPERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07837  241 lrdwheypqwKPQDLSRAVPdlepegvDLLTKMLAYDPAKRISAKAALQ 289
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
282-441 5.51e-20

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 89.82  E-value: 5.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIK-QMNLQQQPkkeLIINEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14016    1 RYKLVKKIGSGSFGEVYLGIDLKTGEEVAIKiEKKDSKHP---QLEYEAKVYKLlQGGPGIPRLYWFGQEGDYNVMVMDL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LaGGSLTDVVTE---------TCMdegqIAavcRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVK---LTDFGFCA-- 425
Cdd:cd14016   78 L-GPSLEDLFNKcgrkfslktVLM----LA---DQMISRLEYLHSKGYIHRDIKPENFLMGLGKNSNkvyLIDFGLAKky 149
                        170       180
                 ....*....|....*....|..
gi 578838380 426 --QIT----PEQSKRStMVGTP 441
Cdd:cd14016  150 rdPRTgkhiPYREGKS-LTGTA 170
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
279-477 6.99e-20

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 90.17  E-value: 6.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVY--TALDIATGQE----VAIKqMNLQQQPKKELI--INEILVMRE-NKNPNIVNYLDSYLV 349
Cdd:cd05053   10 PRDRLTLGKPLGEGAFGQVVkaEAVGLDNKPNevvtVAVK-MLKDDATEKDLSdlVSEMEMMKMiGKHKNIINLLGACTQ 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 350 GDELWVVMEYLAGGSLTD-----------------VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 412
Cdd:cd05053   89 DGPLYVVVEYASKGNLREflrarrppgeeaspddpRVPEEQLTQKDLVSFAYQVARGMEYLASKKCIHRDLAARNVLVTE 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578838380 413 DGSVKLTDFGFCAQITPEQSKRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05053  169 DNVMKIADFGLARDIHHIDYYRKTTNGrLPVkWMAPEALFDRVYTHQSDVWSFGVLLWEIFTlGGSPY 236
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
272-473 7.48e-20

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 91.26  E-value: 7.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 272 SIVSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLD 345
Cdd:cd07875   11 YSVEIGDSTftvlKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSrpFQNQTHAKRAYRELVLMKCVNHKNIIGLLN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 346 SYLVG------DELWVVMEyLAGGSLTDVVtETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 419
Cdd:cd07875   91 VFTPQksleefQDVYIVME-LMDANLCQVI-QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 168
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578838380 420 DFGFcAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEG 473
Cdd:cd07875  169 DFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKG 221
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
274-471 7.66e-20

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 91.30  E-value: 7.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 274 VSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
Cdd:cd07874    6 VEVGDSTftvlKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSrpFQNQTHAKRAYRELVLMKCVNHKNIISLLNVF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 348 LVGDEL------WVVMEyLAGGSLTDVVtETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd07874   86 TPQKSLeefqdvYLVME-LMDANLCQVI-QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 163
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFcAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV 471
Cdd:cd07874  164 GL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 212
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
289-530 8.77e-20

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 91.34  E-value: 8.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQM-NLQQQpkkelIINEILVMRENK------NPNIVNYLDSYLVGD-----ELWVV 356
Cdd:cd07853    8 IGYGAFGVVWSVTDPRDGKRVALKKMpNVFQN-----LVSCKRVFRELKmlcffkHDNVLSALDILQPPHidpfeEIYVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 436
Cdd:cd07853   83 TELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDESKHMT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 M-VGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIaTN--GTPELQN------------- 499
Cdd:cd07853  163 QeVVTQYYRAPEILMgSRHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLDLI-TDllGTPSLEAmrsacegarahil 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 500 -----PERLSAVFR----------DFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07853  242 rgphkPPSLPVLYTlssqatheavHLLCRMLVFDPDKRISAADALA 287
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
267-483 1.55e-19

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 90.04  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 267 LEKLRSIVSVGDPKK----KYTRFEKI---GQGASGTVYTA-LDIATGQEVAIKQM---NLQQQPKKELIINEILVMREN 335
Cdd:PTZ00426   9 LHKKKDSDSTKEPKRknkmKYEDFNFIrtlGTGSFGRVILAtYKNEDFPPVAIKRFeksKIIKQKQVDHVFSERKILNYI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 336 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--------CMDEGQIAAVcreclqaLDFLHSNQVIHRDIKSDN 407
Cdd:PTZ00426  89 NHPFCVNLYGSFKDESYLYLVLEFVIGGEFFTFLRRNkrfpndvgCFYAAQIVLI-------FEYLQSLNIVYRDLKPEN 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 408 ILLGMDGSVKLTDFGFCAQItpeQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPL 483
Cdd:PTZ00426 162 LLLDKDGFIKMTDFGFAKVV---DTRTYTLCGTPEYIAPEILLNVGHGKAADWWTLGIFIYEILVGCPPFYANEPL 234
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
289-478 1.56e-19

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 88.30  E-value: 1.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKqMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLtdv 368
Cdd:cd14155    1 IGSGFFSEVYKVRHRTSGQVMALK-MN-TLSSNRANMLREVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINGGNL--- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 369 vtETCMDEGQIAAVCRECLQALD------FLHSNQVIHRDIKSDNILLGMDG---SVKLTDFGFCAQItPEQSKRS---T 436
Cdd:cd14155   76 --EQLLDSNEPLSWTVRVKLALDiarglsYLHSKGIFHRDLTSKNCLIKRDEngyTAVVGDFGLAEKI-PDYSDGKeklA 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 437 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM---VEGEPPYL 478
Cdd:cd14155  153 VVGSPYWMAPEVLRGEPYNEKADVFSYGIILCEIiarIQADPDYL 197
CRIB_PAK_like cd01093
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
68-128 1.72e-19

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. This subgroup of CRIB/PBD-domains is found N-terminal of Serine/Threonine kinase domains in PAK and PAK-like proteins.


Pssm-ID: 238526  Cd Length: 46  Bit Score: 81.93  E-value: 1.72e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380  68 PEISLPSDFEHTIHVGFDAVTGEFTpdlygsqmcpgklpeGIPEQWARLLQTSNITKLEQK 128
Cdd:cd01093    1 PEISSPTNFKHRVHVGFDPQTGEFT---------------GLPEEWQRLLKSSGITKEEQK 46
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
287-529 2.78e-19

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 87.57  E-value: 2.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMnlqqqPKKELIINEILVMRENKNPNIVNYLDSYLV-GDELWVVMEYLAGGSL 365
Cdd:cd14109   10 EDEKRAAQGAPFHVTERSTGRNFLAQLR-----YGDPFLMREVDIHNSLDHPNIVQMHDAYDDeKLAVTVIDNLASTIEL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 --------TDVVTETCmdegqIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDgSVKLTDFGFCAQItpEQSKRSTM 437
Cdd:cd14109   85 vrdnllpgKDYYTERQ-----VAVFVRQLLLALKHMHDLGIAHLDLRPEDILLQDD-KLKLADFGQSRRL--LRGKLTTL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 V-GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP-ERLSAVFRDFLNRCL 515
Cdd:cd14109  157 IyGSPEFVSPEIVNSYPVTLATDMWSVGVLTYVLLGGISPFLGDNDRETLTNVRSGKWSFDSSPlGNISDDARDFIKKLL 236
                        250
                 ....*....|....
gi 578838380 516 EMDVDRRGSAKELL 529
Cdd:cd14109  237 VYIPESRLTVDEAL 250
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
289-477 3.57e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 88.39  E-value: 3.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEliiNEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd14180   14 LGEGSFSVCRKCRHRQSGQEYAVKIISRRMEANTQ---REVAALRLcQSHPNIVALHEVLHDQYHTYLVMELLRGGELLD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFcAQITPEQSK-RSTMVGTPY 442
Cdd:cd14180   91 RIKKKARfSESEASQLMRSLVSAVSFMHEAGVVHRDLKPENILYADESDgavLKVIDFGF-ARLRPQGSRpLQTPCFTLQ 169
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14180  170 YAAPELFSNQGYDESCDLWSLGVILYTMLSGQVPF 204
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
288-477 3.58e-19

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 88.50  E-value: 3.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTA--LDIATGQEVAIKQMnlqQQPKKELI------INEILVMRENKNPNIVNYLDSYLVGDE--LWVVM 357
Cdd:cd07842    7 CIGRGTYGRVYKAkrKNGKDGKEYAIKKF---KGDKEQYTgisqsaCREIALLRELKHENVVSLVEVFLEHADksVYLLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYlAGGSLTDVV-----TETCM-DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL----GMDGSVKLTDFGFcAQI 427
Cdd:cd07842   84 DY-AEHDLWQIIkfhrqAKRVSiPPSMVKSLLWQILNGIHYLHSNWVLHRDLKPANILVmgegPERGVVKIGDLGL-ARL 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 428 TPEQSKRST----MVGTPYWMAPEVVT-RKAYGPKVDIWSLG-IMAiEMVEGEPPY 477
Cdd:cd07842  162 FNAPLKPLAdldpVVVTIWYRAPELLLgARHYTKAIDIWAIGcIFA-ELLTLEPIF 216
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
283-495 3.84e-19

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 87.76  E-value: 3.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd07871    7 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTaIREVSLLKNLKHANIVTLHDIIHTERCLTLVFEYLD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GG---SLTDVVTETCMDEGQIAAVcrECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-AQITPEQSKRSTM 437
Cdd:cd07871   87 SDlkqYLDNCGNLMSMHNVKIFMF--QLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLArAKSVPTKTYSNEV 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VgTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP 495
Cdd:cd07871  165 V-TLWYRPPDVLLgSTEYSTPIDMWGVGCILYEMATGRPMFPGSTVKEELHLIfRLLGTP 223
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
283-528 4.32e-19

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 86.97  E-value: 4.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK---KELIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVME 358
Cdd:cd14163    2 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKSGGPEefiQRFLPRELQIVERLDHKNIIHVYEMLESADgKIYLVME 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDgsVKLTDFGFcAQITPEQSKR-- 434
Cdd:cd14163   82 LAEDGDVFDCVLHGGpLPEHRAKALFRQLVEAIRYCHGCGVAHRDLKCENALLqGFT--LKLTDFGF-AKQLPKGGREls 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYliatNGTPELQNPERL--SAVFRDFL 511
Cdd:cd14163  159 QTFCGSTAYAAPEVLQGVPHdSRKGDIWSMGVVLYVMLCAQLPFDDTDIPKMLC----QQQKGVSLPGHLgvSRTCQDLL 234
                        250
                 ....*....|....*..
gi 578838380 512 NRCLEMDVDRRGSAKEL 528
Cdd:cd14163  235 KRLLEPDMVLRPSIEEV 251
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
282-489 6.54e-19

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 88.30  E-value: 6.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV---------NYLDSYLVG-- 350
Cdd:cd07854    6 RYMDLRPLGCGSNGLVFSAVDSDCDKRVAVKKIVLTDPQSVKHALREIKIIRRLDHDNIVkvyevlgpsGSDLTEDVGsl 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 ---DELWVVMEYLAgGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCAQ 426
Cdd:cd07854   86 telNSVYIVQEYME-TDLANVLEQGPLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANVFINTEDLVlKIGDFGLARI 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 427 ITPEQSKR---STMVGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI 489
Cdd:cd07854  165 VDPHYSHKgylSEGLVTKWYRSPRLLLSpNNYTKAIDMWAAGCIFAEMLTGKPLFAGAHELEQMQLI 231
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
281-479 6.65e-19

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 87.27  E-value: 6.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-----ELIINEILVMRENknPNIVNYLDSYLVGDELWV 355
Cdd:cd05607    2 KYFYEFRVLGKGGFGEVCAVQVKNTGQMYACKKLDKKRLKKKsgekmALLEKEILEKVNS--PFIVSLAYAFETKTHLCL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLT---DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItPEQS 432
Cdd:cd05607   80 VMSLMNGGDLKyhiYNVGERGIEMERVIFYSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAVEV-KEGK 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 433 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN 479
Cdd:cd05607  159 PITQRAGTNGYMAPEILKEESYSYPVDWFAMGCSIYEMVAGRTPFRD 205
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
306-526 6.94e-19

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 86.68  E-value: 6.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 306 GQEVAIKQMNLQQQPKKElIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVC 383
Cdd:cd13992   25 GRTVAIKHITFSRTEKRT-ILQELNQLKELVHDNLNKFIGICINPPNIAVVTEYCTRGSLQDVllNREIKMDWMFKSSFI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 384 RECLQALDFLHSNQVI-HRDIKSDNILLGMDGSVKLTDFGfCAQITPEQSKRSTMVGTPY----WMAPEVVTRKAYG--- 455
Cdd:cd13992  104 KDIVKGMNYLHSSSIGyHGRLKSSNCLVDSRWVVKLTDFG-LRNLLEEQTNHQLDEDAQHkkllWTAPELLRGSLLEvrg 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 456 -PKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT----PEL-----QNPERLSAVFRDflnrCLEMDVDRRGSA 525
Cdd:cd13992  183 tQKGDVYSFAIILYEILFRSDPFALEREVAIVEKVISGGNkpfrPELavlldEFPPRLVLLVKQ----CWAENPEKRPSF 258

                 .
gi 578838380 526 K 526
Cdd:cd13992  259 K 259
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
283-510 8.52e-19

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 87.35  E-value: 8.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLa 361
Cdd:cd07872    8 YIKLEKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTaIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYL- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 ggsltDVVTETCMDE-GQIAAV------CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd07872   87 -----DKDLKQYMDDcGNIMSMhnvkifLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAV--FRDF 510
Cdd:cd07872  162 SNEVVTLWYRPPDVLLGSSeYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIfRLLGTPTEETWPGISSNdeFKNY 241
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
279-492 9.56e-19

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 86.33  E-value: 9.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALdIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05148    4 PREEFTLERKLGSGYFGEVWEGL-WKNRVRVAIKILKSDDLLKQQDFQKEVQALKRLRHKHLISLFAVCSVGEPVYIITE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTETcmdEGQIAAVCR------ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQS 432
Cdd:cd05148   83 LMEKGSLLAFLRSP---EGQVLPVASlidmacQVAEGMAYLEEQNSIHRDLAARNILVGEDLVCKVADFGL-ARLIKEDV 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 433 KRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATN 492
Cdd:cd05148  159 YLSSDKKIPYkWTAPEAASHGTFSTKSDVWSFGILLYEMFTyGQVPYPGMNNHEVYDQITAG 220
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
289-477 9.97e-19

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 86.64  E-value: 9.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd05605    8 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKgeaMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTIMNGGDL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 T---DVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTmVGTPY 442
Cdd:cd05605   88 KfhiYNMGNPGFEEERAVFYAAEITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPEGETIRGR-VGTVG 166
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578838380 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd05605  167 YMAPEVVKNERYTFSPDWWGLGCLIYEMIEGQAPF 201
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
283-533 1.01e-18

