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Conserved domains on  [gi|5822445]
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Chain B, PROTEIN (TRANSCRIPTIONAL ACTIVATOR GCN5)

Protein Classification

bromodomain-containing protein( domain architecture ID 11473733)

bromodomain-containing protein similar to Saccharomyces cerevisiae histone acetyltransferase GCN5, chromatin structure-remodeling complex subunit RSC4 and transcriptional activator SPT7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-164 3.78e-51

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 167.29  E-value: 3.78e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445    1 KIEFRVVNNDNTKE-NMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKRE-----FA 74
Cdd:COG5076  23 NELLRLVDNDSSPFpNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFEKNRpeslrFD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445   75 EIVFCAISSTEQVRGYGAHLMNHLKD--YVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLM 152
Cdd:COG5076 103 EIVFLAIESVTPESGLGSLLMAHLKTsvKKRKTPKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYY 182

                       170
                ....*....|..
gi 5822445  153 QCSMLPrIRYLD 164
Cdd:COG5076 183 EIIKSP-MDLLT 193
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-164 3.78e-51

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 167.29  E-value: 3.78e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445    1 KIEFRVVNNDNTKE-NMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKRE-----FA 74
Cdd:COG5076  23 NELLRLVDNDSSPFpNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFEKNRpeslrFD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445   75 EIVFCAISSTEQVRGYGAHLMNHLKD--YVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLM 152
Cdd:COG5076 103 EIVFLAIESVTPESGLGSLLMAHLKTsvKKRKTPKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYY 182

                       170
                ....*....|..
gi 5822445  153 QCSMLPrIRYLD 164
Cdd:COG5076 183 EIIKSP-MDLLT 193
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 58-128 1.04e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 1.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5822445     58 TVVGGITYRPFDKRE-FAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFL-TYADN-YAIGYFKKQGF 128
Cdd:pfam00583  43 ELVGFASLSIIDDEPpVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLeVAADNlAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-104 2.75e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 2.75e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 5822445   50 MAVIRKPLTVVGGITYRPFDKRE-FAEIVFCAISSTEQVRGYGAHLMNHLKDYVRN 104
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSGGdTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-164 3.78e-51

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 167.29  E-value: 3.78e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445    1 KIEFRVVNNDNTKE-NMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKRE-----FA 74
Cdd:COG5076  23 NELLRLVDNDSSPFpNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFEKNRpeslrFD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5822445   75 EIVFCAISSTEQVRGYGAHLMNHLKD--YVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLM 152
Cdd:COG5076 103 EIVFLAIESVTPESGLGSLLMAHLKTsvKKRKTPKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYY 182

                       170
                ....*....|..
gi 5822445  153 QCSMLPrIRYLD 164
Cdd:COG5076 183 EIIKSP-MDLLT 193
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 58-128 1.04e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 1.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5822445     58 TVVGGITYRPFDKRE-FAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFL-TYADN-YAIGYFKKQGF 128
Cdd:pfam00583  43 ELVGFASLSIIDDEPpVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLeVAADNlAAIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 59-129 3.59e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 43.83  E-value: 3.59e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5822445   59 VVGGITYRPFDKReFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRnTSNIKYFLTYADNYAIGYFKKQGFT 129
Cdd:COG1246  39 IVGCAALHPLDED-LAELRSLAVHPDYRGRGIGRRLLEALLAEAR-ELGLKRLFLLTTSAAIHFYEKLGFE 107
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 52-130 3.09e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 40.52  E-value: 3.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5822445     52 VIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKdYVRNTSNIKYFLTYADNYAIGYFKKQGFTK 130
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAE-AAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 61-131 3.62e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 37.71  E-value: 3.62e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5822445   61 GGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFL-TYADNY-AIGYFKKQGFTKE 131
Cdd:COG0456   1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLeVREDNEaAIALYEKLGFEEV 73
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
58-129 4.46e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 38.53  E-value: 4.46e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5822445   58 TVVGGITYRPFD---KREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNtSNIKYFLTYADNYAIGYFKKQGFT 129
Cdd:COG3153  49 EIVGHVALSPVDidgEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARE-RGARAVVLLGDPSLLPFYERFGFR 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-104 2.75e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.56  E-value: 2.75e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 5822445   50 MAVIRKPLTVVGGITYRPFDKRE-FAEIVFCAISSTEQVRGYGAHLMNHLKDYVRN 104
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSGGdTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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