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Conserved domains on  [gi|5911433|gb|AAD55791|]
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putative phosphate/phosphoenolpyruvate translocator [Rattus norvegicus]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 706146)

triose-phosphate transporter family protein belongs to the RhaT/DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT super family cl26744
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 116-231 1.64e-06

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


The actual alignment was detected with superfamily member pfam03151:

Pssm-ID: 474852 [Multi-domain]  Cd Length: 290  Bit Score: 48.05  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433    116 LLQKERLDAVTLLYATSWPSFCLLAGDALVLE------AGAAPRASHDSRLWACVLLSCFLSVVYNLASFSLLALTSALT 189
Cdd:pfam03151 168 MKGKDNLDNLNLFAIITILSLLLLLPVWLLVEgfkkfpSLLQSGKVGLKDVYMLLLLSGVCFHLYNQVAYMILERVSPVT 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 5911433    190 vHVLGNLT---VVgnLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:pfam03151 248 -HSVANTVkrvVV--IVSSILVFGNPVSPLNAIGTAIAIAGVFLY 289
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 116-231 1.64e-06

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 48.05  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433    116 LLQKERLDAVTLLYATSWPSFCLLAGDALVLE------AGAAPRASHDSRLWACVLLSCFLSVVYNLASFSLLALTSALT 189
Cdd:pfam03151 168 MKGKDNLDNLNLFAIITILSLLLLLPVWLLVEgfkkfpSLLQSGKVGLKDVYMLLLLSGVCFHLYNQVAYMILERVSPVT 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 5911433    190 vHVLGNLT---VVgnLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:pfam03151 248 -HSVANTVkrvVV--IVSSILVFGNPVSPLNAIGTAIAIAGVFLY 289
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 121-230 2.73e-05

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 44.45  E-value: 2.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433  121 RLDAVTLLYATSWPSFCLLAGDALVLEAGAAPRASHdsrLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVG 200
Cdd:COG0697 174 RLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAA---WLALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVF 250

                        90       100       110
                ....*....|....*....|....*....|
gi 5911433  201 NLILSRLLFGSHLSALSYVGIALTLSGMFL 230
Cdd:COG0697 251 AVLLGWLLLGEPLTPLQLLGAALILAGVLL 280
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 165-231 5.74e-03

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 37.41  E-value: 5.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5911433   165 LLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:PTZ00343 280 FFSGVWYYLYNEVAFYCLGKVNQVTHAVANTLKRVVIIVSSIIIFQTQVTLLGYLGMAVAILGALLY 346
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 159-231 8.92e-03

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 36.48  E-value: 8.92e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5911433  159 RLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:cd21092 162 RTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSIAGIFKEICTLLLAVHINGDHLSLLNWLGLVICLCGISLH 234
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 174-236 9.77e-03

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 36.63  E-value: 9.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5911433    174 YNLASFSLLALTSALTvHVLGNL---TVVgnLILSRLLFGSHLSALSYVGIALTLSGMFLYHNCES 236
Cdd:TIGR00817 234 YQQVAFMLLGRVSPLT-HSVGNCmkrVVV--IVVSILFFGTKISPQQVFGTGIAIAGVFLYSRVKA 296
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 116-231 1.64e-06

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 48.05  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433    116 LLQKERLDAVTLLYATSWPSFCLLAGDALVLE------AGAAPRASHDSRLWACVLLSCFLSVVYNLASFSLLALTSALT 189
Cdd:pfam03151 168 MKGKDNLDNLNLFAIITILSLLLLLPVWLLVEgfkkfpSLLQSGKVGLKDVYMLLLLSGVCFHLYNQVAYMILERVSPVT 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 5911433    190 vHVLGNLT---VVgnLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:pfam03151 248 -HSVANTVkrvVV--IVSSILVFGNPVSPLNAIGTAIAIAGVFLY 289
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 121-230 2.73e-05

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 44.45  E-value: 2.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433  121 RLDAVTLLYATSWPSFCLLAGDALVLEAGAAPRASHdsrLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVG 200
Cdd:COG0697 174 RLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAA---WLALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVF 250

                        90       100       110
                ....*....|....*....|....*....|
gi 5911433  201 NLILSRLLFGSHLSALSYVGIALTLSGMFL 230
Cdd:COG0697 251 AVLLGWLLLGEPLTPLQLLGAALILAGVLL 280
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 161-230 4.84e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 42.18  E-value: 4.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5911433    161 WACVLLSCFLS-VVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFL 230
Cdd:pfam00892  63 WLALLYLGVLGtFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 122-230 6.62e-05

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 43.29  E-value: 6.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433  122 LDAVTLLYATSWPSFCLLAgdALVLEAGAAPRASHDSRLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGN 201
Cdd:COG0697  29 LPPLQLAFLRFLLAALLLL--PLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFV 106

                        90       100
                ....*....|....*....|....*....
gi 5911433  202 LILSRLLFGSHLSALSYVGIALTLSGMFL 230
Cdd:COG0697 107 ALLAALLLGERLSRRRWLGLLLGFAGVLL 135
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 165-231 5.74e-03

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 37.41  E-value: 5.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5911433   165 LLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:PTZ00343 280 FFSGVWYYLYNEVAFYCLGKVNQVTHAVANTLKRVVIIVSSIIIFQTQVTLLGYLGMAVAILGALLY 346
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 126-231 8.11e-03

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 36.89  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911433    126 TLLYATSW--PSFCLLAGDalVLEAGAAPRASHDSRLWAcVLLSCFLSVVYNLAS-------FSLLALTSALTVHVLGNL 196
Cdd:pfam08449 192 MLFYSHLLslPFFLLLQGD--LFSAVQFCSQSPDKAVLS-LPSMLFYLLLNVLTQyvcirgvFILISEFGALTVTLVTTL 268

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 5911433    197 TVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:pfam08449 269 RKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLY 303
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 159-231 8.92e-03

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 36.48  E-value: 8.92e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5911433  159 RLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLY 231
Cdd:cd21092 162 RTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSIAGIFKEICTLLLAVHINGDHLSLLNWLGLVICLCGISLH 234
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 174-236 9.77e-03

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 36.63  E-value: 9.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5911433    174 YNLASFSLLALTSALTvHVLGNL---TVVgnLILSRLLFGSHLSALSYVGIALTLSGMFLYHNCES 236
Cdd:TIGR00817 234 YQQVAFMLLGRVSPLT-HSVGNCmkrVVV--IVVSILFFGTKISPQQVFGTGIAIAGVFLYSRVKA 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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