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 86.67  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd07844    2 YKKLDKLGEGSYATVYKGRSKLTGQLVALKEIRLEHEEGAPFTaIREASLLKDLKHANIVTLHDIIHTKKTLTLVFEYLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 ggslTDVVT--ETC---MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-AQITPEQSKRS 435
Cdd:cd07844   82 ----TDLKQymDDCgggLSMHNVRLFLFQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLArAKSVPSKTYSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVgTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYL-NENPLRALYLI-ATNGTPELQ-------NPERLSA 505
Cdd:cd07844  158 EVV-TLWYRPPDVLLgSTEYSTSLDMWGVGCIFYEMATGRPLFPgSTDVEDQLHKIfRVLGTPTEEtwpgvssNPEFKPY 236
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 506 VFRDFLNRCLEMDV---DRRGSAKELLQVLL 533
Cdd:cd07844  237 SFPFYPPRPLINHAprlDRIPHGEELALKFL 267
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
289-477 1.04e-18

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 87.02  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEliiNEILVMRE-NKNPNIVNYLDSYlvGDEL--WVVMEYLAGGSL 365
Cdd:cd14179   15 LGEGSFSICRKCLHKKTNQEYAVKIVSKRMEANTQ---REIAALKLcEGHPNIVKLHEVY--HDQLhtFLVMELLKGGEL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441
Cdd:cd14179   90 LErIKKKQHFSETEASHIMRKLVSAVSHMHDVGVVHRDLKPENLLFtdeSDNSEIKIIDFGFARLKPPDNQPLKTPCFTL 169
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 578838380 442 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14179  170 HYAAPELLNYNGYDESCDLWSLGVILYTMLSGQVPF 205
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
289-476 1.29e-18

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 86.01  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTaLDIATGQEVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd14664    1 IGRGGAGTVYK-GVMPNGTLVAVKRLKGEGTQGGDHgFQAEIQTLGMIRHRNIVRLRGYCSNPTTNLLVYEYMPNGSLGE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTETCMDEGQI--AAVCRECLQA---LDFLH---SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV- 438
Cdd:cd14664   80 LLHSRPESQPPLdwETRQRIALGSargLAYLHhdcSPLIIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDSHVMSSVa 159
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578838380 439 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 476
Cdd:cd14664  160 GSYGYIAPEYAYTGKVSEKSDVYSYGVVLLELITGKRP 197
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
279-532 1.33e-18

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 86.18  E-value: 1.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVY--TALDIATGQ---EVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd05061    4 SREKITLLRELGQGSFGMVYegNARDIIKGEaetRVAVKTVNESASLRERIeFLNEASVMKGFTCHHVVRLLGVVSKGQP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVV----TETCMDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd05061   84 TLVVMELMAHGDLKSYLrslrPEAENNPGRPPPTLQEMIQmaaeiadGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTpeLQ 498
Cdd:cd05061  164 GMTRDIYETDYYRKGGKGlLPVrWMAPESLKDGVFTTSSDMWSFGVVLWEITSlAEQPYQGLSNEQVLKFVMDGGY--LD 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 578838380 499 NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05061  242 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 275
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
282-532 1.73e-18

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 85.93  E-value: 1.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKI---GQGASGTVYTALDIATGQ----EVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLvGDEL 353
Cdd:cd05057    5 KETELEKGkvlGSGAFGTVYKGVWIPEGEkvkiPVAIKVLREETGPKaNEEILDEAYVMASVDHPHLVRLLGICL-SSQV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd05057   84 QLITQLMPLGCLLDYVRNhrDNIGSQLLLNWCVQIAKGMSYLEEKRLVHRDLAARNVLVKTPNHVKITDFGLAKLLDVDE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLNEnPLRALYLIATNGTpELQNPERLSAVFR 508
Cdd:cd05057  164 KEYHAEGGkVPIkWMALESIQYRIYTHKSDVWSYGVTVWElMTFGAKPYEGI-PAVEIPDLLEKGE-RLPQPPICTIDVY 241
                        250       260
                 ....*....|....*....|....
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05057  242 MVLVKCWMIDAESRPTFKELANEF 265
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
286-470 1.90e-18

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 85.84  E-value: 1.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTV----YTALDIATGQEVAIKQmnLQQQPKKEL--IINEILVMRENKNPNIVNYLD-SYLVG-DELWVVM 357
Cdd:cd14205    9 LQQLGKGNFGSVemcrYDPLQDNTGEVVAVKK--LQHSTEEHLrdFEREIEILKSLQHDNIVKYKGvCYSAGrRNLRLIM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPeQSKRS 435
Cdd:cd14205   87 EYLPYGSLRDYLQKHKerIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGL-TKVLP-QDKEY 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTP-----YWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd14205  165 YKVKEPgespiFWYAPESLTESKFSVASDVWSFGVVLYEL 204
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
281-532 2.10e-18

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 84.92  E-value: 2.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALdiATGQEVAIKqmNLQQQPKKELIINEILVMRENKNPNIVNYLdSYLVGDELWVVMEYL 360
Cdd:cd05083    6 QKLTLGEIIGEGEFGAVLQGE--YMGQKVAVK--NIKCDVTAQAFLEETAVMTKLQHKNLVRLL-GVILHNGLYIVMELM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTM 437
Cdd:cd05083   81 SKGNLVNFLRsrgRALVPVIQLLQFSLDVAEGMEYLESKKLVHRDLAARNILVSEDGVAKISDFGL-AKVGSMGVDNSRL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 vgtPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYlnenPLRALYLI--ATNGTPELQNPERLSAVFRDFLNR 513
Cdd:cd05083  160 ---PVkWTAPEALKNKKFSSKSDVWSYGVLLWEVFSyGRAPY----PKMSVKEVkeAVEKGYRMEPPEGCPPDVYSIMTS 232
                        250
                 ....*....|....*....
gi 578838380 514 CLEMDVDRRGSAKELLQVL 532
Cdd:cd05083  233 CWEAEPGKRPSFKKLREKL 251
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
289-528 2.67e-18

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 85.18  E-value: 2.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINE----ILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd05606    2 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQgetLALNErimlSLVSTGGDCPFIVCMTYAFQTPDKLCFILDLMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRStmVGT 440
Cdd:cd05606   82 GGDLHYHLSQhGVFSEAEMRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
Cdd:cd05606  160 HGYMAPEVLQKgVAYDSSADWFSLGCMLYKLLKGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFSPELKSLLEGLLQRDV 239
                        250
                 ....*....|....
gi 578838380 520 DRR-----GSAKEL 528
Cdd:cd05606  240 SKRlgclgRGATEV 253
pknD PRK13184
serine/threonine-protein kinase PknD;
282-532 3.45e-18

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 88.67  E-value: 3.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMnlqqqpKKELIINEIL---VMRENK------NPNIVNYLDSYLVGDE 352
Cdd:PRK13184   3 RYDIIRLIGKGGMGEVYLAYDPVCSRRVALKKI------REDLSENPLLkkrFLREAKiaadliHPGIVPVYSICSDGDP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLT---------DVVTETCMDEGQIAA-------VCreclQALDFLHSNQVIHRDIKSDNILLGMDGSV 416
Cdd:PRK13184  77 VYYTMPYIEGYTLKsllksvwqkESLSKELAEKTSVGAflsifhkIC----ATIEYVHSKGVLHRDLKPDNILLGLFGEV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 417 KLTDFGFCAQITPEQ------------SKRSTM------VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL 478
Cdd:PRK13184 153 VILDWGAAIFKKLEEedlldidvdernICYSSMtipgkiVGTPDYMAPERLLGVPASESTDIYALGVILYQMLTLSFPYR 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 479 NENpLRALYLIATNGTPELQNPER-----LSAVfrdfLNRCLEMD-VDRRGSAKELLQVL 532
Cdd:PRK13184 233 RKK-GRKISYRDVILSPIEVAPYReippfLSQI----AMKALAVDpAERYSSVQELKQDL 287
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
274-478 3.58e-18

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 85.71  E-value: 3.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 274 VSVGDP-KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKqmnLQQQPKK--ELIINEILVMRE--NKNP------NIVN 342
Cdd:cd14136    2 VKIGEVyNGRYHVVRKLGWGHFSTVWLCWDLQNKRFVALK---VVKSAQHytEAALDEIKLLKCvrEADPkdpgreHVVQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 343 YLDSYLV----GDELWVVMEYLaGGSLTDVVtETCMDEG-QIAAV---CRECLQALDFLHSN-QVIHRDIKSDNILLGMD 413
Cdd:cd14136   79 LLDDFKHtgpnGTHVCMVFEVL-GPNLLKLI-KRYNYRGiPLPLVkkiARQVLQGLDYLHTKcGIIHTDIKPENVLLCIS 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838380 414 GS-VKLTDFG--------FCAQITPEQskrstmvgtpyWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEppYL 478
Cdd:cd14136  157 KIeVKIADLGnacwtdkhFTEDIQTRQ-----------YRSPEVILGAGYGTPADIWSTACMAFELATGD--YL 217
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
328-549 3.69e-18

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 84.52  E-value: 3.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 328 EILV---MRenKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDI 403
Cdd:PHA03390  58 EPMVhqlMK--DNPNFIKLYYSVTTLKGHVLIMDYIKDGDLFDLLkKEGKLSEAEVKKIIRQLVEALNDLHKHNIIHNDI 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 404 KSDNILL--GMDgSVKLTDFGFCAQI-TPeqskrSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY--- 477
Cdd:PHA03390 136 KLENVLYdrAKD-RIYLCDYGLCKIIgTP-----SCYDGTLDYFSPEKIKGHNYDVSFDWWAVGVLTYELLTGKHPFked 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 478 ----LNENPLRALYliatngTPELQNPERLSAVFRDFLNRCLEMDVDRRgsakellqvllaggnsLHNY-AIISMAF 549
Cdd:PHA03390 210 edeeLDLESLLKRQ------QKKLPFIKNVSKNANDFVQSMLKYNINYR----------------LTNYnEIIKHPF 264
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
287-465 3.99e-18

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 85.11  E-value: 3.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALdiATGQEVAIK--QMNLQQQPKKELIINEILVMRenkNPNIVNYL--DSYLVGDELW---VVMEY 359
Cdd:cd14054    1 QLIGQGRYGTVWKGS--LDERPVAVKvfPARHRQNFQNEKDIYELPLME---HSNILRFIgaDERPTADGRMeylLVLEY 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ---------VIHRDIKSDNILLGMDGSVKLTDFGFCAQIT-- 428
Cdd:cd14054   76 APKGSLCSYLRENTLDWMSSCRMALSLTRGLAYLHTDLrrgdqykpaIAHRDLNSRNVLVKADGSCVICDFGLAMVLRgs 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 429 --------PEQSKRSTMVGTPYWMAPEVV-------TRKAYGPKVDIWSLGI 465
Cdd:cd14054  156 slvrgrpgAAENASISEVGTLRYMAPEVLegavnlrDCESALKQVDVYALGL 207
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
289-534 4.68e-18

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 84.39  E-value: 4.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVY--TALDI---ATG-QEVAIKqmNLQQ----QPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05044    3 LGSGAFGEVFegTAKDIlgdGSGeTKVAVK--TLRKgatdQEKAEFL-KEAHLMSNFKHPNILKLLGVCLDNDPQYIILE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGG-------------------SLTDVVtETCMDegqiaaVCREC--LQALDFlhsnqvIHRDIKSDNILLGMDGS-- 415
Cdd:cd05044   80 LMEGGdllsylraarptaftppllTLKDLL-SICVD------VAKGCvyLEDMHF------VHRDLAARNCLVSSKDYre 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 416 --VKLTDFGFCAQITPEQSKRSTMVGT-PY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLNENPLRALYLIA 490
Cdd:cd05044  147 rvVKIGDFGLARDIYKNDYYRKEGEGLlPVrWMAPESLVDGVFTTQSDVWAFGVLMWEiLTLGQQPYPARNNLEVLHFVR 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 578838380 491 TNGtpELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd05044  227 AGG--RLDQPDNCPDDLYELMLRCWSTDPEERPSFARILEQLQN 268
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
286-532 4.78e-18

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 84.32  E-value: 4.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTVYTALdiaTGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd14063    5 KEVIGKGRFGRVHRGR---WHGDVAIKllNIDYLNEEQLEAFKEEVAAYKNTRHDNLVLFMGACMDPPHLAIVTSLCKGR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGmDGSVKLTDFGF--CAQITPEQSKRSTMVG 439
Cdd:cd14063   82 TLYSLIHErkEKFDFNKTVQIAQQICQGMGYLHAKGIIHKDLKSKNIFLE-NGRVVITDFGLfsLSGLLQPGRREDTLVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPYW---MAPEVVT----------RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNpERLSAV 506
Cdd:cd14063  161 PNGWlcyLAPEIIRalspdldfeeSLPFTKASDVYAFGTVWYELLAGRWPFKEQPAESIIWQVGCGKKQSLSQ-LDIGRE 239
                        250       260
                 ....*....|....*....|....*.
gi 578838380 507 FRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14063  240 VKDILMQCWAYDPEKRPTFSDLLRML 265
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
278-477 5.75e-18

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 83.78  E-value: 5.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKkYTRFEKIGQGASGTVytALDIATGQ-EVAIKQMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd05113    2 DPKD-LTFLKELGTGQFGVV--KYGKWRGQyDVAIKMIKEGSMSEDEFI-EEAKVMMNLSHEKLVQLYGVCTKQRPIFII 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd05113   78 TEYMANGCLLNYLREMRkrFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTS 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 435 StmVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05113  158 S--VGSKFpvrWSPPEVLMYSKFSSKSDVWAFGVLMWEVYSlGKMPY 202
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
283-530 5.89e-18

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 84.67  E-value: 5.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLa 361
Cdd:cd07873    4 YIKLDKLGEGTYATVYKGRSKLTDNLVALKEIRLEHEEGAPCTaIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTE--TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC-AQITPEQSKRSTMV 438
Cdd:cd07873   83 DKDLKQYLDDcgNSINMHNVKLFLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLArAKSIPTKTYSNEVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 gTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPE-------LQNPE-------- 501
Cdd:cd07873  163 -TLWYRPPDILLGSTdYSTQIDMWGVGCIFYEMSTGRPLFPGSTVEEQLHFIfRILGTPTeetwpgiLSNEEfksynypk 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 578838380 502 -----------RLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd07873  242 yradalhnhapRLDSDGADLLSKLLQFEGRKRISAEEAMK 281
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
289-522 6.51e-18

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 85.10  E-value: 6.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMR---ENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd14223    8 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQgetLALNERIMLSlvsTGDCPFIVCMSYAFHTPDKLSFILDLMNG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRStmVGTP 441
Cdd:cd14223   88 GDLHYHLSQhGVFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSKKKPHAS--VGTH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEVVTRK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVD 520
Cdd:cd14223  166 GYMAPEVLQKGvAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 245

                 ..
gi 578838380 521 RR 522
Cdd:cd14223  246 RR 247
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
287-477 1.11e-17

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 83.48  E-value: 1.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALdiATGQEVAIKQMNLQQQP--KKELIINEILVMRenkNPNIVNYLDSYLVGD----ELWVVMEYL 360
Cdd:cd14056    1 KTIGKGRYGEVWLGK--YRGEKVAVKIFSSRDEDswFRETEIYQTVMLR---HENILGFIAADIKSTgswtQLWLITEYH 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN--------QVIHRDIKSDNILLGMDGSVKLTDFG----FCAQIT 428
Cdd:cd14056   76 EHGSLYDYLQRNTLDTEEALRLAYSAASGLAHLHTEivgtqgkpAIAHRDLKSKNILVKRDGTCCIADLGlavrYDSDTN 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 429 PEQSKRSTMVGTPYWMAPEVVTrKAYGPK-------VDIWSLGIMAIEMV----------EGEPPY 477
Cdd:cd14056  156 TIDIPPNPRVGTKRYMAPEVLD-DSINPKsfesfkmADIYSFGLVLWEIArrceiggiaeEYQLPY 220
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
283-495 1.24e-17

