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Conserved domains on  [gi|595255|gb|AAA88848|]
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actin capping protein alpha subunit [Homo sapiens]

Protein Classification

F-actin-capping protein subunit alpha( domain architecture ID 10472626)

F-actin-capping protein subunit alpha binds in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-actin_cap_A pfam01267
F-actin capping protein alpha subunit;
17-282 3.99e-153

F-actin capping protein alpha subunit;


:

Pssm-ID: 460142  Cd Length: 263  Bit Score: 428.12  E-value: 3.99e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      17 AAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICF 96
Cdd:pfam01267   1 ASSFILQAPPGELNEVVNDLRALLNDDSLLQEGIAPALEQYNEEQFTPVKLPGSSHQVIISEYNKLGDGRYFDPRSKKSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      97 KFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQtIIACIESHQFQAKNFWNGRWRSE 176
Cdd:pfam01267  81 KFDHLKQEASDVEPYELESELEELRKALEKALEKYVKEHYPSGVCTVYPKTEEDGK-LAICIVANKYNPSNFWNGRWRSE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255     177 WkfTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFK 256
Cdd:pfam01267 160 Y--TVDPSSGTLTGKIKVQVHYYEDGNVQLNTSKDVSESLPVSDPSQTASDIVKAIEEAENKYQTALNESYQNLSETTFK 237

                         250       260
                  ....*....|....*....|....*.
gi 595255     257 ALRRQLPVTRTKIDWNKILSYKIGKE 282
Cdd:pfam01267 238 ALRRQLPVTRSKIDWGKIGNYRLGQD 263
 
Name Accession Description Interval E-value
F-actin_cap_A pfam01267
F-actin capping protein alpha subunit;
17-282 3.99e-153

F-actin capping protein alpha subunit;


Pssm-ID: 460142  Cd Length: 263  Bit Score: 428.12  E-value: 3.99e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      17 AAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICF 96
Cdd:pfam01267   1 ASSFILQAPPGELNEVVNDLRALLNDDSLLQEGIAPALEQYNEEQFTPVKLPGSSHQVIISEYNKLGDGRYFDPRSKKSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      97 KFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQtIIACIESHQFQAKNFWNGRWRSE 176
Cdd:pfam01267  81 KFDHLKQEASDVEPYELESELEELRKALEKALEKYVKEHYPSGVCTVYPKTEEDGK-LAICIVANKYNPSNFWNGRWRSE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255     177 WkfTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFK 256
Cdd:pfam01267 160 Y--TVDPSSGTLTGKIKVQVHYYEDGNVQLNTSKDVSESLPVSDPSQTASDIVKAIEEAENKYQTALNESYQNLSETTFK 237

                         250       260
                  ....*....|....*....|....*.
gi 595255     257 ALRRQLPVTRTKIDWNKILSYKIGKE 282
Cdd:pfam01267 238 ALRRQLPVTRSKIDWGKIGNYRLGQD 263
 
Name Accession Description Interval E-value
F-actin_cap_A pfam01267
F-actin capping protein alpha subunit;
17-282 3.99e-153

F-actin capping protein alpha subunit;


Pssm-ID: 460142  Cd Length: 263  Bit Score: 428.12  E-value: 3.99e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      17 AAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICF 96
Cdd:pfam01267   1 ASSFILQAPPGELNEVVNDLRALLNDDSLLQEGIAPALEQYNEEQFTPVKLPGSSHQVIISEYNKLGDGRYFDPRSKKSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255      97 KFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQtIIACIESHQFQAKNFWNGRWRSE 176
Cdd:pfam01267  81 KFDHLKQEASDVEPYELESELEELRKALEKALEKYVKEHYPSGVCTVYPKTEEDGK-LAICIVANKYNPSNFWNGRWRSE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595255     177 WkfTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFK 256
Cdd:pfam01267 160 Y--TVDPSSGTLTGKIKVQVHYYEDGNVQLNTSKDVSESLPVSDPSQTASDIVKAIEEAENKYQTALNESYQNLSETTFK 237

                         250       260
                  ....*....|....*....|....*.
gi 595255     257 ALRRQLPVTRTKIDWNKILSYKIGKE 282
Cdd:pfam01267 238 ALRRQLPVTRSKIDWGKIGNYRLGQD 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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