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 84.38  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQE--VAIKQM-NLQQqpKKELI---INEILVMRENKN-PNIVNYLDSYLVG----D 351
Cdd:cd07857    2 YELIKELGQGAYGIVCSARNAETSEEetVAIKKItNVFS--KKILAkraLRELKLLRHFRGhKNITCLYDMDIVFpgnfN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEyLAGGSLTDVV-TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP- 429
Cdd:cd07857   80 ELYLYEE-LMEADLHQIIrSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSEn 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 430 ---EQSKRSTMVGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP 495
Cdd:cd07857  159 pgeNAGFMTEYVATRWYRAPEImLSFQSYTKAIDVWSVGCILAELLGRKPVFKGKDYVDQLNQIlQVLGTP 229
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
287-465 1.70e-17

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 82.86  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQE---VAIKQMNLQQQP-KKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVMEYLAG 362
Cdd:cd05056   12 RCIGEGQFGDVYQGVYMSPENEkiaVAVKTCKNCTSPsVREKFLQEAYIMRQFDHPHIVK-LIGVITENPVWIVMELAPL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVtETCMDEGQIAAVCRECLQ---ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVG 439
Cdd:cd05056   91 GELRSYL-QVNKYSLDLASLILYAYQlstALAYLESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYMEDESYYKASKGK 169
                        170       180
                 ....*....|....*....|....*..
gi 578838380 440 TPY-WMAPEVVTRKAYGPKVDIWSLGI 465
Cdd:cd05056  170 LPIkWMAPESINFRRFTSASDVWMFGV 196
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
289-499 2.28e-17

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 81.94  E-value: 2.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQ------QQPKKELIINEILVMRENKN--PNIVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14100    8 LGSGGFGSVYSGIRVADGAPVAIKHVEKDrvsewgELPNGTRVPMEIVLLKKVGSgfRGVIRLLDWFERPDSFVLVLERP 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AG-GSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQItpEQSKRSTM 437
Cdd:cd14100   88 EPvQDLFDFITERgALPEELARSFFRQVLEAVRHCHNCGVLHRDIKDENILIDLNtGELKLIDFGSGALL--KDTVYTDF 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838380 438 VGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTPELQN 499
Cdd:cd14100  166 DGTRVYSPPEWIRFHRYhGRSAAVWSLGILLYDMVCGDIPFeHDEEIIRGQVFFRQRVSSECQH 229
PKc_CLK cd14134
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity ...
273-474 2.58e-17

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on S/T residues. In Drosophila, the CLK homolog DOA (Darkener of apricot) is essential for embryogenesis and its mutation leads to defects in sexual differentiation, eye formation, and neuronal development. In fission yeast, the CLK homolog Lkh1 is a negative regulator of filamentous growth and asexual flocculation, and is also involved in oxidative stress response. Vertebrates contain mutliple CLK proteins and mammals have four (CLK1-4). The CLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271036 [Multi-domain]  Cd Length: 332  Bit Score: 83.38  E-value: 2.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 273 IVSVGDP-KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQM-NLQ---QQPKKELIINEILVMRENKN-PNIVNYLDS 346
Cdd:cd14134    3 IYKPGDLlTNRYKILRLLGEGTFGKVLECWDRKRKRYVAVKIIrNVEkyrEAAKIEIDVLETLAEKDPNGkSHCVQLRDW 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 347 YLVGDELWVVMEYLaGGSLTDVVTETC-----MDegQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLgMDGS------ 415
Cdd:cd14134   83 FDYRGHMCIVFELL-GPSLYDFLKKNNygpfpLE--HVQHIAKQLLEAVAFLHDLKLTHTDLKPENILL-VDSDyvkvyn 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 416 --------------VKLTDFGFCaqiTPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 474
Cdd:cd14134  159 pkkkrqirvpkstdIKLIDFGSA---TFDDEYHSSIVSTRHYRAPEVILGLGWSYPCDVWSIGCILVELYTGE 228
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
289-470 3.56e-17

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 81.86  E-value: 3.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTV----YTALDIATGQEVAIKQmnLQQQPKKEL--IINEILVMRENKNPNIVNYLD-SYLVG-DELWVVMEYL 360
Cdd:cd05081   12 LGKGNFGSVelcrYDPLGDNTGALVAVKQ--LQHSGPDQQrdFQREIQILKALHSDFIVKYRGvSYGPGrRSLRLVMEYL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPeQSKRSTMV 438
Cdd:cd05081   90 PSGCLRDFLqrHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGL-AKLLP-LDKDYYVV 167
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578838380 439 GTP-----YWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Cdd:cd05081  168 REPgqspiFWYAPESLSDNIFSRQSDVWSFGVVLYEL 204
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
290-530 5.42e-17

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 81.60  E-value: 5.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 290 GQGASGTVYTALDIATGQEVAI-----KQMNLQQQPKKELIInEILV-----MRENKNPNIVNYLDSYLVGDE-LWVVME 358
Cdd:cd14011    5 GPGLPWKIYNGSKKSTKQEVSVfvfekKQLEEYSKRDREQIL-ELLKrgvkqLTRLRHPRILTVQHPLEESREsLAFATE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGgSLTDVVTET--------CMDEGQIAAV--CRECLQ---ALDFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFC 424
Cdd:cd14011   84 PVFA-SLANVLGERdnmpspppELQDYKLYDVeiKYGLLQiseALSFLHNDVkLVHGNICPESVVINSNGEWKLAGFDFC 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 425 AQITP-----------EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPYLNENPLRALY-LIAT 491
Cdd:cd14011  163 ISSEQatdqfpyfreyDPNLPPLAQPNLNYLAPEYILSKTCDPASDMFSLGVLIYAIYnKGKPLFDCVNNLLSYKkNSNQ 242
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 578838380 492 NGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14011  243 LRQLSLSLLEKVPEELRDHVKTLLNVTPEVRPDAEQLSK 281
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
289-498 6.22e-17

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 80.77  E-value: 6.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMnLQQQPKKELIINEILVMRE----NKNPN----IVNYLDSYLVGDELWVVMEYL 360
Cdd:cd14102    8 LGSGGFGTVYAGSRIADGLPVAVKHV-VKERVTEWGTLNGVMVPLEivllKKVGSgfrgVIKLLDWYERPDGFLIVMERP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 A-GGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQItpEQSKRSTM 437
Cdd:cd14102   87 EpVKDLFDFITEKgALDEDTARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDLrTGELKLIDFGSGALL--KDTVYTDF 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 438 VGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTPELQ 498
Cdd:cd14102  165 DGTRVYSPPEWIRYHRYhGRSATVWSLGVLLYDMVCGDIPFeQDEEILRGRLYFRRRVSPECQ 227
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
241-509 7.26e-17

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 83.16  E-value: 7.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 241 ENANSStlyrNTDRQRKKSKMTDEEILeklRSivsvgdPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQP 320
Cdd:PTZ00036  39 ERSHNN----NAGEDEDEEKMIDNDIN---RS------PNKSYKLGNIIGNGSFGVVYEAICIDTSEKVAIKKVLQDPQY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 321 KKEliinEILVMRENKNPNIVnYLDSYLVGDE---------LWVVMEYLAGG--------SLTDVVTETCMDEGQIAAVC 383
Cdd:PTZ00036 106 KNR----ELLIMKNLNHINII-FLKDYYYTECfkkneknifLNVVMEFIPQTvhkymkhyARNNHALPLFLVKLYSYQLC 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 384 ReclqALDFLHSNQVIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQsKRSTMVGTPYWMAPEVVTRKA-YGPKVDIW 461
Cdd:PTZ00036 181 R----ALAYIHSKFICHRDLKPQNLLIDPNThTLKLCDFGSAKNLLAGQ-RSVSYICSRFYRAPELMLGATnYTTHIDLW 255
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578838380 462 SLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTP-----ELQNPERLSAVFRD 509
Cdd:PTZ00036 256 SLGCIIAEMILGYPIFSGQSSVDQLVrIIQVLGTPtedqlKEMNPNYADIKFPD 309
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
283-495 7.91e-17

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 81.28  E-value: 7.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYla 361
Cdd:cd07869    7 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTaIREASLLKGLKHANIVLLHDIIHTKETLTLVFEY-- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 ggsltdVVTETC--MDE-------GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd07869   85 ------VHTDLCqyMDKhpgglhpENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSH 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578838380 433 KRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLN----ENPLRALYLIAtnGTP 495
Cdd:cd07869  159 TYSNEVVTLWYRPPDVLLgSTEYSTCLDMWGVGCIFVEMIQGVAAFPGmkdiQDQLERIFLVL--GTP 224
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
287-483 8.52e-17

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 80.95  E-value: 8.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTA-LDiatGQEVAIKQMNLQ--QQPKKELIINEILVMrenKNPNIVNYLDS----YLVGDELWVVMEY 359
Cdd:cd13998    1 EVIGKGRFGEVWKAsLK---NEPVAVKIFSSRdkQSWFREKEIYRTPML---KHENILQFIAAderdTALRTELWLVTAF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI---------HRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd13998   75 HPNGSL*DYLSLHTIDWVSLCRLALSVARGLAHLHSEIPGctqgkpaiaHRDLKSKNILVKNDGTCCIADFGLAVRLSPS 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838380 431 QSK----RSTMVGTPYWMAPEV------VTRKAYGPKVDIWSLGIMAIEMV-----------EGEPPYLNENPL 483
Cdd:cd13998  155 TGEednaNNGQVGTKRYMAPEVlegainLRDFESFKRVDIYAMGLVLWEMAsrctdlfgiveEYKPPFYSEVPN 228
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
289-522 1.04e-16

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 81.65  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMR---ENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
Cdd:cd05633   13 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQgetLALNERIMLSlvsTGDCPFIVCMTYAFHTPDKLCFILDLMNG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRStmVGTP 441
Cdd:cd05633   93 GDLHYHLSQhGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTH 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 YWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVD 520
Cdd:cd05633  171 GYMAPEVLQKgTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDSFSPELKSLLEGLLQRDVS 250

                 ..
gi 578838380 521 RR 522
Cdd:cd05633  251 KR 252
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
287-532 1.60e-16

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 79.59  E-value: 1.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS- 364
Cdd:cd05084    2 ERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDlKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDf 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQitpEQ----SKRSTMVG 439
Cdd:cd05084   82 LTFLRTEGPrLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSRE---EEdgvyAATGGMKQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 440 TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLN-------ENPLRALYLIATNGTPElqnperlsAVFRdF 510
Cdd:cd05084  159 IPVkWTAPEALNYGRYSSESDVWSFGILLWETFSlGAVPYANlsnqqtrEAVEQGVRLPCPENCPD--------EVYR-L 229
                        250       260
                 ....*....|....*....|..
gi 578838380 511 LNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05084  230 MEQCWEYDPRKRPSFSTVHQDL 251
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
286-522 1.72e-16

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 79.85  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 286 FEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDsyLVGDELWVVMEYLAGG 363
Cdd:cd14025    1 WEKVGSGGFGQVYKVRHKHWKTWLAIKCPPSLHVDDSERmeLLEEAKKMEMAKFRHILPVYG--ICSEPVGLVMEYMETG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFC---AQITPEQSKRSTMV 438
Cdd:cd14025   79 SLEKLLASEPLPWELRFRIIHETAVGMNFLHCMKppLLHLDLKPANILLDAHYHVKISDFGLAkwnGLSHSHDLSRDGLR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPYWMAPEVVTRK--AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PEL-----QNPERLSAVFrDF 510
Cdd:cd14025  159 GTIAYLPPERFKEKnrCPDTKHDVYSFAIVIWGILTQKKPFAGENNILHIMVKVVKGHrPSLspiprQRPSECQQMI-CL 237
                        250
                 ....*....|..
gi 578838380 511 LNRCLEMDVDRR 522
Cdd:cd14025  238 MKRCWDQDPRKR 249
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
281-479 2.10e-16

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 79.56  E-value: 2.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEK-IGQGASGTV----YTALDIATGQEVAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLD--SYLVGDE 352
Cdd:cd05080    3 KRYLKKIRdLGEGHFGKVslycYDPTNDGTGEMVAVKALKADCGPQhRSGWKQEIDILKTLYHENIVKYKGccSEQGGKS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-TPEQ 431
Cdd:cd05080   83 LQLIMEYVPLGSLRDYLPKHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVpEGHE 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 432 SKRSTMVG-TP-YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN 479
Cdd:cd05080  163 YYRVREDGdSPvFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQS 212
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
387-466 4.96e-16

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 78.30  E-value: 4.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 387 LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCaqiTPEQSKRSTMVGTPYWMAPEVVTRKaYGPKVDIWSLGIM 466
Cdd:cd13975  112 VEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFC---KPEAMMSGSIVGTPIHMAPELFSGK-YDNSVDVYAFGIL 187
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
282-479 5.26e-16

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 78.18  E-value: 5.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEK-IGQGASGTVYTALDIATGQE---VAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd05033    4 SYVTIEKvIGGGEFGEVCSGSLKLPGKKeidVAIKTLKSGYSDKQRLdFLTEASIMGQFDHPNVIRLEGVVTKSRPVMIV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETcmDE----GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd05033   84 TEYMENGSLDKFLREN--DGkftvTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSRRLEDSEA 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 KRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLN 479
Cdd:cd05033  162 TYTTKGGkIPIrWTAPEAIAYRKFTSASDVWSFGIVMWEvMSYGERPYWD 211
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
289-485 1.01e-15

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 77.18  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALdiATGQEVAIKQ---MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG-DELWVVMEYLAGGS 364
Cdd:cd14064    1 IGSGSFGKVYKGR--CRNKIVAIKRyraNTYCSKSDVDMFCREVSILCRLNHPCVIQFVGACLDDpSQFAIVTQYVSGGS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTET--CMDEGQIAAVCRECLQALDFLH--SNQVIHRDIKSDNILLGMDGSVKLTDFG---FCAQItpEQSKRSTM 437
Cdd:cd14064   79 LFSLLHEQkrVIDLQSKLIIAVDVAKGMEYLHnlTQPIIHRDLNSHNILLYEDGHAVVADFGesrFLQSL--DEDNMTKQ 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 438 VGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 485
Cdd:cd14064  157 PGNLRWMAPEVFTQCTrYSIKADVFSYALCLWELLTGEIPFAHLKPAAA 205
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
287-479 1.12e-15

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 77.82  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEV----AIKQMNLQQQPKKELIINEIL-----VMRENKNPNIVNY--LDSYLVGDeLWV 355
Cdd:cd14001    5 KKLGYGTGVNVYLMKRSPRGGSSrspwAVKKINSKCDKGQRSLYQERLkeeakILKSLNHPNIVGFraFTKSEDGS-LCL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLaGGSLTDVVTETcMDEG-------QIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMD-GSVKLTDFGFCAQ 426
Cdd:cd14001   84 AMEYG-GKSLNDLIEER-YEAGlgpfpaaTILKVALSIARALEYLHNEkKILHGDIKSGNVLIKGDfESVKLCDFGVSLP 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 427 ITPEQSKRST----MVGTPYWMAPE------VVTRKAygpkvDIWSLGIMAIEMVEGEPPYLN 479
Cdd:cd14001  162 LTENLEVDSDpkaqYVGTEPWKAKEaleeggVITDKA-----DIFAYGLVLWEMMTLSVPHLN 219
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
287-532 1.27e-15

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 77.00  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAL-DIATGQE--VAIKQM--NLQQQPKKElIINEILVMRENKNPNIVNyLDSYLVGDELWVVMEYLA 361
Cdd:cd05060    1 KELGHGNFGSVRKGVyLMKSGKEveVAVKTLkqEHEKAGKKE-FLREASVMAQLDHPCIVR-LIGVCKGEPLMLVMELAP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcaqitpeqsKRSTMVGT 440
Cdd:cd05060   79 LGPLLKyLKKRREIPVSDLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGM---------SRALGAGS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PY------------WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGtpELQNPERLSAVF 507
Cdd:cd05060  150 DYyrattagrwplkWYAPECINYGKFSSKSDVWSYGVTLWEAFSyGAKPYGEMKGPEVIAMLESGE--RLPRPEECPQEI 227
                        250       260
                 ....*....|....*....|....*
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05060  228 YSIMLSCWKYRPEDRPTFSELESTF 252
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
282-545 1.47e-15

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 76.99  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKI---GQGASGTVYTALDIATGQE----VAIKQMNLQQQPK--KElIINEILVMRENKNPNIVNYLDSYLVgDE 352
Cdd:cd05109    5 KETELKKVkvlGSGAFGTVYKGIWIPDGENvkipVAIKVLRENTSPKanKE-ILDEAYVMAGVGSPYVCRLLGICLT-ST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTEtcmDEGQIAAV-----CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 427
Cdd:cd05109   83 VQLVTQLMPYGCLLDYVRE---NKDRIGSQdllnwCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKRSTMVG-TPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYlNENPLRALYLIATNGTPELQNPERLS 504
Cdd:cd05109  160 DIDETEYHADGGkVPIkWMALESILHRRFTHQSDVWSYGVTVWElMTFGAKPY-DGIPAREIPDLLEKGERLPQPPICTI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 505 AVFRdFLNRCLEMDVDRRGSAKELLQVLLAGGNSLHNYAII 545
Cdd:cd05109  239 DVYM-IMVKCWMIDSECRPRFRELVDEFSRMARDPSRFVVI 278
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
289-532 1.52e-15

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 77.53  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQE-----VAIKQMN-LQQQPKKELIINEILVMRE-NKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd05055   43 LGAGAFGKVVEATAYGLSKSdavmkVAVKMLKpTAHSSEREALMSELKIMSHlGNHENIVNLLGACTIGGPILVITEYCC 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRS 435
Cdd:cd05055  123 YGDLLNFLrrkRESFLTLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICDFGLARDIMNDSnyvVKGN 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPyWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY----LNENplraLYLIATNGTPELQnPERLSAVFRDF 510
Cdd:cd05055  203 ARLPVK-WMAPESIFNCVYTFESDVWSYGILLWEIFSlGSNPYpgmpVDSK----FYKLIKEGYRMAQ-PEHAPAEIYDI 276
                        250       260
                 ....*....|....*....|..
gi 578838380 511 LNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05055  277 MKTCWDADPLKRPTFKQIVQLI 298
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
289-532 1.89e-15

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 76.88  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALdiATGQEVAIKQMN---------------LQQQPKKELIIN------EILVMRENKNPNIVnyldsY 347
Cdd:cd14000    2 LGDGGFGSVYRAS--YKGEPVAVKIFNkhtssnfanvpadtmLRHLRATDAMKNfrllrqELTVLSHLHHPSIV-----Y 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 348 LVG---DELWVVMEYLAGGSLTDVVTEtcmDEGQIAAVCRECLQ--------ALDFLHSNQVIHRDIKSDNILL-GMDGS 415
Cdd:cd14000   75 LLGigiHPLMLVLELAPLGSLDHLLQQ---DSRSFASLGRTLQQrialqvadGLRYLHSAMIIYRDLKSHNVLVwTLYPN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 416 ----VKLTDFGFCAQITPEQSKrsTMVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 490
Cdd:cd14000  152 saiiIKIADYGISRQCCRMGAK--GSEGTPGFRAPEIARGNViYNEKVDVFSFGMLLYEILSGGAPMVGHLKFPNEFDIH 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 491 TNGTPELQNPErlSAVFR---DFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14000  230 GGLRPPLKQYE--CAPWPeveVLMKKCWKENPQQRPTAVTVVSIL 272
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
287-530 2.05e-15

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 76.54  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGT-VYTAldIATGQEVAIKQMNLQQQpkkELIINEILVMRENKN-PNIVNYLDSYLVGDELWVVMEyLAGGS 364
Cdd:cd13982    7 KVLGYGSEGTiVFRG--TFDGRPVAVKRLLPEFF---DFADREVQLLRESDEhPNVIRYFCTEKDRQFLYIALE-LCAAS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVT--ETCMDEGQIAAVCRECLQ----ALDFLHSNQVIHRDIKSDNILLGMDGS-----VKLTDFGFCAQITPEQS- 432
Cdd:cd13982   81 LQDLVEspRESKLFLRPGLEPVRLLRqiasGLAHLHSLNIVHRDLKPQNILISTPNAhgnvrAMISDFGLCKKLDVGRSs 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 433 --KRSTMVGTPYWMAPEV--------VTRkaygpKVDIWSLG-IMAIEMVEGEPPYlnENPLRALYLIATN--GTPELQN 499
Cdd:cd13982  161 fsRRSGVAGTSGWIAPEMlsgstkrrQTR-----AVDIFSLGcVFYYVLSGGSHPF--GDKLEREANILKGkySLDKLLS 233
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 500 PERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd13982  234 LGEHGPEAQDLIERMIDFDPEKRPSAEEVLN 264
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
285-477 2.49e-15

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 76.65  E-value: 2.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RF-EKIGQGASGTVYTALDIATGQE-----VAIKQMNLQQQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 357
Cdd:cd05048    8 RFlEELGEGAFGKVYKGELLGPSSEesaisVAIKTLKENASPKtQQDFRREAELMSDLQHPNIVCLLGVCTKEQPQCMLF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSL----------TDVVTETCMDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
Cdd:cd05048   88 EYMAHGDLheflvrhsphSDVGVSSDDDGTASSLDQSDFLHiaiqiaaGMEYLSSHHYVHRDLAARNCLVGDGLTVKISD 167
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 421 FGFCAQITPE-----QSKRSTMVgtpYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05048  168 FGLSRDIYSSdyyrvQSKSLLPV---RWMPPEAILYGKFTTESDVWSFGVVLWEIFSyGLQPY 227
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
287-532 2.56e-15

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 76.55  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldiATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14152    6 ELIGQGRWGKVHRG---RWHGEVAIRllEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCKGRT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGmDGSVKLTDFG-FCAQITPEQSKRSTMVGTP 441
Cdd:cd14152   83 LYSFVrdPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYD-NGKVVITDFGlFGISGVVQEGRRENELKLP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 442 ----YWMAPEVVTRKAYGPK---------VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSAVF 507
Cdd:cd14152  162 hdwlCYLAPEIVREMTPGKDedclpfskaADVYAFGTIWYELQARDWPLKNQPAEALIWQIGSgEGMKQVLTTISLGKEV 241
                        250       260
                 ....*....|....*....|....*
gi 578838380 508 RDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14152  242 TEILSACWAFDLEERPSFTLLMDML 266
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
287-477 3.09e-15

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 75.40  E-value: 3.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATgQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd05034    1 KKLGAGQFGEVWMGVWNGT-TKVAVKTLK-PGTMSPEAFLQEAQIMKKLRHDKLVQLYAVCSDEEPIYIVTELMSKGSLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTEtcmDEG-------------QIAavcreclQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSK 433
Cdd:cd05034   79 DYLRT---GEGralrlpqlidmaaQIA-------SGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLI--EDDE 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578838380 434 RSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPY 477
Cdd:cd05034  147 YTAREGAKFpikWTAPEAALYGRFTIKSDVWSFGILLYEIVtYGRVPY 194
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
287-477 3.22e-15

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 76.32  E-value: 3.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALdiATGQEVAIKQMNL--QQQPKKEL-IINEILVMRENknpnIVNYLDSYLVG----DELWVVMEY 359
Cdd:cd14142   11 ECIGKGRYGEVWRGQ--WQGESVAVKIFSSrdEKSWFRETeIYNTVLLRHEN----ILGFIASDMTSrnscTQLWLITHY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHS----NQ----VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 431
Cdd:cd14142   85 HENGSLYDYLQRTTLDHQEMLRLALSAASGLVHLHTeifgTQgkpaIAHRDLKSKNILVKSNGQCCIADLGLAVTHSQET 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 432 SK----RSTMVGTPYWMAPEVVTR-------KAYgPKVDIWSLGIMAIE---------MVEG-EPPY 477
Cdd:cd14142  165 NQldvgNNPRVGTKRYMAPEVLDEtintdcfESY-KRVDIYAFGLVLWEvarrcvsggIVEEyKPPF 230
PK_NRBP1_like cd13984
Pseudokinase domain of Nuclear Receptor Binding Protein 1 and similar proteins; The ...
297-529 3.65e-15

Pseudokinase domain of Nuclear Receptor Binding Protein 1 and similar proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. This subfamily is composed of NRBP1, also called MLF1-adaptor molecule (MADM), and MADML. NRBP1 was originally named based on the presence of nuclear binding and localization motifs prior to functional analyses. It is expressed ubiquitously and is found to localize in the cytoplasm, not the nucleus. NRBP1 is an adaptor protein that interacts with myeloid leukemia factor 1 (MLF1), an oncogene that enhances myeloid development of hematopoietic cells. It also interacts with the small GTPase Rac3. NRBP1 may also be involved in Golgi to ER trafficking. MADML (for MADM-Like) has been shown to be expressed throughout development in Xenopus laevis with highest expression found in the developing lens and retina. The NRBP1-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270886 [Multi-domain]  Cd Length: 256  Bit Score: 75.65  E-value: 3.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 297 VYTALDIATGQEVA--------IKQMNLQQQPKKELIINEILVmrenKNPNIVNY----LDSYLVGDELWVVMEYLAGGS 364
Cdd:cd13984   10 AYLAMDTEEGVEVVwnevqfseRKIFKAQEEKIRAVFDNLIQL----DHPNIVKFhrywTDVQEEKARVIFITEYMSSGS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTET-----CMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLtdfgfcAQITPEQSKRSTM 437
Cdd:cd13984   86 LKQFLKKTkknhkTMNEKSWKRWCTQILSALSYLHSCDppIIHGNLTCDTIFIQHNGLIKI------GSVAPDAIHNHVK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 V-----GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLN-ENPLRALYLiatngtpeLQNPERlsa 505
Cdd:cd13984  160 TcreehRNLHFFAPEYGYLEDVTTAVDIYSFGMCALEMAaleiqsNGEKVSANeEAIIRAIFS--------LEDPLQ--- 228
                        250       260
                 ....*....|....*....|....
gi 578838380 506 vfRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd13984  229 --KDFIRKCLSVAPQDRPSARDLL 250
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
285-528 4.16e-15

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 76.26  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEKIGQGASGTVYTALDIATGQEV----AIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLvGDELWVVMEY 359
Cdd:cd05110   11 RVKVLGSGAFGTVYKGIWVPEGETVkipvAIKILNETTGPKANVeFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEGQ--IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 437
Cdd:cd05110   90 MPHGCLLDYVHEHKDNIGSqlLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTP--YWMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYlNENPLRALYLIATNGTPELQNPERLSAVFRdFLNRC 514
Cdd:cd05110  170 GGKMpiKWMALECIHYRKFTHQSDVWSYGVTIWElMTFGGKPY-DGIPTREIPDLLEKGERLPQPPICTIDVYM-VMVKC 247
                        250
                 ....*....|....
gi 578838380 515 LEMDVDRRGSAKEL 528
Cdd:cd05110  248 WMIDADSRPKFKEL 261
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
284-532 4.22e-15

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 75.28  E-value: 4.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKIGQGASGTVYTALDIATGQeVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG 363
Cdd:cd05114    7 TFMKELGSGLFGVVRLGKWRAQYK-VAIKAIR-EGAMSEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMENG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTEtcmDEGQIA-----AVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 438
Cdd:cd05114   85 CLLNYLRQ---RRGKLSrdmllSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSSGA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 439 GTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEM-VEGEPPYLNENPLRALYLIaTNGTpELQNPERLSAVFRDFLNRCLE 516
Cdd:cd05114  162 KFPVkWSPPEVFNYSKFSSKSDVWSFGVLMWEVfTEGKMPFESKSNYEVVEMV-SRGH-RLYRPKLASKSVYEVMYSCWH 239
                        250
                 ....*....|....*.
gi 578838380 517 MDVDRRGSAKELLQVL 532
Cdd:cd05114  240 EKPEGRPTFADLLRTI 255
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
279-477 4.25e-15

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 75.89  E-value: 4.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIA-TGQ----EVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDE 352
Cdd:cd05036    4 PRKNLTLIRALGQGAFGEVYEGTVSGmPGDpsplQVAVKTLPELCSEQDEMdFLMEALIMSKFNHPNIVRCIGVCFQRLP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTE-----------TCMDEGQIAavcRECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKL 418
Cdd:cd05036   84 RFILLELMAGGDLKSFLREnrprpeqpsslTMLDLLQLA---QDVAKGCRYLEENHFIHRDIAARNCLLTCKGPgrvAKI 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 419 TDFGFCAQITPEQSKRS---TMVGTPyWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05036  161 GDFGMARDIYRADYYRKggkAMLPVK-WMPPEAFLDGIFTSKTDVWSFGVLLWEIFSlGYMPY 222
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
289-503 4.35e-15

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 75.77  E-value: 4.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTV-YTALdiATGQEVAIKQMNLQQQPKKELIIN---------------------EILVMRENKNPNIVnylds 346
Cdd:cd14067    1 LGQGGSGTViYRAR--YQGQPVAVKRFHIKKCKKRTDGSAdtmlkhlraadamknfsefrqEASMLHSLQHPCIV----- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 347 YLVG---DELWVVMEYLAGGSLTDVVTETCMDEGQIA-------AVCRECLQALDFLHSNQVIHRDIKSDNILL-GMDG- 414
Cdd:cd14067   74 YLIGisiHPLCFALELAPLGSLNTVLEENHKGSSFMPlghmltfKIAYQIAAGLAYLHKKNIIFCDLKSDNILVwSLDVq 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 415 ---SVKLTDFGFCAQITPEQSkrSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT 491
Cdd:cd14067  154 ehiNIKLSDYGISRQSFHEGA--LGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPSLGHHQLQIAKKLSK 231
                        250
                 ....*....|..
gi 578838380 492 NGTPELQNPERL 503
Cdd:cd14067  232 GIRPVLGQPEEV 243
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
279-477 5.33e-15

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 75.82  E-value: 5.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQE-------VAIKQMNlQQQPKKEL--IINEILVMRE-NKNPNIVNYLDSYL 348
Cdd:cd05098   11 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDkpnrvtkVAVKMLK-SDATEKDLsdLISEMEMMKMiGKHKNIINLLGACT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 349 VGDELWVVMEYLAGGSL-----------------TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Cdd:cd05098   90 QDGPLYVIVEYASKGNLreylqarrppgmeycynPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 412 MDGSVKLTDFGFCAQITP-EQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05098  170 EDNVMKIADFGLARDIHHiDYYKKTTNGRLPVkWMAPEALFDRIYTHQSDVWSFGVLLWEIFTlGGSPY 238
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
287-482 6.03e-15

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 75.49  E-value: 6.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTA-LDIATG---QEVAIKQMNLQQQP--KKEliiNEILVMRENKNPNIVNYLDSYLVGDEL----WVV 356
Cdd:cd14055    1 KLVGKGRFAEVWKAkLKQNASgqyETVAVKIFPYEEYAswKNE---KDIFTDASLKHENILQFLTAEERGVGLdrqyWLI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ---------VIHRDIKSDNILLGMDGSVKLTDFGFC--- 424
Cdd:cd14055   78 TAYHENGSLQDYLTRHILSWEDLCKMAGSLARGLAHLHSDRtpcgrpkipIAHRDLKSSNILVKNDGTCVLADFGLAlrl 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578838380 425 -AQITPEQSKRSTMVGTPYWMAPEVVTRKA------YGPKVDIWSLGIMAIEMV----------EGEPPY---LNENP 482
Cdd:cd14055  158 dPSLSVDELANSGQVGTARYMAPEALESRVnledleSFKQIDVYSMALVLWEMAsrceasgevkPYELPFgskVRERP 235
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
283-482 6.76e-15

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 76.45  E-value: 6.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKqmnLQQQPKKeLIinEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAg 362
Cdd:PHA03209  68 YTVIKTLTPGSEGRVFVATKPGQPDPVVLK---IGQKGTT-LI--EAMLLQNVNHPSVIRMKDTLVSGAITCMVLPHYS- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 gslTDVVTETCMDEGQIA---AVC--RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfCAQITPEQSKRSTM 437
Cdd:PHA03209 141 ---SDLYTYLTKRSRPLPidqALIieKQILEGLRYLHAQRIIHRDVKTENIFINDVDQVCIGDLG-AAQFPVVAPAFLGL 216
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVeGEPPYLNENP 482
Cdd:PHA03209 217 AGTVETNAPEVLARDKYNSKADIWSAGIVLFEML-AYPSTIFEDP 260
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
282-496 6.84e-15

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 75.87  E-value: 6.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDsylvgdelwvVMEY 359
Cdd:cd07858    6 KYVPIKPIGRGAYGIVCSAKNSETNEKVAIKKIAnaFDNRIDAKRTLREIKLLRHLDHENVIAIKD----------IMPP 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDV--VTETcMDEG--QIAAV--------CR----ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGF 423
Cdd:cd07858   76 PHREAFNDVyiVYEL-MDTDlhQIIRSsqtlsddhCQyflyQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 424 cAQITPEQSKRST-MVGTPYWMAPEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPE 496
Cdd:cd07858  155 -ARTTSEKGDFMTeYVVTRWYRAPELLLNCSeYTTAIDVWSVGCIFAELLGRKPLFPGKDYVHQLKLItELLGSPS 229
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
279-477 6.90e-15

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 74.92  E-value: 6.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALdIATGQEVAIKQMNlQQQPKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVME 358
Cdd:cd05067    5 PRETLKLVERLGAGQFGEVWMGY-YNGHTKVAIKSLK-QGSMSPDAFLAEANLMKQLQHQRLVR-LYAVVTQEPIYIITE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTEtcmDEG------QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQS 432
Cdd:cd05067   82 YMENGSLVDFLKT---PSGikltinKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDN 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 433 KRSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05067  157 EYTAREGAKFpikWTAPEAINYGTFTIKSDVWSFGILLTEIVThGRIPY 205
PKc_DYRK2_3 cd14224
Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and ...
282-481 7.65e-15

Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of DYRK2 and DYRK3, and similar proteins. Drosophila DYRK2 interacts and phosphorylates the chromatin remodelling factor, SNR1 (Snf5-related 1), and also interacts with the essential chromatin component, trithorax. It may play a role in chromatin remodelling. Vertebrate DYRK2 phosphorylates and regulates the tumor suppressor p53 to induce apoptosis in response to DNA damage. It can also phosphorylate the transcription factor, nuclear factor of activated T cells (NFAT). DYRK2 is overexpressed in lung adenocarcinoma and esophageal carcinomas, and is a predictor for favorable prognosis in lung adenocarcinoma. DYRK3, also called regulatory erythroid kinase (REDK), is highly expressed in erythroid cells and the testis, and is also present in adult kidney and liver. It promotes cell survival by phosphorylating and activating SIRT1, an NAD(+)-dependent protein deacetylase, which promotes p53 deacetylation, resulting in the inhibition of apoptosis. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other S/T kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271126 [Multi-domain]  Cd Length: 380  Bit Score: 76.32  E-value: 7.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIK----QMNLQQQPKKELIINEILVMRENKNP-NIVNYLDSYLVGDELWVV 356
Cdd:cd14224   66 RYEVLKVIGKGSFGQVVKAYDHKTHQHVALKmvrnEKRFHRQAAEEIRILEHLKKQDKDNTmNVIHMLESFTFRNHICMT 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGgSLTDVVTETCMDEGQIAAV---CRECLQALDFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFG-FCAqitpE 430
Cdd:cd14224  146 FELLSM-NLYELIKKNKFQGFSLQLVrkfAHSILQCLDALHRNKIIHCDLKPENILLKQQGrsGIKVIDFGsSCY----E 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 431 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:cd14224  221 HQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGED 271
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
287-477 8.33e-15

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 74.27  E-value: 8.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAlDIATGQEVAIK--QMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05085    2 ELLGKGNFGEVYKG-TLKDKTPVAVKtcKEDLPQELKIKFL-SEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVVTETcMDEGQIAAVCRECLQA---LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441
Cdd:cd05085   80 FLSFLRKK-KDELKTKQLVKFSLDAaagMAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQIP 158
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578838380 442 Y-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05085  159 IkWTAPEALNYGRYSSESDVWSFGILLWETFSlGVCPY 196
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
279-477 9.27e-15

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 74.37  E-value: 9.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATgQEVAIKQMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 358
Cdd:cd05068    6 DRKSLKLLRKLGSGQFGEVWEGLWNNT-TPVAVKTLKPGTMDPEDFL-REAQIMKKLRHPKLIQLYAVCTLEEPIYIITE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVT--------ETCMD-EGQIAAvcreclqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITP 429
Cdd:cd05068   84 LMKHGSLLEYLQgkgrslqlPQLIDmAAQVAS-------GMAYLESQNYIHRDLAARNVLVGENNICKVADFGL-ARVIK 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 430 EQSKRSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05068  156 VEDEYEAREGAKFpikWTAPEAANYNRFSIKSDVWSFGILLTEIVTyGRIPY 207
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
280-471 1.05e-14

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 74.58  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 280 KKKYTRFEKIGQGASGTV----YTALDIATGQEVAIKqmNLQQQPKKELIIN---EILVMRENKNPNIVNY--LDSYLVG 350
Cdd:cd05079    3 KRFLKRIRDLGEGHFGKVelcrYDPEGDNTGEQVAVK--SLKPESGGNHIADlkkEIEILRNLYHENIVKYkgICTEDGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 428
Cdd:cd05079   81 NGIKLIMEFLPSGSLKEYLprNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578838380 429 PEQSKRSTM--VGTP-YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV 471
Cdd:cd05079  161 TDKEYYTVKddLDSPvFWYAPECLIQSKFYIASDVWSFGVTLYELL 206
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
279-477 1.18e-14

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 75.05  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQE-------VAIKQMNlQQQPKKEL--IINEILVMRE-NKNPNIVNYLDSYL 348
Cdd:cd05101   22 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDkpkeavtVAVKMLK-DDATEKDLsdLVSEMEMMKMiGKHKNIINLLGACT 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 349 VGDELWVVMEYLAGGSLTDV-----------------VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Cdd:cd05101  101 QDGPLYVIVEYASKGNLREYlrarrppgmeysydinrVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 180
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 412 MDGSVKLTDFGFCAQITP-EQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05101  181 ENNVMKIADFGLARDINNiDYYKKTTNGRLPVkWMAPEALFDRVYTHQSDVWSFGVLMWEIFTlGGSPY 249
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
289-488 1.21e-14

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 74.86  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATgqEVAIKQM----NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14159    1 IGEGGFGCVYQAVMRNT--EYAVKRLkedsELDWSVVKNSFLTEVEKLSRFRHPNIVDLAGYSAQQGNYCLIYVYLPNGS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTD----VVTETCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFG---FCAQI-TPEQS-- 432
Cdd:cd14159   79 LEDrlhcQVSCPCLSWSQRLHVLLGTARAIQYLHSDSpsLIHGDVKSSNILLDAALNPKLGDFGlarFSRRPkQPGMSst 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578838380 433 --KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL 488
Cdd:cd14159  159 laRTQTVRGTLAYLPEEYVKTGTLSVEIDVYSFGVVLLELLTGRRAMEVDSCSPTKYL 216
STKc_Unc-89_rpt2 cd14112
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated ...
279-480 1.32e-14

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271014 [Multi-domain]  Cd Length: 259  Bit Score: 74.10  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIA--TGQEVAIKQMNLQQQpkKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd14112    1 PTGRFSFGSEIFRGRFSVIVKAVDSTteTDAHCAVKIFEVSDE--ASEAVREFESLRTLQHENVQRLIAAFKPSNFAYLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKR 434
Cdd:cd14112   79 MEKLQEDVFTRFSSNDYYSEEQVATTVRQILDALHYLHFKGIAHLDVQPDNIMFQSVRSwqVKLVDFGRAQKVSKLGKVP 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 435 STmvGTPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
Cdd:cd14112  159 VD--GDTDWASPEFHnPETPITVQSDIWGLGVLTFCLLSGFHPFTSE 203
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
278-477 1.45e-14

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 75.06  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 278 DPKKKYTRF-----EKIGQGASGTVYTALDIATGQE-------VAIKQMNlQQQPKKEL--IINEILVMRE-NKNPNIVN 342
Cdd:cd05100    4 DPKWELSRTrltlgKPLGEGCFGQVVMAEAIGIDKDkpnkpvtVAVKMLK-DDATDKDLsdLVSEMEMMKMiGKHKNIIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 343 YLDSYLVGDELWVVMEYLAGGSL-----------TDVVTETC-MDEGQIA-----AVCRECLQALDFLHSNQVIHRDIKS 405
Cdd:cd05100   83 LLGACTQDGPLYVLVEYASKGNLreylrarrppgMDYSFDTCkLPEEQLTfkdlvSCAYQVARGMEYLASQKCIHRDLAA 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578838380 406 DNILLGMDGSVKLTDFGFCAQI-TPEQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05100  163 RNVLVTEDNVMKIADFGLARDVhNIDYYKKTTNGRLPVkWMAPEALFDRVYTHQSDVWSFGVLLWEIFTlGGSPY 237
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
323-527 1.57e-14

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 74.07  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 323 ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 402
Cdd:cd14027   36 EALLEEGKMMNRLRHSRVVKLLGVILEEGKYSLVMEYMEKGNLMHVLKKVSVPLSVKGRIILEIIEGMAYLHGKGVIHKD 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 403 IKSDNILLGMDGSVKLTDFGFC-----AQITPEQSKRSTMV--------GTPYWMAPEVVTRKAYGP--KVDIWSLGIMA 467
Cdd:cd14027  116 LKPENILVDNDFHIKIADLGLAsfkmwSKLTKEEHNEQREVdgtakknaGTLYYMAPEHLNDVNAKPteKSDVYSFAIVL 195
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 468 IEMVEGEPPYLNENPLRALYLIATNGT-PELQN-PERLSAVFRDFLNRCLEMDVDRRGSAKE 527
Cdd:cd14027  196 WAIFANKEPYENAINEDQIIMCIKSGNrPDVDDiTEYCPREIIDLMKLCWEANPEARPTFPG 257
PTKc_Wee1b cd14139
Catalytic domain of the Protein Tyrosine Kinase, Wee1b; PTKs catalyze the transfer of the ...
282-528 2.01e-14

Catalytic domain of the Protein Tyrosine Kinase, Wee1b; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of human Wee1b (also called Wee2), Xenopus laevis Wee1a (XeWee1a) and similar vertebrate proteins. XeWee1a accumulates after exiting the metaphase II stage in oocytes and in early mitotic cells. It functions during the first zygotic cell division and not during subsequent divisions. Mammalian Wee2/Wee1b is an oocyte-specific inhibitor of meiosis that functions downstream of cAMP. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The Wee1b subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271041 [Multi-domain]  Cd Length: 274  Bit Score: 73.81  E-value: 2.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQmnlQQQPKKELIiNEILVMRE-------NKNPNIVNYLDSYLVGDELW 354
Cdd:cd14139    1 EFLELEKIGVGEFGSVYKCIKRLDGCVYAIKR---SMRPFAGSS-NEQLALHEvyahavlGHHPHVVRYYSAWAEDDHMI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL----LGMDGSV--------- 416
Cdd:cd14139   77 IQNEYCNGGSLQDAISENTksgnhFEEPELKDILLQVSMGLKYIHNSGLVHLDIKPSNIFichkMQSSSGVgeevsneed 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 417 ---------KLTDFGFCAQITPEQSKRstmvGTPYWMAPEVVTRK-AYGPKVDIWSLGiMAIEMVEGEPPyLNENPlRAL 486
Cdd:cd14139  157 eflsanvvyKIGDLGHVTSINKPQVEE----GDSRFLANEILQEDyRHLPKADIFALG-LTVALAAGAEP-LPTNG-AAW 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 578838380 487 YLIATNGTPELqnPERLSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd14139  230 HHIRKGNFPDV--PQELPESFSSLLKNMIQPDPEQRPSATAL 269
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
279-477 2.69e-14

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 73.85  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALDIATGQE-------VAIKQMNlQQQPKKEL--IINEILVMR-ENKNPNIVNYLDSYL 348
Cdd:cd05099   10 PRDRLVLGKPLGEGCFGQVVRAEAYGIDKSrpdqtvtVAVKMLK-DNATDKDLadLISEMELMKlIGKHKNIINLLGVCT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 349 VGDELWVVMEYLAGGSLTDVVTE------------TCMDEGQIA-----AVCRECLQALDFLHSNQVIHRDIKSDNILLG 411
Cdd:cd05099   89 QEGPLYVIVEYAAKGNLREFLRArrppgpdytfdiTKVPEEQLSfkdlvSCAYQVARGMEYLESRRCIHRDLAARNVLVT 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 412 MDGSVKLTDFGFCAQITP-EQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05099  169 EDNVMKIADFGLARGVHDiDYYKKTSNGRLPVkWMAPEALFDRVYTHQSDVWSFGILMWEIFTlGGSPY 237
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
288-528 3.27e-14

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 73.46  E-value: 3.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 366
Cdd:cd05045   12 EFGKVVKATAFRLKGRAGYTTVAVKMLKENASSSELRdLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 367 DVVTET-------------------------CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd05045   92 SFLRESrkvgpsylgsdgnrnssyldnpderALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQS--KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNgtPELQ 498
Cdd:cd05045  172 GLSRDVYEEDSyvKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTlGGNPYPGIAPERLFNLLKTG--YRME 249
                        250       260       270
                 ....*....|....*....|....*....|
gi 578838380 499 NPERLSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd05045  250 RPENCSEEMYNLMLTCWKQEPDKRPTFADI 279
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
288-477 3.30e-14

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 72.84  E-value: 3.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd05052   13 KLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFL-KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMPYGNLLD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTETcmDEGQIAAV-----CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY 442
Cdd:cd05052   92 YLREC--NREELNAVvllymATQIASAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPI 169
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578838380 443 -WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05052  170 kWTAPESLAYNKFSIKSDVWAFGVLLWEIATyGMSPY 206
PTKc_IGF-1R cd05062
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs ...
279-529 4.45e-14

Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. IGF-1R is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the ligand (IGF-1 or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, which stimulates downstream kinase activities and biological function. IGF-1R signaling is important in the differentiation, growth, and survival of normal cells. In cancer cells, where it is frequently overexpressed, IGF-1R is implicated in proliferation, the suppression of apoptosis, invasion, and metastasis. IGF-1R is being developed as a therapeutic target in cancer treatment. The IGF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133193 [Multi-domain]  Cd Length: 277  Bit Score: 72.76  E-value: 4.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTAldIATG-------QEVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVG 350
Cdd:cd05062    4 AREKITMSRELGQGSFGMVYEG--IAKGvvkdepeTRVAIKTVNEAASMRERIeFLNEASVMKEFNCHHVVRLLGVVSQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 351 DELWVVMEYLAGGSLTDVV----TETCMDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 419
Cdd:cd05062   82 QPTLVIMELMTRGDLKSYLrslrPEMENNPVQAPPSLKKMIQmageiadGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 420 DFGFCAQITPEQSKRSTMVG--TPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTpe 496
Cdd:cd05062  162 DFGMTRDIYETDYYRKGGKGllPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATlAEQPYQGMSNEQVLRFVMEGGL-- 239
                        250       260       270
                 ....*....|....*....|....*....|...
gi 578838380 497 LQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 529
Cdd:cd05062  240 LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEII 272
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
281-528 6.70e-14

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 72.40  E-value: 6.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN-------EILVMRENKNPNIVNYLDSY-LVGDE 352
Cdd:cd14040    6 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENyhkhacrEYRIHKELDHPRIVKLYDYFsLDTDT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILLgMDGS----VKLTDFGFcA 425
Cdd:cd14040   86 FCTVLEYCEGNDLDFYLKQhKLMSEKEARSIVMQIVNALRYLNEIKppIIHYDLKPGNILL-VDGTacgeIKITDFGL-S 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 426 QITPEQSK-------RSTMVGTPYWMAPEVVTRKAYGPK----VDIWSLGIMAIEMVEGEPPY---------LNENPLra 485
Cdd:cd14040  164 KIMDDDSYgvdgmdlTSQGAGTYWYLPPECFVVGKEPPKisnkVDVWSVGVIFFQCLYGRKPFghnqsqqdiLQENTI-- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 578838380 486 lyLIATngtpELQNPER--LSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd14040  242 --LKAT----EVQFPVKpvVSNEAKAFIRRCLAYRKEDRFDVHQL 280
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
378-481 8.69e-14

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 73.96  E-value: 8.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 378 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGfcaQITPEQSKRSTM----VGTPYWMAPEVVTRKA 453
Cdd:PHA03210 268 QTRAIMKQLLCAVEYIHDKKLIHRDIKLENIFLNCDGKIVLGDFG---TAMPFEKEREAFdygwVGTVATNSPEILAGDG 344
                         90       100
                 ....*....|....*....|....*...
gi 578838380 454 YGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Cdd:PHA03210 345 YCEITDIWSCGLILLDMLSHDFCPIGDG 372
PTKc_Wee1a cd14138
Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the ...
282-530 8.88e-14

Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of human Wee1a, Xenopus laevis Wee1b (XeWee1b) and similar vertebrate proteins. Members of this subfamily show a wide expression pattern. XeWee1b functions after the first zygotic cell divisions. It is expressed in all tissues and is also present after the gastrulation stage of embryos. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The Wee1a subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271040 [Multi-domain]  Cd Length: 276  Bit Score: 71.98  E-value: 8.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQmnlqqqPKKELI--INEILVMRE-------NKNPNIVNYLDSYLVGDE 352
Cdd:cd14138    6 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR------SKKPLAgsVDEQNALREvyahavlGQHSHVVRYYSAWAEDDH 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM--------------- 412
Cdd:cd14138   80 MLIQNEYCNGGSLADAISENyrimsYFTEPELKDLLLQVARGLKYIHSMSLVHMDIKPSNIFISRtsipnaaseegdede 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 413 --DGSV--KLTDFGFCAQITPEQSKRstmvGTPYWMAPEVVTRK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENplrALY 487
Cdd:cd14138  160 waSNKVifKIGDLGHVTRVSSPQVEE----GDSRFLANEVLQENyTHLPKADIFALALTVVCAAGAEPLPTNGD---QWH 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 578838380 488 LIATNGTPELqnPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14138  233 EIRQGKLPRI--PQVLSQEFLDLLKVMIHPDPERRPSAVALVK 273
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
388-532 1.28e-13

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 72.32  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGI 465
Cdd:cd05102  183 RGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIykDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGV 262
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 466 MAIEMVE-GEPPY----LNENPLRALyliaTNGTpELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05102  263 LLWEIFSlGASPYpgvqINEEFCQRL----KDGT-RMRAPEYATPEIYRIMLSCWHGDPKERPTFSDLVEIL 329
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
288-483 1.31e-13

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 71.35  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALdiATGQEVAIKQMNLQQQPK--KELIINEILVMRENknpNIVNYLDSYLVGD----ELWVVMEYLA 361
Cdd:cd14144    2 SVGKGRYGEVWKGK--WRGEKVAVKIFFTTEEASwfRETEIYQTVLMRHE---NILGFIAADIKGTgswtQLYLITDYHE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN--------QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
Cdd:cd14144   77 NGSLYDFLRGNTLDTQSMLKLAYSAACGLAHLHTEifgtqgkpAIAHRDIKSKNILVKKNGTCCIADLGLAVKFISETNE 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 434 ----RSTMVGTPYWMAPEVVT----RKAYGP--KVDIWSLGIMAIEMV----------EGEPPYLNENPL 483
Cdd:cd14144  157 vdlpPNTRVGTKRYMAPEVLDeslnRNHFDAykMADMYSFGLVLWEIArrcisggiveEYQLPYYDAVPS 226
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
374-469 1.35e-13

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 73.00  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 374 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpeQSKRST-----MVGTPYWMAPEV 448
Cdd:PHA03211 257 LGLAQVTAVARQLLSAIDYIHGEGIIHRDIKTENVLVNGPEDICLGDFGAACFA---RGSWSTpfhygIAGTVDTNAPEV 333
                         90       100
                 ....*....|....*....|.
gi 578838380 449 VTRKAYGPKVDIWSLGIMAIE 469
Cdd:PHA03211 334 LAGDPYTPSVDIWSAGLVIFE 354
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
288-522 1.36e-13

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 71.26  E-value: 1.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATgQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd05069   19 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEFMGKGSLLD 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRSTMVGTPY-- 442
Cdd:cd05069   96 FLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI--EDNEYTARQGAKFpi 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 443 -WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPY---LNENPL----RALYLIATNGTPElqnperlsaVFRDFLNR 513
Cdd:cd05069  174 kWTAPEAALYGRFTIKSDVWSFGILLTELVtKGRVPYpgmVNREVLeqveRGYRMPCPQGCPE---------SLHELMKL 244

                 ....*....
gi 578838380 514 CLEMDVDRR 522
Cdd:cd05069  245 CWKKDPDER 253
PKc_YAK1 cd14212
Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze ...
283-475 1.40e-13

Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of proteins with similarity to Saccharomyces cerevisiae YAK1 (or Yak1p), a dual-specificity kinase that autophosphorylates at tyrosine residues and phosphorylates substrates on S/T residues. YAK1 phosphorylates and activates the transcription factors Hsf1 and Msn2, which play important roles in cellular homeostasis during stress conditions including heat shock, oxidative stress, and nutrient deficiency. It also phosphorylates the protein POP2, a component of a complex that regulates transcription, under glucose-deprived conditions. It functions as a part of a glucose-sensing system that is involved in controlling growth in yeast. The YAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271114 [Multi-domain]  Cd Length: 330  Bit Score: 71.90  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 283 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ----QQPKKELIINEILVM---RENKNpNIVNYLDSYLVGDELWV 355
Cdd:cd14212    1 YLVLDLLGQGTFGQVVKCQDLKTNKLVAVKVLKNKpayfRQAMLEIAILTLLNTkydPEDKH-HIVRLLDHFMHHGHLCI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLA-------------GGSLTDVVTETcmdeGQIaavcrecLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTD 420
Cdd:cd14212   80 VFELLGvnlyellkqnqfrGLSLQLIRKFL----QQL-------LDALSVLKDARIIHCDLKPENILLVNLDSpeIKLID 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578838380 421 FG-FCAqitpEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd14212  149 FGsACF----ENYTLYTYIQSRFYRSPEVLLGLPYSTAIDMWSLGCIAAELFLGLP 200
PKc_DYRK1 cd14226
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
281-475 1.50e-13

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. Mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A was previously called minibrain kinase homolog (MNBH) or dual-specificity YAK1-related kinase. It phosphorylates various substrates and is involved in many cellular events. It phosphorylates and inhibits the transcription factors, nuclear factor of activated T cells (NFAT) and forkhead in rhabdomyosarcoma (FKHR). It regulates neuronal differentiation by targetting CREB (cAMP response element-binding protein). It also targets many endocytic proteins including dynamin and amphiphysin and may play a role in the endocytic pathway. The gene encoding DYRK1A is located in the DSCR (Down syndrome critical region) of human chromosome 21 and DYRK1A has been implicated in the pathogenesis of DS. DYRK1B, also called minibrain-related kinase (MIRK), is highly expressed in muscle and plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271128 [Multi-domain]  Cd Length: 339  Bit Score: 71.97  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 281 KKYTRFEKIGQGASGTVYTALDIATGQEVAIK----QMNLQQQPKKELIINEILVMR--ENKNpNIVNYLDSYLVGDELW 354
Cdd:cd14226   13 DRYEIDSLIGKGSFGQVVKAYDHVEQEWVAIKiiknKKAFLNQAQIEVRLLELMNKHdtENKY-YIVRLKRHFMFRNHLC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 355 VVMEYLAGgSLTDVVTETCMDEGQIAAVCR---ECLQALDFLHSN--QVIHRDIKSDNILL--GMDGSVKLTDFGFCAQI 427
Cdd:cd14226   92 LVFELLSY-NLYDLLRNTNFRGVSLNLTRKfaqQLCTALLFLSTPelSIIHCDLKPENILLcnPKRSAIKIIDFGSSCQL 170
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 428 TPE-----QSKrstmvgtpYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 475
Cdd:cd14226  171 GQRiyqyiQSR--------FYRSPEVLLGLPYDLAIDMWSLGCILVEMHTGEP 215
PTKc_Wee1 cd14051
Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the ...
287-530 1.77e-13

Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Wee1 is a nuclear cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. There are two distinct Wee1 proteins in vertebrates showing different expression patterns, called Wee1a and Wee1b. They are functionally dstinct and are implicated in different steps of egg maturation and embryo development. The Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270953 [Multi-domain]  Cd Length: 275  Bit Score: 70.90  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTALDIATGQEVAIKQmnlQQQPKKELIiNEILVMRE-------NKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd14051    6 EKIGSGEFGSVYKCINRLDGCVYAIKK---SKKPVAGSV-DEQNALNEvyahavlGKHPHVVRYYSAWAEDDHMIIQNEY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETC-----MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 434
Cdd:cd14051   82 CNGGSLADAISENEkagerFSEAELKDLLLQVAQGLKYIHSQNLVHMDIKPGNIFISRTPNPVSSEEEEEDFEGEEDNPE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 435 STMV--------------------GTPYWMAPEVVtRKAYG--PKVDIWSLGIMAIEMVEGEPpyLNENPlRALYLIATN 492
Cdd:cd14051  162 SNEVtykigdlghvtsisnpqveeGDCRFLANEIL-QENYShlPKADIFALALTVYEAAGGGP--LPKNG-DEWHEIRQG 237
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 578838380 493 GTPELQNperLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
Cdd:cd14051  238 NLPPLPQ---CSPEFNELLRSMIHPDPEKRPSAAALLQ 272
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
288-522 1.80e-13

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 70.76  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTV----YTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLdSYLVGDELWVVMEYLAGG 363
Cdd:cd05116    2 ELGSGNFGTVkkgyYQMKKVVKTVAVKILKNEANDPALKDELLREANVMQQLDNPYIVRMI-GICEAESWMLVMEMAELG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS--KRSTMVGT 440
Cdd:cd05116   81 PLNKFLQKNrHVTEKNITELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENyyKAQTHGKW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 441 PY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIaTNGTpELQNPERLSAVFRDFLNRCLEMD 518
Cdd:cd05116  161 PVkWYAPECMNYYKFSSKSDVWSFGVLMWEAFSyGQKPYKGMKGNEVTQMI-EKGE-RMECPAGCPPEMYDLMKLCWTYD 238

                 ....
gi 578838380 519 VDRR 522
Cdd:cd05116  239 VDER 242
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
288-533 1.95e-13

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 70.33  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATgQEVAIKQMnlqqQP---KKELIINEILVMRENKNPNIVNYldsYLVGDE--LWVVMEYLAG 362
Cdd:cd14203    2 KLGQGCFGEVWMGTWNGT-TKVAIKTL----KPgtmSPEAFLEEAQIMKKLRHDKLVQL---YAVVSEepIYIVTEFMSK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 363 GSLTDVVTEtcmDEG------QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRST 436
Cdd:cd14203   74 GSLLDFLKD---GEGkylklpQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI--EDNEYTA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPYLNENPLRALYLIATNgtPELQNPERLSAVFRDFLN 512
Cdd:cd14203  149 RQGAKFpikWTAPEAALYGRFTIKSDVWSFGILLTELVtKGRVPYPGMNNREVLEQVERG--YRMPCPPGCPESLHELMC 226
                        250       260
                 ....*....|....*....|.
gi 578838380 513 RCLEMDVDRRGSAkELLQVLL 533
Cdd:cd14203  227 QCWRKDPEERPTF-EYLQSFL 246
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
289-532 2.55e-13

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 70.26  E-value: 2.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTA---LDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDEL------WVVM 357
Cdd:cd05035    7 LGEGEFGSVMEAqlkQDDGSQLKVAVKTMKVDIHTYSEIeeFLSEAACMKDFDHPNVMRLIGVCFTASDLnkppspMVIL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTETCMDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE 430
Cdd:cd05035   87 PFMKHGDLHSYLLYSRLGGLPEKLPLQTLLKfmvdiakGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSRKIYSG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 431 QSKRSTMVGT-PY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLN-ENPLRALYLIatNGTPELQNPERLSAV 506
Cdd:cd05035  167 DYYRQGRISKmPVkWIALESLADNVYTSKSDVWSFGVTMWEiATRGQTPYPGvENHEIYDYLR--NGNRLKQPEDCLDEV 244
                        250       260
                 ....*....|....*....|....*.
gi 578838380 507 FrDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05035  245 Y-FLMYFCWTVDPKDRPTFTKLREVL 269
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
388-532 4.16e-13

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 70.80  E-value: 4.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGI 465
Cdd:cd14207  191 RGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIykNPDYVRKGDARLPLKWMAPESIFDKIYSTKSDVWSYGV 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 466 MAIEMVE-GEPPY----LNENPLRALYLIATNGTPELQNPErlsaVFRDFLNrCLEMDVDRRGSAKELLQVL 532
Cdd:cd14207  271 LLWEIFSlGASPYpgvqIDEDFCSKLKEGIRMRAPEFATSE----IYQIMLD-CWQGDPNERPRFSELVERL 337
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
232-470 4.39e-13

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 71.03  E-value: 4.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 232 NKEVTPPSAENANSSTLYRNTDRQrkkSKMTDEEilEKLRSIVSVGDP----KKKYTRFEKIGQGASGTVY--TALDIAT 305
Cdd:PHA03207  44 DCDELGDSDDVTHATDYDADEESL---SPQTDVC--QEPCETTSSSDPasvvRMQYNILSSLTPGSEGEVFvcTKHGDEQ 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 306 GQEVAIKQMNLQQQPKKEliineILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRE 385
Cdd:PHA03207 119 RKKVIVKAVTGGKTPGRE-----IDILKTISHRAIINLIHAYRWKSTVCMVMPKYKCDLFTYVDRSGPLPLEQAITIQRR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 386 CLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT--PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL 463
Cdd:PHA03207 194 LLEALAYLHGRGIIHRDVKTENIFLDEPENAVLGDFGAACKLDahPDTPQCYGWSGTLETNSPELLALDPYCAKTDIWSA 273

                 ....*..
gi 578838380 464 GIMAIEM 470
Cdd:PHA03207 274 GLVLFEM 280
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
289-477 5.07e-13

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 69.30  E-value: 5.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATG--QEVAIKQMN-LQQQPKKELIINEILVM-RENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd05047    3 IGEGNFGQVLKARIKKDGlrMDAAIKRMKeYASKDDHRDFAGELEVLcKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVV-----------------TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAqi 427
Cdd:cd05047   83 LLDFLrksrvletdpafaiansTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR-- 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578838380 428 TPEQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05047  161 GQEVYVKKTMGRLPVrWMAIESLNYSVYTTNSDVWSYGVLLWEIVSlGGTPY 212
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
288-534 5.16e-13

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 69.61  E-value: 5.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTA--LDIATGQE---VAIKQM-----NLQQQPKKELiinEILVMRENKNpnIVNYLDSYLVGDELWVVM 357
Cdd:cd05092   12 ELGEGAFGKVFLAecHNLLPEQDkmlVAVKALkeateSARQDFQREA---ELLTVLQHQH--IVRFYGVCTEGEPLIMVF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 358 EYLAGGSLTDVVTE-----TCMDEG-----------QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421
Cdd:cd05092   87 EYMRHGDLNRFLRShgpdaKILDGGegqapgqltlgQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 422 GFCAQITPEQSKR---STMVGTpYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIaTNGTpEL 497
Cdd:cd05092  167 GMSRDIYSTDYYRvggRTMLPI-RWMPPESILYRKFTTESDIWSFGVVLWEIFTyGKQPWYQLSNTEAIECI-TQGR-EL 243
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 578838380 498 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd05092  244 ERPRTCPPEVYAIMQGCWQREPQQRHSIKDIHSRLQA 280
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
279-532 5.17e-13

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 69.86  E-value: 5.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVY--TALDIATGQE---VAIKQM--NLQQQPKKELIiNEILVMRENKNPNIVNYLDSYLVGD 351
Cdd:cd05050    3 PRNNIEYVRDIGQGAFGRVFqaRAPGLLPYEPftmVAVKMLkeEASADMQADFQ-REAALMAEFDHPNIVKLLGVCAVGK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQ-------------------ALDFLHSNQVIHRDIKSDNI 408
Cdd:cd05050   82 PMCLLFEYMAYGDLNEFLRHRSpraqCSLSHSTSSARKCGLnplplscteqlciakqvaaGMAYLSERKFVHRDLATRNC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 409 LLGMDGSVKLTDFGFCAQI-TPEQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRA 485
Cdd:cd05050  162 LVGENMVVKIADFGLSRNIySADYYKASENDAIPIrWMPPESIFYNRYTTESDVWAYGVVLWEIFSyGMQPYYGMAHEEV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 578838380 486 LYLIATNGTpeLQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05050  242 IYYVRDGNV--LSCPDNCPLELYNLMRLCWSKLPSDRPSFASINRIL 286
STKc_TLK2 cd14041
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the ...
282-528 5.53e-13

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270943 [Multi-domain]  Cd Length: 309  Bit Score: 70.09  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN-------EILVMRENKNPNIVNYLDSY-LVGDEL 353
Cdd:cd14041    7 RYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENyhkhacrEYRIHKELDHPRIVKLYDYFsLDTDSF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 WVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL---GMDGSVKLTDFGFcAQI 427
Cdd:cd14041   87 CTVLEYCEGNDLDFYLKQhKLMSEKEARSIIMQIVNALKYLNEIKppIIHYDLKPGNILLvngTACGEIKITDFGL-SKI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSK--------RSTMVGTPYWMAPEVVTRKAYGPK----VDIWSLGIMAIEMVEGEPPY---------LNENPLral 486
Cdd:cd14041  166 MDDDSYnsvdgmelTSQGAGTYWYLPPECFVVGKEPPKisnkVDVWSVGVIFYQCLYGRKPFghnqsqqdiLQENTI--- 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 578838380 487 yLIATngtpELQNPER--LSAVFRDFLNRCLEMDVDRRGSAKEL 528
Cdd:cd14041  243 -LKAT----EVQFPPKpvVTPEAKAFIRRCLAYRKEDRIDVQQL 281
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
287-534 7.36e-13

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 68.91  E-value: 7.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTV----YTALDIATGQeVAIK---QMNLQQQPKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVMEY 359
Cdd:cd05040    1 EKLGDGSFGVVrrgeWTTPSGKVIQ-VAVKclkSDVLSQPNAMDDFLKEVNAMHSLDHPNLIR-LYGVVLSSPLMMVTEL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCmDEGQIAAVCRECLQ---ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRST 436
Cdd:cd05040   79 APLGSLLDRLRKDQ-GHFLISTLCDYAVQianGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGL-MRALPQNEDHYV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 M---VGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTpELQNPERLSAVFRDFL 511
Cdd:cd05040  157 MqehRKVPFaWCAPESLKTRKFSHASDVWMFGVTLWEMFTyGEEPWLGLNGSQILEKIDKEGE-RLERPDDCPQDIYNVM 235
                        250       260
                 ....*....|....*....|...
gi 578838380 512 NRCLEMDVDRRGSAKELLQVLLA 534
Cdd:cd05040  236 LQCWAHKPADRPTFVALRDFLPE 258
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
288-477 7.70e-13

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 68.95  E-value: 7.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTALDIATGQeVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVMEYLAGGSLTD 367
Cdd:cd05071   16 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQ-LYAVVSEEPIYIVTEYMSKGSLLD 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 368 VV---TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRSTMVGTPY-- 442
Cdd:cd05071   93 FLkgeMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFpi 170
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578838380 443 -WMAPEVVTRKAYGPKVDIWSLGIMAIEM-VEGEPPY 477
Cdd:cd05071  171 kWTAPEAALYGRFTIKSDVWSFGILLTELtTKGRVPY 207
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
287-532 8.33e-13

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 68.88  E-value: 8.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldiATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGS 364
Cdd:cd14153    6 ELIGKGRFGQVYHG---RWHGEVAIRLIDIERDNEEQLkaFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 365 LTDVV--TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGmDGSVKLTDFGFCA-----QITPEQSKRSTM 437
Cdd:cd14153   83 LYSVVrdAKVVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFTisgvlQAGRREDKLRIQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 438 VGTPYWMAPEVVTRKA---------YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFR 508
Cdd:cd14153  162 SGWLCHLAPEIIRQLSpeteedklpFSKHSDVFAFGTIWYELHAREWPFKTQPAEAIIWQVGSGMKPNLSQIG-MGKEIS 240
                        250       260
                 ....*....|....*....|....
gi 578838380 509 DFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd14153  241 DILLFCWAYEQEERPTFSKLMEML 264
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
282-464 9.37e-13

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 69.17  E-value: 9.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATG-QEVAIKQMN----LQQQPKKELiinEILVMRENKNPN----IVNYLDSYLVGDE 352
Cdd:cd14135    1 RYRVYGYLGKGVFSNVVRARDLARGnQEVAIKIIRnnelMHKAGLKEL---EILKKLNDADPDdkkhCIRLLRHFEHKNH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 353 LWVVMEYLAGgSLTDVVTETCMDEG-QIAAV---CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCA-- 425
Cdd:cd14135   78 LCLVFESLSM-NLREVLKKYGKNVGlNIKAVrsyAQQLFLALKHLKKCNILHADIKPDNILVNEKKNTlKLCDFGSASdi 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578838380 426 ---QITPEQSKRstmvgtpYWMAPEVVTRKAYGPKVDIWSLG 464
Cdd:cd14135  157 genEITPYLVSR-------FYRAPEIILGLPYDYPIDMWSVG 191
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
285-545 1.03e-12

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 68.83  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEKIGQGASGTVYTALDIATGQE----VAIKQM-NLQQQPKKELIINEILVMRENKNPNIVNYLdSYLVGDELWVVMEY 359
Cdd:cd05111   11 KLKVLGSGVFGTVHKGIWIPEGDSikipVAIKVIqDRSGRQSFQAVTDHMLAIGSLDHAYIVRLL-GICPGASLQLVTQL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR-ST 436
Cdd:cd05111   90 LPLGSLLDHVRQHrgSLGPQLLLNWCVQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVADLLYPDDKKYfYS 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 437 MVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNgtPELQNPERLSAVFRDFLNRC 514
Cdd:cd05111  170 EAKTPIkWMALESIHFGKYTHQSDVWSYGVTVWEMMTfGAEPYAGMRLAEVPDLLEKG--ERLAQPQICTIDVYMVMVKC 247
                        250       260       270
                 ....*....|....*....|....*....|.
gi 578838380 515 LEMDVDRRGSAKELLQVLLAGGNSLHNYAII 545
Cdd:cd05111  248 WMIDENIRPTFKELANEFTRMARDPPRYLVI 278
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
285-477 1.08e-12

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 68.88  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RF-EKIGQGASGTVYTA------LDIAtgQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 356
Cdd:cd05090    8 RFmEELGECAFGKIYKGhlylpgMDHA--QLVAIKTLKDYNNPQQwNEFQQEASLMTELHHPNIVCLLGVVTQEQPVCML 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 357 MEYLAGGSL------------------TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKL 418
Cdd:cd05090   86 FEFMNQGDLheflimrsphsdvgcssdEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKI 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838380 419 TDFGFCAQITPEQSKR--STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05090  166 SDLGLSREIYSSDYYRvqNKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSfGLQPY 227
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
352-471 1.14e-12

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 68.90  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN-----------QVIHRDIKSDNILLGMDGSVKLTD 420
Cdd:cd14140   67 ELWLITAFHDKGSLTDYLKGNIVSWNELCHIAETMARGLSYLHEDvprckgeghkpAIAHRDFKSKNVLLKNDLTAVLAD 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 421 FGFCAQITPEQSKRST--MVGTPYWMAPEVV------TRKAYgPKVDIWSLGIMAIEMV 471
Cdd:cd14140  147 FGLAVRFEPGKPPGDThgQVGTRRYMAPEVLegainfQRDSF-LRIDMYAMGLVLWELV 204
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
279-510 1.20e-12

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 68.53  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTALdIATGQEVAIKQMnlqqQPKK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWV 355
Cdd:cd05072    5 PRESIKLVKKLGAGQFGEVWMGY-YNNSTKVAVKTL----KPGTmsvQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDVVTEtcmDEG------QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItp 429
Cdd:cd05072   80 ITEYMAKGSLLDFLKS---DEGgkvllpKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 430 EQSKRSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPYlnenplralyliatngtPELQNPERLSA 505
Cdd:cd05072  155 EDNEYTAREGAKFpikWTAPEAINFGSFTIKSDVWSFGILLYEIVTyGKIPY-----------------PGMSNSDVMSA 217

                 ....*
gi 578838380 506 VFRDF 510
Cdd:cd05072  218 LQRGY 222
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
285-477 1.51e-12

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 68.49  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEK-IGQGASGTVYTALDIATGQEV--AIKQMN-LQQQPKKELIINEILVM-RENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05089    5 KFEDvIGEGNFGQVIKAMIKKDGLKMnaAIKMLKeFASENDHRDFAGELEVLcKLGHHPNIINLLGACENRGYLYIAIEY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVV-----------------TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
Cdd:cd05089   85 APYGNLLDFLrksrvletdpafakehgTASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIADFG 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578838380 423 FCAqiTPEQSKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05089  165 LSR--GEEVYVKKTMGRLPVrWMAIESLNYSVYTTKSDVWSFGVLLWEIVSlGGTPY 219
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
388-540 2.34e-12

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 68.47  E-value: 2.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGI 465
Cdd:cd05103  190 KGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIykDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGV 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 466 MAIEMVE-GEPPY----LNENPLRALYLIATNGTPELQNPErlsaVFRDFLNrCLEMDVDRRGSAKELLQVLlagGNSLH 540
Cdd:cd05103  270 LLWEIFSlGASPYpgvkIDEEFCRRLKEGTRMRAPDYTTPE----MYQTMLD-CWHGEPSQRPTFSELVEHL---GNLLQ 341
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
285-532 3.19e-12

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 67.52  E-value: 3.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEK-IGQGASGTVY--TALDI---ATGQEVAIKQMNLQQQP--KKELIINEILVMRENKNPNIVNYLDS-YLVGDELWV 355
Cdd:cd05054   10 KLGKpLGRGAFGKVIqaSAFGIdksATCRTVAVKMLKEGATAseHKALMTELKILIHIGHHLNVVNLLGAcTKPGGPLMV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 356 VMEYLAGGSLTDV--------------------VTETCMDEGQIAAVCRECL-------QALDFLHSNQVIHRDIKSDNI 408
Cdd:cd05054   90 IVEFCKFGNLSNYlrskreefvpyrdkgardveEEEDDDELYKEPLTLEDLIcysfqvaRGMEFLASRKCIHRDLAARNI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 409 LLGMDGSVKLTDFGFCAQITPEQSK-RSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY----LNEN 481
Cdd:cd05054  170 LLSENNVVKICDFGLARDIYKDPDYvRKGDARLPLkWMAPESIFDKVYTTQSDVWSFGVLLWEIFSlGASPYpgvqMDEE 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578838380 482 PLRALYLIATNGTPELQNPErlsaVFRDFLNrCLEMDVDRRGSAKELLQVL 532
Cdd:cd05054  250 FCRRLKEGTRMRAPEYTTPE----IYQIMLD-CWHGEPKERPTFSELVEKL 295
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
287-482 3.30e-12

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 66.73  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVY--TALDiATGQEV--AIKQMN-LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDEL-WVVMEYL 360
Cdd:cd05058    1 EVIGKGHFGCVYhgTLID-SDGQKIhcAVKSLNrITDIEEVEQFLKEGIIMKDFSHPNVLSLLGICLPSEGSpLVVLPYM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTE-----TCMD-EGQIAAVCReclqALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ--- 431
Cdd:cd05058   80 KHGDLRNFIRSethnpTVKDlIGFGLQVAK----GMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARDIYDKEyys 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 432 SKRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLNENP 482
Cdd:cd05058  156 VHNHTGAKLPVkWMALESLQTQKFTTKSDVWSFGVLLWElMTRGAPPYPDVDS 208
PTKc_Tyro3 cd05074
Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the ...
279-532 3.97e-12

Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyro3 (or Sky) is predominantly expressed in the central nervous system and the brain, and functions as a neurotrophic factor. It is also expressed in osteoclasts and has a role in bone resorption. Tyro3 is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Tyro3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270659 [Multi-domain]  Cd Length: 284  Bit Score: 66.86  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTA---LDIATGQEVAIKQM--NLQQQPKKELIINEILVMRENKNPNIVNyldsyLVGDEL 353
Cdd:cd05074    7 QEQQFTLGRMLGKGEFGSVREAqlkSEDGSFQKVAVKMLkaDIFSSSDIEEFLREAACMKEFDHPNVIK-----LIGVSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 354 -----------WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQ-------ALDFLHSNQVIHRDIKSDNILLGMDGS 415
Cdd:cd05074   82 rsrakgrlpipMVILPFMKHGDLHTFLLMSRIGEEPFTLPLQTLVRfmidiasGMEYLSSKNFIHRDLAARNCMLNENMT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 416 VKLTDFGFCAQITPEQSKRSTMVGT-PY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLN-ENPLRALYLIAT 491
Cdd:cd05074  162 VCVADFGLSKKIYSGDYYRQGCASKlPVkWLALESLADNVYTTHSDVWAFGVTMWEiMTRGQTPYAGvENSEIYNYLIKG 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 578838380 492 NGTPelQNPERLSAVFrDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05074  242 NRLK--QPPDCLEDVY-ELMCQCWSPEPKCRPSFQHLRDQL 279
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
284-532 5.18e-12

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 66.54  E-value: 5.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 284 TRFEKIGQGASGTVYTALDIATGQE---VAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05063    8 TKQKVIGAGEFGEVFRGILKMPGRKevaVAIKTLKPGYTEKQRQdFLSEASIMGQFSHHNIIRLEGVVTKFKPAMIITEY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTETCMDEG--QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT--PEQSKRS 435
Cdd:cd05063   88 MENGALDKYLRDHDGEFSsyQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVSDFGLSRVLEddPEGTYTT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYL---NENPLRALyliatNGTPELQNPERLSAVFRDF 510
Cdd:cd05063  168 SGGKIPIrWTAPEAIAYRKFTSASDVWSFGIVMWEvMSFGERPYWdmsNHEVMKAI-----NDGFRLPAPMDCPSAVYQL 242
                        250       260
                 ....*....|....*....|..
gi 578838380 511 LNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05063  243 MLQCWQQDRARRPRFVDIVNLL 264
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
279-481 6.45e-12

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 66.25  E-value: 6.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTAlDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVME 358
Cdd:cd05070    7 PRESLQLIKRLGNGQFGEVWMG-TWNGNTKVAIKTLKPGTM-SPESFLEEAQIMKKLKHDKLVQ-LYAVVSEEPIYIVTE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRS 435
Cdd:cd05070   84 YMSKGSLLDFLKDgegRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYT 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 436 TMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPYLNEN 481
Cdd:cd05070  162 ARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILLTELVtKGRVPYPGMN 211
STKc_TTBK2 cd14129
Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2; STKs catalyze ...
282-477 6.79e-12

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. Mutations in TTBK2 is associated with the development of spinocerebellar ataxia type 11, belonging to a group of neurodegenerative disorders characterized by progressive incoordination, dysarthria and impairment of eye movements. Brain tissues of SCA11 patients show the presence of neurofibrillary tangles and tau deposition in the brain, similar to Alzheimer's disease (AD) patients. The TTBK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271031 [Multi-domain]  Cd Length: 262  Bit Score: 65.84  E-value: 6.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKqMNLQQQPKKELIInEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA 361
Cdd:cd14129    1 RWKVLRKIGGGGFGEIYDALDLLTRENVALK-VESAQQPKQVLKM-EVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETCMDEGQIAAVC---RECLQALDFLHSNQVIHRDIKSDNILLGMDGSV----KLTDFGF-------CAQI 427
Cdd:cd14129   79 GRNLADLRRSQSRGTFTISTTLrlgRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTcrkcYMLDFGLarqftnsCGDV 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578838380 428 TPEQSKrSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd14129  159 RPPRAV-AGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW 207
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
388-532 7.51e-12

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 67.34  E-value: 7.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPyWMAPEVVTRKAYGPKVDIWSLG 464
Cdd:cd05107  250 NGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPLK-WMAPESIFNNLYTTLSDVWSFG 328
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 465 IMAIEMVE-GEPPYlNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQVL 532
Cdd:cd05107  329 ILLWEIFTlGGTPY-PELPMNEQFYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQLVHLV 396
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
279-477 7.81e-12

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 65.82  E-value: 7.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTAlDIATGQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVME 358
Cdd:cd05073    9 PRESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSM-SVEAFLAEANVMKTLQHDKLVK-LHAVVTKEPIYIITE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 359 YLAGGSLTDVVTEtcmDEG------QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQS 432
Cdd:cd05073   86 FMAKGSLLDFLKS---DEGskqplpKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDN 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 433 KRSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMVE-GEPPY 477
Cdd:cd05073  161 EYTAREGAKFpikWTAPEAINFGSFTIKSDVWSFGILLMEIVTyGRIPY 209
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
288-477 8.37e-12

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 66.62  E-value: 8.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTAL--DIATGQEVAIKQmnLQQQPKKELIINEILVMRENKNPNIVNYLDSYL--VGDELWVVMEYlAGG 363
Cdd:cd07868   24 KVGRGTYGHVYKAKrkDGKDDKDYALKQ--IEGTGISMSACREIALLRELKHPNVISLQKVFLshADRKVWLLFDY-AEH 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVT----------ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD----GSVKLTDFGFC----A 425
Cdd:cd07868  101 DLWHIIKfhraskankkPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEgperGRVKIADMGFArlfnS 180
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 426 QITPeQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd07868  181 PLKP-LADLDPVVVTFWYRAPELLLgARHYTKAIDIWAIGCIFAELLTSEPIF 232
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
279-477 9.09e-12

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 66.17  E-value: 9.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYT--------------ALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPNIV 341
Cdd:cd05095    3 PRKLLTFKEKLGEGQFGEVHLceaegmekfmdkdfALEVSENQPVLVAVKMLRADANKNArndFLKEIKIMSRLKDPNII 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 342 NYLDSYLVGDELWVVMEYLAGGSLTDVV--------------------TETCMDEGQIAAvcreclqALDFLHSNQVIHR 401
Cdd:cd05095   83 RLLAVCITDDPLCMITEYMENGDLNQFLsrqqpegqlalpsnaltvsySDLRFMAAQIAS-------GMKYLSSLNFVHR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 402 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR--STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE--GEPPY 477
Cdd:cd05095  156 DLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRiqGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETLTfcREQPY 235
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
279-533 9.53e-12

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 66.15  E-value: 9.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 279 PKKKYTRFEKIGQGASGTVYTA--------LDIATGQE------VAIKQMNLQ-QQPKKELIINEILVMRENKNPNIVNY 343
Cdd:cd05097    3 PRQQLRLKEKLGEGQFGEVHLCeaeglaefLGEGAPEFdgqpvlVAVKMLRADvTKTARNDFLKEIKIMSRLKNPNIIRL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 344 LDSYLVGDELWVVMEYLAGGSLTDVVTE-----TCMDEGQIAAVCRECL--------QALDFLHSNQVIHRDIKSDNILL 410
Cdd:cd05097   83 LGVCVSDDPLCMITEYMENGDLNQFLSQreiesTFTHANNIPSVSIANLlymavqiaSGMKYLASLNFVHRDLATRNCLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 411 GMDGSVKLTDFGFCAQITPEQSKR--STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE--GEPPY--------- 477
Cdd:cd05097  163 GNHYTIKIADFGMSRNLYSGDYYRiqGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEMFTlcKEQPYsllsdeqvi 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838380 478 -----LNENPLRALYLIATNGTPelqnperlSAVFrDFLNRCLEMDVDRRGSAKELLQVLL 533
Cdd:cd05097  243 entgeFFRNQGRQIYLSQTPLCP--------SPVF-KLMMRCWSRDIKDRPTFNKIHHFLR 294
STKc_SRPK1 cd14216
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 1; STKs ...
274-480 9.81e-12

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPK1 binds with high affinity the alternative splicing factor, SRSF1 (serine/arginine-rich splicing factor 1), and regiospecifically phosphorylates 10-12 serines in its RS domain. It plays a role in the regulation of pre-mRNA splicing, chromatin structure, and germ cell development. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271118 [Multi-domain]  Cd Length: 349  Bit Score: 66.59  E-value: 9.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 274 VSVGDP-KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQpKKELIINEILVMR--ENKNPN------IVNYL 344
Cdd:cd14216    2 VKIGDLfNGRYHVIRKLGWGHFSTVWLSWDIQGKRFVAMKVVKSAEH-YTETALDEIKLLKsvRNSDPNdpnremVVQLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 345 DSYLV----GDELWVVMEYLAGGSLTDVVTET-------CmdegqIAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGM 412
Cdd:cd14216   81 DDFKIsgvnGTHICMVFEVLGHHLLKWIIKSNyqglplpC-----VKKIIRQVLQGLDYLHTKcRIIHTDIKPENILLSV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 413 DG------------------------------SVKLTDFGFCAQItpeQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS 462
Cdd:cd14216  156 NEqyirrlaaeatewqrnflvnplepknaeklKVKIADLGNACWV---HKHFTEDIQTRQYRSLEVLIGSGYNTPADIWS 232
                        250
                 ....*....|....*...
gi 578838380 463 LGIMAIEMVEGEppYLNE 480
Cdd:cd14216  233 TACMAFELATGD--YLFE 248
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
287-470 1.75e-11

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 65.16  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 287 EKIGQGASGTVYTAldIATGQEVAIKQMNLQQQPK--KELIINEILVMRENknpNIVNYL--DSYLVG--DELWVVMEYL 360
Cdd:cd14143    1 ESIGKGRFGEVWRG--RWRGEDVAVKIFSSREERSwfREAEIYQTVMLRHE---NILGFIaaDNKDNGtwTQLWLVSDYH 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQV--------IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 432
Cdd:cd14143   76 EHGSLFDYLNRYTVTVEGMIKLALSIASGLAHLHMEIVgtqgkpaiAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATD 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 433 K----RSTMVGTPYWMAPEVVTR-------KAYgPKVDIWSLGIMAIEM 470
Cdd:cd14143  156 TidiaPNHRVGTKRYMAPEVLDDtinmkhfESF-KRADIYALGLVFWEI 203
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
285-479 3.52e-11

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 63.73  E-value: 3.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 285 RFEK-IGQGASGTV-YTALDIATGQE--VAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 359
Cdd:cd05066    7 KIEKvIGAGEFGEVcSGRLKLPGKREipVAIKTLKAGYTEKQRRdFLSEASIMGQFDHPNIIHLEGVVTRSKPVMIVTEY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 360 LAGGSLTDVVTE-----TCMdegQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT--PEQS 432
Cdd:cd05066   87 MENGSLDAFLRKhdgqfTVI---QLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEddPEAA 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578838380 433 KRSTMVGTPY-WMAPEVVTRKAYGPKVDIWSLGIMAIE-MVEGEPPYLN 479
Cdd:cd05066  164 YTTRGGKIPIrWTAPEAIAYRKFTSASDVWSYGIVMWEvMSYGERPYWE 212
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
288-482 3.52e-11

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 64.29  E-value: 3.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYtaLDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENknpNIVNYLDSYLVGD----ELWVVMEYLA 361
Cdd:cd14220    2 QIGKGRYGEVW--MGKWRGEKVAVKVFFTTEEASwfRETEIYQTVLMRHE---NILGFIAADIKGTgswtQLYLITDYHE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 362 GGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN--------QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
Cdd:cd14220   77 NGSLYDFLKCTTLDTRALLKLAYSAACGLCHLHTEiygtqgkpAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNE 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838380 434 ----RSTMVGTPYWMAPEV----VTRKAYGPKV--DIWSLGIMAIEMV----------EGEPPYLNENP 482
Cdd:cd14220  157 vdvpLNTRVGTKRYMAPEVldesLNKNHFQAYImaDIYSFGLIIWEMArrcvtggiveEYQLPYYDMVP 225
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
289-497 3.93e-11

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 64.17  E-value: 3.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQ---QPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 365
Cdd:cd14026    5 LSRGAFGTVSRARHADWRVTVAIKCLKLDSpvgDSERNCLLKEAEILHKARFSYILPILGICNEPEFLGIVTEYMTNGSL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 366 TDVVTETCMdEGQIAAVCR-----ECLQALDFLH--SNQVIHRDIKSDNILLGMDGSVKLTDFGFCA--QITPEQSKRST 436
Cdd:cd14026   85 NELLHEKDI-YPDVAWPLRlrilyEIALGVNYLHnmSPPLLHHDLKTQNILLDGEFHVKIADFGLSKwrQLSISQSRSSK 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578838380 437 ---MVGTPYWMAPEvvtrkAYGP--------KVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPEL 497
Cdd:cd14026  164 sapEGGTIIYMPPE-----EYEPsqkrrasvKHDIYSYAIIMWEVLSRKIPFEEvTNPLQIMYSVSQGHRPDT 231
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
288-477 4.04e-11

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 64.32  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 288 KIGQGASGTVYTAL--DIATGQEVAIKQmnLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE--LWVVMEYlAGG 363
Cdd:cd07867    9 KVGRGTYGHVYKAKrkDGKDEKEYALKQ--IEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDrkVWLLFDY-AEH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838380 364 SLTDVVT----------ETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMD----GSVKLTDFGFC----A 425
Cdd:cd07867   86 DLWHIIKfhraskankkPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEgperGRVKIADMGFArlfnS 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578838380 426 QITPeQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPY 477
Cdd:cd07867  166 PLKP-LADLDPVVVTFWYRAPELLLgARHYTKAIDIWAIGCIFAELLTSEPIF 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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